2UYG

crystallogaphic structure of the typeii 3-dehydroquinase from thermus thermophilus

• Total interactions analyzed: 66
• Total true interactions: 30
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 65
  • Norm. En. per Res.: -4.6352
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-27.3896	-55.6279	-195.287	-278.3045	65	4	9	7059	5	13	14
A-C	-21.5985	-55.7049	-200.992	-278.2953	66	7	9	7216	5	14	15
A-D	0.0	8.5062	-0.0563	8.4499	5	0	0	14	0	6	4
A-E	-64.5781	-13.8022	-298.41	-376.7903	104	8	13	11792	2	16	39
A-H	0.0	8.522	-0.0668	8.4552	5	0	0	10	0	5	4
B-C	-23.7335	-58.2539	-202.527	-284.5144	67	9	9	7271	5	14	15
B-G	0.0	10.461	-0.1246	10.3363	5	0	0	15	0	6	4
B-H	-57.0302	-15.4771	-288.315	-360.8224	107	9	13	11632	2	16	39
B-J	0.0	15.4144	-0.4881	14.9263	5	0	0	26	0	6	4
C-E	0.0	10.7733	-0.1389	10.6344	5	0	0	15	0	6	4
C-J	-61.5303	-16.5596	-300.093	-378.1829	108	8	13	11618	2	15	39
C-L	0.0	11.4512	-0.1867	11.2645	5	0	0	15	0	6	4
D-E	-31.9748	-51.3402	-203.356	-286.671	67	4	9	7239	5	13	15
D-F	-41.659	-14.3015	-198.066	-254.0264	66	8	9	7200	5	12	14
D-H	0.0	4.8864	-0.0102	4.8763	5	0	0	5	0	6	4
D-I	-65.5331	-10.1155	-301.216	-376.8646	104	11	13	11796	0	16	39
E-F	-46.8177	-55.7827	-198.689	-301.2894	65	5	8	7204	5	13	15
E-L	0.0	9.8469	-0.1071	9.7398	5	0	0	18	0	5	4
F-I	0.0	7.9862	-0.0507	7.9355	5	0	0	13	0	6	4
F-K	0.0	7.7667	-0.0486	7.7181	5	0	0	13	0	5	4
F-L	-60.1997	-17.4016	-289.103	-366.7043	108	8	13	11628	2	15	39
G-H	-24.1705	-56.6541	-205.289	-286.1136	66	7	9	7295	5	13	15
G-I	-28.0672	-54.8675	-196.449	-279.3837	66	3	9	7071	5	13	14
G-J	0.0	10.0512	-0.1344	9.9168	5	0	0	19	0	5	4
G-K	-54.7512	-16.2312	-296.065	-367.0474	108	10	13	11686	2	15	39
H-I	-25.6301	-61.6932	-201.267	-288.5903	68	7	9	7337	5	14	16
I-K	0.0	7.8261	-0.0452	7.7809	5	0	0	13	0	5	4
J-K	-23.4589	-8.6991	-190.673	-222.831	65	7	9	7061	5	14	15
J-L	-32.305	-54.2205	-200.365	-286.8905	64	5	9	7096	5	12	14
K-L	-29.6025	-55.981	-207.274	-292.8575	67	6	9	7378	5	12	14

Interface residues

• A-B: ALA76A, ALA83B, ALA87B, ALA90B, ARG106A, ARG110A, ARG15A, ARG16A, ARG89B, ASN11A, ASN50A, ASN50B, ASN9A, ASP86B, GLN48A, GLN54A, GLN54B, GLN60B, GLN61B, GLN64B, GLN91B, GLU107A, GLU108A, GLU17A, GLU52A, GLU52B, GLU57B, GLY53A, GLY53B, GLY75A, GLY7A, HIS112A, HIS112B, HIS63B, HIS79A, ILE56B, ILE88B, LEU10A, LEU12A, LEU13A, LEU55B, LEU77A, LEU77B, LEU84B, LEU85B, PHE109A, PRO117B, PRO74A, PRO8A, PRO92B, SER81A, SER81B, THR49A, THR49B, THR78A, TRP58B, TYR21A, TYR51A, TYR51B, TYR80A, TYR80B, TYR82B, VAL114B, VAL20A, VAL59B
