2VAX

crystal structure of deacetylcephalosporin c acetyltransferase (cephalosporin c-soak)

• Total interactions analyzed: 66
• Total true interactions: 19
• Strongest Interaction:
  • Chains: F-H
  • Int. Res.: 172
  • Norm. En. per Res.: -4.1088
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-22.3855	8.6002	-172.831	-186.6163	97	11	8	8324	0	33	35
A-C	0.0	1.4812	-35.4391	-33.9579	47	1	1	2279	0	21	22
A-E	0.0	0.0	-0.0471	-0.0471	5	0	0	30	0	0	0
A-I	-78.7405	-108.9358	-562.696	-750.3724	192	16	15	22122	13	63	60
A-K	-27.4885	27.9912	-67.5707	-67.068	36	5	1	2891	0	13	14
B-C	-14.5354	2.0933	-63.0227	-75.4648	68	1	1	3691	4	28	19
B-E	-79.0169	-108.8107	-565.304	-753.1316	192	17	15	22175	14	63	61
B-F	-12.8153	-23.082	-48.2327	-84.13	55	3	0	2149	0	13	10
B-I	0.0	0.0	-0.0925	-0.0925	4	0	0	46	0	0	0
C-F	-22.1993	7.0041	-123.127	-138.3222	71	9	0	5724	0	20	25
C-J	-67.7628	-102.2492	-498.318	-668.33	169	9	13	19467	14	65	61
D-I	-23.6171	39.6789	-67.9552	-51.8934	49	8	0	3004	0	20	18
D-K	-66.7446	-103.1002	-511.197	-681.0418	171	12	13	19822	14	65	61
D-L	0.0	0.0	-0.0793	-0.0793	2	0	0	24	0	0	3
E-G	0.0	9.9504	-23.386	-13.4356	42	0	0	1673	0	7	8
F-H	-64.1845	-122.827	-519.709	-706.7205	172	11	14	19987	14	62	61
G-L	-64.3216	-118.201	-507.2	-689.7225	171	9	14	19721	14	63	61
I-K	0.0	11.144	-10.3794	0.7646	20	4	0	826	0	10	7
I-L	-12.7264	-22.7222	-48.1949	-83.6435	53	3	0	2131	0	13	10

Interface residues

• A-B: ALA159A, ALA159B, ALA311A, ALA311B, ARG120A, ARG120B, ARG124A, ARG124B, ARG128A, ARG128B, ARG131A, ARG131B, ARG136A, ARG136B, ARG140A, ARG308A, ARG308B, ARG310A, ARG310B, ARG33A, ARG33B, ASP107B, ASP125A, ASP125B, ASP135A, ASP135B, ASP305A, ASP305B, ASP34A, ASP34B, GLN132A, GLN132B, GLN141A, GLN323A, GLN323B, GLU157A, GLU157B, GLU164A, GLU164B, GLU27A, GLU27B, GLY162A, GLY162B, GLY29A, GLY29B, GLY309A, GLY309B, ILE129B, ILE142A, ILE142B, ILE21A, ILE21B, ILE306A, ILE306B, ILE31A, ILE31B, ILE321A, ILE321B, LEU23A, LEU23B, LEU26A, LEU26B, LEU32A, LEU32B, MET320A, MET320B, PHE160A, PHE160B, PHE161A, PHE161B, PHE24A, PHE24B, PRO106A, PRO119A, PRO119B, PRO163A, PRO163B, SER22A, SER22B, SER28A, SER28B, SER307A, SER307B, THR25A, THR25B, THR322A, THR322B, TRP158A, TRP158B, TYR165A, TYR165B, VAL127A, VAL127B, VAL166A, VAL166B, VAL30A, VAL30B
• A-C: ALA19A, ARG124C, ARG128C, ARG131C, ARG136A, ARG136C, ARG140A, ARG140C, ARG20A, ARG310C, ARG33C, ARG44A, ARG49A, ASN46A, ASP135A, ASP135C, ASP17A, ASP34C, ASP50A, GLN132A, GLN132C, GLU164A, GLU27C, GLY138A, GLY29C, ILE129C, ILE18A, ILE21C, ILE31C, LEU134A, LEU137A, LEU23C, LEU26C, MET45A, PHE160C, PHE161C, PHE24C, SER22C, SER28C, SER48A, THR25C, TYR165C, TYR39A, VAL127C, VAL133A, VAL139A, VAL47A
