2V4M

the isomerase domain of human glutamine-fructose-6- phosphate transaminase 1 (gfpt1) in complex with fructose 6-phosphate

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 37
  • Norm. En. per Res.: -5.4792
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-95.5796	-143.5427	-524.14	-763.2623	207	43	6	21455	22	108	80
A-C	-36.7882	8.0557	-109.886	-138.6185	52	4	0	4719	3	41	50
A-D	-59.7961	-30.6031	-112.33	-202.7292	37	10	1	3358	3	25	30
B-C	-44.3365	6.5731	-100.166	-137.9294	33	4	1	2892	0	24	28
B-D	-48.7441	-12.3918	-112.52	-173.6559	55	8	0	4630	3	37	45
C-D	-86.6914	-169.4872	-545.686	-801.8646	213	38	6	22014	23	107	85

Interface residues

• A-B: ALA391A, ALA391B, ALA419A, ALA419B, ALA445A, ALA445B, ALA491A, ALA491B, ALA574A, ALA574B, ALA590A, ALA590B, ALA599A, ALA599B, ARG385A, ARG385B, ARG386A, ARG386B, ARG403A, ARG403B, ARG425A, ARG425B, ARG563A, ARG563B, ARG630A, ARG630B, ARG682A, ARG682B, ASN426A, ASN426B, ASP421A, ASP421B, ASP424A, ASP424B, ASP432A, ASP432B, ASP433A, ASP433B, ASP446A, ASP446B, ASP602A, ASP602B, ASP614A, ASP614B, CYS392A, CYS392B, CYS620A, GLN404A, GLN404B, GLN555B, GLU407A, GLU407B, GLU408A, GLU408B, GLU411A, GLU411B, GLU417A, GLU417B, GLU579A, GLU579B, GLU586A, GLU586B, GLU592A, GLU592B, GLY393A, GLY393B, GLY562B, GLY564A, GLY564B, GLY587A, GLY587B, GLY591A, GLY591B, GLY596A, GLY596B, HIS397A, HIS397B, HIS554B, HIS566A, HIS566B, HIS584A, HIS584B, HIS595A, HIS595B, HIS615A, HIS615B, ILE388A, ILE388B, ILE560A, ILE560B, ILE577A, ILE577B, ILE580A, ILE580B, ILE588A, ILE588B, LEU387A, LEU387B, LEU406A, LEU406B, LEU409B, LEU412A, LEU412B, LEU418A, LEU418B, LEU423A, LEU423B, LEU559A, LEU559B, LEU571A, LEU571B, LEU575A, LEU575B, LEU589A, LEU589B, LEU593A, LEU593B, LEU598A, LEU598B, LEU600A, LEU600B, LEU604A, LEU604B, LYS556A, LYS556B, LYS576A, LYS576B, LYS578A, LYS578B, LYS594A, LYS594B, LYS619A, LYS619B, MET415A, MET415B, MET449A, MET449B, MET561A, MET583A, MET583B, MET605A, MET605B, PHE422A, PHE422B, PHE430A, PHE430B, PRO413A, PRO413B, PRO428A, PRO428B, PRO597A, PRO597B, PRO606A, SER395A, SER395B, SER420A, SER420B, SER439B, SER441A, SER492A, SER492B, SER557A, SER557B, SER585A, SER585B, THR394A, THR394B, THR402A, THR402B, THR410A, THR410B, THR427A, THR427B, THR444A, THR444B, THR447A, THR447B, THR581A, THR581B, THR616A, THR616B, TYR396A, TYR396B, TYR453A, TYR565A, TYR565B, TYR567A, TYR567B, TYR582A, TYR582B, TYR684B, VAL400A, VAL400B, VAL405A, VAL405B, VAL414A, VAL414B, VAL416A, VAL416B, VAL429A, VAL429B, VAL490A, VAL490B, VAL558A, VAL558B, VAL601A, VAL601B
• A-C: ALA459A, ALA459C, ARG383A, ARG383C, ARG385A, ARG385C, ARG431A, ARG431C, ARG457A, ARG457C, ASP432A, ASP432C, ASP433A, ASP433C, ASP477A, ASP477C, CYS384A, CYS384C, CYS435A, CYS435C, CYS454A, CYS454C, GLN382A, GLN382C, GLU380A, GLU380C, GLU456A, GLU456C, GLY458A, GLY458C, HIS377A, HIS377C, ILE381A, ILE381C, LEU460A, LEU460C, LYS379A, LYS379C, LYS455A, LYS455C, PHE430A, PHE430C, PRO428A, PRO428C, THR461A, THR461C, TYR453A, TYR453C, VAL429A, VAL429C, VAL434A, VAL434C