• A-C: ALA62A, ALA76C, ALA83A, ALA87A, ALA90A, ARG106C, ARG110C, ARG15C, ARG16C, ARG89A, ASN11C, ASN50C, ASN9C, ASP86A, GLN48C, GLN54A, GLN54C, GLN60A, GLN61A, GLN64A, GLN91A, GLU107C, GLU108C, GLU17C, GLU52A, GLU52C, GLU57A, GLY53A, GLY53C, GLY75C, GLY7C, HIS112A, HIS112C, HIS63A, HIS79C, ILE56A, ILE88A, LEU10C, LEU12C, LEU13C, LEU55A, LEU77A, LEU77C, LEU84A, LEU85A, PHE109C, PRO117A, PRO18C, PRO74C, PRO8C, PRO92A, SER81A, SER81C, THR49A, THR49C, THR78C, TRP58A, TYR21C, TYR51A, TYR51C, TYR80A, TYR80C, TYR82A, VAL114A, VAL20C, VAL59A
• A-D: ARG111A, GLU107D, GLU108A, GLU108D, PHE109D
• A-E: ALA105A, ALA105E, ALA116A, ALA116E, ALA118A, ALA118E, ALA134A, ALA134E, ALA139A, ALA139E, ARG106A, ARG106E, ARG111A, ARG111E, ARG120A, ARG120E, ASN102A, ASN102E, CYS119A, CYS119E, GLU140A, GLU140E, GLU39A, GLU97A, GLU97E, GLY121A, GLY121E, GLY125A, GLY125E, GLY127A, GLY127E, HIS104A, HIS104E, HIS112A, HIS112E, HIS79A, HIS79E, HIS99A, HIS99E, ILE122A, ILE122E, LEU100A, LEU100E, LEU103A, LEU103E, LEU129A, LEU129E, LEU133A, LEU133E, LEU135A, LEU135E, LEU138A, LEU138E, LEU32A, LEU32E, LEU40A, LEU40E, LEU85A, LEU85E, LYS132A, LYS132E, PHE126A, PHE126E, PRO117A, PRO117E, PRO128A, PRO128E, PRO94A, PRO94E, SER113A, SER113E, SER124A, SER124E, SER130A, SER130E, THR101A, THR101E, THR115A, THR115E, THR141A, THR141E, THR78A, THR78E, TRP36A, TRP36E, TYR131A, TYR131E, TYR137A, TYR137E, TYR82A, TYR82E, VAL114A, VAL114E, VAL123A, VAL123E, VAL136A, VAL136E, VAL71A, VAL95A, VAL95E, VAL96A, VAL96E, VAL98A, VAL98E
• A-H: ARG111H, GLU107A, GLU108A, GLU108H, PHE109A
• B-C: ALA118C, ALA62C, ALA76B, ALA83C, ALA87C, ALA90C, ARG106B, ARG110B, ARG15B, ARG16B, ARG89C, ASN11B, ASN50B, ASN50C, ASN9B, ASP86C, GLN48B, GLN54B, GLN54C, GLN60C, GLN61C, GLN64C, GLN91C, GLU107B, GLU108B, GLU17B, GLU52B, GLU52C, GLU57C, GLY53B, GLY53C, GLY75B, GLY7B, HIS112B, HIS112C, HIS63C, HIS79B, ILE56C, ILE88C, LEU10B, LEU12B, LEU13B, LEU55C, LEU77B, LEU77C, LEU84C, LEU85C, PHE109B, PRO117C, PRO74B, PRO8B, PRO92C, SER81B, SER81C, THR49B, THR49C, THR78B, TRP58C, TYR21B, TYR51B, TYR51C, TYR80B, TYR80C, TYR82C, VAL114C, VAL20B, VAL59C
• B-G: ARG111B, GLU107G, GLU108B, GLU108G, PHE109G
