2VL0

x-ray structure of a pentameric ligand gated ion channel from erwinia chrysanthemi (elic)

• Total interactions analyzed: 45
• Total true interactions: 24
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 239
  • Norm. En. per Res.: -2.6487
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-43.0763	-14.9253	-539.884	-597.8856	236	56	17	24164	3	28	42
A-C	0.0	0.0	-0.952	-0.952	10	0	0	163	0	0	0
A-D	0.0	0.0	-1.1027	-1.1027	10	0	0	176	0	0	0
A-E	-43.1741	-8.9086	-536.969	-589.0517	237	65	18	24441	3	29	42
A-J	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
B-C	-41.3343	-6.7217	-565.239	-613.2949	239	67	20	25013	3	29	42
B-D	0.0	0.0	-1.2652	-1.2652	11	0	0	186	0	0	0
B-E	0.0	0.0	-1.4863	-1.4863	11	0	0	196	0	0	0
B-I	-8.4843	0.1896	-91.6981	-99.9928	77	19	1	5170	1	32	37
B-J	0.0	0.0	-0.0321	-0.0321	2	0	0	9	0	2	2
C-D	-39.7901	-15.8694	-545.553	-601.2125	235	54	17	24253	3	29	42
C-E	0.0	0.0	-1.1165	-1.1165	10	0	0	169	0	0	0
C-I	0.0	0.0	-0.0109	-0.0109	2	0	0	8	0	2	1
D-E	-53.1177	-8.995	-529.159	-591.2717	239	45	17	23331	3	27	41
F-G	-34.8951	-25.1343	-554.808	-614.8374	236	51	19	24218	3	30	42
F-H	0.0	0.0	-1.0177	-1.0177	10	0	0	168	0	0	0
F-I	0.0	0.0	-1.0761	-1.0761	11	0	0	171	0	0	0
F-J	-39.5232	-16.7756	-533.542	-589.8408	237	55	17	24103	3	29	42
G-H	-45.6712	-16.8053	-570.551	-633.0275	239	68	17	24842	3	29	42
G-I	0.0	0.0	-1.2637	-1.2637	10	0	0	182	0	0	0
G-J	0.0	0.0	-1.6303	-1.6303	11	0	0	208	0	0	0
H-I	-26.6852	-9.3033	-535.981	-571.9695	241	57	19	24516	3	29	43
H-J	0.0	0.0	-1.3419	-1.3419	10	0	0	184	0	0	0
I-J	-45.9051	-35.9431	-526.214	-608.0621	238	60	18	24155	3	30	42

Interface residues

• A-B: ALA104A, ALA216A, ALA217A, ALA243A, ALA243B, ALA245A, ALA245B, ALA274B, ALA75B, ARG105A, ARG117B, ARG173B, ARG189B, ARG198A, ARG230A, ARG254A, ARG254B, ARG285B, ARG298A, ARG300A, ARG65A, ARG65B, ARG91A, ARG99A, ASN103A, ASN112B, ASN136B, ASN137B, ASN154A, ASN183B, ASN199A, ASN21A, ASN250A, ASN250B, ASN27B, ASN60A, ASN68B, ASN69B, ASN80B, ASN89A, ASP113B, ASP115B, ASP144A, ASP153A, ASP158A, ASP175B, ASP262B, ASP36A, ASP86A, ASP97A, GLN124B, GLN146A, GLN181B, GLN184B, GLN232A, GLN232B, GLN263B, GLN286B, GLN31B, GLN42A, GLN62A, GLU129B, GLU131B, GLU155A, GLU156A, GLU159A, GLU225A, GLU229A, GLU229B, GLU30B, GLU59A, GLU64A, GLU64B, GLU77B, GLY108A, GLY212A, GLY25A, GLY268B, GLY270B, GLY289B, GLY37A, GLY70B, GLY83B, GLY88A, HIS176B, HIS283B, HIS284B, ILE101A, ILE145A, ILE157A, ILE214A, ILE215A, ILE251A, ILE251B, ILE265B, ILE266B, ILE272A, ILE272B, ILE276B, ILE279B, ILE280B, ILE39A, ILE57A, ILE63A, ILE63B, ILE67B, ILE79B, LEU107A, LEU118B, LEU177B, LEU204A, LEU209A, LEU211A, LEU213A, LEU224A, LEU231A, LEU231B, LEU237A, LEU237B, LEU239A, LEU239B, LEU252A, LEU252B, LEU255B, LEU277B, LEU29B, LEU314B, LEU56A, LEU71B, LEU76B, LEU92A, LYS22A, LYS34A, LYS54A, LYS90A, LYS90B, MET114B, MET238A, MET238B, MET93A, PHE106A, PHE110B, PHE116B, PHE133B, PHE187B, PHE19A, PHE207A, PHE222A, PHE227B, PHE235A, PHE235B, PHE246A, PHE246B, PHE273B, PHE281B, PHE78B, PHE95A, PRO132B, PRO182B, PRO200A, PRO210