2VTX

activation of nucleoplasmin, an oligomeric histone chaperone, challenges its stability

• Total interactions analyzed: 45
• Total true interactions: 20
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 87
  • Norm. En. per Res.: -3.0989
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-12.1327	-7.2375	-240.241	-259.6112	86	4	5	10422	0	20	19
A-C	0.0	0.0	-0.2033	-0.2033	6	0	0	74	0	0	0
A-D	0.0	0.0	-0.2112	-0.2112	6	0	0	73	0	0	0
A-E	-11.2955	-8.9175	-236.494	-256.707	85	1	5	10328	0	18	19
B-C	-4.8998	-5.7862	-231.982	-242.6679	81	1	4	9869	0	17	15
B-D	0.0	0.0	-0.1941	-0.1941	5	0	0	72	0	0	0
B-E	0.0	0.0	-0.2137	-0.2137	5	0	0	74	0	0	0
C-D	-10.3007	1.9777	-231.678	-240.0009	85	6	4	10116	0	17	16
C-E	0.0	0.0	-0.223	-0.223	8	0	0	80	0	0	0
D-E	-10.5874	-5.7383	-229.927	-246.2527	84	7	5	10008	0	17	17
G-H	-20.4421	11.6124	-244.827	-253.6567	89	6	6	10371	0	23	23
G-I	0.0	0.0	-0.1971	-0.1971	6	0	0	75	0	0	0
G-J	0.0	0.0	-0.1867	-0.1867	6	0	0	73	0	0	0
G-K	-17.875	-8.129	-235.073	-261.0769	86	9	5	10297	0	19	15
H-I	-17.8333	6.2075	-241.648	-253.2738	88	7	6	10406	0	23	22
H-J	0.0	0.0	-0.2034	-0.2034	5	0	0	74	0	0	0
H-K	0.0	0.0	-0.1687	-0.1687	8	0	0	69	0	0	0
I-J	-24.0624	-9.5809	-235.965	-269.6083	87	6	4	10153	0	20	20
I-K	0.0	0.0	-0.2545	-0.2545	7	0	0	85	0	0	0
J-K	-22.7573	0.2258	-219.573	-242.1045	83	14	5	9878	0	17	14

Interface residues

• A-B: ALA106B, ALA46A, ALA56A, ALA79B, ALA89A, ALA89B, ARG48A, ASP16A, ASP54A, ASP58A, ASP67B, ASP97B, CYS21A, CYS51A, GLN116A, GLN44B, GLN68B, GLU22A, GLU59B, GLU64B, GLU95B, GLY107B, GLY115A, GLY20A, GLY53A, GLY93A, GLY93B, HIS117A, HIS61B, ILE113A, ILE18A, ILE62B, ILE65B, ILE78B, ILE85A, ILE85B, ILE94B, LEU111A, LEU17A, LEU45B, LEU47A, LEU47B, LEU52A, LEU81A, LEU81B, LEU86A, LEU86B, LEU96B, LYS105B, LYS55A, LYS74B, LYS82A, LYS82B, MET88A, MET88B, MET91A, MET91B, PHE102B, PHE30A, PHE32A, PHE60B, PRO110A, PRO77B, PRO83A, PRO87A, PRO87B, SER114A, SER75B, SER84A, SER84B, THR101B, THR49A, THR80B, THR90A, THR90B, TRP19A, TYR112A, VAL100B, VAL118A, VAL50A, VAL50B, VAL63B, VAL66B, VAL76B, VAL92A, VAL92B
• A-C: LEU86A, LEU86C, THR90A, THR90C, VAL92A, VAL92C
• A-D: LEU86A, LEU86D, THR90A, THR90D, VAL92A, VAL92D
