2VBI

holostructure of pyruvate decarboxylase from acetobacter pasteurianus

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 143
  • Norm. En. per Res.: -4.6899
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-201.7089	-145.9621	-1149.3	-1496.971	360	38	28	44018	16	77	57
A-C	-3.3447	8.375	-77.6778	-72.6475	72	7	0	3609	0	22	28
A-D	-165.9913	-115.0973	-389.572	-670.6606	143	29	2	14601	10	79	61
A-F	-2.5316	-14.6192	-33.5775	-50.7282	71	3	0	2339	2	24	23
A-G	0.0	-7.577	-4.3114	-11.8884	13	0	0	279	0	7	7
B-C	-144.6564	-114.0942	-362.05	-620.8006	144	24	2	14125	10	76	58
B-D	-4.2517	7.8242	-90.1895	-86.6171	74	7	0	4038	0	22	28
C-D	-209.9688	-142.1127	-1156.82	-1508.9015	355	37	28	44328	16	76	57
D-F	-2.6932	13.6851	-33.8561	-22.8642	24	4	0	1461	0	17	16
D-G	-2.2915	-10.8007	-45.2274	-58.3196	84	3	0	2983	0	32	30
E-F	-215.8398	-150.8749	-1171.34	-1538.0547	357	37	27	44394	16	78	58
E-G	-4.6156	6.0989	-90.2898	-88.8065	74	8	0	3978	0	22	28
E-H	-144.711	-111.2574	-351.938	-607.9065	145	23	2	14081	10	75	61
F-G	-147.3111	-109.4077	-369.518	-626.2368	144	24	2	14359	10	76	61
F-H	-4.8147	8.0477	-96.4235	-93.1905	75	7	0	4257	0	22	28
G-H	-205.0038	-147.7339	-1159.57	-1512.3077	356	36	28	44234	16	77	57

Interface residues

• A-B: ALA100A, ALA100B, ALA128A, ALA128B, ALA141A, ALA141B, ALA167B, ALA171A, ALA171B, ALA23A, ALA23B, ALA25A, ALA25B, ALA443A, ALA443B, ALA447A, ALA447B, ALA486A, ALA486B, ALA494A, ALA494B, ALA548A, ALA548B, ALA552A, ALA552B, ALA77A, ALA77B, ALA80A, ALA80B, ALA83A, ALA83B, ALA87A, ALA87B, ALA89A, ALA89B, ARG129A, ARG129B, ARG451A, ARG451B, ARG464A, ARG464B, ARG553A, ARG553B, ASN102A, ASN102B, ASN104A, ASN104B, ASN169A, ASN169B, ASN288A, ASN288B, ASN29A, ASN29B, ASN462A, ASN462B, ASN478A, ASN478B, ASN482A, ASN482B, ASN493A, ASN493B, ASN49A, ASN49B, ASN52A, ASN52B, ASN551A, ASN551B, ASN82A, ASN82B, ASN91A, ASN91B, ASP105A, ASP105B, ASP27A, ASP27B, ASP289A, ASP289B, ASP34A, ASP34B, ASP474A, ASP474B, ASP484A, ASP484B, CYS133A, CYS133B, CYS168A, CYS168B, CYS47A, CYS47B, CYS48A, CYS48B, GLN106A, GLN106B, GLN124A, GLN124B, GLN130A, GLN130B, GLN35A, GLN35B, GLN407A, GLN407B, GLN440A, GLN440B, GLN444A, GLN444B, GLN448A, GLN448B, GLN44A, GLN44B, GLN530A, GLN530B, GLU126A, GLU126B, GLU158A, GLU158B, GLU173A, GLU173B, GLU308A, GLU308B, GLU405A, GLU405B, GLU445A, GLU445B, GLU453A, GLU453B, GLU469A, GLU469B, GLU490A, GLU490B, GLU496A, GLU496B, GLU50A, GLU50B, GLU528A, GLU528B, GLU90A, GLU90B, GLY109A, GLY109B, GLY117A, GLY117B, GLY26A, GLY26B, GLY294A, GLY294B, GLY409A, GLY409B, GLY412A, GLY412B, GLY437A, GLY437B, GLY475A, GLY475B, GLY487A, GLY487B, GLY495A, GLY495B, GLY497A, GLY497B, GLY499A, GLY499B, GLY76A, GLY76B, GLY85A, GLY85B, GLY86A, GLY86B, HIS110A, HIS110B, HIS113A, HIS113B, HIS114A, HIS114B, HIS21A, HIS21B, HIS410A, HIS410B, HIS473A, HIS473B, HIS498A, HIS498B, ILE111A, ILE111B, ILE116A, ILE116B, ILE170A, ILE170B, ILE411A, ILE411B, ILE45A, ILE45B, ILE468