2Y5L

orally active aminopyridines as inhibitors of tetrameric fructose 1,6-bisphosphatase

• Total interactions analyzed: 28
• Total true interactions: 14
• Strongest Interaction:
  • Chains: E-G
  • Int. Res.: 126
  • Norm. En. per Res.: -3.7634
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-128.5074	28.2214	-702.705	-802.9911	222	25	28	27622	2	50	30
A-C	-61.8863	-92.7567	-275.985	-430.628	127	12	4	10831	5	25	29
A-D	-15.0784	0.4327	-98.6537	-113.2994	67	2	11	4139	0	2	8
B-C	-19.6517	0.0	-104.942	-124.5937	67	5	11	4167	0	2	7
B-D	-90.7658	-102.8357	-269.151	-462.7525	129	30	4	11236	6	25	28
B-E	0.0	-8.5595	-5.275	-13.8345	16	0	0	425	0	14	9
B-F	0.0	1.4525	-8.438	-6.9854	16	0	0	533	0	9	10
C-D	-96.8192	30.831	-681.556	-747.5442	214	25	28	27178	2	50	31
E-F	-115.4841	22.7563	-676.561	-769.2888	218	27	28	27253	2	49	30
E-G	-96.5461	-104.6034	-273.04	-474.1895	126	29	4	11121	8	24	27
E-H	-19.2439	0.0	-98.0858	-117.3297	65	2	11	4102	0	2	8
F-G	-16.6925	0.0	-103.99	-120.6825	69	3	11	4146	0	2	7
F-H	-64.81	-98.6022	-269.787	-433.1992	130	25	4	11350	9	27	31
G-H	-102.4766	36.7632	-677.969	-743.6824	215	21	28	27211	2	49	31

Interface residues

• A-B: ALA165A, ALA165B, ALA170A, ALA170B, ALA189A, ALA189B, ALA216A, ALA216B, ALA238A, ALA238B, ALA242A, ALA242B, ALA250A, ALA250B, ALA47A, ALA47B, ALA51A, ALA51B, ALA54A, ALA54B, ALA60A, ALA60B, ARG15A, ARG15B, ARG243A, ARG243B, ARG254A, ARG254B, ARG49A, ARG49B, ASN11A, ASN11B, ASN125A, ASN125B, ASN212A, ASN212B, ASN236A, ASN236B, ASP127A, ASP127B, ASP187A, ASP187B, ASP197A, ASP197B, ASP218A, ASP218B, ASP235A, ASP235B, ASP251A, ASP251B, ASP9A, ASP9B, CYS128A, CYS128B, CYS183A, CYS183B, GLN228A, GLN228B, GLU192A, GLU192B, GLU213A, GLU213B, GLY122A, GLY122B, GLY133A, GLY133B, GLY168A, GLY168B, GLY191A, GLY191B, GLY214A, GLY214B, GLY241A, GLY241B, GLY246A, GLY246B, GLY259A, GLY259B, GLY52A, GLY52B, GLY58A, GLY58B, GLY61A, GLY61B, HIS253A, HIS253B, HIS55A, HIS55B, ILE126A, ILE126B, ILE190A, ILE190B, ILE194A, ILE194B, ILE208A, ILE208B, ILE227A, ILE227B, ILE53A, ILE53B, ILE59A, ILE59B, LEU120A, LEU120B, LEU129A, LEU129B, LEU166A, LEU166B, LEU173A, LEU173B, LEU186A, LEU186B, LEU195A, LEU195B, LEU211A, LEU211B, LEU256A, LEU256B, LEU56A, LEU56B, LEU73A, LEU73B, LYS198A, LYS198B, LYS207A, LYS207B, LYS217A, LYS217B, LYS230A, LYS230B, LYS231A, LYS231B, LYS269A, LYS269B, LYS274A, LYS274B, LYS50A, LYS50B, MET172A, MET172B, MET185A, MET185B, PHE184A, PHE184B, PHE193A, PHE193B, PHE219A, PHE219B, PHE232A, PHE232B, PRO188A, PRO188B, PRO233A, PRO233B, PRO234A, PRO234B, PRO239A, PRO239B, SER123A, SER123B, SER124A, SER124B, SER131A, SER131B, SER169A, SER169B, SER210A, SER210B, SER237A, SER237B, SER247A, SER247B, SER45A, SER45B, SER46A, SER46B, THR12A, THR12B, THR171A, THR171B, THR224A, THR224B, THR255A, THR255B, TYR164A, TYR164B, TYR167A, TYR167B, TYR209A, TYR209B, TYR215A, TYR215B, TYR240A, TYR240B, TYR244A, TYR244B, TYR258A, TYR258B, TYR264A, TYR264B, TYR57A, TYR57B, VAL10A, VAL10B, VAL130A, VAL130B, VAL132A, VAL132B, VAL174A, VAL174B, VAL196A, VAL196B, VAL245A, VAL245B, VAL249A, VAL249B, VAL252A, VAL252B, VAL257A, VAL257B, VAL48A, VAL48B
• A-C: ALA189A, ALA189C, ALA40A, ALA40C, ALA43A, ALA43C, ALA47A, ALA47C, ALA51A, ALA51C, ALA90A, ALA90C, ARG15A, ARG15C, ARG22A, ARG22C, ARG25A, ARG25C, ASN11A, ASN11C, ASN35A, ASN35C, ASN83A, ASN83C, ASP187A, ASP187C, ASP9A, ASP9A5, ASP9C, CB8.27752-1.97461, CB8.35808-34.13316, CYS38A, CYS38C, GLN32A, GLN32C, GLU106C, GLU192A, GLU192C, GLU19A, GLU19C, GLU20A, GLU20C, GLU29A, GLU29C, GLY111A, GLY111C, GLY191A, GLY191C, GLY21A, GLY21C, GLY26A, GLY26C, GLY28A, GLY28C, ILE190A, ILE190C, ILE194A, ILE194C, ILE44A, ILE44C, LEU13A, LEU13C, LEU186A, LEU186C, LEU30A, LEU30C, LEU33A, LEU33C, LEU34A, LEU34C, LEU37A, LEU37C, LEU80A, LEU80C, LEU85A, LEU85C, LYS109A, LYS109C, LYS112A, LYS112C, LYS23A, LYS23C, LYS42A, LYS42C, LYS86A, LYS86C, MET18A, MET18C, MET84A, MET84C, PHE16A, PHE16C, PHE193A, PHE193C, PHE89A, PHE89C, PRO188A, PRO188C, SER36A, SER36C, SER45A, SER45C, SER46A, SER46C, SER87A, SER87C, SER88A, SER88C, THR12A, THR12C, THR14A, THR14C, THR27A, THR27C, THR31A, THR31C, THR39A, THR39C, THR91A, TYR113A, TYR113C, VAL10A, VAL10C, VAL17A, VAL17C, VAL41A, VAL41C
• A-D: ALA189A, ALA189D, ALA40A, ALA40D, ALA43A, ALA43D, ALA47A, ALA47D, ALA51A, ALA51D, ALA54A, ALA54D, ALA60A, ALA60D, ASN78A, ASN78D, ASN83A, ASN83D, ASP79A, ASP79D, CYS38A, CYS38D, GLY52A, GLY52D, GLY58A, GLY58D, GLY61A, GLY61D, HIS55A, HIS55D, ILE44A, ILE44D, ILE59A, ILE59D, LEU76A, LEU76D, LEU80A, LEU80D, LEU85D, LYS42A, LYS42D, LYS71A, LYS86A, MET82A, MET82D, MET84A, MET84D, PRO188A, PRO188D, SER36A, SER36D, SER46A, SER46D, SER77A, SER77D, SER87A, SER87D, THR39A, THR39D, TYR57A, TYR57D, VAL41A, VAL41D, VAL75A, VAL75D, VAL81A, VAL81D
• B-C: ALA189B, ALA189C, ALA40B, ALA40C, ALA43B, ALA43C, ALA47B, ALA47C, ALA51B, ALA51C, ALA54B, ALA54C, ALA60B, ALA60C, ASN78B, ASN78C, ASN83B, ASN83C, ASP79B, ASP79C, CYS38B, GLY52B, GLY52C, GLY58B, GLY58C, GLY61B, GLY61C, HIS55B, HIS55C, ILE44B, ILE44C, ILE59B, ILE59C, LEU76B, LEU76C, LEU80B, LEU80C, LEU85B, LYS42B, LYS42C, LYS72B, LYS86B, LYS86C, MET82B, MET82C, MET84B, MET84C, PRO188B, PRO188C, SER36B, SER36C, SER46B, SER46C, SER77B, SER77C, SER87B, SER87C, THR39B, THR39C, TYR57B, TYR57C, VAL41B, VAL41C, VAL75B, VAL75C, VAL81B, VAL81C
