2VI5

lumazine synthase from mycobacterium tuberculosis bound to n-6-(ribitylamino)pyrimidine-2,4(1h,3h)-dione-5-yl- propionamide

• Total interactions analyzed: 45
• Total true interactions: 35
• Strongest Interaction:
  • Chains: A-H
  • Int. Res.: 11
  • Norm. En. per Res.: -7.4775
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-19.8451	-15.2921	-313.068	-348.2052	115	14	9	12925	3	19	19
A-C	0.0	0.0	-0.0202	-0.0202	5	0	0	14	0	0	5
A-D	0.0	0.0	-0.0104	-0.0104	5	0	0	10	0	0	5
A-E	-18.6099	-16.7156	-282.274	-317.5995	112	8	7	12155	3	18	19
A-H	-6.3563	-54.6284	-21.2676	-82.2523	11	4	0	702	6	4	2
A-I	-19.4002	7.6399	-138.091	-149.8513	67	10	4	5605	7	32	30
A-J	0.0	0.0	-27.586	-27.586	16	2	2	1130	0	4	9
B-C	-15.5134	-15.972	-290.682	-322.1674	111	15	8	12377	3	19	19
B-D	0.0	0.0	-0.0085	-0.0085	5	0	0	9	0	0	5
B-E	0.0	0.0	-0.0081	-0.0081	5	0	0	7	0	0	5
B-G	0.0	-28.1455	-24.1679	-52.3134	13	1	0	697	2	4	3
B-H	-37.2682	-7.3486	-148.13	-192.7467	78	11	3	5873	8	32	31
B-I	0.0	-4.8382	-30.861	-35.6992	16	2	2	1243	0	4	9
C-D	-14.0162	-20.3526	-288.056	-322.4248	109	7	7	12020	3	19	18
C-E	0.0	0.0	-0.0112	-0.0112	5	0	0	11	0	0	5
C-F	-8.4303	-53.8422	-21.1791	-83.4516	12	3	0	683	6	4	3
C-G	-31.0504	-1.1294	-146.846	-179.0258	75	8	4	5805	7	32	31
C-H	0.0	-8.5661	-34.7054	-43.2715	16	1	2	1363	0	4	9
D-E	-19.3306	-23.8094	-287.369	-330.509	113	8	7	12108	3	19	18
D-F	-29.9063	12.2161	-139.506	-157.1962	75	17	4	5857	6	32	31
D-G	0.0	-4.722	-29.1792	-33.9012	16	2	2	1224	0	4	9
D-J	0.0	-18.8003	-19.6464	-38.4467	12	0	0	665	2	4	2
E-F	0.0	-3.2493	-33.2528	-36.5021	16	1	2	1263	0	4	9
E-I	-3.8753	-29.3273	-21.3316	-54.5343	12	0	0	654	2	4	2
E-J	-35.5319	5.3058	-134.016	-164.2421	73	16	3	5574	7	32	31
F-G	-15.1764	-16.1928	-279.013	-310.3823	110	8	7	12071	3	19	18
F-H	0.0	0.0	-0.016	-0.016	4	0	0	11	0	0	5
F-I	0.0	0.0	-0.0078	-0.0078	5	0	0	8	0	0	5
F-J	-16.454	-13.6137	-312.485	-342.5527	114	16	8	12740	3	19	19
G-H	-23.5012	-18.8597	-311.608	-353.9689	111	17	7	12645	3	19	19
G-I	0.0	0.0	-0.0258	-0.0258	5	0	0	23	0	0	5
G-J	0.0	0.0	-0.0041	-0.0041	5	0	0	6	0	0	5
H-I	-12.5034	-17.8834	-285.984	-316.3708	112	10	7	12013	3	18	17
H-J	0.0	0.0	-0.0102	-0.0102	5	0	0	10	0	0	5
I-J	-14.2699	-15.7309	-292.743	-322.7437	113	11	7	12214	3	19	17

Interface residues

