2XSO

crystal structure of p4 variant of biphenyl dioxygenase from burkholderia xenovorans lb400

• Total interactions analyzed: 276
• Total true interactions: 66
• Strongest Interaction:
  • Chains: E-G
  • Int. Res.: 135
  • Norm. En. per Res.: -6.0011
• Hub Node: D(9)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-107.2576	-108.2204	-487.573	-703.051	164	21	10	19634	4	56	60
A-E	0.0	-10.4595	-9.1065	-19.566	21	0	0	648	0	7	10
A-F	-22.9809	1.174	-201.972	-223.7789	69	4	9	7190	0	22	21
A-H	0.0	-4.5749	-4.7318	-9.3068	15	0	0	426	0	7	3
B-E	0.0	17.2019	-48.1615	-30.9596	35	3	0	2137	0	31	29
B-F	-20.9861	-41.8837	-111.614	-174.4838	79	5	1	4938	7	47	43
C-D	-98.6522	-94.0341	-494.665	-687.3513	162	15	10	20065	5	58	59
C-E	-115.3075	-168.3477	-486.831	-770.4862	136	22	7	17671	11	62	42
C-F	-17.8898	7.8642	-65.2971	-75.3228	46	3	0	2548	6	14	14
C-G	-151.7724	-173.0369	-474.331	-799.1403	138	23	7	17659	10	63	42
C-K	0.0	-7.8085	-9.1907	-16.9993	21	0	0	595	0	7	10
C-L	0.0	22.3747	-48.1714	-25.7967	34	0	0	2187	0	31	29
C-O	-20.7741	-26.1104	-111.076	-157.9606	103	8	1	5488	3	38	36
D-F	-76.9076	-88.6019	-379.3	-544.8095	135	17	11	15057	10	40	39
D-G	-18.7266	4.9598	-61.232	-74.9988	45	4	0	2563	7	14	14
D-H	-63.464	-121.751	-384.878	-570.093	138	16	10	15345	12	39	41
D-K	-34.2919	-4.8908	-213.051	-252.2337	68	6	9	7443	2	20	20
D-L	-22.449	-31.5604	-117.024	-171.0335	80	3	1	4989	8	45	43
D-M	0.0	0.0	-13.5629	-13.5629	26	0	0	654	0	3	2
D-N	0.0	-8.4701	-36.1204	-44.5904	32	0	1	2012	1	14	14
D-S	-5.8998	-5.2138	-10.8295	-21.9431	18	0	0	600	0	7	4
D-U	0.0	0.0	-0.0067	-0.0067	2	0	0	3	0	2	1
E-F	-108.6107	-91.8863	-481.896	-682.393	165	22	10	19821	5	55	59
E-G	-149.3211	-169.6619	-491.165	-810.148	135	22	6	17714	10	63	42
E-H	-16.1143	4.571	-69.2374	-80.7807	46	7	0	2608	6	14	14
F-H	-75.0875	-106.821	-392.853	-574.7616	137	25	9	15244	14	38	40
F-K	0.0	-4.4873	-6.2968	-10.7841	17	0	0	501	0	7	5
G-H	-111.1564	-95.0233	-490.606	-696.7857	163	20	10	19930	6	56	58
G-S	0.0	-10.5889	-12.6051	-23.194	21	0	0	727	0	8	9
G-T	0.0	14.101	-39.1515	-25.0505	33	0	0	1950	0	31	28
H-S	-21.7942	4.9411	-210.315	-227.1681	71	8	9	7387	0	21	20
H-T	-6.838	-34.7262	-115.833	-157.3972	79	3	1	5275	6	47	45
H-U	0.0	0.0	-11.6529	-11.6529	23	0	0	662	0	3	2
H-V	-5.8524	-2.7503			10
I-J	-115.7467	-111.8709	-495.571	-723.1886	169	19	10	20202	4	58	60
I-O	-105.1687	-154.9945	-473.026	-733.1893	137	33	7	17937	8	63	41
I-P	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	0
J-O	-38.7877	9.313	-76.6981	-106.1728	44	6	0	2757	6	14	14
J-P	-73.4882	-90.7641	-437.784	-602.0364	132	30	9	16923	9	41	41
K-L	-103.1538	-115.8076	-497.106	-716.0674	163	17	10	19910	6	56	61
K-M	-123.7809	-169.1838	-505.471	-798.4357	134	18	6	18015	10	62	41
K-Q	-112.8235	-174.2353	-499.059	-786.1177	136	23	7	18006	11	62	45
K-R	-12.1843	-0.4679	-70.7276	-83.3797	47	10	0	2648	6	14	14
L-M	-13.9483	7.2955	-74.3963	-81.0491	45	3	0	2555	6	14	14
L-N	-86.458	-81.1924	-446.711	-614.3614	130	29	10	16624	12	40	40
L-R	-69.7639	-123.3212	-445.374	-638.4591	133	25	10	16751	11	40	43
M-N	-105.9908	-108.3665	-496.685	-711.0424	165	17	10	20234	5	58	61
M-Q	-147.8845	-163.2449	-495.78	-806.9094	139	21	7	17828	10	63	42
M-R	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
N-Q	-11.0175	8.1756	-69.0329	-71.8748	43	8	0	2582	5	14	14
N-R	-84.8822	-94.5084	-445.834	-625.2246	133	32	9	16899	11	39	41
N-U	0.0	0.0	-5.6974	-5.6974	11	0	1	414	0	9	11
O-P	-102.1935	-104.0268	-499.593	-705.8133	166	21	10	20174	6	57	59
Q-R	-111.0898	-104.1752	-486.203	-701.468	164	23	10	20026	6	56	58
S-T	-95.3788	-110.0584	-490.315	-695.7522	167	16	10	19879	6	56	60
S-U	-95.1032	-161.9186	-493.838	-750.8598	134	19	6	17527	8	58	36
S-W	-88.0242	-175.6375			32
S-X	-32.1089	4.9468			11
T-U	-21.8267	2.5435	-50.0817	-69.365	40	4	0	2021	0	10	10
T-V	-79.8294	-84.5642			24
T-X	-56.9004	-93.0579			18
U-V	-100.2263	-115.19			31
U-W	-90.4252	-161.2183			31
V-W	-9.4376	1.9318			9
V-X	-85.8993	-84.967			20
W-X	-91.1937	-108.1825			40

Interface residues

• A-B: ALA103B, ALA112A, ALA115A, ALA176B, ALA207A, ALA245A, ALA354A, ALA364A, ALA380A, ALA75A, ALA80B, ARG106A, ARG109A, ARG138B, ARG140B, ARG143B, ARG345A, ARG371A, ARG372A, ARG376A, ARG400A, ARG61B, ARG64B, ARG67B, ARG92B, ARG94B, ASN105B, ASN114A, ASN182B, ASN183B, ASN337A, ASN338A, ASN374A, ASN377A, ASN391A, ASN63B, ASP111A, ASP146B, ASP252A, ASP387A, ASP388A, ASP72A, ASP76B, ASP78B, ASP83B, ASP99B, CYS108A, CYS218A, GLN144B, GLN212A, GLN255A, GLN386A, GLN77B, GLU104B, GLU142B, GLU250A, GLU349A, GLU351A, GLU368A, GLU385A, GLU390A, GLU394A, GLU68B, GLU72B, GLU84B, GLU87B, GLY101B, GLY113A, GLY209A, GLY210A, GLY242A, GLY246A, GLY381A, GLY382A, GLY389A, GLY75B, GLY91B, HIS239A, HIS343A, HIS373A, HIS55B, HIS66A, HIS81B, ILE208A, ILE216A, ILE243A, ILE247A, ILE339A, ILE350A, ILE375A, ILE66B, ILE93B, LEU141B, LEU179B, LEU180B, LEU184B, LEU240A, LEU244A, LEU253A, LEU357A, LEU60B, LEU71B, LEU74A, LEU79B, LYS213A, LYS367A, LYS397A, LYS95B, MET186B, MET211A, MET251A, MET58B, MET65B, MET89B, PHE148B, PHE187B, PHE188B, PHE355A, PHE378A, PHE384A, PHE57B, PHE73A, PHE82B, PRO106B, PRO217A, PRO248A, PRO249A, PRO290A, PRO59B, PRO6B, SER110A, SER121A, SER177B, SER181B, SER185B, SER241A, SER254A, SER379A, SER74B, SER98B, THR178B, THR236A, THR237A, THR238A, THR356A, THR62B, THR85B, THR88B, THR97B, TRP102B, TRP214A, TRP353A, TRP392A, TYR370A, TYR56B, TYR77A, TYR90B, VAL100B, VAL215A, VAL352A, VAL358A, VAL383A, VAL393A, VAL96B
• A-E: ALA115E, ARG317A, ASN114E, ASP72E, GLN294A, GLU298A, GLU303A, GLU365A, GLU69E, GLY299A, GLY71E, ILE366A, LYS116E, LYS291A, LYS89E, PRO290A, PRO300A, PRO363A, PRO68E, THR297A, THR70E
• A-F: ALA234A, ALA256A, ALA286A, ARG153F, ARG61F, ARG67F, ASP252A, ASP76F, GLN255A, GLN257A, GLU13F, GLU151F, GLU250A, GLU68F, GLU70F, GLU72F, GLY235A, GLY246A, GLY282A, GLY289A, GLY69F, GLY75F, HIS233A, HIS239A, HIS55F, HIS7F, ILE172F, ILE243A, ILE247A, ILE258A, ILE66F, LEU173F, LEU240A, LEU244A, LEU253A, LEU285A, LEU60F, LEU71F, LYS10F, LYS120F, LYS261A, MET231A, MET251A, PHE12F, PHE57F, PHE8F, PHE9F, PRO248A, PRO249A, PRO259A, PRO281A, PRO290A, PRO59F, PRO6F, SER241A, SER254A, SER283A, SER74F, THR11F, THR171F, THR236A, THR237A, THR238A, THR260A, TRP14F, TYR232A, TYR277A, TYR433A, TYR73F
