2V2H

the a178l mutation in the c-terminal hinge of the flexible loop-6 of triosephosphate isomerase (tim) induces a more closed conformation of this hinge region in dimeric and monomeric tim

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 54
  • Norm. En. per Res.: -1.0265
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-19.4145	-6.5806	-29.4333	-55.4284	54	4	0	1897	0	13	18
A-C	-2.1901	-9.6208	-30.5293	-42.3402	51	1	0	1769	1	13	17
B-C	0.0	1.6503	-25.6542	-24.0039	47	0	0	1702	0	11	18

Interface residues

• A-B: ALA200A, ALA203A, ALA49B, ARG220A, ARG226A, ARG54B, ASN29B, ASN34A, ASN34B, ASN89B, ASP201A, ASP36A, ASP36B, ASP85B, CYS39B, GLN184A, GLN224A, GLN225A, GLN250A, GLN38B, GLN5A, GLU205A, GLU53B, GLY120B, GLY199A, GLY204A, GLY87B, HIS35A, HIS57B, ILE33B, ILE62B, LEU55B, LYS161B, LYS3A, LYS52B, LYS59B, LYS84B, MET50B, PHE60B, PRO4A, PRO58B, PRO6A, SER119B, SER195A, SER2A, SER30B, SER32B, SER56B, THR249A, THR51B, TRP90B, TYR223A, VAL40B, VAL61B
• A-C: ALA200C, ALA203C, ALA49A, ARG220C, ARG226C, ARG54A, ASN29A, ASN34A, ASN34C, ASN89A, ASP201C, ASP36A, ASP36C, ASP85A, CYS39A, GLN184C, GLN224C, GLN225C, GLN250C, GLN38A, GLU205C, GLU53A, GLY120A, GLY199C, GLY204C, GLY87A, HIS35C, HIS57A, ILE33A, ILE62A, LEU55A, LYS161A, LYS3C, LYS52A, LYS59A, LYS84A, MET50A, PHE60A, PRO4C, PRO58A, PRO6C, SER119A, SER195C, SER2C, SER32A, SER56A, THR249C, THR51A, TRP90A, TYR223C, VAL61A
• B-C: ALA200B, ALA203B, ARG220B, ARG226B, ARG54C, ASN29C, ASN34B, ASN34C, ASN89C, ASP201B, ASP36B, ASP36C, ASP85C, CYS39C, GLN224B, GLN250B, GLN38C, GLU205B, GLU53C, GLY120C, GLY204B, GLY87C, HIS35B, HIS57C, ILE33C, ILE62C, LEU55C, LYS161C, LYS3B, LYS52C, LYS59C, LYS84C, PHE60C, PHE86C, PRO4B, PRO58C, PRO6B, SER119C, SER195B, SER2B, SER32C, SER56C, THR249B, THR51C, TRP90C, TYR223B, VAL61C