2UZ6

achbp-targeted a-conotoxin correlates distinct binding orientations with nachr subtype selectivity.

• Total interactions analyzed: 210
• Total true interactions: 34
• Strongest Interaction:
  • Chains: H-R
  • Int. Res.: 47
  • Norm. En. per Res.: -4.3238
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-27.4001	1.3373	-247.047	-273.1097	121	15	2	10844	1	24	20
A-E	-21.7812	0.5393	-256.296	-277.538	119	9	2	10715	3	21	19
A-I	-18.8396	0.7079	-91.5511	-109.6828	70	6	0	4413	2	40	29
A-K	-12.9072	-21.4942	-147.117	-181.5184	50	10	1	5270	2	4	3
A-O	0.0	-11.3655	-72.8274	-84.1929	50	10	3	4093	1	4	5
A-R	0.0	0.0	-0.0174	-0.0174	2	0	0	6	0	3	3
B-C	-45.7856	0.112	-270.128	-315.8016	120	10	1	11113	2	20	19
B-K	-3.3645	-6.5508	-82.6026	-92.5179	51	10	3	4166	0	5	3
B-L	-8.1246	-21.3069	-155.552	-184.9836	48	7	1	5264	2	4	3
C-D	-38.6783	3.7031	-269.17	-304.1452	119	12	2	11175	1	23	20
C-L	-2.1359	-2.5476	-87.1276	-91.8111	51	4	3	4189	0	4	4
C-M	0.0	-30.2552	-154.095	-184.3502	46	5	1	5219	2	4	3
D-E	-17.0129	10.0733	-250.655	-257.5945	119	6	2	10632	1	23	19
D-M	-5.9421	5.5223	-78.4417	-78.8614	47	9	3	3744	0	4	4
D-N	-7.8211	-25.9788	-153.007	-186.8069	46	7	1	5112	2	4	3
E-N	-2.9207	5.194	-89.1865	-86.9132	50	3	3	3999	0	4	4
E-O	-2.7789	-28.9741	-150.735	-182.488	47	12	1	5192	2	4	3
F-G	-30.8546	7.4638	-245.685	-269.0759	116	7	2	10432	2	23	20
F-J	-20.0617	4.2313	-269.244	-285.0744	117	9	2	10885	2	23	20
F-P	-9.524	-26.2225	-140.878	-176.6245	48	6	1	5174	2	4	3
F-T	-3.5578	2.8106	-66.7261	-67.4732	49	10	3	3773	0	4	4
G-H	-27.6944	5.4581	-247.725	-269.9614	123	8	2	10729	1	22	19
G-P	0.0	-2.5709	-77.4664	-80.0373	49	1	3	3819	0	4	4
G-Q	-3.671	-23.8844	-153.145	-180.7004	49	10	1	5349	2	4	3
H-I	-19.5841	8.1006	-248.719	-260.2025	121	10	2	10682	1	23	20
H-Q	-2.2925	-7.9535	-77.492	-87.738	49	2	3	3820	0	4	4
H-R	-21.5556	-27.1415	-154.521	-203.2181	47	7	1	5297	1	4	3
I-J	-37.1261	5.0421	-255.862	-287.946	122	15	2	10950	0	20	19
I-O	0.0	0.0	-0.0227	-0.0227	4	0	0	11	0	3	2
I-R	-2.1277	-20.3172	-84.7161	-107.161	50	5	3	3951	2	5	5
I-S	-10.198	-24.9244	-146.972	-182.0944	46	10	1	5306	2	4	3
J-S	-4.5884	-1.5212	-83.6954	-89.805	50	3	3	4009	0	4	3
J-T	-14.222	-21.2204	-154.608	-190.0505	47	6	1	5111	2	4	3
O-R	0.0	16.0918	-0.9726	15.1191	5	0	0	56	0	0	1

Interface residues