• A-H: ALA42H, ALA45H, ARG41H, ASP252A, ASP39H, GLN255A, GLN257A, GLN36H, GLU250A, GLU44H, HIS40H, LEU37H, MET251A, SER254A, TYR43H
• B-E: ALA123B, ALA168B, ALA364E, ARG157B, ARG158B, ARG371E, ARG372E, ASP126B, ASP160B, ASP51B, ASP53B, GLN294E, GLU365E, GLU368E, GLU369E, HIS55B, HIS86B, ILE366E, ILE375E, ILE54B, LEU156B, LEU50B, LYS169B, LYS291E, LYS367E, LYS52B, PRO125B, PRO249E, PRO290E, PRO363E, SER166B, THR124B, THR127B, THR85B, VAL155B
• B-F: ALA123F, ALA159B, ALA168F, ALA42B, ALA45B, ALA48B, ALA80F, ARG153F, ARG157F, ARG158B, ARG41B, ARG94B, ASN161B, ASN162B, ASP160B, ASP51B, ASP51F, ASP53B, ASP53F, ASP76F, ASP78F, ASP83F, ASP99B, GLN77F, GLU129F, GLU13F, GLU44B, GLU84F, GLU87B, GLU87F, GLY164B, GLY75F, HIS40B, HIS55F, HIS86B, HIS86F, ILE54B, ILE54F, ILE93B, LEU163B, LEU37B, LEU49B, LEU50B, LYS10F, LYS120F, LYS169F, LYS17F, LYS52B, LYS52F, MET89F, PHE12F, PHE47B, PHE47F, PHE57F, PHE9F, PRO107B, PRO125F, PRO15F, SER166F, SER16F, SER98B, THR122F, THR124F, THR127F, THR171F, THR85B, THR85F, THR88B, THR88F, THR97B, TRP102B, TRP14F, TRP46B, TYR43B, TYR90B, TYR90F, VAL100B, VAL155F, VAL96B
• C-D: ALA103D, ALA112C, ALA115C, ALA176D, ALA207C, ALA245C, ALA354C, ALA364C, ALA380C, ALA75C, ALA80D, ARG106C, ARG109C, ARG138D, ARG140D, ARG143D, ARG345C, ARG371C, ARG372C, ARG376C, ARG400C, ARG61D, ARG64D, ARG92D, ARG94D, ASN105D, ASN114C, ASN182D, ASN183D, ASN337C, ASN338C, ASN374C, ASN377C, ASN391C, ASN63D, ASP111C, ASP146D, ASP252C, ASP387C, ASP388C, ASP72C, ASP76D, ASP78D, ASP83D, ASP99D, CYS108C, CYS218C, GLN144D, GLN212C, GLN386C, GLN77D, GLU104D, GLU142D, GLU250C, GLU349C, GLU351C, GLU368C, GLU385C, GLU390C, GLU394C, GLU68D, GLU72D, GLU84D, GLU87D, GLY101D, GLY113C, GLY209C, GLY210C, GLY242C, GLY246C, GLY381C, GLY382C, GLY389C, GLY75D, GLY91D, HIS233C, HIS239C, HIS343C, HIS373C, HIS55D, HIS66C, HIS81D, ILE208C, ILE216C, ILE243C, ILE247C, ILE339C, ILE350C, ILE375C, ILE66D, ILE93D, LEU141D, LEU179D, LEU180D, LEU184D, LEU240C, LEU244C, LEU253C, LEU357C, LEU60D, LEU71D, LEU74C, LEU79D, LYS116C, LYS213C, LYS367C, LYS397C, LYS95D, MET186D, MET211C, MET251C, MET58D, MET65D, MET89D, PHE148D, PHE187D, PHE188D, PHE355C, PHE378C, PHE384C, PHE57D, PHE73C, PHE82D, PRO106D, PRO217C, PRO248C, PRO249C, PRO59D, SER110C, SER121C, SER177D, SER181D, SER185D, SER241C, SER379C, SER74D, SER98D, THR178D, THR236C, THR237C, THR238C, THR356C, THR62D, THR85D, THR88D, THR97D, TRP102D, TRP214C, TRP353C, TRP392C, TYR370C, TYR56D, TYR73D, TYR77C, TYR90D, VAL100D, VAL215C, VAL352C, VAL358C, VAL383C, VAL393C, VAL96D
• C-E: ALA126C, ALA142C, ALA163C, ALA223E, ALA234E, ALA404E, ALA411E, ALA434E, ALA438E, ARG101C, ARG103C, ARG106C, ARG109C, ARG345C, ARG400E, ARG417E, ARG439E, ARG52C, ARG56C, ASN135C, ASN175C, ASN391E, ASN410E, ASN98C, ASP154C, ASP177C, ASP230E, ASP387E, ASP388E, ASP81C, CYS100C, CYS108C, CYS120C, GLN162C, GLN226E, GLN396E, GLN407E, GLN412E, GLN43E, GLN99C, GLU139C, GLU141C, GLU157C, GLU225E, GLU349C, GLU351C, GLU390E, GLU394E, GLU435E, GLU47C, GLU49C, GLU51C, GLU80C, GLY104C, GLY124C, GLY159C, GLY235E, GLY33E, GLY346C, GLY389E, GLY398E, GLY401E, GLY414E, GLY55C, GLY79C, HIS102C, HIS123C, HIS233E, HIS239E, HIS343C, ILE107C, ILE258E, ILE395E, ILE39E, LEU133C, LEU161C, LEU240E, LEU34E, LEU35E, LEU399E, LEU409E, LEU415E, LEU48C, LEU50C, LEU97C, LYS140C, LYS221E, LYS261E, LYS32E, LYS397E, LYS403E, LYS405E, MET105C, MET231E, MET413E, MET78C, PHE138C, PHE143C, PHE153C, PHE222E, PHE54C, PRO137C, PRO160C, PRO259E, PRO344C, PRO37E, PRO408E, PRO82C, SER121C, SER229E, SER406E, THR119C, THR236E, THR237E, THR238E, THR260E, TRP125C, TRP158C, TRP176C, TRP353C, TRP392E, TYR122C, TYR232E, TYR277E, TYR402E, TYR40E, TYR431E, TYR433E, TYR442E, TYR46C, TYR77C, VAL136C, VAL178C, VAL393E, VAL432E, VAL83C
• C-F: ALA103F, ALA112C, ALA75C, ARG106C, ARG109C, ARG109F, ARG140F, ARG143F, ARG345C, ASN105F, ASN98C, ASP111C, ASP99F, CYS108C, CYS120C, GLU104F, GLU142F, GLU349C, GLU351C, GLU80C, GLY101F, GLY124C, GLY346C, HIS343C, ILE216C, ILE350C, LEU141F, LYS213C, MET105C, PRO106F, PRO107F, PRO217C, PRO344C, PRO82C, SER110C, SER121C, THR119C, THR76C, TRP102F, TRP214C, TRP353C, TYR122C, TYR77C, VAL100F, VAL215C, VAL352C
• C-G: ALA126G, ALA142G, ALA163G, ALA223C, ALA234C, ALA404C, ALA411C, ALA434C, ALA438C, ARG101G, ARG103G, ARG106G, ARG109G, ARG345G, ARG400C, ARG417C, ARG439C, ARG52G, ARG56G, ASN135G, ASN175G, ASN391C, ASN410C, ASN98G, ASP154G, ASP177G, ASP230C, ASP387C, ASP388C, ASP81G, CYS100G, CYS108G, CYS120G, GLN162G, GLN226C, GLN396C, GLN407C, GLN412C, GLN43C, GLN43G, GLN99G, GLU139G, GLU141G, GLU157G, GLU225C, GLU349G, GLU351G, GLU390C, GLU394C, GLU435C, GLU47G, GLU49G, GLU51G, GLU80G, GLY104G, GLY124G, GLY159G, GLY235C, GLY33C, GLY346G, GLY389C, GLY398C, GLY401C, GLY414C, GLY55G, GLY79G, HIS102G, HIS123G, HIS233C, HIS239C, HIS343G, ILE107G, ILE258C, ILE395C, ILE39C, LEU133G, LEU161G, LEU240C, LEU34C, LEU35C, LEU399C, LEU409C, LEU415C, LEU48G, LEU50G, LEU97G, LYS140G, LYS155G, LYS221C, LYS261C, LYS32C, LYS397C, LYS403C, LYS405C, MET105G, MET231C, MET413C, MET441C, MET78G, PHE138G, PHE143G, PHE153G, PHE222C, PHE54G, PRO137G, PRO160G, PRO259C, PRO37C, PRO408C, PRO82G, SER121G, SER229C, SER406C, THR119G, THR236C, THR237C, THR238C, THR260C, TRP125G, TRP158G, TRP176G, TRP353G, TRP392C, TYR122G, TYR232C, TYR277C, TYR402C, TYR40C, TYR431C, TYR433C, TYR442C, TYR46G, TYR77G, VAL136G, VAL178G, VAL393C, VAL432C, VAL83G
• C-K: ALA115C, ARG317K, ASN114C, ASP72C, GLN294K, GLU298K, GLU303K, GLU365K, GLU69C, GLY299K, GLY71C, ILE366K, LYS116C, LYS291K, LYS89C, LYS91C, PRO290K, PRO300K, PRO68C, THR297K, THR70C
• C-L: ALA123L, ALA168L, ALA364C, ARG157L, ARG158L, ARG371C, ARG372C, ASP126L, ASP160L, ASP51L, ASP53L, GLN294C, GLU365C, GLU368C, GLU369C, HIS55L, HIS86L, ILE366C, ILE375C, ILE54L, LEU156L, LEU50L, LYS169L, LYS291C, LYS367C, LYS52L, PRO125L, PRO249C, PRO290C, PRO363C, SER166L, THR124L, THR127L, VAL155L
