2V9P

crystal structure of papillomavirus e1 hexameric helicase dna-free form

• Total interactions analyzed: 66
• Total true interactions: 26
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 169
  • Norm. En. per Res.: -3.5187
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-29.0863	-63.0516	-393.524	-485.662	178	24	8	17427	8	57	79
A-F	-22.3816	-59.73	-294.336	-376.4476	158	7	4	12745	4	49	74
A-G	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	1	1
A-H	0.0	0.0	-0.0322	-0.0322	5	0	0	20	0	2	2
B-C	-55.3566	-64.6621	-428.705	-548.7237	172	28	9	17732	7	49	74
B-F	0.0	0.0	-0.0078	-0.0078	2	0	0	5	0	0	2
B-H	0.0	-12.734	-7.7702	-20.5042	7	0	0	387	2	5	7
B-I	0.0	11.0397	-0.4269	10.6128	3	0	0	25	0	2	2
C-D	-77.5984	-85.2286	-431.838	-594.665	169	25	11	17420	9	49	77
C-I	0.0	5.5022	-1.2674	4.2347	11	0	0	193	0	7	10
C-J	0.0	0.0	-0.02	-0.02	3	0	0	5	0	2	2
D-E	-56.4556	-9.6366	-411.933	-478.0252	171	29	11	16690	6	50	73
D-K	0.0	0.0	-0.2331	-0.2331	5	0	0	46	0	1	3
D-L	0.0	0.0	-0.0317	-0.0317	3	0	0	7	0	1	0
E-F	-53.5199	-28.8088	-349.489	-431.8177	164	19	7	14620	4	44	59
E-G	0.0	0.0	-0.0014	-0.0014	2	0	0	1	0	2	2
E-L	0.0	0.0	-1.0892	-1.0892	15	0	0	160	0	7	6
F-G	0.0	-3.3664	-5.6983	-9.0647	10	0	0	421	0	5	6
G-H	-25.7126	-55.6646	-387.331	-468.7082	177	21	8	16691	6	53	74
G-L	-38.913	-61.5219	-325.92	-426.3549	158	18	5	13266	6	49	80
H-I	-69.6265	-72.4252	-440.033	-582.0847	170	18	11	17650	9	50	75
H-J	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	2
H-L	0.0	0.0	-0.0236	-0.0236	5	0	0	19	0	0	2
I-J	-68.1743	-64.2888	-424.309	-556.7721	167	28	10	17148	9	49	74
J-K	-64.2106	-20.5217	-405.386	-490.1183	170	31	11	16608	7	51	75
K-L	-29.8262	-19.2574	-379.041	-428.1246	160	18	9	15083	3	39	61

Interface residues

• A-B: ALA320B, ALA326A, ALA332A, ALA336A, ALA339A, ALA350A, ALA355A, ALA362A, ALA362B, ALA371B, ALA375B, ALA458A, ALA467A, ALA470B, ALA474A, ALA475A, ALA480A, ALA483A, ALA495B, ALA509B, ALA510B, ARG366A, ARG366B, ARG370B, ARG493B, ARG505B, ARG538B, ASN303A, ASN344B, ASN352A, ASN436A, ASN444A, ASN459A, ASN494B, ASN523A, ASN558A, ASP312B, ASP322B, ASP360B, ASP471B, ASP478A, ASP479A, ASP489B, ASP497B, ASP504B, ASP550A, ASP576B, CYS361B, CYS443A, CYS484A, GLN318B, GLN354A, GLN374B, GLN512B, GLN555A, GLU304A, GLU327A, GLU328A, GLU334A, GLU372B, GLU554A, GLY314B, GLY433A, GLY438A, GLY451A, GLY452A, GLY498B, HIS357A, HIS357B, HIS367B, HIS448A, HIS460A, HIS460B, HIS463B, HIS482A, HIS507A, HIS507B, HIS536B, ILE331A, ILE423B, ILE447A, ILE503B, ILE513B, ILE524A, LEU302A, LEU337A, LEU349A, LEU369B, LEU376B, LEU418B, LEU442A, LEU455A, LEU466B, LEU476A, LEU492B, LEU533B, LEU535B, LYS310B, LYS324B, LYS330A, LYS356A, LYS356B, LYS359A, LYS359B, LYS417B, LYS421B, LYS425B, LYS426B, LYS439A, LYS461A, LYS461B, LYS506A, LYS506B, LYS508B, LYS514B, MET316A, MET316B, MET364B, MET441A, PHE311B, PHE313B, PHE348A, PHE348B, PHE457A, PHE464A, PHE464B, PHE488B, PHE557A, PRO424B, PRO434A, PRO435A, PRO500B, PRO556A, SER305A, SER329A, SER353A, SER353B, SER440A, SER445A, SER453A, SER456A, SER462A, SER462B, SER468A, SER502B, SER522A, SER537B, THR301A, THR315B, THR351A, THR351B, THR363A, THR363B, THR373B, THR437A, THR472A, THR481A, THR490B, THR521A, THR549A, TRP319B, TRP465A, TRP465B, TYR321B, TYR333A, TYR335A, TYR368B, TYR487B, TYR491B, TYR499B, TYR534B, VAL317B, VAL358A, VAL365B, VAL454A, VAL477A, VAL501B, VAL511B
• A-F: ALA320A, ALA326F, ALA332F, ALA336F, ALA350F, ALA355F, ALA362F, ALA371A, ALA375A, ALA458F, ALA467F, ALA470A, ALA480F, ALA483A, ALA509A, ALA510A, ARG366A, ARG366F, ARG370A, ARG385F, ARG486A, ARG493A, ARG505A, ARG505F, ARG538A, ASN303F, ASN344A, ASN352F, ASN436F, ASN444F, ASN459F, ASN494A, ASN523F, ASN558F, ASP312A, ASP322A, ASP360A, ASP471A, ASP478F, ASP479F, ASP489A, ASP497A, ASP504A, ASP561F, CYS361A, CYS443F, GLN318A, GLN354F, GLN374A, GLN512A, GLU304F, GLU327F, GLU328F, GLU334F, GLU372A, GLY314A, GLY438F, GLY451F, GLY452F, GLY498A, HIS357A, HIS357F, HIS367A, HIS448F, HIS460A, HIS463A, HIS463F, HIS507A, HIS507F, ILE331F, ILE447F, ILE513A, ILE559F, LEU302F, LEU337F, LEU349F, LEU369A, LEU376A, LEU442F, LEU446F, LEU455F, LEU476F, LEU492A, LEU533A, LYS310A, LYS330F, LYS356A, LYS356F, LYS359A, LYS359F, LYS426A, LYS439F, LYS461A, LYS461F, LYS506F, LYS508A, LYS508F, LYS514A, MET316A, MET364A, MET441F, PHE311A, PHE313A, PHE348F, PHE449F, PHE457A, PHE457F, PHE464A, PHE464F, PHE488A, PRO424A, PRO435F, PRO500A, SER305F, SER329F, SER353A, SER353F, SER440F, SER445F, SER453F, SER456F, SER462A, SER462F, SER468F, SER502A, SER522F, SER537A, THR301F, THR315A, THR351A, THR351F, THR363A, THR363F, THR373A, THR437F, THR472F, THR481F, THR490A, THR521F, THR549F, THR560F, TRP319A, TRP465F, TRP564F, TYR321A, TYR333F, TYR335F, TYR368A, TYR487A, TYR491A, TYR499A, TYR534A, VAL317A, VAL358F, VAL365A, VAL454F, VAL501A, VAL511A
• A-G: LYS310A, PRO434G
• A-H: ALA350A, ASP530H, LEU533H, LYS310A, THR351A