• A-E: ALA106A, ALA46A, ALA46E, ALA56E, ALA79A, ALA89A, ALA89E, ARG48A, ARG48E, ASP16E, ASP54E, ASP58E, ASP67A, ASP97A, CYS21E, CYS51E, GLN116E, GLN44A, GLU22E, GLU59A, GLU64A, GLU95A, GLY107A, GLY115E, GLY20E, GLY53E, GLY93A, GLY93E, HIS117E, HIS61A, ILE113E, ILE18E, ILE62A, ILE65A, ILE78A, ILE85A, ILE85E, ILE94A, LEU111E, LEU17E, LEU45A, LEU47A, LEU47E, LEU52E, LEU81A, LEU81E, LEU86A, LEU86E, LEU96A, LYS105A, LYS55E, LYS74A, LYS82A, LYS82E, MET88A, MET88E, MET91A, MET91E, PHE102A, PHE60A, PRO110E, PRO77A, PRO83E, PRO87A, PRO87E, SER114E, SER75A, SER84A, SER84E, THR101A, THR49E, THR80A, THR90A, THR90E, TRP19E, TYR112E, VAL100A, VAL118E, VAL50A, VAL50E, VAL63A, VAL66A, VAL76A, VAL92A, VAL92E
• B-C: ALA106C, ALA46B, ALA56B, ALA79C, ALA89B, ALA89C, ARG48B, ARG48C, ASP54B, ASP58B, ASP67C, ASP97C, CYS21B, CYS51B, GLN116B, GLN44C, GLU22B, GLU59C, GLU64C, GLU95C, GLY107C, GLY115B, GLY20B, GLY53B, GLY93B, GLY93C, HIS61C, ILE113B, ILE18B, ILE62C, ILE65C, ILE78C, ILE85B, ILE85C, ILE94C, LEU111B, LEU17B, LEU45C, LEU47B, LEU47C, LEU52B, LEU81B, LEU81C, LEU86B, LEU86C, LEU96C, LYS105C, LYS55B, LYS74C, LYS82B, LYS82C, MET88B, MET88C, MET91B, MET91C, PHE102C, PHE60C, PRO110B, PRO77C, PRO83B, PRO87B, PRO87C, SER114B, SER75C, SER84B, SER84C, THR49B, THR80C, THR90B, THR90C, TRP19B, TYR112B, VAL100C, VAL118B, VAL50B, VAL50C, VAL63C, VAL66C, VAL76C, VAL92B, VAL92C
• B-D: LEU86B, LEU86D, THR90B, VAL92B, VAL92D
• B-E: LEU86B, LEU86E, THR90E, VAL92B, VAL92E
• C-D: ALA106D, ALA46C, ALA56C, ALA79D, ALA89C, ALA89D, ARG48C, ASP16C, ASP54C, ASP58C, ASP67D, ASP97D, CYS21C, CYS51C, GLN116C, GLN44D, GLN68D, GLU22C, GLU59D, GLU64D, GLU95D, GLY107D, GLY115C, GLY20C, GLY53C, GLY93C, GLY93D, HIS117C, HIS61D, ILE113C, ILE18C, ILE62D, ILE65D, ILE78D, ILE85C, ILE85D, ILE94C, ILE94D, LEU111C, LEU17C, LEU45D, LEU47C, LEU47D, LEU52C, LEU81C, LEU81D, LEU86C, LEU86D, LEU96D, LYS105D, LYS55C, LYS74D, LYS82C, LYS82D, MET88C, MET88D, MET91C, MET91D, PHE102D, PHE60D, PRO110C, PRO77D, PRO83C, PRO87C, PRO87D, SER114C, SER75D, SER84C, SER84D, THR101D, THR49C, THR80D, THR90C, THR90D, TRP19C, TYR112C, VAL100D, VAL118C, VAL50C, VAL50D, VAL63D, VAL66D, VAL76D, VAL92C, VAL92D
• C-E: ILE85C, ILE85E, LEU86C, LEU86E, THR90C, THR90E, VAL92C, VAL92E
