2XSH

crystal structure of p4 variant of biphenyl dioxygenase from burkholderia xenovorans lb400 in complex with 2,6 di chlorobiphenyl

• Total interactions analyzed: 66
• Total true interactions: 25
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 139
  • Norm. En. per Res.: -5.5636
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-127.6816	-105.5559	-497.77	-731.0075	164	22	10	19925	6	57	60
A-C	-108.9742	-171.3965	-492.971	-773.3418	139	24	7	17764	10	64	41
A-E	-101.832	-170.8729	-483.463	-756.1679	139	20	6	17553	9	63	40
A-F	-19.6556	6.1966	-68.9142	-82.3733	45	2	0	2550	6	14	14
B-C	-6.6464	6.5592	-64.5634	-64.6507	45	5	0	2557	7	14	14
B-D	-84.0296	-88.6807	-432.15	-604.8603	130	25	10	16427	10	40	39
B-F	-92.2979	-93.084	-447.688	-633.0699	129	17	9	16668	11	39	40
C-D	-136.3171	-110.6869	-499.733	-746.737	165	19	10	20250	6	56	59
C-E	-112.4908	-172.1268	-475.148	-759.7656	139	24	7	17646	10	64	41
D-E	-10.9656	6.2132	-69.6736	-74.426	45	1	0	2494	6	14	14
D-F	-71.8435	-134.0992	-436.981	-642.9237	131	29	9	16448	12	39	40
E-F	-124.27	-131.9318	-516.426	-772.6278	169	22	10	20611	8	57	62
G-H	-125.496	-109.1836	-497.848	-732.5275	167	20	10	20163	7	55	60
G-I	-107.0211	-181.8475	-473.713	-762.5816	141	30	7	17625	10	62	41
G-K	-85.5953	-162.0471	-468.365	-716.0074	139	22	7	17625	9	63	43
G-L	-14.0744	8.1915	-68.9255	-74.8084	45	5	0	2523	6	14	15
H-I	-13.8997	7.9505	-74.3824	-80.3316	45	4	0	2601	6	14	15
H-J	-110.9875	-145.6346	-425.035	-681.6571	130	15	9	16319	13	40	40
H-L	-83.9739	-74.0308	-428.528	-586.5326	130	15	9	16541	10	41	41
I-J	-87.4817	-111.7015	-507.623	-706.8061	168	20	10	20621	6	58	60
I-K	-111.2257	-160.1623	-473.214	-744.602	136	17	6	17490	9	63	40
I-L	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
J-K	-14.4706	7.9502	-71.6974	-78.2179	46	4	0	2601	6	14	14
J-L	-102.8525	-100.6219	-442.786	-646.2604	131	17	8	16632	12	40	40
K-L	-114.9066	-139.0279	-517.289	-771.2235	164	23	10	20569	8	58	59

Interface residues

• A-B: ALA103B, ALA112A, ALA115A, ALA176B, ALA207A, ALA245A, ALA256A, ALA354A, ALA364A, ALA380A, ALA75A, ALA80B, ARG106A, ARG109A, ARG138B, ARG140B, ARG143B, ARG340A, ARG345A, ARG371A, ARG372A, ARG376A, ARG400A, ARG61B, ARG64B, ARG92B, ARG94B, ASN105B, ASN114A, ASN182B, ASN183B, ASN337A, ASN338A, ASN374A, ASN377A, ASN391A, ASN63B, ASP111A, ASP146B, ASP252A, ASP387A, ASP388A, ASP72A, ASP76B, ASP78B, ASP83B, ASP99B, CYS108A, CYS218A, GLN144B, GLN212A, GLN386A, GLN77B, GLU104B, GLU142B, GLU250A, GLU349A, GLU351A, GLU368A, GLU385A, GLU390A, GLU394A, GLU68B, GLU72B, GLU84B, GLU87B, GLY101B, GLY113A, GLY209A, GLY210A, GLY242A, GLY246A, GLY381A, GLY382A, GLY389A, GLY75B, GLY91B, HIS239A, HIS373A, HIS55B, HIS66A, HIS81B, HIS86B, ILE208A, ILE216A, ILE243A, ILE247A, ILE339A, ILE350A, ILE375A, ILE66B, ILE93B, LEU141B, LEU179B, LEU180B, LEU184B, LEU240A, LEU244A, LEU253A, LEU357A, LEU60B, LEU71B, LEU74A, LEU79B, LYS213A, LYS367A, LYS397A, LYS95B, MET186B, MET211A, MET251A, MET58B, MET65B, MET89B, PHE148B, PHE187B, PHE188B, PHE355A, PHE378A, PHE384A, PHE57B, PHE73A, PHE82B, PRO106B, PRO217A, PRO248A, PRO249A, PRO59B, SER108B, SER110A, SER121A, SER177B, SER181B, SER185B, SER241A, SER254A, SER379A, SER74B, SER98B, THR119A, THR178B, THR236A, THR237A, THR238A, THR356A, THR62B, THR85B, THR88B, THR97B, TRP102B, TRP214A, TRP353A, TRP392A, TYR370A, TYR56B, TYR77A, TYR90B, VAL100B, VAL215A, VAL352A, VAL358A, VAL383A, VAL393A, VAL96B