• A-E: ARG120A, GLY240E, SER28A, VAL241E, VAL30A
• A-I: ALA183A, ALA183I, ALA184A, ALA184I, ALA217A, ALA217I, ALA221A, ALA221I, ALA230A, ALA230I, ALA238A, ALA238I, ALA273A, ALA273I, ALA282A, ALA282I, ALA311A, ALA311I, ALA317A, ALA317I, ARG120A, ARG120I, ARG124A, ARG124I, ARG177A, ARG177I, ARG190A, ARG190I, ARG212A, ARG212I, ARG218A, ARG218I, ARG234A, ARG234I, ARG279A, ARG279I, ARG308A, ARG308I, ARG310A, ARG310I, ASN222A, ASN222I, ASP195A, ASP195I, ASP196A, ASP196I, ASP232A, ASP232I, ASP302A, ASP302I, ASP305A, ASP305I, ASP333A, ASP333I, ASP339A, ASP339I, CYS176I, CYS182A, CYS182I, CYS192A, CYS192I, GLN178A, GLN178I, GLN189A, GLN189I, GLN191A, GLN191I, GLN269A, GLN269I, GLN283A, GLN283I, GLU187A, GLU187I, GLU215A, GLU215I, GLU233A, GLU233I, GLU272A, GLU272I, GLU316A, GLU316I, GLU340A, GLU340I, GLY180A, GLY180I, GLY213A, GLY213I, GLY240A, GLY240I, GLY309A, GLY309I, GLY312A, GLY312I, GLY334A, GLY334I, GLY361A, GLY361I, HIS236A, HIS236I, HIS304A, HIS304I, HIS341A, HIS341I, HIS362A, HIS362I, ILE193A, ILE193I, ILE220A, ILE220I, ILE271A, ILE271I, ILE306A, ILE306I, ILE314A, ILE314I, LEU223A, LEU223I, LEU278A, LEU278I, LEU335A, LEU335I, LYS219A, LYS219I, LYS226A, LYS226I, LYS228A, LYS228I, MET231A, MET231I, MET237A, MET237I, PHE186A, PHE186I, PHE235A, PHE235I, PHE301A, PHE301I, PHE338A, PHE338I, PRO197A, PRO197I, PRO229A, PRO229I, PRO239A, PRO239I, PRO270A, PRO270I, SER175A, SER175I, SER179A, SER179I, SER227A, SER227I, SER275A, SER275I, SER276A, SER276I, SER307A, SER307I, SER313A, SER313I, SER332I, SER337A, SER337I, THR174A, THR174I, THR188A, THR188I, THR216A, THR216I, THR224A, THR224I, THR303A, THR303I, TRP181A, TRP181I, TRP185A, TRP185I, TYR194A, TYR194I, TYR225A, TYR225I, TYR277A, TYR277I, TYR280A, TYR280I, TYR336A, TYR336I, VAL241A, VAL241I, VAL274A, VAL274I
• A-K: ALA325K, ALA375A, ALA375K, ARG331A, ARG346A, ARG352A, ARG352K, ARG377K, ARG83K, ASN350K, ASP357A, ASP374K, ASP381K, CYS329A, CYS354A, GLN382K, GLY345A, GLY378K, ILE327A, ILE328A, LEU326A, LEU326K, LEU353A, LEU380K, LEU384K, LYS168K, LYS371A, PHE338A, PHE379K, PRO324K, SER351A, SER351K, SER383K, VAL342A, VAL355A, VAL356A
• B-C: ALA11B, ALA11C, ALA15B, ALA15C, ALA19B, ALA19C, ALA6B, ALA6C, ARG136B, ARG136C, ARG140B, ARG140C, ARG20B, ARG20C, ARG44B, ARG44C, ARG49B, ARG49C, ASN46B, ASN46C, ASN7C, ASP135B, ASP135C, ASP14B, ASP14C, ASP17B, ASP17C, ASP34B, ASP34C, ASP50B, GLN111C, GLN132B, GLN16B, GLN16C, GLN4C, GLU109C, GLU10B, GLU10C, GLY110C, GLY138B, GLY138C, ILE18B, ILE18C, ILE21B, ILE21C, ILE5C, LEU137B, LEU137C, LEU13B, LEU13C, MET45B, MET45C, PRO104B, PRO104C, PRO106B, PRO36B, PRO36C, SER12C, SER22B, SER48B, TYR39B, TYR39C, VAL133C, VAL139B, VAL139C, VAL35B, VAL47B, VAL47C
