2QTS

structure of an acid-sensing ion channel 1 at 1.9 a resolution and low ph

• Total interactions analyzed: 15
• Total true interactions: 8
• Strongest Interaction:
  • Chains: D-F
  • Int. Res.: 264
  • Norm. En. per Res.: -3.6775
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-173.2092	-121.5775	-594.846	-889.6327	249	39	21	25281	10	71	53
A-C	-170.06	-134.0108	-665.708	-969.7788	265	35	29	27496	10	71	55
A-E	0.0	0.2969	-49.1214	-48.8245	48	1	0	2392	0	15	19
A-F	0.0	-1.1378	-2.0316	-3.1694	20	0	0	255	0	6	3
B-C	-194.547	-143.7209	-562.781	-901.0489	257	37	24	25072	13	67	53
D-E	-153.7715	-113.4771	-611.501	-878.7496	240	40	20	25358	8	74	52
D-F	-191.8782	-128.8055	-650.173	-970.8567	264	38	29	26807	10	68	53
E-F	-193.3714	-140.3039	-597.651	-931.3263	259	35	22	26103	12	72	53

Interface residues

• A-B: ALA117B, ALA131B, ALA244B, ALA267B, ALA384A, ALA386A, ALA413A, ALA424B, ALA428A, ALA456A, ALA48B, ALA56B, ALA82A, ALA83A, ARG176A, ARG191B, ARG310B, ARG370A, ARG370B, ARG44B, ARG65B, ARG85A, ASN217A, ASN357B, ASN403B, ASN415A, ASN64B, ASN97B, ASP127B, ASP132B, ASP228B, ASP260B, ASP290B, ASP350B, ASP356B, ASP408A, ASP433A, ASP433B, ASP454A, ASP79A, CYS276A, CYS276B, CYS291B, CYS313B, CYS360B, CYS362B, CYS50B, GLN129B, GLN135B, GLN179A, GLN226B, GLN227B, GLN249B, GLN261B, GLN271A, GLN277A, GLN277B, GLN279A, GLN279B, GLN398B, GLN421B, GLN437A, GLN437B, GLU133B, GLU178A, GLU220A, GLU229B, GLU236B, GLU243B, GLU255B, GLU314B, GLU354B, GLU358B, GLU363B, GLU374A, GLU374B, GLU397A, GLU402B, GLU412A, GLU417A, GLU417B, GLU420B, GLU451A, GLU451B, GLU458A, GLU80A, GLY177A, GLY213A, GLY214A, GLY216A, GLY218A, GLY235B, GLY245B, GLY263B, GLY265B, GLY269A, GLY269B, GLY372A, GLY372B, GLY401B, GLY429A, GLY432A, GLY435A, GLY436A, GLY436B, GLY439A, GLY443A, GLY53B, HIS74B, ILE209A, ILE225B, ILE246B, ILE259B, ILE282B, ILE306B, ILE380A, ILE400A, ILE404A, ILE419A, ILE419B, ILE434A, ILE434B, ILE442A, ILE446A, LEU118B, LEU231B, LEU258B, LEU262B, LEU281B, LEU349B, LEU352B, LEU375A, LEU375B, LEU389A, LEU405A, LEU405B, LEU414A, LEU42B, LEU430A, LEU431A, LEU440A, LEU440B, LEU447A, LEU447B, LEU450A, LEU452A, LEU49B, LEU55B, LEU57B, LEU58B, LEU60B, LEU78A, LEU78B, LEU96B, LYS134B, LYS212A, LYS247B, LYS355B, LYS373A, LYS373B, LYS379A, LYS379B, LYS383A, LYS387A, LYS391A, LYS392A, LYS43B, LYS77A, LYS77B, MET211A, MET222A, MET364B, MET377A, MET377B, MET438A, MET52B, PHE101B, PHE174A, PHE175A, PHE242B, PHE264B, PHE270A, PHE270B, PHE273A, PHE351B, PHE410A, PHE411A, PHE453A, PHE51B, PRO232B, PRO268B, PRO365B, PRO381A, PRO73B, SER172A, SER241B, SER275A, SER275B, SER376A, SER376B, SER382A, SER385A, SER445A, SER54B, THR130B, THR210A, THR215A, THR240B, THR272A, THR272B, THR307B, THR369B, THR418A, THR418B, THR448A, THR76A, THR76B, THR84A, TRP234B, TRP47B, TYR192B, TYR230B, TYR283B, TYR359B, TYR371B, TYR388A, TYR393A, TYR399B, TYR416A, TYR425A, TYR457A, TYR68B, VAL233B, VAL248B, VAL266B, VAL274A, VAL274B, VAL353B, VAL361B, VAL368B, VAL378A, VAL406A, VAL449A, VAL45B, VAL46B, VAL61B, VAL75A, VAL75B, VAL81A
