2Y0S

crystal structure of sulfolobus shibatae rna polymerase in p21 space group

• Total interactions analyzed: 325
• Total true interactions: 71
• Strongest Interaction:
  • Chains: T-Y
  • Int. Res.: 6
  • Norm. En. per Res.: -10.5406
• Hub Node: A(12)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-263.4165	-260.1431	-2110.69	-2634.2496	639	167	45	90736	19	213	194
A-C	-109.5048	-146.0192	-1017.17	-1272.694	334	102	47	49477	13	125	134
A-D	0.0	16.0743	-1.3338	14.7404	18	0	0	113	0	9	7
A-E	0.0	5.2624	-9.9864	-4.724	16	0	0	297	0	2	3
A-F	0.0	0.0	-0.0091	-0.0091	2	0	0	7	0	0	0
A-G	-52.1911	-43.2714	-332.036	-427.4985	121	25	8	14704	4	35	27
A-H	-8.0383	-15.0228	-128.912	-151.9731	58	17	6	6178	0	13	10
A-K	-4.0844	-15.1102	-236.436	-255.6306	121	17	7	11571	2	39	35
A-L	-26.5178	-29.3001	-185.939	-241.7569	77	5	2	7664	3	25	21
A-Q	0.0	3.6907	-34.7982	-31.1075	35	8	0	2189	0	22	20
A-V	0.0	0.0	-3.9731	-3.9731	12	0	0	401	0	1	1
A-Y	0.0	10.4714	-0.1681	10.3033	8	0	0	35	0	5	4
B-C	-15.7639	7.7395	-170.498	-178.5224	119	8	15	9627	0	16	18
B-D	-27.5558	-75.2682	-368.745	-471.569	148	27	5	15664	5	42	52
B-E	-12.731	6.307	-18.9312	-25.3552	25	7	2	1237	0	9	8
B-F	0.0	0.0	-2.7809	-2.7809	6	0	0	165	0	0	0
B-G	0.0	0.0	-0.0009	-0.0009	2	0	0	2	0	1	2
B-K	0.0	0.0	-7.4273	-7.4273	16	0	0	503	0	1	1
B-L	0.0	3.0215	-45.8487	-42.8272	34	5	0	2058	1	9	9
B-N	-27.5097	-44.5403	-416.375	-488.4251	141	28	9	18226	2	25	31
B-P	-25.968	-53.1026	-214.779	-293.8495	103	23	6	9894	2	43	24
C-E	-20.4916	-39.4629	-111.513	-171.4675	44	12	2	4664	1	7	8
C-H	-33.3818	-24.844	-263.694	-321.9198	105	21	9	11985	3	42	31
C-I	0.0	0.0	-0.0772	-0.0772	3	0	0	25	0	1	0
C-K	-27.8643	-41.8125	-239.249	-308.9258	83	25	10	10789	1	16	11
C-W	0.0	8.344	-0.2314	8.1126	8	0	0	42	0	5	4
C-Y	0.0	0.7873	-6.6619	-5.8746	19	0	0	600	0	8	9
C-Z	0.0	-8.6099			2
D-G	0.0	0.0	-0.1764	-0.1764	6	0	0	59	0	3	2
D-L	-41.6585	-118.3319	-348.755	-508.7455	119	20	18	16840	12	43	40
D-N	0.0	2.8983	-231.478	-228.5797	102	12	7	10967	1	19	17
D-P	-41.6668	-12.0031	-146.342	-200.012	52	13	12	5456	3	17	11
E-F	-41.6152	-28.9731	-404.507	-475.0952	142	49	24	18620	2	33	24
E-K	-2.3217	-5.7227	-108.48	-116.5243	44	11	2	4116	0	6	1
G-V	-5.741	0.0	-14.1398	-19.8808	19	0	0	779	0	10	9
G-W	0.0	0.0	-3.9551	-3.9551	12	0	0	405	0	1	1
H-K	0.0	-7.7474	-63.9268	-71.6743	36	3	0	2796	1	15	11
H-Q	-9.9989	-19.5734	-80.622	-110.1942	52	15	2	4573	2	23	22
H-Y	0.0	-7.4032	0.0	-7.4032	2	0	0	0	0	0	0
I-R	0.0	0.0	-7.0119	-7.0119	16	0	0	478	0	0	1
I-T	0.0	-5.4962	-105.585	-111.0812	44	11	2	4062	0	5	1
I-W	-4.0811	-15.6376	-242.815	-262.5337	121	20	7	11743	2	39	35
I-Y	-29.0818	-41.2715	-21.2768	-91.6301	33	5	2	1634	0	6	5
I-Z	0.0	-8.6964			8
J-W	0.0	3.5732	-33.4376	-29.8644	34	8	0	2198	0	21	20
J-Z	-10.2003	-17.113			7
M-R	0.0	3.3268	-46.5731	-43.2463	34	3	0	2111	1	9	9
M-S	-39.3229	-105.6476	-348.436	-493.4065	119	18	16	16767	12	43	39
M-W	-27.6441	-30.6381	-189.468	-247.7502	79	9	2	7766	3	26	22
N-P	0.0	13.1784	-14.4243	-1.2459	15	1	0	1008	0	2	5
O-R	-64.9663	-46.1817	-410.967	-522.115	145	34	9	18396	2	25	30
O-S	-5.4358	2.9427	-230.772	-233.2651	103	13	7	10970	1	19	16
O-X	0.0	13.384	-15.2197	-1.8357	14	1	0	1032	0	2	5
R-S	-18.4862	-75.16	-365.284	-458.9302	150	31	5	15626	5	42	52
R-T	-11.6354	6.2444	-20.1606	-25.5517	25	7	2	1175	0	9	7
R-U	0.0	0.0	-2.1382	-2.1382	6	0	0	139	0	0	0
R-V	0.0	0.0	-0.0012	-0.0012	2	0	0	3	0	1	2
R-W	-279.4614	-251.549	-2121.54	-2652.5504	638	158	43	91097	19	211	195
R-X	-26.2709	-54.8804	-213.214	-294.3653	103	29	6	10158	2	43	23
R-Y	0.0	7.8182	0.0	7.8182	2	0	0	0	0	0	0
S-V	0.0	0.0	-0.1894	-0.1894	6	0	0	62	0	3	2
S-W	0.0	16.0838	-1.3021	14.7817	17	0	0	110	0	9	7
S-X	-42.465	-43.3331	-150.212	-236.0101	53	16	12	5531	3	18	11
T-U	-37.8641	-22.5136	-385.99	-446.3676	141	49	24	18325	2	33	24
T-W	0.0	5.2735	-9.4807	-4.2072	15	0	0	287	0	2	3
T-Y	-22.2415	-41.0024	0.0	-63.2438	6	0	0	0	0	0	0
U-W	0.0	0.0	-0.011	-0.011	2	0	0	8	0	0	0
V-W	-68.1365	-41.1123	-331.973	-441.2219	121	24	8	14819	4	35	27
W-Y	-100.4673	-142.1737	-125.429	-368.07	113	21	1	7254	0	33	41
W-Z	-8.2685	-14.8569			8
Y-Z	-33.0236	-30.3034			20

Interface residues

• A-B: 4152CB6.7864, 5152CB6.1913, 6147CB9.7182, ALA1001B, ALA1006B, ALA1008B, ALA1045B, ALA1099B, ALA299A, ALA342B, ALA344A, ALA432A, ALA445B, ALA455A, ALA472A, ALA474A, ALA474B, ALA476A, ALA498A, ALA499A, ALA621B, ALA627B, ALA630B, ALA649B, ALA655B, ALA725A, ALA728B, ALA729A, ALA733A, ALA744A, ALA799A, ALA800A, ALA810A, ALA917B, ALA932B, ALA969B, ARG1007B, ARG1009B, ARG1017B, ARG1023B, ARG1025B, ARG1030B, ARG1036B, ARG1051B, ARG1058B, ARG1115B, ARG1121B, ARG13B, ARG203A, ARG20A, ARG220A, ARG293A, ARG301A, ARG308A, ARG310A, ARG317A, ARG323A, ARG333B, ARG345A, ARG385A, ARG421A, ARG427A, ARG438B, ARG444A, ARG446B, ARG455B, ARG48A, ARG580B, ARG633A, ARG637A, ARG647A, ARG668B, ARG734A, ARG745B, ARG753A, ARG759A, ARG764A, ARG779A, ARG784B, ARG787A, ARG803A, ARG821A, ARG836B, ARG921B, ARG977B, ARG985B, ASN1055B, ASN1076B, ASN1078B, ASN1090B, ASN312A, ASN331A, ASN343B, ASN376A, ASN420A, ASN442B, ASN454A, ASN463A, ASN466B, ASN472B, ASN485A, ASN5A, ASN605A, ASN626B, ASN63A, ASN664B, ASN669B, ASN67A, ASN723A, ASN736B, ASN739A, ASN825A, ASN914B, ASP1002B, ASP1037B, ASP1050B, ASP1054B, ASP1057B, ASP1065B, ASP1074B, ASP1120B, ASP17A, ASP278A, ASP319A, ASP329A, ASP336B, ASP337B, ASP339B, ASP387A, ASP447B, ASP456A, ASP458A, ASP460A, ASP501A, ASP564B, ASP620B, ASP635B, ASP650A, ASP655A, ASP739B, ASP773A, ASP808A, ASP829A, ASP879B, ASP968B, ASP975B, CYS1038B, CYS1067B, CYS1082B, CYS450A, CYS457B, CYS58A, CYS61A, CYS68A, GLN1013B, GLN1018B, GLN1066B, GLN1105B, GLN300A, GLN422A, GLN440B, GLN452B, GLN468A, GLN500A, GLN523A, GLN642A, GLN665B, GLN742A, GLN750A, GLN815A, GLN820A, GLN887B, GLN926B, GLN957B, GLN980B, GLU1021B, GLU1026B, GLU1033B, GLU1035B, GLU1106B, GLU1119B, GLU18A, GLU306A, GLU334B, GLU341A, GLU408A, GLU444B, GLU460B, GLU461A, GLU463B, GLU470A, GLU471A, GLU475A, GLU478A, GLU519A, GLU520A, GLU53A, GLU568B, GLU622B, GLU623B, GLU624B, GLU625B, GLU632B, GLU639B, GLU640A, GLU644B, GLU649A, GLU662B, GLU738B, GLU794A, GLU804A, GLU929B, GLU954B, GLU971B, GLY1010B, GLY1022B, GLY1027B, GLY1028B, GLY1032B, GLY1041B, GLY1043B, GLY1068B, GLY1071B, GLY1086B, GLY12A, GLY307A, GLY311A, GLY315A, GLY439B, GLY440A, GLY450B, GLY454B, GLY459A, GLY464B, GLY468B, GLY497A, GLY505A, GLY62A, GLY643A, GLY654A, GLY66A, GLY70A, GLY732A, GLY734B, GLY735A, GLY73A, GLY760A, GLY788B, GLY789A, GLY801A, GLY802A, GLY805A, GLY817A, GLY845B, GLY85A, GLY878B, GLY889B, GLY892B, GLY8A, GLY925B, GLY930B, GLY979B, HIS1005B, HIS1085B, HIS340B, HIS426A, HIS449B, HIS465A, HIS570B, HIS640B, HIS642B, HIS663B, HIS71A, HIS74A, HIS768A, HIS798A, HIS83A, HIS844B, HIS916B, HIS998B, ILE1004B, ILE1014B, ILE1040B, ILE1061B, ILE1070B, ILE1084B, ILE1104B, ILE1111B, ILE1112B, ILE1117B, ILE13A, ILE19A, ILE208A, ILE217A, ILE219A, ILE223A, ILE326A, ILE332A, ILE342A, ILE343A, ILE379A, ILE386A, ILE428A, ILE473A, ILE479A, ILE503A, ILE524A, ILE52A, ILE561B, ILE566B, ILE636A, ILE650B, ILE6A, ILE730B, ILE740A, ILE741B, ILE742B, ILE757A, ILE824A, ILE874B, ILE877B, ILE891B, ILE895B, ILE927B, ILE931B, ILE953B, ILE960B, ILE982B, ILE986B, ILE9A, LEU1015B, LEU1029B, LEU1039B, LEU1047B, LEU1048B, LEU1052B, LEU1053B, LEU1091B, LEU1102B, LEU1103B, LEU1107B, LEU1116B, LEU1118B, LEU14A, LEU209A, LEU212A, LEU235A, LEU239A, LEU298A, LEU302A, LEU313A, LEU347A, LEU411A, LEU418A, LEU425A, LEU438A, LEU441A, LEU445A, LEU447A, LEU448A, LEU448B, LEU464A, LEU469B, LEU481A, LEU508A, LEU515A, LEU516A, LEU582B, LEU619B, LEU631B, LEU641A, LEU643B, LEU648A, LEU651B, LEU65A, LEU738A, LEU747A, LEU766A, LEU790A, LEU795A, LEU806A, LEU827A, LEU830A, LEU841A, LEU894B, LEU913B, LEU918B, LEU924B, LEU996B, LYS1003B, LYS1049B, LYS1075B, LYS1077B, LYS10A, LYS1101B, LYS21A, LYS303A, LYS305A, LYS316A, LYS324B, LYS338B, LYS392A, LYS439A, LYS471B, LYS477A, LYS4A, LYS4A5, LYS658A, LYS758A, LYS770A, LYS787B, LYS789B, LYS791A, LYS7A, LYS880B, LYS888B, LYS950B, LYS981B, LYS983B, MET1034B, MET1046B, MET1108B, MET1110B, MET207A, MET224A, MET22A, MET430A, MET431A, MET456B, MET462A, MET480A, MET646A, MET675B, MET728A, MET737B, MET743A, MET762A, MET847B, MET858A, MET893B, MET922B, MET928B, MET999B, PHE1031B, PHE1042B, PHE1092B, PHE1100B, PHE11A, PHE277A, PHE309A, PHE320A, PHE419A, PHE443A, PHE443B, PHE457A, PHE459B, PHE632A, PHE638A, PHE644A, PHE724A, PHE72A, PHE732B, PHE769A, PHE786A, PHE796A, PHE797A, PHE856A, PHE86A, PHE881B, PHE948B, PHE988B, PRO1011B, PRO1019B, PRO1083B, PRO1093B, PRO1114B, PRO16A, PRO213A, PRO215A, PRO216A, PRO221A, PRO328A, PRO330A, PRO335B, PRO340A, PRO350A, PRO423A, PRO441B, PRO451A, PRO458B, PRO462B, PRO465B, PRO467A, PRO489A, PRO54A, PRO638B, PRO648B, PRO661B, PRO667B, PRO69A, PRO767A, PRO771A, PRO792A, PRO901B, PRO915B, PRO919B, PRO947B, PRO952B, PRO967B, SER1056B, SER1097B, SER1109B, SER1113B, SER15A, SER202A, SER222A, SER23A, SER314A, SER321A, SER322A, SER327A, SER424A, SER429A, SER467B, SER469A, SER504A, SER634B, SER647B, SER652A, SER666B, SER731B, SER736A, SER740B, SER784A, SER785A, SER814A, SER816A, SER828A, SER876B, SER920B, SER984B, THR1016B, THR1020B, THR1044B, THR1059B, THR1060B, THR1095B, THR200A, THR201A, THR210A, THR218A, THR297A, THR324A, THR346A, THR348A, THR442A, THR451B, THR461B, THR514A, THR517A, THR563B, THR60A, THR641B, THR645A, THR64A, THR670B, THR731A, THR733B, THR741A, THR763A, THR765A, THR788A, THR793A, THR809A, THR813A, THR923B, THR970B, THR973B, THR978B, TRP1072B, TRP206A, TRP453B, TRP646B, TYR1062B, TYR1069B, TYR1073B, TYR1098B, TYR276A, TYR341B, TYR377A, TYR390A, TYR453A, TYR502A, TYR507A, TYR545A, TYR628B, TYR660B, TYR671B, TYR726A, TYR735B, TYR761A, TYR772A, TYR791B, TYR818A, TYR949B, TYR987B, VAL1000B, VAL1012B, VAL1063B, VAL1081B, VAL1094B, VAL1096B, VAL1122B, VAL211A, VAL214A, VAL24A, VAL273A, VAL318A, VAL325A, VAL339A, VAL378A, VAL416A, VAL417A, VAL466A, VAL470B, VAL482A, VAL527A, VAL562B, VAL629B, VAL639A, VAL651A, VAL727A, VAL729B, VAL752A, VAL766B, VAL807A, VAL811A, VAL84A, VAL890B
• A-C: ALA113C, ALA128A, ALA240C, ALA299A, ALA317C, ALA343C, ALA345C, ALA346C, ALA357C, ALA358C, ALA359C, ALA472A, ALA474A, ALA476A, ALA55C, ALA65C, ALA69C, ALA74C, ALA75C, ALA826A, ALA832A, ALA849A, ALA861A, ARG124A, ARG130A, ARG131A, ARG203A, ARG239C, ARG290C, ARG301A, ARG308A, ARG310A, ARG311C, ARG322C, ARG327C, ARG331C, ARG344C, ARG360C, ARG427A, ARG45C, ARG490A, ARG690A, ARG812A, ARG821A, ARG822A, ARG831A, ARG839A, ARG870A, ARG874A, ASN312A, ASN339C, ASN34C, ASN372C, ASN38C, ASN454A, ASN5A, ASN825A, ASN869A, ASP112C, ASP198A, ASP254C, ASP278A, ASP307C, ASP309C, ASP318C, ASP31C, ASP356C, ASP362C, ASP46C, ASP49C, ASP53C, ASP559A, ASP808A, ASP829A, ASP835A, ASP852A, ASP853A, ASP867A, GLN243C, GLN300A, GLN304C, GLN328C, GLN606A, GLN76C, GLN815A, GLN820A, GLN847A, GLN84C, GLU109C, GLU134A, GLU291C, GLU306A, GLU30C, GLU337C, GLU348C, GLU364C, GLU365C, GLU371C, GLU387C, GLU40C, GLU471A, GLU475A, GLU478A, GLU47C, GLU58C, GLU618A, GLU61C, GLU68C, GLU80C, GLU833A, GLU844A, GLU873A, GLU92A, GLY103C, GLY12A, GLY196A, GLY304A, GLY305C, GLY307A, GLY311A, GLY315A, GLY324C, GLY330C, GLY333C, GLY336C, GLY361C, GLY368C, GLY376C, GLY382C, GLY384C, GLY492A, GLY62C, GLY67C, GLY689A, GLY71C, GLY79C, GLY817A, GLY82C, GLY836A, GLY843A, GLY851A, GLY854A, GLY85A, GLY863A, GLY877A, GLY8A, HIS312C, HIS332C, HIS353C, HIS377C, HIS426A, HIS83A, HIS862A, HIS89A, ILE108C, ILE13A, ILE241C, ILE281A, ILE28C, ILE294C, ILE297C, ILE313C, ILE329C, ILE36C, ILE373C, ILE374C, ILE375C, ILE379C, ILE428A, ILE479A, ILE487A, ILE495A, ILE51C, ILE56C, ILE64C, ILE687A, ILE6A, ILE70C, ILE72C, ILE824A, ILE846A, ILE871A, ILE9A, LEU102C, LEU104C, LEU107C, LEU14A, LEU195A, LEU24C, LEU298A, LEU301C, LEU302A, LEU306C, LEU313A, LEU314C, LEU315C, LEU32C, LEU342C, LEU354C, LEU355C, LEU35C, LEU381C, LEU388C, LEU425A, LEU54C, LEU63C, LEU692A, LEU823A, LEU827A, LEU830A, LEU841A, LYS10A, LYS114C, LYS122A, LYS123A, LYS244C, LYS27C, LYS303A, LYS305A, LYS316A, LYS338C, LYS33C, LYS352C, LYS367C, LYS380C, LYS39C, LYS50C, LYS57C, LYS617A, LYS7A, LYS864A, LYS879A, LYS88A, MET121C, MET207A, MET310C, MET320C, MET385C, MET819A, MET858A, PHE11A, PHE277A, PHE309A, PHE347C, PHE366C, PHE52C, PHE856A, PHE86A, PHE872A, PHE93A, PRO105C, PRO199A, PRO25C, PRO378C, PRO423A, PRO451A, PRO452A, PRO489A, PRO608A, PRO66C, PRO686A, PRO688A, PRO81C, PRO857A, SER127A, SER202A, SER314A, SER340C, SER37C, SER424A, SER429A, SER60C, SER77C, SER814A, SER816A, SER828A, SER840A, SER860A, THR119C, THR200A, THR201A, THR321C, THR323C, THR335C, THR350C, THR383C, THR44C, THR488A, THR691A, THR813A, THR837A, THR83C, THR865A, TRP125A, TRP614A, TRP878A, TYR197A, TYR491A, TYR59C, TYR818A, TYR834A, TYR842A, TYR850A, TYR859A, VAL111C, VAL192A, VAL242C, VAL29C, VAL308C, VAL316C, VAL319C, VAL325C, VAL334C, VAL341C, VAL349C, VAL351C, VAL363C, VAL369C, VAL370C, VAL386C, VAL41C, VAL43C, VAL73C, VAL78C, VAL838A, VAL845A, VAL848A, VAL84A, VAL855A, VAL866A, VAL868A, VAL875A, VAL876A, VAL87A