• B-E: ALA183B, ALA183E, ALA184B, ALA184E, ALA217B, ALA217E, ALA221B, ALA221E, ALA230B, ALA230E, ALA238B, ALA238E, ALA273B, ALA273E, ALA282B, ALA282E, ALA311B, ALA311E, ALA317B, ALA317E, ARG120B, ARG120E, ARG124B, ARG124E, ARG177B, ARG177E, ARG190B, ARG190E, ARG212B, ARG212E, ARG218B, ARG218E, ARG234B, ARG234E, ARG279B, ARG279E, ARG308B, ARG308E, ARG310B, ARG310E, ASN222B, ASN222E, ASP195B, ASP195E, ASP196B, ASP196E, ASP232B, ASP232E, ASP302B, ASP302E, ASP305B, ASP305E, ASP333B, ASP333E, ASP339B, ASP339E, CYS176B, CYS182B, CYS182E, CYS192B, CYS192E, GLN178B, GLN178E, GLN189B, GLN189E, GLN191B, GLN191E, GLN269B, GLN269E, GLN283B, GLN283E, GLU187B, GLU187E, GLU215B, GLU215E, GLU233B, GLU233E, GLU272B, GLU272E, GLU316B, GLU316E, GLU340B, GLU340E, GLY180B, GLY180E, GLY213B, GLY213E, GLY240B, GLY240E, GLY309B, GLY309E, GLY312B, GLY312E, GLY334B, GLY334E, GLY361B, GLY361E, HIS236B, HIS236E, HIS304B, HIS304E, HIS341B, HIS341E, HIS362B, HIS362E, ILE193B, ILE193E, ILE220B, ILE220E, ILE271B, ILE271E, ILE306B, ILE306E, ILE314B, ILE314E, LEU223B, LEU223E, LEU278B, LEU278E, LEU335B, LEU335E, LYS219B, LYS219E, LYS226B, LYS226E, LYS228B, LYS228E, MET231B, MET231E, MET237B, MET237E, PHE186B, PHE186E, PHE235B, PHE235E, PHE301B, PHE301E, PHE338B, PHE338E, PRO197B, PRO197E, PRO229B, PRO229E, PRO239B, PRO239E, PRO270B, PRO270E, SER175B, SER175E, SER179B, SER179E, SER227B, SER227E, SER275B, SER275E, SER276B, SER276E, SER307B, SER307E, SER313B, SER313E, SER332B, SER337B, SER337E, THR174B, THR174E, THR188B, THR188E, THR216B, THR216E, THR224B, THR224E, THR303B, THR303E, TRP181B, TRP181E, TRP185B, TRP185E, TYR194B, TYR194E, TYR225B, TYR225E, TYR277B, TYR277E, TYR280B, TYR280E, TYR336B, TYR336E, VAL241B, VAL241E, VAL274B, VAL274E
• B-F: ALA11B, ALA11F, ALA15B, ALA15F, ALA38B, ALA6B, ARG20F, ARG44B, ARG44F, ARG49F, ARG83F, ARG8B, ARG8F, ASN46F, ASN51F, ASN7B, ASP14B, ASP14F, ASP17B, ASP17F, GLN16B, GLN75B, GLN75F, GLU10B, GLY43B, GLY43F, GLY74B, GLY97B, HIS64B, ILE18B, LEU13B, LEU13F, LYS284B, LYS40B, LYS40F, MET45F, PHE73B, PHE85F, PHE96B, PHE9B, SER12B, SER12F, SER288B, SER41F, SER62B, SER82B, SER82F, THR66B, THR81B, THR81F, TRP42B, TRP42F, TYR280B, TYR39B, VAL47F
• B-I: ARG120B, SER28B, VAL241I, VAL30B
• C-F: ALA15C, ALA19F, ARG131F, ARG136F, ARG140F, ARG20F, ARG33F, ARG44C, ARG44F, ARG49F, ARG77C, ARG83C, ASN46C, ASN46F, ASN51C, ASP107F, ASP135F, ASP14C, ASP34F, ASP50F, ASP80C, GLN132F, GLN141F, GLN75C, GLU164F, GLY138F, GLY43C, GLY43F, GLY74C, GLY76C, HIS64C, ILE18F, ILE21F, ILE86C, LEU134F, LEU137F, LEU13C, LEU23F, LEU72C, LYS284C, LYS40C, MET45C, MET45F, PHE24F, PHE73C, PHE79C, PHE85C, PHE85F, PRO106F, PRO70C, SER12C, SER22F, SER41C, SER48F, SER67C, SER82C, THR66C, THR71C, THR81C, TRP42C, TRP68C, TRP69C, TYR165F, TYR280C, TYR84C, VAL133F, VAL139F, VAL366C, VAL47C, VAL47F, VAL65C