• A-B: ALA113B, ALA125B, ALA135B, ALA140B, ALA142B, ALA145B, ALA146B, ALA148B, ALA150B, ALA158B, ALA21A, ALA59A, ALA66A, ALA70A, ALA75B, ALA78B, ALA96A, ALA96B, ARG103A, ARG103B, ARG128B, ARG154B, ARG157B, ARG55A, ARG71A, ARG84B, ASN114B, ASN120B, ASN72A, ASP107A, ASP107B, ASP127B, ASP137B, ASP74B, ASP91A, ASP91B, ASP95A, ASP95B, CYS94A, CYS94B, GLN124B, GLN141B, GLN67A, GLN86A, GLN99A, GLN99B, GLU123B, GLU136B, GLU155B, GLU61A, GLU68A, GLY100A, GLY100B, GLY115B, GLY58A, GLY85A, HIS73A, HIS89A, ILE112B, ILE60A, ILE62A, ILE83B, LEU101A, LEU101B, LEU106B, LEU117B, LEU147B, LEU153B, LEU156B, LEU57A, LEU69A, LYS138B, PHE90A, PHE90B, PRO111B, PRO63A, PRO88A, PRO88B, SER105A, SER105B, SER108B, SER109B, SER26A, THR102A, THR102B, THR110B, THR118B, THR119B, THR121B, THR143B, THR149B, THR152B, THR52A, THR87A, THR98A, THR98B, TRP27A, TYR92A, TYR92B, VAL104A, VAL104B, VAL116B, VAL144B, VAL23A, VAL42B, VAL53A, VAL54A, VAL56A, VAL64A, VAL65A, VAL82B, VAL93A, VAL93B, VAL97A, VAL97B
• A-C: ARG103A, GLN99A, GLN99C, LEU106C, THR102C
• A-D: ARG103D, GLN99A, GLN99D, LEU106A, THR102A
• A-E: ALA113A, ALA125A, ALA135A, ALA140A, ALA142A, ALA145A, ALA146A, ALA148A, ALA150A, ALA158A, ALA21E, ALA66E, ALA70E, ALA75A, ALA78A, ALA96A, ALA96E, ARG103A, ARG103E, ARG128A, ARG154A, ARG157A, ARG55E, ARG71E, ARG84A, ASN114A, ASN120A, ASN72E, ASP107A, ASP107E, ASP127A, ASP137A, ASP74A, ASP91A, ASP91E, ASP95A, ASP95E, CYS94A, CYS94E, GLN124A, GLN141A, GLN67E, GLN86E, GLN99A, GLN99E, GLU136A, GLU155A, GLU61E, GLU68E, GLY100A, GLY100E, GLY115A, GLY58E, GLY85E, HIS73E, HIS89E, ILE112A, ILE60E, ILE62E, ILE83A, LEU101A, LEU101E, LEU106A, LEU117A, LEU147A, LEU153A, LEU156A, LEU57E, LEU69E, LYS138A, PHE90A, PHE90E, PRO111A, PRO11A, PRO63E, PRO88E, SER105A, SER105E, SER108A, SER109A, SER12A, THR102A, THR102E, THR110A, THR118A, THR119A, THR121A, THR143A, THR149A, THR152A, THR52E, THR87E, THR98A, THR98E, TRP27E, TYR92A, TYR92E, VAL104A, VAL104E, VAL116A, VAL144A, VAL23E, VAL53E, VAL54E, VAL56E, VAL64E, VAL65E, VAL82A, VAL93A, VAL93E, VAL97A, VAL97E
• A-H: ARG71A, ARG71H, ASN72A, ASN72H, GLN67A, GLN67H, GLU68A, GLU68H, LEU69A, VAL64A, VAL64H
• A-I: ALA150A, ALA150I, ALA158A, ALA158I, ALA21A, ALA21I, ALA70A, ALA70I, ALA75A, ALA75I, ARG154A, ARG154I, ARG157A, ARG157I, ARG19A, ARG19I, ARG40A, ARG40I, ARG55I, ARG71A, ARG71I, ASN72A, ASN72I, ASP107A, ASP107I, ASP50A, ASP50I, ASP74A, ASP74I, GLU155A, GLU155I, GLU68A, GLU68I, GLY17A, GLY17I, HIS159A, HIS159I, HIS73A, HIS73I, ILE22I, LEU106I, LEU153A, LEU153I, LEU156A, LEU156I, LEU20A, LEU69A, LEU69I, PRO51A, PRO51I, SER108A, SER108I, SER109A, SER109I, SER160A, SER160I, THR110I, THR52A, THR52I, VAL18A, VAL18I, VAL53A, VAL53I, VAL54A, VAL54I, VAL65A, VAL65I