• A-B: ALA105B, ALA118B, ALA139A, ALA168B, ALA2B, ALA80B, ALA90A, ARG120B, ARG205B, ARG6B, ARG77B, ARG95A, ARG95B, ASN3B, ASN46A, ASN61A, ASN72B, ASP126A, ASP24A, ASP25A, ASP37B, ASP42A, ASP49B, ASP75B, ASP87A, CYS125A, CYS138A, GLN103B, GLN119B, GLN1B, GLN36B, GLN98A, GLN98B, GLU151A, GLU191A, GLU47A, GLU54B, GLY143A, GLY20A, GLY71B, ILE104B, ILE116B, ILE152A, ILE38B, ILE73B, ILE88A, LEU100B, LEU121A, LEU35B, LEU4B, LEU50B, LEU60A, LEU7B, LYS141A, LYS171B, LYS23A, LYS40B, LYS8B, MET114B, MET124A, MET17A, MET5B, PHE115B, PHE123A, PHE150A, PHE76B, PRO102B, PRO117B, PRO127A, PRO16A, PRO19A, PRO21A, PRO26A, PRO86A, PRO96A, SER101B, SER122A, SER122B, SER144A, SER148A, SER15A, SER165B, SER169B, SER170B, SER43A, SER44A, SER62A, SER79B, SER92A, SER93A, SER9B, THR128A, THR137A, THR22A, THR45A, THR74B, THR78B, THR85A, THR89A, THR94A, TRP145A, TRP84A, TYR147A, TYR166B, TYR167B, TYR172B, TYR18A, TYR193A, TYR52B, TYR53B, TYR91A, VAL106B, VAL136A, VAL146A, VAL39B, VAL41B, VAL48A, VAL51B, VAL97A, VAL97B, VAL99B
• A-E: ALA105A, ALA118A, ALA139E, ALA168A, ALA2A, ALA80A, ALA90E, ARG120A, ARG205A, ARG6A, ARG77A, ARG95E, ASN3A, ASN46E, ASN61E, ASN72A, ASP126E, ASP24E, ASP25E, ASP37A, ASP42E, ASP49A, ASP75A, ASP87E, CYS125E, CYS138E, GLN103A, GLN119A, GLN1A, GLN36A, GLN98A, GLN98E, GLU151E, GLU191E, GLU47E, GLU54A, GLY143E, GLY20E, GLY71A, ILE104A, ILE116A, ILE152E, ILE38A, ILE73A, ILE88E, LEU100A, LEU121E, LEU35A, LEU4A, LEU50A, LEU60E, LYS141E, LYS171A, LYS23E, LYS40A, LYS40E, LYS8A, MET114A, MET124E, MET17E, MET5A, PHE115A, PHE123E, PHE76A, PRO102A, PRO117A, PRO127E, PRO16E, PRO19E, PRO21E, PRO86E, PRO96E, SER101A, SER122A, SER122E, SER144E, SER148E, SER15E, SER165A, SER169A, SER170A, SER43E, SER44E, SER62E, SER79A, SER92E, SER93E, SER9A, THR128E, THR137E, THR22E, THR34A, THR45E, THR78A, THR85E, THR89E, THR94E, TRP145E, TRP84E, TYR147E, TYR166A, TYR167A, TYR172A, TYR18E, TYR193E, TYR52A, TYR53A, TYR91E, VAL106A, VAL136E, VAL140E, VAL146E, VAL39A, VAL41A, VAL48E, VAL51A, VAL97A, VAL97E, VAL99A
• A-I: ARG181A, ARG181I, ASN61A, ASN61I, ASP110A, ASP110I, ASP153A, ASP153I, ASP157A, ASP157I, ASP159A, ASP159I, ASP24A, ASP24I, ASP25A, ASP25I, CYS189A, CYS189I, GLN160A, GLN160I, GLN182A, GLN182I, GLN184A, GLN184I, GLU151A, GLU151I, GLU191A, GLU191I, GLY149A, GLY149I, HIS185A, HIS185I, ILE194A, ILE194I, LEU27A, LEU27I, LYS155A, LYS155I, LYS23A, LYS23I, LYS59A, LYS59I, MET64A, MET64I, PHE150A, PHE150I, PRO190A, PRO190I, PRO192A, PRO192I, PRO26A, PRO26I, THR156A, THR156I, THR158A, THR158I, THR180A, THR180I, THR22A, THR22I, THR28A, THR28I, THR30I, TYR186A, TYR193A, TYR193I, VAL183A, VAL183I, VAL29A, VAL29I
• A-K: ALA90A, ARG5K, ASN11K, ASN12K, ASN197A, ASP195A, ASP87A, CYS16K, CYS188A, CYS189A, CYS2K, CYS3K, CYS8K, GLN182A, GLN184A, GLU151A, GLU191A, GLY143A, GLY149A, GLY1K, HIS185A, ILE152A, ILE194A, ILE9K, LEU10K, LEU154A, LEU15K, LYS141A, LYS23A, PHE142A, PHE150A, PRO13K, PRO190A, PRO192A, PRO6K, PRO7K, SER144A, SER148A, SER187A, SER4K, SER92A, THR89A, TRP145A, TYR147A, TYR186A, TYR193A, TYR91A, VAL146A, VAL183A, VAL196A