• C-O: ALA130O, ALA156O, ALA163O, ALA180O, ALA268C, ALA268O, ALA455C, ALA455O, ARG164O, ARG191C, ARG191O, ARG25C, ARG266C, ARG308O, ARG417C, ARG439C, ARG447C, ASN428C, ASP128O, ASP177O, ASP182O, ASP189C, ASP189O, ASP195O, ASP199O, ASP29C, ASP424C, ASP90O, GLN162O, GLN179C, GLN179O, GLN307O, GLN30C, GLN412C, GLN419C, GLN88O, GLU184O, GLU31C, GLU451C, GLY131O, GLY188O, GLY26C, GLY310C, GLY310O, GLY313C, GLY33C, GLY416C, GLY421C, GLY427C, HIS311C, HIS311O, HIS422C, HIS443C, ILE129O, ILE93O, LEU161O, LEU183O, LEU309O, LEU34C, LEU415C, LEU457C, LYS132O, LYS169O, LYS32C, LYS458C, LYS458O, LYS89O, LYS91O, LYS94O, MET314C, MET446C, PHE425C, PHE96O, PRO160O, PRO181O, PRO192C, PRO192O, PRO202O, PRO423C, PRO426C, PRO459C, PRO459O, SER418C, SER453C, SER453O, SER92O, THR167O, THR185O, THR312C, THR312O, THR420C, THR456C, THR456O, TRP269C, TRP454C, TRP454O, TYR168O, VAL134O, VAL165O, VAL178O, VAL28C, VAL429C, VAL95O
• D-F: ALA133D, ALA133F, ALA149D, ALA176D, ALA18D, ALA19D, ALA35F, ALA42F, ALA45F, ARG109F, ARG111F, ARG138F, ARG140F, ARG143F, ARG152D, ARG152F, ARG153D, ARG33F, ARG41F, ARG61D, ARG64D, ARG67D, ARG94F, ASN105F, ASN116D, ASN116F, ASN131D, ASN139F, ASN161F, ASN162F, ASN25D, ASN25F, ASN63D, ASP146D, ASP160F, ASP175D, ASP39F, ASP99F, GLN144F, GLN24D, GLN24F, GLN29F, GLN36F, GLU104F, GLU13D, GLU142F, GLU151D, GLU22D, GLU22F, GLU26F, GLU28D, GLU28F, GLU34F, GLU44F, GLU68D, GLU72D, GLY101F, GLY150D, GLY164F, GLY20D, GLY20F, GLY69D, HIS112D, HIS112F, HIS40F, HIS7D, ILE118D, ILE135D, ILE135F, ILE147D, ILE147F, ILE172D, ILE66D, ILE93F, LEU113D, LEU113F, LEU136D, LEU136F, LEU141F, LEU163F, LEU173D, LEU174D, LEU179D, LEU180D, LEU21D, LEU21F, LEU23F, LEU37F, LYS10D, LYS17D, LYS95F, MET65D, PHE134D, PHE134F, PHE148D, PHE148F, PHE30F, PHE8D, PRO106F, PRO107F, PRO15D, PRO6D, SER108F, SER115D, SER115F, SER132D, SER16D, SER177D, SER181D, SER98F, THR110F, THR11D, THR178D, THR62D, THR97F, TRP102F, TRP14D, TYR137D, TYR137F, TYR31F, TYR32D, TYR32F, TYR43F, TYR73D, TYR90F, VAL100F, VAL114D, VAL114F, VAL117D, VAL117F, VAL119D, VAL130D, VAL145D, VAL145F, VAL96F
• D-G: ALA103D, ALA112G, ALA75G, ARG106G, ARG109D, ARG109G, ARG140D, ARG143D, ARG345G, ASN105D, ASN98G, ASP111G, ASP99D, CYS108G, CYS120G, GLU104D, GLU142D, GLU349G, GLU351G, GLU80G, GLY101D, GLY124G, HIS343G, ILE216G, ILE350G, LEU141D, LYS213G, MET105G, PRO106D, PRO107D, PRO217G, PRO344G, PRO82G, SER110G, SER121G, THR119G, THR76G, TRP102D, TRP214G, TRP353G, TYR122G, TYR77G, VAL100D, VAL215G, VAL352G
• D-H: ALA133H, ALA149H, ALA176H, ALA18H, ALA19H, ALA35D, ALA42D, ALA45D, ALA48D, ARG109D, ARG111D, ARG138D, ARG140D, ARG143D, ARG152D, ARG152H, ARG153H, ARG33D, ARG41D, ARG61H, ARG64H, ARG67H, ARG94D, ASN105D, ASN116D, ASN116H, ASN131H, ASN139D, ASN161D, ASN162D, ASN25D, ASN25H, ASN63H, ASP146H, ASP160D, ASP175H, ASP39D, ASP99D, GLN144D, GLN24D, GLN24H, GLN29D, GLN36D, GLU104D, GLU13H, GLU142D, GLU151H, GLU22D, GLU22H, GLU26D, GLU28D, GLU28H, GLU34D, GLU44D, GLU68H, GLU72H, GLY101D, GLY150H, GLY164D, GLY20D, GLY20H, GLY69H, HIS112D, HIS112H, HIS40D, HIS7H, ILE118H, ILE135D, ILE135H, ILE147D, ILE147H, ILE172H, ILE66H, ILE93D, LEU113D, LEU113H, LEU136D, LEU136H, LEU141D, LEU163D, LEU173H, LEU174H, LEU179H, LEU180H, LEU21D, LEU21H, LEU23D, LEU23H, LEU37D, LEU49D, LYS10H, LYS17H, LYS95D, MET65H, PHE12H, PHE134D, PHE134H, PHE148D, PHE148H, PHE30D, PHE8H, PRO106D, PRO107D, PRO15H, PRO6H, SER108D, SER115D, SER115H, SER132H, SER16H, SER177H, SER181H, SER98D, THR110D, THR11H, THR178H, THR62H, THR97D, TRP102D, TRP14H, TRP46D, TYR137D, TYR137H, TYR31D, TYR32D, TYR32H, TYR43D, TYR73H, TYR90D, VAL100D, VAL114D, VAL114H, VAL117D, VAL117H, VAL119H, VAL130H, VAL145D, VAL96D
• D-K: ALA234K, ALA256K, ALA286K, ARG153D, ARG61D, ARG67D, ASP252K, ASP76D, GLN255K, GLN257K, GLN294K, GLU13D, GLU151D, GLU250K, GLU280K, GLU68D, GLU70D, GLU72D, GLY235K, GLY246K, GLY282K, GLY69D, GLY75D, HIS233K, HIS239K, HIS7D, ILE172D, ILE243K, ILE247K, ILE258K, ILE66D, LEU173D, LEU240K, LEU244K, LEU253K, LEU285K, LEU60D, LEU71D, LYS10D, LYS261K, MET231K, MET251K, PHE12D, PHE384K, PHE57D, PHE8D, PHE9D, PRO248K, PRO249K, PRO259K, PRO281K, PRO290K, PRO59D, PRO6D, SER254K, SER283K, SER74D, THR11D, THR171D, THR236K, THR237K, THR238K, THR260K, TRP14D, TYR232K, TYR277K, TYR433K, TYR73D
• D-L: ALA123D, ALA159L, ALA168D, ALA42L, ALA45L, ALA48L, ALA80D, ARG153D, ARG157D, ARG158L, ARG41L, ARG94L, ASN161L, ASN162L, ASP160L, ASP51D, ASP51L, ASP53D, ASP53L, ASP76D, ASP78D, ASP83D, ASP99L, GLN77D, GLU121D, GLU129D, GLU13D, GLU44L, GLU84D, GLU87D, GLU87L, GLY164L, GLY75D, HIS40L, HIS55D, HIS86D, HIS86L, ILE54D, ILE54L, LEU163L, LEU37L, LEU49L, LEU50L, LYS10D, LYS120D, LYS169D, LYS17D, LYS52D, LYS52L, MET89D, PHE12D, PHE47D, PHE47L, PHE57D, PHE82D, PHE9D, PRO107L, PRO125D, PRO15D, SER166D, SER16D, SER98L, THR122D, THR124D, THR127D, THR171D, THR85D, THR85L, THR88D, THR88L, THR97L, TRP102L, TRP14D, TRP46L, TYR43L, TYR90D, TYR90L, VAL100L, VAL155D, VAL96L
• D-M: ALA115M, ALA117M, ALA126M, ASN135M, ASP128M, CYS120M, GLU141M, GLY124M, HIS123M, HIS7D, ILE129M, LYS116M, PHE118M, PHE12D, PHE138M, PHE9D, PRO137M, PRO15D, SER121M, THR119M, THR11D, TRP125M, TRP14D, TYR127M, VAL134M, VAL136M
• D-N: ALA123D, ALA159D, ALA18D, ARG157D, ARG158D, ARG67N, ASP126D, ASP160D, GLU121D, GLU13N, GLU68N, GLU70N, GLY69N, ILE66N, LEU71N, LYS10N, LYS120D, LYS17D, LYS52D, MET65N, PHE8N, PHE9N, PRO125D, PRO15D, SER16D, SER16N, THR11N, THR122D, THR124D, THR127D, TRP14D, TRP14N
• D-S: ALA42D, ALA45D, ARG41D, ASN162D, ASP252S, ASP39D, GLN255S, GLN257S, GLN36D, GLU250S, GLU44D, HIS40D, LEU37D, LEU38D, MET251S, SER254S, THR97D, TYR43D
• D-U: ASP160D, LYS116U