• A-J: ALA158A, ALA158J, ARG157A, ARG157J, GLU155A, GLU155J, HIS159A, HIS159J, LEU153A, LEU153J, LEU156A, LEU156J, SER160A, SER160J, THR152A, THR152J
• B-C: ALA113C, ALA125C, ALA140C, ALA142C, ALA145C, ALA146C, ALA148C, ALA150C, ALA158C, ALA21B, ALA59B, ALA66B, ALA70B, ALA75C, ALA78C, ALA96B, ALA96C, ARG103B, ARG103C, ARG128C, ARG154C, ARG157C, ARG55B, ARG71B, ARG84C, ASN114C, ASN120C, ASN72B, ASP107B, ASP107C, ASP127C, ASP137C, ASP74C, ASP91B, ASP91C, ASP95B, ASP95C, CYS94B, CYS94C, GLN124C, GLN141C, GLN67B, GLN86B, GLN99B, GLN99C, GLU136C, GLU155C, GLU61B, GLU68B, GLY100B, GLY100C, GLY115C, GLY58B, GLY85B, HIS73B, HIS89B, ILE112C, ILE60B, ILE62B, ILE83C, LEU101B, LEU101C, LEU106C, LEU117C, LEU147C, LEU153C, LEU156C, LEU57B, LEU69B, LYS138C, PHE90B, PHE90C, PRO111C, PRO63B, PRO88B, PRO88C, SER105B, SER105C, SER108C, SER109C, THR102B, THR102C, THR110C, THR118C, THR119C, THR121C, THR143C, THR149C, THR152C, THR52B, THR87B, THR98B, THR98C, TRP27B, TYR92B, TYR92C, VAL104B, VAL104C, VAL116C, VAL144C, VAL23B, VAL53B, VAL54B, VAL56B, VAL64B, VAL65B, VAL82C, VAL93B, VAL93C, VAL97B, VAL97C
• B-D: ARG103B, GLN99B, GLN99D, LEU106D, THR102D
• B-E: ARG103E, GLN99B, GLN99E, LEU106B, THR102B
• B-G: ALA70G, ARG71B, ARG71G, ASN72B, ASN72G, GLN67B, GLN67G, GLU68B, GLU68G, LEU69B, LEU69G, VAL64B, VAL64G
• B-H: ALA150B, ALA150H, ALA158B, ALA158H, ALA21B, ALA21H, ALA70B, ALA70H, ALA75B, ARG154B, ARG154H, ARG157B, ARG157H, ARG19B, ARG19H, ARG40B, ARG40H, ARG55B, ARG55H, ARG71B, ARG71H, ASN72B, ASN72H, ASP107B, ASP107H, ASP50B, ASP50H, ASP74B, ASP74H, GLN67B, GLU155B, GLU155H, GLU68B, GLU68H, GLY17B, GLY17H, HIS159B, HIS159H, HIS73B, HIS73H, ILE22B, ILE22H, LEU106B, LEU106H, LEU151B, LEU151H, LEU153B, LEU153H, LEU156B, LEU156H, LEU20B, LEU20H, LEU48B, LEU48H, LEU69B, LEU69H, PRO51B, PRO51H, SER108B, SER108H, SER109B, SER109H, SER160B, SER160H, SER16B, SER16H, THR110B, THR110H, THR52B, THR52H, VAL18B, VAL18H, VAL53B, VAL53H, VAL54B, VAL54H, VAL65B, VAL65H
• B-I: ALA158B, ALA158I, ARG157B, ARG157I, GLU155B, GLU155I, HIS159B, HIS159I, LEU153B, LEU153I, LEU156B, LEU156I, SER160B, SER160I, THR152B, THR152I