• A-C: ALA126C, ALA142C, ALA163C, ALA223A, ALA234A, ALA404A, ALA411A, ALA434A, ALA438A, ARG101C, ARG103C, ARG106C, ARG109C, ARG345C, ARG400A, ARG417A, ARG439A, ARG52C, ARG56C, ASN135C, ASN175C, ASN391A, ASN410A, ASN98C, ASP154C, ASP177C, ASP230A, ASP387A, ASP388A, ASP81C, CYS100C, CYS108C, CYS120C, GLN162C, GLN226A, GLN396A, GLN407A, GLN412A, GLN43A, GLN43C, GLN99C, GLU139C, GLU141C, GLU157C, GLU225A, GLU349C, GLU351C, GLU390A, GLU394A, GLU435A, GLU47C, GLU49C, GLU51C, GLU80C, GLY104C, GLY124C, GLY159C, GLY235A, GLY33A, GLY346C, GLY389A, GLY398A, GLY401A, GLY414A, GLY55C, GLY79C, HIS102C, HIS123C, HIS233A, HIS239A, HIS343C, ILE107C, ILE258A, ILE395A, ILE39A, LEU133C, LEU161C, LEU240A, LEU34A, LEU35A, LEU399A, LEU409A, LEU415A, LEU48C, LEU50C, LEU97C, LYS140C, LYS155C, LYS221A, LYS261A, LYS32A, LYS397A, LYS403A, LYS405A, MET105C, MET231A, MET413A, MET441A, MET78C, PHE138C, PHE143C, PHE153C, PHE222A, PHE54C, PRO137C, PRO160C, PRO259A, PRO344C, PRO37A, PRO408A, PRO82C, SER121C, SER229A, SER406A, THR119C, THR236A, THR237A, THR238A, THR260A, TRP125C, TRP158C, TRP176C, TRP353C, TRP392A, TYR122C, TYR232A, TYR277A, TYR402A, TYR40A, TYR431A, TYR433A, TYR442A, TYR46C, TYR77C, VAL136C, VAL178C, VAL393A, VAL432A, VAL83C
• A-E: ALA126A, ALA142A, ALA163A, ALA223E, ALA234E, ALA404E, ALA411E, ALA434E, ALA438E, ARG101A, ARG103A, ARG106A, ARG109A, ARG345A, ARG400E, ARG417E, ARG439E, ARG52A, ARG56A, ASN135A, ASN175A, ASN391E, ASN410E, ASN98A, ASP154A, ASP177A, ASP230E, ASP387E, ASP388E, ASP81A, CYS100A, CYS108A, CYS120A, GLN162A, GLN226E, GLN396E, GLN407E, GLN412E, GLN43E, GLN99A, GLU139A, GLU141A, GLU157A, GLU225E, GLU349A, GLU351A, GLU390E, GLU394E, GLU435E, GLU47A, GLU49A, GLU51A, GLU80A, GLY104A, GLY124A, GLY159A, GLY235E, GLY33E, GLY346A, GLY389E, GLY398E, GLY401E, GLY414E, GLY55A, GLY79A, HIS102A, HIS123A, HIS233E, HIS239E, HIS343A, ILE107A, ILE258E, ILE395E, ILE39E, LEU133A, LEU161A, LEU240E, LEU34E, LEU35E, LEU399E, LEU409E, LEU415E, LEU48A, LEU50A, LEU97A, LYS140A, LYS155A, LYS221E, LYS261E, LYS32E, LYS397E, LYS403E, LYS405E, MET105A, MET231E, MET413E, MET441E, MET78A, PHE138A, PHE143A, PHE153A, PHE222E, PHE227E, PHE54A, PRO137A, PRO160A, PRO259E, PRO344A, PRO37E, PRO408E, PRO82A, SER121A, SER229E, SER406E, THR119A, THR236E, THR237E, THR238E, THR260E, TRP125A, TRP158A, TRP176A, TRP353A, TRP392E, TYR122A, TYR232E, TYR277E, TYR402E, TYR40E, TYR431E, TYR433E, TYR442E, TYR46A, TYR77A, VAL136A, VAL178A, VAL393E, VAL432E, VAL83A
• A-F: ALA103F, ALA112A, ALA75A, ARG106A, ARG109A, ARG109F, ARG140F, ARG143F, ARG345A, ASN105F, ASN98A, ASP111A, ASP99F, CYS108A, CYS120A, GLU104F, GLU142F, GLU349A, GLU351A, GLU80A, GLY101F, GLY124A, HIS343A, ILE216A, ILE350A, LEU141F, LYS213A, MET105A, PRO106F, PRO107F, PRO217A, PRO344A, PRO82A, SER110A, SER121A, THR119A, THR76A, TRP102F, TRP214A, TRP353A, TYR122A, TYR77A, VAL100F, VAL215A, VAL352A
• B-C: ALA103B, ALA112C, ALA75C, ARG106C, ARG109B, ARG109C, ARG140B, ARG143B, ARG345C, ASN105B, ASN98C, ASP111C, ASP99B, CYS108C, CYS120C, GLU104B, GLU142B, GLU349C, GLU351C, GLU80C, GLY101B, GLY124C, HIS343C, ILE216C, ILE350C, LEU141B, LYS213C, MET105C, PRO106B, PRO107B, PRO217C, PRO344C, PRO82C, SER110C, SER121C, THR119C, THR76C, TRP102B, TRP214C, TRP353C, TYR122C, TYR77C, VAL100B, VAL215C, VAL352C
