2Y6E

ubiquitin specific protease 4 is inhibited by its ubiquitin- like domain

• Total interactions analyzed: 15
• Total true interactions: 12
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 43
  • Norm. En. per Res.: -2.8036
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-11.3321	-11.529	-96.7743	-119.6353	66	11	4	4511	0	11	13
A-C	0.0	2.3281	-122.732	-120.4039	56	1	1	4283	2	16	22
A-E	0.0	27.9859	-51.049	-23.0631	39	3	0	2170	1	19	25
A-F	0.0	0.0166	-91.6496	-91.633	37	1	1	3245	1	12	15
B-C	0.0	29.1531	-53.901	-24.7479	41	6	0	2258	1	21	29
B-D	-11.7558	-22.7052	-86.0941	-120.5552	43	1	1	3415	1	13	19
B-E	-3.3031	0.8139	-91.5693	-94.0585	39	0	1	3400	1	14	14
C-D	-12.1412	-10.7176	-96.2858	-119.1446	64	1	4	3923	0	10	12
C-F	0.0	-0.0798	-89.8225	-89.9023	42	2	1	3261	1	12	15
D-E	0.0	-2.533	-86.7627	-89.2957	38	0	1	3141	1	12	14
D-F	0.0	52.7655	-52.7018	0.0637	42	2	0	2088	0	25	31
E-F	-32.011	-10.937	-110.706	-153.654	70	7	3	5025	0	10	9