• C-D: ALA113D, ALA125D, ALA135D, ALA140D, ALA142D, ALA145D, ALA146D, ALA148D, ALA150D, ALA158D, ALA21C, ALA66C, ALA70C, ALA96C, ALA96D, ARG103C, ARG103D, ARG128D, ARG154D, ARG157D, ARG55C, ARG71C, ARG84D, ASN114D, ASN120D, ASN72C, ASP107C, ASP107D, ASP127D, ASP137D, ASP74D, ASP91C, ASP91D, ASP95C, ASP95D, CYS94C, CYS94D, GLN124D, GLN141D, GLN67C, GLN86C, GLN99C, GLN99D, GLU136D, GLU155D, GLU61C, GLU68C, GLY100C, GLY100D, GLY115D, GLY58C, GLY85C, HIS73C, HIS89C, ILE112D, ILE60C, ILE62C, ILE83D, LEU101C, LEU101D, LEU106D, LEU117D, LEU147D, LEU153D, LEU156D, LEU57C, LEU69C, LYS138D, PHE90C, PHE90D, PRO111D, PRO63C, PRO88C, PRO88D, SER105C, SER105D, SER108D, SER109D, THR102C, THR102D, THR110D, THR118D, THR119D, THR121D, THR143D, THR149D, THR152D, THR52C, THR87C, THR98C, THR98D, TRP27C, TYR92C, TYR92D, VAL104C, VAL104D, VAL116D, VAL144D, VAL23C, VAL53C, VAL54C, VAL56C, VAL64C, VAL65C, VAL82D, VAL93C, VAL93D, VAL97C, VAL97D
• C-E: ARG103C, GLN99C, GLN99E, LEU106E, THR102E
• C-F: ARG71C, ARG71F, ASN72C, ASN72F, GLN67C, GLN67F, GLU68C, GLU68F, LEU69C, LEU69F, VAL64C, VAL64F
• C-G: ALA150C, ALA150G, ALA158C, ALA158G, ALA21C, ALA21G, ALA70C, ALA70G, ALA75G, ARG154C, ARG154G, ARG157C, ARG157G, ARG19C, ARG19G, ARG40C, ARG40G, ARG55C, ARG55G, ARG71C, ARG71G, ASN72C, ASN72G, ASP107C, ASP107G, ASP50C, ASP50G, ASP74C, ASP74G, GLU155C, GLU155G, GLU68C, GLU68G, GLY17C, GLY17G, HIS159C, HIS159G, HIS73C, HIS73G, ILE22C, ILE22G, LEU106C, LEU106G, LEU151C, LEU151G, LEU153C, LEU153G, LEU156C, LEU156G, LEU20C, LEU48C, LEU69C, LEU69G, PRO51C, PRO51G, SER108C, SER108G, SER109C, SER109G, SER160C, SER160G, SER16C, SER16G, THR110C, THR110G, THR52C, THR52G, VAL18C, VAL18G, VAL53C, VAL53G, VAL54C, VAL54G, VAL65C, VAL65G
• C-H: ALA158C, ALA158H, ARG157C, ARG157H, GLU155C, GLU155H, HIS159C, HIS159H, LEU153C, LEU153H, LEU156C, LEU156H, SER160C, SER160H, THR152C, THR152H
• D-E: ALA113E, ALA125E, ALA135E, ALA140E, ALA142E, ALA145E, ALA146E, ALA148E, ALA150E, ALA158E, ALA21D, ALA66D, ALA70D, ALA75E, ALA78E, ALA96D, ALA96E, ARG103D, ARG103E, ARG128E, ARG154E, ARG157E, ARG55D, ARG71D, ARG84D, ARG84E, ASN114E, ASN120E, ASN72D, ASP107D, ASP107E, ASP127E, ASP137E, ASP74E, ASP91D, ASP91E, ASP95D, ASP95E, CYS94D, CYS94E, GLN124E, GLN141E, GLN67D, GLN86D, GLN99D, GLN99E, GLU136E, GLU155E, GLU61D, GLU68D, GLY100D, GLY100E, GLY115E, GLY58D, GLY85D, HIS73D, HIS89D, ILE112E, ILE60D, ILE62D, ILE83E, LEU101D, LEU101E, LEU106E, LEU10E, LEU117E, LEU147E, LEU153E, LEU156E, LEU57D