• A-C: ALA117A, ALA131A, ALA244A, ALA267A, ALA384C, ALA386C, ALA390C, ALA413C, ALA424A, ALA428C, ALA444A, ALA444C, ALA48A, ALA56A, ALA82C, ALA83C, ARG176C, ARG191A, ARG310A, ARG370A, ARG44A, ARG65A, ARG85C, ASN217C, ASN357A, ASN403A, ASN415C, ASN64A, ASN97A, ASP127A, ASP132A, ASP228A, ASP260A, ASP290A, ASP350A, ASP356A, ASP408C, ASP433A, ASP433C, ASP454C, ASP79A, ASP79C, CYS276A, CYS276C, CYS291A, CYS313A, CYS360A, CYS362A, CYS50A, CYS94A, GLN129A, GLN135A, GLN179C, GLN226A, GLN227A, GLN249A, GLN261A, GLN271C, GLN277A, GLN277C, GLN279A, GLN279C, GLN398A, GLN421A, GLN437A, GLN437C, GLU133A, GLU178C, GLU220C, GLU229A, GLU236A, GLU243A, GLU255A, GLU314A, GLU354A, GLU358A, GLU363A, GLU374A, GLU374C, GLU397C, GLU402A, GLU412C, GLU417A, GLU417C, GLU420A, GLU451A, GLU451C, GLU80C, GLY177C, GLY213C, GLY214C, GLY216C, GLY218C, GLY235A, GLY245A, GLY263A, GLY265A, GLY269A, GLY269C, GLY372A, GLY372C, GLY401A, GLY429C, GLY432A, GLY432C, GLY435A, GLY435C, GLY436A, GLY436C, GLY439A, GLY439C, GLY443A, GLY443C, GLY53A, HIS74A, ILE209C, ILE225A, ILE246A, ILE259A, ILE282A, ILE306A, ILE380C, ILE400A, ILE400C, ILE404A, ILE404C, ILE419A, ILE419C, ILE434A, ILE442A, ILE442C, ILE446A, ILE446C, LEU231A, LEU258A, LEU262A, LEU281A, LEU349A, LEU352A, LEU375A, LEU375C, LEU389C, LEU405A, LEU405C, LEU414C, LEU42A, LEU431C, LEU440A, LEU440C, LEU447A, LEU447C, LEU450A, LEU450C, LEU452C, LEU49A, LEU55A, LEU57A, LEU60A, LEU78A, LEU78C, LEU86C, LEU96A, LYS212C, LYS247A, LYS355A, LYS373A, LYS373C, LYS379C, LYS383C, LYS387C, LYS391C, LYS392C, LYS395A, LYS43A, LYS43C, LYS77A, LYS77C, MET211C, MET222C, MET364A, MET377A, MET377C, MET438A, MET438C, MET52A, PHE101A, PHE174C, PHE175C, PHE242A, PHE264A, PHE270A, PHE270C, PHE273C, PHE351A, PHE410C, PHE411C, PHE441A, PHE441C, PHE453C, PHE51A, PRO126A, PRO232A, PRO268A, PRO365A, PRO381C, PRO73A, SER172C, SER241A, SER275A, SER275C, SER376A, SER376C, SER382C, SER385C, SER396A, SER445A, SER445C, SER54A, SER54C, THR128A, THR130A, THR210C, THR215C, THR240A, THR272A, THR272C, THR307A, THR369A, THR418A, THR418C, THR448A, THR448C, THR76A, THR76C, THR84C, TRP234A, TRP47A, TRP47C, TYR192A, TYR230A, TYR283A, TYR359A, TYR371A, TYR388C, TYR393C, TYR399A, TYR416C, TYR455C, TYR457C, VAL233A, VAL248A, VAL266A, VAL274A, VAL353A, VAL361A, VAL368A, VAL378C, VAL406C, VAL449C, VAL45A, VAL46A, VAL61A, VAL75A, VAL75C, VAL81C
• A-E: ALA333A, ARG167E, ARG207E, ARG325A, ASN147A, ASN154A, ASN323A, ASN394E, ASP184E, ASP203E, ASP332A, CYS173E, CYS180E, CYS322A, CYS324A, CYS336A, GLN179E, GLN202E, GLN340A, GLU157A, GLU178E, GLU183E, GLY204E, GLY331A, HIS111A, ILE166E, LEU156A, LEU170E, LEU171E, LEU208E, LYS149A, LYS151A, LYS205E, LYS391E, LYS392E, PHE148A, PHE153A, PRO150A, PRO152A, PRO182E, PRO206E, PRO334A, SER172E, SER181E, THR337A, TYR335A, TYR388E, TYR393E
