2Y94

structure of an active form of mammalian ampk

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: B-E
  • Int. Res.: 104
  • Norm. En. per Res.: -4.6214
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-10.1467	-31.6526	-158.507	-200.3063	65	8	9	7362	0	15	12
A-B	-54.4797	-62.3743	-513.045	-629.899	160	29	13	19524	3	56	55
A-E	-10.5676	-13.0393	-169.258	-192.8648	115	10	1	7129	2	47	57
C-B	0.0	-5.9027	-115.596	-121.4987	41	3	7	4962	1	5	6
C-E	-43.7138	-15.8408	-132.616	-192.1706	53	12	4	5265	1	10	7
B-E	-137.3384	-14.3207	-328.966	-480.6251	104	21	14	12927	0	18	19

Interface residues

• A-C: ALA411A, ALA416A, ALA540C, ALA547C, ARG415A, ARG435A, ARG436A, ARG464A, ARG527C, ASN438A, ASN541C, ASP462A, ASP467A, ASP468A, CYS414A, CYS539C, GLN419A, GLN548C, GLU412A, GLU534C, GLU537C, GLY399A, GLY529C, HIS397A, HIS531C, ILE400A, ILE409A, ILE417A, ILE466A, ILE533C, ILE543C, ILE545C, LEU420A, LEU432A, LEU449A, LEU461A, LEU542C, LEU546C, LYS418A, LYS437A, LYS446A, LYS544C, MET410A, MET447A, MET538C, PHE444A, PHE463A, PHE535C, PHE536C, PRO439A, PRO528C, SER402A, SER404A, SER442A, SER445A, SER448A, SER465A, SER530C, THR441A, THR443A, THR532C, TYR422A, VAL413A, VAL434A, VAL440A
• A-B: ALA191A, ALA228B, ALA243B, ALA255B, ALA374A, ALA394A, ARG132A, ARG171A, ARG188A, ARG201B, ARG256A, ARG258B, ARG358A, ARG373A, ARG375A, ARG401A, ARG405A, ARG436A, ARG464A, ASN218B, ASN222B, ASN234B, ASN239B, ASN407A, ASN428A, ASP166A, ASP220B, ASP226B, ASP252A, ASP289A, ASP290A, ASP352A, ASP353A, ASP455A, ASP462A, ASP467A, CYS225B, GLN214B, GLN450A, GLN453A, GLU168A, GLU183A, GLU194A, GLU232B, GLU380A, GLU469A, GLY167A, GLY187A, GLY192A, GLY399A, HIS131A, HIS133A, HIS211B, HIS235B, HIS240B, HIS257B, HIS354A, HIS355A, HIS360A, HIS376A, HIS397A, ILE185A, ILE207B, ILE216B, ILE223B, ILE246B, ILE400A, ILE409A, ILE466A, LEU170A, LEU189A, LEU208B, LEU212B, LEU213B, LEU217B, LEU229B, LEU230B, LEU238B, LEU241B, LEU244B, LEU253B, LEU267B, LEU268B, LEU293A, LEU351A, LEU356A, LEU378A, LEU381A, LEU398A, LEU449A, LEU451A, LEU460A, LEU461A, LYS203B, LYS219B, LYS247B, LYS255A, LYS260A, LYS260B, LYS261B, LYS262B, LYS270B, LYS385A, LYS393A, LYS395A, MET134A, MET164A, MET237B, MET251B, MET254A, MET287A, MET410A, MET447A, PHE169A, PHE202B, PHE463A, PRO193A, PRO205B, PRO206B, PRO209B, PRO210B, PRO227B, PRO231B, PRO233B, PRO253A, PRO346A, PRO359A, PRO372A, PRO406A, PRO429A, SER165A, SER186A, SER204B, SER224B, SER245B, SER254B, SER448A, SER465A, THR221B, THR256B, THR258A, THR266B, THR286A, THR357A, TRP396A, TYR190A, TYR242B, TYR263B, TYR269B, TYR430A, TYR431A, TYR452A, TYR459A, VAL136A, VAL195A, VAL215B, VAL236B, VAL252B, VAL391A, VAL454A