• E-F: ALA103F, ALA112E, ALA115E, ALA176F, ALA207E, ALA245E, ALA256E, ALA354E, ALA364E, ALA380E, ALA75E, ALA80F, ARG106E, ARG109E, ARG138F, ARG140F, ARG143F, ARG345E, ARG371E, ARG372E, ARG376E, ARG400E, ARG61F, ARG64F, ARG92F, ARG94F, ASN105F, ASN114E, ASN182F, ASN183F, ASN337E, ASN338E, ASN374E, ASN377E, ASN391E, ASN63F, ASP111E, ASP146F, ASP252E, ASP387E, ASP388E, ASP72E, ASP76F, ASP78F, ASP83F, ASP99F, CYS108E, CYS218E, GLN144F, GLN212E, GLN255E, GLN386E, GLN77F, GLU104F, GLU142F, GLU250E, GLU349E, GLU351E, GLU368E, GLU385E, GLU390E, GLU394E, GLU68F, GLU72F, GLU84F, GLU87F, GLY101F, GLY113E, GLY209E, GLY210E, GLY242E, GLY246E, GLY381E, GLY382E, GLY389E, GLY75F, GLY91F, HIS239E, HIS343E, HIS373E, HIS55F, HIS66E, HIS81F, HIS86F, ILE107E, ILE208E, ILE216E, ILE243E, ILE247E, ILE339E, ILE350E, ILE375E, ILE66F, ILE93F, LEU141F, LEU179F, LEU180F, LEU184F, LEU240E, LEU244E, LEU253E, LEU357E, LEU60F, LEU71F, LEU74E, LEU79F, LYS116E, LYS213E, LYS367E, LYS397E, LYS95F, MET186F, MET211E, MET251E, MET58F, MET65F, MET89F, PHE148F, PHE187F, PHE188F, PHE355E, PHE378E, PHE384E, PHE57F, PHE73E, PHE82F, PRO106F, PRO217E, PRO248E, PRO249E, PRO59F, SER110E, SER121E, SER177F, SER181F, SER185F, SER241E, SER379E, SER74F, SER98F, THR119E, THR178F, THR236E, THR237E, THR238E, THR356E, THR62F, THR85F, THR88F, THR97F, TRP102F, TRP214E, TRP353E, TRP392E, TYR370E, TYR56F, TYR77E, TYR90F, VAL100F, VAL215E, VAL352E, VAL358E, VAL383E, VAL393E, VAL96F
• E-G: ALA126E, ALA142E, ALA163E, ALA223G, ALA234G, ALA404G, ALA411G, ALA434G, ALA438G, ARG101E, ARG103E, ARG106E, ARG109E, ARG345E, ARG400G, ARG417G, ARG439G, ARG52E, ARG56E, ASN135E, ASN175E, ASN391G, ASN410G, ASN98E, ASP154E, ASP177E, ASP230G, ASP387G, ASP388G, ASP81E, CYS100E, CYS120E, GLN162E, GLN226G, GLN396G, GLN407G, GLN412G, GLN43G, GLN99E, GLU139E, GLU141E, GLU157E, GLU225G, GLU349E, GLU351E, GLU390G, GLU394G, GLU435G, GLU47E, GLU49E, GLU51E, GLU80E, GLY104E, GLY124E, GLY159E, GLY235G, GLY33G, GLY346E, GLY389G, GLY398G, GLY401G, GLY414G, GLY55E, GLY79E, HIS102E, HIS123E, HIS233G, HIS239G, HIS343E, ILE107E, ILE258G, ILE395G, ILE39G, LEU133E, LEU161E, LEU240G, LEU34G, LEU35G, LEU399G, LEU409G, LEU415G, LEU48E, LEU50E, LEU97E, LYS140E, LYS221G, LYS261G, LYS32G, LYS397G, LYS403G, LYS405G, MET105E, MET231G, MET413G, MET78E, PHE138E, PHE143E, PHE153E, PHE222G, PHE54E, PRO137E, PRO160E, PRO259G, PRO344E, PRO37G, PRO408G, PRO82E, SER121E, SER229G, SER406G, THR119E, THR236G, THR237G, THR238G, THR260G, TRP125E, TRP158E, TRP176E, TRP353E, TRP392G, TYR122E, TYR232G, TYR277G, TYR402G, TYR40G, TYR431G, TYR433G, TYR442G, TYR46E, TYR77E, VAL136E, VAL178E, VAL393G, VAL432G, VAL83E
• E-H: ALA103H, ALA112E, ALA75E, ARG106E, ARG109E, ARG109H, ARG140H, ARG143H, ARG345E, ASN105H, ASN98E, ASP111E, ASP99H, CYS108E, CYS120E, GLU104H, GLU142H, GLU349E, GLU351E, GLU80E, GLY101H, GLY124E, HIS343E, ILE216E, ILE350E, LEU141H, LYS213E, LYS95H, MET105E, PRO106H, PRO107H, PRO217E, PRO344E, PRO82E, SER110E, SER121E, THR119E, THR76E, TRP102H, TRP214E, TRP353E, TYR122E, TYR77E, VAL100H, VAL215E, VAL352E
• F-H: ALA133F, ALA149F, ALA176F, ALA18F, ALA19F, ALA35H, ALA42H, ALA45H, ALA48H, ARG109H, ARG111H, ARG138H, ARG140H, ARG143H, ARG152F, ARG152H, ARG153F, ARG33H, ARG41H, ARG61F, ARG64F, ARG67F, ARG94H, ASN105H, ASN116F, ASN116H, ASN131F, ASN139H, ASN161H, ASN162H, ASN25F, ASN25H, ASN63F, ASP146F, ASP146H, ASP160H, ASP175F, ASP39H, ASP99H, GLN144H, GLN24F, GLN24H, GLN29H, GLN36H, GLU104H, GLU13F, GLU142H, GLU151F, GLU22F, GLU22H, GLU26H, GLU28F, GLU28H, GLU34H, GLU44H, GLU68F, GLU72F, GLY101H, GLY150F, GLY164H, GLY20F, GLY20H, GLY69F, HIS112F, HIS112H, HIS40H, HIS7F, ILE118F, ILE135F, ILE135H, ILE147F, ILE147H, ILE172F, ILE66F, ILE93H, LEU113F, LEU113H, LEU136F, LEU136H, LEU141H, LEU163H, LEU173F, LEU174F, LEU179F, LEU180F, LEU21F, LEU21H, LEU23F, LEU23H, LEU37H, LYS10F, LYS17F, LYS95H, MET65F, PHE134F, PHE134H, PHE148F, PHE148H, PHE30H, PHE8F, PRO106H, PRO107H, PRO15F, PRO6F, SER108H, SER115F, SER115H, SER132F, SER16F, SER177F, SER181F, SER98H, THR110H, THR11F, THR178F, THR62F, THR97H, TRP102H, TRP14F, TYR137F, TYR137H, TYR31H, TYR32F, TYR32H, TYR43H, TYR73F, TYR90H, VAL100H, VAL114F, VAL114H, VAL117F, VAL117H, VAL119F, VAL130F, VAL145F, VAL145H, VAL96H
• F-K: ALA42F, ALA45F, ARG41F, ASN162F, ASP252K, ASP39F, GLN255K, GLN257K, GLN36F, GLU250K, GLU44F, HIS40F, LEU37F, MET251K, SER254K, THR97F, TYR43F
• G-H: ALA103H, ALA112G, ALA115G, ALA176H, ALA207G, ALA245G, ALA256G, ALA354G, ALA364G, ALA380G, ALA75G, ALA80H, ARG106G, ARG109G, ARG138H, ARG140H, ARG143H, ARG345G, ARG371G, ARG372G, ARG376G, ARG400G, ARG61H, ARG64H, ARG92H, ARG94H, ASN105H, ASN114G, ASN182H, ASN183H, ASN337G, ASN338G, ASN374G, ASN377G, ASN391G, ASN63H, ASP111G, ASP146H, ASP252G, ASP387G, ASP388G, ASP72G, ASP76H, ASP78H, ASP83H, ASP99H, CYS108G, CYS218G, GLN144H, GLN212G, GLN386G, GLN77H, GLU104H, GLU142H, GLU250G, GLU349G, GLU351G, GLU368G, GLU385G, GLU390G, GLU394G, GLU68H, GLU72H, GLU84H, GLU87H, GLY101H, GLY113G, GLY209G, GLY210G, GLY242G, GLY246G, GLY381G, GLY382G, GLY389G, GLY75H, GLY91H, HIS239G, HIS343G, HIS373G, HIS55H, HIS66G, HIS81H, ILE208G, ILE216G, ILE243G, ILE247G, ILE339G, ILE350G, ILE375G, ILE66H, ILE93H, LEU141H, LEU179H, LEU180H, LEU184H, LEU240G, LEU244G, LEU253G, LEU357G, LEU60H, LEU71H, LEU74G, LEU79H, LYS213G, LYS367G, LYS397G, LYS95H, MET186H, MET211G, MET251G, MET58H, MET65H, MET89H, PHE148H, PHE187H, PHE188H, PHE355G, PHE378G, PHE384G, PHE57H, PHE73G, PHE82H, PRO106H, PRO217G, PRO248G, PRO249G, PRO290G, PRO59H, SER110G, SER121G, SER177H, SER181H, SER185H, SER241G, SER254G, SER379G, SER74H, SER98H, THR119G, THR178H, THR236G, THR237G, THR238G, THR356G, THR62H, THR85H, THR88H, THR97H, TRP102H, TRP214G, TRP353G, TRP392G, TYR370G, TYR56H, TYR77G, TYR90H, VAL100H, VAL215G, VAL352G, VAL358G, VAL383G, VAL393G, VAL96H
• G-S: ALA115G, ARG317S, ASN114G, ASP72G, GLN294S, GLU298S, GLU303S, GLU365S, GLU69G, GLY299S, GLY71G, ILE366S, LYS116G, LYS291S, LYS89G, LYS91G, PRO290S, PRO300S, PRO68G, THR297S, THR70G
• G-T: ALA123T, ALA168T, ALA364G, ARG157T, ARG158T, ARG371G, ARG372G, ASP126T, ASP160T, ASP51T, ASP53T, GLN294G, GLU365G, GLU368G, GLU369G, HIS55T, HIS86T, ILE366G, ILE375G, ILE54T, LEU50T, LYS169T, LYS291G, LYS367G, LYS52T, PRO125T, PRO249G, PRO290G, PRO363G, SER166T, THR124T, THR127T, VAL155T
• H-S: ALA234S, ALA256S, ALA286S, ARG153H, ARG61H, ARG67H, ASP252S, ASP76H, GLN255S, GLN257S, GLN294S, GLU13H, GLU151H, GLU250S, GLU280S, GLU68H, GLU70H, GLU72H, GLY235S, GLY246S, GLY282S, GLY289S, GLY69H, GLY75H, HIS233S, HIS239S, HIS55H, HIS7H, ILE172H, ILE243S, ILE247S, ILE258S, ILE66H, LEU173H, LEU240S, LEU244S, LEU253S, LEU285S, LEU60H, LEU71H, LYS10H, LYS261S, MET231S, MET251S, PHE12H, PHE384S, PHE57H, PHE8H, PHE9H, PRO248S, PRO249S, PRO259S, PRO281S, PRO290S, PRO59H, PRO6H, SER241S, SER254S, SER283S, SER74H, THR11H, THR171H, THR236S, THR237S, THR238S, THR260S, TRP14H, TYR232S, TYR277S, TYR433S, TYR73H
