2Y9C

structure of the spliceosomal u4 snrnp core domain

• Total interactions analyzed: 276
• Total true interactions: 35
• Strongest Interaction:
  • Chains: C-F
  • Int. Res.: 76
  • Norm. En. per Res.: -3.6046
• Hub Node: L(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-40.4146	-1.1213	-111.117	-152.6529	72	26	2	6865	0	18	20
A-C	0.0	0.0	-0.032	-0.032	2	0	0	14	0	0	1
A-D	-27.3658	-44.7128	-189.365	-261.4436	93	19	10	9792	8	27	26
B-C	-41.7328	58.3424	-281.527	-264.9174	121	84	12	17074	2	45	55
B-F	0.0	0.0	-0.0097	-0.0097	5	0	0	10	0	0	2
C-F	-46.8044	-52.4557	-174.692	-273.9521	76	39	7	8098	2	11	10
D-E	0.0	0.0	-0.0005	-0.0005	2	0	0	1	0	0	0
D-G	-12.697	-10.2769	-127.319	-150.2929	69	15	1	6383	0	18	14
E-F	-8.0503	-22.5818	-126.361	-156.9931	79	16	2	7465	0	27	20
E-G	-42.3976	-22.7337	-140.73	-205.8613	88	49	11	10104	2	14	8
F-G	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
H-I	-55.1965	6.5654	-148.405	-197.0361	76	21	2	7177	0	16	24
H-K	-29.7233	-2.3144	-174.566	-206.6037	91	20	9	9367	3	23	27
H-N	0.0	0.0	-0.0017	-0.0017	2	0	0	1	0	0	0
I-J	-49.3831	21.55	-147.871	-175.7041	119	67	8	15121	3	46	53
I-M	0.0	0.0	-0.0011	-0.0011	2	0	0	3	0	0	2
J-M	-57.7878	-41.9986	-161.758	-261.5444	80	38	8	9118	1	12	10
K-L	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
K-N	-17.7654	17.6779	-137.295	-137.3824	68	6	1	6631	0	20	15
L-M	-47.504	-24.9289	-150.183	-222.6159	82	33	4	8369	2	29	21
L-N	-24.189	-19.5391	-139.661	-183.3891	74	16	9	7707	0	9	7
L-S	-4.0249	0.0	-10.1967	-14.2216	24	5	1	1213	0	0	4
L-U	0.0	-8.9362	-0.4828	-9.419	6	0	0	97	0	3	2
N-S	0.0	-18.8916	-3.1021	-21.9937	10	0	0	327	0	2	3
O-P	-37.4604	-2.9803	-79.259	-119.6997	81	38	1	7723	0	19	26
O-Q	0.0	0.0	-0.0067	-0.0067	2	0	0	7	0	0	1
O-R	-29.517	-28.2211	-158.022	-215.76	88	12	9	8412	4	25	25
P-Q	-53.0612	14.7237	-278.755	-317.0926	105	30	6	13271	2	33	44
P-T	0.0	0.0	-0.0005	-0.0005	2	0	0	1	0	0	2
Q-T	-28.5888	-66.2655	-142.884	-237.7382	72	30	7	7361	3	8	9
R-S	0.0	0.0	-0.0005	-0.0005	2	0	0	1	0	0	0
R-U	0.0	11.8414	-24.2065	-12.3651	72	16	2	6825	0	22	17
S-T	-58.133	-30.6211	-178.617	-267.371	85	34	5	9646	0	28	20
S-U	-44.4006	-18.0226	-154.675	-217.0982	80	28	8	8663	0	9	9
T-U	0.0	0.0	-0.0008	-0.0008	2	0	0	2	0	0	1

Interface residues