, LEU69D, LYS138E, PHE90D, PHE90E, PRO111E, PRO63D, PRO88D, PRO88E, SER105D, SER105E, SER108E, SER109E, THR102D, THR102E, THR110E, THR118E, THR119E, THR121E, THR143E, THR149E, THR152E, THR52D, THR87D, THR98D, THR98E, TRP27D, TYR92D, TYR92E, VAL104D, VAL104E, VAL116E, VAL144E, VAL23D, VAL53D, VAL54D, VAL56D, VAL64D, VAL65D, VAL82E, VAL93D, VAL93E, VAL97D, VAL97E
• D-F: ALA150D, ALA150F, ALA158D, ALA158F, ALA21D, ALA21F, ALA70D, ALA70F, ALA75D, ALA75F, ARG154D, ARG154F, ARG157D, ARG157F, ARG19D, ARG19F, ARG40D, ARG40F, ARG55D, ARG55F, ARG71D, ARG71F, ASN72D, ASN72F, ASP107D, ASP107F, ASP50D, ASP50F, ASP74D, ASP74F, GLN67D, GLU155D, GLU155F, GLU68D, GLU68F, GLY17D, GLY17F, HIS159D, HIS159F, HIS73D, HIS73F, ILE22D, ILE22F, LEU106D, LEU106F, LEU151D, LEU151F, LEU153D, LEU153F, LEU156D, LEU156F, LEU69D, LEU69F, PRO51D, PRO51F, SER108D, SER108F, SER109D, SER109F, SER160D, SER160F, SER16D, SER16F, THR110D, THR110F, THR52D, THR52F, VAL18D, VAL18F, VAL53D, VAL53F, VAL54D, VAL54F, VAL65D, VAL65F
• D-G: ALA158D, ALA158G, ARG157D, ARG157G, GLU155D, GLU155G, HIS159D, HIS159G, LEU153D, LEU153G, LEU156D, LEU156G, SER160D, SER160G, THR152D, THR152G
• D-J: ARG71D, ARG71J, ASN72D, ASN72J, GLN67D, GLN67J, GLU68D, GLU68J, LEU69D, LEU69J, VAL64D, VAL64J
• E-F: ALA158E, ALA158F, ARG157E, ARG157F, GLU155E, GLU155F, HIS159E, HIS159F, LEU153E, LEU153F, LEU156E, LEU156F, SER160E, SER160F, THR152E, THR152F
• E-I: ARG71E, ARG71I, ASN72E, ASN72I, GLN67E, GLN67I, GLU68E, GLU68I, LEU69E, LEU69I, VAL64E, VAL64I
• E-J: ALA150E, ALA150J, ALA158E, ALA158J, ALA21E, ALA21J, ALA70E, ALA70J, ALA75E, ALA75J, ARG154E, ARG154J, ARG157E, ARG157J, ARG19E, ARG19J, ARG40E, ARG40J, ARG55J, ARG71E, ARG71J, ASN72E, ASN72J, ASP107E, ASP107J, ASP50E, ASP50J, ASP74E, ASP74J, GLU155E, GLU155J, GLU68E, GLU68J, GLY17E, GLY17J, HIS159E, HIS159J, HIS73E, HIS73J, ILE22E, ILE22J, LEU106E, LEU106J, LEU151E, LEU153E, LEU153J, LEU156E, LEU156J, LEU20E, LEU69E, LEU69J, PRO51E, PRO51J, SER108E, SER108J, SER109E, SER109J, SER160E, SER160J, SER16E, SER16J, THR110E, THR110J, THR52E, THR52J, VAL18E, VAL18J, VAL53E, VAL53J, VAL54E, VAL54J, VAL65E, VAL65J