• B-C: ALA320C, ALA326B, ALA332B, ALA336B, ALA339B, ALA350B, ALA355B, ALA362B, ALA371C, ALA375C, ALA458B, ALA467B, ALA470C, ALA474B, ALA475B, ALA480B, ALA483B, ALA495C, ALA509C, ALA510C, ARG366B, ARG366C, ARG370C, ARG486B, ARG486C, ARG493C, ARG505B, ARG505C, ARG538C, ASN303B, ASN344C, ASN352B, ASN436B, ASN444B, ASN459B, ASN494C, ASN523B, ASN558B, ASP312C, ASP322C, ASP360C, ASP471C, ASP478B, ASP479B, ASP489C, ASP497C, ASP504C, CYS361C, CYS484B, GLN318C, GLN354B, GLN374C, GLN512C, GLU304B, GLU327B, GLU328B, GLU334B, GLU372C, GLY314C, GLY433B, GLY438B, GLY451B, GLY452B, GLY498C, HIS357B, HIS357C, HIS367C, HIS448B, HIS460B, HIS460C, HIS463B, HIS463C, HIS482B, HIS507B, HIS507C, HIS536C, ILE331B, ILE423C, ILE447B, ILE503C, ILE513C, ILE524B, LEU302B, LEU337B, LEU349B, LEU369C, LEU376C, LEU442B, LEU455B, LEU466C, LEU476B, LEU492C, LEU533C, LEU535C, LYS310C, LYS324C, LYS330B, LYS356B, LYS356C, LYS359B, LYS359C, LYS425C, LYS426C, LYS439B, LYS461B, LYS461C, LYS506B, LYS506C, LYS508B, LYS508C, LYS514C, MET316B, MET316C, MET364C, MET441B, PHE311C, PHE313C, PHE348B, PHE457B, PHE464B, PHE464C, PHE488C, PRO424C, PRO434B, PRO435B, PRO500C, PRO556B, SER305B, SER329B, SER353B, SER353C, SER440B, SER445B, SER453B, SER456B, SER462B, SER462C, SER468B, SER502C, SER522B, SER537C, THR301B, THR315C, THR351B, THR351C, THR363C, THR373C, THR472B, THR481B, THR490C, THR521B, THR549B, TRP319C, TRP465B, TRP465C, TYR321C, TYR333B, TYR335B, TYR335C, TYR368C, TYR487B, TYR487C, TYR491C, TYR499C, TYR534C, VAL317C, VAL358B, VAL365C, VAL454B, VAL477B, VAL501C, VAL511C
• B-F: LYS461F, TYR491B
• B-H: ALA528H, ARG531H, ASP525H, ASP530H, GLN527H, GLU529H, LYS310B
• B-I: ASP530I, GLU304B, SER305B
• C-D: ALA320D, ALA326C, ALA332C, ALA336C, ALA350C, ALA355C, ALA362C, ALA371D, ALA375D, ALA458C, ALA467C, ALA470D, ALA475C, ALA480C, ALA483C, ALA495D, ALA509D, ALA510D, ARG366C, ARG366D, ARG370D, ARG486C, ARG486D, ARG493D, ARG505D, ARG538D, ASN303C, ASN344D, ASN352C, ASN436C, ASN444C, ASN459C, ASN494D, ASN523C, ASN558C, ASP312D, ASP322D, ASP360D, ASP471D, ASP478C, ASP479C, ASP489D, ASP497D, ASP504D, CYS361D, CYS484C, GLN318D, GLN354C, GLN374D, GLN512D, GLU304C, GLU327C, GLU328C, GLU334C, GLU372D, GLY314D, GLY433C, GLY438C, GLY451C, GLY452C, GLY498D, HIS323D, HIS357C, HIS357D, HIS367D, HIS448C, HIS460C, HIS460D, HIS463C, HIS463D, HIS482C, HIS507C, HIS507D, HIS536D, ILE331C, ILE423D, ILE447C, ILE503D, ILE513D, ILE524C, LEU302C, LEU337C, LEU349C, LEU369D, LEU376D, LEU418D, LEU442C, LEU455C, LEU466C, LEU466D, LEU476C, LEU492D, LEU533D, LEU535D, LYS310D, LYS324D, LYS330C, LYS356C, LYS356D, LYS359C, LYS359D, LYS425D, LYS426D, LYS439C, LYS461C, LYS461D, LYS506C, LYS506D, LYS508C, LYS508D, LYS514D, MET316C, MET316D, MET364D, MET441C, PHE311D, PHE313D, PHE348C, PHE457C, PHE464C, PHE464D, PHE488D, PRO424D, PRO434C, PRO435C, PRO500D, PRO556C, SER305C, SER329C, SER353C, SER440C, SER445C, SER453C, SER456C, SER462C, SER462D, SER468C, SER502D, SER522C, SER537D, THR301C, THR315D, THR351C, THR351D, THR363D, THR373D, THR472C, THR481C, THR490D, THR521C, TRP319D, TRP465C, TRP465D, TYR321D, TYR333C, TYR335C, TYR368D, TYR487C, TYR487D, TYR491D, TYR499D, TYR534D, VAL317D, VAL358C, VAL365D, VAL454C, VAL477C, VAL501D, VAL511D