A, ILE468B, ILE470A, ILE470B, ILE472A, ILE472B, ILE480A, ILE480B, ILE78A, ILE78B, LEU112A, LEU112B, LEU125A, LEU125B, LEU30A, LEU30B, LEU32A, LEU32B, LEU33A, LEU33B, LEU36A, LEU36B, LEU37A, LEU37B, LEU441A, LEU441B, LEU488A, LEU488B, LEU51A, LEU51B, LEU84A, LEU84B, LYS118A, LYS118B, LYS160A, LYS160B, LYS219A, LYS219B, LYS300A, LYS300B, LYS40A, LYS40B, LYS481A, LYS481B, LYS503A, LYS503B, LYS554A, LYS554B, MET127A, MET127B, MET406A, MET406B, MET449A, MET449B, MET489A, MET489B, MET81A, MET81B, PHE287A, PHE287B, PHE439A, PHE439B, PHE492A, PHE492B, PHE55A, PHE55B, PHE73A, PHE73B, PRO101A, PRO101B, PRO161A, PRO161B, PRO174A, PRO174B, PRO285A, PRO285B, PRO476A, PRO476B, SER103A, SER103B, SER122A, SER122B, SER172A, SER172B, SER291A, SER291B, SER438A, SER438B, SER549A, SER549B, SER74A, SER74B, SER79A, SER79B, THR108A, THR108B, THR115A, THR115B, THR132A, THR132B, THR292A, THR292B, THR384A, THR384B, THR442A, THR442B, THR4A, THR4B, THR550A, THR550B, THR555A, THR555B, THR72A, THR72B, TRP295A, TRP295B, TRP298A, TRP298B, TRP388A, TRP388B, TRP408A, TRP408B, TRP413A, TRP413B, TRP483A, TRP483B, TRP543A, TRP543B, TYR121A, TYR121B, TYR123A, TYR123B, TYR28A, TYR28B, TYR290A, TYR290B, TYR452A, TYR452B, TYR466A, TYR466B, TYR46A, TYR46B, TYR477A, TYR477B, TYR479A, TYR479B, TYR485A, TYR485B, TYR88A, TYR88B, VAL131A, VAL131B, VAL24A, VAL24B, VAL286A, VAL286B, VAL31A, VAL31B, VAL446A, VAL446B, VAL450A, VAL450B, VAL491A, VAL491B, VAL547A, VAL547B, VAL5B, VAL75A, VAL75B
• A-C: ALA135A, ALA135C, ALA141A, ALA141C, ALA144A, ALA144C, ALA146A, ALA146C, ALA167A, ALA167C, ARG129A, ARG129C, ASN102A, ASN102C, ASN104A, ASN104C, ASP105A, ASP105C, ASP120A, ASP120C, ASP140A, ASP140C, GLN106A, GLN106C, GLN130A, GLN130C, GLU126A, GLU126C, GLU136A, GLU136C, GLY107A, GLY107C, GLY109A, GLY109C, HIS110A, HIS110C, HIS142A, HIS142C, HIS150A, HIS150C, ILE111A, ILE111C, ILE116A, ILE116C, ILE138A, ILE138C, ILE170A, ILE170C, LEU125A, LEU125C, LYS118A, LYS118C, LYS147A, LYS147C, SER103A, SER103C, SER122A, SER122C, SER137A, SER137C, SER143A, SER143C, THR108A, THR108C, THR119A, THR119C, THR139A, THR139C, TYR121A, TYR121C, TYR123A, TYR123C
• A-D: ALA144A, ALA144D, ALA146A, ALA146D, ALA197A, ALA197D, ALA198A, ALA198D, ALA201A, ALA201D, ALA318A, ALA318D, ARG129A, ARG129D, ARG12A, ARG12D, ARG153A, ARG153D, ARG157A, ARG157D, ARG177A, ARG177D, ARG311A, ARG311D, ARG317A, ARG317D, ASP140A, ASP140D, ASP149A, ASP149D, ASP191A, ASP191D, ASP310A, ASP310D, ASP315A, ASP315D, ASP320A, ASP320D, CYS133A, CYS133D, CYS175A, CYS175D, GLN130A, GLN130D, GLN15A, GLN15D, GLU11A, GLU11D, GLU126A, GLU126D, GLU136D, GLU158A, GLU158D, GLU187A, GLU187D, GLU189A, GLU189D, GLU308A, GLU308D, GLY179A, GLY179D, GLY301A, GLY316A, GLY316D, GLY321A, GLY321D, HIS142A, HIS142D, HIS150A, HIS150D, HIS192A, HIS192D, ILE148A, ILE148D, ILE152A, ILE152D, ILE190A, ILE190D, LEU184A, LEU184D, LEU185A, LEU185D, LEU195A, LEU195D, LEU306A, LEU306D, LYS147A, LYS147