2TNF

1.4 a resolution structure of mouse tumor necrosis factor, towards modulation of its selctivity and trimerisation

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 103
  • Norm. En. per Res.: -3.031
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-47.7188	-5.2976	-270.399	-323.4154	111	9	9	11394	0	16	14
A-C	-42.9139	6.652	-255.639	-291.9009	109	18	10	11468	0	15	15
B-C	-37.9624	1.3167	-275.548	-312.1936	103	12	9	11809	0	14	14

Interface residues

• A-B: ALA145B, ALA14B, ALA156A, ALA156B, ALA33B, ALA35B, ALA38B, ALA84A, ALA96A, ARG32B, ARG82A, ASN34B, ASN39B, ASN92A, ASP104A, ASP10B, ASP143B, ASP53A, ASP71A, CYS101A, CYS101B, CYS69B, GLN125A, GLN149B, GLN61B, GLN67B, GLU107B, GLU116A, GLU116B, GLU146B, GLY121A, GLY121B, GLY122A, GLY148B, GLY153B, GLY54A, GLY66B, GLY68B, HIS15B, HIS78A, ILE118A, ILE118B, ILE155A, ILE155B, LEU111B, LEU120A, LEU120B, LEU126A, LEU157A, LEU157B, LEU36B, LEU37B, LEU55A, LEU57A, LEU57B, LEU63B, LEU75A, LEU76A, LEU93A, LEU94A, LYS103A, LYS112B, LYS11A, LYS11B, LYS65B, LYS90A, LYS98A, LYS98B, PHE124A, PHE152B, PHE64A, PHE64B, PRO100A, PRO100B, PRO102A, PRO102B, PRO106B, PRO113B, PRO117A, PRO117B, PRO12B, SER147B, SER60A, SER60B, SER81A, SER95A, SER99A, SER9B, THR77A, THR79A, TRP114B, TYR115B, TYR119A, TYR119B, TYR151B, TYR56A, TYR59A, TYR59B, TYR72A, TYR87A, VAL123A, VAL13B, VAL150B, VAL154B, VAL17B, VAL58A, VAL62B, VAL74A, VAL80A, VAL91A, VAL97A
• A-C: ALA109A, ALA145A, ALA14A, ALA156A, ALA33A, ALA35A, ALA38A, ALA96C, ARG32A, ARG82C, ASN34A, ASN39A, ASN92C, ASP104C, ASP10A, ASP130C, ASP143A, CYS101C, CYS69C, GLN125C, GLN149A, GLN61A, GLN67A, GLU110A, GLU116A, GLU116C, GLU146A, GLY121A, GLY121C, GLY122C, GLY148A, GLY153A, GLY54C, GLY66A, GLY68A, HIS15A, HIS78C, ILE118A, ILE118C, ILE155A, ILE155C, LEU111A, LEU120A, LEU120C, LEU126C, LEU157A, LEU157C, LEU36A, LEU37A, LEU55C, LEU57A, LEU57C, LEU63A, LEU75C, LEU76C, LEU93C, LEU94C, LYS103A, LYS103C, LYS112A, LYS11A, LYS11C, LYS65A, LYS98A, LYS98C, PHE124C, PHE152A, PHE64A, PHE64C, PRO100A, PRO100C, PRO102C, PRO106C, PRO113A, PRO117A, PRO117C, PRO12A, SER147A, SER60A, SER60C, SER81C, SER95C, SER99C, SER9A, THR105A, THR105C, THR77C, THR79C, TRP114A, TYR115A, TYR119A, TYR119C, TYR151A, TYR56C, TYR59A, TYR59C, TYR72C, TYR87C, VAL123C, VAL13A, VAL150A, VAL154A, VAL17A, VAL58C, VAL62A, VAL74C, VAL80C, VAL91C, VAL97C
• B-C: ALA109C, ALA145C, ALA14C, ALA156B, ALA156C, ALA33C, ALA35C, ALA38C, ALA96B, ARG82B, ASN34C, ASN39C, ASN92B, ASP104B, ASP10C, ASP143C, ASP71B, CYS101B, GLN125B, GLN149C, GLN61C, GLN67C, GLU107C, GLU110C, GLU116B, GLU116C, GLU146C, GLY121B, GLY121C, GLY122B, GLY148C, GLY153C, GLY54B, GLY66C, HIS15C, HIS78B, ILE118B, ILE118C, ILE155B, ILE155C, LEU111C, LEU120B, LEU120C, LEU126B, LEU157B, LEU157C, LEU36C, LEU37C, LEU55B, LEU57B, LEU57C, LEU63C, LEU75B, LEU76B, LEU93B, LEU94B, LYS103B, LYS112C, LYS11B, LYS11C, LYS65C, LYS90B, LYS98B, LYS98C, PHE124B, PHE152C, PHE64C, PRO100B, PRO102B, PRO106C, PRO113C, PRO117B, PRO117C, PRO12C, SER147C, SER60B, SER60C, SER81B, SER95B, SER99B, THR77B, THR79B, TRP114C, TYR115C, TYR119B, TYR119C, TYR151C, TYR56B, TYR59B, TYR59C, TYR72B, TYR87B, VAL123B, VAL13C, VAL150C, VAL154C, VAL17C, VAL58B, VAL62C, VAL74B, VAL80B, VAL91B, VAL97B