• A-O: ALA105A, ALA118A, ARG57A, ARG5O, ARG77A, ASN11O, ASN12O, ASP14O, ASP157A, ASP162A, ASP75A, CYS16O, CYS2O, CYS3O, CYS8O, GLN179A, GLN36A, GLN55A, GLN56A, GLU54A, GLY1O, ILE104A, ILE116A, ILE9O, LEU10O, LEU15O, LEU163A, MET114A, PHE115A, PHE76A, PRO102A, PRO117A, PRO13O, PRO6O, PRO7O, SER101A, SER112A, SER164A, SER165A, SER4O, THR108A, THR158A, THR30A, THR34A, THR78A, TYR166A, TYR53A, VAL106A, VAL107A, VAL113A
• A-R: ARG57A, ASP14R
• B-C: ALA105C, ALA118C, ALA139B, ALA168C, ALA2C, ALA90B, ARG120C, ARG205C, ARG6C, ARG77C, ARG95B, ARG95C, ASN13C, ASN3C, ASN46B, ASN61B, ASN72C, ASP126B, ASP24B, ASP25B, ASP37C, ASP42B, ASP49C, ASP75C, ASP87B, CYS125B, CYS138B, GLN103C, GLN119C, GLN1C, GLN36C, GLN98B, GLN98C, GLU151B, GLU191B, GLU47B, GLU54C, GLY143B, GLY20B, GLY71C, ILE104C, ILE116C, ILE152B, ILE38C, ILE73C, ILE88B, LEU100C, LEU121B, LEU35C, LEU4C, LEU50C, LEU60B, LEU7C, LYS141B, LYS171C, LYS23B, LYS40C, LYS8C, MET124B, MET17B, MET5C, PHE115C, PHE123B, PHE150B, PHE76C, PRO102C, PRO117C, PRO127B, PRO16B, PRO19B, PRO21B, PRO86B, PRO96B, SER101C, SER122B, SER122C, SER144B, SER148B, SER15B, SER165C, SER169C, SER170C, SER43B, SER44B, SER62B, SER79C, SER92B, SER93B, SER9C, THR128B, THR137B, THR22B, THR45B, THR74C, THR78C, THR85B, THR89B, THR94B, TRP145B, TRP84B, TYR147B, TYR166C, TYR167C, TYR172C, TYR18B, TYR193B, TYR52C, TYR53C, TYR91B, VAL106C, VAL136B, VAL140B, VAL146B, VAL39C, VAL41C, VAL48B, VAL51C, VAL97B, VAL97C, VAL99C
• B-K: ALA105B, ALA118B, ARG57B, ARG5K, ARG77B, ASN11K, ASN12K, ASP14K, ASP157B, ASP162B, ASP75B, CYS16K, CYS2K, CYS3K, CYS8K, GLN36B, GLN55B, GLN56B, GLU54B, GLY1K, GLY32B, ILE104B, ILE116B, ILE9K, LEU10K, LEU15K, LEU163B, MET114B, PHE115B, PHE33B, PHE76B, PRO102B, PRO117B, PRO13K, PRO6K, PRO7K, SER101B, SER112B, SER164B, SER165B, SER4K, THR108B, THR158B, THR30B, THR34B, THR78B, TYR166B, TYR53B, VAL106B, VAL107B, VAL113B
• B-L: ALA90B, ARG5L, ASN11L, ASN12L, ASN197B, ASP195B, ASP87B, CYS16L, CYS188B, CYS189B, CYS2L, CYS3L, CYS8L, GLN182B, GLN184B, GLU151B, GLU191B, GLY143B, GLY149B, GLY1L, HIS185B, ILE194B, ILE9L, LEU10L, LEU154B, LEU15L, LYS141B, LYS23B, PHE142B, PHE150B, PRO190B, PRO192B, PRO6L, PRO7L, SER144B, SER148B, SER187B, SER4L, SER92B, THR89B, TRP145B, TYR147B, TYR186B, TYR193B, TYR91B, VAL146B, VAL183B, VAL196B