A, PRO253B, PRO256B, PRO55A, PRO74B, PRO85B, SER109B, SER111B, SER134B, SER178B, SER179B, SER17A, SER201A, SER206A, SER218A, SER220A, SER226A, SER226B, SER228A, SER228B, SER234A, SER234B, SER249A, SER249B, SER271B, SER84B, THR233A, THR233B, THR236A, THR236B, THR240A, THR240B, THR248A, THR248B, THR258B, THR259B, THR28B, THR32B, THR61A, THR87A, TRP160A, TRP161A, TRP205A, TRP219A, TRP223A, TRP66B, TRP72B, TYR102A, TYR135B, TYR148A, TYR174B, TYR202A, TYR203A, TYR244A, TYR244B, TYR247A, TYR247B, TYR24A, TYR257B, TYR269B, TYR38A, VAL100A, VAL180B, VAL221A, VAL241A, VAL241B, VAL242A, VAL242B, VAL26A, VAL290B, VAL35A, VAL40A, VAL58A, VAL73B, VAL81B, VAL82B
• A-C: ALA243A, ASN250A, ASN250C, ILE251A, LEU239A, LEU239C, PHE246A, PHE246C, THR236A, TYR247A
• A-D: ALA243D, ASN250A, ASN250D, ILE251D, LEU239A, LEU239D, PHE246A, PHE246D, THR236D, TYR247D
• A-E: ALA104E, ALA216E, ALA217E, ALA243A, ALA243E, ALA245A, ALA245E, ALA274A, ALA75A, ARG105E, ARG117A, ARG173A, ARG189A, ARG198E, ARG230A, ARG230E, ARG254A, ARG254E, ARG285A, ARG298E, ARG300E, ARG65A, ARG65E, ARG91E, ARG99E, ASN103E, ASN112A, ASN136A, ASN137A, ASN154E, ASN199E, ASN21E, ASN250A, ASN250E, ASN27A, ASN60E, ASN68A, ASN69A, ASN80A, ASN89E, ASP113A, ASP115A, ASP144E, ASP153E, ASP158E, ASP175A, ASP262A, ASP36E, ASP86E, ASP97E, GLN124A, GLN146E, GLN181A, GLN184A, GLN232A, GLN232E, GLN263A, GLN286A, GLN31A, GLN42E, GLN62E, GLU129A, GLU131A, GLU150E, GLU155E, GLU156E, GLU159E, GLU225E, GLU229A, GLU229E, GLU30A, GLU59E, GLU64A, GLU64E, GLU77A, GLY108E, GLY212E, GLY25E, GLY268A, GLY270A, GLY289A, GLY37E, GLY70A, GLY83A, GLY88E, HIS176A, HIS283A, HIS284A, ILE101E, ILE157E, ILE214E, ILE215E, ILE23E, ILE251A, ILE251E, ILE265A, ILE266A, ILE272A, ILE272E, ILE276A, ILE279A, ILE280A, ILE39E, ILE57E, ILE63A, ILE63E, ILE67A, ILE79A, LEU107E, LEU130A, LEU177A, LEU204E, LEU209E, LEU211E, LEU213E, LEU224E, LEU231A, LEU231E, LEU237A, LEU237E, LEU239A, LEU239E, LEU252A, LEU252E, LEU255A, LEU277A, LEU294E, LEU29A, LEU314A, LEU56E, LEU71A, LEU76A, LEU92E, LYS22E, LYS34E, LYS54E, LYS90A, LYS90E, MET114A, MET238A, MET238E, MET93E, PHE106E, PHE110A, PHE116A, PHE133A, PHE187A, PHE19E, PHE207E, PHE222E, PHE227A, PHE235A, PHE235E, PHE246A, PHE246E, PHE273A, PHE281A, PHE78A, PHE95E, PRO132A, PRO182A, PRO200E, PRO210E, PRO253A, PRO256A, PRO55E, PRO74A, PRO85A, SER109A, SER111A, SER134A, SER178A, SER179A, SER17E, SER201E, SER206E, SER218E, SER220E, SER226A, SER226E, SER228A, SER228E, SER234A, SER234E, SER249A, SER249E, SER271A, SER84A, THR233A, THR233E, THR236A, THR236E, THR240A, THR240E, THR248A, THR248E, THR258A, THR259A, THR28A, THR32A, THR61E, THR87E, TRP160E, TRP161E, TRP205E, TRP219E, TRP223E, TRP66A, TRP72A, TYR102E, TYR135A, TYR148E, TYR174A, TYR202E, TYR203E, TYR244A, TYR244E, TYR247A, TYR247E, TYR24E, TYR257A, TYR269A, TYR38E, VAL180A, VAL221E, VAL241A, VAL241E, VAL242A, VAL242E, VAL26E, VAL290A, VAL35E, VAL40E, VAL58E, VAL73A, VAL81A, VAL82A
• A-J: GLN181J, ILE152A