• B-D: ALA133B, ALA133D, ALA149D, ALA176D, ALA18D, ALA19D, ALA35B, ALA42B, ALA45B, ARG109B, ARG111B, ARG138B, ARG140B, ARG143B, ARG152B, ARG152D, ARG153D, ARG33B, ARG41B, ARG61D, ARG64D, ARG67D, ASN105B, ASN116B, ASN116D, ASN131D, ASN139B, ASN161B, ASN162B, ASN25B, ASN25D, ASN63D, ASP146D, ASP175D, ASP39B, ASP99B, GLN144B, GLN24B, GLN24D, GLN29B, GLN36B, GLU104B, GLU13D, GLU142B, GLU151D, GLU22B, GLU22D, GLU26B, GLU28B, GLU28D, GLU34B, GLU68D, GLU72D, GLY101B, GLY150D, GLY164B, GLY20B, GLY20D, GLY69D, HIS112B, HIS112D, HIS40B, ILE118D, ILE135B, ILE135D, ILE147B, ILE147D, ILE172D, ILE66D, LEU113B, LEU113D, LEU136B, LEU136D, LEU141B, LEU163B, LEU173D, LEU174D, LEU179D, LEU180D, LEU21B, LEU21D, LEU23B, LEU37B, LEU38B, LEU49B, LYS10D, LYS17D, LYS95B, MET65D, PHE12D, PHE134B, PHE134D, PHE148B, PHE148D, PHE30B, PHE9D, PRO106B, PRO107B, PRO15D, SER108B, SER115B, SER115D, SER132D, SER16D, SER177D, SER181D, SER98B, THR110B, THR11D, THR178D, THR62D, THR97B, TRP102B, TRP14D, TRP46B, TYR137B, TYR137D, TYR31B, TYR32B, TYR32D, TYR43B, TYR73D, VAL100B, VAL114B, VAL114D, VAL117B, VAL117D, VAL119D, VAL145B, VAL96B
• B-F: ALA133B, ALA149B, ALA176B, ALA18B, ALA19B, ALA35F, ALA42F, ALA45F, ARG109F, ARG111F, ARG138F, ARG140F, ARG143F, ARG152B, ARG152F, ARG153B, ARG33F, ARG41F, ARG61B, ARG64B, ARG67B, ASN105F, ASN116B, ASN116F, ASN131B, ASN139F, ASN161F, ASN162F, ASN25B, ASN25F, ASN63B, ASP146B, ASP175B, ASP39F, ASP99F, GLN144F, GLN24B, GLN24F, GLN29F, GLN36F, GLU104F, GLU13B, GLU142F, GLU151B, GLU22B, GLU22F, GLU26F, GLU28B, GLU28F, GLU34F, GLU68B, GLU72B, GLY101F, GLY150B, GLY164F, GLY20B, GLY20F, GLY69B, HIS112B, HIS112F, HIS40F, ILE118B, ILE135B, ILE135F, ILE147B, ILE147F, ILE172B, ILE66B, LEU113B, LEU113F, LEU136B, LEU136F, LEU141F, LEU163F, LEU173B, LEU174B, LEU179B, LEU180B, LEU21B, LEU21F, LEU23F, LEU37F, LEU38F, LEU49F, LYS10B, LYS17B, LYS95F, MET65B, PHE12B, PHE134B, PHE134F, PHE148B, PHE148F, PHE30F, PHE9B, PRO106F, PRO107F, PRO15B, SER108F, SER115B, SER115F, SER132B, SER16B, SER177B, SER181B, SER98F, THR110F, THR11B, THR178B, THR62B, THR97F, TRP102F, TRP14B, TYR137B, TYR137F, TYR31F, TYR32B, TYR32F, TYR43F, TYR73B, VAL100F, VAL114B, VAL114F, VAL117B, VAL117F, VAL119B, VAL145B, VAL145F, VAL96F
• C-D: ALA103D, ALA112C, ALA115C, ALA176D, ALA207C, ALA245C, ALA256C, ALA354C, ALA364C, ALA380C, ALA75C, ALA80D, ARG106C, ARG109C, ARG138D, ARG140D, ARG143D, ARG340C, ARG345C, ARG371C, ARG372C, ARG376C, ARG400C, ARG61D, ARG64D, ARG67D, ARG92D, ARG94D, ASN105D, ASN114C, ASN182D, ASN183D, ASN337C, ASN338C, ASN374C, ASN377C, ASN391C, ASN63D, ASP111C, ASP146D, ASP252C, ASP387C, ASP388C, ASP72C, ASP76D, ASP78D, ASP83D, ASP99D, CYS108C, CYS218C, GLN144D, GLN212C, GLN255C, GLN386C, GLN77D, GLU104D, GLU142D, GLU250C, GLU349C, GLU351C, GLU368C, GLU385C, GLU390C, GLU394C, GLU68D, GLU72D, GLU84D, GLU87D, GLY101D, GLY113C, GLY209C, GLY210C, GLY242C, GLY246C, GLY381C, GLY382C, GLY389C, GLY75D, GLY91D, HIS233C, HIS239C, HIS373C, HIS55D, HIS66C, HIS81D, ILE208C, ILE216C, ILE243C, ILE247C, ILE339C, ILE350C, ILE375C, ILE66D, ILE93D, LEU141D, LEU179D, LEU180D, LEU184D, LEU240C, LEU244C, LEU253C, LEU357C, LEU60D, LEU71D, LEU74C, LEU79D, LYS213C, LYS367C, LYS397C, LYS95D, MET186D, MET211C, MET251C, MET58D, MET65D, MET89D, PHE148D, PHE187D, PHE188D, PHE355C, PHE378C, PHE384C, PHE57D, PHE73C, PHE82D, PRO106D, PRO217C, PRO248C, PRO249C, PRO59D, SER108D, SER110C, SER121C, SER177D, SER181D, SER185D, SER241C, SER379C, SER74D, SER98D, THR119C, THR178D, THR236C, THR237C, THR238C, THR356C, THR62D, THR85D, THR88D, THR97D, TRP102D, TRP214C, TRP353C, TRP392C, TYR370C, TYR56D, TYR77C, TYR90D, VAL100D, VAL215C, VAL352C, VAL358C, VAL383C, VAL393C, VAL96D