• A-D: ARG211D, ARG543A, ARG647A, ASN26D, ASP720A, GLN523A, GLU208D, GLU223D, GLU23D, GLU519A, GLU520A, GLU649A, LEU22D, PRO21D, SER220D, SER221D, TYR166D, TYR212D
• A-E: ALA472A, ARG12E, ARG352A, ASN16E, ASN5A, ASP63E, GLU471A, GLU475A, GLY62E, GLY64E, LEU59E, PHE61E, PRO15E, PRO403A, SER469A, VAL60E
• A-F: LYS4A, SER3F
• A-G: ALA538A, ALA541A, ARG20G, ARG543A, ARG573A, ARG63G, ARG647A, ARG91G, ASN108G, ASN25G, ASN47G, ASN577A, ASN590A, ASN68G, ASN723A, ASN87G, ASN88G, ASN90G, ASP41G, ASP44G, ASP579A, ASP583A, ASP69G, ASP70G, ASP720A, ASP83G, CYS575A, CYS580A, CYS72G, GLN550A, GLN642A, GLU110G, GLU536A, GLU544A, GLU578A, GLU595A, GLU80G, GLY21G, GLY535A, GLY548A, GLY591A, GLY596A, GLY73G, GLY75G, GLY877A, GLY89G, HIS116G, HIS30G, HIS563A, HIS582A, HIS74G, ILE115G, ILE28G, ILE42G, ILE43G, ILE46G, ILE539A, ILE592A, ILE77G, ILE93G, ILE95G, LEU113G, LEU23G, LEU26G, LEU508A, LEU515A, LEU534A, LEU540A, LEU593A, LEU594A, LEU64G, LEU81G, LYS109G, LYS114G, LYS24G, LYS512A, LYS549A, LYS558A, LYS589A, LYS82G, LYS879A, PHE112G, PHE49G, PHE71G, PHE722A, PRO537A, PRO542A, PRO572A, PRO581A, PRO721A, SER107G, SER22G, SER27G, SER45G, SER553A, SER584A, SER84G, SER85G, SER86G, THR510A, THR513A, THR514A, THR547A, THR67G, THR79G, TRP878A, TYR507A, TYR545A, TYR546A, TYR585A, TYR66G, TYR76G, TYR92G, VAL511A, VAL551A, VAL568A, VAL586A, VAL587A, VAL597A, VAL78G, VAL876A
• A-H: ALA120A, ALA849A, ARG124A, ARG38H, ARG46H, ARG67H, ARG79H, ARG839A, ASP835A, ASP852A, ASP853A, GLN41H, GLN70H, GLN847A, GLU34H, GLU40H, GLU74H, GLU833A, GLU844A, GLY36H, GLY73H, GLY843A, GLY851A, GLY854A, GLY863A, HIS862A, ILE121A, ILE31H, ILE37H, ILE82H, ILE846A, LEU32H, LEU35H, LEU42H, LEU71H, LYS122A, LYS123A, LYS68H, LYS864A, PRO126A, PRO39H, PRO43H, SER69H, SER77H, THR837A, TRP125A, TRP44H, TYR72H, TYR78H, TYR80H, TYR842A, TYR850A, VAL75H, VAL76H, VAL838A, VAL845A, VAL848A, VAL855A
• A-K: ALA33K, ALA38K, ALA40K, ALA44K, ALA472A, ALA474A, ALA476A, ALA47K, ALA49K, ALA65K, ALA832A, ALA849A, ARG29K, ARG34K, ARG352A, ARG39K, ARG427A, ARG434A, ARG79K, ARG80K, ARG81K, ARG831A, ARG839A, ASN16K, ASN357A, ASN485A, ASN54K, ASN55K, ASN84K, ASP12K, ASP413A, ASP415A, ASP52K, ASP60K, ASP835A, ASP852A, ASP853A, GLN42K, GLN847A, GLU17K, GLU31K, GLU351A, GLU470A, GLU471A, GLU475A, GLU478A, GLU622A, GLU66K, GLU68K, GLU833A, GLY404A, GLY414A, GLY46K, GLY836A, GLY851A, GLY854A, ILE32K, ILE353A, ILE358A, ILE36K, ILE428A, ILE473A, ILE479A, ILE486A, ILE487A, ILE53K, ILE56K, ILE62K, ILE64K, ILE78K, ILE88K, LEU13K, LEU27K, LEU361A, LEU41K, LEU43K, LEU481A, LEU50K, LEU82K, LEU90K, LYS360A, LYS477A, LYS484A, LYS70K, LYS864A, LYS86K, MET45K, MET480A, MET858A, PHE15K, PHE19K, PHE69K, PHE856A, PRO350A, PRO355A, PRO403A, PRO489A, PRO48K, PRO83K, SER37K, SER469A, SER63K, THR28K, THR354A, THR59K, THR837A, TRP23K, TRP356A, TYR30K, TYR834A, TYR850A, TYR859A, VAL20K, VAL35K, VAL406A, VAL416A, VAL61K, VAL838A, VAL845A, VAL848A, VAL855A
• A-L: ALA29L, ALA41L, ALA521A, ALA528A, ARG33L, ARG436A, ARG444A, ARG633A, ARG637A, ASN11L, ASN26L, ASN331A, ASN630A, ASP329A, ASP51L, ASP529A, ASP533A, ASP60L, GLN45L, GLN522A, GLN523A, GLU14L, GLU336A, GLU519A, GLU520A, GLU640A, GLU9L, GLY30L, GLY338A, GLY440A, GLY526A, GLY535A, HIS22L, HIS47L, ILE332A, ILE524A, ILE532A, ILE54L, ILE57L, LEU13L, LEU32L, LEU438A, LEU441A, LEU49L, LEU525A, LEU534A, LEU58L, LYS34L, LYS439A, LYS518A, LYS52L, LYS531A, LYS56L, LYS7L, PHE40L, PRO328A, PRO330A, PRO46L, PRO48L, SER10L, SER327A, SER39L, SER42L, SER8L, THR31L, THR442A, THR50L, THR517A, TRP372A, TYR12L, TYR43L, TYR44L, TYR546A, VAL38L, VAL437A, VAL527A, VAL530A
• A-Q: ALA120A, ALA128A, ALA129A, ARG116A, ARG130A, ARG66Q, ASN119A, ASN71Q, ASP62Q, ASP70Q, ASP74Q, GLU110A, GLU112A, GLU63Q, GLU69Q, GLU76Q, ILE111A, ILE117A, ILE121A, LEU132A, LEU67Q, LYS113A, LYS122A, LYS65Q, LYS73Q, LYS77Q, PHE68Q, PRO126A, SER115A, TRP125A, TYR114A, TYR118A, TYR135A, TYR72Q, TYR75Q
• A-V: ARG667A, ASP713A, GLU660A, ILE714A, LEU102V, LEU98V, LYS717A, PHE99V, PRO572A, SER97V, THR710A, TYR718A
• A-Y: ASN674A, GLU14Y, GLU15Y, GLU683A, GLU685A, LYS678A, SER11Y, TYR12Y
• B-C: ALA1045B, ALA1099B, ALA161C, ALA217C, ALA218C, ALA343C, ALA345C, ALA346C, ALA357C, ALA358C, ALA359C, ALA69C, ALA74C, ALA75C, ARG1036B, ARG1051B, ARG1115B, ARG223C, ASN185B, ASN253B, ASN372C, ASP1037B, ASP1054B, ASP159C, ASP356C, CYS1038B, GLN261B, GLN76C, GLU1033B, GLU1035B, GLU1106B, GLU1119B, GLU254B, GLU260B, GLU364C, GLU365C, GLU371C, GLU68C, GLY1041B, GLY1043B, GLY211B, GLY361C, GLY368C, GLY376C, GLY382C, GLY384C, GLY67C, GLY71C, HIS353C, HIS377C, ILE1040B, ILE1104B, ILE1111B, ILE1112B, ILE1117B, ILE158C, ILE160C, ILE251B, ILE373C, ILE374C, ILE375C, ILE379C, ILE70C, ILE72C, LEU1039B, LEU1047B, LEU1048B, LEU1052B, LEU1053B, LEU1103B, LEU1107B, LEU1116B, LEU219C, LEU255B, LEU259B, LEU342C, LEU354C, LEU355C, LEU381C, LYS1049B, LYS1101B, LYS221C, LYS380C, MET1034B, MET1046B, MET1110B, MET385C, PHE1031B, PHE1042B, PHE1100B, PHE220C, PHE256B, PHE347C, PHE366C, PRO1114B, PRO257B, PRO378C, SER1097B, SER1113B, SER157C, SER258B, SER263B, THR1044B, THR1095B, THR156C, THR212B, THR383C, TYR329B, VAL1094B, VAL1096B, VAL1122B, VAL341C, VAL349C, VAL351C, VAL363C, VAL369C, VAL370C, VAL386C, VAL73C