• A-B: ARG118A, ARG125A, ARG149A, ARG173A, ARG250B, ARG261B, ASN176A, ASN221B, ASN237B, ASN263B, ASN264B, ASP123A, ASP233B, CYS119A, GLN111A, GLN122A, GLN254B, GLU175A, GLU183A, GLU251B, GLU256B, GLY124A, GLY174A, GLY231B, GLY262B, HIS112A, HIS137A, HIS239B, ILE120A, ILE126A, ILE229B, ILE260B, ILE265B, LEU110A, LEU121A, LEU140A, LEU177A, LEU219B, LEU240B, LEU247B, LEU255B, LEU258B, LYS108A, LYS136A, LYS150A, LYS152A, LYS220B, LYS241B, LYS248B, MET109A, MET117A, MET138A, MET180A, MET245B, SER106A, SER107A, SER179A, SER211B, SER235B, SER259B, THR181A, THR223B, THR230B, THR238B, THR257B, VAL178A, VAL182A, VAL225B, VAL232B, VAL234B, VAL243B, VAL253B
• A-C: ARG347C, GLN122A
• A-D: ALA133A, ALA80D, ARG116A, ARG125A, ARG165A, ARG173A, ARG194A, ARG29D, ARG51D, ARG64D, ARG69D, ASN139A, ASN176A, ASN23D, ASN38D, ASN40D, ASN79D, ASN88D, ASN90D, ASP114A, ASP123A, ASP135A, ASP144A, ASP189A, ASP37D, ASP75D, CYS143A, CYS145A, CYS41D, GLN122A, GLN91D, GLU147A, GLU175A, GLU21D, GLY124A, GLY168A, GLY174A, GLY191A, GLY25D, GLY4D, GLY65D, HIS137A, ILE113A, ILE141A, ILE192A, ILE68D, ILE72D, ILE7D, LEU10D, LEU121A, LEU140A, LEU142A, LEU167A, LEU169A, LEU171A, LEU172A, LEU177A, LEU71D, LEU73D, LEU77D, LEU83D, LYS132A, LYS136A, LYS188A, LYS67D, LYS84D, LYS87D, MET39D, MET76D, MET82D, PHE127A, PHE131A, PHE134A, PHE70D, PRO186A, PRO187A, PRO6D, PRO74D, PRO81D, SER66D, SER85D, THR130A, THR190A, THR19D, THR22D, THR24D, TYR115A, VAL166A, VAL170A, VAL195A, VAL27D, VAL5D, VAL9D
• B-C: ALA294B, ALA296B, ALA358C, ARG205B, ARG261B, ARG266B, ARG292B, ARG319C, ARG347C, ARG355C, ARG361C, ARG394C, ARG402C, ASN221B, ASN237B, ASN263B, ASN264B, ASN338C, ASN339C, ASN348C, ASN349C, ASN364C, ASN369C, ASP272B, ASP277B, ASP282B, ASP360C, ASP404C, CYS346C, CYS363C, GLN224B, GLN341C, GLU218B, GLU284B, GLU293B, GLU314C, GLU315C, GLU368C, GLU372C, GLU376C, GLY222B, GLY262B, GLY354C, GLY403C, HIS362C, ILE217B, ILE260B, ILE265B, ILE269B, ILE396C, ILE407C, LEU203B, LEU207B, LEU210B, LEU219B, LEU270B, LEU274B, LEU276B, LEU279B, LEU316C, LEU329C, LEU332C, LEU352C, LEU367C, LEU401C, LEU414C, LYS202B, LYS220B, LYS248B, LYS286B, LYS288B, LYS290B, LYS291B, LYS318C, LYS337C, LYS350C, LYS357C, LYS371C, LYS398C, MET201B, MET208B, MET236B, MET365C, MET399C, PHE206B, PHE268B, PHE324C, PHE359C, PHE400C, PRO271B, PRO275B, PRO285B, PRO328C, SER235B, SER273B, SER289B, SER335C, SER397C, SER405C, THR216B, THR223B, THR238B, THR278B, THR333C, THR340C, TRP374C, TYR267B, TYR395C, VAL204B, VAL215B, VAL232B, VAL234B, VAL281B, VAL283B, VAL287B, VAL295B, VAL336C, VAL356C, VAL366C, VAL370C, VAL406C