• C-D: ALA105D, ALA118D, ALA139C, ALA168D, ALA2D, ALA90C, ARG120D, ARG205D, ARG6D, ARG77D, ARG95C, ASN13D, ASN3D, ASN46C, ASN61C, ASN72D, ASP126C, ASP24C, ASP25C, ASP37D, ASP42C, ASP49D, ASP75D, ASP87C, CYS125C, CYS138C, GLN103D, GLN119D, GLN1D, GLN36D, GLN98D, GLU151C, GLU191C, GLU47C, GLU54D, GLY143C, GLY20C, GLY71D, ILE104D, ILE116D, ILE38D, ILE73D, ILE88C, LEU100D, LEU121C, LEU27C, LEU35D, LEU4D, LEU50D, LEU60C, LEU63C, LEU7D, LYS141C, LYS171D, LYS23C, LYS40D, LYS59C, LYS8D, MET114D, MET124C, MET17C, MET5D, PHE115D, PHE123C, PHE76D, PRO102D, PRO117D, PRO127C, PRO16C, PRO19C, PRO21C, PRO26C, PRO86C, PRO96C, SER101D, SER122C, SER122D, SER144C, SER148C, SER15C, SER165D, SER169D, SER170D, SER43C, SER44C, SER62C, SER79D, SER92C, SER93C, SER9D, THR128C, THR137C, THR22C, THR34D, THR45C, THR78D, THR85C, THR89C, THR94C, TRP145C, TRP84C, TYR147C, TYR166D, TYR167D, TYR172D, TYR18C, TYR193C, TYR52D, TYR53D, TYR91C, VAL106D, VAL136C, VAL146C, VAL39D, VAL41D, VAL51D, VAL97C, VAL97D, VAL99D
• C-L: ALA105C, ALA118C, ARG57C, ARG5L, ARG77C, ASN11L, ASN12L, ASP14L, ASP157C, ASP162C, ASP75C, CYS16L, CYS2L, CYS3L, CYS8L, GLN36C, GLN55C, GLN56C, GLU54C, GLY1L, GLY32C, ILE104C, ILE116C, ILE9L, LEU10L, LEU15L, LEU163C, MET114C, PHE115C, PHE33C, PHE76C, PRO102C, PRO117C, PRO13L, PRO6L, PRO7L, SER101C, SER112C, SER164C, SER165C, SER4L, THR108C, THR158C, THR30C, THR34C, THR78C, TYR166C, TYR53C, VAL106C, VAL107C, VAL113C
• C-M: ALA90C, ARG5M, ASN11M, ASN12M, ASN197C, ASP195C, ASP87C, CYS188C, CYS189C, CYS2M, CYS3M, CYS8M, GLN182C, GLN184C, GLU151C, GLU191C, GLY143C, GLY149C, GLY1M, ILE194C, ILE9M, LEU10M, LEU154C, LEU15M, LYS141C, LYS23C, PHE142C, PHE150C, PRO190C, PRO192C, PRO6M, PRO7M, SER144C, SER148C, SER187C, SER4M, SER92C, THR89C, TRP145C, TYR147C, TYR186C, TYR193C, TYR91C, VAL146C, VAL183C, VAL196C
• D-E: ALA105E, ALA118E, ALA139D, ALA168E, ALA2E, ALA90D, ARG120E, ARG205E, ARG6E, ARG77E, ARG95D, ASN13E, ASN3E, ASN46D, ASN61D, ASN72E, ASP126D, ASP24D, ASP25D, ASP37E, ASP42D, ASP49E, ASP75E, ASP87D, CYS125D, CYS138D, GLN103E, GLN119E, GLN1E, GLN36E, GLN98E, GLU151D, GLU191D, GLU47D, GLU54E, GLY143D, GLY20D, GLY71E, ILE104E, ILE116E, ILE152D, ILE38E, ILE73E, ILE88D, LEU100E, LEU121D, LEU27D, LEU35E, LEU4E, LEU50E, LEU60D, LEU7E, LYS141D, LYS171E, LYS23D, LYS40D, LYS40E, LYS8E, MET114E, MET124D, MET17D, MET5E, PHE115E, PHE123D, PHE76E, PRO102E, PRO117E, PRO127D, PRO16D, PRO19D, PRO21D, PRO26D, PRO86D, PRO96D, SER101E, SER122D, SER144D, SER148D, SER15D, SER165E, SER169E, SER170E, SER43D, SER44D, SER62D, SER79E, SER92D, SER93D, SER9E, THR128D, THR137D, THR22D, THR45D, THR78E, THR85D, THR89D, THR94D, TRP145D, TRP84D, TYR147D, TYR166E, TYR167E, TYR172E, TYR18D, TYR193D, TYR52E, TYR53E, TYR91D, VAL106E, VAL136D, VAL140D, VAL146D, VAL39E, VAL41E, VAL48D, VAL51E, VAL97D, VAL97E, VAL99E