• B-D: ALA154D, ALA162D, ALA180D, ALA202D, ALA27D, ALA31D, ALA32D, ALA59D, ALA63D, ARG12D, ARG165D, ARG211D, ARG29D, ARG30D, ARG61D, ARG745B, ARG750B, ARG754B, ARG868B, ARG870B, ARG873B, ARG977B, ARG985B, ASN26D, ASN49D, ASN50D, ASN744B, ASP55D, ASP851B, ASP899B, ASP968B, ASP975B, CYS183D, CYS203D, CYS206D, CYS209D, GLN137D, GLN688B, GLN897B, GLN980B, GLU152D, GLU185D, GLU207D, GLU208D, GLU229D, GLU23D, GLU56D, GLU749B, GLU804B, GLU806B, GLU971B, GLY150D, GLY186D, GLY751B, GLY906B, GLY964B, GLY976B, GLY979B, HIS153D, HIS60D, HIS699B, ILE130D, ILE157D, ILE163D, ILE219D, ILE227D, ILE57D, ILE849B, ILE874B, ILE895B, ILE960B, ILE982B, ILE986B, LEU161D, LEU201D, LEU205D, LEU210D, LEU22D, LEU34D, LEU53D, LEU58D, LEU62D, LEU64D, LEU697B, LEU698B, LEU852B, LEU872B, LEU961B, LEU966B, LYS151D, LYS155D, LYS905B, LYS962B, LYS981B, LYS983B, MET33D, MET752B, MET900B, PHE156D, PHE24D, PHE46D, PHE758B, PRO158D, PRO168D, PRO184D, PRO52D, PRO896B, PRO901B, PRO967B, SER160D, SER221D, SER51D, SER746B, SER747B, SER755B, SER984B, THR181D, THR204D, THR756B, THR903B, THR970B, THR973B, THR978B, TYR166D, TYR167D, TYR212D, TYR226D, TYR35D, TYR54D, TYR683B, TYR687B, TYR700B, TYR902B, TYR963B, TYR965B, TYR974B, VAL159D, VAL164D, VAL182D, VAL233D, VAL25D, VAL748B, VAL850B, VAL898B, VAL904B, VAL907B, VAL908B, VAL972B
• B-E: ALA1045B, ALA65E, ARG1121B, ARG12E, ASN1090B, ASP1065B, ASP1120B, ASP63E, GLN1066B, GLN33E, GLY1043B, GLY62E, ILE10E, LEU1047B, LYS1049B, LYS40E, MET1046B, MET58E, PHE61E, SER1089B, THR1044B, TYR67E, VAL1122B, VAL11E, VAL60E
• B-F: ARG1121B, ASP1120B, SER3F, TYR5F, VAL1122B, VAL4F
• B-G: ASN25G, LYS983B
• B-K: ALA1045B, ALA33K, ALA38K, ARG29K, ARG34K, GLY1041B, GLY1043B, ILE1040B, LEU1039B, LEU1047B, LEU41K, MET1046B, PHE1042B, SER37K, THR1044B, TYR30K
• B-L: ARG33L, ARG745B, ARG977B, ASN26L, ASP21L, ASP51L, ASP899B, ASP975B, GLN45L, GLN980B, GLY734B, GLY892B, GLY976B, GLY979B, HIS22L, HIS47L, ILE877B, ILE895B, LEU49L, LEU894B, MET893B, PHE732B, PRO46L, PRO48L, PRO896B, SER876B, THR23L, THR50L, THR733B, THR978B, TYR43L, TYR44L, TYR735B, VAL898B
• B-N: ALA15N, ALA684B, ALA685B, ALA721B, ALA725B, ALA728B, ALA936B, ALA937B, ARG42N, ARG46N, ARG47N, ARG64N, ARG690B, ARG6N, ARG703B, ARG719B, ARG750B, ARG754B, ARG868B, ASN30N, ASN686B, ASN718B, ASN723B, ASN724B, ASN744B, ASN941B, ASP139B, ASP147B, ASP36N, ASP54N, ASP851B, ASP910B, CYS10N, CYS44N, CYS45N, CYS7N, GLN688B, GLN702B, GLN897B, GLU143B, GLU146B, GLU58N, GLU749B, GLU804B, GLU971B, GLY11N, GLY145B, GLY32N, GLY681B, GLY715B, GLY722B, GLY751B, GLY906B, GLY933B, GLY940B, GLY989B, HIS52N, HIS61N, HIS699B, ILE142B, ILE144B, ILE14N, ILE3N, ILE53N, ILE55N, ILE56N, ILE5N, ILE60N, ILE726B, ILE942B, LEU138B, LEU141B, LEU35N, LEU49N, LEU50N, LEU682B, LEU689B, LEU697B, LEU698B, LEU705B, LEU711B, LEU727B, LEU852B, LEU854B, LEU938B, LYS149B, LYS33N, LYS41N, LYS905B, LYS934B, MET1N, MET2N, MET48N, MET752B, MET86B, MET900B, PHE21N, PHE8N, PHE988B, PRO148B, PRO31N, PRO4N, PRO701B, PRO704B, PRO720B, PRO803B, PRO909B, SER12N, SER51N, SER57N, SER746B, SER747B, SER802B, SER939B, THR63N, THR717B, THR903B, THR9N, TYR43N, TYR62N, TYR683B, TYR687B, TYR700B, TYR716B, TYR753B, TYR935B, TYR963B, TYR965B, TYR992B, VAL25N, VAL34N, VAL40N, VAL59N, VAL748B, VAL853B, VAL904B, VAL907B, VAL908B, VAL911B, VAL990B, VAL991B
• B-P: ALA47P, ALA859B, ALA88B, ARG25P, ARG38P, ARG5P, ARG690B, ARG750B, ARG754B, ARG793B, ARG81B, ARG870B, ARG89B, ARG91B, ASN798B, ASN862B, ASN92B, ASP139B, ASP77B, ASP797B, ASP851B, CYS6P, GLN17P, GLN688B, GLU143B, GLU146B, GLU749B, GLU75B, GLU796B, GLU804B, GLU806B, GLU82B, GLU857B, GLU87B, GLY145B, GLY23P, GLY30P, GLY799B, GLY79B, GLY7P, GLY861B, ILE142B, ILE144B, ILE33P, ILE34P, ILE44P, ILE48P, ILE776B, ILE814B, ILE83B, ILE849B, ILE855B, ILE874B, LEU141B, LEU18P, LEU689B, LEU794B, LEU795B, LEU852B, LEU854B, LEU864B, LEU872B, LEU90B, LEU93B, LYS11P, LYS140B, LYS32P, LYS39P, LYS43P, LYS46P, LYS863B, LYS866B, LYS8P, MET36P, MET86B, PHE13P, PHE35P, PRO40P, PRO803B, SER76B, SER802B, SER84B, THR41P, THR691B, THR856B, THR858B, TRP10P, TYR136B, TYR31P, TYR4P, VAL20P, VAL24P, VAL37P, VAL45P, VAL748B, VAL800B, VAL801B, VAL805B, VAL807B, VAL850B, VAL853B, VAL865B, VAL867B
• C-E: ALA65E, ARG391C, ARG395C, ASN23E, GLU17E, GLU387C, GLU55E, GLU56E, GLY19E, GLY382C, GLY384C, GLY57E, GLY62E, GLY64E, HIS68E, ILE13E, ILE25E, ILE379C, ILE393C, LEU22E, LEU381C, LEU388C, LEU394C, LEU59E, LYS20E, LYS380C, MET385C, MET390C, MET58E, PHE18E, PHE61E, PRO14E, PRO15E, PRO21E, PRO378C, PRO392C, SER54E, THR383C, THR389C, THR53E, THR66E, TYR67E, VAL386C, VAL60E
• C-H: ALA270C, ALA288C, ALA289C, ALA317C, ALA47H, ALA52H, ARG12H, ARG278C, ARG290C, ARG295C, ARG311C, ARG322C, ARG327C, ARG46H, ARG64H, ARG67H, ARG79H, ASP10H, ASP268C, ASP309C, ASP318C, ASP31C, ASP49H, GLN26C, GLN41H, GLN70H, GLU273C, GLU279C, GLU281C, GLU282C, GLU287C, GLU291C, GLU296C, GLU30C, GLU40H, GLU61C, GLU74H, GLY285C, GLY324C, GLY73H, HIS14H, HIS20H, HIS312C, ILE13H, ILE269C, ILE277C, ILE280C, ILE286C, ILE28C, ILE292C, ILE293C, ILE294C, ILE45H, ILE63H, ILE65H, ILE66H, ILE82H, ILE9H, LEU16H, LEU258C, LEU262C, LEU314C, LEU32C, LEU42H, LEU71H, LYS19H, LYS271C, LYS27C, LYS299C, LYS338C, LYS367C, LYS68H, MET310C, MET320C, PHE284C, PRO11H, PRO18H, PRO25C, PRO39H, PRO43H, PRO50H, SER263C, SER298C, SER48H, SER69H, SER77H, THR123C, THR274C, THR321C, THR323C, TRP44H, TYR125C, TYR15H, TYR72H, TYR78H, TYR80H, VAL17H, VAL272C, VAL283C, VAL29C, VAL325C, VAL326C, VAL51H, VAL75H, VAL81H
• C-I: GLN11I, GLU135C, LYS136C
• C-K: ALA33K, ALA38K, ALA47K, ALA65C, ALA69C, ARG29K, ARG34K, ARG391C, ARG395C, ARG39K, ARG79K, ARG80K, ARG81K, ASN16K, GLN11K, GLN26C, GLN42K, GLU17K, GLU30C, GLU31K, GLU387C, GLU58C, GLU61C, GLU68C, GLU68K, GLY382C, GLY384C, GLY62C, GLY67C, GLY72K, HIS14K, ILE28C, ILE32K, ILE36K, ILE393C, ILE51K, ILE64C, ILE70C, ILE76K, ILE78K, ILE87K, LEU13K, LEU22K, LEU24C, LEU27K, LEU381C, LEU388C, LEU394C, LEU50K, LEU63C, LEU74K, LEU89K, LEU90K, LEU92K, LYS26K, LYS27C, MET385C, MET390C, PHE15K, PHE19K, PRO25C, PRO392C, PRO48K, PRO66C, PRO75K, SER21K, SER37K, SER60C, SER91K, THR28K, THR383C, THR389C, THR77K, TRP23K, TYR30K, TYR59C, VAL18K, VAL20K, VAL29C, VAL35K, VAL386C, VAL73C, VAL73K
• C-W: ASN674W, GLU14C, GLU15C, GLU683W, GLU685W, LYS678W, SER11C, TYR12C