• B-H: ALA105B, ALA105H, ALA116B, ALA116H, ALA118B, ALA118H, ALA134B, ALA134H, ALA139B, ALA139H, ARG106B, ARG106H, ARG111B, ARG111H, ARG120B, ARG120H, ARG89B, ASN102B, ASN102H, CYS119B, CYS119H, GLU108H, GLU140B, GLU140H, GLU39B, GLU97B, GLU97H, GLY121B, GLY121H, GLY125B, GLY125H, GLY127B, GLY127H, HIS104B, HIS104H, HIS112B, HIS112H, HIS79B, HIS79H, HIS99B, HIS99H, ILE122B, ILE122H, ILE88B, LEU100B, LEU100H, LEU103B, LEU103H, LEU129B, LEU129H, LEU133B, LEU133H, LEU135B, LEU135H, LEU138B, LEU138H, LEU32H, LEU40B, LEU40H, LEU85B, LEU85H, LYS132B, LYS132H, PHE126B, PHE126H, PRO117B, PRO117H, PRO128B, PRO128H, PRO94B, PRO94H, SER113B, SER113H, SER124B, SER124H, SER130B, SER130H, THR101B, THR101H, THR115B, THR115H, THR141B, THR141H, THR78B, THR78H, TRP36B, TRP36H, TYR131B, TYR131H, TYR137B, TYR137H, TYR82B, TYR82H, VAL114B, VAL114H, VAL123B, VAL123H, VAL136B, VAL136H, VAL71B, VAL71H, VAL95B, VAL95H, VAL96B, VAL96H, VAL98B, VAL98H
• B-J: ARG111J, GLU107B, GLU108B, GLU108J, PHE109B
• C-E: ARG111E, GLU107C, GLU108C, GLU108E, PHE109C
• C-J: ALA105C, ALA105J, ALA116C, ALA116J, ALA118C, ALA118J, ALA134C, ALA134J, ALA139C, ALA139J, ARG106C, ARG106J, ARG111C, ARG111J, ARG120C, ARG120J, ARG89C, ASN102C, ASN102J, CYS119C, CYS119J, GLU140C, GLU140J, GLU39C, GLU39J, GLU97C, GLU97J, GLY121C, GLY121J, GLY125C, GLY125J, GLY127C, GLY127J, HIS104C, HIS104J, HIS112C, HIS112J, HIS79C, HIS79J, HIS99C, HIS99J, ILE122C, ILE122J, ILE88C, LEU100C, LEU100J, LEU103C, LEU103J, LEU129C, LEU129J, LEU133C, LEU133J, LEU135C, LEU135J, LEU138C, LEU138J, LEU32C, LEU32J, LEU40C, LEU40J, LEU85C, LEU85J, LYS132C, LYS132J, PHE126C, PHE126J, PRO117C, PRO117J, PRO128C, PRO128J, PRO94C, PRO94J, SER113C, SER113J, SER124C, SER124J, SER130C, SER130J, THR101C, THR101J, THR115C, THR115J, THR141C, THR141J, THR78C, THR78J, TRP36C, TRP36J, TYR131C, TYR131J, TYR137C, TYR137J, TYR82C, TYR82J, VAL114C, VAL114J, VAL123C, VAL123J, VAL136C, VAL136J, VAL71C, VAL71J, VAL95C, VAL95J, VAL96C, VAL96J, VAL98C, VAL98J
• C-L: ARG111C, GLU107L, GLU108C, GLU108L, PHE109L
• D-E: ALA118E, ALA62E, ALA76D, ALA83E, ALA87E, ALA90E, ARG106D, ARG110D, ARG15D, ARG16D, ARG89E, ASN11D, ASN50D, ASN50E, ASN9D, ASP86E, GLN48D, GLN54D, GLN54E, GLN60E, GLN61E, GLN64E, GLN91E, GLU107D, GLU17D, GLU52D, GLU52E, GLU57E, GLY53D, GLY53E, GLY75D, GLY7D, HIS112D, HIS112E, HIS63E, HIS79D, ILE56E, ILE88E, LEU10D, LEU12D, LEU13D, LEU55E, LEU77D, LEU77E, LEU84E, LEU85E, PHE109D, PRO117E, PRO18D, PRO74D, PRO8D, PRO92E, SER81D, SER81E, THR49D, THR49E, THR78D, TRP58E, TYR21D, TYR51D, TYR51E, TYR80D, TYR80E, TYR82E, VAL114E, VAL20D, VAL59E