• C-J: ALA183C, ALA183J, ALA184C, ALA184J, ALA217C, ALA217J, ALA221C, ALA221J, ALA230C, ALA230J, ALA273C, ALA273J, ALA282C, ALA282J, ARG120C, ARG120J, ARG177C, ARG177J, ARG190C, ARG190J, ARG212C, ARG212J, ARG218C, ARG218J, ARG234C, ARG234J, ARG279C, ARG279J, ARG308C, ARG308J, ASN222C, ASN222J, ASP195C, ASP195J, ASP196C, ASP196J, ASP232C, ASP232J, ASP302C, ASP302J, ASP305C, ASP305J, ASP333C, ASP333J, ASP339C, ASP339J, CYS182C, CYS182J, CYS192C, CYS192J, GLN178C, GLN178J, GLN189C, GLN189J, GLN191C, GLN191J, GLN269C, GLN269J, GLN283C, GLN283J, GLU187C, GLU187J, GLU215C, GLU215J, GLU233C, GLU233J, GLU272C, GLU272J, GLU340C, GLU340J, GLY180C, GLY180J, GLY213C, GLY213J, GLY334C, GLY334J, GLY361C, GLY361J, HIS236C, HIS236J, HIS304C, HIS304J, HIS341C, HIS341J, HIS362C, HIS362J, ILE193C, ILE193J, ILE220C, ILE220J, ILE271C, ILE271J, ILE306C, ILE306J, ILE314C, ILE314J, LEU223C, LEU223J, LEU278C, LEU278J, LEU335C, LEU335J, LYS198C, LYS198J, LYS219C, LYS219J, LYS226C, LYS226J, LYS228C, LYS228J, MET231C, MET231J, MET237C, MET237J, PHE186C, PHE186J, PHE235C, PHE235J, PHE301C, PHE301J, PHE338C, PHE338J, PRO197C, PRO197J, PRO229C, PRO229J, PRO270C, PRO270J, SER175C, SER175J, SER179C, SER179J, SER227C, SER227J, SER275C, SER275J, SER276C, SER276J, SER307J, SER332J, SER337C, SER337J, THR174C, THR188C, THR188J, THR216C, THR216J, THR224C, THR224J, THR303C, THR303J, TRP181C, TRP181J, TRP185C, TRP185J, TYR194C, TYR194J, TYR199C, TYR199J, TYR225C, TYR225J, TYR277C, TYR277J, TYR280C, TYR280J, TYR336C, TYR336J, VAL274C, VAL274J
• D-I: ALA330D, ALA375D, ALA375I, ARG331D, ARG346D, ARG352D, ARG352I, ARG377I, ARG77I, ARG83I, ASN350D, ASN350I, ASN373I, ASP357D, ASP370I, ASP374D, ASP374I, ASP381I, ASP80I, CYS329D, CYS354D, CYS354I, GLN382D, GLN382I, GLN75I, GLU368D, GLY378I, GLY76I, ILE327D, ILE328D, LEU326D, LEU326I, LEU353D, LEU380I, LYS168I, LYS371D, PHE338D, PHE379I, PRO324I, PRO349D, SER351D, SER383I, THR358D, TYR84I, VAL342D, VAL355D, VAL356D, VAL372D, VAL376I