Interface residues

• A-B: ALA368B, ALA371A, ALA371B, ALA876A, ALA876B, ALA914A, ARG373A, ARG373B, ASN306A, ASN306B, ASN309A, ASN309B, ASN314B, ASN901A, ASN901B, ASP367B, ASP839A, ASP898A, ASP898B, ASP899A, ASP899B, CYS302B, GLN390A, GLN390B, GLN391A, GLN391B, GLY303B, GLY305A, GLY305B, GLY308A, GLY308B, GLY388A, GLY388B, GLY875A, GLY875B, GLY878A, GLY878B, GLY880A, GLY880B, HIS369A, HIS369B, HIS873A, HIS881A, HIS881B, LEU304B, LEU307A, LEU307B, LYS376A, LYS376B, LYS913A, LYS913B, MET877A, MET877B, PRO372B, SER900A, SER900B, THR310A, THR310B, TYR389A, TYR389B, TYR874A, TYR874B, VAL370B, VAL879A, VAL879B, VAL902B
• A-C: ALA383C, ALA876A, ARG341C, ARG381C, ARG442C, ARG832A, ARG835A, ASN340C, ASN343C, ASN801C, ASN831A, ASP342C, ASP403C, ASP408C, ASP836A, CYS799C, CYS802A, GLN385C, GLN391A, GLN807A, GLU350C, GLU407C, GLU793A, GLY346C, GLY349C, GLY404C, GLY792A, GLY878A, ILE351C, LEU345C, LEU401C, LEU791A, LYS348C, LYS415C, LYS803A, LYS803C, LYS804A, LYS837A, MET347C, MET877A, PHE382C, PHE386C, PHE400C, PRO344C, PRO384C, PRO416C, PRO796A, PRO800C, SER829A, THR790A, TRP834A, TYR417C, TYR798A, TYR830A, TYR833A, VAL379C
• A-E: ALA354E, ALA371A, ALA371E, ARG341A, ARG341E, ARG366A, ARG366E, ARG373A, ARG373E, ARG381A, ARG381E, ASP367A, ASP367E, GLN361A, GLN361E, GLN378A, GLN378E, GLU336A, GLU336E, GLU350A, GLU350E, GLU357A, GLU357E, LEU307A, LEU307E, LYS348A, LYS348E, LYS376A, LYS376E, MET374A, MET374E, PHE375A, PHE375E, PHE382A, PHE382E, PRO372A, PRO372E, THR377A, THR377E
• A-F: ALA383A, ALA399A, ALA876F, ARG341A, ARG381A, ARG832F, ARG835F, ASN340A, ASN343A, ASN831F, ASP342A, ASP403A, ASP408A, ASP836F, GLN385A, GLN391F, GLU350A, GLU407A, GLY346A, GLY349A, GLY404A, GLY878F, ILE351A, LEU345A, LYS348A, MET347A, MET877F, PHE382A, PHE386A, PHE400A, PRO344A, PRO384A, SER829F, TRP834F, TYR830F, TYR833F, VAL379A
• B-C: ALA354B, ALA371B, ALA371C, ARG341B, ARG341C, ARG366B, ARG366C, ARG373B, ARG373C, ARG381B, ARG381C, ASP367B, ASP367C, GLN361B, GLN361C, GLN378B, GLN378C, GLU336B, GLU336C, GLU350B, GLU350C, GLU353B, GLU353C, GLU357B, GLU357C, LEU307B, LEU307C, LYS348B, LYS348C, LYS376B, LYS376C, MET374B, MET374C, PHE375B, PHE375C, PHE382B, PHE382C, PRO372B, PRO372C, THR377B, THR377C
• B-D: ALA383B, ALA399B, ALA876D, ARG341B, ARG381B, ARG832D, ARG835D, ASN340B, ASN343B, ASN831D, ASP342B, ASP403B, ASP408B, ASP836D, GLN385B, GLN391D, GLU350B, GLU407B, GLY346B, GLY349B, GLY404B, GLY878D, HIS805B, HIS805D, ILE351B, LEU345B, LEU401B, LYS348B, LYS803B, LYS804D, MET347B, MET877D, PHE382B, PHE386B, PHE400B, PRO344B, PRO384B, SER829D, TRP834D, TYR830D, TYR833D, VAL379B, VAL879D
• B-E: ALA383E, ALA399E, ALA876B, ARG341E, ARG381E, ARG832B, ARG835B, ASN340E, ASN343E, ASN831B, ASP342E, ASP403E, ASP408E, ASP836B, GLN385E, GLN391B, GLU350E, GLU407E, GLY346E, GLY349E, GLY404E, GLY878B, ILE351E, LEU345E, LYS348E, LYS837B, MET347E, MET877B, PHE382E, PHE386E, PHE400E, PRO344E, PRO384E, SER829B, TRP834B, TYR830B, TYR833B, VAL379E, VAL879B
• C-D: ALA368D, ALA371C, ALA371D, ALA876C, ALA876D, ALA914C, ARG373C, ARG373D, ASN306C, ASN306D, ASN309C, ASN309D, ASN314D, ASN901C, ASN901D, ASP367D, ASP839C, ASP898C, ASP898D, ASP899C, ASP899D, GLN390C, GLN390D, GLN391C, GLY303D, GLY305C, GLY305D, GLY308C, GLY308D, GLY388C, GLY388D, GLY875C, GLY875D, GLY878C, GLY878D, GLY880C, GLY880D, HIS369C, HIS369D, HIS873C, HIS881C, HIS881D, LEU304D, LEU307C, LEU307D, LYS376C, LYS376D, LYS913C, LYS913D, MET877C, MET877D, PRO372D, SER900C, SER900D, THR310C, THR310D, TRP834C, TYR389C, TYR389D, TYR874C, TYR874D, VAL370D, VAL879C, VAL879D
• C-F: ALA383F, ALA399F, ALA876C, ARG341F, ARG381F, ARG832C, ARG835C, ASN340F, ASN343F, ASN831C, ASP342F, ASP403F, ASP408F, ASP836C, GLN385F, GLN391C, GLN807C, GLU350F, GLU407F, GLY346F, GLY349F, GLY404F, GLY878C, ILE351F, LEU345F, LEU420F, LEU483C, LYS348F, LYS414F, LYS837C, MET347F, MET877C, PHE382F, PHE386F, PHE400F, PRO344F, PRO384F, SER829C, TRP834C, TYR830C, TYR833C, VAL379F
• D-E: ALA383D, ALA399D, ALA876E, ARG341D, ARG381D, ARG832E, ARG835E, ASN340D, ASN343D, ASN831E, ASP342D, ASP403D, ASP408D, ASP836E, GLN385D, GLN391E, GLU350D, GLU407D, GLY346D, GLY349D, GLY404D, GLY878E, ILE351D, LEU345D, LYS348D, LYS837E, MET347D, MET877E, PHE382D, PHE386D, PHE400D, PRO344D, PRO384D, SER829E, TRP834E, TYR830E, TYR833E, VAL379D
• D-F: ALA371D, ALA371F, ARG341D, ARG341F, ARG366D, ARG366F, ARG373D, ARG373F, ARG381D, ARG381F, ASP367D, ASP367F, GLN361D, GLN361F, GLN378D, GLN378F, GLU336D, GLU336F, GLU350D, GLU350F, GLU353D, GLU353F, GLU357D, GLU357F, HIS369D, ILE339F, LEU307D, LEU307F, LYS348D, LYS348F, LYS376D, LYS376F, MET374D, MET374F, PHE375D, PHE375F, PHE382D, PHE382F, PRO372D, PRO372F, THR377D, THR377F
• E-F: ALA368E, ALA368F, ALA371E, ALA371F, ALA876E, ALA876F, ALA914E, ARG373E, ARG373F, ASN306E, ASN306F, ASN309E, ASN309F, ASN314E, ASN314F, ASN901E, ASN901F, ASP839E, ASP898E, ASP898F, ASP899E, ASP899F, GLN390E, GLN390F, GLN391E, GLN391F, GLN392F, GLY303E, GLY303F, GLY305E, GLY305F, GLY308E, GLY308F, GLY388E, GLY388F, GLY875E, GLY875F, GLY878E, GLY878F, GLY880E, GLY880F, HIS369E, HIS369F, HIS881E, HIS881F, LEU304E, LEU304F, LEU307E, LEU307F, LYS376E, LYS376F, LYS913E, LYS913F, MET877E, MET877F, PRO372E, PRO372F, SER900E, SER900F, THR310E, THR310F, TRP834E, TYR389E, TYR389F, TYR874E, TYR874F, VAL370E, VAL370F, VAL879E, VAL879F