• B-D: ALA189B, ALA189D, ALA40B, ALA40D, ALA43B, ALA43D, ALA47B, ALA47D, ALA51B, ALA51D, ALA90B, ALA90D, ARG15B, ARG15D, ARG22B, ARG22D, ARG25B, ARG25D, ASN11B, ASN11D, ASN35B, ASN35D, ASN83B, ASN83D, ASP187B, ASP187D, ASP9B, ASP9D, CYS38B, CYS38D, GLN32B, GLN32D, GLU106B, GLU108D, GLU192B, GLU192D, GLU19B, GLU19D, GLU20B, GLU20D, GLU29B, GLU29D, GLY111B, GLY111D, GLY191B, GLY191D, GLY21B, GLY21D, GLY26B, GLY26D, GLY28B, GLY28D, ILE190B, ILE190D, ILE194B, ILE194D, ILE44B, ILE44D, LEU13B, LEU13D, LEU186B, LEU186D, LEU30B, LEU30D, LEU33B, LEU33D, LEU34B, LEU34D, LEU37B, LEU37D, LEU80B, LEU80D, LEU85B, LEU85D, LYS109B, LYS109D, LYS112B, LYS112D, LYS23B, LYS23D, LYS42B, LYS42D, LYS86B, LYS86D, MET18B, MET18D, MET82B, MET82D, MET84B, MET84D, PHE16B, PHE16D, PHE193B, PHE193D, PHE89B, PHE89D, PRO188B, PRO188D, SER36B, SER36D, SER45B, SER45D, SER46B, SER46D, SER87B, SER87D, SER88B, SER88D, THR12B, THR12D, THR14B, THR14D, THR27B, THR27D, THR31B, THR31D, THR39B, THR39D, THR91D, TYR113B, TYR113D, VAL10B, VAL10D, VAL17B, VAL17D, VAL41B, VAL41D, VAL81B, VAL81D
• B-E: ARG229B, ASN125E, ASN236B, ASP127E, ASP235B, ASP74E, LYS329B, LYS333B, LYS71E, LYS72E, PRO234B, SER124E, SER237B, SER335B, TYR215E, VAL70E
• B-F: ALA238F, ASP220B, GLY241F, HIS334B, ILE208F, LYS203F, LYS207F, LYS268B, LYS333B, PRO221B, PRO239F, SER237F, SER335B, TYR258F, TYR331B, VAL257F
• C-D: ALA165D, ALA170C, ALA170D, ALA189C, ALA189D, ALA216C, ALA216D, ALA238C, ALA238D, ALA242C, ALA242D, ALA250C, ALA250D, ALA47C, ALA47D, ALA51C, ALA51D, ALA54C, ALA54D, ALA60C, ALA60D, ARG15C, ARG15D, ARG243C, ARG243D, ARG254C, ARG254D, ARG49C, ARG49D, ASN11C, ASN11D, ASN125C, ASN125D, ASN212C, ASN212D, ASN236C, ASN236D, ASP127C, ASP127D, ASP187C, ASP187D, ASP197C, ASP197D, ASP218C, ASP218D, ASP235D, ASP251C, ASP251D, ASP9C, ASP9D, CYS128C, CYS128D, CYS183C, CYS183D, GLN228C, GLN228D, GLU192C, GLU192D, GLU213C, GLU213D, GLY122C, GLY133C, GLY133D, GLY168C, GLY168D, GLY191C, GLY191D, GLY214C, GLY214D, GLY241C, GLY241D, GLY246C, GLY246D, GLY52C, GLY52D, GLY58C, GLY58D, GLY61C, GLY61D, HIS253C, HIS253D, HIS55C, HIS55D, ILE126C, ILE126D, ILE190C, ILE190D, ILE194C, ILE194D, ILE208C, ILE208D, ILE227C, ILE227D, ILE53C, ILE53D, ILE59C, ILE59D, LEU120C, LEU120D, LEU129C, LEU129D, LEU166C, LEU166D, LEU173C, LEU173D, LEU186C, LEU186D, LEU195C, LEU195D, LEU211C, LEU211D, LEU256C, LEU256D, LEU56C, LEU56D, LEU73C, LEU73D, LYS198C, LYS198D, LYS207C, LYS207D, LYS217C, LYS217D, LYS230C, LYS230D, LYS231C, LYS231D, LYS269C, LYS269D, LYS274C, LYS50C, LYS50D, MET172C, MET172D, MET185C, MET185D, PHE184C, PHE184D, PHE193C, PHE193D, PHE219C, PHE219D, PHE232C, PHE232D, PRO188C, PRO188D, PRO233C, PRO233D, PRO239C, PRO239D, SER123C, SER123D, SER124C, SER124D, SER131C, SER131D, SER169C, SER169D, SER210C, SER210D, SER237C, SER237D, SER247C, SER247D, SER45C, SER45D, SER46C, SER46D, THR12C, THR12D, THR171C, THR171D, THR224C, THR224D, THR255C, THR255D, TYR164C, TYR164D, TYR167C, TYR167D, TYR209C, TYR209D, TYR215C, TYR215D, TYR240C, TYR240D, TYR244C, TYR244D, TYR258C, TYR258D, TYR264C, TYR264D, TYR57C, TYR57D, VAL10C, VAL10D, VAL130C, VAL130D, VAL132C, VAL132D, VAL174C, VAL174D, VAL196C, VAL196D, VAL245C, VAL245D, VAL249C, VAL249D, VAL252C, VAL252D, VAL257C, VAL257D, VAL48C, VAL48D
• E-F: ALA165E, ALA165F, ALA170E, ALA170F, ALA189E, ALA189F, ALA216E, ALA216F, ALA238E, ALA238F, ALA242E, ALA242F, ALA250E, ALA250F, ALA47E, ALA47F, ALA51E, ALA51F, ALA54E, ALA54F, ALA60E, ALA60F, ARG15E, ARG15F, ARG229F, ARG243E, ARG243F, ARG254E, ARG254F, ARG49E, ARG49F, ASN11E, ASN11F, ASN125E, ASN125F, ASN212E, ASN212F, ASN236E, ASN236F, ASP127E, ASP127F, ASP187E, ASP187F, ASP197E, ASP197F, ASP218E, ASP218F, ASP251E, ASP251F, ASP9E, ASP9F, CYS128E, CYS128F, CYS183E, CYS183F, GLN228E, GLN228F, GLU192E, GLU192F, GLU213E, GLU213F, GLY122F, GLY133E, GLY133F, GLY168E, GLY168F, GLY191E, GLY191F, GLY214E, GLY214F, GLY241E, GLY241F, GLY246E, GLY246F, GLY259E, GLY259F, GLY52E, GLY52F, GLY58E, GLY58F, GLY61E, GLY61F, HIS253E, HIS253F, HIS55E, HIS55F, ILE126E, ILE126F, ILE190E, ILE190F, ILE194E, ILE194F, ILE208E, ILE208F, ILE227E, ILE227F, ILE53E, ILE53F, ILE59E, ILE59F, LEU120E, LEU120F, LEU129E, LEU129F, LEU166E, LEU166F, LEU173E, LEU173F, LEU186E, LEU186F, LEU195E, LEU195F, LEU211E, LEU211F, LEU256E, LEU256F, LEU56E, LEU56F, LEU73E, LEU73F, LYS198E, LYS198F, LYS207E, LYS207F, LYS217E, LYS217F, LYS230E, LYS230F, LYS231E, LYS231F, LYS269F, LYS274E, LYS274F, LYS50E, LYS50F, MET172E, MET172F, MET185E, MET185F, PHE184E, PHE184F, PHE193E, PHE193F, PHE219E, PHE219F, PHE232E, PHE232F, PRO188E, PRO188F, PRO233E, PRO233F, PRO234F, PRO239E, PRO239F, SER123E, SER123F, SER124E, SER124F, SER131E, SER131F, SER169E, SER169F, SER210E, SER210F, SER237E, SER237F, SER247E, SER247F, SER45E, SER45F, SER46E, SER46F, THR12E, THR12F, THR171E, THR171F, THR224E, THR224F, THR255E, THR255F, TYR164E, TYR164F, TYR167E, TYR167F, TYR209E, TYR209F, TYR215E, TYR215F, TYR240E, TYR240F, TYR244E, TYR244F, TYR258E, TYR258F, TYR264E, TYR264F, TYR57E, TYR57F, VAL10E, VAL10F, VAL130E, VAL130F, VAL132E, VAL132F, VAL174E, VAL174F, VAL196E, VAL196F, VAL245E, VAL245F, VAL249E, VAL249F, VAL252E, VAL252F, VAL257E, VAL257F, VAL48E, VAL48F