• C-Y: ASN22Y, ASN34Y, ASN38Y, ASP133C, ASP247C, GLU135C, HIS132C, LEU42Y, LYS134C, LYS134Y, LYS18C, LYS18Y, LYS244C, LYS245C, LYS33Y, PRO25Y, SER21Y, SER37Y, TYR249C
• C-Z: GLU129C, LYS19Z
• D-G: ARG20G, ARG211D, ARG218D, ASN214D, ASN47G, LYS24G
• D-L: ALA245D, ALA27D, ALA29L, ALA31D, ALA32D, ALA72L, ALA80L, ARG240D, ARG251D, ARG29D, ARG30D, ARG33L, ARG77L, ASN26D, ASN26L, ASN4D, ASP14D, ASP21L, ASP224D, ASP51L, ASP67L, ASP85L, GLN45L, GLU18D, GLU20L, GLU239D, GLU23D, GLU244D, GLU254D, GLU255D, GLU257D, GLU262D, GLU2L, GLU74L, GLU80D, GLU86L, GLY19D, GLY19L, GLY246D, GLY25L, GLY30L, GLY89L, HIS22L, HIS82L, ILE13D, ILE17L, ILE241D, ILE249D, ILE250D, ILE253D, ILE264D, ILE28D, ILE28L, ILE3D, ILE3L, ILE53L, ILE57L, ILE5L, ILE73L, ILE84L, ILE87L, LEU13L, LEU15D, LEU15L, LEU228D, LEU22D, LEU230D, LEU242D, LEU243D, LEU24L, LEU256D, LEU260D, LEU27L, LEU32L, LEU34D, LEU5D, LEU69L, LEU6D, LEU70L, LEU90L, LYS151D, LYS247D, LYS252D, LYS258D, LYS259D, LYS34L, LYS4L, LYS66L, LYS71L, LYS88L, LYS8D, MET1L, MET33D, MET79L, PHE17D, PHE24D, PRO21D, PRO238D, PRO48L, PRO65L, SER248D, SER2D, SER81L, SER8L, THR23L, THR31L, THR75L, THR91L, TYR20D, TYR35D, TYR43L, TYR83L, VAL16D, VAL25D, VAL261D, VAL263D, VAL55L, VAL76L, VAL78L
• D-N: ALA102D, ALA135D, ALA154D, ALA15N, ALA162D, ALA63D, ARG12D, ARG42N, ARG61D, ARG64N, ARG6N, ASN104D, ASN136D, ASN49D, ASN50D, ASP127D, ASP16N, ASP54N, CYS10N, CYS44N, CYS45N, CYS7N, GLN137D, GLN19N, GLU105D, GLU229D, GLU231D, GLU48D, GLU58N, GLY11N, GLY126D, GLY134D, GLY234D, HIS153D, HIS52N, HIS60D, HIS61N, HIS7D, ILE124D, ILE128D, ILE130D, ILE14N, ILE157D, ILE163D, ILE3N, ILE56N, ILE57D, ILE5N, ILE60N, ILE65D, LEU109D, LEU132D, LEU133D, LEU13N, LEU161D, LEU236D, LEU53D, LEU58D, LEU62D, LEU64D, LYS107D, LYS11D, LYS138D, LYS155D, LYS17N, LYS41N, MET108D, MET1N, MET2N, MET33D, MET39D, PHE156D, PHE67D, PHE8N, PRO106D, PRO123D, PRO129D, PRO158D, PRO20N, PRO4N, PRO52D, PRO66D, SER111D, SER125D, SER12N, SER160D, SER232D, SER235D, SER40D, SER51D, SER57N, THR63N, THR9N, TRP18N, TYR110D, TYR54D, TYR62N, VAL131D, VAL159D, VAL233D, VAL38D, VAL59N
• D-P: ALA135D, ALA143D, ALA47P, ALA59D, ALA63D, ARG144D, ARG146D, ARG38P, ARG61D, ASN136D, ASN49D, ASN50D, ASP42D, ASP43D, ASP55D, GLN137D, GLU142D, GLU152D, GLU48D, GLU56D, HIS153D, HIS60D, ILE139D, ILE41D, ILE42P, ILE44P, ILE47D, ILE48P, ILE57D, LEU141D, LEU145D, LEU58D, LEU62D, LEU64D, LYS155D, LYS39P, LYS43P, LYS46P, LYS8P, PHE13P, PHE156D, PHE46D, PRO40P, SER140D, SER40D, SER51D, THR41P, TYR45D, TYR54D, VAL37P, VAL44D, VAL45P
• E-F: ALA144E, ALA17F, ALA47E, ALA70F, ALA73F, ALA7E, ARG143E, ARG145E, ARG31E, ARG36F, ARG84F, ARG8E, ASN100E, ASN32F, ASN42F, ASN50E, ASN92F, ASP105E, ASP23F, ASP39F, ASP41E, ASP67F, ASP73E, ASP81F, ASP90F, CYS76F, GLN166E, GLN35E, GLN35F, GLN53F, GLN82E, GLN91E, GLU36E, GLU45F, GLU66F, GLU69E, GLU71E, GLU82F, GLU83E, GLU86E, GLU88E, GLU8F, GLU9F, GLY102E, GLY106E, GLY28F, GLY87E, HIS10F, ILE10E, ILE12F, ILE147E, ILE25F, ILE48E, ILE5E, ILE6F, ILE75E, ILE75F, ILE78F, ILE86F, ILE88F, LEU101E, LEU169E, LEU20F, LEU21F, LEU27E, LEU30E, LEU33F, LEU34F, LEU39E, LEU41F, LEU42E, LEU44E, LEU46E, LEU49E, LEU4E, LEU72F, LEU87F, LEU90E, LYS141E, LYS18F, LYS19F, LYS26F, LYS37E, LYS3E, LYS40E, LYS46F, LYS6E, MET104E, MET1E, MET74E, MET89F, PHE72E, PRO103E, PRO13F, PRO167E, PRO77F, PRO80F, SER15F, SER22F, SER27F, SER29F, SER30F, SER31F, SER3F, SER43F, SER74F, SER85F, SER91F, SER9E, THR163E, THR37F, THR76E, THR79F, TYR11F, TYR14F, TYR168E, TYR2E, TYR34E, TYR38F, TYR40F, TYR5F, TYR67E, TYR77E, VAL11E, VAL142E, VAL146E, VAL16F, VAL24F, VAL44F, VAL45E, VAL4F, VAL68F, VAL70E, VAL71F, VAL78E, VAL7F, VAL80E, VAL81E, VAL83F, VAL84E, VAL85E, VAL99E
• E-K: ALA33K, ALA38K, ALA40K, ALA44K, ALA47K, ALA49K, ALA65E, ARG12E, ARG34K, ARG39K, ARG79K, ASN16E, ASP63E, GLN42K, GLU17E, GLU56E, GLY19E, GLY46K, GLY57E, GLY62E, GLY64E, ILE13E, ILE76K, LEU41K, LEU43K, LEU50K, LEU59E, LEU89K, LYS20E, MET45K, MET58E, PHE18E, PHE61E, PRO14E, PRO15E, PRO48K, PRO75K, SER37K, THR66E, THR77K, TYR30K, TYR67E, VAL35K, VAL60E
• G-V: ASN16G, ASN16V, ASN37G, ASN37V, GLN51G, GLN51V, GLU19G, GLU19V, HIS30G, ILE15G, ILE15V, ILE18G, ILE18V, LYS52G, LYS52V, SER17G, SER17V, SER32G, SER32V
• G-W: ARG667W, ASP713W, GLU660W, ILE714W, LEU102G, LEU98G, LYS717W, PHE99G, PRO572W, SER97G, THR710W, TYR718W
• H-K: ALA28H, ARG64H, ASN16K, ASN84K, ASP12K, GLN11K, GLU17K, GLU21H, GLU27H, GLU34H, GLU74H, GLY36H, GLY85K, HIS14K, ILE31H, ILE37H, ILE65H, ILE66H, LEU13K, LEU23H, LEU32H, LEU35H, LEU82K, LYS30H, LYS33H, LYS86K, PHE15K, PHE19K, PRO83K, SER77H, TYR72H, TYR78H, VAL18K, VAL20K, VAL75H, VAL76H
• H-Q: ALA28H, ALA47H, ALA57H, ALA64Q, ARG38H, ARG66Q, ASN47Q, ASN53Q, ASN56Q, ASN71Q, ASP26H, ASP52Q, ASP61H, ASP62Q, ASP70Q, ASP74Q, GLN41H, GLU27H, GLU40H, GLU49Q, GLU63Q, GLY57Q, GLY60H, ILE25H, ILE37H, ILE50Q, ILE59Q, ILE62H, ILE82H, LEU23H, LEU32H, LEU42H, LEU44Q, LEU54Q, LEU55Q, LEU67Q, LYS30H, LYS33H, LYS58H, LYS58Q, PHE68Q, PRO39H, PRO59H, SER24H, SER60Q, THR48Q, TRP51Q, TYR29H, TYR80H, VAL22H, VAL61Q, VAL81H
• H-Y: GLU129Y, LYS19H
• I-R: ALA1045R, ALA33I, ALA38I, ARG29I, ARG34I, GLY1041R, GLY1043R, ILE1040R, LEU1039R, LEU1047R, LEU41I, MET1046R, PHE1042R, SER37I, THR1044R, TYR30I
• I-T: ALA33I, ALA38I, ALA40I, ALA44I, ALA47I, ALA49I, ALA65T, ARG12T, ARG34I, ARG39I, ARG79I, ARG81I, ASN16T, ASP63T, GLN42I, GLU17T, GLU56T, GLY19T, GLY46I, GLY57T, GLY62T, GLY64T, ILE13T, ILE76I, LEU41I, LEU43I, LEU50I, LEU59T, LEU89I, LYS20T, MET45I, MET58T, PHE18T, PHE61T, PRO14T, PRO15T, PRO48I, PRO75I, SER37I, THR66T, THR77I, TYR30I, VAL35I, VAL60T