• C-E: ALA126E, ALA142E, ALA163E, ALA223C, ALA234C, ALA404C, ALA411C, ALA434C, ALA438C, ARG101E, ARG103E, ARG106E, ARG109E, ARG345E, ARG400C, ARG417C, ARG439C, ARG52E, ARG56E, ASN135E, ASN175E, ASN18C, ASN18E, ASN391C, ASN410C, ASN98E, ASP154E, ASP177E, ASP230C, ASP387C, ASP388C, ASP81E, CYS100E, CYS108E, CYS120E, GLN162E, GLN226C, GLN396C, GLN407C, GLN412C, GLN43C, GLN99E, GLU139E, GLU141E, GLU157E, GLU225C, GLU349E, GLU351E, GLU390C, GLU394C, GLU435C, GLU47E, GLU49E, GLU51E, GLU80E, GLY104E, GLY124E, GLY159E, GLY235C, GLY33C, GLY346E, GLY389C, GLY398C, GLY401C, GLY414C, GLY55E, GLY79E, HIS102E, HIS123E, HIS233C, HIS239C, HIS343E, ILE107E, ILE258C, ILE395C, ILE39C, LEU133E, LEU161E, LEU240C, LEU34C, LEU35C, LEU399C, LEU409C, LEU415C, LEU48E, LEU50E, LEU97E, LYS140E, LYS155E, LYS221C, LYS261C, LYS32C, LYS397C, LYS403C, LYS405C, MET105E, MET231C, MET413C, MET78E, PHE138E, PHE143E, PHE153E, PHE222C, PHE54E, PRO137E, PRO160E, PRO259C, PRO344E, PRO37C, PRO408C, PRO82E, SER121E, SER229C, SER406C, THR119E, THR236C, THR237C, THR238C, THR260C, TRP125E, TRP158E, TRP176E, TRP353E, TRP392C, TYR122E, TYR232C, TYR277C, TYR402C, TYR40C, TYR431C, TYR433C, TYR442C, TYR46E, TYR77E, VAL136E, VAL178E, VAL393C, VAL432C, VAL83E
• D-E: ALA103D, ALA112E, ALA75E, ARG106E, ARG109D, ARG109E, ARG140D, ARG143D, ARG345E, ASN105D, ASN98E, ASP111E, ASP99D, CYS108E, CYS120E, GLU104D, GLU142D, GLU349E, GLU351E, GLU80E, GLY101D, GLY124E, HIS343E, ILE216E, ILE350E, LEU141D, LYS213E, MET105E, PRO106D, PRO107D, PRO217E, PRO344E, PRO82E, SER110E, SER121E, THR119E, THR76E, TRP102D, TRP214E, TRP353E, TYR122E, TYR77E, VAL100D, VAL215E, VAL352E
• D-F: ALA133D, ALA133F, ALA149F, ALA176F, ALA18F, ALA19F, ALA35D, ALA42D, ALA45D, ARG109D, ARG111D, ARG138D, ARG140D, ARG143D, ARG152D, ARG152F, ARG153F, ARG33D, ARG41D, ARG61F, ARG64F, ARG67F, ASN105D, ASN116D, ASN116F, ASN131F, ASN139D, ASN161D, ASN162D, ASN25D, ASN25F, ASN63F, ASP146D, ASP146F, ASP175F, ASP39D, ASP99D, GLN144D, GLN24D, GLN24F, GLN29D, GLN36D, GLU104D, GLU13F, GLU142D, GLU151F, GLU22D, GLU22F, GLU26D, GLU28D, GLU28F, GLU34D, GLU68F, GLU72F, GLY101D, GLY150F, GLY164D, GLY20D, GLY20F, GLY69F, HIS112D, HIS112F, HIS40D, ILE118F, ILE135D, ILE135F, ILE147D, ILE147F, ILE172F, ILE66F, LEU113D, LEU113F, LEU136D, LEU136F, LEU141D, LEU163D, LEU173F, LEU174F, LEU179F, LEU180F, LEU21D, LEU21F, LEU23D, LEU37D, LEU38D, LEU49D, LYS10F, LYS17F, LYS95D, MET65F, PHE12F, PHE134D, PHE134F, PHE148D, PHE148F, PHE30D, PHE9F, PRO106D, PRO107D, PRO15F, SER108D, SER115D, SER115F, SER132F, SER16F, SER177F, SER181F, SER98D, THR110D, THR11F, THR178F, THR62F, THR97D, TRP102D, TRP14F, TRP46D, TYR137D, TYR137F, TYR31D, TYR32D, TYR32F, TYR43D, TYR73F, VAL100D, VAL114D, VAL114F, VAL117D, VAL117F, VAL119F, VAL145D, VAL96D
• E-F: ALA103F, ALA112E, ALA115E, ALA176F, ALA207E, ALA245E, ALA256E, ALA354E, ALA364E, ALA380E, ALA75E, ALA80F, ARG106E, ARG109E, ARG138F, ARG140F, ARG143F, ARG340E, ARG345E, ARG371E, ARG372E, ARG376E, ARG400E, ARG61F, ARG64F, ARG92F, ARG94F, ASN105F, ASN114E, ASN182F, ASN183F, ASN337E, ASN338E, ASN374E, ASN377E, ASN391E, ASN63F, ASP111E, ASP146F, ASP252E, ASP387E, ASP388E, ASP72E, ASP76F, ASP78F, ASP83F, ASP99F, CYS108E, CYS218E, GLN144F, GLN212E, GLN255E, GLN386E, GLN77F, GLU104F, GLU142F, GLU250E, GLU349E, GLU351E