• B-F: ARG266B, ARG565F, ASN567F, LYS220B, TRP525F
• C-F: ALA416C, ALA545F, ARG347C, ARG361C, ARG402C, ARG411C, ARG565F, ASN345C, ASN348C, ASN349C, ASN364C, ASN412C, ASN541F, ASN546F, ASN567F, ASN568F, ASP360C, ASP404C, ASP537F, CYS346C, CYS363C, CYS566F, GLN334C, GLN543F, GLU549F, GLU561F, GLY327C, GLY403C, GLY417C, GLY538F, GLY560F, HIS362C, HIS558F, ILE344C, ILE407C, ILE415C, ILE551F, ILE564F, LEU343C, LEU401C, LEU410C, LEU414C, LEU523F, LEU544F, LEU559F, LEU563F, LYS350C, LYS351C, LYS418C, LYS524F, MET365C, MET527F, MET540F, MET542F, PHE359C, PRO328C, PRO413C, SER330C, SER335C, SER405C, SER535F, SER556F, THR547F, TRP525F, TYR529F, TYR539F, VAL331C, VAL342C, VAL356C, VAL406C, VAL408C, VAL409C, VAL534F, VAL536F, VAL562F, VAL569F
• D-E: GLN638E, LYS67D
• D-G: ALA56D, ALA704G, ALA772G, ARG54D, ARG64D, ARG763G, ARG775G, ASN23D, ASN38D, ASN40D, ASN45D, ASN722G, ASN739G, ASN765G, ASP37D, CYS20D, CYS41D, GLN42D, GLN57D, GLN60D, GLU26D, GLU34D, GLU36D, GLU59D, GLU708G, GLU771G, GLU774G, GLY65D, GLY764G, HIS705G, HIS726G, ILE33D, ILE46D, ILE63D, ILE68D, ILE767G, ILE768G, LEU58D, LEU709G, LEU721G, LEU740G, LEU770G, LEU773G, LYS67D, LYS711G, LYS715G, LYS720G, MET43D, MET738G, MET769G, PHE712G, PHE734G, PHE737G, PRO707G, PRO736G, SER44D, SER66D, SER718G, SER751G, SER766G, THR22D, THR24D, TYR28D, TYR50D, TYR62D, VAL27D, VAL48D, VAL61D, VAL776G
• E-F: ALA661E, ARG573F, ARG623E, ARG671E, ARG676E, ASN506F, ASN541F, ASN567F, ASN568F, ASN640E, ASN655E, ASN683E, ASP552F, ASP651E, ASP682E, CYS566F, GLN626E, GLN638E, GLN673E, GLU528F, GLU576F, GLU637E, GLU652E, GLU663E, GLY526F, GLY538F, GLY553F, GLY574F, GLY649E, GLY675E, GLY681E, ILE572F, ILE643E, ILE647E, ILE648E, ILE677E, ILE684E, LEU505F, LEU511F, LEU514F, LEU523F, LEU533F, LEU570F, LEU635E, LEU656E, LEU658E, LEU674E, LEU679E, LYS508F, LYS517F, LYS522F, LYS524F, LYS672E, LYS680E, MET520F, MET540F, MET542F, MET641E, MET654E, MET678E, PHE510F, PHE622E, PHE650E, PRO504F, PRO507F, SER629E, THR685E, TRP525F, TYR539F, TYR550F, TYR571F, TYR653E, VAL519F, VAL521F, VAL536F, VAL569F, VAL575F, VAL639E, VAL657E