• C-I: ALA347C, ARG346C, ARG531I, ASN344C, ASP312C, ASP530I, GLU529I, HIS482I, LYS310C, SER343C, THR315C
• C-J: ARG531J, GLU304C, SER305C
• D-E: ALA320E, ALA332D, ALA336D, ALA350D, ALA355D, ALA362E, ALA371E, ALA375E, ALA458D, ALA467D, ALA470E, ALA475D, ALA480D, ALA483D, ALA509E, ALA510E, ARG366D, ARG366E, ARG370E, ARG486E, ARG493E, ARG505D, ARG505E, ARG538E, ASN303D, ASN344E, ASN352D, ASN436D, ASN444D, ASN459D, ASN494E, ASN523D, ASN558D, ASP312E, ASP322E, ASP360E, ASP471E, ASP478D, ASP479D, ASP489E, ASP497E, ASP504E, CYS361E, CYS443D, CYS484D, CYS548D, GLN318E, GLN354D, GLN374E, GLN512E, GLN555D, GLU304D, GLU327D, GLU328D, GLU334D, GLU372E, GLU551D, GLU554D, GLY314E, GLY433D, GLY438D, GLY451D, GLY452D, GLY498E, GLY553D, HIS357D, HIS357E, HIS367E, HIS448D, HIS460D, HIS460E, HIS463D, HIS463E, HIS482D, HIS507D, HIS507E, HIS536E, ILE331D, ILE423E, ILE447D, ILE503E, ILE513E, ILE524D, ILE559D, LEU302D, LEU337D, LEU349D, LEU369E, LEU376E, LEU442D, LEU455D, LEU466E, LEU476D, LEU492E, LEU533E, LYS310E, LYS324E, LYS330D, LYS356D, LYS356E, LYS359D, LYS359E, LYS425E, LYS426E, LYS439D, LYS461D, LYS461E, LYS506D, LYS506E, LYS508D, LYS508E, MET316D, MET316E, MET364E, MET441D, PHE311E, PHE313E, PHE348D, PHE457D, PHE464D, PHE464E, PHE557D, PRO424E, PRO434D, PRO435D, PRO500E, SER305D, SER329D, SER353D, SER353E, SER440D, SER445D, SER453D, SER456D, SER462D, SER462E, SER468D, SER502E, SER522D, SER537E, SER552D, THR301D, THR315E, THR351D, THR351E, THR363E, THR373E, THR437D, THR472D, THR481D, THR490E, THR521D, THR549D, TRP319E, TRP465D, TRP465E, TYR321E, TYR333D, TYR335D, TYR368E, TYR487E, TYR491E, TYR499E, TYR534E, VAL317E, VAL358D, VAL365E, VAL454D, VAL477D, VAL501E, VAL511E
• D-K: ARG346D, ARG486K, ARG531K, GLY340D, SER341D
• D-L: ARG531L, GLU304D, SER305D
• E-F: ALA320F, ALA332E, ALA336E, ALA350E, ALA355E, ALA362E, ALA362F, ALA371F, ALA375F, ALA458E, ALA467E, ALA475E, ALA480E, ALA483E, ALA495F, ALA509F, ALA510F, ARG366E, ARG366F, ARG370F, ARG486F, ARG493F, ARG505E, ARG505F, ARG538F, ASN303E, ASN344F, ASN352E, ASN436E, ASN444E, ASN459E, ASN494F, ASN523E, ASN558E, ASP312F, ASP322F, ASP360F, ASP478E, ASP479E, ASP489F, ASP497F, ASP504F, ASP550E, CYS361F, CYS443E, CYS484E, CYS548E, GLN318F, GLN354E, GLN374F, GLN512F, GLU304E, GLU327E, GLU328E, GLU334E, GLU372F, GLU551E, GLY314F, GLY