• D-E: ALA106E, ALA46D, ALA46E, ALA56D, ALA79E, ALA89D, ALA89E, ARG48D, ARG48E, ASP54D, ASP58D, ASP67E, ASP97E, CYS21D, CYS51D, GLN116D, GLN44E, GLN68E, GLU22D, GLU59E, GLU64E, GLU95D, GLU95E, GLY107E, GLY115D, GLY20D, GLY53D, GLY93D, GLY93E, HIS61E, ILE113D, ILE18D, ILE62E, ILE65E, ILE78E, ILE85D, ILE85E, ILE94E, LEU111D, LEU17D, LEU45E, LEU47D, LEU47E, LEU52D, LEU81D, LEU81E, LEU86D, LEU86E, LEU96E, LYS105E, LYS55D, LYS74E, LYS82D, LYS82E, MET88D, MET88E, MET91D, MET91E, PHE102E, PHE60E, PRO110D, PRO77E, PRO83D, PRO87D, PRO87E, PRO98E, SER114D, SER75E, SER84D, SER84E, THR49D, THR80E, THR90D, THR90E, TRP19D, TYR112D, VAL100E, VAL50D, VAL50E, VAL63E, VAL66E, VAL76E, VAL92D, VAL92E
• G-H: ALA106H, ALA46G, ALA46H, ALA56G, ALA79H, ALA89G, ALA89H, ARG48G, ARG48H, ASP16G, ASP54G, ASP58G, ASP67H, ASP97H, CYS21G, CYS51G, GLN116G, GLN44H, GLN68H, GLU22G, GLU35G, GLU59H, GLU64H, GLU69H, GLU70H, GLU95H, GLY107H, GLY115G, GLY20G, GLY53G, GLY93G, GLY93H, HIS61H, ILE113G, ILE18G, ILE62H, ILE65H, ILE78H, ILE85G, ILE85H, ILE94H, LEU111G, LEU17G, LEU45H, LEU47G, LEU47H, LEU52G, LEU81G, LEU81H, LEU86G, LEU86H, LEU96H, LYS105H, LYS55G, LYS74H, LYS82G, LYS82H, MET88G, MET88H, MET91G, MET91H, PHE102H, PHE60H, PRO110G, PRO77H, PRO83G, PRO87G, PRO87H, SER114G, SER75H, SER84G, SER84H, THR101H, THR49G, THR49H, THR80H, THR90G, THR90H, TRP19G, TYR112G, VAL100H, VAL118G, VAL50G, VAL50H, VAL63H, VAL66H, VAL76H, VAL92G, VAL92H
• G-I: LEU86G, LEU86I, THR90G, THR90I, VAL92G, VAL92I
• G-J: LEU86G, LEU86J, THR90G, THR90J, VAL92G, VAL92J
• G-K: ALA106G, ALA46K, ALA56K, ALA79G, ALA89G, ALA89K, ARG48G, ARG48K, ASP54K, ASP58K, ASP67G, ASP97G, CYS21K, CYS51K, GLN116K, GLN44G, GLN68G, GLU22K, GLU59G, GLU64G, GLU95G, GLY107G, GLY115K, GLY20K, GLY53K, GLY93G, GLY93K, HIS117K, HIS61G, ILE113K, ILE18K, ILE62G, ILE65G, ILE78G, ILE85G, ILE85K, ILE94G, LEU111K, LEU17K, LEU45G, LEU47G, LEU47K, LEU52K, LEU81G, LEU81K, LEU86G, LEU86K, LEU96G, LYS105G, LYS55K, LYS74G, LYS82G, LYS82K, MET88G, MET88K, MET91G, MET91K, PHE102G, PHE30K, PHE32K, PHE60G, PRO110K, PRO77G, PRO83K, PRO87G, PRO87K, SER114K, SER75G, SER84G, SER84K, THR101G, THR49K, THR80G, THR90G, THR90K, TRP19K, TYR112K, VAL100G, VAL118K, VAL50G, VAL50K, VAL63G, VAL66G, VAL76G, VAL92G, VAL92K