• E-G: ALA749G, ARG623E, ARG628E, ARG642E, ARG725G, ARG732G, ARG763G, ASN619E, ASN640E, ASN655E, ASN683E, ASN692E, ASN722G, ASN739G, ASN755G, ASN756G, ASN765G, ASP682E, ASP714G, ASP735G, ASP743G, CYS745G, GLN616E, GLN638E, GLN688E, GLN754G, GLU637E, GLU652E, GLU708G, GLU747G, GLY681E, GLY723G, GLY724G, GLY733G, GLY758G, GLY764G, HIS705G, ILE618E, ILE621E, ILE684E, ILE730G, ILE742G, ILE757G, ILE762G, ILE767G, LEU620E, LEU625E, LEU656E, LEU686E, LEU687E, LEU709G, LEU719G, LEU721G, LEU731G, LEU740G, LYS680E, LYS710G, LYS711G, MET654E, MET713G, MET738G, MET759G, PHE622E, PHE734G, PHE737G, PRO617E, PRO706G, PRO707G, PRO736G, SER666E, SER689E, SER691E, SER766G, THR668E, THR685E, TRP634E, TYR624E, TYR636E, TYR653E, VAL610E, VAL615E, VAL633E, VAL690E, VAL727G, VAL741G, VAL746G, VAL760G, VAL761G
• F-G: ASN722G, LYS524F
• H-I: ARG118H, ARG173H, ARG250I, ARG261I, ASN176H, ASN221I, ASN237I, ASN263I, ASN264I, ASP123H, ASP135H, ASP233I, CYS119H, GLN111H, GLN122H, GLN254I, GLU175H, GLU183H, GLU251I, GLU256I, GLY124H, GLY174H, GLY184H, GLY222I, GLY231I, GLY262I, HIS112H, HIS137H, HIS212I, HIS239I, ILE120H, ILE126H, ILE151H, ILE229I, ILE260I, ILE265I, LEU121H, LEU140H, LEU177H, LEU219I, LEU240I, LEU247I, LEU255I, LEU258I, LYS105H, LYS108H, LYS136H, LYS154H, LYS220I, LYS241I, MET109H, MET117H, MET138H, MET180H, MET208I, MET245I, PHE134H, PRO185H, SER106H, SER107H, SER179H, SER211I, SER235I, SER259I, THR181H, THR223I, THR230I, THR238I, THR257I, VAL178H, VAL182H, VAL225I, VAL232I, VAL234I, VAL243I, VAL253I
• H-K: ALA133H, ALA193H, ALA80K, ARG125H, ARG149H, ARG165H, ARG173H, ARG194H, ARG29K, ARG51K, ARG64K, ARG69K, ASN139H, ASN176H, ASN23K, ASN38K, ASN40K, ASN88K, ASN90K, ASP114H, ASP123H, ASP135H, ASP144H, ASP189H, ASP75K, CYS143H, CYS145H, GLN122H, GLN91K, GLU147H, GLU175H, GLU21K, GLY168H, GLY174H, GLY191H, GLY25K, GLY4K, GLY65K, GLY92K, HIS137H, ILE113H, ILE141H, ILE192H, ILE68K, ILE72K, ILE7K, LEU10K, LEU110H, LEU121H, LEU140H, LEU142H, LEU167H, LEU169H, LEU171H, LEU172H, LEU177H, LEU71K, LEU73K, LEU77K, LEU83K, LYS132H, LYS136H, LYS188H, LYS67K, LYS84K, LYS87K, MET138H, MET39K, MET76K, MET82K, MET86K, PHE127H, PHE131H, PHE134H, PHE70K, PRO6K, PRO74K, PRO81K, SER66K, SER85K, THR130H, THR190H, THR19K, THR22K, THR24K, VAL166H, VAL170H, VAL195H, VAL27K, VAL5K, VAL9K
• H-N: ASN765N, GLU175H