• A-E: ALA249E, ALA250E, ALA264E, ALA294E, ALA343A, ALA374A, ALA394A, ALA70E, ARG151E, ARG170E, ARG268E, ARG36E, ARG373A, ARG375A, ARG436A, ARG69E, ASN134E, ASN161E, ASN247E, ASN382A, ASN438A, ASN66E, ASP244E, ASP290A, ASP339A, ASP348A, ASP352A, ASP353A, ASP379A, ASP39E, ASP467A, ASP75E, GLN266E, GLN384A, GLN79E, GLU158E, GLU251E, GLU273E, GLU295A, GLU295E, GLU380A, GLY67E, HIS267E, HIS270E, HIS297E, HIS354A, HIS355A, HIS35E, HIS376A, ILE179E, ILE246E, ILE41E, ILE87E, LEU177E, LEU248E, LEU265E, LEU293A, LEU342A, LEU351A, LEU356A, LEU378A, LEU381A, LEU40E, LEU63E, LYS169E, LYS173E, LYS252E, LYS294A, LYS338A, LYS393A, LYS46E, LYS77E, LYS78E, PHE174E, PHE178E, PHE243E, PHE272E, PHE31E, PHE350A, PRO346A, PRO347A, PRO383A, PRO42E, PRO439A, SER159E, SER269E, SER345A, SER349A, SER386A, SER442A, SER44E, SER45E, SER76E, SER80E, THR167E, THR180E, THR253E, THR344A, THR371A, THR43E, THR441A, THR443A, THR65E, TRP396A, TRP74E, TYR164E, TYR240E, TYR271E, TYR341A, VAL245E, VAL296E, VAL440A, VAL48E, VAL64E, VAL68E
• C-B: ALA243B, ALA255B, ALA540C, ALA547C, ASN239B, ASN541C, CYS539C, GLN548C, GLU534C, GLU537C, HIS240B, HIS257B, HIS531C, ILE246B, ILE272B, ILE533C, ILE543C, ILE545C, LEU241B, LEU253B, LEU267B, LEU268B, LEU542C, LEU546C, LYS270B, LYS544C, MET251B, MET538C, PHE535C, PHE536C, PRO271B, SER254B, SER530C, THR256B, THR265B, THR266B, THR532C, TYR242B, TYR269B, VAL252B, VAL264B
• C-E: ALA135E, ALA525C, ARG146E, ARG527C, ASN147E, ASN161E, ASN541C, ASP156E, ASP51E, ASP75E, CYS130E, GLN79E, GLU158E, GLU534C, GLU537C, GLY160E, GLY529C, GLY83E, HIS531C, ILE131E, ILE155E, ILE533C, LEU128E, LEU152E, LEU163E, LEU47E, LEU73E, LYS77E, LYS78E, PHE50E, PHE535C, PHE536C, PHE81E, PRO127E, PRO153E, PRO157E, PRO526C, PRO528C, PRO72E, SER132E, SER143E, SER159E, SER530C, SER76E, SER80E, THR162E, THR532C, TRP74E, VAL129E, VAL48E, VAL49E, VAL524C, VAL82E
• B-E: ALA228B, ALA255B, ALA59E, ALA62E, ALA70E, ALA71E, ARG170E, ARG258B, ARG36E, ARG69E, ASN134E, ASN161E, ASN66E, ASP156E, ASP220B, ASP226B, ASP248B, ASP39E, ASP51E, CYS225B, CYS37E, GLN55E, GLN79E, GLU114E, GLU158E, GLU232B, GLU295E, GLY67E, HIS257B, ILE113E, ILE155E, ILE165E, ILE216B, ILE272B, ILE41E, LEU163E, LEU217B, LEU229B, LEU230B, LEU244B, LEU253B, LEU267B, LEU268B, LEU40E, LEU47E, LEU54E, LEU63E, LEU73E, LYS112E, LYS169E, LYS173E, LYS219B, LYS247B, LYS252E, LYS260B, LYS261B, LYS262B, LYS270B, LYS46E, LYS58E, MET251B, PHE174E, PHE243E, PHE50E, PHE61E, PHE81E, PRO133E, PRO157E, PRO227B, PRO231B, PRO233B, PRO271B, PRO42E, PRO72E, SER132E, SER159E, SER224B, SER249B, SER254B, SER44E, SER45E, SER53E, SER76E, THR162E, THR221B, THR256B, THR265B, THR266B, THR43E, THR52E, THR65E, TRP74E, TYR164E, TYR259B, TYR263B, TYR269B, TYR38E, VAL154E, VAL250B, VAL252B, VAL264B, VAL48E, VAL49E, VAL68E