2VPF

vascular endothelial growth factor refined to 1.93 angstroms resolution

• Total interactions analyzed: 28
• Total true interactions: 15
• Strongest Interaction:
  • Chains: F-H
  • Int. Res.: 26
  • Norm. En. per Res.: -4.128
• Hub Node: B(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-83.3663	-43.2919	567.081	440.4228	117	30	9	15518	2	18	22
A-H	0.0	0.0	-0.1255	-0.1255	2	0	0	31	0	1	3
B-E	0.0	-14.5311	-62.606	-77.1371	44	4	0	2934	2	29	16
B-G	0.0	0.0	-0.0345	-0.0345	3	0	0	8	0	1	2
B-H	-9.4802	16.0122	-74.5127	-67.9808	34	4	2	2889	0	8	14
C-D	-86.4061	-34.5597	732.608	611.6422	114	25	8	15105	1	15	17
D-E	0.0	0.0	-0.0014	-0.0014	2	0	0	1	0	1	3
D-F	-14.1023	-0.2274	-29.1021	-43.4318	24	4	0	1029	0	8	4
D-G	-11.3843	-18.982	-32.1772	-62.5436	24	1	0	1404	2	16	15
E-F	-91.411	-39.6612	629.913	498.8408	117	18	9	14941	2	20	22
E-G	-11.8631	-23.9677	-39.3827	-75.2136	20	1	0	1633	2	10	7
E-H	-29.115	-6.1201	-70.4305	-105.6656	35	3	0	2567	0	13	8
F-G	0.0	8.0992	-29.0679	-20.9687	31	0	0	1395	0	5	7
F-H	-29.5345	-28.1821	-49.6126	-107.3292	26	3	0	2162	2	10	10
G-H	-89.2957	-48.3205	311.729	174.1128	115	20	8	15542	2	18	22

Interface residues

• A-B: ARG23A, ARG23B, ARG56A, ARG82A, ARG82B, ASN62A, ASN62B, ASN75B, ASP19A, ASP19B, ASP34A, ASP34B, ASP63A, ASP63B, CYS26A, CYS26B, CYS51A, CYS51B, CYS57A, CYS57B, CYS60A, CYS60B, CYS61A, CYS61B, CYS68A, GLN22A, GLN22B, GLN79A, GLN79B, GLN89B, GLN98A, GLN98B, GLU13A, GLU13B, GLU30A, GLU30B, GLU64A, GLU64B, GLU93A, GLU93B, GLY58A, GLY58B, GLY59A, GLY59B, GLY92A, GLY92B, HIS27A, HIS27B, ILE29A, ILE29B, ILE35A, ILE35B, ILE46A, ILE46B, ILE76A, ILE76B, ILE80A, ILE80B, ILE83A, ILE83B, ILE91A, ILE91B, LEU32A, LEU32B, LEU54A, LEU54B, LYS16A, LYS16B, LYS48A, LYS48B, MET18A, MET18B, MET55A, MET55B, MET78A, MET78B, MET81A, MET81B, MET94A, MET94B, PHE17A, PHE17B, PHE36A, PHE36B, PHE47A, PHE47B, PHE96A, PHE96B, PRO28A, PRO49A, PRO49B, PRO53A, PRO53B, SER24A, SER24B, SER50A, SER50B, SER95A, SER95B, THR31A, THR31B, THR77A, THR77B, TYR21A, TYR21B, TYR25A, TYR25B, VAL14A, VAL14B, VAL15A, VAL15B, VAL20A, VAL20B, VAL33A, VAL33B, VAL52A, VAL52B
• A-H: ASP41H, VAL14A
• B-E: ARG105B, ARG56B, ARG82E, ASN100B, ASP41B, ASP41E, CYS102B, GLN37B, GLN87E, GLN89E, GLN98B, GLU103B, GLU38B, GLU38E, GLU42B, GLU42E, GLU44E, GLU67B, GLU72B, GLU73B, GLU93E, GLY88E, HIS86E, HIS99B, ILE43E, LEU97B, LYS101B, LYS108B, LYS84E, MET94E, PHE96B, PRO106B, PRO40B, PRO40E, PRO70B, PRO85E, SER95B, SER95E, THR71B, TYR39B, TYR39E, TYR45E, VAL33B, VAL69B