• I-J: ALA294I, ALA296I, ALA358J, ARG261I, ARG266I, ARG292I, ARG319J, ARG347J, ARG355J, ARG361J, ARG394J, ARG402J, ASN221I, ASN237I, ASN249I, ASN263I, ASN264I, ASN338J, ASN339J, ASN348J, ASN349J, ASN364J, ASN369J, ASP272I, ASP277I, ASP282I, ASP360J, ASP404J, CYS346J, CYS363J, GLN224I, GLN334J, GLN341J, GLU213I, GLU218I, GLU284I, GLU293I, GLU315J, GLU323J, GLU368J, GLU372J, GLY222I, GLY262I, GLY354J, GLY403J, HIS362J, ILE217I, ILE260I, ILE265I, ILE269I, ILE396J, LEU203I, LEU207I, LEU210I, LEU219I, LEU270I, LEU274I, LEU276I, LEU279I, LEU280I, LEU316J, LEU329J, LEU332J, LEU352J, LEU367J, LEU401J, LYS202I, LYS220I, LYS248I, LYS286I, LYS288I, LYS290I, LYS291I, LYS337J, LYS350J, LYS351J, LYS357J, LYS379J, LYS398J, MET236I, MET365J, MET373J, MET399J, PHE206I, PHE268I, PHE359J, PHE400J, PRO271I, PRO275I, PRO285I, PRO328J, SER235I, SER273I, SER289I, SER335J, SER397J, SER405J, THR216I, THR238I, THR278I, THR312J, THR326J, THR333J, THR340J, TRP374J, TYR267I, TYR395J, VAL204I, VAL215I, VAL232I, VAL281I, VAL283I, VAL287I, VAL295I, VAL336J, VAL356J, VAL366J, VAL370J, VAL406J
• I-M: LYS220I, TRP525M
• J-M: ALA416J, ALA545M, ARG347J, ARG361J, ARG402J, ARG411J, ARG565M, ASN338J, ASN345J, ASN348J, ASN349J, ASN364J, ASN412J, ASN541M, ASN546M, ASN567M, ASN568M, ASP360J, ASP404J, ASP537M, CYS346J, CYS363J, CYS566M, GLN334J, GLN543M, GLU548M, GLU549M, GLU561M, GLY327J, GLY403J, GLY417J, GLY526M, GLY538M, GLY557M, GLY560M, HIS362J, HIS558M, ILE344J, ILE407J, ILE415J, ILE551M, ILE564M, LEU329J, LEU332J, LEU343J, LEU410J, LEU414J, LEU523M, LEU544M, LEU559M, LEU563M, LYS350J, LYS351J, LYS418J, LYS524M, MET365J, MET527M, MET540M, MET542M, PHE359J, PRO328J, PRO413J, SER330J, SER335J, SER405J, SER535M, THR333J, THR547M, TRP525M, TYR529M, TYR539M, VAL331J, VAL342J, VAL406J, VAL408J, VAL409J, VAL534M, VAL536M, VAL562M, VAL569M
• K-L: GLN638L, LYS67K
• K-N: ALA35K, ALA704N, ALA772N, ARG51K, ARG54K, ARG64K, ARG763N, ASN23K, ASN38K, ASN40K, ASN722N, ASN739N, ASN765N, ASP37K, ASP52K, CYS41K, GLN42K, GLN57K, GLN60K, GLU26K, GLU34K, GLU36K, GLU59K, GLU708N, GLU771N, GLY65K, GLY724N, GLY764N, HIS705N, HIS726N, ILE33K, ILE46K, ILE63K, ILE68K, ILE767N, ILE768N, LEU58K, LEU709N, LEU717N, LEU721N, LEU740N, LEU770N, LYS67K, LYS711N, LYS715N, LYS720N, MET39K, MET43K, MET738N, MET769N, PHE712N, PHE734N, PHE737N, PRO706N, PRO707N, PRO736N, SER66K, SER718N, SER751N, SER766N, THR22K, THR24K, TYR28K, TYR50K, TYR62K, VAL27K, VAL48K, VAL61K
