2RFD

crystal structure of the complex between the egfr kinase domain and a mig6 peptide

• Total interactions analyzed: 6
• Total true interactions: 4
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 61
  • Norm. En. per Res.: -4.7202
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-36.3568	-124.531	-104.494	-265.3818	71	24	2	5323	11	52	57
A-C	-48.6423	-0.1761	-206.442	-255.2604	62	18	1	7774	0	9	7
B-C	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	1	2
B-D	-73.093	0.863	-215.704	-287.934	61	23	1	7723	0	9	7

Interface residues

• A-B: ALA798B, ALA931A, ALA931B, ARG807A, ARG807B, ARG808A, ARG808B, ARG812A, ARG865A, ARG934A, ARG934B, ARG938B, ARG949B, ASN747B, ASN802B, ASP806B, ASP872A, ASP930A, ASP932A, ASP932B, GLN796B, GLN870A, GLN870B, GLU734A, GLU738A, GLU799B, GLU805A, GLU805B, GLU860A, GLU939B, GLU943B, GLY800B, GLY839A, HIS749B, HIS811A, HIS864A, HIS869A, HIS869B, ILE866A, ILE929A, ILE941B, ILE942B, LEU804A, LEU809A, LEU863A, LEU940B, LYS730A, LYS836A, LYS925B, LYS936A, LYS936B, LYS946B, MET928A, MET947B, PHE832A, PHE937B, PHE944B, PRO729A, PRO748B, PRO935B, SER871A, SER933A, SER933B, SER945B, THR868A, TYR803B, TYR867A, VAL741A, VAL795B, VAL810A, VAL873B
• A-C: ALA353C, ARG908A, ARG934A, ASP355C, ASP892A, ASP930A, CYS915A, CYS926A, GLN350C, GLN911A, GLU904A, GLU907A, GLY893A, GLY906A, ILE894A, ILE899A, ILE902A, ILE914A, ILE917A, ILE922A, ILE929A, LEU859A, LEU863A, LEU903A, LEU909A, LYS357C, LYS855A, LYS889A, LYS905A, LYS925A, MET346C, MET884A, MET921A, MET923A, MET928A, PHE352C, PHE886A, PRO347C, PRO348C, PRO354C, PRO356C, PRO890A, PRO910A, PRO912A, PRO913A, SER351C, SER360C, SER361C, SER888A, SER900A, SER901A, SER933A, THR349C, THR885A, TRP874A, TRP881A, TRP927A, TYR358C, TYR891A, TYR920A, VAL359C, VAL924A
• B-C: ARG949B, LYS357C
• B-D: ALA353D, ARG908B, ARG934B, ASP355D, ASP892B, ASP930B, CYS926B, GLN350D, GLN911B, GLU882B, GLU904B, GLU907B, GLY893B, GLY906B, ILE894B, ILE899B, ILE902B, ILE914B, ILE917B, ILE922B, ILE929B, LEU859B, LEU863B, LEU903B, LEU909B, LYS357D, LYS889B, LYS905B, LYS925B, MET346D, MET884B, MET921B, MET923B, MET928B, PHE352D, PHE886B, PRO347D, PRO348D, PRO354D, PRO356D, PRO890B, PRO910B, PRO912B, PRO913B, PRO935B, SER351D, SER360D, SER888B, SER900B, SER901B, SER933B, THR349D, THR885B, TRP874B, TRP881B, TRP927B, TYR358D, TYR891B, TYR920B, VAL359D, VAL924B