• H-I: ALA106I, ALA46H, ALA56H, ALA79I, ALA89H, ALA89I, ARG48H, ARG48I, ASP16H, ASP54H, ASP58H, ASP67I, ASP97I, CYS21H, CYS51H, GLN116H, GLN44I, GLN68I, GLU22H, GLU59I, GLU64I, GLU69I, GLU70I, GLU73I, GLU95I, GLY107I, GLY115H, GLY20H, GLY53H, GLY93H, GLY93I, HIS117H, HIS61I, ILE113H, ILE18H, ILE62I, ILE65I, ILE78I, ILE85H, ILE85I, ILE94I, LEU111H, LEU17H, LEU45I, LEU47H, LEU47I, LEU52H, LEU81H, LEU81I, LEU86H, LEU86I, LEU96I, LYS105I, LYS55H, LYS74I, LYS82H, LYS82I, MET88H, MET88I, MET91H, MET91I, PHE102I, PHE60I, PRO110H, PRO77I, PRO83H, PRO87H, PRO87I, SER114H, SER75I, SER84H, SER84I, THR101I, THR49H, THR49I, THR80I, THR90H, THR90I, TRP19H, TYR112H, VAL100I, VAL50H, VAL50I, VAL63I, VAL66I, VAL76I, VAL92H, VAL92I
• H-J: LEU86H, LEU86J, THR90H, VAL92H, VAL92J
• H-K: ILE85H, ILE85K, LEU86H, LEU86K, THR90H, THR90K, VAL92H, VAL92K
• I-J: ALA106J, ALA46I, ALA46J, ALA56I, ALA79J, ALA89I, ALA89J, ARG48I, ASP16I, ASP54I, ASP58I, ASP67J, ASP97J, CYS21I, CYS51I, GLN116I, GLN44J, GLN68J, GLU22I, GLU59J, GLU64J, GLU69J, GLU70J, GLU95J, GLY107J, GLY115I, GLY20I, GLY53I, GLY93I, GLY93J, HIS117I, HIS61J, ILE113I, ILE18I, ILE62J, ILE65J, ILE78J, ILE85I, ILE85J, ILE94J, LEU111I, LEU17I, LEU45J, LEU47I, LEU47J, LEU52I, LEU81I, LEU81J, LEU86I, LEU86J, LEU96J, LYS105J, LYS55I, LYS74J, LYS82I, LYS82J, MET88I, MET88J, MET91I, MET91J, PHE102J, PHE60J, PRO110I, PRO77J, PRO83I, PRO87I, PRO87J, SER114I, SER84I, SER84J, THR101J, THR49I, THR80J, THR90I, THR90J, TRP19I, TYR112I, VAL100J, VAL118I, VAL50I, VAL50J, VAL63J, VAL66J, VAL75J, VAL76J, VAL92I, VAL92J
• I-K: ILE85I, ILE85K, LEU86I, LEU86K, THR90I, VAL92I, VAL92K
• J-K: ALA106K, ALA46J, ALA56J, ALA79K, ALA89J, ALA89K, ARG48J, ARG48K, ASP54J, ASP58J, ASP67K, ASP97K, CYS21J, CYS51J, GLN116J, GLN44K, GLU22J, GLU59K, GLU64K, GLU95K, GLY107K, GLY115J, GLY20J, GLY53J, GLY93J, GLY93K, HIS61K, ILE113J, ILE18J, ILE62K, ILE65K, ILE78K, ILE85J, ILE85K, ILE94J, ILE94K, LEU111J, LEU17J, LEU45K, LEU47J, LEU47K, LEU52J, LEU81J, LEU81K, LEU86J, LEU86K, LEU96K, LYS105K, LYS55J, LYS74K, LYS82J, LYS82K, MET88J, MET88K, MET91J, MET91K, PHE102K, PHE60K, PRO110J, PRO77K, PRO83J, PRO87J, PRO87K, SER114J, SER75K, SER84J, SER84K, THR49J, THR49K, THR80K, THR90J, THR90K, TRP19J, TYR112J, VAL100K, VAL118J, VAL50J, VAL50K, VAL63K, VAL66K, VAL76K, VAL92J, VAL92K