, GLU368E, GLU385E, GLU390E, GLU394E, GLU68F, GLU72F, GLU84F, GLU87F, GLY101F, GLY113E, GLY209E, GLY210E, GLY242E, GLY246E, GLY381E, GLY382E, GLY389E, GLY75F, GLY91F, HIS233E, HIS239E, HIS373E, HIS55F, HIS66E, HIS81F, HIS86F, ILE208E, ILE216E, ILE243E, ILE247E, ILE339E, ILE350E, ILE375E, ILE54F, ILE66F, ILE93F, LEU141F, LEU179F, LEU180F, LEU184F, LEU240E, LEU244E, LEU253E, LEU357E, LEU60F, LEU71F, LEU74E, LEU79F, LYS169F, LYS213E, LYS367E, LYS397E, LYS95F, MET186F, MET211E, MET251E, MET58F, MET65F, MET89F, PHE118E, PHE148F, PHE187F, PHE188F, PHE355E, PHE378E, PHE384E, PHE57F, PHE73E, PHE82F, PRO106F, PRO217E, PRO248E, PRO249E, PRO59F, SER108F, SER110E, SER121E, SER177F, SER181F, SER185F, SER241E, SER254E, SER379E, SER74F, SER98F, THR119E, THR178F, THR236E, THR237E, THR238E, THR356E, THR62F, THR85F, THR88F, THR97F, TRP102F, TRP214E, TRP353E, TRP392E, TYR370E, TYR56F, TYR77E, TYR90F, VAL100F, VAL215E, VAL352E, VAL358E, VAL383E, VAL393E, VAL96F
• G-H: ALA103H, ALA112G, ALA115G, ALA176H, ALA207G, ALA245G, ALA256G, ALA286G, ALA354G, ALA364G, ALA380G, ALA75G, ALA80H, ARG106G, ARG109G, ARG138H, ARG140H, ARG143H, ARG340G, ARG345G, ARG371G, ARG372G, ARG376G, ARG400G, ARG61H, ARG64H, ARG92H, ARG94H, ASN105H, ASN114G, ASN182H, ASN183H, ASN337G, ASN338G, ASN374G, ASN377G, ASN391G, ASN63H, ASP111G, ASP146H, ASP252G, ASP387G, ASP388G, ASP72G, ASP76H, ASP78H, ASP83H, ASP99H, CYS108G, CYS218G, GLN144H, GLN212G, GLN386G, GLN77H, GLU104H, GLU142H, GLU250G, GLU349G, GLU351G, GLU368G, GLU385G, GLU390G, GLU394G, GLU68H, GLU72H, GLU84H, GLU87H, GLY101H, GLY113G, GLY209G, GLY210G, GLY242G, GLY246G, GLY381G, GLY382G, GLY389G, GLY75H, GLY91H, HIS233G, HIS239G, HIS373G, HIS55H, HIS66G, HIS81H, ILE208G, ILE216G, ILE243G, ILE247G, ILE339G, ILE350G, ILE375G, ILE54H, ILE66H, ILE93H, LEU141H, LEU179H, LEU180H, LEU184H, LEU240G, LEU244G, LEU253G, LEU357G, LEU60H, LEU71H, LEU74G, LEU79H, LYS213G, LYS367G, LYS397G, LYS95H, MET186H, MET211G, MET251G, MET58H, MET65H, MET89H, PHE148H, PHE187H, PHE188H, PHE355G, PHE378G, PHE384G, PHE57H, PHE73G, PHE82H, PRO106H, PRO217G, PRO248G, PRO249G, PRO290G, PRO59H, SER108H, SER110G, SER121G, SER177H, SER181H, SER185H, SER241G, SER254G, SER379G, SER74H, SER98H, THR119G, THR178H, THR236G, THR237G, THR238G, THR356G, THR62H, THR85H, THR88H, THR97H, TRP102H, TRP214G, TRP353G, TRP392G, TYR370G, TYR56H, TYR77G, TYR90H, VAL100H, VAL215G, VAL352G, VAL358G, VAL383G, VAL393G, VAL96H
• G-I: ALA126I, ALA142I, ALA163I, ALA223G, ALA234G, ALA404G, ALA411G, ALA434G, ALA438G, ARG101I, ARG103I, ARG106I, ARG109I, ARG345I, ARG400G, ARG417G, ARG439G, ARG52I, ARG56I, ASN135I, ASN175I, ASN18G, ASN18I, ASN391G, ASN410G, ASN98I, ASP154I, ASP177I, ASP230G, ASP387G, ASP388G, ASP81I, CYS100I, CYS108I, CYS120I, GLN162I, GLN226G, GLN396G, GLN407G, GLN412G, GLN43G, GLN99I, GLU139I, GLU141I, GLU157I, GLU225G, GLU349I, GLU351I, GLU390G, GLU394G, GLU435G, GLU47I, GLU49I, GLU51I, GLU80I, GLY104I, GLY124I, GLY159I, GLY235G, GLY33G, GLY346I, GLY389G, GLY398G, GLY401G, GLY414G, GLY55I, GLY79I, HIS102I, HIS123I, HIS233G, HIS239G, HIS343I, ILE107I, ILE258G, ILE395G, ILE39G, LEU133I, LEU161I, LEU240G, LEU34G, LEU35G, LEU399G, LEU409G, LEU415G, LEU48I, LEU50I, LEU97I, LYS140I, LYS155I, LYS221G, LYS261G, LYS32G, LYS397G, LYS403G, LYS405G, MET105I, MET231G, MET413G, MET441G, MET78I, PHE138I, PHE143I, PHE153I, PHE222G, PHE227G, PHE54I, PRO137I, PRO160I, PRO259G, PRO344I, PRO37G, PRO408G, PRO82I, SER121I, SER229G, SER406G, THR119I, THR236G, THR237G, THR238G, THR260G, TRP125I, TRP158I, TRP176I, TRP353I, TRP392G, TYR122I, TYR232G, TYR277G, TYR402G, TYR40G, TYR431G, TYR433G, TYR442G, TYR46I, TYR77I, VAL136I, VAL178I, VAL393G, VAL432G, VAL83I