• H-T: ALA123H, ALA159T, ALA168H, ALA42T, ALA45T, ALA48T, ARG153H, ARG157H, ARG41T, ARG94T, ASN161T, ASN162T, ASP154H, ASP160T, ASP51H, ASP51T, ASP53H, ASP53T, ASP76H, ASP83H, ASP99T, GLN77H, GLU121H, GLU129H, GLU13H, GLU44T, GLU84H, GLU87H, GLU87T, GLY164T, GLY75H, GLY91T, HIS40T, HIS55H, HIS86H, HIS86T, ILE54H, ILE54T, ILE93T, LEU163T, LEU37T, LEU49T, LEU50T, LYS10H, LYS120H, LYS169H, LYS17H, LYS52H, LYS52T, MET89T, PHE12H, PHE47H, PHE47T, PHE57H, PHE9H, PRO107T, PRO125H, SER166H, SER16H, SER98T, THR122H, THR124H, THR127H, THR171H, THR85H, THR85T, THR88H, THR88T, THR97T, TRP102T, TRP14H, TRP46T, TYR43T, TYR56H, TYR90H, TYR90T, VAL100T, VAL155H, VAL96T
• H-U: ALA115U, ALA117U, ALA126U, ASN135U, ASP128U, CYS120U, GLY124U, HIS123U, HIS7H, LYS116U, PHE118U, PHE12H, PHE138U, PHE9H, PRO137U, PRO15H, SER121U, THR119U, THR11H, TRP125U, TRP14H, TYR127U, VAL136U
• H-V: ARG158H, ARG67V, ASP126H, ASP160H, GLU121H, GLU13V, GLU68V, GLU70V, LYS10V, LYS17H
• I-J: ALA103J, ALA112I, ALA115I, ALA176J, ALA207I, ALA245I, ALA256I, ALA354I, ALA364I, ALA380I, ALA75I, ALA80J, ARG106I, ARG109I, ARG138J, ARG140J, ARG143J, ARG340I, ARG345I, ARG371I, ARG372I, ARG376I, ARG400I, ARG61J, ARG64J, ARG92J, ARG94J, ASN105J, ASN114I, ASN182J, ASN183J, ASN337I, ASN338I, ASN374I, ASN377I, ASN391I, ASN63J, ASP111I, ASP146J, ASP252I, ASP387I, ASP388I, ASP72I, ASP76J, ASP78J, ASP83J, ASP99J, CYS108I, CYS218I, GLN144J, GLN212I, GLN255I, GLN386I, GLN77J, GLU104J, GLU142J, GLU250I, GLU349I, GLU351I, GLU368I, GLU385I, GLU390I, GLU394I, GLU68J, GLU72J, GLU84J, GLU87J, GLY101J, GLY113I, GLY209I, GLY210I, GLY242I, GLY246I, GLY381I, GLY382I, GLY389I, GLY75J, GLY91J, HIS239I, HIS343I, HIS373I, HIS55J, HIS66I, HIS81J, HIS86J, ILE107I, ILE208I, ILE216I, ILE243I, ILE247I, ILE339I, ILE350I, ILE375I, ILE54J, ILE66J, ILE93J, LEU141J, LEU179J, LEU180J, LEU184J, LEU240I, LEU244I, LEU253I, LEU357I, LEU60J, LEU71J, LEU74I, LEU79J, LYS213I, LYS367I, LYS397I, LYS95J, MET186J, MET211I, MET251I, MET58J, MET65J, MET89J, PHE148J, PHE187J, PHE188J, PHE355I, PHE378I, PHE384I, PHE47J, PHE57J, PHE73I, PHE82J, PRO106J, PRO217I, PRO248I, PRO249I, PRO290I, PRO59J, PRO6J, SER110I, SER121I, SER177J, SER181J, SER185J, SER241I, SER379I, SER74J, SER98J, THR119I, THR178J, THR236I, THR237I, THR238I, THR356I, THR62J, THR85J, THR88J, THR97J, TRP102J, TRP214I, TRP353I, TRP392I, TYR370I, TYR56J, TYR77I, TYR90J, VAL100J, VAL215I, VAL352I, VAL358I, VAL383I, VAL393I, VAL96J
• I-O: ALA126O, ALA142O, ALA163O, ALA223I, ALA234I, ALA404I, ALA411I, ALA434I, ALA438I, ARG101O, ARG103O, ARG106O, ARG109O, ARG345O, ARG400I, ARG417I, ARG439I, ARG52O, ARG56O, ASN135O, ASN175O, ASN391I, ASN410I, ASN98O, ASP154O, ASP177O, ASP230I, ASP387I, ASP388I, ASP81O, CYS100O, CYS108O, CYS120O, GLN162O, GLN226I, GLN396I, GLN407I, GLN412I, GLN43I, GLN99O, GLU139O, GLU141O, GLU157O, GLU225I, GLU349O, GLU351O, GLU390I, GLU394I, GLU435I, GLU47O, GLU49O, GLU51O, GLU80O, GLY104O, GLY124O, GLY159O, GLY235I, GLY33I, GLY346O, GLY389I, GLY398I, GLY401I, GLY414I, GLY55O, GLY79O, HIS102O, HIS123O, HIS233I, HIS239I, ILE107O, ILE258I, ILE395I, ILE39I, LEU133O, LEU161O, LEU240I, LEU34I, LEU35I, LEU399I, LEU409I, LEU415I, LEU48O, LEU50O, LEU97O, LYS140O, LYS155O, LYS221I, LYS261I, LYS32I, LYS397I, LYS403I, LYS405I, MET105O, MET231I, MET413I, MET78O, PHE138O, PHE143O, PHE153O, PHE222I, PHE227I, PHE54O, PRO137O, PRO160O, PRO259I, PRO344O, PRO37I, PRO408I, PRO82O, SER121O, SER229I, SER406I, THR119O, THR236I, THR237I, THR238I, THR260I, TRP125O, TRP158O, TRP176O, TRP353O, TRP392I, TYR122O, TYR232I, TYR277I, TYR402I, TYR40I, TYR431I, TYR433I, TYR442I, TYR46O, TYR77O, VAL136O, VAL178O, VAL393I, VAL432I, VAL83O
• I-P: LYS397I, THR178P
• J-O: ALA103J, ALA75O, ARG106O, ARG109J, ARG109O, ARG140J, ARG143J, ARG345O, ASN105J, ASP111O, ASP99J, CYS108O, CYS120O, GLU104J, GLU142J, GLU349O, GLU351O, GLU80O, GLY101J, GLY124O, GLY346O, HIS343O, ILE216O, ILE350O, LEU141J, LYS213O, MET105O, PRO106J, PRO107J, PRO217O, PRO344O, PRO82O, SER110O, SER121O, THR119O, THR76O, TRP102J, TRP214O, TRP353O, TYR122O, TYR77O, VAL100J, VAL215O, VAL352O
• J-P: ALA103J, ALA133P, ALA149P, ALA176P, ALA18P, ALA19P, ALA35J, ALA42J, ALA45J, ARG109J, ARG111J, ARG138J, ARG140J, ARG143J, ARG152J, ARG152P, ARG153P, ARG33J, ARG41J, ARG61P, ARG64P, ARG67P, ASN105J, ASN116J, ASN116P, ASN131P, ASN139J, ASN161J, ASN162J, ASN25J, ASN25P, ASN63P, ASP146P, ASP175P, ASP39J, ASP99J, GLN144J, GLN24J, GLN24P, GLN29J, GLN36J, GLU104J, GLU13P, GLU142J, GLU151P, GLU22J, GLU22P, GLU26J, GLU28J, GLU28P, GLU34J, GLU68P, GLU72P, GLY101J, GLY150P, GLY164J, GLY20J, GLY20P, GLY69P, HIS112J, HIS112P, HIS40J, ILE118P, ILE135J, ILE135P, ILE147J, ILE147P, ILE172P, ILE66P, LEU113J, LEU113P, LEU136J, LEU136P, LEU141J, LEU163J, LEU173P, LEU174P, LEU179P, LEU180P, LEU21J, LEU21P, LEU23J, LEU23P, LEU37J, LEU38J, LEU49J, LYS10P, LYS17P, LYS95J, MET65P, PHE12P, PHE134J, PHE134P, PHE148J, PHE148P, PHE30J, PHE8P, PHE9P, PRO106J, PRO107J, PRO15P, SER108J, SER115J, SER115P, SER132P, SER16P, SER177P, SER181P, SER98J, THR110J, THR11P, THR178P, THR62P, THR97J, TRP102J, TRP14P, TRP46J, TYR137J, TYR137P, TYR31J, TYR32J, TYR32P, TYR43J, TYR73P, VAL100J, VAL114J, VAL114P, VAL117J, VAL117P, VAL119P, VAL145J, VAL96J
• K-L: ALA103L, ALA112K, ALA115K, ALA176L, ALA207K, ALA245K, ALA256K, ALA354K, ALA364K, ALA380K, ALA75K, ALA80L, ARG106K, ARG109K, ARG138L, ARG140L, ARG143L, ARG340K, ARG345K, ARG371K, ARG372K, ARG376K, ARG400K, ARG61L, ARG64L, ARG92L, ARG94L, ASN105L, ASN114K, ASN182L, ASN183L, ASN337K, ASN338K, ASN374K, ASN377K, ASN391K, ASN63L, ASP111K, ASP146L, ASP252K, ASP387K, ASP388K, ASP72K, ASP76L, ASP78L, ASP83L, ASP99L, CYS108K, CYS218K, GLN144L, GLN212K, GLN255K, GLN386K, GLN77L, GLU104L, GLU142L, GLU250K, GLU349K, GLU351K, GLU368K, GLU385K, GLU390K, GLU394K, GLU68L, GLU72L, GLU84L, GLU87L, GLY101L, GLY113K, GLY209K, GLY210K, GLY242K, GLY246K, GLY381K, GLY382K, GLY389K, GLY75L, GLY91L, HIS233K, HIS239K, HIS343K, HIS373K, HIS55L, HIS66K, HIS81L, ILE208K, ILE216K, ILE243K, ILE247K, ILE339K, ILE350K, ILE375K, ILE66L, ILE93L, LEU141L, LEU179L, LEU180L, LEU184L, LEU240K, LEU244K, LEU253K, LEU357K, LEU60L, LEU71L, LEU74K, LEU79L, LYS213K, LYS367K, LYS397K, LYS52L, LYS95L, MET186L, MET211K, MET251K, MET58L, MET65L, MET89L, PHE148L, PHE187L, PHE188L, PHE355K, PHE378K, PHE384K, PHE57L, PHE73K, PHE82L, PRO106L, PRO217K, PRO248K, PRO249K, PRO290K, PRO59L, SER110K, SER121K, SER177L, SER181L, SER185L, SER241K, SER379K, SER74L, SER98L, THR178L, THR236K, THR237K, THR238K, THR356K, THR62L, THR85L, THR88L, THR97L, TRP102L, TRP214K, TRP353K, TRP392K, TYR370K, TYR56L, TYR90L, VAL100L, VAL215K, VAL352K, VAL383K, VAL393K, VAL96L