433E, GLY438E, GLY452E, GLY498F, HIS357E, HIS357F, HIS367F, HIS448E, HIS460E, HIS460F, HIS463E, HIS463F, HIS482E, HIS507E, HIS507F, ILE331E, ILE423F, ILE447E, ILE503F, ILE513F, ILE559E, LEU302E, LEU337E, LEU349E, LEU369F, LEU376F, LEU442E, LEU455E, LEU466F, LEU476E, LEU492F, LEU533F, LYS310F, LYS324F, LYS330E, LYS356E, LYS356F, LYS359E, LYS359F, LYS425F, LYS426F, LYS439E, LYS461E, LYS461F, LYS506E, LYS506F, LYS508E, LYS508F, MET316E, MET316F, MET364F, MET441E, PHE311F, PHE313F, PHE348E, PHE348F, PHE457E, PHE464E, PHE464F, PHE557E, PRO424F, PRO434E, PRO435E, PRO500F, SER305E, SER329E, SER353E, SER353F, SER440E, SER445E, SER453E, SER456E, SER462E, SER468E, SER502F, SER522E, SER537F, THR301E, THR315F, THR351E, THR351F, THR363F, THR373F, THR437E, THR472E, THR481E, THR490F, THR521E, THR549E, TRP319F, TRP465E, TRP465F, TYR321F, TYR333E, TYR335E, TYR368F, TYR487F, TYR491F, TYR499F, TYR534F, VAL317F, VAL358E, VAL365F, VAL454E, VAL501F, VAL511F
• E-G: ALA350E, ASP530G
• E-L: ALA528L, ARG346E, ARG531L, ASN344E, ASN523L, ASP342E, ASP525L, GLU529L, HIS482L, ILE524L, LYS310E, SER341E, SER343E, THR315E, TYR532L
• F-G: ALA528G, ARG531G, ASP312F, ASP525G, ASP530G, GLN527G, GLU529G, HIS482G, LYS310F, PHE311F
• G-H: ALA320H, ALA326G, ALA332G, ALA336G, ALA350G, ALA355G, ALA362G, ALA362H, ALA371H, ALA375H, ALA458G, ALA467G, ALA470H, ALA474G, ALA475G, ALA480G, ALA483G, ALA495H, ALA509H, ALA510H, ALA515H, ARG366G, ARG366H, ARG370H, ARG493H, ARG505H, ARG538H, ASN303G, ASN344H, ASN352G, ASN436G, ASN444G, ASN459G, ASN494H, ASN523G, ASN558G, ASP312H, ASP322H, ASP360H, ASP471H, ASP478G, ASP479G, ASP489H, ASP497H, ASP504H, ASP550G, CYS361H, CYS443G, CYS484G, GLN318H, GLN354G, GLN374H, GLN512H, GLN555G, GLU304G, GLU327G, GLU328G, GLU334G, GLU372H, GLY314H, GLY433G, GLY438G, GLY451G, GLY452G, GLY498H, HIS357G, HIS357H, HIS367H, HIS448G, HIS460G, HIS460H, HIS463H, HIS482G, HIS507G, HIS507H, HIS536H, ILE331G, ILE423H, ILE447G, ILE503H, ILE513H, ILE524G, LEU302G, LEU337G, LEU349G, LEU369H, LEU376H, LEU418H, LEU442G, LEU455G, LEU466H, LEU476G, LEU492H, LEU533H, LEU535H, LYS310H, LYS324H, LYS330G, LYS356G, LYS356H, LYS359G, LYS359H, LYS417H, LYS421H, LYS425H, LYS426H, LYS439G, LYS461G, LYS461H, LYS506G, LYS506H, LYS508G, LYS508H, LYS514H, MET316G, MET316H, MET364H, MET441G, PHE311H, PHE313H, PHE348G, PHE348H, PHE457G, PHE464G, PHE464H, PHE557G, PRO424H, PRO434G, PRO435G, PRO500H, PRO556G, SER305G, SER329G, SER353G, SER353H, SER440G, SER445G, SER453G, SER456G, SER462G, SER462H, SER468G, SER502H, SER522G, SER537H, THR301G, THR315H, THR351G, THR351H, THR363G, THR363H, THR373H, THR437G, THR472G, THR481G, THR490H, THR521G, THR549G, TRP319H, TRP465G, TRP465H, TYR321H, TYR333G, TYR335G, TYR368H, TYR487H, TYR491H, TYR499H, TYR534H, VAL317H, VAL358G, VAL365H, VAL454G, VAL477G, VAL501H, VAL511H, VAL539H