• B-C: ALA104B, ALA216B, ALA217B, ALA243B, ALA243C, ALA245B, ALA245C, ALA267C, ALA274C, ALA75C, ARG105B, ARG117C, ARG173C, ARG189C, ARG198B, ARG230B, ARG230C, ARG254B, ARG254C, ARG285C, ARG298B, ARG300B, ARG65B, ARG65C, ARG91B, ARG99B, ASN103B, ASN112C, ASN136C, ASN137C, ASN154B, ASN199B, ASN21B, ASN250B, ASN250C, ASN27C, ASN60B, ASN68C, ASN69C, ASN80C, ASN89B, ASP113C, ASP115C, ASP144B, ASP153B, ASP158B, ASP175C, ASP262C, ASP36B, ASP86B, ASP97B, GLN124C, GLN146B, GLN181C, GLN184C, GLN232B, GLN232C, GLN263C, GLN286C, GLN31C, GLN42B, GLN62B, GLU129C, GLU131C, GLU150B, GLU155B, GLU156B, GLU159B, GLU225B, GLU229B, GLU229C, GLU30C, GLU59B, GLU64B, GLU64C, GLU77C, GLY108B, GLY212B, GLY25B, GLY268C, GLY270C, GLY289C, GLY37B, GLY70C, GLY83C, GLY88B, HIS176C, HIS283C, HIS284C, ILE101B, ILE157B, ILE214B, ILE215B, ILE23B, ILE251B, ILE251C, ILE265C, ILE266C, ILE272B, ILE272C, ILE276C, ILE279C, ILE280C, ILE39B, ILE57B, ILE63B, ILE63C, ILE67C, ILE79C, LEU107B, LEU118C, LEU130C, LEU177C, LEU204B, LEU209B, LEU211B, LEU213B, LEU224B, LEU231B, LEU231C, LEU237B, LEU237C, LEU239B, LEU239C, LEU252B, LEU252C, LEU255C, LEU277C, LEU29C, LEU314C, LEU56B, LEU71C, LEU76C, LEU92B, LYS22B, LYS34B, LYS54B, LYS90B, LYS90C, MET114C, MET238B, MET238C, MET93B, PHE106B, PHE110C, PHE116C, PHE133C, PHE187C, PHE19B, PHE207B, PHE222B, PHE227C, PHE235B, PHE235C, PHE246B, PHE246C, PHE273C, PHE281C, PHE78C, PHE95B, PRO132C, PRO182C, PRO200B, PRO210B, PRO253C, PRO256C, PRO55B, PRO74C, PRO85C, SER109C, SER111C, SER134C, SER15B, SER178C, SER179C, SER17B, SER201B, SER206B, SER218B, SER220B, SER226B, SER226C, SER228B, SER228C, SER234B, SER234C, SER249B, SER249C, SER271C, SER84C, THR233B, THR233C, THR236B, THR236C, THR240B, THR240C, THR248B, THR248C, THR258C, THR259C, THR28C, THR32C, THR61B, THR87B, TRP160B, TRP161B, TRP205B, TRP219B, TRP223B, TRP66C, TRP72C, TYR102B, TYR135C, TYR148B, TYR174C, TYR202B, TYR203B, TYR244B, TYR244C, TYR247B, TYR247C, TYR24B, TYR257C, TYR269C, TYR38B, VAL180C, VAL221B, VAL241B, VAL241C, VAL242B, VAL242C, VAL26B, VAL290C, VAL35B, VAL40B, VAL58B, VAL73C, VAL81C, VAL82C
• B-D: ALA243B, ASN250B, ASN250D, ILE251B, LEU239B, LEU239D, PHE246B, PHE246D, THR236B, THR236D, TYR247B
• B-E: ALA243E, ASN250B, ASN250E, ILE251E, LEU239B, LEU239E, PHE246B, PHE246E, THR236B, THR236E, TYR247E
• B-I: ALA165B, ALA165I, ARG123B, ARG123I, ARG141B, ARG141I, ARG163B, ARG163I, ARG173B, ARG173I, ARG189B, ARG193B, ARG193I, ASN137I, ASN151B, ASN151I, ASN183B, ASN183I, ASP13I, ASP144B, ASP144I, ASP153I, ASP171B, ASP171I, ASP175B, ASP195B, ASP195I, GLN125B, GLN139B, GLN139I, GLU150I, GLU155B, GLU155I, GLU186B, GLU186I, HIS168B, HIS168I, ILE145B, ILE145I, ILE152B, ILE152I, ILE162B, ILE162I, ILE169B, ILE169I, ILE172B, ILE190B, ILE190I, ILE194B, LEU140B, LEU140I, LYS164B, LYS164I, PHE142B, PHE142I, PRO11B, PRO11I, SER143B, SER143I, SER166B, SER166I, SER170B, SER170I, SER188B, SER188I, THR149B, THR149I, THR167B, THR167I, THR191B, THR191I, TYR148B, TYR148I, VAL12I, VAL147B, VAL192I, VAL197I
• B-J: ARG173J, ILE316B