• D-M: ALA105D, ALA118D, ARG57D, ARG5M, ARG77D, ASN11M, ASN12M, ASP14M, ASP157D, ASP162D, ASP75D, CYS16M, CYS2M, CYS3M, CYS8M, GLN36D, GLN55D, GLN56D, GLY1M, ILE104D, ILE116D, ILE9M, LEU10M, LEU15M, LEU163D, MET114D, PHE115D, PHE76D, PRO102D, PRO117D, PRO13M, PRO6M, PRO7M, SER101D, SER112D, SER164D, SER165D, SER4M, THR158D, THR30D, THR34D, THR78D, TYR166D, TYR53D, VAL106D, VAL107D, VAL113D
• D-N: ALA90D, ARG5N, ASN11N, ASN12N, ASN197D, ASP195D, ASP87D, CYS16N, CYS188D, CYS189D, CYS2N, CYS3N, CYS8N, GLN182D, GLN184D, GLU151D, GLU191D, GLY143D, GLY149D, GLY1N, ILE194D, ILE9N, LEU10N, LEU154D, LEU15N, LYS141D, PHE142D, PHE150D, PRO190D, PRO192D, PRO6N, PRO7N, SER144D, SER148D, SER187D, SER4N, SER92D, THR89D, TRP145D, TYR147D, TYR186D, TYR193D, TYR91D, VAL146D, VAL183D, VAL196D
• E-N: ALA105E, ALA118E, ARG57E, ARG5N, ARG77E, ASN11N, ASN12N, ASP14N, ASP157E, ASP162E, ASP75E, CYS16N, CYS2N, CYS3N, CYS8N, GLN36E, GLN55E, GLN56E, GLU54E, GLY1N, GLY32E, ILE104E, ILE116E, ILE9N, LEU10N, LEU15N, LEU163E, MET114E, PHE115E, PHE33E, PHE76E, PRO102E, PRO117E, PRO13N, PRO6N, PRO7N, SER101E, SER112E, SER164E, SER165E, SER4N, THR158E, THR30E, THR34E, THR78E, TYR166E, TYR53E, VAL106E, VAL107E, VAL113E
• E-O: ALA90E, ARG5O, ASN11O, ASN12O, ASN197E, ASP195E, ASP87E, CYS188E, CYS189E, CYS2O, CYS3O, CYS8O, GLN182E, GLN184E, GLU151E, GLU191E, GLY143E, GLY149E, GLY1O, HIS185E, ILE152E, ILE194E, ILE9O, LEU10O, LEU154E, LEU15O, LYS141E, PHE142E, PHE150E, PRO190E, PRO192E, PRO6O, PRO7O, SER144E, SER148E, SER187E, SER4O, SER92E, THR89E, TRP145E, TYR147E, TYR186E, TYR193E, TYR91E, VAL146E, VAL183E, VAL196E
• F-G: ALA105G, ALA118G, ALA139F, ALA168G, ALA2G, ALA90F, ARG120G, ARG205G, ARG6G, ARG77G, ARG95F, ARG95G, ASN3G, ASN46F, ASN61F, ASN72G, ASP126F, ASP24F, ASP25F, ASP37G, ASP42F, ASP49G, ASP75G, ASP87F, CYS125F, CYS138F, GLN103G, GLN119G, GLN1G, GLN36G, GLN98G, GLU151F, GLU191F, GLU47F, GLU54G, GLY143F, GLY20F, GLY71G, ILE104G, ILE116G, ILE38G, ILE73G, ILE88F, LEU100G, LEU121F, LEU35G, LEU4G, LEU50G, LEU60F, LEU7G, LYS171G, LYS23F, LYS40F, LYS40G, LYS8G, MET114G, MET124F, MET17F, MET5G, PHE115G, PHE123F, PHE76G, PRO102G, PRO117G, PRO127F, PRO16F, PRO19F, PRO21F, PRO86F, PRO96F, SER101G, SER122F, SER122G, SER144F, SER148F, SER15F, SER165G, SER169G, SER170G, SER43F, SER44F, SER62F, SER79G, SER92F, SER93F, SER9G, THR128F, THR137F, THR22F, THR34G, THR45F, THR78G, THR85F, THR89F, THR94F, TRP145F, TRP84F, TYR147F, TYR166G, TYR167G, TYR172G, TYR18F, TYR193F, TYR52G, TYR53G, TYR91F, VAL106G, VAL136F, VAL140F, VAL146F, VAL39G, VAL41G, VAL51G, VAL97F, VAL97G, VAL99G