• E-G: ALA189E, ALA189G, ALA40E, ALA40G, ALA43E, ALA43G, ALA47E, ALA47G, ALA51E, ALA51G, ALA90E, ALA90G, ARG15E, ARG15G, ARG22E, ARG22G, ARG25E, ARG25G, ASN11E, ASN11G, ASN35E, ASN35G, ASN83E, ASN83G, ASP187E, ASP187G, ASP9E, ASP9G, CYS38E, CYS38G, GLN32E, GLN32G, GLU106E, GLU106G, GLU192E, GLU192G, GLU19E, GLU19G, GLU20E, GLU20G, GLU29E, GLU29G, GLY111E, GLY111G, GLY191E, GLY191G, GLY21E, GLY21G, GLY26E, GLY26G, GLY28E, GLY28G, GLY52E, ILE190E, ILE190G, ILE194E, ILE194G, ILE44E, ILE44G, LEU13E, LEU13G, LEU186E, LEU186G, LEU30E, LEU30G, LEU33E, LEU33G, LEU34E, LEU34G, LEU37E, LEU37G, LEU80E, LEU80G, LEU85E, LEU85G, LYS109E, LYS109G, LYS112E, LYS112G, LYS23E, LYS23G, LYS42E, LYS42G, LYS86E, LYS86G, MET18E, MET18G, MET82G, MET84E, MET84G, PHE16E, PHE16G, PHE193E, PHE193G, PHE89E, PHE89G, PRO188E, PRO188G, SER36E, SER36G, SER45E, SER45G, SER46E, SER46G, SER87E, SER87G, SER88E, SER88G, THR12E, THR12G, THR14E, THR14G, THR27E, THR27G, THR31E, THR31G, THR39E, THR39G, TYR113G, VAL10E, VAL10G, VAL17E, VAL17G, VAL41E, VAL41G, VAL81G
• E-H: ALA189E, ALA189H, ALA40E, ALA40H, ALA43E, ALA43H, ALA47E, ALA47H, ALA51E, ALA51H, ALA54E, ALA54H, ALA60E, ALA60H, ASN78E, ASN78H, ASN83E, ASN83H, ASP79E, ASP79H, GLY52E, GLY52H, GLY58E, GLY58H, GLY61E, GLY61H, HIS55E, HIS55H, ILE44E, ILE44H, ILE59E, ILE59H, LEU76E, LEU76H, LEU80E, LEU80H, LEU85H, LYS42E, LYS42H, LYS71E, LYS86E, MET82E, MET82H, MET84E, MET84H, PRO188E, PRO188H, SER36E, SER36H, SER46E, SER46H, SER77E, SER77H, SER87E, SER87H, THR39E, THR39H, TYR57E, TYR57H, VAL41E, VAL41H, VAL75E, VAL75H, VAL81E, VAL81H
• F-G: ALA189F, ALA189G, ALA40F, ALA40G, ALA43F, ALA43G, ALA47F, ALA47G, ALA51F, ALA51G, ALA54F, ALA54G, ALA60F, ALA60G, ASN78F, ASN78G, ASN83F, ASN83G, ASP79F, ASP79G, CYS38F, CYS38G, GLY52F, GLY52G, GLY58F, GLY58G, GLY61F, GLY61G, HIS55F, HIS55G, ILE44F, ILE44G, ILE59F, ILE59G, LEU76F, LEU76G, LEU80F, LEU80G, LEU85F, LEU85G, LYS42F, LYS42G, LYS72F, LYS86F, LYS86G, MET82F, MET82G, MET84F, MET84G, PRO188F, PRO188G, SER36F, SER36G, SER46F, SER46G, SER77F, SER77G, SER87F, SER87G, THR39F, THR39G, TYR57F, TYR57G, VAL41F, VAL41G, VAL75F, VAL75G, VAL81F, VAL81G