• D-F: ALA62D, ALA76F, ALA83D, ALA87D, ALA90D, ARG106F, ARG110F, ARG15F, ARG16F, ARG89D, ASN11F, ASN50D, ASN50F, ASN9F, ASP86D, GLN48F, GLN54D, GLN54F, GLN60D, GLN61D, GLN64D, GLN91D, GLU107F, GLU108F, GLU17F, GLU52D, GLU52F, GLU57D, GLY53D, GLY53F, GLY75F, GLY7F, HIS112D, HIS112F, HIS63D, HIS79F, ILE56D, ILE88D, LEU10F, LEU12F, LEU13F, LEU55D, LEU77D, LEU77F, LEU84D, LEU85D, PHE109F, PRO117D, PRO74F, PRO8F, PRO92D, SER81D, SER81F, THR49D, THR49F, THR78F, TRP58D, TYR21F, TYR51D, TYR51F, TYR80D, TYR80F, TYR82D, VAL114D, VAL20F, VAL59D
• D-H: ARG111D, GLU107H, GLU108D, GLU108H, PHE109H
• D-I: ALA105D, ALA105I, ALA116D, ALA116I, ALA118D, ALA118I, ALA134D, ALA134I, ALA139D, ALA139I, ARG106D, ARG106I, ARG111D, ARG111I, ARG120D, ARG120I, ASN102D, ASN102I, CYS119D, CYS119I, GLU140D, GLU140I, GLU39D, GLU97D, GLU97I, GLY121D, GLY121I, GLY125D, GLY125I, GLY127D, GLY127I, HIS104D, HIS104I, HIS112D, HIS112I, HIS79D, HIS79I, HIS99D, HIS99I, ILE122D, ILE122I, LEU100D, LEU100I, LEU103D, LEU103I, LEU129D, LEU129I, LEU133D, LEU133I, LEU135D, LEU135I, LEU138D, LEU138I, LEU32D, LEU32I, LEU40D, LEU40I, LEU85D, LYS132D, LYS132I, PHE126D, PHE126I, PRO117D, PRO117I, PRO128D, PRO128I, PRO94D, PRO94I, SER113D, SER113I, SER124D, SER124I, SER130D, SER130I, THR101D, THR101I, THR115D, THR115I, THR141D, THR141I, THR78D, THR78I, TRP36D, TRP36I, TYR131D, TYR131I, TYR137D, TYR137I, TYR82D, TYR82I, VAL114D, VAL114I, VAL123D, VAL123I, VAL136D, VAL136I, VAL71D, VAL71I, VAL95D, VAL95I, VAL96D, VAL96I, VAL98D, VAL98I
• E-F: ALA118F, ALA62F, ALA76E, ALA83F, ALA87F, ALA90F, ARG106E, ARG110E, ARG15E, ARG16E, ARG89F, ASN11E, ASN50E, ASN50F, ASN9E, ASP86F, GLN48E, GLN54E, GLN54F, GLN60F, GLN61F, GLN64F, GLN91F, GLU107E, GLU17E, GLU52E, GLU52F, GLU57F, GLY53E, GLY53F, GLY75E, GLY7E, HIS112E, HIS63F, HIS79E, ILE56F, ILE88F, LEU10E, LEU12E, LEU13E, LEU55F, LEU77E, LEU77F, LEU84F, LEU85F, PHE109E, PRO117F, PRO74E, PRO8E, PRO92F, SER81E, SER81F, THR49E, THR49F, THR78E, TRP58F, TYR21E, TYR51E, TYR51F, TYR80E, TYR80F, TYR82F, VAL114F, VAL20E, VAL59F
• E-L: ARG111L, GLU107E, GLU108E, GLU108L, PHE109E
• F-I: ARG111I, GLU107F, GLU108F, GLU108I, PHE109F
• F-K: ARG111F, GLU107K, GLU108F, GLU108K, PHE109K