D, LYS196A, LYS196D, LYS300A, LYS300D, PHE322A, PHE322D, PRO145A, PRO145D, PRO178A, PRO178D, PRO180A, PRO180D, PRO188A, PRO188D, PRO302A, PRO302D, SER143A, SER143D, SER182A, SER182D, SER183A, SER183D, SER186A, SER186D, SER194A, SER194D, THR132A, THR132D, THR154A, THR154D, THR193A, THR193D, THR313A, THR313D, THR323A, THR323D, TRP298A, TRP298D, TYR319A, TYR319D, TYR3A, TYR3D, TYR88A, TYR8A, TYR8D, VAL131A, VAL131D, VAL176A, VAL176D, VAL181A, VAL181D, VAL312A, VAL312D, VAL314A, VAL314D
• A-F: ALA204A, ALA227F, ALA255A, ALA330F, ALA332A, ALA335A, ALA337A, ARG325A, ARG325F, ARG338A, ARG398A, ARG398F, ARG401F, ARG428F, ASN224F, ASN377F, ASN64F, ASP191A, ASP200A, ASP234A, ASP253F, ASP427F, GLN15F, GLN237A, GLN329A, GLN329F, GLN426F, GLN429F, GLU207A, GLU230A, GLU333A, GLU333F, GLY17F, GLY399F, GLY424F, HIS192A, HIS192F, HIS254A, ILE16F, ILE190A, LEU18F, LEU195A, LEU195F, LEU236A, LYS196A, LYS196F, LYS19A, LYS19F, LYS235A, LYS235F, LYS334A, LYS334F, PRO180A, PRO180F, PRO336A, PRO339A, SER182A, SER182F, SER183A, SER183F, SER376F, SER425F, SER63F, THR193A, THR231A, THR375F, VAL14F, VAL181A, VAL181F, VAL199A, VAL203A
• A-G: ALA197G, ASP191A, ASP191G, GLU189A, HIS192A, HIS192G, ILE190A, LYS196A, LYS196G, SER194A, SER194G, THR193A, THR193G
• B-C: ALA144B, ALA144C, ALA146B, ALA146C, ALA197B, ALA197C, ALA198B, ALA198C, ALA201B, ALA201C, ALA318B, ALA318C, ARG129B, ARG129C, ARG12B, ARG12C, ARG153B, ARG153C, ARG157B, ARG157C, ARG177B, ARG177C, ARG311B, ARG311C, ARG317B, ARG317C, ASP140B, ASP140C, ASP149B, ASP149C, ASP191B, ASP191C, ASP310B, ASP310C, ASP315B, ASP315C, ASP320B, ASP320C, CYS133B, CYS133C, CYS175B, CYS175C, GLN130B, GLN130C, GLN15B, GLN15C, GLU11B, GLU11C, GLU126B, GLU126C, GLU158B, GLU158C, GLU187B, GLU187C, GLU189B, GLU189C, GLU308B, GLU308C, GLY179B, GLY179C, GLY301B, GLY301C, GLY316B, GLY316C, GLY321B, GLY321C, HIS142B, HIS142C, HIS150B, HIS150C, HIS192B, HIS192C, ILE148B, ILE148C, ILE152B, ILE152C, ILE190B, ILE190C, LEU184B, LEU184C, LEU185B, LEU185C, LEU195B, LEU195C, LEU306B, LEU306C, LYS147B, LYS147C, LYS196B, LYS196C, LYS300B, LYS300C, PHE322B, PHE322C, PRO145B, PRO145C, PRO178B, PRO178C, PRO180B, PRO180C, PRO188B, PRO188C, PRO302B, PRO302C, SER143B, SER143C, SER182B, SER182C, SER183B, SER183C, SER186B, SER186C, SER194B, SER194C, THR132B, THR132C, THR154B, THR154C, THR193B, THR193C, THR313B, THR313C, THR323B, THR323C, TRP298B, TRP298C, TYR319B, TYR319C, TYR3B, TYR3C, TYR88B, TYR88C, TYR8B, TYR8C, VAL131B, VAL131C, VAL176B, VAL176C, VAL181B, VAL181C, VAL312B, VAL312C, VAL314B, VAL314C
• B-D: ALA135B, ALA135D, ALA141B, ALA141D, ALA144B, ALA144D, ALA146B, ALA146D, ALA167B, ALA167D, ARG129B, ARG129D, ASN102B, ASN102D, ASN104B, ASN104D, ASN169B, ASN169D, ASP105B, ASP105D, ASP120B, ASP120D, ASP140B, ASP140D, GLN106B, GLN106D, GLN130B, GLN130D, GLU126B, GLU126D, GLU136B, GLU136D, GLY107B, GLY107D, GLY109B, GLY109D, HIS110B, HIS110D, HIS142B, HIS142D, HIS150B, HIS150D, ILE111B, ILE111D, ILE116B, ILE116D, ILE138B, ILE138D, ILE170B, ILE170D, LEU125B, LEU125D, LYS118B, LYS118D, LYS147B, LYS147D, SER103B, SER103D, SER122B, SER122D, SER137B, SER137D, SER143B, SER143D, THR108B, THR108D, THR119B, THR119D, THR139B, THR139D, TYR121B, TYR121D, TYR123B, TYR123D