• F-J: ALA105F, ALA118F, ALA139J, ALA168F, ALA2F, ALA90J, ARG120F, ARG205F, ARG6F, ARG77F, ARG95F, ARG95J, ASN13F, ASN3F, ASN46J, ASN61J, ASN72F, ASP126J, ASP24J, ASP25J, ASP37F, ASP42J, ASP49F, ASP75F, ASP87J, CYS125J, CYS138J, GLN103F, GLN119F, GLN1F, GLN36F, GLN98F, GLU151J, GLU191J, GLU47J, GLU54F, GLY143J, GLY20J, GLY71F, ILE104F, ILE116F, ILE38F, ILE73F, ILE88J, LEU100F, LEU121J, LEU35F, LEU4F, LEU50F, LEU60J, LEU7F, LYS141J, LYS171F, LYS23J, LYS40F, LYS40J, LYS8F, MET114F, MET124J, MET17J, MET5F, PHE115F, PHE123J, PHE76F, PRO102F, PRO117F, PRO127J, PRO16J, PRO19J, PRO21J, PRO86J, PRO96J, SER101F, SER122F, SER122J, SER144J, SER148J, SER15J, SER165F, SER169F, SER170F, SER43J, SER44J, SER62J, SER79F, SER92J, SER93J, SER9F, THR128J, THR137J, THR22J, THR45J, THR78F, THR85J, THR89J, THR94J, TRP145J, TRP84J, TYR147J, TYR166F, TYR167F, TYR172F, TYR18J, TYR193J, TYR52F, TYR53F, TYR91J, VAL106F, VAL140J, VAL146J, VAL39F, VAL41F, VAL48J, VAL51F, VAL97F, VAL97J, VAL99F
• F-P: ALA90F, ARG5P, ASN11P, ASN12P, ASN197F, ASP195F, ASP87F, CYS16P, CYS188F, CYS189F, CYS2P, CYS3P, CYS8P, GLN182F, GLN184F, GLU151F, GLU191F, GLY143F, GLY149F, GLY1P, HIS185F, ILE152F, ILE194F, ILE9P, LEU10P, LEU154F, LEU15P, LYS141F, PHE142F, PHE150F, PRO190F, PRO192F, PRO6P, PRO7P, SER144F, SER148F, SER187F, SER4P, SER92F, THR89F, TRP145F, TYR147F, TYR186F, TYR193F, TYR91F, VAL146F, VAL183F, VAL196F
• F-T: ALA105F, ALA118F, ARG57F, ARG5T, ARG77F, ASN11T, ASN12T, ASP14T, ASP157F, ASP162F, ASP75F, CYS16T, CYS2T, CYS3T, CYS8T, GLN179F, GLN36F, GLN55F, GLN56F, GLU54F, GLY1T, ILE104F, ILE116F, ILE9T, LEU10T, LEU15T, LEU163F, MET114F, PHE115F, PHE76F, PRO102F, PRO117F, PRO13T, PRO6T, PRO7T, SER101F, SER112F, SER164F, SER165F, SER4T, THR158F, THR30F, THR34F, THR78F, TYR166F, TYR53F, VAL106F, VAL107F, VAL113F
• G-H: ALA105H, ALA118H, ALA139G, ALA168H, ALA2H, ALA80H, ALA90G, ARG120H, ARG6H, ARG77H, ARG95G, ARG95H, ASN13H, ASN3H, ASN46G, ASN61G, ASN72H, ASP126G, ASP24G, ASP25G, ASP37H, ASP42G, ASP49H, ASP75H, ASP87G, CYS125G, CYS138G, GLN103H, GLN119H, GLN1H, GLN36H, GLN98G, GLN98H, GLU151G, GLU191G, GLU47G, GLU54H, GLY143G, GLY20G, GLY71H, ILE104H, ILE116H, ILE152G, ILE38H, ILE73H, ILE88G, LEU100H, LEU121G, LEU121H, LEU27G, LEU35H, LEU4H, LEU50H, LEU60G, LEU7H, LYS141G, LYS171H, LYS23G, LYS40G, LYS40H, LYS8H, MET114H, MET124G, MET17G, MET5H, PHE115H, PHE123G, PHE76H, PRO102H, PRO117H, PRO127G, PRO16G, PRO19G, PRO21G, PRO86G, PRO96G, SER101H, SER122G, SER122H, SER144G, SER148G, SER15G, SER165H, SER169H, SER170H, SER43G, SER44G, SER62G, SER79H, SER92G, SER93G, SER9H, THR128G, THR137G, THR22G, THR45G, THR74H, THR78H, THR85G, THR89G, THR94G, TRP145G, TRP84G, TYR147G, TYR166H, TYR167H, TYR172H, TYR18G, TYR193G, TYR52H, TYR53H, TYR91G, VAL106H, VAL136G, VAL140G, VAL146G, VAL39H, VAL41H, VAL48G, VAL51H, VAL97G, VAL97H, VAL99H