• C-D: ALA104C, ALA216C, ALA217C, ALA243C, ALA243D, ALA245C, ALA245D, ALA274D, ALA75D, ARG105C, ARG117D, ARG173D, ARG189D, ARG198C, ARG230C, ARG254C, ARG254D, ARG285D, ARG298C, ARG300C, ARG65C, ARG65D, ARG91C, ARG99C, ASN103C, ASN112D, ASN136D, ASN137D, ASN154C, ASN199C, ASN21C, ASN250C, ASN250D, ASN27D, ASN60C, ASN68D, ASN69D, ASN80D, ASN89C, ASP113D, ASP115D, ASP144C, ASP153C, ASP158C, ASP175D, ASP262D, ASP36C, ASP86C, ASP97C, GLN124D, GLN146C, GLN181D, GLN184D, GLN232C, GLN232D, GLN263D, GLN286D, GLN31D, GLN42C, GLN62C, GLU129D, GLU131D, GLU150C, GLU155C, GLU156C, GLU159C, GLU225C, GLU229C, GLU229D, GLU30D, GLU59C, GLU64C, GLU64D, GLU77D, GLY108C, GLY212C, GLY25C, GLY268D, GLY270D, GLY289D, GLY37C, GLY70D, GLY83D, GLY88C, HIS176D, HIS283D, HIS284D, ILE101C, ILE157C, ILE214C, ILE215C, ILE251C, ILE251D, ILE265D, ILE266D, ILE272C, ILE272D, ILE276D, ILE279D, ILE280D, ILE39C, ILE57C, ILE63C, ILE63D, ILE67D, ILE79D, LEU107C, LEU118D, LEU130D, LEU177D, LEU204C, LEU209C, LEU211C, LEU213C, LEU224C, LEU231C, LEU231D, LEU237C, LEU237D, LEU239C, LEU239D, LEU252C, LEU252D, LEU255D, LEU277D, LEU29D, LEU314D, LEU56C, LEU71D, LEU76D, LEU92C, LYS22C, LYS34C, LYS54C, LYS90C, LYS90D, MET114D, MET238C, MET238D, MET93C, PHE106C, PHE110D, PHE116D, PHE133D, PHE187D, PHE19C, PHE207C, PHE222C, PHE227D, PHE235C, PHE235D, PHE246C, PHE246D, PHE273D, PHE281D, PHE78D, PHE95C, PRO132D, PRO182D, PRO200C, PRO210C, PRO253D, PRO256D, PRO55C, PRO74D, PRO85D, SER109D, SER111D, SER134D, SER178D, SER179D, SER17C, SER201C, SER206C, SER218C, SER220C, SER226C, SER226D, SER228C, SER228D, SER234C, SER234D, SER249C, SER249D, SER271D, SER84D, THR233C, THR233D, THR236C, THR236D, THR240C, THR240D, THR248C, THR248D, THR258D, THR259D, THR28D, THR32D, THR61C, THR87C, TRP160C, TRP161C, TRP205C, TRP219C, TRP223C, TRP66D, TRP72D, TYR102C, TYR135D, TYR148C, TYR174D, TYR202C, TYR203C, TYR244C, TYR244D, TYR247C, TYR247D, TYR24C, TYR257D, TYR269D, TYR38C, VAL180D, VAL221C, VAL241C, VAL241D, VAL242C, VAL242D, VAL26C, VAL290D, VAL35C, VAL40C, VAL58C, VAL73D, VAL81D, VAL82D
• C-E: ALA243C, ASN250C, ASN250E, ILE251C, LEU239C, LEU239E, PHE246C, PHE246E, THR236C, TYR247C
• C-I: ARG123I, HIS176C
• D-E: ALA104D, ALA216D, ALA217D, ALA243D, ALA243E, ALA245D, ALA245E, ALA274E, ALA75E, ARG105D, ARG117E, ARG173E, ARG189E, ARG198D, ARG230D, ARG254D, ARG254E, ARG285E, ARG298D, ARG300D, ARG65D, ARG65E, ARG91D, ARG99D, ASN103D, ASN112E, ASN136E, ASN137E, ASN154D, ASN183E, ASN199D, ASN21D, ASN250D, ASN250E, ASN27E, ASN60D, ASN68E, ASN69E, ASN80E, ASN89D, ASP113E, ASP115E, ASP144D, ASP153D, ASP158D, ASP175E, ASP262E, ASP36D, ASP86D, ASP97D, GLN124E, GLN146D, GLN181E, GLN184E, GLN232D, GLN232E, GLN263E, GLN286E, GLN31E, GLN42D, GLN62D, GLU129E, GLU131E, GLU150D, GLU155D, GLU156D, GLU159D, GLU225D, GLU229D, GLU229E, GLU30E, GLU59D, GLU64D, GLU64E, GLU77E, GLY108D, GLY212D, GLY25D, GLY268E, GLY270E, GLY289E, GLY37D, GLY70E, GLY83E, GLY88D, HIS176E, HIS283E, HIS284E, ILE101D, ILE145D, ILE157D, ILE214D, ILE215D, ILE251D, ILE251E, ILE265E, ILE266E, ILE272D, ILE272E, ILE276E, ILE279E, ILE280E, ILE39D, ILE57D, ILE63D