• C-D: ALA100C, ALA100D, ALA128C, ALA128D, ALA171C, ALA171D, ALA23C, ALA23D, ALA25C, ALA25D, ALA443C, ALA443D, ALA447C, ALA447D, ALA486C, ALA486D, ALA494C, ALA494D, ALA548C, ALA548D, ALA552C, ALA552D, ALA77C, ALA77D, ALA80C, ALA80D, ALA83C, ALA83D, ALA87C, ALA87D, ALA89C, ALA89D, ARG129C, ARG129D, ARG451C, ARG451D, ARG464C, ARG464D, ARG553C, ARG553D, ASN102C, ASN102D, ASN104C, ASN104D, ASN169C, ASN169D, ASN288C, ASN288D, ASN29C, ASN29D, ASN462C, ASN462D, ASN478C, ASN478D, ASN482C, ASN482D, ASN493C, ASN493D, ASN49C, ASN49D, ASN52C, ASN52D, ASN551C, ASN551D, ASN82C, ASN82D, ASN91C, ASN91D, ASP105C, ASP105D, ASP27C, ASP27D, ASP289C, ASP289D, ASP34C, ASP34D, ASP474C, ASP474D, ASP484C, ASP484D, CYS133C, CYS133D, CYS168C, CYS168D, CYS47C, CYS47D, CYS48C, CYS48D, GLN106C, GLN106D, GLN124C, GLN124D, GLN130C, GLN130D, GLN35C, GLN35D, GLN407C, GLN407D, GLN440C, GLN440D, GLN444C, GLN444D, GLN448C, GLN448D, GLN44C, GLN44D, GLN530C, GLN530D, GLU126C, GLU126D, GLU158C, GLU158D, GLU173C, GLU173D, GLU308C, GLU308D, GLU405C, GLU405D, GLU445C, GLU445D, GLU453C, GLU453D, GLU469C, GLU469D, GLU490C, GLU490D, GLU496C, GLU496D, GLU50C, GLU50D, GLU528C, GLU528D, GLU90C, GLU90D, GLY109C, GLY109D, GLY117C, GLY117D, GLY26C, GLY26D, GLY409C, GLY409D, GLY412C, GLY412D, GLY437C, GLY437D, GLY475C, GLY475D, GLY487C, GLY487D, GLY495C, GLY495D, GLY497C, GLY497D, GLY499C, GLY499D, GLY76C, GLY76D, GLY85C, GLY85D, GLY86C, GLY86D, HIS110C, HIS110D, HIS113C, HIS113D, HIS114C, HIS114D, HIS21C, HIS21D, HIS410C, HIS410D, HIS473C, HIS473D, HIS498C, HIS498D, ILE111C, ILE111D, ILE116C, ILE116D, ILE170C, ILE170D, ILE411C, ILE411D, ILE45C, ILE45D, ILE468C, ILE468D, ILE470C, ILE470D, ILE472C, ILE472D, ILE480C, ILE480D, ILE78C, ILE78D, LEU112C, LEU112D, LEU125C, LEU125D, LEU30C, LEU30D, LEU32C, LEU32D, LEU33C, LEU33D, LEU36C, LEU36D, LEU37C, LEU37D, LEU441C, LEU441D, LEU488C, LEU488D, LEU51C, LEU51D, LEU84C, LEU84D, LYS118C, LYS118D, LYS160C, LYS160D, LYS219C, LYS219D, LYS300C, LYS300D, LYS40C, LYS40D, LYS481C, LYS481D, LYS503C, LYS503D, LYS554C, LYS554D, MET127C, MET127D, MET406C, MET406D, MET449C, MET449D, MET489C, MET489D, MET81C, MET81D, PHE287C, PHE287D, PHE439C, PHE439D, PHE492C, PHE492D, PHE55C, PHE55D, PHE73C, PHE73D, PRO101C, PRO101D, PRO161C, PRO161D, PRO174C, PRO174D, PRO285C, PRO285D, PRO476C, PRO476D, SER103C, SER103D, SER122C, SER122D, SER172C, SER172D, SER291C, SER291D, SER438C, SER438D, SER549C, SER549D, SER74C, SER74D, SER79C, SER79D, THR108C, THR108D, THR115C, THR115D, THR132C, THR132D, THR292C, THR292D, THR384C, THR384D, THR442C, THR442D, THR4C, THR4D, THR550C, THR550D, THR555C, THR555D, THR72