2Y1M

structure of native c-cbl

• Total interactions analyzed: 15
• Total true interactions: 9
• Strongest Interaction:
  • Chains: A-F
  • Int. Res.: 154
  • Norm. En. per Res.: -2.507
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	0.0	8.1568	-93.9086	-85.7518	51	2	1	4625	2	15	25
A-E	-89.0841	5.2504	-307.272	-391.1057	158	30	3	14527	5	56	50
A-F	-69.7095	-10.5556	-305.813	-386.0781	154	19	3	13393	9	51	47
B-C	-23.7704	15.5277	-310.048	-318.2907	153	22	3	14193	4	53	47
B-E	0.0	26.1176	-3.3235	22.7941	10	0	0	133	0	3	5
C-D	-44.898	8.3496	-290.413	-326.9614	160	21	3	13265	5	50	49
C-E	0.0	0.0	-1.6233	-1.6233	7	0	0	132	0	3	4
C-F	0.0	0.0	-0.2943	-0.2943	7	0	0	53	0	3	4
D-F	-6.5215	1.805	-103.273	-107.9895	50	8	1	4704	3	15	25

Interface residues

• A-C: ALA310A, ARG139C, ARG333A, ARG343A, ARG68C, ASN313A, ASN344A, ASN346A, ASN72C, ASP311A, ASP330A, ASP64C, GLN345A, GLN71C, GLU135C, GLU138C, GLU334A, GLY136C, GLY289A, GLY312A, GLY331A, GLY335A, HIS286A, ILE130C, ILE285A, ILE329A, LEU132C, LEU338A, LEU69C, LEU75C, LYS134C, LYS137C, LYS283A, LYS287A, LYS65C, LYS74C, MET140C, PHE133C, PHE284A, PHE332A, PHE336A, PHE339A, PRO288A, PRO73C, SER131C, SER290A, THR309A, TYR141C, TYR337A, VAL308A, VAL66C
• A-E: ALA163E, ALA184E, ALA186E, ALA187E, ALA193E, ALA304E, ALA327E, ARG101E, ARG149A, ARG180E, ARG191E, ARG246E, ARG280A, ARG294E, ARG299E, ARG343A, ASN144A, ASN321E, ASN344A, ASN346A, ASN79E, ASP177E, ASP185E, ASP242E, ASP275E, ASP330E, ASP341A, ASP348A, ASP359A, ASP390A, ASP432A, ASP435A, ASP86E, ASP90E, CYS297E, CYS396A, CYS421A, GLN146A, GLN175E, GLN302E, GLN316E, GLN326E, GLN345A, GLN365A, GLN367A, GLN379A, GLU164E, GLU188E, GLU196E, GLU334E, GLU366A, GLU369A, GLU373A, GLU394A, GLU422A, GLU427A, GLY167E, GLY172E, GLY195E, GLY267A, GLY301E, GLY331E, GLY335E, GLY342A, GLY397A, GLY425A, HIS265A, HIS320E, HIS360A, HIS398A, HIS94E, ILE168E, ILE181E, ILE243E, ILE305E, ILE314E, ILE318E, ILE329E, ILE361A, ILE393A, ILE423A, ILE429A, ILE84E, LEU165E, LEU173E, LEU272E, LEU295E, LEU300E, LEU315E, LEU328E, LEU370A, LEU380A, LEU399A, LEU85E, LEU87E, LYS105E, LYS166E, LYS183E, LYS192E, LYS278E, LYS283A, LYS287A, LYS322E, LYS362A, LYS389A, LYS392A, LYS424A, PHE169E, PHE174E, PHE179E, PHE189E, PHE239E, PHE284A, PHE332E, PHE336E, PHE339A, PHE378A, PHE434A, PRO170E, PRO266A, PRO319E, PRO340A, PRO347A, PRO395A, PRO428A, PRO433A, PRO81E, PRO82E, SER159E, SER171E, SER216A, SER217A, SER296E, SER80E, THR178E, THR182E, THR264A, THR273E, THR298E, THR309E, THR317E, THR364A, THR377A, THR426A, TRP190E, TRP303E, TYR274E, TYR291A, TYR307E, TYR337E, TYR368A, TYR83E, VAL263A, VAL277E, VAL363A, VAL391A, VAL430A, VAL431A