, ILE63E, ILE67E, ILE79E, LEU107D, LEU118E, LEU130E, LEU177E, LEU204D, LEU209D, LEU211D, LEU213D, LEU224D, LEU231D, LEU231E, LEU237D, LEU237E, LEU239D, LEU239E, LEU252D, LEU252E, LEU255E, LEU277E, LEU29E, LEU314E, LEU56D, LEU71E, LEU76E, LEU92D, LYS22D, LYS34D, LYS54D, LYS90D, LYS90E, MET114E, MET238D, MET238E, MET93D, PHE106D, PHE110E, PHE116E, PHE133E, PHE187E, PHE19D, PHE207D, PHE222D, PHE227E, PHE235D, PHE235E, PHE246D, PHE246E, PHE273E, PHE281E, PHE78E, PHE95D, PRO132E, PRO182E, PRO200D, PRO210D, PRO253E, PRO256E, PRO55D, PRO74E, PRO85E, SER109E, SER111E, SER134E, SER15D, SER178E, SER179E, SER17D, SER201D, SER206D, SER218D, SER220D, SER226D, SER226E, SER228D, SER228E, SER234D, SER234E, SER249D, SER249E, SER271E, SER84E, THR233D, THR233E, THR236D, THR236E, THR240D, THR240E, THR248D, THR248E, THR258E, THR259E, THR28E, THR32E, THR61D, THR87D, TRP160D, TRP161D, TRP205D, TRP219D, TRP223D, TRP66E, TRP72E, TYR102D, TYR135E, TYR148D, TYR174E, TYR202D, TYR203D, TYR244D, TYR244E, TYR247D, TYR247E, TYR24D, TYR257E, TYR269E, TYR38D, VAL100D, VAL180E, VAL221D, VAL241D, VAL241E, VAL242D, VAL242E, VAL26D, VAL290E, VAL35D, VAL40D, VAL58D, VAL73E, VAL81E, VAL82E
• F-G: ALA104F, ALA216F, ALA217F, ALA243F, ALA243G, ALA245F, ALA245G, ALA274G, ALA75G, ARG105F, ARG117G, ARG173G, ARG189G, ARG198F, ARG230F, ARG230G, ARG254F, ARG254G, ARG285G, ARG298F, ARG300F, ARG65F, ARG65G, ARG91F, ARG99F, ASN103F, ASN112G, ASN136G, ASN137G, ASN154F, ASN199F, ASN21F, ASN250F, ASN250G, ASN27G, ASN60F, ASN68G, ASN69G, ASN80G, ASN89F, ASP113G, ASP115G, ASP144F, ASP153F, ASP158F, ASP175G, ASP262G, ASP36F, ASP86F, ASP97F, GLN124G, GLN146F, GLN181G, GLN184G, GLN232F, GLN232G, GLN263G, GLN286G, GLN31G, GLN42F, GLN62F, GLU129G, GLU131G, GLU150F, GLU155F, GLU156F, GLU159F, GLU225F, GLU229F, GLU229G, GLU30G, GLU59F, GLU64F, GLU64G, GLU77G, GLY108F, GLY212F, GLY25F, GLY268G, GLY270G, GLY289G, GLY37F, GLY70G, GLY83G, GLY88F, HIS176G, HIS283G, HIS284G, ILE101F, ILE157F, ILE214F, ILE215F, ILE251F, ILE251G, ILE265G, ILE266G, ILE272F, ILE272G, ILE276G, ILE279G, ILE280G, ILE39F, ILE57F, ILE63F, ILE63G, ILE67G, ILE79G, LEU107F, LEU118G, LEU177G, LEU204F, LEU209F, LEU211F, LEU213F, LEU224F, LEU231F, LEU231G, LEU237F, LEU237G, LEU239F, LEU239G, LEU252F, LEU252G, LEU255G, LEU277G, LEU29G, LEU314G, LEU56F, LEU71G, LEU76G, LEU92F, LYS22F, LYS34F, LYS54F, LYS90F, LYS90G, MET114G, MET238F, MET238G, MET93F, PHE106F, PHE110G, PHE116G, PHE133G, PHE187G, PHE19F, PHE207F, PHE222F, PHE227G, PHE235F, PHE235G, PHE246F, PHE246G, PHE273G, PHE281G, PHE78G, PHE95F, PRO132G, PRO182G, PRO200F, PRO210F, PRO253G, PRO256G, PRO55F, PRO74G, PRO85G, SER109G, SER111G, SER134G, SER178G, SER179G, SER17F, SER201F, SER206F, SER218F, SER220F, SER226F, SER226G, SER228F, SER228G, SER234F, SER234G, SER249F, SER249G, SER271G, SER84G, THR149F, THR233F, THR233G, THR236F, THR236G, THR240F, THR240G, THR248F, THR248G, THR258G, THR259G, THR28G, THR32G, THR61F, THR87F, TRP160F, TRP161F, TRP205F, TRP219F, TRP223F, TRP66G, TRP72G, TYR102F, TYR135G, TYR148F, TYR174G, TYR202F, TYR203F, TYR244F, TYR244G, TYR247F, TYR247G, TYR24F, TYR257G, TYR269G, TYR38F, VAL180G, VAL221F, VAL241F, VAL241G, VAL242F, VAL242G, VAL26F, VAL290G, VAL35F, VAL40F, VAL58F, VAL73G, VAL81G, VAL82G