• F-L: ALA105F, ALA105L, ALA116F, ALA116L, ALA118F, ALA118L, ALA134F, ALA134L, ALA139F, ALA139L, ARG106F, ARG106L, ARG111F, ARG111L, ARG120F, ARG120L, ARG89F, ARG89L, ASN102F, ASN102L, CYS119F, CYS119L, GLU140F, GLU140L, GLU39F, GLU39L, GLU97F, GLU97L, GLY121F, GLY121L, GLY125F, GLY125L, GLY127F, GLY127L, HIS104F, HIS104L, HIS112F, HIS112L, HIS79F, HIS79L, HIS99F, HIS99L, ILE122F, ILE122L, LEU100F, LEU100L, LEU103F, LEU103L, LEU129F, LEU129L, LEU133F, LEU133L, LEU135F, LEU135L, LEU138F, LEU138L, LEU32F, LEU32L, LEU40F, LEU40L, LEU85F, LEU85L, LYS132F, LYS132L, PHE126F, PHE126L, PRO117F, PRO117L, PRO128F, PRO128L, PRO94F, PRO94L, SER113F, SER113L, SER124F, SER124L, SER130F, SER130L, THR101F, THR101L, THR115F, THR115L, THR141F, THR141L, THR78F, THR78L, TRP36F, TRP36L, TYR131F, TYR131L, TYR137F, TYR137L, TYR82F, TYR82L, VAL114F, VAL114L, VAL123F, VAL123L, VAL136F, VAL136L, VAL71F, VAL71L, VAL95F, VAL95L, VAL96F, VAL96L, VAL98F, VAL98L
• G-H: ALA62H, ALA76G, ALA83H, ALA87H, ALA90H, ARG106G, ARG110G, ARG15G, ARG16G, ARG89H, ASN11G, ASN50G, ASN50H, ASN9G, ASP86H, GLN48G, GLN54G, GLN54H, GLN60H, GLN61H, GLN64H, GLN91H, GLU107G, GLU108G, GLU17G, GLU52G, GLU52H, GLU57H, GLY53G, GLY53H, GLY75G, GLY7G, HIS112G, HIS112H, HIS63H, HIS79G, ILE56H, ILE88H, LEU10G, LEU12G, LEU13G, LEU55H, LEU77G, LEU77H, LEU84H, LEU85H, PHE109G, PRO117H, PRO74G, PRO8G, PRO92H, SER81G, SER81H, THR49G, THR49H, THR78G, TRP58H, TYR21G, TYR51G, TYR51H, TYR80G, TYR80H, TYR82H, VAL114H, VAL20G, VAL59H
• G-I: ALA118G, ALA76I, ALA83G, ALA87G, ALA90G, ARG106I, ARG110I, ARG15I, ARG16I, ARG89G, ASN11I, ASN50I, ASN9I, ASP86G, GLN48I, GLN54G, GLN54I, GLN60G, GLN61G, GLN64G, GLN91G, GLU107I, GLU108I, GLU17I, GLU52G, GLU52I, GLU57G, GLY14I, GLY53G, GLY53I, GLY75I, GLY7I, HIS112G, HIS112I, HIS63G, HIS79I, ILE56G, ILE88G, LEU10I, LEU12I, LEU13I, LEU55G, LEU77G, LEU77I, LEU84G, LEU85G, PHE109I, PRO117G, PRO74I, PRO8I, PRO92G, SER81G, SER81I, THR49G, THR49I, THR78I, TRP58G, TYR21I, TYR51G, TYR51I, TYR80G, TYR80I, TYR82G, VAL114G, VAL20I, VAL59G
• G-J: ARG111G, GLU107J, GLU108G, GLU108J, PHE109J
• G-K: ALA105G, ALA105K, ALA116G, ALA116K, ALA118G, ALA118K, ALA134G, ALA134K, ALA139G, ALA139K, ARG106G, ARG106K, ARG111G, ARG111K, ARG120G, ARG120K, ARG89K, ASN102G, ASN102K, CYS119G, CYS119K, GLU108K, GLU140G, GLU140K, GLU39G, GLU39K, GLU97G, GLU97K, GLY121G, GLY121K, GLY125G, GLY125K, GLY127G, GLY127K, HIS104G, HIS104K, HIS112G, HIS112K, HIS79G, HIS79K, HIS99G, HIS99K, ILE122G, ILE122K, LEU100G, LEU100K, LEU103G, LEU103K, LEU129G, LEU129K, LEU133G, LEU133K, LEU135G, LEU135K, LEU138G, LEU138K, LEU32G, LEU32K, LEU40G, LEU40K, LEU85G, LEU85K, LYS132G, LYS132K, PHE126G, PHE126K, PRO117G, PRO117K, PRO128G, PRO128K, PRO94G, PRO94K, SER113G, SER113K, SER124G, SER124K, SER130G, SER130K, THR101G, THR101K, THR115G, THR115K, THR141G, THR141K, THR78G, THR78K, TRP36G, TRP36K, TYR131G, TYR131K, TYR137G, TYR137K, TYR82G, TYR82K, VAL114G, VAL114K, VAL123G, VAL123K, VAL136G, VAL136K, VAL71G, VAL71K, VAL95G, VAL95K, VAL96G, VAL96K, VAL98G, VAL98K
