2RF9

crystal structure of the complex between the egfr kinase domain and a mig6 peptide

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 78
  • Norm. En. per Res.: -4.5604
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-92.8005	0.0	-262.912	-355.7125	78	39	3	10573	0	16	10
A-D	0.0	0.0	-8.8953	-8.8953	14	0	0	601	0	2	1
B-C	0.0	0.0	-4.6513	-4.6513	16	0	0	458	0	3	1
B-D	-58.0677	0.0	-257.377	-315.4447	81	16	2	9615	0	12	9
C-D	0.0	0.0	-68.7812	-68.7812	45	2	0	3068	0	1	2

Interface residues

• A-C: ALA353C, ARG908A, ARG934A, ARG953A, ASP355C, ASP892A, ASP918A, ASP930A, CYS915A, CYS926A, GLN350C, GLN911A, GLN952A, GLU882A, GLU898A, GLU904A, GLU907A, GLY344C, GLY893A, GLY906A, ILE894A, ILE899A, ILE902A, ILE914A, ILE917A, ILE929A, ILE957A, LEU338C, LEU859A, LEU863A, LEU903A, LEU909A, LEU955A, LYS336C, LYS357C, LYS362C, LYS889A, LYS905A, LYS925A, MET346C, MET921A, MET923A, MET928A, PHE352C, PRO339C, PRO347C, PRO348C, PRO354C, PRO356C, PRO890A, PRO910A, PRO912A, PRO913A, PRO935A, SER337C, SER340C, SER351C, SER360C, SER361C, SER888A, SER900A, SER933A, THR349C, THR885A, THR916A, TRP874A, TRP881A, TRP927A, TYR341C, TYR358C, TYR891A, TYR920A, TYR954A, VAL345C, VAL359C, VAL919A, VAL924A, VAL956A
• A-D: ALA353D, ASP355D, CYS915A, GLN911A, ILE917A, LYS357D, PRO354D, PRO356D, PRO910A, PRO912A, PRO913A, THR916A, TYR358D, TYR920A
• B-C: ALA353C, ASP355C, CYS915B, GLN911B, GLU904B, ILE917B, LEU342C, LYS905B, PHE352C, PRO354C, PRO356C, PRO910B, PRO912B, PRO913B, SER340C, TYR920B
• B-D: ALA353D, ARG908B, ARG934B, ARG953B, ASN343D, ASP355D, ASP892B, ASP918B, ASP930B, CYS915B, CYS926B, GLN350D, GLN911B, GLU882B, GLU904B, GLU907B, GLY344D, GLY887B, GLY893B, GLY906B, HIS864B, ILE894B, ILE899B, ILE902B, ILE914B, ILE917B, ILE922B, ILE929B, ILE957B, LEU338D, LEU859B, LEU863B, LEU903B, LEU909B, LEU955B, LYS357D, LYS362D, LYS889B, LYS905B, LYS925B, MET346D, MET884B, MET921B, MET923B, MET928B, PHE352D, PHE886B, PRO339D, PRO347D, PRO348D, PRO354D, PRO356D, PRO890B, PRO910B, PRO912B, PRO913B, PRO935B, SER337D, SER340D, SER351D, SER360D, SER361D, SER888B, SER900B, SER933B, THR349D, THR885B, THR916B, TRP874B, TRP881B, TRP927B, TYR341D, TYR358D, TYR891B, TYR920B, TYR954B, VAL345D, VAL359D, VAL919B, VAL924B, VAL956B
• C-D: ALA353C, ALA353D, ASP355C, ASP355D, GLN350C, GLN350D, LEU338C, LEU338D, LEU342C, LEU342D, LYS336C, LYS357C, LYS357D, LYS362C, LYS362D, MET346C, MET346D, PHE352C, PHE352D, PRO339C, PRO339D, PRO347C, PRO347D, PRO354C, PRO354D, PRO356C, PRO356D, SER337C, SER337D, SER340C, SER340D, SER351C, SER351D, SER360C, SER360D, SER361C, SER361D, THR349C, TYR341C, TYR341D, TYR358C, TYR358D, VAL345C, VAL359C, VAL359D