• L-M: ALA554M, ALA661L, ARG565M, ARG573M, ARG671L, ARG676L, ASN506M, ASN541M, ASN567M, ASN568M, ASN640L, ASN655L, ASN683L, ASP537M, ASP552M, ASP651L, ASP659L, ASP682L, CYS566M, GLN626L, GLN638L, GLN673L, GLU528M, GLU576M, GLU637L, GLU652L, GLU663L, GLY526M, GLY538M, GLY553M, GLY574M, GLY649L, GLY675L, GLY681L, ILE551M, ILE572M, ILE643L, ILE648L, ILE677L, ILE684L, LEU505M, LEU511M, LEU514M, LEU523M, LEU533M, LEU570M, LEU635L, LEU656L, LEU658L, LEU674L, LEU679L, LYS508M, LYS517M, LYS522M, LYS524M, LYS672L, LYS680L, MET520M, MET540M, MET542M, MET641L, MET654L, MET678L, PHE510M, PHE622L, PHE650L, PRO504M, PRO507M, PRO509M, THR685L, TRP525M, TYR539M, TYR550M, TYR571M, TYR653L, VAL519M, VAL521M, VAL536M, VAL569M, VAL575M, VAL639L, VAL657L
• L-N: ARG623L, ARG628L, ARG642L, ARG725N, ARG732N, ARG763N, ASN619L, ASN640L, ASN655L, ASN683L, ASN692L, ASN722N, ASN739N, ASN755N, ASN756N, ASN765N, ASP682L, ASP714N, ASP735N, CYS745N, GLN638L, GLN688L, GLU637L, GLU652L, GLU747N, GLY681L, GLY723N, GLY733N, GLY758N, GLY764N, HIS705N, ILE618L, ILE621L, ILE684L, ILE742N, ILE757N, ILE762N, ILE767N, LEU620L, LEU625L, LEU656L, LEU686L, LEU687L, LEU709N, LEU719N, LEU721N, LEU731N, LEU740N, LYS680L, LYS710N, MET654L, MET713N, MET738N, MET759N, PHE622L, PHE734N, PHE737N, PRO706N, PRO736N, SER666L, SER689L, SER691L, SER766N, THR685L, TRP634L, TYR624L, TYR636L, TYR653L, VAL633L, VAL690L, VAL727N, VAL741N, VAL760N, VAL761N
• L-S: ARG628L, ARG628S, ARG630L, ARG630S, ASN627L, ASN627S, ASN692L, ASP660S, CYS646S, GLN626L, GLN626S, GLN632L, GLN632S, GLY645S, ILE631L, ILE631S, SER629L, SER629S, SER689L, SER691L, VAL615S, VAL633S, VAL690L, VAL690S
• L-U: ARG630L, ASP743U, GLU744U, GLY758U, ILE631L, MET759U
• N-S: ARG630S, ASN756N, ASP743N, GLU744N, GLY758N, ILE631S, ILE648S, ILE757N, MET759N, SER629S
• O-P: ARG118O, ARG173O, ARG205P, ARG250P, ARG261P, ASN176O, ASN221P, ASN237P, ASN263P, ASN264P, ASP123O, ASP135O, ASP233P, CYS119O, GLN111O, GLN122O, GLN254P, GLU175O, GLU183O, GLU251P, GLU256P, GLY124O, GLY174O, GLY184O, GLY231P, GLY262P, HIS112O, HIS137O, HIS239P, ILE120O, ILE126O, ILE217P, ILE229P, ILE260P, ILE265P, LEU110O, LEU121O, LEU140O, LEU177O, LEU219P, LEU240P, LEU247P, LEU255P, LEU258P, LYS105O, LYS108O, LYS136O, LYS150O, LYS152O, LYS220P, LYS241P, MET109O, MET117O, MET138O, MET180O, MET208P, MET236P, MET245P, PHE131O, PHE134O, PRO185O, SER106O, SER107O, SER179O, SER211P, SER235P, SER259P, THR181O, THR223P, THR230P, THR238P, THR257P, TYR115O, VAL178O, VAL182O, VAL204P, VAL225P, VAL232P, VAL234P, VAL243P, VAL253P