C, THR72D, TRP295C, TRP295D, TRP298C, TRP298D, TRP388C, TRP388D, TRP408C, TRP408D, TRP413C, TRP413D, TRP483C, TRP483D, TRP543C, TRP543D, TYR121C, TYR121D, TYR123C, TYR123D, TYR28C, TYR28D, TYR290C, TYR290D, TYR452C, TYR452D, TYR466C, TYR466D, TYR46C, TYR46D, TYR477C, TYR477D, TYR479C, TYR479D, TYR485C, TYR485D, TYR88C, TYR88D, VAL131C, VAL131D, VAL24C, VAL24D, VAL286C, VAL286D, VAL31C, VAL31D, VAL446C, VAL446D, VAL450C, VAL450D, VAL491C, VAL491D, VAL547C, VAL547D, VAL5C, VAL75C, VAL75D
• D-F: ALA197D, ALA197F, ALA330F, ASP191D, ASP191F, ASP200D, ASP200F, GLU189F, GLU333D, HIS192D, HIS192F, ILE190D, ILE190F, LEU195D, LEU195F, LYS196D, LYS196F, LYS334D, LYS334F, SER182D, SER182F, SER194F, THR193D, THR193F
• D-G: ALA197G, ALA204G, ALA225D, ALA227D, ALA227G, ALA228D, ALA228G, ALA233G, ALA255D, ALA326G, ALA330D, ALA330G, ALA332D, ALA332G, ALA335G, ALA337G, ARG325D, ARG325G, ARG338G, ARG398D, ARG398G, ARG401D, ARG428D, ASN224D, ASN224G, ASN377D, ASN64D, ASP191G, ASP200G, ASP234D, ASP234G, ASP253D, ASP427D, GLN15D, GLN237G, GLN329D, GLN329G, GLN426D, GLN429D, GLU207G, GLU230D, GLU230G, GLU333D, GLU333G, GLY17D, GLY399D, GLY65D, HIS192G, HIS254G, ILE16D, LEU184D, LEU185D, LEU185G, LEU195G, LEU226D, LEU236G, LYS196D, LYS196G, LYS19D, LYS235G, LYS334D, LYS334G, PRO180G, PRO251D, PRO336G, PRO339G, PRO397D, SER182D, SER182G, SER183D, SER183G, SER194G, SER376D, SER425D, SER63D, THR193G, THR231D, THR231G, THR375D, THR378D, VAL14D, VAL181D, VAL181G, VAL203G
• E-F: ALA100E, ALA100F, ALA128E, ALA128F, ALA141E, ALA141F, ALA171E, ALA171F, ALA23E, ALA23F, ALA25E, ALA25F, ALA443E, ALA443F, ALA447E, ALA447F, ALA486E, ALA486F, ALA494E, ALA494F, ALA548E, ALA548F, ALA552E, ALA552F, ALA77E, ALA77F, ALA80E, ALA80F, ALA83E, ALA83F, ALA87E, ALA87F, ALA89E, ALA89F, ARG129E, ARG129F, ARG451E, ARG451F, ARG464E, ARG464F, ARG553E, ARG553F, ASN102E, ASN102F, ASN104E, ASN104F, ASN169E, ASN169F, ASN288E, ASN288F, ASN29E, ASN29F, ASN462E, ASN462F, ASN478E, ASN478F, ASN482E, ASN482F, ASN493E, ASN493F, ASN49E, ASN49F, ASN52E, ASN52F, ASN551E, ASN551F, ASN82E, ASN82F, ASN91E, ASN91F, ASP105E, ASP105F, ASP27E, ASP27F, ASP289E, ASP289F, ASP34E, ASP34F, ASP474E, ASP474F, ASP484E, ASP484F, CYS133E, CYS133F, CYS168E, CYS168F, CYS47E, CYS47F, CYS48E, CYS48F, GLN106E, GLN106F, GLN124E, GLN124F, GLN130E, GLN130F, GLN35E, GLN35F, GLN407E, GLN407F, GLN440E, GLN440F, GLN444E, GLN444F, GLN448E, GLN448F, GLN44E, GLN44F, GLN530E, GLN530F, GLU126E, GLU126F, GLU158F, GLU173E, GLU173F, GLU308E, GLU308F, GLU405E, GLU405F, GLU445E, GLU445F, GLU453E, GLU453F, GLU469E, GLU469F, GLU490E, GLU490F, GLU496E, GLU496F, GLU50E, GLU50F, GLU528E, GLU528F, GLU90E, GLU90F, GLY109E, GLY109F, GLY117E, GLY117F, GLY26E, GLY26F, GLY294E, GLY409E, GLY409F, GLY412E, GLY412F, GLY437E, GLY437F, GLY465F, GLY475E, GLY475F, GLY487E, GLY487F, GLY495E, GLY495F, GLY497E, GLY497F, GLY499E, GLY499F, GLY76E, GLY76F, GLY85E, GLY85F, GLY86E, GLY86