• K-M: ALA126M, ALA142M, ALA163M, ALA223K, ALA234K, ALA404K, ALA411K, ALA434K, ALA438K, ARG101M, ARG103M, ARG106M, ARG109M, ARG345M, ARG400K, ARG417K, ARG439K, ARG52M, ARG56M, ASN135M, ASN175M, ASN391K, ASN410K, ASN98M, ASP154M, ASP177M, ASP230K, ASP387K, ASP388K, ASP81M, CYS100M, CYS108M, CYS120M, GLN162M, GLN226K, GLN396K, GLN407K, GLN412K, GLN99M, GLU139M, GLU141M, GLU157M, GLU225K, GLU349M, GLU351M, GLU390K, GLU394K, GLU435K, GLU47M, GLU49M, GLU51M, GLU80M, GLY104M, GLY124M, GLY159M, GLY235K, GLY33K, GLY346M, GLY389K, GLY398K, GLY401K, GLY414K, GLY55M, GLY79M, HIS102M, HIS123M, HIS233K, HIS239K, HIS343M, ILE107M, ILE258K, ILE395K, ILE39K, LEU133M, LEU161M, LEU240K, LEU34K, LEU35K, LEU399K, LEU409K, LEU415K, LEU48M, LEU50M, LEU97M, LYS140M, LYS221K, LYS32K, LYS397K, LYS403K, LYS405K, MET105M, MET231K, MET413K, MET78M, PHE138M, PHE143M, PHE153M, PHE222K, PHE54M, PRO137M, PRO160M, PRO259K, PRO344M, PRO37K, PRO408K, PRO82M, SER121M, SER229K, SER406K, THR119M, THR236K, THR237K, THR238K, THR260K, TRP125M, TRP158M, TRP176M, TRP353M, TRP392K, TYR122M, TYR232K, TYR277K, TYR402K, TYR40K, TYR431K, TYR433K, TYR442K, TYR46M, TYR77M, VAL136M, VAL178M, VAL393K, VAL432K, VAL83M
• K-Q: ALA126K, ALA142K, ALA163K, ALA223Q, ALA234Q, ALA404Q, ALA411Q, ALA434Q, ALA438Q, ARG101K, ARG103K, ARG106K, ARG109K, ARG345K, ARG400Q, ARG417Q, ARG439Q, ARG52K, ARG56K, ASN135K, ASN175K, ASN391Q, ASN410Q, ASN98K, ASP154K, ASP177K, ASP230Q, ASP387Q, ASP388Q, ASP81K, CYS100K, CYS108K, CYS120K, GLN162K, GLN226Q, GLN396Q, GLN407Q, GLN412Q, GLN43Q, GLN99K, GLU139K, GLU141K, GLU157K, GLU225Q, GLU349K, GLU351K, GLU390Q, GLU394Q, GLU435Q, GLU47K, GLU49K, GLU51K, GLU80K, GLY104K, GLY124K, GLY159K, GLY235Q, GLY33Q, GLY346K, GLY398Q, GLY401Q, GLY414Q, GLY55K, GLY79K, HIS102K, HIS123K, HIS233Q, HIS239Q, HIS343K, ILE107K, ILE258Q, ILE395Q, ILE39Q, LEU133K, LEU161K, LEU240Q, LEU34Q, LEU35Q, LEU399Q, LEU409Q, LEU415Q, LEU48K, LEU50K, LEU97K, LYS140K, LYS221Q, LYS261Q, LYS32Q, LYS397Q, LYS403Q, LYS405Q, MET105K, MET231Q, MET413Q, MET441Q, MET78K, PHE138K, PHE143K, PHE153K, PHE222Q, PHE54K, PRO137K, PRO160K, PRO259Q, PRO344K, PRO37Q, PRO408Q, PRO82K, SER121K, SER229Q, SER406Q, THR119K, THR236Q, THR237Q, THR238Q, THR260Q, TRP125K, TRP158K, TRP176K, TRP353K, TRP392Q, TYR122K, TYR232Q, TYR277Q, TYR402Q, TYR40Q, TYR431Q, TYR433Q, TYR442Q, TYR46K, TYR77K, VAL136K, VAL178K, VAL393Q, VAL432Q, VAL83K
• K-R: ALA103R, ALA112K, ALA75K, ARG106K, ARG109K, ARG109R, ARG140R, ARG143R, ARG345K, ASN105R, ASN98K, ASP111K, ASP99R, CYS108K, CYS120K, GLU104R, GLU142R, GLU349K, GLU351K, GLU80K, GLY101R, GLY124K, GLY346K, HIS343K, ILE216K, ILE350K, LEU141R, LYS213K, MET105K, PHE73K, PRO106R, PRO107R, PRO217K, PRO344K, PRO82K, SER110K, SER121K, THR119K, THR76K, TRP102R, TRP214K, TRP353K, TYR122K, TYR77K, VAL100R, VAL215K, VAL352K
• L-M: ALA103L, ALA112M, ALA75M, ARG106M, ARG109L, ARG109M, ARG140L, ARG143L, ARG345M, ASN105L, ASP111M, ASP99L, CYS108M, CYS120M, GLU104L, GLU142L, GLU349M, GLU351M, GLU80M, GLY101L, GLY124M, GLY346M, HIS343M, ILE216M, ILE350M, LEU141L, LYS213M, MET105M, PRO106L, PRO107L, PRO217M, PRO344M, PRO82M, SER110M, SER121M, THR119M, THR76M, TRP102L, TRP214M, TRP353M, TYR122M, TYR77M, VAL100L, VAL215M, VAL352M
• L-N: ALA133N, ALA149N, ALA176N, ALA18N, ALA19N, ALA35L, ALA42L, ALA45L, ARG109L, ARG111L, ARG138L, ARG140L, ARG143L, ARG152L, ARG152N, ARG153N, ARG33L, ARG41L, ARG61N, ARG64N, ARG67N, ASN105L, ASN116L, ASN116N, ASN131N, ASN139L, ASN161L, ASN162L, ASN25L, ASN25N, ASN63N, ASP146N, ASP175N, ASP39L, ASP99L, GLN144L, GLN24L, GLN24N, GLN29L, GLN36L, GLU104L, GLU13N, GLU142L, GLU151N, GLU22L, GLU22N, GLU26L, GLU28L, GLU28N, GLU34L, GLU68N, GLU72N, GLY101L, GLY150N, GLY164L, GLY20L, GLY20N, GLY69N, HIS112L, HIS112N, HIS40L, ILE118N, ILE135L, ILE135N, ILE147L, ILE147N, ILE172N, ILE66N, LEU113L, LEU113N, LEU136L, LEU136N, LEU141L, LEU163L, LEU173N, LEU174N, LEU179N, LEU180N, LEU21L, LEU21N, LEU23L, LEU37L, LEU38L, LEU49L, LYS10N, LYS17N, LYS95L, MET65N, PHE12N, PHE134L, PHE134N, PHE148L, PHE148N, PHE30L, PHE8N, PHE9N, PRO106L, PRO107L, PRO15N, SER108L, SER115L, SER115N, SER132N, SER16N, SER177N, SER181N, SER98L, THR110L, THR11N, THR178N, THR62N, THR97L, TRP102L, TRP14N, TRP46L, TYR137L, TYR137N, TYR31L, TYR32L, TYR32N, TYR43L, TYR73N, VAL100L, VAL114L, VAL114N, VAL117L, VAL117N, VAL119N, VAL145L, VAL96L
• L-R: ALA133L, ALA133R, ALA149L, ALA176L, ALA18L, ALA19L, ALA35R, ALA42R, ALA45R, ARG109R, ARG111R, ARG138R, ARG140R, ARG143R, ARG152L, ARG152R, ARG153L, ARG33R, ARG41R, ARG61L, ARG64L, ARG67L, ASN105R, ASN116L, ASN116R, ASN131L, ASN139R, ASN161R, ASN162R, ASN25L, ASN25R, ASN63L, ASP146L, ASP146R, ASP175L, ASP39R, ASP99R, GLN144R, GLN24L, GLN24R, GLN29R, GLN36R, GLU104R, GLU13L, GLU142R, GLU151L, GLU22L, GLU22R, GLU26R, GLU28L, GLU28R, GLU34R, GLU68L, GLU72L, GLY101R, GLY150L, GLY164R, GLY20L, GLY20R, GLY69L, HIS112L, HIS112R, HIS40R, ILE118L, ILE135L, ILE135R, ILE147L, ILE147R, ILE172L, ILE66L, LEU113L, LEU113R, LEU136L, LEU136R, LEU141R, LEU163R, LEU173L, LEU174L, LEU179L, LEU180L, LEU21L, LEU21R, LEU23R, LEU37R, LEU38R, LEU49R, LYS10L, LYS17L, LYS95R, MET65L, PHE12L, PHE134L, PHE134R, PHE148L, PHE148R, PHE30R, PHE8L, PHE9L, PRO106R, PRO107R, PRO15L, SER108R, SER115L, SER115R, SER132L, SER16L, SER177L, SER181L, SER98R, THR110R, THR11L, THR178L, THR62L, THR97R, TRP102R, TRP14L, TRP46R, TYR137L, TYR137R, TYR31R, TYR32L, TYR32R, TYR43R, TYR73L, VAL100R, VAL114L, VAL114R, VAL117L, VAL117R, VAL119L, VAL145L, VAL145R, VAL96R