• O-Q: ARG347Q, GLN122O
• O-R: ALA133O, ALA193O, ALA80R, ARG125O, ARG165O, ARG173O, ARG194O, ARG64R, ARG69R, ASN139O, ASN176O, ASN23R, ASN38R, ASN40R, ASN79R, ASN88R, ASN90R, ASP114O, ASP123O, ASP135O, ASP144O, ASP75R, CYS143O, CYS145O, CYS20R, GLN122O, GLN91R, GLU147O, GLU175O, GLU21R, GLY168O, GLY174O, GLY191O, GLY25R, GLY65R, GLY92R, HIS137O, ILE113O, ILE141O, ILE192O, ILE68R, ILE72R, ILE7R, LEU10R, LEU110O, LEU121O, LEU140O, LEU142O, LEU167O, LEU169O, LEU171O, LEU172O, LEU71R, LEU73R, LEU77R, LEU83R, LYS132O, LYS136O, LYS188O, LYS67R, LYS84R, LYS87R, LYS89R, MET39R, MET76R, PHE127O, PHE131O, PHE134O, PHE70R, PRO186O, PRO6R, PRO74R, PRO81R, SER66R, SER85R, THR130O, THR19R, THR22R, THR24R, THR49R, TYR115O, TYR28R, VAL166O, VAL170O, VAL195O, VAL27R, VAL5R, VAL9R
• P-Q: ALA294P, ALA358Q, ARG205P, ARG261P, ARG266P, ARG292P, ARG347Q, ARG355Q, ARG361Q, ARG394Q, ARG402Q, ASN221P, ASN237P, ASN249P, ASN263P, ASN264P, ASN338Q, ASN339Q, ASN348Q, ASN349Q, ASN364Q, ASN369Q, ASP272P, ASP277P, ASP282P, ASP360Q, ASP404Q, CYS346Q, CYS363Q, GLN224P, GLN341Q, GLU218P, GLU284P, GLU293P, GLU368Q, GLU372Q, GLY222P, GLY262P, GLY354Q, GLY403Q, HIS362Q, ILE217P, ILE260P, ILE265P, ILE269P, ILE396Q, LEU203P, LEU207P, LEU210P, LEU219P, LEU270P, LEU274P, LEU276P, LEU279P, LEU280P, LEU352Q, LEU367Q, LEU401Q, LEU414Q, LYS202P, LYS220P, LYS248P, LYS286P, LYS288P, LYS290P, LYS291P, LYS337Q, LYS350Q, LYS357Q, LYS398Q, MET236P, MET365Q, MET399Q, PHE206P, PHE268P, PHE359Q, PHE400Q, PRO271P, PRO275P, PRO285P, SER235P, SER273P, SER289P, SER335Q, SER397Q, SER405Q, THR216P, THR238P, THR333Q, THR340Q, THR375Q, TRP374Q, TYR267P, TYR395Q, VAL204P, VAL215P, VAL283P, VAL287P, VAL295P, VAL336Q, VAL356Q, VAL366Q, VAL370Q, VAL377Q, VAL406Q
• P-T: ARG266P, TRP525T
• Q-T: ALA545T, ARG347Q, ARG361Q, ARG402Q, ARG411Q, ARG565T, ASN345Q, ASN348Q, ASN349Q, ASN364Q, ASN412Q, ASN541T, ASN546T, ASN567T, ASN568T, ASP360Q, ASP404Q, ASP537T, CYS346Q, CYS363Q, CYS566T, GLN334Q, GLN543T, GLU549T, GLU561T, GLY327Q, GLY403Q, GLY538T, GLY557T, GLY560T, HIS362Q, HIS558T, ILE344Q, ILE407Q, ILE551T, ILE564T, LEU332Q, LEU343Q, LEU410Q, LEU414Q, LEU523T, LEU544T, LEU559T, LEU563T, LYS350Q, LYS351Q, LYS524T, MET365Q, MET527T, MET540T, PRO328Q, PRO413Q, SER330Q, SER335Q, SER405Q, SER535T, SER556T, THR326Q, THR375Q, THR547T, TRP525T, TYR529T, TYR539T, VAL331Q, VAL342Q, VAL406Q, VAL408Q, VAL409Q, VAL534T, VAL536T, VAL562T, VAL569T