• F-H: ALA189F, ALA189H, ALA40F, ALA40H, ALA43F, ALA43H, ALA47F, ALA47H, ALA51F, ALA51H, ALA90F, ALA90H, ARG110F, ARG15F, ARG15H, ARG22F, ARG22H, ARG25F, ARG25H, ASN11F, ASN11H, ASN35F, ASN35H, ASN83F, ASN83H, ASP187F, ASP187H, ASP9F, ASP9H, CYS38F, CYS38H, GLN32F, GLN32H, GLU108F, GLU192F, GLU192H, GLU19F, GLU19H, GLU20F, GLU20H, GLU29F, GLU29H, GLY111F, GLY111H, GLY191F, GLY191H, GLY21F, GLY21H, GLY26F, GLY26H, GLY28F, GLY28H, GLY52F, ILE190F, ILE190H, ILE194F, ILE194H, ILE44F, ILE44H, LEU13F, LEU13H, LEU186F, LEU186H, LEU30F, LEU30H, LEU33F, LEU33H, LEU34F, LEU34H, LEU37F, LEU37H, LEU80F, LEU80H, LEU85F, LEU85H, LYS109F, LYS109H, LYS112F, LYS112H, LYS23F, LYS23H, LYS42F, LYS42H, LYS86F, LYS86H, MET18F, MET18H, MET82F, MET82H, MET84F, MET84H, PHE16F, PHE16H, PHE193F, PHE193H, PHE89F, PHE89H, PRO188F, PRO188H, SER36F, SER36H, SER45F, SER45H, SER46F, SER46H, SER87F, SER87H, SER88F, SER88H, THR12F, THR12H, THR14F, THR14H, THR27F, THR27H, THR31F, THR31H, THR39F, THR39H, THR91H, TYR113F, TYR113H, VAL10F, VAL10H, VAL17F, VAL17H, VAL41F, VAL41H, VAL81F, VAL81H
• G-H: ALA165H, ALA170G, ALA170H, ALA189G, ALA189H, ALA216G, ALA216H, ALA238G, ALA238H, ALA242G, ALA242H, ALA250G, ALA250H, ALA47G, ALA47H, ALA51G, ALA51H, ALA54G, ALA54H, ALA60G, ALA60H, ARG15G, ARG15H, ARG243G, ARG243H, ARG254G, ARG254H, ARG49G, ARG49H, ASN11G, ASN11H, ASN125G, ASN125H, ASN212G, ASN212H, ASN236G, ASN236H, ASP127G, ASP127H, ASP187G, ASP187H, ASP197G, ASP197H, ASP218G, ASP218H, ASP235H, ASP251G, ASP251H, ASP9G, ASP9H, CYS128G, CYS128H, CYS183G, CYS183H, GLN228G, GLN228H, GLU192G, GLU192H, GLU213G, GLU213H, GLY122H, GLY133G, GLY133H, GLY168G, GLY168H, GLY191G, GLY191H, GLY214G, GLY214H, GLY241G, GLY241H, GLY246G, GLY246H, GLY259H, GLY52G, GLY52H, GLY58G, GLY58H, GLY61G, GLY61H, HIS253G, HIS253H, HIS55G, HIS55H, ILE126G, ILE126H, ILE190G, ILE190H, ILE194G, ILE194H, ILE208G, ILE208H, ILE227G, ILE227H, ILE53G, ILE53H, ILE59G, ILE59H, LEU120G, LEU120H, LEU129G, LEU129H, LEU166G, LEU166H, LEU173G, LEU173H, LEU186G, LEU186H, LEU195G, LEU195H, LEU211G, LEU211H, LEU256G, LEU256H, LEU56G, LEU56H, LEU73G, LEU73H, LYS198G, LYS198H, LYS207G, LYS207H, LYS217G, LYS217H, LYS230G, LYS230H, LYS231G, LYS231H, LYS269G, LYS274G, LYS50G, LYS50H, MET172G, MET172H, MET185G, MET185H, PHE184G, PHE184H, PHE193G, PHE193H, PHE219G, PHE219H, PHE232G, PHE232H, PRO188G, PRO188H, PRO233G, PRO233H, PRO234G, PRO239G, PRO239H, SER123G, SER123H, SER124G, SER124H, SER131G, SER131H, SER169G, SER169H, SER210G, SER210H, SER237G, SER237H, SER247G, SER247H, SER45G, SER45H, SER46G, SER46H, THR12G, THR12H, THR171G, THR171H, THR224G, THR224H, THR255G, THR255H, TYR164G, TYR164H, TYR167G, TYR167H, TYR209G, TYR209H, TYR215G, TYR215H, TYR240G, TYR240H, TYR244G, TYR244H, TYR258G, TYR258H, TYR264G, TYR264H, TYR57G, TYR57H, VAL10G, VAL10H, VAL130G, VAL130H, VAL132G, VAL132H, VAL174G, VAL174H, VAL196G, VAL196H, VAL245G, VAL245H, VAL249G, VAL249H, VAL252G, VAL252H, VAL257G, VAL257H, VAL48G, VAL48H