• F-H: ALA243F, ASN250F, ASN250H, ILE251F, LEU239F, LEU239H, PHE246F, PHE246H, THR236F, TYR247F
• F-I: ALA243I, ASN250F, ASN250I, ILE251I, LEU239F, LEU239I, PHE246F, PHE246I, THR236I, THR240I, TYR247I
• F-J: ALA104J, ALA216J, ALA217J, ALA243F, ALA243J, ALA245F, ALA245J, ALA274F, ALA75F, ARG105J, ARG117F, ARG173F, ARG189F, ARG198J, ARG230J, ARG254F, ARG254J, ARG285F, ARG298J, ARG300J, ARG65F, ARG65J, ARG91J, ARG99J, ASN103J, ASN112F, ASN136F, ASN137F, ASN154J, ASN199J, ASN21J, ASN250F, ASN250J, ASN27F, ASN60J, ASN68F, ASN69F, ASN80F, ASN89J, ASP113F, ASP115F, ASP144J, ASP153J, ASP158J, ASP175F, ASP262F, ASP36J, ASP86J, ASP97J, GLN124F, GLN138F, GLN146J, GLN181F, GLN184F, GLN232F, GLN232J, GLN263F, GLN286F, GLN31F, GLN42J, GLN62J, GLU129F, GLU131F, GLU150J, GLU155J, GLU156J, GLU159J, GLU225J, GLU229F, GLU229J, GLU30F, GLU59J, GLU64F, GLU64J, GLU77F, GLY108J, GLY212J, GLY25J, GLY268F, GLY270F, GLY289F, GLY37J, GLY70F, GLY83F, GLY88J, HIS176F, HIS283F, HIS284F, ILE101J, ILE157J, ILE214J, ILE215J, ILE23J, ILE251F, ILE251J, ILE265F, ILE266F, ILE272F, ILE272J, ILE276F, ILE279F, ILE280F, ILE39J, ILE57J, ILE63F, ILE63J, ILE67F, ILE79F, LEU107J, LEU118F, LEU130F, LEU177F, LEU204J, LEU209J, LEU211J, LEU213J, LEU224J, LEU231F, LEU231J, LEU237F, LEU237J, LEU239F, LEU239J, LEU252F, LEU252J, LEU255F, LEU277F, LEU29F, LEU314F, LEU56J, LEU71F, LEU76F, LEU92J, LYS22J, LYS34J, LYS54J, LYS90F, LYS90J, MET114F, MET238F, MET238J, MET93J, PHE106J, PHE110F, PHE116F, PHE133F, PHE187F, PHE19J, PHE207J, PHE222J, PHE227F, PHE235F, PHE235J, PHE246F, PHE246J, PHE273F, PHE281F, PHE78F, PHE95J, PRO132F, PRO182F, PRO200J, PRO210J, PRO253F, PRO256F, PRO55J, PRO74F, PRO85F, SER109F, SER111F, SER134F, SER178F, SER179F, SER17J, SER201J, SER206J, SER218J, SER220J, SER226F, SER226J, SER228F, SER228J, SER234F, SER234J, SER249F, SER249J, SER271F, SER84F, THR233F, THR233J, THR236F, THR236J, THR240F, THR240J, THR248F, THR248J, THR258F, THR259F, THR28F, THR32F, THR61J, THR87J, TRP160J, TRP161J, TRP205J, TRP219J, TRP223J, TRP66F, TRP72F, TYR102J, TYR135F, TYR148J, TYR174F, TYR202J, TYR203J, TYR244F, TYR244J, TYR247F, TYR247J, TYR24J, TYR257F, TYR269F, TYR38J, VAL180F, VAL221J, VAL241F, VAL241J, VAL242F, VAL242J, VAL26J, VAL290F, VAL35J, VAL40J, VAL58J, VAL73F, VAL81F, VAL82F
• G-H: ALA104G, ALA216G, ALA217G, ALA243G, ALA243H, ALA245G, ALA245H, ALA274H, ALA75H, ARG105G, ARG117H, ARG173H, ARG189H, ARG198G, ARG230G, ARG230H, ARG254G, ARG254H, ARG285H, ARG298G, ARG300G, ARG65G, ARG65H, ARG91G, ARG99G, ASN103G, ASN112H, ASN136H, ASN137H, ASN154G, ASN199G, ASN21G, ASN250G, ASN250H, ASN27H, ASN60G, ASN68H, ASN69H, ASN80H, ASN89G, ASP113H, ASP115H, ASP144G, ASP153G, ASP158G, ASP175H, ASP262H, ASP36G, ASP86G, ASP97G, GLN124H, GLN146G, GLN181H, GLN184H, GLN232G, GLN232H, GLN263H, GLN286H, GLN31H, GLN42G, GLN