F, HIS110E, HIS110F, HIS113E, HIS113F, HIS114E, HIS114F, HIS21E, HIS21F, HIS410E, HIS410F, HIS473E, HIS473F, HIS498E, HIS498F, ILE111E, ILE111F, ILE116E, ILE116F, ILE170E, ILE170F, ILE411E, ILE411F, ILE45E, ILE45F, ILE468E, ILE468F, ILE470E, ILE470F, ILE472E, ILE472F, ILE480E, ILE480F, ILE78E, ILE78F, LEU112E, LEU112F, LEU125E, LEU125F, LEU30E, LEU30F, LEU32E, LEU32F, LEU33E, LEU33F, LEU36E, LEU36F, LEU37E, LEU37F, LEU441E, LEU441F, LEU488E, LEU488F, LEU51E, LEU51F, LEU84E, LEU84F, LYS118E, LYS118F, LYS160E, LYS160F, LYS219E, LYS219F, LYS300E, LYS300F, LYS40E, LYS40F, LYS481E, LYS481F, LYS503E, LYS503F, LYS554E, LYS554F, MET127E, MET127F, MET406E, MET406F, MET449E, MET449F, MET489E, MET489F, MET81E, MET81F, PHE287E, PHE287F, PHE439E, PHE439F, PHE492E, PHE492F, PHE55E, PHE55F, PHE73E, PHE73F, PRO101E, PRO101F, PRO161E, PRO161F, PRO174E, PRO174F, PRO285E, PRO285F, PRO476E, PRO476F, SER103E, SER103F, SER122E, SER122F, SER172E, SER172F, SER291E, SER291F, SER438E, SER438F, SER549E, SER549F, SER74E, SER74F, SER79E, SER79F, THR108E, THR108F, THR115E, THR115F, THR132E, THR132F, THR292E, THR292F, THR384E, THR384F, THR442E, THR442F, THR4E, THR4F, THR550E, THR550F, THR555E, THR555F, THR72E, THR72F, TRP295E, TRP295F, TRP298E, TRP298F, TRP388E, TRP388F, TRP408E, TRP408F, TRP413E, TRP413F, TRP483E, TRP483F, TRP543E, TRP543F, TYR121E, TYR121F, TYR123E, TYR123F, TYR28E, TYR28F, TYR290E, TYR290F, TYR452E, TYR452F, TYR466E, TYR466F, TYR46E, TYR46F, TYR477E, TYR477F, TYR479E, TYR479F, TYR485E, TYR485F, TYR88E, TYR88F, VAL131E, VAL131F, VAL24E, VAL24F, VAL286E, VAL286F, VAL31E, VAL31F, VAL446E, VAL446F, VAL450E, VAL450F, VAL491E, VAL491F, VAL547E, VAL547F, VAL75E, VAL75F
• E-G: ALA135E, ALA135G, ALA141E, ALA141G, ALA144E, ALA144G, ALA146E, ALA146G, ALA167E, ALA167G, ARG129E, ARG129G, ASN102E, ASN102G, ASN104E, ASN104G, ASN169E, ASN169G, ASP105E, ASP105G, ASP120E, ASP120G, ASP140E, ASP140G, GLN106E, GLN106G, GLN130E, GLN130G, GLU126E, GLU126G, GLU136E, GLU136G, GLY107E, GLY107G, GLY109E, GLY109G, HIS110E, HIS110G, HIS142E, HIS142G, HIS150E, HIS150G, ILE111E, ILE111G, ILE116E, ILE116G, ILE138E, ILE138G, ILE170E, ILE170G, LEU125E, LEU125G, LYS118E, LYS118G, LYS147E, LYS147G, SER103E, SER103G, SER122E, SER122G, SER137E, SER137G, SER143E, SER143G, THR108E, THR108G, THR119E, THR119G, THR139E, THR139G, TYR121E, TYR121G, TYR123E, TYR123G
• E-H: ALA144E, ALA144H, ALA146E, ALA146H, ALA197E, ALA197H, ALA198E, ALA198H, ALA201E, ALA201H, ALA318E, ALA318H, ARG129E, ARG129H, ARG12E, ARG12H, ARG153E, ARG153H, ARG157E, ARG157H, ARG177E, ARG177H, ARG311E, ARG311H, ARG317E, ARG317H, ASP140E, ASP140H, ASP149E, ASP149H, ASP191E, ASP191H, ASP310E, ASP310H, ASP315E, ASP315H, ASP320E, ASP320H, CYS133E, CYS133H, CYS175E, CYS175H, GLN130E, GLN130H, GLN15E, GLN15H, GLU11E, GLU11H, GLU126E, GLU126H, GLU136H, GLU158E, GLU158H, GLU187E, GLU187H, GLU189E, GLU189H, GLU308E, GLU308H, GLY179E, GLY179H, GLY301