• F-G: ALA113G, ALA125G, ALA135G, ALA140G, ALA142G, ALA145G, ALA146G, ALA148G, ALA150G, ALA158G, ALA21F, ALA66F, ALA70F, ALA78G, ALA96F, ALA96G, ARG103F, ARG103G, ARG128G, ARG154G, ARG157G, ARG55F, ARG71F, ARG84F, ARG84G, ASN114G, ASN120G, ASN72F, ASP107F, ASP107G, ASP127G, ASP137G, ASP74G, ASP91F, ASP91G, ASP95F, ASP95G, CYS94F, CYS94G, GLN124G, GLN141G, GLN67F, GLN86F, GLN99F, GLN99G, GLU136G, GLU155G, GLU61F, GLU68F, GLY100F, GLY100G, GLY115G, GLY58F, GLY85F, HIS73F, HIS89F, ILE112G, ILE60F, ILE62F, ILE83G, LEU101F, LEU101G, LEU106G, LEU117G, LEU147G, LEU153G, LEU156G, LEU57F, LEU69F, LYS138G, PHE90F, PHE90G, PRO111G, PRO63F, PRO88F, SER105F, SER105G, SER108G, SER109G, THR102F, THR102G, THR110G, THR118G, THR119G, THR121G, THR143G, THR149G, THR152G, THR52F, THR87F, THR98F, THR98G, TRP27F, TYR92F, TYR92G, VAL104F, VAL104G, VAL116G, VAL144G, VAL23F, VAL53F, VAL54F, VAL56F, VAL64F, VAL65F, VAL82G, VAL93F, VAL93G, VAL97F, VAL97G
• F-H: ARG103F, GLN99F, GLN99H, LEU106H
• F-I: ARG103I, GLN99F, GLN99I, LEU106F, THR102F
• F-J: ALA113F, ALA125F, ALA140F, ALA142F, ALA145F, ALA146F, ALA148F, ALA150F, ALA158F, ALA21J, ALA59J, ALA66J, ALA70J, ALA75F, ALA78F, ALA96F, ALA96J, ARG103F, ARG103J, ARG128F, ARG154F, ARG157F, ARG55J, ARG71J, ARG84F, ASN114F, ASN120F, ASN72J, ASP107F, ASP107J, ASP127F, ASP137F, ASP74F, ASP91F, ASP91J, ASP95F, ASP95J, CYS94F, CYS94J, GLN124F, GLN141F, GLN67J, GLN86J, GLN99F, GLN99J, GLU123F, GLU136F, GLU155F, GLU61J, GLU68J, GLY100F, GLY100J, GLY115F, GLY58J, GLY85J, HIS73J, HIS89F, HIS89J, ILE112F, ILE60J, ILE62J, ILE83F, LEU101F, LEU101J, LEU106F, LEU117F, LEU147F, LEU153F, LEU156F, LEU57J, LEU69J, LYS138F, PHE90F, PHE90J, PRO111F, PRO63J, PRO88F, PRO88J, SER105F, SER105J, SER108F, SER109F, THR102F, THR102J, THR110F, THR118F, THR119F, THR121F, THR143F, THR149F, THR152F, THR52J, THR87J, THR98F, THR98J, TRP27J, TYR92F, TYR92J, VAL104F, VAL104J, VAL116F, VAL144F, VAL23J, VAL42F, VAL53J, VAL54J, VAL56J, VAL64J, VAL65J, VAL82F, VAL93F, VAL93J, VAL97F, VAL97J
• G-H: ALA113H, ALA125H, ALA135H, ALA140H, ALA142H, ALA145H, ALA146H, ALA148H, ALA150H, ALA158H, ALA21G, ALA66G, ALA70G, ALA75H, ALA78H, ALA96G, ALA96H, ARG103G, ARG103H, ARG128H, ARG154H, ARG157H, ARG55G, ARG71G, ARG84H, ASN114H, ASN120H, ASN72G, ASP107G, ASP107H, ASP127H, ASP137H, ASP74H, ASP91G, ASP91H, ASP95G, ASP95H, CYS94G, CYS94H, GLN124H, GLN141H, GLN67G, GLN86G, GLN99G, GLN99H, GLU136H, GLU155H, GLU61G, GLU68G, GLY100G, GLY100H, GLY115H, GLY58G, GLY85G, HIS73G, HIS89G, ILE112H, ILE60G, ILE62G, ILE83H, LEU101G, LEU101H, LEU106H, LEU117H, LEU147H, LEU153H, LEU156H, LEU57G, LEU69G, LYS138H, PHE90G, PHE90H, PRO111H, PRO63G, PRO88G, PRO88H, SER105G, SER105H, SER108H, SER109H, THR102G, THR102H, THR110H, THR118H, THR119H, THR121H, THR143H, THR149H, THR152H, THR52G, THR87G, THR98G, THR98H, TRP27G, TYR92G, TYR92H, VAL104G, VAL104H, VAL116H, VAL144H, VAL23G, VAL53G, VAL54G, VAL56G, VAL64G, VAL65G, VAL82H, VAL93G, VAL93H, VAL97G, VAL97H