62G, GLU129H, GLU131H, GLU150G, GLU155G, GLU156G, GLU159G, GLU225G, GLU229G, GLU229H, GLU30H, GLU59G, GLU64G, GLU64H, GLU77H, GLY108G, GLY212G, GLY25G, GLY268H, GLY270H, GLY289H, GLY37G, GLY70H, GLY83H, GLY88G, HIS176H, HIS283H, HIS284H, ILE101G, ILE145G, ILE157G, ILE214G, ILE215G, ILE23G, ILE251G, ILE251H, ILE261H, ILE265H, ILE266H, ILE272G, ILE272H, ILE276H, ILE279H, ILE280H, ILE39G, ILE57G, ILE63G, ILE63H, ILE67H, ILE79H, LEU107G, LEU118H, LEU130H, LEU177H, LEU204G, LEU209G, LEU211G, LEU213G, LEU224G, LEU231G, LEU231H, LEU237G, LEU237H, LEU239G, LEU239H, LEU252G, LEU252H, LEU255H, LEU277H, LEU29H, LEU314H, LEU56G, LEU71H, LEU76H, LEU92G, LYS22G, LYS34G, LYS54G, LYS90G, LYS90H, MET114H, MET238G, MET238H, MET93G, PHE106G, PHE110H, PHE116H, PHE133H, PHE187H, PHE19G, PHE207G, PHE222G, PHE227H, PHE235G, PHE235H, PHE246G, PHE246H, PHE273H, PHE281H, PHE78H, PHE95G, PRO132H, PRO182H, PRO200G, PRO210G, PRO253H, PRO256H, PRO55G, PRO74H, PRO85H, SER109H, SER111H, SER134H, SER178H, SER179H, SER17G, SER201G, SER206G, SER218G, SER220G, SER226G, SER226H, SER228G, SER228H, SER234G, SER234H, SER249G, SER249H, SER271H, SER84H, THR233G, THR233H, THR236G, THR236H, THR240G, THR240H, THR248G, THR248H, THR258H, THR259H, THR28H, THR32H, THR61G, THR87G, TRP160G, TRP161G, TRP205G, TRP219G, TRP223G, TRP66H, TRP72H, TYR102G, TYR135H, TYR148G, TYR174H, TYR202G, TYR203G, TYR244G, TYR244H, TYR247G, TYR247H, TYR24G, TYR257H, TYR269H, TYR38G, VAL180H, VAL221G, VAL241G, VAL241H, VAL242G, VAL242H, VAL26G, VAL290H, VAL35G, VAL40G, VAL58G, VAL73H, VAL81H, VAL82H
• G-I: ALA243G, ASN250G, ASN250I, ILE251G, LEU239G, LEU239I, PHE246G, PHE246I, THR236G, TYR247G
• G-J: ALA243J, ASN250G, ASN250J, ILE251J, LEU239G, LEU239J, PHE246G, PHE246J, THR236J, THR240J, TYR247J
• H-I: ALA104H, ALA216H, ALA217H, ALA243H, ALA243I, ALA245H, ALA245I, ALA274I, ALA75I, ARG105H, ARG117I, ARG173I, ARG189I, ARG198H, ARG230H, ARG230I, ARG254H, ARG254I, ARG285I, ARG298H, ARG300H, ARG65H, ARG65I, ARG91H, ARG99H, ASN103H, ASN112I, ASN136I, ASN137I, ASN154H, ASN199H, ASN21H, ASN250H, ASN250I, ASN27I, ASN60H, ASN68I, ASN69I, ASN80I, ASN89H, ASP113I, ASP115I, ASP144H, ASP153H, ASP158H, ASP175I, ASP262I, ASP36H, ASP86H, ASP97H, GLN124I, GLN138I, GLN146H, GLN181I, GLN184I, GLN232H, GLN232I, GLN263I, GLN286I, GLN31I, GLN42H, GLN62H, GLU129I, GLU131I, GLU150H, GLU155H, GLU156H, GLU159H, GLU225H, GLU229H, GLU229I, GLU30I, GLU59H, GLU64H, GLU64I, GLU77I, GLY108H, GLY212H, GLY25H, GLY268I, GLY270I, GLY289I, GLY37H, GLY70I, GLY83I, GLY88H, HIS176I, HIS283I, HIS284I, ILE101H, ILE157H, ILE214H, ILE215H, ILE251H, ILE251I, ILE261I, ILE265I, ILE266I, ILE272H, ILE272I, ILE276I, ILE279I, ILE280I, ILE39H, ILE57H, ILE63H, ILE63I, ILE67I, ILE79I, LEU107H, LEU118I, LEU130I, LEU177I, LEU204H, LEU209H, LEU211H, LEU213H, LEU224H, LEU231H, LEU231I, LEU237H, LEU237I, LEU239H, LEU239I, LEU252H, LEU252I, LEU255I, LEU277I, LEU29I, LEU314I, LEU56H, LEU71I, LEU76I, LEU92H, LYS22H, LYS34H, LYS54H, LYS90H, LYS90I, MET114I, MET238H, MET238I, MET93H, PHE106H, PHE