E, GLY301H, GLY316E, GLY316H, GLY321E, GLY321H, HIS142E, HIS142H, HIS150E, HIS150H, HIS192E, HIS192H, ILE148E, ILE148H, ILE152E, ILE152H, ILE190E, ILE190H, LEU184E, LEU184H, LEU185E, LEU185H, LEU195E, LEU195H, LEU306E, LEU306H, LYS147E, LYS147H, LYS196E, LYS196H, LYS300E, LYS300H, PHE322E, PHE322H, PRO145E, PRO145H, PRO178E, PRO178H, PRO180E, PRO180H, PRO188E, PRO188H, PRO302E, PRO302H, SER143E, SER143H, SER182E, SER182H, SER183E, SER183H, SER186E, SER186H, SER194E, SER194H, THR132E, THR132H, THR154E, THR154H, THR193E, THR193H, THR313E, THR313H, THR323E, THR323H, TRP298E, TRP298H, TYR319E, TYR319H, TYR3E, TYR3H, TYR88E, TYR88H, TYR8E, TYR8H, VAL131E, VAL131H, VAL176E, VAL176H, VAL181E, VAL181H, VAL312E, VAL312H, VAL314E, VAL314H
• F-G: ALA144F, ALA144G, ALA146F, ALA146G, ALA197F, ALA197G, ALA198F, ALA198G, ALA201F, ALA201G, ALA318F, ALA318G, ARG129F, ARG129G, ARG12F, ARG12G, ARG153F, ARG153G, ARG157F, ARG157G, ARG177F, ARG177G, ARG311F, ARG311G, ARG317F, ARG317G, ASP140F, ASP140G, ASP149F, ASP149G, ASP191F, ASP191G, ASP310F, ASP310G, ASP315F, ASP315G, ASP320F, ASP320G, CYS133F, CYS133G, CYS175F, CYS175G, GLN130F, GLN130G, GLN15F, GLN15G, GLU11F, GLU11G, GLU126F, GLU126G, GLU158F, GLU158G, GLU187F, GLU187G, GLU189F, GLU189G, GLU308F, GLU308G, GLY179F, GLY179G, GLY301F, GLY301G, GLY316F, GLY316G, GLY321F, GLY321G, HIS142F, HIS142G, HIS150F, HIS150G, HIS192F, HIS192G, ILE148F, ILE148G, ILE152F, ILE152G, ILE190F, ILE190G, LEU184F, LEU184G, LEU185F, LEU185G, LEU195F, LEU195G, LEU306F, LEU306G, LYS147F, LYS147G, LYS196F, LYS196G, LYS300F, LYS300G, PHE322F, PHE322G, PRO145F, PRO145G, PRO178F, PRO178G, PRO180F, PRO180G, PRO188F, PRO188G, PRO302F, PRO302G, SER143F, SER143G, SER182F, SER182G, SER183F, SER183G, SER186F, SER186G, SER194F, SER194G, THR132F, THR132G, THR154F, THR154G, THR193F, THR193G, THR313F, THR313G, THR323F, THR323G, TRP298F, TRP298G, TYR319F, TYR319G, TYR3F, TYR3G, TYR88F, TYR88G, TYR8F, TYR8G, VAL131F, VAL131G, VAL176F, VAL176G, VAL181F, VAL181G, VAL312F, VAL312G, VAL314F, VAL314G
• F-H: ALA135F, ALA135H, ALA141F, ALA141H, ALA144F, ALA144H, ALA146F, ALA146H, ALA167F, ALA167H, ARG129F, ARG129H, ASN102F, ASN102H, ASN104F, ASN104H, ASN169F, ASN169H, ASP105F, ASP105H, ASP120F, ASP120H, ASP140F, ASP140H, ASP165F, GLN106F, GLN106H, GLN130F, GLN130H, GLU126F, GLU126H, GLU136F, GLU136H, GLY107F, GLY107H, GLY109F, GLY109H, HIS110F, HIS110H, HIS142F, HIS142H, HIS150F, HIS150H, ILE111F, ILE111H, ILE116F, ILE116H, ILE138F, ILE138H, ILE170F, ILE170H, LEU125F, LEU125H, LYS118F, LYS118H, LYS147F, LYS147H, SER103F, SER103H, SER122F, SER122H, SER137F, SER137H, SER143F, SER143H, THR108F, THR108H, THR119F, THR119H, THR139F, THR139H, TYR121F, TYR121H, TYR123F, TYR123H