• I-W: ALA33I, ALA38I, ALA40I, ALA44I, ALA472W, ALA474W, ALA476W, ALA47I, ALA49I, ALA65I, ALA832W, ALA849W, ARG29I, ARG34I, ARG352W, ARG39I, ARG427W, ARG434W, ARG79I, ARG80I, ARG81I, ARG831W, ARG839W, ASN16I, ASN357W, ASN485W, ASN54I, ASN55I, ASN84I, ASP12I, ASP413W, ASP415W, ASP52I, ASP60I, ASP835W, ASP852W, ASP853W, GLN42I, GLN847W, GLU17I, GLU31I, GLU351W, GLU470W, GLU471W, GLU475W, GLU478W, GLU622W, GLU66I, GLU68I, GLU833W, GLY404W, GLY414W, GLY46I, GLY836W, GLY851W, GLY854W, ILE32I, ILE353W, ILE358W, ILE36I, ILE428W, ILE473W, ILE479W, ILE486W, ILE487W, ILE53I, ILE56I, ILE62I, ILE64I, ILE78I, ILE88I, LEU13I, LEU27I, LEU361W, LEU41I, LEU43I, LEU481W, LEU50I, LEU82I, LEU90I, LYS360W, LYS477W, LYS484W, LYS70I, LYS864W, LYS86I, MET45I, MET480W, MET858W, PHE15I, PHE19I, PHE69I, PHE856W, PRO350W, PRO355W, PRO403W, PRO489W, PRO48I, PRO83I, SER37I, SER469W, SER63I, THR28I, THR354W, THR59I, THR837W, TRP23I, TRP356W, TYR30I, TYR834W, TYR850W, TYR859W, VAL20I, VAL35I, VAL406W, VAL416W, VAL61I, VAL838W, VAL845W, VAL848W, VAL855W
• I-Y: ARG29I, ARG79I, ARG81I, ASN16I, GLN11I, GLN26Y, GLU17I, GLU30Y, GLU31I, GLU387Y, GLU58Y, GLU61Y, GLU68Y, GLY62Y, HIS14I, ILE28Y, LEU13I, LEU22I, LEU24Y, LYS26I, LYS27Y, PHE15I, PHE19I, PRO25Y, SER21I, SER60Y, THR389Y, THR77I, TRP23I, TYR30I, TYR59Y, VAL18I, VAL29Y
• I-Z: ARG64Z, ASP12I, GLU17I, GLU27Z, GLU34Z, GLU74Z, HIS14I, LYS30Z
• J-W: ALA120W, ALA128W, ALA129W, ARG116W, ARG130W, ARG66J, ASN119W, ASN71J, ASP62J, ASP70J, ASP74J, GLU112W, GLU63J, GLU69J, GLU76J, ILE111W, ILE117W, ILE121W, LEU132W, LEU67J, LYS113W, LYS122W, LYS65J, LYS73J, LYS77J, PHE68J, PRO126W, SER115W, TRP125W, TYR114W, TYR118W, TYR135W, TYR72J, TYR75J
• J-Z: ARG38Z, ARG66J, ASP62J, ASP70J, GLU40Z, GLU63J, LYS33Z
• M-R: ARG33M, ARG745R, ARG977R, ASN26M, ASP21M, ASP51M, ASP899R, ASP975R, GLN45M, GLN980R, GLY734R, GLY892R, GLY976R, GLY979R, HIS22M, HIS47M, ILE877R, ILE895R, LEU49M, LEU894R, MET893R, PHE732R, PRO46M, PRO48M, PRO896R, SER876R, THR23M, THR50M, THR733R, THR978R, TYR43M, TYR44M, TYR735R, VAL898R
• M-S: ALA245S, ALA27S, ALA29M, ALA31S, ALA32S, ALA72M, ALA80M, ARG240S, ARG251S, ARG29S, ARG30S, ARG33M, ARG77M, ASN26M, ASN26S, ASN4S, ASP14S, ASP21M, ASP224S, ASP51M, ASP67M, ASP85M, GLN45M, GLU18S, GLU20M, GLU239S, GLU23S, GLU244S, GLU254S, GLU255S, GLU257S, GLU262S, GLU2M, GLU74M, GLU80S, GLU86M, GLY19M, GLY19S, GLY246S, GLY25M, GLY30M, GLY89M, HIS22M, HIS82M, ILE13S, ILE17M, ILE241S, ILE249S, ILE250S, ILE253S, ILE264S, ILE28M, ILE28S, ILE3M, ILE3S, ILE53M, ILE57M, ILE5M, ILE73M, ILE84M, ILE87M, LEU13M, LEU15M, LEU15S, LEU228S, LEU22S, LEU230S, LEU242S, LEU243S, LEU24M, LEU256S, LEU260S, LEU27M, LEU32M, LEU34S, LEU5S, LEU69M, LEU6S, LEU70M, LEU90M, LYS151S, LYS247S, LYS252S, LYS258S, LYS259S, LYS34M, LYS4M, LYS66M, LYS71M, LYS88M, LYS8S, MET1M, MET33S, MET79M, PHE17S, PHE24S, PRO21S, PRO238S, PRO48M, PRO65M, SER248S, SER2S, SER81M, SER8M, THR23M, THR31M, THR75M, THR91M, TYR20S, TYR35S, TYR43M, TYR83M, VAL16S, VAL25S, VAL261S, VAL263S, VAL55M, VAL76M, VAL78M
• M-W: ALA29M, ALA41M, ALA521W, ALA528W, ARG33M, ARG436W, ARG444W, ARG633W, ARG637W, ASN11M, ASN26M, ASN331W, ASN630W, ASP329W, ASP51M, ASP529W, ASP533W, ASP60M, GLN45M, GLN522W, GLN523W, GLU14M, GLU336W, GLU519W, GLU520W, GLU536W, GLU640W, GLU9M, GLY30M, GLY338W, GLY440W, GLY526W, GLY535W, HIS22M, HIS47M, ILE332W, ILE524W, ILE532W, ILE54M, ILE57M, LEU13M, LEU32M, LEU438W, LEU441W, LEU49M, LEU525W, LEU534W, LEU58M, LYS34M, LYS439W, LYS518W, LYS52M, LYS531W, LYS56M, LYS7M, PHE40M, PRO328W, PRO330W, PRO46M, PRO48M, SER10M, SER327W, SER39M, SER42M, SER8M, THR31M, THR442W, THR50M, THR517W, TRP372W, TYR12M, TYR43M, TYR44M, TYR546W, VAL38M, VAL437W, VAL527W, VAL530W, VAL55M
• N-P: ARG38P, ARG64N, ASP15P, CYS9P, GLY7P, ILE33P, LYS39P, LYS8P, MET36P, PHE13P, PHE35P, THR63N, TRP10P, TYR62N, VAL37P
• O-R: ALA15O, ALA684R, ALA685R, ALA721R, ALA725R, ALA728R, ALA936R, ALA937R, ALA969R, ARG42O, ARG46O, ARG47O, ARG64O, ARG690R, ARG6O, ARG703R, ARG719R, ARG750R, ARG754R, ARG868R, ASN30O, ASN686R, ASN718R, ASN723R, ASN724R, ASN744R, ASN941R, ASP139R, ASP147R, ASP36O, ASP54O, ASP851R, ASP910R, CYS10O, CYS44O, CYS45O, CYS7O, GLN688R, GLN702R, GLN897R, GLU143R, GLU146R, GLU58O, GLU749R, GLU804R, GLU971R, GLY11O, GLY145R, GLY32O, GLY681R, GLY715R, GLY722R, GLY751R, GLY906R, GLY933R, GLY940R, GLY989R, HIS52O, HIS61O, HIS699R, ILE142R, ILE144R, ILE14O, ILE3O, ILE53O, ILE55O, ILE56O, ILE5O, ILE60O, ILE726R, ILE942R, ILE986R, LEU138R, LEU141R, LEU35O, LEU49O, LEU50O, LEU682R, LEU689R, LEU697R, LEU698R, LEU705R, LEU711R, LEU727R, LEU852R, LEU854R, LEU938R, LYS149R, LYS33O, LYS41O, LYS905R, LYS934R, MET1O, MET2O, MET48O, MET752R, MET86R, MET900R, PHE21O, PHE8O, PHE988R, PRO148R, PRO31O, PRO4O, PRO701R, PRO704R, PRO720R, PRO803R, PRO909R, SER12O, SER51O, SER57O, SER746R, SER747R, SER802R, SER939R, THR63O, THR717R, THR903R, THR970R, THR9O, TYR43O, TYR62O, TYR683R, TYR687R, TYR700R, TYR716R, TYR753R, TYR935R, TYR963R, TYR965R, TYR987R, TYR992R, VAL25O, VAL34O, VAL40O, VAL59O, VAL748R, VAL853R, VAL904R, VAL907R, VAL908R, VAL911R, VAL990R, VAL991R
• O-S: ALA102S, ALA135S, ALA154S, ALA15O, ALA162S, ALA63S, ARG12S, ARG42O, ARG61S, ARG64O, ARG6O, ASN104S, ASN136S, ASN49S, ASN50S, ASP127S, ASP16O, ASP54O, CYS10O, CYS44O, CYS45O, CYS7O, GLN137S, GLN19O, GLU105S, GLU229S, GLU231S, GLU48S, GLU58O, GLY11O, GLY126S, GLY134S, GLY234S, HIS153S, HIS52O, HIS60S, HIS61O, HIS7S, ILE124S, ILE128S, ILE130S, ILE14O, ILE157S, ILE163S, ILE3O, ILE55O, ILE56O, ILE57S, ILE5O, ILE60O, ILE65S, LEU109S, LEU132S, LEU133S, LEU13O, LEU161S, LEU236S, LEU53S, LEU58S, LEU62S, LEU64S, LYS107S, LYS11S, LYS138S, LYS155S, LYS17O, LYS41O, MET108S, MET1O, MET2O, MET33S, MET39S, PHE156S, PHE67S, PHE8O, PRO106S, PRO123S, PRO129S, PRO158S, PRO20O, PRO4O, PRO52S, PRO66S, SER111S, SER125S, SER12O, SER160S, SER232S, SER235S, SER40S, SER51S, SER57O, THR63O, THR9O, TRP18O, TYR110S, TYR54S, TYR62O, VAL131S, VAL159S, VAL233S, VAL38S, VAL59O
• O-X: ARG38X, ARG64O, ASP15X, CYS9X, GLY7X, LYS39X, LYS8X, MET36X, PHE13X, PHE35X, THR63O, TRP10X, TYR62O, VAL37X