110I, PHE116I, PHE133I, PHE187I, PHE19H, PHE207H, PHE222H, PHE227I, PHE235H, PHE235I, PHE246H, PHE246I, PHE273I, PHE281I, PHE78I, PHE95H, PRO132I, PRO182I, PRO200H, PRO210H, PRO253I, PRO256I, PRO55H, PRO74I, PRO85I, SER109I, SER111I, SER134I, SER178I, SER179I, SER17H, SER201H, SER206H, SER218H, SER220H, SER226H, SER226I, SER228H, SER228I, SER234H, SER234I, SER249H, SER249I, SER271I, SER84I, THR149H, THR233H, THR233I, THR236H, THR236I, THR240H, THR240I, THR248H, THR248I, THR258I, THR259I, THR28I, THR32I, THR44H, THR61H, THR87H, TRP160H, TRP161H, TRP205H, TRP219H, TRP223H, TRP66I, TRP72I, TYR102H, TYR135I, TYR148H, TYR174I, TYR202H, TYR203H, TYR244H, TYR244I, TYR247H, TYR247I, TYR24H, TYR257I, TYR269I, TYR38H, VAL100H, VAL180I, VAL221H, VAL241H, VAL241I, VAL242H, VAL242I, VAL26H, VAL290I, VAL35H, VAL40H, VAL58H, VAL73I, VAL81I, VAL82I
• H-J: ALA243H, ASN250H, ASN250J, ILE251H, LEU239H, LEU239J, PHE246H, PHE246J, THR236H, TYR247H
• I-J: ALA104I, ALA216I, ALA217I, ALA243I, ALA243J, ALA245I, ALA245J, ALA274J, ALA75J, ARG105I, ARG117J, ARG173J, ARG189J, ARG198I, ARG230I, ARG230J, ARG254I, ARG254J, ARG285J, ARG298I, ARG300I, ARG65I, ARG65J, ARG91I, ARG99I, ASN103I, ASN112J, ASN136J, ASN137J, ASN154I, ASN199I, ASN21I, ASN250I, ASN250J, ASN27J, ASN60I, ASN68J, ASN69J, ASN80J, ASN89I, ASP113J, ASP115J, ASP144I, ASP153I, ASP158I, ASP175J, ASP262J, ASP36I, ASP86I, ASP97I, GLN124J, GLN138J, GLN146I, GLN181J, GLN184J, GLN232I, GLN232J, GLN263J, GLN286J, GLN31J, GLN42I, GLN62I, GLU129J, GLU131J, GLU150I, GLU155I, GLU156I, GLU159I, GLU225I, GLU229I, GLU229J, GLU30J, GLU59I, GLU64I, GLU64J, GLU77J, GLY108I, GLY212I, GLY25I, GLY268J, GLY270J, GLY289J, GLY37I, GLY70J, GLY83J, GLY88I, HIS176J, HIS283J, HIS284J, ILE101I, ILE157I, ILE214I, ILE215I, ILE251I, ILE251J, ILE265J, ILE266J, ILE272I, ILE272J, ILE276J, ILE279J, ILE280J, ILE39I, ILE57I, ILE63I, ILE63J, ILE67J, ILE79J, LEU107I, LEU177J, LEU204I, LEU209I, LEU211I, LEU213I, LEU224I, LEU231I, LEU231J, LEU237I, LEU237J, LEU239I, LEU239J, LEU252I, LEU252J, LEU255J, LEU277J, LEU29J, LEU314J, LEU56I, LEU71J, LEU76J, LEU92I, LEU94I, LYS22I, LYS34I, LYS54I, LYS90I, LYS90J, MET114J, MET238I, MET238J, MET93I, PHE106I, PHE110J, PHE116J, PHE133J, PHE187J, PHE19I, PHE207I, PHE222I, PHE227J, PHE235I, PHE235J, PHE246I, PHE246J, PHE273J, PHE281J, PHE78J, PHE95I, PRO132J, PRO182J, PRO200I, PRO210I, PRO253J, PRO256J, PRO55I, PRO74J, PRO85J, SER109J, SER111J, SER134J, SER178J, SER179J, SER17I, SER201I, SER206I, SER218I, SER220I, SER226I, SER226J, SER228I, SER228J, SER234I, SER234J, SER249I, SER249J, SER271J, SER84J, THR233I, THR233J, THR236I, THR236J, THR240I, THR240J, THR248I, THR248J, THR258J, THR259J, THR28J, THR32J, THR61I, THR87I, TRP160I, TRP161I, TRP205I, TRP219I, TRP223I, TRP43I, TRP66J, TRP72J, TYR102I, TYR135J, TYR148I, TYR174J, TYR202I, TYR203I, TYR244I, TYR244J, TYR247I, TYR247J, TYR24I, TYR257J, TYR269J, TYR38I, VAL100I, VAL180J, VAL221I, VAL241I, VAL241J, VAL242I, VAL242J, VAL26I, VAL290J, VAL35I, VAL40I, VAL58I, VAL73J, VAL81J, VAL82J