• B-G: ASP41B, GLU64G, LYS107G
• B-H: ARG56B, ARG82B, ASN75B, ASP41H, GLN37H, GLN87H, GLN98B, GLU38B, GLU38H, GLU42B, GLU42H, GLU44H, GLU72B, GLU73B, GLU93B, GLY92B, HIS90B, ILE43H, ILE76B, LEU97B, LYS84H, MET78B, MET94B, PHE36H, PHE96B, PRO40H, PRO85H, SER74B, SER95B, THR71B, THR77B, TYR39B, TYR39H, TYR45H
• C-D: ARG23C, ARG23D, ARG56C, ARG56D, ARG82C, ARG82D, ASN62C, ASN62D, ASN75C, ASP19C, ASP19D, ASP34C, ASP34D, ASP63C, ASP63D, CYS26C, CYS26D, CYS51C, CYS51D, CYS57C, CYS57D, CYS60C, CYS60D, CYS61C, CYS61D, CYS68D, GLN22C, GLN22D, GLN79C, GLN79D, GLN98C, GLN98D, GLU13D, GLU30C, GLU30D, GLU64C, GLU64D, GLU93C, GLU93D, GLY58C, GLY58D, GLY59C, GLY59D, GLY92C, GLY92D, HIS27C, HIS27D, ILE29C, ILE29D, ILE35C, ILE35D, ILE46C, ILE46D, ILE76C, ILE76D, ILE80C, ILE80D, ILE83C, ILE83D, ILE91C, ILE91D, LEU32C, LEU32D, LEU54C, LEU54D, LYS16C, LYS16D, LYS48C, LYS48D, MET18C, MET18D, MET55C, MET78C, MET78D, MET81C, MET81D, MET94C, MET94D, PHE17C, PHE17D, PHE47C, PHE47D, PHE96C, PHE96D, PRO28C, PRO28D, PRO49C, PRO49D, PRO53C, PRO53D, SER24C, SER24D, SER50C, SER50D, SER95C, SER95D, THR31C, THR31D, THR77C, THR77D, TYR21C, TYR21D, TYR25C, TYR25D, VAL14C, VAL14D, VAL15C, VAL15D, VAL20C, VAL20D, VAL33C, VAL33D, VAL52C, VAL52D
• D-E: GLU72D, ILE76E
• D-F: ARG23F, ASN100D, ASN75D, ASP19F, GLN22F, GLN98D, GLU13F, GLU72D, GLU73D, GLU93D, ILE76D, LEU97D, LYS16F, MET18F, MET78D, MET94D, PHE17F, PHE96D, SER74D, SER95D, THR77D, TYR21F, VAL15F, VAL20F
• D-G: ARG105G, ARG82D, ASN100G, ASN75G, ASP41D, GLN87D, GLN98G, GLU42D, GLU44D, GLU72G, GLU73G, GLU93D, GLY88D, GLY92D, HIS86D, HIS90D, ILE76G, LEU97G, LYS101G, LYS84D, MET94D, SER74G, THR71G, TYR45D
• E-F: ARG23E, ARG23F, ARG56E, ARG82E, ARG82F, ASN62E, ASN62F, ASP19E, ASP19F, ASP34E, ASP34F, ASP63E, ASP63F, CYS26E, CYS26F, CYS51E, CYS51F, CYS57E, CYS60E, CYS60F, CYS61E, CYS61F, CYS68E, CYS68F, GLN22E, GLN22F, GLN79E, GLN79F, GLN89F, GLN98E, GLN98F, GLU13E, GLU13F, GLU30E, GLU30F, GLU64E, GLU64F, GLU93E, GLU93F, GLY58E, GLY58F, GLY59E, GLY59F, GLY92E, GLY92F, HIS27E, HIS27F, ILE29E, ILE29F, ILE35E, ILE35F, ILE46E, ILE46F, ILE76E, ILE76F, ILE80E, ILE80F, ILE83E, ILE83F, ILE91E, ILE91F, LEU32E, LEU32F, LEU54E, LEU54F, LEU66F, LYS16E, LYS16F, LYS48E, LYS48F, MET18E, MET18F, MET55E, MET55F, MET78E, MET78F, MET81E, MET81F, MET94E, MET94F, PHE17E, PHE17F, PHE36E, PHE36F, PHE47E, PHE47F, PHE96E, PHE96F, PRO28E, PRO49E, PRO49F, PRO53E, PRO53F, SER24E, SER24F, SER50E, SER50F, SER95E, SER95F, THR31E, THR31F, THR77E, THR77F, TYR21E, TYR21F, TYR25E, TYR25F, VAL14E, VAL14F, VAL15E, VAL15F, VAL20E, VAL20F, VAL33E, VAL33F, VAL52E, VAL52F
• E-G: ARG105G, ASN62G, ASP63G, GLN87E, GLN89E, GLU64G, GLY65G, GLY88E, HIS86E, ILE46E, ILE83E, ILE91E, LEU66G, LYS107G, LYS48E, LYS84E, MET81E, PRO106G, PRO49E, PRO85E
• E-H: ASP34E, ASP34H, GLN37E, GLN37H, GLN87E, GLN87H, GLU42E, GLU42H, GLU44E, GLU44H, HIS86E, HIS86H, ILE35E, ILE35H, ILE43E, ILE43H, ILE46E, ILE46H, ILE83E, ILE83H, LYS48E, LYS84E, LYS84H, PHE36E, PHE36H, PHE47E, PHE47H, PRO40E, PRO40H, PRO85E, PRO85H, SER50E, SER50H, TYR45E, TYR45H
• F-G: ARG105F, ARG105G, ASN62F, ASN62G, ASP63F, ASP63G, CYS104F, CYS104G, CYS61F, CYS61G, GLN22F, GLN22G, GLU64F, GLU64G, GLY65F, GLY65G, LEU66F, LEU66G, LYS107F, LYS107G, LYS108F, MET18F, MET18G, PHE17F, PHE17G, PRO106F, PRO106G, TYR21F, TYR21G, TYR25F, TYR25G
• F-H: ARG105F, ASN62F, ASP63F, CYS104F, CYS61F, GLN87H, GLN89H, GLU64F, GLU67F, GLY65F, GLY88H, HIS86H, HIS90H, ILE46H, ILE83H, ILE91H, LEU66F, LYS107F, LYS108F, LYS48H, LYS84H, MET81H, PHE47H, PRO106F, PRO49H, PRO85H
• G-H: ARG23G, ARG23H, ARG56G, ARG82G, ARG82H, ASN62G, ASN62H, ASP19G, ASP19H, ASP34G, ASP34H, ASP63G, ASP63H, CYS26G, CYS26H, CYS51G, CYS51H, CYS57G, CYS57H, CYS60G, CYS60H, CYS61G, CYS61H, GLN22G, GLN22H, GLN79G, GLN79H, GLN89G, GLN98G, GLN98H, GLU13G, GLU30G, GLU30H, GLU64G, GLU64H, GLU93G, GLU93H, GLY58G, GLY58H, GLY59G, GLY59H, GLY92G, GLY92H, HIS27G, HIS27H, ILE29G, ILE29H, ILE35G, ILE35H, ILE46G, ILE46H, ILE76G, ILE76H, ILE80G, ILE80H, ILE83G, ILE83H, ILE91G, ILE91H, LEU32G, LEU32H, LEU54G, LEU54H, LYS16G, LYS16H, LYS48G, LYS48H, MET18G, MET18H, MET55G, MET55H, MET78G, MET78H, MET81G, MET81H, MET94G, MET94H, PHE17G, PHE17H, PHE36G, PHE36H, PHE47G, PHE47H, PHE96G, PHE96H, PRO28G, PRO49G, PRO49H, PRO53G, PRO53H, SER24G, SER24H, SER50G, SER50H, SER95G, SER95H, THR31G, THR31H, THR77G, THR77H, TYR21G, TYR21H, TYR25G, TYR25H, TYR45G, VAL14G, VAL14H, VAL15G, VAL15H, VAL20G, VAL20H, VAL33G, VAL33H, VAL52G, VAL52H