• D-K: ALA183D, ALA183K, ALA184D, ALA184K, ALA217D, ALA217K, ALA221D, ALA221K, ALA230D, ALA230K, ALA273D, ALA273K, ALA282D, ALA282K, ARG120D, ARG120K, ARG177D, ARG177K, ARG190D, ARG190K, ARG212D, ARG212K, ARG218D, ARG218K, ARG234D, ARG234K, ARG279D, ARG279K, ARG308D, ARG308K, ASN222D, ASN222K, ASP195D, ASP195K, ASP196D, ASP196K, ASP232D, ASP232K, ASP302D, ASP302K, ASP305D, ASP305K, ASP333D, ASP333K, ASP339D, ASP339K, CYS182D, CYS182K, CYS192D, CYS192K, GLN178D, GLN178K, GLN189D, GLN189K, GLN191D, GLN191K, GLN269D, GLN269K, GLN283D, GLN283K, GLU187D, GLU187K, GLU215D, GLU215K, GLU233D, GLU233K, GLU272D, GLU272K, GLU340D, GLU340K, GLY180D, GLY180K, GLY213D, GLY213K, GLY334D, GLY334K, GLY361D, GLY361K, HIS236D, HIS236K, HIS304D, HIS304K, HIS341D, HIS341K, HIS362D, HIS362K, ILE193D, ILE193K, ILE220D, ILE220K, ILE271D, ILE271K, ILE306D, ILE306K, ILE314D, ILE314K, LEU223D, LEU223K, LEU278D, LEU278K, LEU299K, LEU335D, LEU335K, LYS198D, LYS198K, LYS219D, LYS219K, LYS226D, LYS226K, LYS228D, LYS228K, MET231D, MET231K, MET237D, MET237K, PHE186D, PHE186K, PHE235D, PHE235K, PHE301D, PHE301K, PHE338D, PHE338K, PRO197D, PRO197K, PRO229D, PRO229K, PRO270D, PRO270K, SER175D, SER175K, SER179D, SER179K, SER227D, SER227K, SER275D, SER275K, SER276D, SER276K, SER307K, SER332K, SER337D, SER337K, THR174D, THR174K, THR188D, THR188K, THR216D, THR216K, THR224D, THR224K, THR303D, THR303K, TRP181D, TRP181K, TRP185D, TRP185K, TYR194D, TYR194K, TYR199D, TYR199K, TYR225D, TYR225K, TYR277D, TYR277K, TYR280D, TYR280K, TYR336D, TYR336K, VAL274D, VAL274K
• D-L: ASP207L, THR322D
• E-G: ALA15E, ALA311G, ALA317G, ALA319G, ARG167G, ARG310G, ARG346G, ARG44E, ASN350G, ASP14E, GLN16E, GLN323G, GLN75E, GLU316G, GLY309G, GLY312G, GLY43E, GLY74E, HIS64E, ILE321G, ILE348G, LEU13E, LYS168G, LYS40E, MET320G, PHE160G, PHE73E, PRO163G, PRO324G, PRO349G, PRO70E, SER307G, SER313G, SER347G, SER351G, SER41E, SER67E, SER82E, THR322G, THR66E, THR81E, TRP42E
• F-H: ALA183F, ALA183H, ALA184F, ALA184H, ALA217F, ALA217H, ALA221F, ALA221H, ALA230F, ALA230H, ALA273F, ALA273H, ALA282F, ALA282H, ARG120F, ARG120H, ARG177F, ARG177H, ARG190F, ARG190H, ARG212F, ARG212H, ARG218F, ARG218H, ARG234F, ARG234H, ARG279F, ARG279H, ARG308F, ARG308H, ASN222F, ASN222H, ASP195F, ASP195H, ASP196F, ASP196H, ASP232F, ASP232H, ASP302F, ASP302H, ASP305F, ASP305H, ASP333F, ASP333H, ASP339F, ASP339H, CYS182F, CYS182H, CYS192F, CYS192H, GLN178F, GLN178H, GLN189F, GLN189H, GLN191F, GLN191H, GLN269F, GLN269H, GLN283F, GLN283H, GLU187F, GLU187H, GLU215F, GLU215H, GLU233F, GLU233H, GLU272F, GLU272H, GLU340F, GLU340H, GLY180F, GLY180H, GLY213F, GLY213H, GLY334F, GLY334H, GLY361F, GLY361H, HIS236F, HIS236H, HIS304F, HIS304H, HIS341F, HIS341H, HIS362F, HIS362H, ILE193F, ILE193H, ILE220F, ILE220H, ILE271F, ILE271H, ILE306F, ILE314F, ILE314H, LEU200H, LEU223F, LEU223H, LEU278F, LEU278H, LEU299F, LEU299H, LEU335F, LEU335H, LYS198F, LYS198H, LYS219F, LYS219H, LYS226F, LYS226H, LYS228F, LYS228H, MET231F, MET231H, MET237F, MET237H, PHE186F, PHE186H, PHE235F, PHE235H