• R-S: GLN638S, LYS67R
• R-U: ALA56R, ALA704U, ALA772U, ARG51R, ARG54R, ARG64R, ARG763U, ARG775U, ASN23R, ASN38R, ASN40R, ASN722U, ASN739U, ASN765U, ASP37R, ASP735U, CYS20R, CYS41R, GLN42R, GLN57R, GLN60R, GLU21R, GLU26R, GLU34R, GLU36R, GLU59R, GLU708U, GLU771U, GLU774U, GLY65R, GLY724U, GLY764U, HIS705U, HIS726U, ILE33R, ILE46R, ILE63R, ILE767U, ILE768U, LEU58R, LEU709U, LEU717U, LEU719U, LEU721U, LEU740U, LEU770U, LEU773U, LYS67R, LYS711U, LYS715U, LYS720U, MET43R, MET738U, MET769U, PHE712U, PHE734U, PHE737U, PRO707U, PRO736U, SER66R, SER718U, SER751U, SER766U, THR22R, THR24R, TYR28R, TYR50R, TYR62R, VAL27R, VAL48R, VAL61R, VAL776U
• S-T: ALA661S, ARG565T, ARG573T, ARG623S, ARG671S, ARG676S, ASN506T, ASN512T, ASN541T, ASN567T, ASN568T, ASN640S, ASN655S, ASN683S, ASP552T, ASP651S, ASP659S, ASP682S, CYS566T, GLN626S, GLN638S, GLN673S, GLU528T, GLU576T, GLU577T, GLU637S, GLU652S, GLU663S, GLY526T, GLY538T, GLY553T, GLY574T, GLY649S, GLY675S, GLY681S, ILE572T, ILE643S, ILE647S, ILE648S, ILE677S, ILE684S, LEU505T, LEU511T, LEU514T, LEU523T, LEU533T, LEU570T, LEU625S, LEU635S, LEU656S, LEU658S, LEU674S, LEU679S, LYS508T, LYS517T, LYS522T, LYS524T, LYS672S, LYS680S, MET520T, MET540T, MET542T, MET641S, MET654S, MET678S, PHE510T, PHE622S, PHE650S, PRO504T, PRO507T, PRO509T, SER629S, THR515T, THR685S, TRP525T, TYR539T, TYR571T, TYR653S, VAL519T, VAL521T, VAL536T, VAL569T, VAL575T, VAL639S, VAL657S
• S-U: ALA704U, ALA749U, ARG628S, ARG642S, ARG725U, ARG732U, ARG763U, ASN619S, ASN640S, ASN655S, ASN683S, ASN692S, ASN722U, ASN739U, ASN755U, ASN756U, ASN765U, ASP682S, ASP714U, ASP735U, CYS745U, GLN616S, GLN638S, GLN688S, GLN754U, GLU637S, GLU652S, GLU708U, GLU747U, GLY681S, GLY723U, GLY733U, GLY758U, GLY764U, HIS705U, ILE618S, ILE621S, ILE684S, ILE742U, ILE757U, ILE762U, ILE767U, LEU620S, LEU625S, LEU656S, LEU686S, LEU687S, LEU709U, LEU719U, LEU721U, LEU731U, LEU740U, LYS680S, LYS710U, MET654S, MET713U, MET759U, PHE622S, PHE734U, PHE737U, PRO617S, PRO706U, PRO707U, PRO736U, SER666S, SER689S, SER691S, SER766U, THR668S, THR685S, TRP634S, TYR624S, TYR636S, TYR653S, VAL633S, VAL690S, VAL727U, VAL741U, VAL760U, VAL761U
• T-U: ASN722U, LYS524T