• G-K: ALA126G, ALA142G, ALA163G, ALA223K, ALA234K, ALA404K, ALA411K, ALA434K, ALA438K, ARG101G, ARG103G, ARG106G, ARG109G, ARG345G, ARG400K, ARG417K, ARG439K, ARG52G, ARG56G, ASN135G, ASN175G, ASN391K, ASN410K, ASN98G, ASP154G, ASP177G, ASP230K, ASP387K, ASP388K, ASP81G, CYS100G, CYS108G, CYS120G, GLN162G, GLN226K, GLN264K, GLN396K, GLN407K, GLN412K, GLN43K, GLN99G, GLU139G, GLU141G, GLU157G, GLU225K, GLU349G, GLU351G, GLU390K, GLU394K, GLU435K, GLU47G, GLU49G, GLU51G, GLU80G, GLY104G, GLY124G, GLY159G, GLY235K, GLY33K, GLY346G, GLY398K, GLY401K, GLY414K, GLY55G, GLY79G, HIS102G, HIS123G, HIS233K, HIS239K, HIS343G, ILE107G, ILE258K, ILE395K, ILE39K, LEU133G, LEU161G, LEU240K, LEU34K, LEU35K, LEU399K, LEU409K, LEU415K, LEU48G, LEU50G, LEU97G, LYS140G, LYS155G, LYS221K, LYS261K, LYS32K, LYS397K, LYS403K, LYS405K, MET105G, MET231K, MET413K, MET441K, MET78G, PHE138G, PHE143G, PHE153G, PHE222K, PHE227K, PHE54G, PRO137G, PRO160G, PRO259K, PRO344G, PRO37K, PRO408K, PRO82G, SER121G, SER229K, SER406K, THR119G, THR236K, THR237K, THR238K, THR260K, TRP125G, TRP158G, TRP176G, TRP353G, TRP392K, TYR122G, TYR232K, TYR277K, TYR402K, TYR40K, TYR431K, TYR433K, TYR442K, TYR46G, TYR77G, VAL136G, VAL178G, VAL393K, VAL432K, VAL83G
• G-L: ALA103L, ALA75G, ARG106G, ARG109G, ARG109L, ARG140L, ARG143L, ARG345G, ASN105L, ASN98G, ASP111G, ASP99L, CYS108G, CYS120G, GLU104L, GLU142L, GLU349G, GLU351G, GLU80G, GLY101L, GLY124G, GLY346G, HIS343G, ILE216G, ILE350G, LEU141L, LYS213G, MET105G, PRO106L, PRO107L, PRO217G, PRO344G, PRO82G, SER110G, SER121G, THR119G, THR76G, TRP102L, TRP214G, TRP353G, TYR122G, TYR77G, VAL100L, VAL215G, VAL352G
• H-I: ALA103H, ALA75I, ARG106I, ARG109H, ARG109I, ARG140H, ARG143H, ARG345I, ASN105H, ASN98I, ASP111I, ASP99H, CYS108I, CYS120I, GLU104H, GLU142H, GLU349I, GLU351I, GLU80I, GLY101H, GLY124I, GLY346I, HIS343I, ILE216I, ILE350I, LEU141H, LYS213I, MET105I, PRO106H, PRO107H, PRO217I, PRO344I, PRO82I, SER110I, SER121I, THR119I, THR76I, TRP102H, TRP214I, TRP353I, TYR122I, TYR77I, VAL100H, VAL215I, VAL352I
• H-J: ALA133H, ALA133J, ALA149J, ALA176J, ALA18J, ALA19J, ALA35H, ALA42H, ALA45H, ARG109H, ARG111H, ARG138H, ARG140H, ARG143H, ARG152H, ARG152J, ARG153J, ARG33H, ARG41H, ARG61J, ARG64J, ARG67J, ASN105H, ASN116H, ASN116J, ASN131J, ASN139H, ASN161H, ASN162H, ASN25H, ASN25J, ASN63J, ASP146J, ASP175J, ASP39H, ASP99H, GLN144H, GLN24H, GLN24J, GLN29H, GLN36H, GLU104H, GLU13J, GLU142H, GLU151J, GLU22H, GLU22J, GLU26H, GLU28H, GLU28J, GLU34H, GLU68J, GLU72J, GLY101H, GLY150J, GLY164H, GLY20H, GLY20J, GLY69J, HIS112H, HIS112J, HIS40H, ILE118J, ILE135H, ILE135J, ILE147H, ILE147J, ILE172J, ILE66J, LEU113H, LEU113J, LEU136H, LEU136J, LEU141H, LEU163H, LEU173J, LEU174J, LEU179J, LEU180J, LEU21H, LEU21J, LEU23H, LEU37H, LEU38H, LEU49H, LYS10J, LYS17J, LYS95H, MET65J, PHE12J, PHE134H, PHE134J, PHE148H, PHE148J, PHE30H, PHE9J, PRO106H, PRO107H, PRO15J, SER108H, SER115H, SER115J, SER132J, SER16J, SER177J, SER181J, SER98H, THR110H, THR11J, THR178J, THR62J, THR97H, TRP102H, TRP14J, TRP46H, TYR137H, TYR137J, TYR31H, TYR32H, TYR32J, TYR43H, TYR73J, VAL100H, VAL114H, VAL114J, VAL117H, VAL117J, VAL119J, VAL145H, VAL96H