• A-D: ARG383A, ARG383D, ARG385A, ARG385D, ARG514A, ARG514D, ARG521A, ARG521D, ASP432A, ASP432D, ASP512A, ASP512D, ASP513A, ASP513D, CYS384A, CYS384D, CYS511A, CYS511D, GLN382A, GLN382D, GLN518A, GLN518D, GLU411A, GLU411D, ILE515A, ILE515D, LEU412A, LEU412D, LYS379A, LYS379D, LYS522D, MET510D, MET517A, MET517D, PRO413A, SER516A, SER516D
• B-C: ARG383B, ARG383C, ARG385B, ARG385C, ARG514B, ARG514C, ARG521B, ARG521C, ASP432B, ASP432C, ASP512B, ASP512C, ASP513B, ASP513C, CYS384B, CYS384C, CYS511B, CYS511C, GLN382B, GLN382C, GLN518B, GLN518C, GLU411B, GLU411C, ILE515B, ILE515C, LEU412B, LEU412C, MET517B, MET517C, PRO413C, SER516B, SER516C
• B-D: ALA459B, ALA459D, ARG383B, ARG383D, ARG385B, ARG385D, ARG386B, ARG386D, ARG431B, ARG431D, ARG457B, ARG457D, ASP432B, ASP432D, ASP433B, ASP433D, ASP477B, ASP477D, CYS384B, CYS384D, CYS435B, CYS435D, CYS454B, CYS454D, GLN382B, GLN382D, GLU380B, GLU380D, GLU456B, GLU456D, GLY458B, GLY458D, HIS377B, HIS377D, ILE381B, ILE381D, LEU460B, LEU460D, LYS379B, LYS455B, LYS455D, PHE430B, PHE430D, PRO428B, PRO428D, THR427B, THR427D, THR461B, THR461D, TYR453B, TYR453D, VAL429B, VAL429D, VAL434B, VAL434D
• C-D: ALA391C, ALA391D, ALA419C, ALA419D, ALA445C, ALA445D, ALA491C, ALA491D, ALA568C, ALA568D, ALA574C, ALA574D, ALA590C, ALA590D, ALA599C, ALA599D, ARG385C, ARG385D, ARG386C, ARG386D, ARG403C, ARG403D, ARG425C, ARG425D, ARG563C, ARG563D, ARG630C, ARG630D, ARG682C, ARG682D, ARG690C, ASN426C, ASN426D, ASP421C, ASP421D, ASP424C, ASP424D, ASP432C, ASP432D, ASP433C, ASP433D, ASP446C, ASP446D, ASP602C, ASP602D, ASP614C, ASP614D, CYS392C, CYS392D, CYS620D, GLN404C, GLN404D, GLN555C, GLN631D, GLU407C, GLU407D, GLU408C, GLU408D, GLU411C, GLU411D, GLU417C, GLU417D, GLU579C, GLU579D, GLU586C, GLU586D, GLU592C, GLU592D, GLY393C, GLY393D, GLY562C, GLY562D, GLY564C, GLY564D, GLY587C, GLY587D, GLY591C, GLY591D, GLY596C, GLY596D, HIS397C, HIS397D, HIS554C, HIS566C, HIS566D, HIS584C, HIS584D, HIS595C, HIS595D, HIS615C, HIS615D, ILE388C, ILE388D, ILE560C, ILE560D, ILE577C, ILE577D, ILE580C, ILE580D, ILE588C, ILE588D, LEU387C, LEU387D, LEU406C, LEU406D, LEU412C, LEU412D, LEU418C, LEU418D, LEU423C, LEU423D, LEU559C, LEU559D, LEU571C, LEU571D, LEU575C, LEU575D, LEU589C, LEU589D, LEU593C, LEU593D, LEU598C, LEU598D, LEU600C, LEU600D, LEU604C, LEU604D, LYS556C, LYS556D, LYS576C, LYS576D, LYS578C, LYS578D, LYS594C, LYS594D, LYS603D, LYS619C, LYS619D, MET415C, MET415D, MET449C, MET449D, MET561C, MET561D, MET583C, MET583D, MET605C, MET605D, PHE422C, PHE422D, PHE430C, PHE430D, PRO413C, PRO413D, PRO428C, PRO428D, PRO597C, PRO597D, PRO606C, PRO606D, PRO689C, SER395C, SER395D, SER420C, SER420D, SER492C, SER492D, SER557C, SER557D, SER585C, SER585D, THR394C, THR394D, THR402C, THR402D, THR410C, THR410D, THR427C, THR427D, THR444C, THR444D, THR447C, THR447D, THR581C, THR581D, THR616C, THR616D, TYR396C, TYR396D, TYR453D, TYR565C, TYR565D, TYR567C, TYR567D, TYR582C, TYR582D, TYR684D, VAL400C, VAL400D, VAL405C, VAL405D, VAL414C, VAL414D, VAL416C, VAL416D, VAL429C, VAL429D, VAL490C, VAL490D, VAL558C, VAL558D, VAL601C, VAL601D