• H-I: ALA118I, ALA62I, ALA76H, ALA83I, ALA87I, ALA90I, ARG106H, ARG110H, ARG15H, ARG16H, ARG89I, ASN11H, ASN50H, ASN50I, ASN9H, ASP86I, GLN48H, GLN54H, GLN54I, GLN60I, GLN61I, GLN64I, GLN91I, GLU107H, GLU108H, GLU17H, GLU52H, GLU52I, GLU57I, GLY53H, GLY53I, GLY75H, GLY7H, HIS112H, HIS112I, HIS63I, HIS79H, ILE56I, ILE88I, LEU10H, LEU12H, LEU13H, LEU55I, LEU77H, LEU77I, LEU84I, LEU85I, PHE109H, PRO117I, PRO18H, PRO74H, PRO8H, PRO92I, SER81H, SER81I, THR49H, THR49I, THR78H, TRP58I, TYR21H, TYR51H, TYR51I, TYR80H, TYR80I, TYR82I, VAL114I, VAL20H, VAL59I
• I-K: ARG111K, GLU107I, GLU108I, GLU108K, PHE109I
• J-K: ALA62K, ALA76J, ALA83K, ALA87K, ALA90K, ARG106J, ARG110J, ARG15J, ARG16J, ARG89K, ASN11J, ASN50J, ASN50K, ASN9J, ASP86K, GLN48J, GLN54J, GLN54K, GLN60K, GLN61K, GLN64K, GLN91K, GLU107J, GLU108J, GLU17J, GLU52J, GLU52K, GLU57K, GLY53J, GLY53K, GLY75J, GLY7J, HIS112J, HIS63K, HIS79J, ILE56K, ILE88K, LEU10J, LEU12J, LEU13J, LEU55K, LEU77J, LEU77K, LEU84K, LEU85K, PHE109J, PRO117K, PRO74J, PRO8J, PRO92K, SER81J, SER81K, THR49J, THR49K, THR78J, TRP58K, TYR21J, TYR51J, TYR51K, TYR80J, TYR80K, TYR82K, VAL114K, VAL20J, VAL59K
• J-L: ALA62J, ALA76L, ALA83J, ALA87J, ALA90J, ARG106L, ARG110L, ARG15L, ARG16L, ARG89J, ASN11L, ASN50J, ASN50L, ASN9L, ASP86J, GLN48L, GLN54J, GLN54L, GLN60J, GLN61J, GLN64J, GLN91J, GLU107L, GLU17L, GLU52J, GLU52L, GLU57J, GLY53J, GLY53L, GLY75L, GLY7L, HIS112L, HIS63J, HIS79L, ILE56J, ILE88J, LEU10L, LEU12L, LEU13L, LEU55J, LEU77J, LEU77L, LEU84J, LEU85J, PHE109L, PRO117J, PRO74L, PRO8L, PRO92J, SER81J, SER81L, THR49J, THR49L, THR78L, TRP58J, TYR21L, TYR51J, TYR51L, TYR80J, TYR80L, TYR82J, VAL114J, VAL20L, VAL59J
• K-L: ALA118L, ALA62L, ALA76K, ALA83L, ALA87L, ALA90L, ARG106K, ARG110K, ARG15K, ARG16K, ARG89L, ASN11K, ASN50K, ASN50L, ASN9K, ASP86L, GLN48K, GLN54K, GLN54L, GLN60L, GLN61L, GLN64L, GLN91L, GLU107K, GLU108K, GLU17K, GLU52K, GLU52L, GLU57L, GLY14K, GLY53K, GLY53L, GLY75K, GLY7K, HIS112K, HIS63L, HIS79K, ILE56L, ILE88L, LEU10K, LEU12K, LEU13K, LEU55L, LEU77K, LEU77L, LEU84L, LEU85L, PHE109K, PRO117L, PRO74K, PRO8K, PRO92L, SER81K, SER81L, THR49K, THR49L, THR78K, TRP58L, TYR21K, TYR51K, TYR51L, TYR80K, TYR80L, TYR82L, VAL114L, VAL20K, VAL59L