, PHE301F, PHE301H, PHE338F, PHE338H, PRO197F, PRO197H, PRO229F, PRO229H, PRO270F, PRO270H, SER175F, SER175H, SER179F, SER179H, SER227F, SER227H, SER275F, SER275H, SER276F, SER276H, SER307F, SER332F, SER332H, SER337F, SER337H, THR174F, THR188F, THR188H, THR216F, THR216H, THR224F, THR224H, THR303F, THR303H, TRP181F, TRP181H, TRP185F, TRP185H, TYR194F, TYR194H, TYR199F, TYR199H, TYR225F, TYR225H, TYR277F, TYR277H, TYR280F, TYR280H, TYR336F, TYR336H, VAL274F, VAL274H
• G-L: ALA183G, ALA183L, ALA184G, ALA184L, ALA217G, ALA217L, ALA221G, ALA221L, ALA230G, ALA230L, ALA273G, ALA273L, ALA282G, ALA282L, ARG120G, ARG120L, ARG177G, ARG177L, ARG190G, ARG190L, ARG212G, ARG212L, ARG218G, ARG218L, ARG234G, ARG234L, ARG279G, ARG279L, ARG308G, ARG308L, ASN222G, ASN222L, ASP195G, ASP195L, ASP196G, ASP196L, ASP232G, ASP232L, ASP302G, ASP302L, ASP305G, ASP305L, ASP333G, ASP333L, ASP339G, ASP339L, CYS182G, CYS182L, CYS192G, CYS192L, GLN178G, GLN178L, GLN189G, GLN189L, GLN191G, GLN191L, GLN269G, GLN283G, GLN283L, GLU187G, GLU187L, GLU215G, GLU215L, GLU233G, GLU233L, GLU272G, GLU272L, GLU340G, GLU340L, GLU360L, GLY180G, GLY180L, GLY213G, GLY213L, GLY334G, GLY334L, GLY361G, GLY361L, HIS236G, HIS236L, HIS304G, HIS304L, HIS341G, HIS341L, HIS362G, HIS362L, ILE193G, ILE193L, ILE220G, ILE220L, ILE271G, ILE271L, ILE306L, ILE314G, ILE314L, LEU223G, LEU223L, LEU278G, LEU278L, LEU299G, LEU299L, LEU335G, LEU335L, LYS198G, LYS198L, LYS219G, LYS219L, LYS226G, LYS226L, LYS228G, LYS228L, MET231G, MET231L, MET237G, MET237L, PHE186G, PHE186L, PHE235G, PHE235L, PHE301G, PHE301L, PHE338G, PHE338L, PRO197G, PRO197L, PRO229G, PRO229L, PRO270G, PRO270L, SER175G, SER175L, SER179G, SER179L, SER227G, SER227L, SER275G, SER275L, SER276G, SER276L, SER307L, SER332G, SER332L, SER337G, SER337L, THR174L, THR188G, THR188L, THR216G, THR216L, THR224G, THR224L, THR303G, THR303L, TRP181G, TRP181L, TRP185G, TRP185L, TYR194G, TYR194L, TYR199G, TYR199L, TYR225G, TYR225L, TYR277G, TYR277L, TYR280G, TYR280L, TYR336G, TYR336L, VAL274G, VAL274L
• I-K: ARG331I, ARG331K, ARG346I, ARG346K, ASP357I, CYS354I, GLU343I, GLU343K, GLY345I, GLY345K, LEU353I, LEU353K, PHE338I, PHE338K, SER347K, VAL342I, VAL342K, VAL355I, VAL355K, VAL356I
• I-L: ALA11I, ALA11L, ALA15I, ALA15L, ALA38I, ALA6I, ARG20L, ARG44I, ARG44L, ARG83L, ARG8I, ARG8L, ASN46L, ASN51L, ASN7I, ASP14I, ASP14L, ASP17I, ASP17L, GLN16I, GLN75I, GLN75L, GLU10I, GLY43I, GLY43L, GLY74I, GLY97I, HIS64I, ILE18I, LEU13I, LEU13L, LYS284I, LYS40I, LYS40L, MET45L, PHE73I, PHE85L, PHE96I, PHE9I, SER12I, SER12L, SER288I, SER41L, SER62I, SER82L, THR66I, THR81I, THR81L, TRP42I, TRP42L, TYR280I, TYR39I, VAL47L