• A-F: ALA163A, ALA184A, ALA186A, ALA187A, ALA304A, ALA327A, ARG101A, ARG149F, ARG180A, ARG191A, ARG246A, ARG294A, ARG299A, ARG333A, ARG343F, ASN259F, ASN321A, ASN344F, ASN346F, ASN79A, ASP177A, ASP185A, ASP242A, ASP275A, ASP330A, ASP341F, ASP348F, ASP359F, ASP432F, ASP435F, ASP86A, ASP90A, CYS297A, CYS396F, CYS419F, CYS421F, GLN146F, GLN175A, GLN302A, GLN316A, GLN326A, GLN345F, GLN365F, GLN367F, GLN379F, GLU188A, GLU196A, GLU220F, GLU334A, GLU366F, GLU369F, GLU373F, GLU394F, GLU422F, GLU427F, GLY167A, GLY172A, GLY195A, GLY267F, GLY301A, GLY331A, GLY335A, GLY342F, GLY397F, GLY425F, HIS265F, HIS320A, HIS360F, HIS398F, HIS94A, ILE168A, ILE181A, ILE243A, ILE305A, ILE314A, ILE318A, ILE329A, ILE361F, ILE393F, ILE429F, LEU165A, LEU173A, LEU272A, LEU295A, LEU300A, LEU315A, LEU328A, LEU349F, LEU370F, LEU399F, LEU85A, LEU87A, LYS105A, LYS166A, LYS183A, LYS192A, LYS278A, LYS283F, LYS287F, LYS322A, LYS362F, LYS389F, LYS392F, LYS424F, MET400F, PHE169A, PHE174A, PHE179A, PHE189A, PHE239A, PHE284F, PHE332A, PHE336A, PHE378F, PHE434F, PRO170A, PRO214F, PRO266F, PRO319A, PRO340F, PRO347F, PRO395F, PRO428F, PRO433F, PRO81A, PRO82A, SER171A, SER216F, SER217F, SER260F, SER296A, SER80A, THR178A, THR182A, THR264F, THR273A, THR298A, THR309A, THR317A, THR364F, THR377F, THR426F, TRP190A, TYR102A, TYR274A, TYR307A, TYR337A, TYR368F, TYR83A, VAL263F, VAL363F, VAL391F, VAL430F, VAL431F
• B-C: ALA163C, ALA184C, ALA186C, ALA187C, ALA304C, ALA327C, ARG101C, ARG149B, ARG180C, ARG191C, ARG246C, ARG280B, ARG294C, ARG299C, ARG333C, ARG343B, ASN321C, ASN344B, ASN346B, ASN79C, ASP177C, ASP185C, ASP242C, ASP275C, ASP330C, ASP341B, ASP348B, ASP390B, ASP432B, ASP435B, ASP86C, ASP90C, CYS297C, CYS396B, CYS421B, GLN175C, GLN302C, GLN316C, GLN326C, GLN345B, GLN365B, GLN367B, GLN379B, GLU188C, GLU196C, GLU220B, GLU334C, GLU366B, GLU369B, GLU373B, GLU394B, GLU422B, GLU427B, GLY167C, GLY172C, GLY195C, GLY267B, GLY331C, GLY335C, GLY342B, GLY397B, GLY425B, HIS265B, HIS320C, HIS360B, HIS398B, HIS94C, ILE168C, ILE181C, ILE243C, ILE305C, ILE314C, ILE318C, ILE329C, ILE361B, ILE393B, ILE423B, ILE429B, LEU165C, LEU173C, LEU272C, LEU295C, LEU300C, LEU315C, LEU328C, LEU349B, LEU370B, LEU399B, LEU85C, LEU87C, LYS166C, LYS183C, LYS192C, LYS278C, LYS283B, LYS287B, LYS322C, LYS362B, LYS382B, LYS389B, LYS392B, LYS424B, LYS78C, MET374B, MET400B, PHE169C, PHE174C, PHE179C, PHE239C, PHE