• G-H: ALA100G, ALA100H, ALA128G, ALA128H, ALA141G, ALA171G, ALA171H, ALA23G, ALA23H, ALA25G, ALA25H, ALA443G, ALA443H, ALA447G, ALA447H, ALA486G, ALA486H, ALA494G, ALA494H, ALA548G, ALA548H, ALA552G, ALA552H, ALA77G, ALA77H, ALA80G, ALA80H, ALA83G, ALA83H, ALA87G, ALA87H, ALA89G, ALA89H, ARG129G, ARG129H, ARG451G, ARG451H, ARG464G, ARG464H, ARG553G, ARG553H, ASN102G, ASN102H, ASN104G, ASN104H, ASN169G, ASN169H, ASN288G, ASN288H, ASN29G, ASN29H, ASN462G, ASN462H, ASN478G, ASN478H, ASN482G, ASN482H, ASN493G, ASN493H, ASN49G, ASN49H, ASN52G, ASN52H, ASN551G, ASN551H, ASN82G, ASN82H, ASN91G, ASN91H, ASP105G, ASP105H, ASP27G, ASP27H, ASP289G, ASP289H, ASP34G, ASP34H, ASP474G, ASP474H, ASP484G, ASP484H, CYS133G, CYS133H, CYS168G, CYS168H, CYS47G, CYS47H, CYS48G, CYS48H, GLN106G, GLN106H, GLN124G, GLN124H, GLN130G, GLN130H, GLN35G, GLN35H, GLN407G, GLN407H, GLN440G, GLN440H, GLN444G, GLN444H, GLN448G, GLN448H, GLN44G, GLN44H, GLN530G, GLN530H, GLU126G, GLU126H, GLU158G, GLU158H, GLU173G, GLU173H, GLU308G, GLU308H, GLU405G, GLU405H, GLU445G, GLU445H, GLU453G, GLU453H, GLU469G, GLU469H, GLU490G, GLU490H, GLU496G, GLU496H, GLU50G, GLU50H, GLU528G, GLU528H, GLU90G, GLU90H, GLY109G, GLY109H, GLY117G, GLY117H, GLY26G, GLY26H, GLY294H, GLY409G, GLY409H, GLY412G, GLY412H, GLY437G, GLY437H, GLY475G, GLY475H, GLY487G, GLY487H, GLY495G, GLY495H, GLY497G, GLY497H, GLY499G, GLY499H, GLY76G, GLY76H, GLY85G, GLY85H, GLY86G, GLY86H, HIS110G, HIS110H, HIS113G, HIS113H, HIS114G, HIS114H, HIS21G, HIS21H, HIS410G, HIS410H, HIS473G, HIS473H, HIS498G, HIS498H, ILE111G, ILE111H, ILE116G, ILE116H, ILE170G, ILE170H, ILE411G, ILE411H, ILE45G, ILE45H, ILE468G, ILE468H, ILE470G, ILE470H, ILE472G, ILE472H, ILE480G, ILE480H, ILE78G, ILE78H, LEU112G, LEU112H, LEU125G, LEU125H, LEU30G, LEU30H, LEU32G, LEU32H, LEU33G, LEU33H, LEU36G, LEU36H, LEU37G, LEU37H, LEU441G, LEU441H, LEU488G, LEU488H, LEU51G, LEU51H, LEU84G, LEU84H, LYS118G, LYS118H, LYS160G, LYS160H, LYS219G, LYS219H, LYS300G, LYS300H, LYS40G, LYS40H, LYS481G, LYS481H, LYS503G, LYS503H, LYS554G, LYS554H, MET127G, MET127H, MET406G, MET406H, MET449G, MET449H, MET489G, MET489H, MET81G, MET81H, PHE287G, PHE287H, PHE439G, PHE439H, PHE492G, PHE492H, PHE55G, PHE55H, PHE73G, PHE73H, PRO101G, PRO101H, PRO161G, PRO161H, PRO174G, PRO174H, PRO285G, PRO285H, PRO476G, PRO476H, SER103G, SER103H, SER122G, SER122H, SER172G, SER172H, SER291G, SER291H, SER438G, SER438H, SER549G, SER549H, SER74G, SER74H, SER79G, SER79H, THR108G, THR108H, THR115G, THR115H, THR132G, THR132H, THR292G, THR292H, THR384G, THR384H, THR442G, THR442H, THR4G, THR4H, THR550G, THR550H, THR555G, THR555H, THR72G, THR72H, TRP295G, TRP295H, TRP298G, TRP298H, TRP388G, TRP388H, TRP408G, TRP408H, TRP413G, TRP413H, TRP483G, TRP483H, TRP543G, TRP543H, TYR121G, TYR121H, TYR123G, TYR123H, TYR28G, TYR28H, TYR290G, TYR290H, TYR452G, TYR452H, TYR466G, TYR466H, TYR46G, TYR46H, TYR477G, TYR477H, TYR479G, TYR479H, TYR485G, TYR485H, TYR88G, TYR88H, VAL131G, VAL131H, VAL24G, VAL24H, VAL286G, VAL286H, VAL31G, VAL31H, VAL446G, VAL446H, VAL450G, VAL450H, VAL491G, VAL491H, VAL547G, VAL547H, VAL75G, VAL75H