• M-N: ALA103N, ALA112M, ALA115M, ALA176N, ALA207M, ALA245M, ALA256M, ALA354M, ALA364M, ALA380M, ALA75M, ALA80N, ARG106M, ARG109M, ARG138N, ARG140N, ARG143N, ARG340M, ARG345M, ARG371M, ARG372M, ARG376M, ARG400M, ARG61N, ARG64N, ARG67N, ARG92N, ARG94N, ASN105N, ASN114M, ASN182N, ASN183N, ASN337M, ASN338M, ASN374M, ASN377M, ASN391M, ASN63N, ASP111M, ASP146N, ASP252M, ASP387M, ASP388M, ASP72M, ASP76N, ASP78N, ASP83N, ASP99N, CYS108M, CYS218M, GLN144N, GLN212M, GLN386M, GLN77N, GLU104N, GLU142N, GLU250M, GLU349M, GLU351M, GLU368M, GLU369M, GLU385M, GLU390M, GLU394M, GLU68N, GLU72N, GLU84N, GLU87N, GLY101N, GLY113M, GLY209M, GLY210M, GLY242M, GLY246M, GLY381M, GLY382M, GLY389M, GLY75N, GLY91N, HIS239M, HIS373M, HIS55N, HIS66M, HIS81N, ILE107M, ILE208M, ILE216M, ILE243M, ILE247M, ILE339M, ILE350M, ILE375M, ILE54N, ILE66N, ILE93N, LEU141N, LEU179N, LEU180N, LEU184N, LEU240M, LEU244M, LEU253M, LEU357M, LEU60N, LEU71N, LEU74M, LEU79N, LYS213M, LYS367M, LYS397M, LYS95N, MET186N, MET211M, MET251M, MET58N, MET65N, MET89N, PHE148N, PHE187N, PHE188N, PHE355M, PHE378M, PHE384M, PHE57N, PHE73M, PHE82N, PRO106N, PRO217M, PRO248M, PRO249M, PRO59N, SER110M, SER121M, SER177N, SER181N, SER185N, SER241M, SER254M, SER379M, SER74N, SER98N, THR119M, THR178N, THR236M, THR237M, THR238M, THR356M, THR62N, THR85N, THR88N, THR97N, TRP102N, TRP214M, TRP353M, TRP392M, TYR370M, TYR56N, TYR77M, TYR90N, VAL100N, VAL215M, VAL352M, VAL383M, VAL393M, VAL96N
• M-Q: ALA126Q, ALA142Q, ALA163Q, ALA223M, ALA234M, ALA404M, ALA411M, ALA434M, ALA438M, ARG101Q, ARG103Q, ARG106Q, ARG109Q, ARG345Q, ARG400M, ARG417M, ARG439M, ARG52Q, ARG56Q, ASN135Q, ASN175Q, ASN391M, ASN410M, ASN98Q, ASP154Q, ASP177Q, ASP230M, ASP387M, ASP388M, ASP42M, ASP81Q, CYS100Q, CYS108Q, CYS120Q, GLN162Q, GLN226M, GLN396M, GLN407M, GLN412M, GLN43M, GLN99Q, GLU139Q, GLU141Q, GLU157Q, GLU225M, GLU349Q, GLU351Q, GLU390M, GLU394M, GLU435M, GLU47Q, GLU49Q, GLU51Q, GLU80Q, GLY104Q, GLY124Q, GLY159Q, GLY235M, GLY33M, GLY346Q, GLY389M, GLY398M, GLY401M, GLY414M, GLY55Q, GLY79Q, HIS102Q, HIS123Q, HIS233M, HIS239M, HIS343Q, ILE107Q, ILE258M, ILE395M, ILE39M, LEU133Q, LEU161Q, LEU240M, LEU34M, LEU35M, LEU399M, LEU409M, LEU415M, LEU48Q, LEU50Q, LEU97Q, LYS140Q, LYS221M, LYS261M, LYS32M, LYS397M, LYS403M, LYS405M, MET105Q, MET231M, MET413M, MET441M, MET78Q, PHE138Q, PHE143Q, PHE153Q, PHE222M, PHE227M, PHE54Q, PRO137Q, PRO160Q, PRO259M, PRO344Q, PRO37M, PRO408M, PRO82Q, SER121Q, SER229M, SER406M, THR119Q, THR236M, THR237M, THR238M, THR260M, TRP125Q, TRP158Q, TRP176Q, TRP353Q, TRP392M, TYR122Q, TYR232M, TYR277M, TYR402M, TYR40M, TYR431M, TYR433M, TYR442M, TYR46Q, TYR77Q, VAL136Q, VAL178Q, VAL393M, VAL432M, VAL83Q
• M-R: LYS397M, THR178R
• N-Q: ALA103N, ALA75Q, ARG106Q, ARG109N, ARG109Q, ARG140N, ARG143N, ARG345Q, ASN105N, ASN98Q, ASP111Q, ASP99N, CYS108Q, CYS120Q, GLU104N, GLU142N, GLU349Q, GLU351Q, GLY101N, GLY124Q, HIS343Q, ILE216Q, ILE350Q, LEU141N, LYS213Q, MET105Q, PRO106N, PRO107N, PRO217Q, PRO344Q, PRO82Q, SER110Q, SER121Q, THR119Q, THR76Q, TRP102N, TRP214Q, TRP353Q, TYR122Q, TYR77Q, VAL100N, VAL215Q, VAL352Q
• N-R: ALA133R, ALA149R, ALA176R, ALA18R, ALA19R, ALA35N, ALA42N, ALA45N, ARG109N, ARG111N, ARG138N, ARG140N, ARG143N, ARG152N, ARG152R, ARG153R, ARG33N, ARG41N, ARG61R, ARG64R, ARG67R, ASN105N, ASN116N, ASN116R, ASN131R, ASN139N, ASN161N, ASN162N, ASN25N, ASN25R, ASN63R, ASP146N, ASP146R, ASP175R, ASP39N, ASP99N, GLN144N, GLN24N, GLN24R, GLN29N, GLN36N, GLU104N, GLU13R, GLU142N, GLU151R, GLU22N, GLU22R, GLU26N, GLU28N, GLU28R, GLU34N, GLU68R, GLU70R, GLU72R, GLY101N, GLY150R, GLY164N, GLY20N, GLY20R, GLY69R, HIS112N, HIS112R, HIS40N, ILE118R, ILE135N, ILE135R, ILE147N, ILE147R, ILE172R, ILE66R, LEU113N, LEU113R, LEU136N, LEU136R, LEU141N, LEU163N, LEU173R, LEU174R, LEU179R, LEU180R, LEU21N, LEU21R, LEU23N, LEU23R, LEU37N, LEU38N, LEU49N, LYS10R, LYS17R, LYS95N, MET65R, PHE12R, PHE134N, PHE134R, PHE148N, PHE148R, PHE30N, PHE8R, PHE9R, PRO106N, PRO107N, PRO15R, SER108N, SER115N, SER115R, SER132R, SER16R, SER177R, SER98N, THR110N, THR11R, THR178R, THR62R, THR97N, TRP102N, TRP14R, TRP46N, TYR137N, TYR137R, TYR31N, TYR32N, TYR32R, TYR43N, TYR73R, VAL100N, VAL114N, VAL114R, VAL117N, VAL117R, VAL119R, VAL145N, VAL145R, VAL96N
• N-U: ALA123N, ALA130U, ALA156U, ASP128U, LYS132U, LYS89U, LYS94U, PRO125N, THR122N, THR124N, VAL134U
• O-P: ALA103P, ALA112O, ALA115O, ALA176P, ALA207O, ALA245O, ALA256O, ALA354O, ALA364O, ALA380O, ALA75O, ALA80P, ARG106O, ARG109O, ARG138P, ARG140P, ARG143P, ARG340O, ARG345O, ARG371O, ARG372O, ARG376O, ARG400O, ARG61P, ARG64P, ARG92P, ARG94P, ASN105P, ASN114O, ASN182P, ASN183P, ASN337O, ASN338O, ASN374O, ASN377O, ASN391O, ASN63P, ASP111O, ASP146P, ASP252O, ASP387O, ASP388O, ASP72O, ASP76P, ASP78P, ASP83P, ASP99P, CYS108O, CYS218O, GLN144P, GLN212O, GLN255O, GLN386O, GLN77P, GLU104P, GLU142P, GLU250O, GLU349O, GLU351O, GLU368O, GLU385O, GLU390O, GLU394O, GLU68P, GLU72P, GLU84P, GLU87P, GLY101P, GLY113O, GLY209O, GLY210O, GLY242O, GLY246O, GLY381O, GLY382O, GLY389O, GLY75P, GLY91P, HIS239O, HIS343O, HIS373O, HIS55P, HIS66O, HIS81P, HIS86P, ILE208O, ILE216O, ILE243O, ILE247O, ILE339O, ILE350O, ILE375O, ILE66P, ILE93P, LEU141P, LEU179P, LEU180P, LEU184P, LEU240O, LEU244O, LEU253O, LEU357O, LEU60P, LEU71P, LEU74O, LEU79P, LYS213O, LYS367O, LYS397O, LYS95P, MET186P, MET211O, MET251O, MET58P, MET65P, MET89P, PHE118O, PHE148P, PHE187P, PHE188P, PHE355O, PHE378O, PHE384O, PHE57P, PHE73O, PHE82P, PRO106P, PRO217O, PRO248O, PRO249O, PRO59P, PRO6P, SER108P, SER110O, SER121O, SER177P, SER181P, SER185P, SER241O, SER379O, SER74P, SER98P, THR119O, THR178P, THR236O, THR237O, THR238O, THR356O, THR62P, THR85P, THR88P, THR97P, TRP102P, TRP214O, TRP353O, TRP392O, TYR370O, TYR56P, TYR77O, TYR90P, VAL100P, VAL215O, VAL352O, VAL383O, VAL393O, VAL96P