• G-L: ALA320G, ALA326L, ALA332L, ALA336L, ALA350L, ALA355L, ALA362G, ALA362L, ALA371G, ALA375G, ALA458L, ALA470G, ALA480L, ALA483G, ALA509G, ALA510G, ARG366G, ARG366L, ARG370G, ARG370L, ARG385L, ARG486G, ARG493G, ARG505G, ARG538G, ASN303L, ASN344G, ASN352L, ASN436L, ASN444L, ASN459L, ASN494G, ASN523L, ASN558L, ASP312G, ASP322G, ASP360G, ASP471G, ASP478L, ASP479L, ASP489G, ASP497G, ASP504G, ASP561L, CYS361G, CYS443L, GLN318G, GLN354L, GLN374G, GLN512G, GLU304L, GLU327L, GLU328L, GLU334L, GLU372G, GLY314G, GLY438L, GLY451L, GLY452L, GLY498G, HIS357G, HIS357L, HIS367G, HIS448L, HIS460G, HIS463G, HIS463L, HIS507G, HIS507L, ILE331L, ILE447L, ILE513G, ILE559L, LEU302L, LEU337L, LEU349L, LEU369G, LEU376G, LEU442L, LEU446L, LEU455L, LEU476L, LEU492G, LEU533G, LYS310G, LYS324G, LYS330L, LYS356G, LYS356L, LYS359G, LYS359L, LYS425G, LYS439L, LYS461G, LYS461L, LYS506L, LYS508G, LYS508L, LYS514G, MET316G, MET364G, MET441L, PHE311G, PHE313G, PHE348L, PHE449L, PHE457G, PHE457L, PHE464G, PHE464L, PHE488G, PRO424G, PRO435L, PRO500G, PRO556L, SER305L, SER329L, SER353G, SER353L, SER440L, SER445L, SER453L, SER456L, SER462G, SER462L, SER468L, SER502G, SER522L, SER537G, THR301L, THR315G, THR351G, THR351L, THR363G, THR363L, THR373G, THR472L, THR481L, THR490G, THR521L, THR560L, TRP319G, TRP465L, TRP564L, TYR321G, TYR333L, TYR335L, TYR368G, TYR487G, TYR491G, TYR499G, TYR534G, VAL317G, VAL358L, VAL365G, VAL454L, VAL501G, VAL511G
• H-I: ALA320I, ALA326H, ALA332H, ALA336H, ALA339H, ALA350H, ALA355H, ALA362H, ALA371I, ALA375I, ALA458H, ALA467H, ALA470I, ALA475H, ALA480H, ALA483H, ALA495I, ALA509I, ALA510I, ARG366H, ARG366I, ARG370I, ARG486H, ARG486I, ARG493I, ARG505H, ARG505I, ARG538I, ASN303H, ASN344I, ASN352H, ASN436H, ASN444H, ASN459H, ASN494I, ASN523H, ASN558H, ASP312I, ASP322I, ASP360I, ASP471I, ASP478H, ASP479H, ASP489I, ASP497I, ASP504I, CYS361I, CYS443H, CYS484H, GLN318I, GLN354H, GLN374I, GLN512I, GLU304H, GLU327H, GLU328H, GLU334H, GLU372I, GLY314I, GLY433H, GLY438H, GLY451H, GLY452H, GLY498I, HIS357H, HIS357I, HIS367I, HIS448H, HIS460H, HIS460I, HIS463H, HIS463I, HIS482H, HIS507H, HIS507I, HIS536I, ILE331H, ILE423I, ILE447H, ILE503I, ILE513I, ILE524H, LEU302H, LEU337H, LEU349H, LEU369I, LEU376I, LEU442H, LEU455H, LEU466I, LEU476H, LEU492I, LEU533I, LEU535I, LYS310I, LYS324I, LYS330H, LYS356H, LYS356I, LYS359H, LYS359I, LYS425I, LYS426I