• H-L: ALA133H, ALA149H, ALA176H, ALA18H, ALA19H, ALA35L, ALA42L, ALA45L, ARG109L, ARG111L, ARG138L, ARG140L, ARG143L, ARG152H, ARG152L, ARG153H, ARG33L, ARG41L, ARG61H, ARG64H, ARG67H, ASN105L, ASN116H, ASN116L, ASN131H, ASN139L, ASN161L, ASN162L, ASN25H, ASN25L, ASN63H, ASP146H, ASP175H, ASP39L, ASP99L, GLN144L, GLN24H, GLN24L, GLN29L, GLN36L, GLU104L, GLU13H, GLU142L, GLU151H, GLU22H, GLU22L, GLU26L, GLU28H, GLU28L, GLU34L, GLU68H, GLU72H, GLY101L, GLY150H, GLY164L, GLY20H, GLY20L, GLY69H, HIS112H, HIS112L, HIS40L, ILE118H, ILE135H, ILE135L, ILE147H, ILE147L, ILE172H, ILE66H, LEU113H, LEU113L, LEU136H, LEU136L, LEU141L, LEU163L, LEU173H, LEU174H, LEU179H, LEU180H, LEU21H, LEU21L, LEU23L, LEU37L, LEU38L, LEU49L, LYS10H, LYS17H, LYS95L, MET65H, PHE12H, PHE134H, PHE134L, PHE148H, PHE148L, PHE30L, PHE9H, PRO106L, PRO107L, PRO15H, SER108L, SER115H, SER115L, SER132H, SER16H, SER177H, SER181H, SER98L, THR110L, THR11H, THR178H, THR62H, THR97L, TRP102L, TRP14H, TRP46L, TYR137H, TYR137L, TYR31L, TYR32H, TYR32L, TYR43L, TYR73H, VAL100L, VAL114H, VAL114L, VAL117H, VAL117L, VAL119H, VAL145H, VAL145L, VAL96L
• I-J: ALA103J, ALA112I, ALA115I, ALA176J, ALA207I, ALA245I, ALA256I, ALA354I, ALA364I, ALA380I, ALA75I, ALA80J, ARG106I, ARG109I, ARG138J, ARG140J, ARG143J, ARG340I, ARG345I, ARG371I, ARG372I, ARG376I, ARG400I, ARG61J, ARG64J, ARG67J, ARG92J, ARG94J, ASN105J, ASN114I, ASN182J, ASN183J, ASN337I, ASN338I, ASN374I, ASN377I, ASN391I, ASN63J, ASP111I, ASP146J, ASP252I, ASP387I, ASP388I, ASP72I, ASP76J, ASP78J, ASP83J, ASP99J, CYS108I, CYS218I, GLN144J, GLN212I, GLN386I, GLN77J, GLU104J, GLU142J, GLU250I, GLU349I, GLU351I, GLU368I, GLU385I, GLU390I, GLU394I, GLU68J, GLU72J, GLU84J, GLU87J, GLY101J, GLY113I, GLY209I, GLY210I, GLY242I, GLY246I, GLY381I, GLY382I, GLY389I, GLY75J, GLY91J, HIS233I, HIS239I, HIS373I, HIS55J, HIS66I, HIS81J, HIS86J, ILE107I, ILE208I, ILE216I, ILE243I, ILE247I, ILE339I, ILE350I, ILE375I, ILE54J, ILE66J, ILE93J, LEU141J, LEU179J, LEU180J, LEU184J, LEU240I, LEU244I, LEU253I, LEU357I, LEU60J, LEU71J, LEU74I, LEU79J, LYS213I, LYS367I, LYS397I, LYS95J, MET186J, MET211I, MET251I, MET58J, MET65J, MET89J, PHE148J, PHE187J, PHE188J, PHE355I, PHE378I, PHE384I, PHE57J, PHE73I, PHE82J, PRO106J, PRO217I, PRO248I, PRO249I, PRO290I, PRO59J, SER108J, SER110I, SER121I, SER177J, SER181J, SER185J, SER241I, SER254I, SER379I, SER74J, SER98J, THR119I, THR178J, THR236I, THR237I, THR238I, THR356I, THR62J, THR85J, THR88J, THR97J, TRP102J, TRP214I, TRP353I, TRP392I, TYR370I, TYR56J, TYR77I, TYR90J, VAL100J, VAL215I, VAL352I, VAL383I, VAL393I, VAL96J
• I-K: ALA126K, ALA142K, ALA163K, ALA223I, ALA234I, ALA404I, ALA411I, ALA434I, ALA438I, ARG101K, ARG103K, ARG106K, ARG109K, ARG345K, ARG400I, ARG417I, ARG439I, ARG52K, ARG56K, ASN135K, ASN175K, ASN391I, ASN410I, ASN98K, ASP154K, ASP177K, ASP230I, ASP387I, ASP388I, ASP81K, CYS100K, CYS108K, CYS120K, GLN162K, GLN226I, GLN396I, GLN407I, GLN412I, GLN43I, GLN99K, GLU139K, GLU141K, GLU157K, GLU225I, GLU349K, GLU351K, GLU390I, GLU394I, GLU435I, GLU47K, GLU49K, GLU51K, GLU80K, GLY104K, GLY124K, GLY159K, GLY235I, GLY33I, GLY346K, GLY389I, GLY398I, GLY401I, GLY414I, GLY55K, GLY79K, HIS102K, HIS123K, HIS233I, HIS239I, ILE107K, ILE258I, ILE395I, ILE39I, LEU133K, LEU161K, LEU240I, LEU34I, LEU35I, LEU399I, LEU409I, LEU415I, LEU48K, LEU50K, LEU97K, LYS140K, LYS155K, LYS221I, LYS32I, LYS397I, LYS403I, LYS405I, MET105K, MET231I, MET413I, MET78K, PHE138K, PHE143K, PHE153K, PHE222I, PHE227I, PHE54K, PRO137K, PRO160K, PRO259I, PRO344K, PRO37I, PRO408I, PRO82K, SER121K, SER229I, SER406I, THR119K, THR236I, THR237I, THR238I, THR260I, TRP125K, TRP158K, TRP176K, TRP353K, TRP392I, TYR122K, TYR232I, TYR277I, TYR402I, TYR40I, TYR431I, TYR433I, TYR442I, TYR46K, TYR77K, VAL136K, VAL178K, VAL393I, VAL432I, VAL83K