• G-P: ALA105G, ALA118G, ARG57G, ARG5P, ARG77G, ASN11P, ASN12P, ASP14P, ASP157G, ASP162G, ASP75G, CYS16P, CYS2P, CYS3P, CYS8P, GLN36G, GLN55G, GLN56G, GLY1P, GLY32G, ILE104G, ILE116G, ILE9P, LEU10P, LEU15P, LEU163G, MET114G, PHE115G, PHE76G, PRO102G, PRO117G, PRO13P, PRO6P, PRO7P, SER101G, SER112G, SER164G, SER165G, SER4P, THR108G, THR158G, THR30G, THR34G, THR78G, TYR166G, TYR53G, VAL106G, VAL107G, VAL113G
• G-Q: ALA90G, ARG5Q, ASN11Q, ASN12Q, ASN197G, ASP14Q, ASP195G, ASP87G, CYS16Q, CYS188G, CYS189G, CYS2Q, CYS3Q, CYS8Q, GLN182G, GLN184G, GLU151G, GLU191G, GLY143G, GLY149G, GLY1Q, HIS185G, ILE152G, ILE194G, ILE9Q, LEU10Q, LEU154G, LEU15Q, LYS141G, PHE142G, PHE150G, PRO190G, PRO192G, PRO6Q, PRO7Q, SER144G, SER148G, SER187G, SER4Q, SER92G, THR89G, TRP145G, TYR147G, TYR186G, TYR193G, TYR91G, VAL146G, VAL183G, VAL196G
• H-I: ALA105I, ALA118I, ALA139H, ALA168I, ALA2I, ALA80I, ALA90H, ARG120I, ARG205I, ARG6I, ARG77I, ARG95H, ARG95I, ASN13I, ASN3I, ASN46H, ASN61H, ASN72I, ASP126H, ASP24H, ASP25H, ASP37I, ASP42H, ASP49I, ASP75I, ASP87H, CYS125H, CYS138H, GLN103I, GLN119I, GLN1I, GLN36I, GLN98I, GLU151H, GLU191H, GLU47H, GLU54I, GLY143H, GLY20H, GLY71I, ILE104I, ILE116I, ILE152H, ILE38I, ILE73I, ILE88H, LEU100I, LEU121H, LEU35I, LEU4I, LEU50I, LEU60H, LEU63H, LYS141H, LYS171I, LYS23H, LYS40H, LYS40I, LYS8I, MET114I, MET124H, MET17H, MET5I, PHE115I, PHE123H, PHE12I, PHE76I, PRO102I, PRO117I, PRO127H, PRO16H, PRO19H, PRO21H, PRO86H, PRO96H, SER101I, SER122H, SER122I, SER144H, SER148H, SER15H, SER165I, SER169I, SER170I, SER43H, SER44H, SER62H, SER79I, SER92H, SER93H, SER9I, THR128H, THR137H, THR22H, THR45H, THR74I, THR78I, THR85H, THR89H, THR94H, TRP145H, TRP84H, TYR147H, TYR166I, TYR167I, TYR172I, TYR18H, TYR52I, TYR53I, TYR91H, VAL106I, VAL136H, VAL140H, VAL146H, VAL39I, VAL41I, VAL48H, VAL51I, VAL97H, VAL97I, VAL99I
• H-Q: ALA105H, ALA118H, ARG57H, ARG5Q, ARG77H, ASN11Q, ASN12Q, ASP14Q, ASP157H, ASP162H, ASP75H, CYS16Q, CYS2Q, CYS3Q, CYS8Q, GLN103H, GLN36H, GLN55H, GLN56H, GLY1Q, ILE104H, ILE116H, ILE9Q, LEU10Q, LEU15Q, LEU163H, MET114H, PHE115H, PHE33H, PRO102H, PRO117H, PRO13Q, PRO6Q, PRO7Q, SER101H, SER112H, SER164H, SER165H, SER4Q, THR108H, THR158H, THR30H, THR34H, THR78H, TYR166H, TYR53H, VAL106H, VAL107H, VAL113H
• H-R: ALA90H, ARG5R, ASN11R, ASN12R, ASN197H, ASP195H, ASP87H, CYS16R, CYS188H, CYS189H, CYS2R, CYS3R, CYS8R, GLN182H, GLN184H, GLU151H, GLU191H, GLY143H, GLY149H, GLY1R, HIS185H, ILE194H, ILE9R, LEU10R, LEU15R, LYS141H, LYS23H, PHE142H, PHE150H, PRO190H, PRO192H, PRO6R, PRO7R, SER144H, SER148H, SER187H, SER4R, SER92H, THR89H, TRP145H, TYR147H, TYR186H, TYR193H, TYR91H, VAL146H, VAL183H, VAL196H