• R-S: ALA154S, ALA162S, ALA180S, ALA202S, ALA27S, ALA31S, ALA32S, ALA59S, ALA63S, ARG12S, ARG165S, ARG211S, ARG29S, ARG30S, ARG61S, ARG745R, ARG750R, ARG754R, ARG868R, ARG870R, ARG873R, ARG977R, ARG985R, ASN26S, ASN49S, ASN50S, ASN744R, ASP55S, ASP851R, ASP871R, ASP899R, ASP968R, ASP975R, CYS183S, CYS203S, CYS206S, CYS209S, GLN137S, GLN688R, GLN897R, GLN980R, GLU152S, GLU185S, GLU207S, GLU208S, GLU229S, GLU23S, GLU56S, GLU749R, GLU804R, GLU806R, GLU971R, GLY150S, GLY186S, GLY751R, GLY906R, GLY964R, GLY976R, GLY979R, HIS153S, HIS60S, HIS699R, ILE130S, ILE157S, ILE163S, ILE219S, ILE227S, ILE57S, ILE849R, ILE874R, ILE895R, ILE960R, ILE982R, ILE986R, LEU161S, LEU201S, LEU205S, LEU210S, LEU228S, LEU22S, LEU34S, LEU53S, LEU58S, LEU62S, LEU64S, LEU697R, LEU698R, LEU852R, LEU872R, LEU961R, LEU966R, LYS151S, LYS155S, LYS905R, LYS962R, LYS981R, LYS983R, MET33S, MET752R, MET900R, PHE156S, PHE24S, PHE46S, PHE758R, PRO158S, PRO168S, PRO184S, PRO52S, PRO896R, PRO901R, PRO967R, SER160S, SER221S, SER51S, SER746R, SER747R, SER755R, SER984R, THR181S, THR204S, THR756R, THR903R, THR970R, THR973R, THR978R, TYR166S, TYR167S, TYR212S, TYR226S, TYR35S, TYR54S, TYR683R, TYR687R, TYR700R, TYR902R, TYR963R, TYR965R, TYR974R, VAL159S, VAL164S, VAL182S, VAL233S, VAL25S, VAL748R, VAL850R, VAL898R, VAL904R, VAL907R, VAL908R, VAL972R
• R-T: ALA1045R, ALA65T, ARG1121R, ARG12T, ASN1090R, ASP1065R, ASP1120R, ASP63T, GLN1066R, GLN33T, GLY1043R, GLY62T, ILE10T, LEU1047R, LYS1049R, LYS40T, MET1046R, MET58T, PHE61T, SER1089R, THR1044R, TYR67T, VAL1122R, VAL11T, VAL60T
• R-U: ARG1121R, ASP1120R, SER3U, TYR5U, VAL1122R, VAL4U
• R-V: ASN25V, LYS983R
• R-W: ALA1001R, ALA1006R, ALA1008R, ALA1045R, ALA1099R, ALA299W, ALA342R, ALA344W, ALA432W, ALA445R, ALA455W, ALA472W, ALA474R, ALA474W, ALA476W, ALA498W, ALA499W, ALA621R, ALA627R, ALA630R, ALA649R, ALA655R, ALA725W, ALA728R, ALA729W, ALA733W, ALA744W, ALA799W, ALA800W, ALA810W, ALA917R, ALA932R, ALA969R, ARG1007R, ARG1009R, ARG1017R, ARG1023R, ARG1025R, ARG1030R, ARG1036R, ARG1051R, ARG1058R, ARG1115R, ARG1121R, ARG13R, ARG20W, ARG220W, ARG293W, ARG301W, ARG308W, ARG310W, ARG317W, ARG323W, ARG333R, ARG345W, ARG385W, ARG389W, ARG421W, ARG427W, ARG436W, ARG438R, ARG444W, ARG446R, ARG455R, ARG48W, ARG580R, ARG633W, ARG637W, ARG647W, ARG668R, ARG734W, ARG745R, ARG753W, ARG759W, ARG764W, ARG779W, ARG784R, ARG787W, ARG803W, ARG821W, ARG836R, ARG921R, ARG977R, ARG985R, ASN1055R, ASN1076R, ASN1078R, ASN1090R, ASN312W, ASN331W, ASN343R, ASN376W, ASN420W, ASN442R, ASN454W, ASN463W, ASN466R, ASN472R, ASN485W, ASN5W, ASN605W, ASN626R, ASN63W, ASN664R, ASN669R, ASN67W, ASN723W, ASN736R, ASN739W, ASN825W, ASN914R, ASP1002R, ASP1037R, ASP1050R, ASP1054R, ASP1057R, ASP1065R, ASP1074R, ASP1120R, ASP17W, ASP278W, ASP319W, ASP329W, ASP336R, ASP337R, ASP339R, ASP387W, ASP447R, ASP456W, ASP458W, ASP460W, ASP501W, ASP564R, ASP620R, ASP635R, ASP650W, ASP655W, ASP739R, ASP773W, ASP808W, ASP829W, ASP879R, ASP968R, ASP975R, CYS1038R, CYS1067R, CYS1082R, CYS450W, CYS457R, CYS58W, CYS61W, CYS68W, GLN1013R, GLN1018R, GLN1066R, GLN1105R, GLN300W, GLN422W, GLN440R, GLN452R, GLN468W, GLN500W, GLN523W, GLN642W, GLN665R, GLN742W, GLN750W, GLN815W, GLN820W, GLN887R, GLN926R, GLN957R, GLN980R, GLU1021R, GLU1026R, GLU1033R, GLU1035R, GLU1106R, GLU1119R, GLU18W, GLU306W, GLU334R, GLU341W, GLU408W, GLU444R, GLU460R, GLU461W, GLU463R, GLU470W, GLU471W, GLU475W, GLU519W, GLU520W, GLU53W, GLU568R, GLU622R, GLU623R, GLU624R, GLU625R, GLU632R, GLU639R, GLU640W, GLU644R, GLU649W, GLU662R, GLU738R, GLU794W, GLU804W, GLU929R, GLU954R, GLU971R, GLY1010R, GLY1022R, GLY1027R, GLY1028R, GLY1032R, GLY1041R, GLY1043R, GLY1068R, GLY1071R, GLY1086R, GLY12W, GLY307W, GLY311W, GLY315W, GLY439R, GLY440W, GLY450R, GLY454R, GLY459W, GLY464R, GLY468R, GLY497W, GLY505W, GLY62W, GLY643W, GLY654W, GLY66W, GLY70W, GLY732W, GLY734R, GLY735W, GLY73W, GLY760W, GLY788R, GLY789W, GLY801W, GLY802W, GLY805W, GLY817W, GLY845R, GLY85W, GLY878R, GLY889R, GLY892R, GLY8W, GLY925R, GLY930R, GLY979R, HIS1005R, HIS1085R, HIS340R, HIS426W, HIS449R, HIS465W, HIS570R, HIS640R, HIS642R, HIS663R, HIS71W, HIS74W, HIS768W, HIS798W, HIS83W, HIS844R, HIS916R, HIS998R, ILE1004R, ILE1014R, ILE1040R, ILE1061R, ILE1070R, ILE1084R, ILE1104R, ILE1111R, ILE1112R, ILE1117R, ILE13W, ILE19W, ILE208W, ILE217W, ILE219W, ILE223W, ILE326W, ILE332W, ILE342W, ILE343W, ILE379W, ILE386W, ILE428W, ILE473W, ILE479W, ILE503W, ILE524W, ILE52W, ILE561R, ILE566R, ILE636W, ILE650R, ILE6W, ILE730R, ILE740W, ILE741R, ILE742R, ILE757W, ILE824W, ILE877R, ILE891R, ILE895R, ILE912R, ILE927R, ILE931R, ILE953R, ILE960R, ILE982R, ILE986R, ILE9W, LEU1015R, LEU1029R, LEU1039R, LEU1047R, LEU1048R, LEU1052R, LEU1053R, LEU1091R, LEU1102R, LEU1103R, LEU1107R, LEU1116R, LEU1118R, LEU14W, LEU209W, LEU212W, LEU235W, LEU239W, LEU298W, LEU302W, LEU313W, LEU347W, LEU418W, LEU425W, LEU438W, LEU441W, LEU445W, LEU447W, LEU448R, LEU448W, LEU464W, LEU469R, LEU481W, LEU49W, LEU508W, LEU515W, LEU516W, LEU582R, LEU619R, LEU631R, LEU641W, LEU643R, LEU648W, LEU651R, LEU65W, LEU738W, LEU747W, LEU766W, LEU790W, LEU795W, LEU806W, LEU827W, LEU830W, LEU841W, LEU894R, LEU913R, LEU918R, LEU924R, LEU996R, LYS1003R, LYS1049R, LYS1075R, LYS1077R, LYS10W, LYS1101R, LYS21W, LYS303W, LYS305W, LYS316W, LYS324R, LYS338R, LYS392W, LYS439W, LYS471R, LYS477W, LYS4W, LYS658W, LYS758W, LYS770W, LYS787R, LYS789R, LYS791W, LYS7W, LYS880R, LYS888R, LYS950R, LYS981R, LYS983R, MET1034R, MET1046R, MET1108R, MET1110R, MET207W, MET224W, MET22W, MET430W, MET431W, MET456R, MET462W, MET480W, MET646W, MET675R, MET728W, MET737R, MET743W, MET762W, MET847R, MET858W, MET893R, MET922R, MET928R, MET999R, PHE1031R, PHE1042R, PHE1092R, PHE1100R, PHE11W, PHE277W, PHE309W, PHE320W, PHE419W, PHE443R, PHE443W, PHE457W, PHE459R, PHE565R, PHE632W, PHE638W, PHE644W, PHE724W, PHE72W, PHE732R, PHE769W, PHE786W, PHE796W, PHE797W, PHE856W, PHE86W, PHE881R, PHE948R, PHE988R, PRO1011R, PRO1019R, PRO1083R, PRO1093R, PRO1114R, PRO16W, PRO213W, PRO215W, PRO216W, PRO221W, PRO328W, PRO330W, PRO335R, PRO340W, PRO350W, PRO423W, PRO441R, PRO451W, PRO458R, PRO462R, PRO465R, PRO467W, PRO489W, PRO54W, PRO59W, PRO638R, PRO648R, PRO661R, PRO667R, PRO69W, PRO767W, PRO771W, PRO792W, PRO901R, PRO915R, PRO919R, PRO947R, PRO952R, PRO967R, SER1056R, SER1097R, SER1109R, SER1113R, SER15W, SER202W, SER222W, SER23W, SER314W, SER321W, SER322W, SER327W, SER424W, SER429W, SER467R, SER469W, SER504W, SER634R, SER647R, SER652W, SER666R, SER731R, SER736W, SER740R, SER784W, SER785W, SER814W, SER816W, SER828W, SER876R, SER920R, SER984R, THR1016R, THR1020R, THR1044R, THR1059R, THR1060R, THR1095R, THR200W, THR201W, THR210W, THR218W, THR297W, THR324W, THR346W, THR348W, THR442W, THR451R, THR461R, THR514W, THR517W, THR563R, THR60W, THR641R, THR645W, THR64W, THR670R, THR731W, THR733R, THR741W, THR763W, THR765W, THR788W, THR793W, THR809W, THR813W, THR838R, THR923R, THR970R, THR973R, THR978R, TRP1072R, TRP206W, TRP453R, TRP646R, TYR1062R, TYR1069R, TYR1073R, TYR1098R, TYR276W, TYR341R, TYR377W, TYR390W, TYR453W, TYR502W, TYR507W, TYR545W, TYR628R, TYR660R, TYR671R, TYR726W, TYR735R, TYR761W, TYR772W, TYR791R, TYR818W, TYR949R, TYR987R, VAL1000R, VAL1012R, VAL1063R, VAL1081R, VAL1094R, VAL1096R, VAL1122R, VAL211W, VAL214W, VAL24W, VAL273W, VAL318W, VAL325W, VAL339W, VAL378W, VAL416W, VAL417W, VAL466W, VAL470R, VAL482W, VAL527W, VAL562R, VAL629R, VAL639W, VAL651W, VAL727W, VAL729R, VAL752W, VAL766R, VAL807W, VAL811W, VAL84W, VAL890R