• Q-R: ALA103R, ALA112Q, ALA115Q, ALA176R, ALA207Q, ALA245Q, ALA256Q, ALA354Q, ALA364Q, ALA380Q, ALA75Q, ALA80R, ARG106Q, ARG109Q, ARG138R, ARG140R, ARG143R, ARG340Q, ARG345Q, ARG371Q, ARG372Q, ARG376Q, ARG400Q, ARG61R, ARG64R, ARG67R, ARG92R, ARG94R, ASN105R, ASN114Q, ASN182R, ASN183R, ASN337Q, ASN338Q, ASN374Q, ASN377Q, ASN391Q, ASN63R, ASP111Q, ASP146R, ASP252Q, ASP387Q, ASP388Q, ASP72Q, ASP76R, ASP78R, ASP83R, ASP99R, CYS108Q, CYS218Q, GLN144R, GLN212Q, GLN386Q, GLN77R, GLU104R, GLU142R, GLU250Q, GLU349Q, GLU351Q, GLU368Q, GLU385Q, GLU390Q, GLU394Q, GLU68R, GLU72R, GLU84R, GLU87R, GLY101R, GLY113Q, GLY209Q, GLY210Q, GLY242Q, GLY246Q, GLY381Q, GLY382Q, GLY389Q, GLY75R, GLY91R, HIS239Q, HIS373Q, HIS55R, HIS66Q, HIS81R, ILE208Q, ILE216Q, ILE243Q, ILE247Q, ILE339Q, ILE350Q, ILE375Q, ILE66R, ILE93R, LEU141R, LEU179R, LEU180R, LEU184R, LEU240Q, LEU244Q, LEU253Q, LEU357Q, LEU60R, LEU71R, LEU74Q, LEU79R, LYS213Q, LYS367Q, LYS397Q, LYS95R, MET186R, MET211Q, MET251Q, MET58R, MET65R, MET89R, PHE148R, PHE187R, PHE188R, PHE355Q, PHE378Q, PHE384Q, PHE57R, PHE73Q, PHE82R, PRO106R, PRO217Q, PRO248Q, PRO249Q, PRO290Q, PRO59R, SER108R, SER110Q, SER121Q, SER177R, SER181R, SER185R, SER241Q, SER254Q, SER379Q, SER74R, SER98R, THR178R, THR236Q, THR237Q, THR238Q, THR356Q, THR62R, THR85R, THR88R, THR97R, TRP102R, TRP214Q, TRP353Q, TRP392Q, TYR370Q, TYR56R, TYR77Q, TYR90R, VAL100R, VAL215Q, VAL352Q, VAL358Q, VAL383Q, VAL393Q, VAL96R
• S-T: ALA103T, ALA112S, ALA115S, ALA176T, ALA207S, ALA245S, ALA256S, ALA354S, ALA364S, ALA380S, ALA75S, ALA80T, ARG106S, ARG109S, ARG138T, ARG140T, ARG143T, ARG345S, ARG371S, ARG372S, ARG376S, ARG400S, ARG61T, ARG64T, ARG67T, ARG92T, ARG94T, ASN105T, ASN114S, ASN182T, ASN183T, ASN337S, ASN338S, ASN374S, ASN377S, ASN391S, ASN63T, ASP111S, ASP146T, ASP252S, ASP387S, ASP388S, ASP72S, ASP76T, ASP78T, ASP83T, ASP99T, CYS108S, CYS218S, GLN144T, GLN212S, GLN386S, GLN77T, GLU104T, GLU142T, GLU250S, GLU349S, GLU351S, GLU368S, GLU385S, GLU390S, GLU394S, GLU68T, GLU72T, GLU84T, GLU87T, GLY101T, GLY113S, GLY209S, GLY210S, GLY242S, GLY246S, GLY381S, GLY382S, GLY389S, GLY75T, GLY91T, HIS233S, HIS239S, HIS343S, HIS373S, HIS55T, HIS66S, HIS81T, ILE107S, ILE208S, ILE216S, ILE243S, ILE247S, ILE339S, ILE350S, ILE375S, ILE66T, ILE93T, LEU141T, LEU179T, LEU180T, LEU184T, LEU240S, LEU244S, LEU253S, LEU357S, LEU60T, LEU71T, LEU74S, LEU79T, LYS213S, LYS367S, LYS397S, LYS95T, MET186T, MET211S, MET251S, MET58T, MET65T, MET89T, PHE118S, PHE148T, PHE187T, PHE188T, PHE355S, PHE378S, PHE384S, PHE47T, PHE57T, PHE73S, PHE82T, PRO106T, PRO217S, PRO248S, PRO249S, PRO290S, PRO59T, SER108T, SER110S, SER121S, SER177T, SER181T, SER185T, SER241S, SER379S, SER74T, SER98T, THR119S, THR178T, THR236S, THR237S, THR238S, THR356S, THR62T, THR85T, THR88T, THR97T, TRP102T, TRP214S, TRP353S, TRP392S, TYR370S, TYR56T, TYR77S, TYR90T, VAL100T, VAL215S, VAL352S, VAL383S, VAL393S, VAL96T
• S-U: ALA126U, ALA142U, ALA163U, ALA223S, ALA234S, ALA404S, ALA411S, ALA434S, ALA438S, ARG101U, ARG103U, ARG106U, ARG109U, ARG345U, ARG400S, ARG417S, ARG439S, ARG52U, ARG56U, ASN135U, ASN175U, ASN18S, ASN18U, ASN391S, ASN410S, ASN98U, ASP154U, ASP177U, ASP230S, ASP387S, ASP388S, ASP42S, ASP81U, CYS100U, CYS108U, CYS120U, GLN162U, GLN226S, GLN396S, GLN407S, GLN412S, GLN43S, GLN99U, GLU139U, GLU141U, GLU157U, GLU225S, GLU390S, GLU394S, GLU435S, GLU47U, GLU49U, GLU51U, GLU80U, GLY104U, GLY124U, GLY159U, GLY235S, GLY33S, GLY389S, GLY398S, GLY401S, GLY414S, GLY55U, GLY79U, HIS102U, HIS123U, HIS233S, HIS239S, ILE107U, ILE258S, ILE395S, ILE39S, LEU133U, LEU161U, LEU240S, LEU34S, LEU35S, LEU399S, LEU409S, LEU415S, LEU48U, LEU50U, LEU97U, LYS140U, LYS221S, LYS261S, LYS32S, LYS397S, LYS403S, LYS405S, MET105U, MET231S, MET413S, MET441S, MET78U, PHE138U, PHE143U, PHE153U, PHE222S, PHE54U, PRO137U, PRO160U, PRO259S, PRO37S, PRO408S, PRO82U, SER121U, SER229S, SER406S, THR119U, THR236S, THR237S, THR238S, THR260S, TRP125U, TRP158U, TRP176U, TRP392S, TYR122U, TYR232S, TYR277S, TYR402S, TYR40S, TYR431S, TYR433S, TYR442S, TYR46U, TYR77U, VAL136U, VAL178U, VAL393S, VAL432S, VAL83U
• S-W: ALA142S, ALA404W, ARG101S, ARG103S, ARG106S, ARG109S, ARG345S, ARG400W, ARG417W, ASN410W, ASP230W, ASP81S, GLN99S, GLU141S, GLU225W, GLU390W, GLU394W, GLU435W, GLU51S, GLU80S, GLY124S, GLY414W, HIS102S, HIS123S, HIS233W, LYS397W, LYS403W, LYS405W, PRO408W, SER121S, THR237W, TYR402W
• S-X: ARG106S, ARG109S, ARG143X, ARG345S, ASP111S, GLU142X, GLU349S, GLU351S, LYS213S, TRP102X, TYR77S
• T-U: ALA103T, ALA112U, ALA75U, ARG106U, ARG109T, ARG109U, ARG140T, ARG143T, ARG345U, ASN105T, ASN98U, ASP111U, ASP99T, CYS108U, CYS120U, GLU104T, GLU142T, GLU349U, GLU351U, GLU80U, GLY101T, GLY124U, ILE216U, LEU141T, LYS213U, MET105U, PRO106T, PRO107T, PRO217U, PRO82U, SER110U, SER121U, THR119U, THR76U, TRP102T, TRP214U, TYR122U, TYR77U, VAL100T, VAL215U
• T-V: ARG109T, ARG111T, ARG41T, ARG61V, ARG67V, ASN105T, ASN116V, ASN131V, ASN63V, ASP175V, ASP39T, ASP99T, GLN29T, GLN36T, GLU151V, GLU72V, HIS112T, HIS40T, ILE66V, LYS10V, SER115V, SER177V, VAL114T, VAL117V
• T-X: ARG109X, ARG111X, ARG61T, ARG67T, ASN105X, ASN116T, ASN63T, ASP175T, ASP39X, ASP99X, GLU151T, GLU72T, HIS112X, HIS40X, ILE66T, LYS10T, SER115T, VAL114X
• U-V: ALA380U, ARG140V, ARG143V, ARG371U, ARG372U, ARG376U, ARG64V, ARG92V, ASN63V, ASP111U, ASP387U, ASP76V, ASP78V, ASP83V, GLU104V, GLU142V, GLU368U, GLU390U, GLU394U, GLU72V, GLU84V, GLY209U, GLY381U, LEU179V, LEU184V, LEU79V, LYS213U, LYS397U, LYS95V, TRP102V, VAL215U
• U-W: ALA404U, ARG101W, ARG103W, ARG106W, ARG109W, ARG345W, ARG400U, ARG417U, ASN410U, ASP230U, ASP81W, GLN99W, GLU141W, GLU225U, GLU390U, GLU394U, GLU435U, GLU51W, GLU80W, HIS102W, HIS123W, HIS233U, LYS397U, LYS403U, LYS405U, PRO137W, THR236U, THR238U, TYR122W, TYR232U, TYR402U
• V-W: ARG109W, ARG143V, ARG345W, ASP111W, GLU142V, GLU349W, GLU351W, LYS213W, TRP102V
• V-X: ARG109V, ARG111V, ARG41V, ARG61X, ARG67X, ASN105V, ASN116X, ASN63X, ASP175X, ASP39V, ASP99V, GLU151X, GLU72X, HIS112V, HIS40V, ILE66X, LEU141V, LYS10X, SER177X, VAL114V
• W-X: ALA112W, ALA380W, ARG140X, ARG143X, ARG371W, ARG372W, ARG376W, ARG64X, ARG92X, ARG94X, ASN114W, ASN63X, ASP111W, ASP252W, ASP387W, ASP76X, ASP78X, ASP83X, GLU104X, GLU142X, GLU368W, GLU390W, GLU394W, GLU68X, GLU72X, GLU84X, GLY209W, GLY381W, HIS239W, HIS81X, ILE247W, LEU179X, LEU184X, LEU244W, LEU79X, LYS213W, LYS397W, LYS95X, PRO248W, VAL215W