• I-J: ALA105J, ALA118J, ALA139I, ALA168J, ALA2J, ALA90I, ARG120J, ARG205J, ARG6J, ARG77J, ARG95I, ARG95J, ASN13J, ASN3J, ASN46I, ASN61I, ASN72J, ASP126I, ASP24I, ASP25I, ASP37J, ASP42I, ASP49J, ASP75J, ASP87I, CYS125I, CYS138I, GLN103J, GLN119J, GLN1J, GLN36J, GLN98I, GLN98J, GLU151I, GLU191I, GLU47I, GLU54J, GLY143I, GLY20I, GLY71J, ILE104J, ILE116J, ILE152I, ILE38J, ILE73J, ILE88I, LEU100J, LEU121I, LEU35J, LEU4J, LEU50J, LEU60I, LEU7J, LYS141I, LYS171J, LYS23I, LYS40J, LYS8J, MET114J, MET124I, MET17I, MET5J, PHE115J, PHE123I, PHE150I, PHE76J, PRO102J, PRO117J, PRO127I, PRO16I, PRO19I, PRO21I, PRO86I, PRO96I, SER101J, SER122I, SER122J, SER144I, SER148I, SER15I, SER165J, SER169J, SER170J, SER43I, SER44I, SER62I, SER79J, SER92I, SER93I, SER9J, THR128I, THR137I, THR22I, THR34J, THR45I, THR74J, THR78J, THR85I, THR89I, THR94I, TRP145I, TRP84I, TYR147I, TYR166J, TYR167J, TYR172J, TYR18I, TYR193I, TYR52J, TYR53J, TYR91I, VAL106J, VAL136I, VAL140I, VAL146I, VAL39J, VAL41J, VAL48I, VAL51J, VAL97I, VAL97J, VAL99J
• I-O: ASP110I, HIS109I, LEU15O, THR108I
• I-R: ALA105I, ALA118I, ARG57I, ARG5R, ARG77I, ASN11R, ASN12R, ASP14R, ASP157I, ASP162I, ASP75I, CYS16R, CYS2R, CYS3R, CYS8R, GLN36I, GLN55I, GLN56I, GLU54I, GLY1R, GLY32I, ILE104I, ILE116I, ILE9R, LEU10R, LEU15R, LEU163I, MET114I, PHE115I, PHE33I, PHE76I, PRO102I, PRO117I, PRO13R, PRO6R, PRO7R, SER101I, SER112I, SER164I, SER165I, SER4R, THR158I, THR30I, THR34I, THR78I, TYR166I, TYR53I, VAL106I, VAL107I, VAL113I
• I-S: ALA90I, ARG5S, ASN11S, ASN12S, ASN197I, ASP195I, ASP87I, CYS16S, CYS188I, CYS189I, CYS2S, CYS3S, CYS8S, GLN182I, GLN184I, GLU151I, GLU191I, GLY143I, GLY149I, GLY1S, ILE152I, ILE194I, ILE9S, LEU10S, LEU154I, LEU15S, LYS141I, PHE142I, PHE150I, PRO190I, PRO192I, PRO6S, PRO7S, SER144I, SER148I, SER187I, SER4S, THR89I, TRP145I, TYR147I, TYR186I, TYR193I, TYR91I, VAL146I, VAL183I, VAL196I
• J-S: ALA105J, ALA118J, ARG57J, ARG5S, ARG77J, ASN11S, ASN12S, ASP14S, ASP157J, ASP162J, ASP75J, CYS16S, CYS2S, CYS3S, CYS8S, GLN36J, GLN55J, GLN56J, GLU54J, GLY1S, GLY32J, ILE104J, ILE116J, ILE9S, LEU10S, LEU15S, MET114J, PHE115J, PHE33J, PHE76J, PRO102J, PRO117J, PRO13S, PRO6S, PRO7S, SER101J, SER112J, SER164J, SER165J, SER4S, THR108J, THR158J, THR30J, THR34J, THR78J, TYR166J, TYR53J, VAL106J, VAL107J, VAL113J
• J-T: ALA90J, ARG5T, ASN11T, ASN12T, ASN197J, ASP195J, ASP87J, CYS16T, CYS188J, CYS189J, CYS2T, CYS3T, CYS8T, GLN182J, GLN184J, GLU151J, GLU191J, GLY143J, GLY149J, GLY1T, ILE152J, ILE194J, ILE9T, LEU10T, LEU154J, LEU15T, LYS141J, PHE142J, PHE150J, PRO190J, PRO192J, PRO6T, PRO7T, SER144J, SER148J, SER187J, SER4T, SER92J, THR89J, TRP145J, TYR147J, TYR186J, TYR193J, TYR91J, VAL146J, VAL183J, VAL196J
• O-R: ASP14O, ASP14R, LEU15O, LEU15R, PRO13O