• R-X: ALA47X, ALA859R, ALA88R, ARG25X, ARG38X, ARG5X, ARG690R, ARG750R, ARG754R, ARG793R, ARG81R, ARG870R, ARG89R, ARG91R, ASN798R, ASN862R, ASN92R, ASP139R, ASP77R, ASP797R, ASP851R, CYS6X, GLN17X, GLN688R, GLU143R, GLU146R, GLU749R, GLU75R, GLU796R, GLU804R, GLU806R, GLU82R, GLU857R, GLU87R, GLY145R, GLY23X, GLY30X, GLY799R, GLY79R, GLY7X, GLY861R, ILE142R, ILE144R, ILE33X, ILE34X, ILE44X, ILE48X, ILE776R, ILE814R, ILE83R, ILE849R, ILE855R, ILE874R, LEU141R, LEU18X, LEU689R, LEU794R, LEU795R, LEU852R, LEU854R, LEU864R, LEU872R, LEU90R, LEU93R, LYS11X, LYS140R, LYS32X, LYS39X, LYS43X, LYS46X, LYS863R, LYS866R, LYS8X, MET36X, MET86R, PHE13X, PHE35X, PRO40X, PRO803R, SER76R, SER802R, SER84R, THR41X, THR691R, THR856R, THR858R, TRP10X, TYR136R, TYR31X, TYR4X, VAL20X, VAL24X, VAL37X, VAL45X, VAL748R, VAL800R, VAL801R, VAL805R, VAL807R, VAL850R, VAL853R, VAL865R, VAL867R
• R-Y: ASP159Y, GLU254R
• S-V: ARG20V, ARG211S, ARG218S, ASN214S, ASN47V, LYS24V
• S-W: ARG211S, ARG543W, ARG647W, ASN26S, ASP720W, GLN523W, GLU223S, GLU23S, GLU519W, GLU520W, GLU649W, LEU22S, PRO21S, SER220S, SER221S, TYR166S, TYR212S
• S-X: ALA135S, ALA143S, ALA47X, ALA59S, ALA63S, ARG144S, ARG146S, ARG38X, ARG61S, ASN136S, ASN49S, ASN50S, ASP42S, ASP43S, ASP55S, GLN137S, GLU142S, GLU152S, GLU48S, GLU56S, HIS153S, HIS60S, ILE139S, ILE41S, ILE42X, ILE44X, ILE47S, ILE48X, ILE57S, LEU141S, LEU145S, LEU58S, LEU62S, LEU64S, LYS155S, LYS39X, LYS43X, LYS46X, LYS8X, LYS95S, PHE13X, PHE156S, PHE46S, PRO40X, SER140S, SER40S, SER51S, THR41X, TYR45S, TYR54S, VAL37X, VAL44S, VAL45X
• T-U: ALA144T, ALA17U, ALA47T, ALA70U, ALA73U, ALA7T, ARG143T, ARG145T, ARG31T, ARG36U, ARG84U, ARG8T, ASN100T, ASN32U, ASN42U, ASN50T, ASN92U, ASP105T, ASP23U, ASP39U, ASP41T, ASP67U, ASP73T, ASP81U, ASP90U, CYS76U, GLN166T, GLN35T, GLN35U, GLN53U, GLN82T, GLN91T, GLU36T, GLU45U, GLU66U, GLU69T, GLU71T, GLU82U, GLU83T, GLU86T, GLU88T, GLU8U, GLU9U, GLY102T, GLY106T, GLY28U, GLY87T, HIS10U, ILE10T, ILE12U, ILE147T, ILE25U, ILE48T, ILE5T, ILE6U, ILE75T, ILE75U, ILE78U, ILE86U, ILE88U, LEU101T, LEU169T, LEU20U, LEU21U, LEU27T, LEU30T, LEU33U, LEU34U, LEU39T, LEU41U, LEU42T, LEU44T, LEU46T, LEU49T, LEU4T, LEU72U, LEU87U, LEU90T, LYS141T, LYS18U, LYS19U, LYS26U, LYS37T, LYS3T, LYS40T, LYS46U, LYS6T, MET104T, MET1T, MET74T, MET89U, PHE72T, PRO103T, PRO13U, PRO167T, PRO77U, PRO80U, SER15U, SER22U, SER27U, SER29U, SER30U, SER31U, SER3U, SER43U, SER74U, SER85U, SER91U, SER9T, THR163T, THR37U, THR76T, THR79U, TYR11U, TYR14U, TYR168T, TYR2T, TYR34T, TYR38U, TYR40U, TYR5U, TYR77T, VAL11T, VAL142T, VAL146T, VAL16U, VAL24U, VAL44U, VAL45T, VAL4U, VAL68U, VAL70T, VAL71U, VAL78T, VAL7U, VAL80T, VAL81T, VAL83U, VAL84T, VAL85T, VAL99T
• T-W: ARG12T, ARG352W, ASN16T, ASN5W, ASP63T, GLU471W, GLU475W, GLY62T, GLY64T, LEU59T, PHE61T, PRO15T, PRO403W, SER469W, VAL60T
• T-Y: ARG391Y, ARG395Y, GLU55T, GLU56T, GLY57T, MET390Y
• U-W: LYS4W, SER3U
• V-W: ALA538W, ALA541W, ARG20V, ARG543W, ARG573W, ARG63V, ARG647W, ARG91V, ASN108V, ASN25V, ASN47V, ASN577W, ASN590W, ASN68V, ASN723W, ASN87V, ASN88V, ASN90V, ASP41V, ASP44V, ASP579W, ASP583W, ASP69V, ASP70V, ASP720W, ASP83V, CYS575W, CYS580W, CYS72V, GLN550W, GLN642W, GLU110V, GLU536W, GLU544W, GLU578W, GLU595W, GLU80V, GLY21V, GLY535W, GLY548W, GLY591W, GLY596W, GLY73V, GLY75V, GLY877W, GLY89V, HIS116V, HIS30V, HIS563W, HIS582W, HIS74V, ILE115V, ILE28V, ILE42V, ILE43V, ILE46V, ILE539W, ILE592W, ILE77V, ILE93V, ILE95V, LEU113V, LEU23V, LEU26V, LEU508W, LEU515W, LEU534W, LEU540W, LEU593W, LEU594W, LEU64V, LEU81V, LYS109V, LYS114V, LYS24V, LYS512W, LYS549W, LYS558W, LYS589W, LYS82V, LYS879W, PHE112V, PHE49V, PHE71V, PHE722W, PRO537W, PRO542W, PRO572W, PRO581W, PRO721W, SER107V, SER22V, SER27V, SER45V, SER553W, SER584W, SER84V, SER85V, SER86V, THR510W, THR513W, THR514W, THR547W, THR67V, THR79V, TRP878W, TYR507W, TYR545W, TYR546W, TYR585W, TYR66V, TYR76V, TYR92V, VAL511W, VAL551W, VAL568W, VAL586W, VAL587W, VAL597W, VAL78V, VAL876W
• W-Y: ALA346Y, ALA359Y, ALA55Y, ALA832W, ALA861W, ARG124W, ARG130W, ARG311Y, ARG322Y, ARG331Y, ARG360Y, ARG427W, ARG45Y, ARG490W, ARG690W, ARG812W, ARG821W, ARG822W, ARG831W, ARG870W, ARG874W, ASN34Y, ASN38Y, ASN869W, ASP112Y, ASP198W, ASP254Y, ASP307Y, ASP309Y, ASP31Y, ASP356Y, ASP362Y, ASP46Y, ASP49Y, ASP53Y, ASP559W, ASP829W, ASP852W, ASP853W, ASP867W, GLN76Y, GLN84Y, GLU30Y, GLU337Y, GLU348Y, GLU364Y, GLU365Y, GLU371Y, GLU40Y, GLU47Y, GLU58Y, GLU618W, GLU61Y, GLU68Y, GLU80Y, GLU844W, GLU873W, GLY62Y, GLY67Y, GLY854W, GLY863W, GLY877W, HIS312Y, HIS426W, HIS862W, HIS89W, ILE28Y, ILE36Y, ILE51Y, ILE56Y, ILE871W, ILE9W, LEU24Y, LEU32Y, LEU35Y, LEU54Y, LYS27Y, LYS338Y, LYS33Y, LYS352Y, LYS380Y, LYS39Y, LYS50Y, LYS57Y, LYS617W, LYS7W, LYS864W, LYS879W, LYS88W, PHE52Y, PHE856W, PHE872W, PRO25Y, PRO489W, SER202W, SER37Y, SER60Y, SER860W, THR44Y, THR865W, TRP614W, TRP878W, TYR59Y, TYR859W, VAL29Y, VAL369Y, VAL41Y, VAL43Y, VAL855W, VAL866W, VAL868W, VAL875W, VAL876W
• W-Z: ARG67Z, ASP835W, ASP852W, GLN41Z, GLU34Z, GLU40Z, LYS122W, VAL845W
• Y-Z: ARG290Y, ARG322Y, ARG46Z, ARG67Z, ARG79Z, ASP268Y, ASP49Z, GLU281Y, GLU287Y, GLU291Y, GLU30Y, GLU74Z, HIS14Z, HIS20Z, LEU42Z, LYS271Y, LYS68Z, PRO43Z, THR321Y, THR323Y