284B, PHE332C, PHE336C, PHE339B, PHE378B, PHE434B, PRO170C, PRO266B, PRO319C, PRO340B, PRO347B, PRO395B, PRO428B, PRO433B, PRO81C, PRO82C, SER171C, SER216B, SER217B, SER296C, SER376B, SER80C, THR178C, THR182C, THR264B, THR273C, THR298C, THR309C, THR317C, THR364B, THR377B, THR426B, TRP190C, TRP303C, TYR274C, TYR307C, TYR337C, TYR368B, TYR83C, VAL263B, VAL363B, VAL391B, VAL430B, VAL431B
• B-E: GLN207B, GLN207E, GLN414B, GLN414E, GLU412B, GLU412E, LYS203B, LYS203E, SER411B, SER411E
• C-D: ALA163D, ALA184D, ALA186D, ALA187D, ALA304D, ALA327D, ARG101D, ARG149C, ARG180D, ARG191D, ARG246D, ARG294D, ARG299D, ARG333D, ARG343C, ASN259C, ASN321D, ASN344C, ASN346C, ASN79D, ASP177D, ASP185D, ASP242D, ASP275D, ASP330D, ASP341C, ASP348C, ASP359C, ASP390C, ASP432C, ASP435C, ASP86D, ASP90D, CYS297D, CYS396C, CYS421C, GLN146C, GLN175D, GLN302D, GLN316D, GLN326D, GLN345C, GLN365C, GLN367C, GLN379C, GLU188D, GLU196D, GLU334D, GLU366C, GLU369C, GLU373C, GLU394C, GLU422C, GLU427C, GLY167D, GLY172D, GLY195D, GLY267C, GLY301D, GLY331D, GLY335D, GLY342C, GLY397C, GLY425C, HIS265C, HIS320D, HIS360C, HIS398C, HIS94D, ILE168D, ILE181D, ILE243D, ILE305D, ILE314D, ILE318D, ILE329D, ILE361C, ILE393C, ILE423C, ILE429C, LEU165D, LEU173D, LEU219C, LEU272D, LEU295D, LEU300D, LEU315D, LEU328D, LEU370C, LEU399C, LEU77D, LEU85D, LEU87D, LYS105D, LYS166D, LYS183D, LYS192D, LYS278D, LYS283C, LYS287C, LYS322D, LYS362C, LYS389C, LYS392C, LYS424C, LYS78D, MET374C, MET400C, PHE169D, PHE174D, PHE179D, PHE189D, PHE239D, PHE284C, PHE332D, PHE336D, PHE378C, PHE434C, PRO170D, PRO266C, PRO319D, PRO340C, PRO347C, PRO395C, PRO428C, PRO433C, PRO81D, PRO82D, SER159D, SER171D, SER216C, SER217C, SER260C, SER296D, SER376C, SER80D, THR178D, THR182D, THR264C, THR273D, THR298D, THR309D, THR317D, THR364C, THR377C, THR426C, TRP190D, TRP303D, TYR102D, TYR274D, TYR307D, TYR337D, TYR368C, TYR83D, VAL263C, VAL277D, VAL363C, VAL391C, VAL430C, VAL431C
• C-E: ARG68C, GLN71C, GLU188E, LEU85C, LYS192E, PRO89C, VAL67C
• C-F: ASP435C, ASP435F, GLU138C, GLU138F, PHE434C, PHE434F, PRO433C
• D-F: ALA310D, ARG139F, ARG333D, ARG68F, ASN313D, ASN344D, ASN346D, ASN72F, ASP311D, ASP330D, CYS70F, GLN345D, GLN71F, GLU135F, GLU138F, GLU334D, GLY136F, GLY289D, GLY312D, GLY331D, GLY335D, GLY342D, HIS286D, ILE130F, ILE285D, LEU132F, LEU338D, LEU69F, LEU75F, LYS134F, LYS137F, LYS283D, LYS287D, LYS61F, LYS65F, LYS74F, MET140F, PHE133F, PHE284D, PHE332D, PHE336D, PHE339D, PRO288D, PRO73F, SER131F, SER290D, THR309D, TYR141F, TYR337D, VAL308D