• I-L: LYS397I, THR178L
• J-K: ALA103J, ALA112K, ALA75K, ARG106K, ARG109J, ARG109K, ARG140J, ARG143J, ARG345K, ASN105J, ASN98K, ASP111K, ASP99J, CYS108K, CYS120K, GLU104J, GLU142J, GLU349K, GLU351K, GLU80K, GLY101J, GLY124K, GLY346K, HIS343K, ILE216K, ILE350K, LEU141J, LYS213K, MET105K, PRO106J, PRO107J, PRO217K, PRO344K, PRO82K, SER110K, SER121K, THR119K, THR76K, TRP102J, TRP214K, TRP353K, TYR122K, TYR77K, VAL100J, VAL215K, VAL352K
• J-L: ALA133L, ALA149J, ALA149L, ALA176L, ALA18L, ALA19L, ALA35J, ALA42J, ALA45J, ARG109J, ARG111J, ARG138J, ARG140J, ARG143J, ARG152J, ARG152L, ARG153L, ARG33J, ARG41J, ARG61L, ARG64L, ARG67L, ASN105J, ASN116J, ASN116L, ASN131L, ASN139J, ASN161J, ASN162J, ASN25J, ASN25L, ASN63L, ASP146L, ASP175L, ASP39J, ASP99J, GLN144J, GLN24J, GLN24L, GLN29J, GLN36J, GLU104J, GLU13L, GLU142J, GLU151L, GLU22J, GLU22L, GLU26J, GLU28J, GLU28L, GLU34J, GLU68L, GLU72L, GLY101J, GLY150L, GLY164J, GLY20J, GLY20L, GLY69L, HIS112J, HIS112L, HIS40J, ILE118L, ILE135J, ILE135L, ILE147J, ILE147L, ILE172L, ILE66L, LEU113J, LEU113L, LEU136J, LEU136L, LEU141J, LEU163J, LEU173L, LEU174L, LEU179L, LEU180L, LEU21J, LEU21L, LEU23J, LEU23L, LEU37J, LEU38J, LEU49J, LYS10L, LYS17L, LYS95J, MET65L, PHE12L, PHE134J, PHE134L, PHE148J, PHE148L, PHE30J, PHE9L, PRO106J, PRO107J, PRO15L, SER108J, SER115J, SER115L, SER132L, SER16L, SER177L, SER181L, SER98J, THR110J, THR11L, THR178L, THR62L, THR97J, TRP102J, TRP14L, TRP46J, TYR137J, TYR137L, TYR31J, TYR32J, TYR32L, TYR43J, TYR73L, VAL100J, VAL114J, VAL114L, VAL117J, VAL117L, VAL119L, VAL145J, VAL96J
• K-L: ALA103L, ALA112K, ALA115K, ALA176L, ALA207K, ALA245K, ALA354K, ALA364K, ALA380K, ALA75K, ALA80L, ARG106K, ARG109K, ARG138L, ARG140L, ARG143L, ARG345K, ARG371K, ARG372K, ARG376K, ARG400K, ARG61L, ARG64L, ARG67L, ARG92L, ARG94L, ASN105L, ASN114K, ASN182L, ASN183L, ASN337K, ASN338K, ASN374K, ASN377K, ASN391K, ASN63L, ASP111K, ASP146L, ASP252K, ASP387K, ASP388K, ASP72K, ASP76L, ASP78L, ASP83L, ASP99L, CYS108K, CYS218K, GLN144L, GLN212K, GLN386K, GLN77L, GLU104L, GLU142L, GLU250K, GLU349K, GLU351K, GLU368K, GLU385K, GLU390K, GLU394K, GLU68L, GLU72L, GLU84L, GLU87L, GLY101L, GLY113K, GLY209K, GLY210K, GLY242K, GLY246K, GLY381K, GLY382K, GLY389K, GLY75L, GLY91L, HIS239K, HIS343K, HIS373K, HIS55L, HIS66K, HIS81L, HIS86L, ILE208K, ILE216K, ILE243K, ILE247K, ILE339K, ILE350K, ILE375K, ILE54L, ILE66L, ILE93L, LEU141L, LEU179L, LEU180L, LEU184L, LEU240K, LEU244K, LEU253K, LEU357K, LEU60L, LEU71L, LEU74K, LEU79L, LYS213K, LYS367K, LYS397K, LYS95L, MET186L, MET211K, MET251K, MET58L, MET65L, MET89L, PHE148L, PHE187L, PHE188L, PHE355K, PHE378K, PHE384K, PHE57L, PHE73K, PHE82L, PRO106L, PRO217K, PRO248K, PRO249K, PRO290K, PRO59L, SER108L, SER110K, SER121K, SER177L, SER181L, SER185L, SER241K, SER254K, SER379K, SER74L, SER98L, THR119K, THR178L, THR236K, THR237K, THR238K, THR356K, THR62L, THR85L, THR88L, THR97L, TRP102L, TRP214K, TRP353K, TRP392K, TYR370K, TYR56L, TYR90L, VAL100L, VAL215K, VAL352K, VAL383K, VAL393K, VAL96L