• G-I: ARG103G, GLN99G, GLN99I, LEU106I, THR102I
• G-J: ARG103J, GLN99G, GLN99J, LEU106G, THR102G
• H-I: ALA113I, ALA125I, ALA135I, ALA140I, ALA142I, ALA145I, ALA146I, ALA148I, ALA150I, ALA158I, ALA21H, ALA66H, ALA70H, ALA75I, ALA78I, ALA96H, ALA96I, ARG103H, ARG103I, ARG128I, ARG154I, ARG157I, ARG55H, ARG71H, ARG84I, ASN114I, ASN120I, ASN72H, ASP107H, ASP107I, ASP127I, ASP74I, ASP91H, ASP91I, ASP95H, ASP95I, CYS94H, CYS94I, GLN124I, GLN141I, GLN67H, GLN86H, GLN99H, GLN99I, GLU136I, GLU155I, GLU61H, GLU68H, GLY100H, GLY100I, GLY115I, GLY58H, GLY85H, HIS73H, HIS89H, HIS89I, ILE112I, ILE60H, ILE62H, ILE83I, LEU101H, LEU101I, LEU106I, LEU117I, LEU147I, LEU153I, LEU156I, LEU57H, LEU69H, LYS138I, PHE90H, PHE90I, PRO111I, PRO63H, PRO88H, PRO88I, SER105H, SER105I, SER108I, SER109I, SER26H, THR102H, THR102I, THR110I, THR118I, THR119I, THR121I, THR143I, THR149I, THR152I, THR52H, THR87H, THR98H, THR98I, TRP27H, TYR92H, TYR92I, VAL104H, VAL104I, VAL116I, VAL144I, VAL23H, VAL53H, VAL54H, VAL56H, VAL64H, VAL65H, VAL82I, VAL93H, VAL93I, VAL97H, VAL97I
• H-J: ARG103H, GLN99H, GLN99J, LEU106J, THR102J
• I-J: ALA113J, ALA125J, ALA135J, ALA140J, ALA142J, ALA145J, ALA146J, ALA148J, ALA150J, ALA158J, ALA21I, ALA66I, ALA70I, ALA75J, ALA78J, ALA96I, ALA96J, ARG103I, ARG103J, ARG128J, ARG154J, ARG157J, ARG55I, ARG71I, ARG84J, ASN114J, ASN120J, ASN72I, ASP107I, ASP107J, ASP127J, ASP137J, ASP74J, ASP91I, ASP91J, ASP95I, ASP95J, CYS94I, CYS94J, GLN124J, GLN141J, GLN67I, GLN86I, GLN99I, GLN99J, GLU123J, GLU136J, GLU155J, GLU61I, GLU68I, GLY100I, GLY100J, GLY115J, GLY58I, GLY85I, HIS73I, HIS89I, HIS89J, ILE112J, ILE60I, ILE62I, ILE83J, LEU101I, LEU101J, LEU106J, LEU117J, LEU147J, LEU153J, LEU156J, LEU57I, LEU69I, LYS138J, PHE90I, PHE90J, PRO111J, PRO63I, PRO88I, PRO88J, SER105I, SER105J, SER108J, SER109J, THR102I, THR102J, THR110J, THR118J, THR119J, THR121J, THR143J, THR149J, THR152J, THR52I, THR87I, THR98I, THR98J, TRP27I, TYR92I, TYR92J, VAL104I, VAL104J, VAL116J, VAL144J, VAL23I, VAL53I, VAL54I, VAL56I, VAL64I, VAL65I, VAL82J, VAL93I, VAL93J, VAL97I, VAL97J