, LYS439H, LYS461H, LYS461I, LYS506H, LYS506I, LYS508H, LYS508I, LYS514I, MET316H, MET316I, MET364I, MET441H, PHE311I, PHE313I, PHE348H, PHE457H, PHE464H, PHE464I, PHE488I, PRO424I, PRO434H, PRO435H, PRO500I, SER305H, SER329H, SER353H, SER353I, SER440H, SER445H, SER453H, SER456H, SER462H, SER462I, SER468H, SER502I, SER522H, SER537I, THR301H, THR315I, THR351H, THR351I, THR363I, THR373I, THR472H, THR481H, THR490I, THR521H, THR549H, TRP319I, TRP465H, TRP465I, TYR321I, TYR333H, TYR335H, TYR368I, TYR487H, TYR487I, TYR491I, TYR499I, TYR534I, VAL317I, VAL358H, VAL365I, VAL454H, VAL477H, VAL501I, VAL511I
• H-J: HIS507H, HIS507J
• H-L: HIS463H, HIS507L, LYS461L, LYS506L, TYR491H
• I-J: ALA320J, ALA326I, ALA332I, ALA336I, ALA350I, ALA355I, ALA362I, ALA371J, ALA375J, ALA458I, ALA467I, ALA470J, ALA475I, ALA480I, ALA483I, ALA495J, ALA509J, ALA510J, ARG366I, ARG366J, ARG370J, ARG486I, ARG486J, ARG493J, ARG505J, ARG538J, ASN303I, ASN344J, ASN352I, ASN436I, ASN444I, ASN459I, ASN494J, ASN523I, ASN558I, ASP312J, ASP322J, ASP360J, ASP471J, ASP478I, ASP479I, ASP489J, ASP497J, ASP504J, CYS361J, CYS484I, GLN318J, GLN354I, GLN374J, GLN512J, GLU304I, GLU327I, GLU328I, GLU334I, GLU372J, GLY314J, GLY433I, GLY438I, GLY451I, GLY452I, HIS357I, HIS357J, HIS367J, HIS448I, HIS460I, HIS460J, HIS463I, HIS463J, HIS482I, HIS507I, HIS507J, HIS536J, ILE331I, ILE423J, ILE447I, ILE503J, ILE513J, ILE524I, LEU302I, LEU337I, LEU349I, LEU369J, LEU376J, LEU418J, LEU442I, LEU455I, LEU466I, LEU466J, LEU476I, LEU492J, LEU533J, LEU535J, LYS310J, LYS324J, LYS330I, LYS356I, LYS356J, LYS359I, LYS359J, LYS425J, LYS426J, LYS439I, LYS461I, LYS461J, LYS506I, LYS506J, LYS508J, LYS514J, MET316I, MET316J, MET364J, MET441I, PHE311J, PHE313J, PHE348I, PHE457I, PHE464I, PHE464J, PHE488J, PRO424J, PRO434I, PRO435I, PRO500J, PRO556I, SER305I, SER329I, SER353I, SER440I, SER445I, SER453I, SER456I, SER462I, SER462J, SER468I, SER502J, SER522I, SER537J, THR301I, THR315J, THR351I, THR351J, THR363J, THR373J, THR472I, THR481I, THR490J, THR521I, THR549I, TRP319J, TRP465I, TRP465J, TYR321J, TYR333I, TYR335I, TYR368J, TYR487I, TYR487J, TYR491J, TYR499J, TYR534J, VAL317J, VAL358I, VAL365J, VAL454I, VAL477I, VAL501J, VAL511J
• J-K: ALA320K, ALA332J, ALA336J, ALA350J, ALA355J, ALA362K, ALA371K, ALA375K, ALA458J, ALA467J, ALA470K, ALA475J, ALA480J, ALA483J, ALA509K, ALA510K, ARG366J, ARG366K, ARG370K, ARG486K, ARG493K, ARG505J, ARG505K, ARG538K, ASN303J, ASN344K, ASN352J, ASN436J, ASN444J, ASN459J, ASN494K, ASN523J, ASN558J, ASP312K, ASP322K, ASP360K, ASP471K, ASP478J, ASP479J, ASP489K, ASP497K, ASP504K, CYS361K, CYS443J, CYS484J, CYS548J, GLN318K, GLN354J, GLN374K, GLN512K, GLN555J, GLU304J, GLU327J, GLU328J, GLU334J, GLU372K, GLU551J, GLU554J, GLY314K, GLY433J, GLY438J, GLY451J, GLY452J, GLY498K, GLY553J, HIS357J, HIS357K, HIS367K, HIS448J, HIS460J, HIS460K, HIS463J, HIS463K, HIS482J, HIS507J, HIS507K, HIS536K, ILE331J, ILE447J, ILE503K, ILE513K, ILE524J, ILE559J, LEU302J, LEU337J, LEU349J, LEU369K, LEU376K, LEU442J, LEU455J, LEU466K, LEU476J, LEU492K, LEU533K, LYS310K, LYS324K, LYS330J, LYS356J, LYS356K, LYS359J, LYS359K, LYS425K, LYS426K, LYS439J, LYS461J, LYS461K, LYS506J, LYS506K, LYS508J, LYS508K, MET316J, MET316K, MET364K, MET441J, PHE311K, PHE313K, PHE348J, PHE457J, PHE464J, PHE464K, PHE557J, PRO424K, PRO434J, PRO435J, PRO500K, SER305J, SER329J, SER353J, SER353K, SER440J, SER445J, SER453J, SER456J, SER462J, SER462K, SER468J, SER502K, SER522J, SER537K, SER552J, THR301J, THR315K, THR351J, THR351K, THR363K, THR373K, THR437J, THR472J, THR481J, THR490K, THR521J, THR549J, TRP319K, TRP465J, TRP465K, TYR321K, TYR333J, TYR335J, TYR368K, TYR487K, TYR491K, TYR499K, TYR534K, VAL317K, VAL358J, VAL365K, VAL454J, VAL477J, VAL501K, VAL511K
• K-L: ALA320L, ALA332K, ALA336K, ALA350K, ALA355K, ALA362L, ALA371L, ALA375L, ALA458K, ALA467K, ALA475K, ALA480K, ALA483K, ALA495L, ALA509L, ALA510L, ARG366K, ARG366L, ARG370L, ARG486L, ARG493L, ARG505K, ARG505L, ARG538L, ASN303K, ASN344L, ASN352K, ASN436K, ASN444K, ASN459K, ASN494L, ASN523K, ASN558K, ASP312L, ASP322L, ASP360L, ASP471L, ASP478K, ASP479K, ASP489L, ASP497L, ASP504L, CYS361L, CYS443K, CYS484K, GLN318L, GLN354K, GLN374L, GLN512L, GLU304K, GLU327K, GLU328K, GLU334K, GLU372L, GLY314L, GLY433K, GLY438K, GLY452K, GLY498L, HIS357K, HIS357L, HIS367L, HIS448K, HIS460K, HIS460L, HIS463K, HIS463L, HIS482K, HIS507K, HIS507L, ILE331K, ILE447K, ILE503L, ILE513L, ILE559K, LEU302K, LEU337K, LEU349K, LEU369L, LEU376L, LEU442K, LEU455K, LEU466L, LEU476K, LEU492L, LEU533L, LYS310L, LYS324L, LYS330K, LYS356K, LYS356L, LYS359K, LYS359L, LYS425L, LYS439K, LYS461K, LYS461L, LYS506K, LYS506L, LYS508K, LYS508L, LYS514L, MET316K, MET316L, MET364L, MET441K, PHE311L, PHE313L, PHE348K, PHE457K, PHE457L, PHE464K, PHE464L, PHE557K, PRO424L, PRO434K, PRO435K, PRO500L, SER305K, SER329K, SER353K, SER353L, SER440K, SER445K, SER453K, SER456K, SER462K, SER468K, SER502L, SER522K, SER537L, THR301K, THR315L, THR351K, THR351L, THR363L, THR373L, THR437K, THR472K, THR481K, THR490L, THR521K, THR549K, TRP319L, TRP465K, TRP465L, TYR321L, TYR333K, TYR335K, TYR368L, TYR487L, TYR491L, TYR499L, TYR534L, VAL317L, VAL358K, VAL365L, VAL454K, VAL501L, VAL511L