• A-F: ARG122A, ARG122F, ARG146A, ASN120F, ASN121A, ASN121F, ASN147A, ASN323A, ASN357F, ASP127F, ASP356F, GLN340A, GLU236F, GLU320A, GLU339A, GLU358F, LYS149A, LYS355F, PHE351F, THR128F
• B-C: ALA117C, ALA131C, ALA244C, ALA267B, ALA267C, ALA384B, ALA386B, ALA413B, ALA424C, ALA428B, ALA444B, ALA444C, ALA82B, ALA83B, ARG176B, ARG191C, ARG310C, ARG370B, ARG370C, ARG44C, ARG65C, ARG85B, ASN217B, ASN357C, ASN403C, ASN415B, ASN64C, ASN97C, ASP127C, ASP132C, ASP228C, ASP260C, ASP290C, ASP350C, ASP356C, ASP408B, ASP433B, ASP454B, ASP79B, ASP79C, CYS276B, CYS276C, CYS291C, CYS313C, CYS360C, CYS362C, CYS50C, CYS94C, GLN129C, GLN135C, GLN179B, GLN226C, GLN227C, GLN249C, GLN261C, GLN271B, GLN277B, GLN277C, GLN279B, GLN279C, GLN398C, GLN421C, GLN437B, GLN437C, GLU133C, GLU178B, GLU220B, GLU229C, GLU236C, GLU243C, GLU255C, GLU314C, GLU354C, GLU358C, GLU363C, GLU374B, GLU374C, GLU397B, GLU402C, GLU412B, GLU417B, GLU417C, GLU420C, GLU451B, GLU451C, GLU80B, GLY177B, GLY213B, GLY214B, GLY216B, GLY218B, GLY235C, GLY245C, GLY263C, GLY265C, GLY269B, GLY269C, GLY372B, GLY372C, GLY401C, GLY429B, GLY432B, GLY435B, GLY436B, GLY439B, GLY443B, GLY443C, GLY53C, HIS74C, ILE209B, ILE225C, ILE246C, ILE259C, ILE282C, ILE306C, ILE380B, ILE400B, ILE404B, ILE419B, ILE419C, ILE434B, ILE442B, ILE446B, LEU231C, LEU258C, LEU262C, LEU281C, LEU284C, LEU349C, LEU352C, LEU375B, LEU375C, LEU389B, LEU405B, LEU405C, LEU40C, LEU414B, LEU42C, LEU430B, LEU431B, LEU440B, LEU440C, LEU447B, LEU447C, LEU450B, LEU452B, LEU49C, LEU57C, LEU58B, LEU60C, LEU78B, LEU78C, LEU86B, LEU96C, LYS212B, LYS247C, LYS355C, LYS373B, LYS373C, LYS379B, LYS379C, LYS383B, LYS387B, LYS391B, LYS392B, LYS43C, LYS77B, LYS77C, MET211B, MET222B, MET364C, MET377B, MET377C, MET438B, PHE101C, PHE174B, PHE175B, PHE242C, PHE264C, PHE270B, PHE270C, PHE273B, PHE351C, PHE410B, PHE411B, PHE441B, PHE441C, PHE453B, PHE51B, PHE51C, PRO232C, PRO268C, PRO365C, PRO381B, PRO73C, SER172B, SER241C, SER275B, SER376B, SER376C, SER382B, SER385B, SER396C, SER41C, SER445B, SER445C, SER54B, SER54C, THR128C, THR130C, THR210B, THR215B, THR237C, THR240C, THR272B, THR272C, THR307C, THR369C, THR418B, THR418C, THR448B, THR448C, THR76B, THR76C, THR84B, TRP234C, TRP47B, TRP47C, TYR192C, TYR230C, TYR283C, TYR359C, TYR371C, TYR388B, TYR393B, TYR399C, TYR416B, TYR425B, TYR455B, TYR68C, VAL233C, VAL248C, VAL266C, VAL274C, VAL353C, VAL361C, VAL368C, VAL378B, VAL406B, VAL449B, VAL45C, VAL46C, VAL61B, VAL61C, VAL75B, VAL75C, VAL81B
• D-E: ALA117E, ALA131E, ALA244E, ALA267D, ALA267E, ALA384D, ALA386D, ALA390D, ALA413D, ALA424E, ALA428D, ALA444D, ALA56E, ALA59E, ALA82D, ALA83D, ARG176D, ARG191E, ARG310E, ARG370D, ARG370E, ARG65D, ARG65E, ARG85D, ASN217D, ASN357E, ASN403E, ASN415D, ASN64E, ASN97E, ASP127E, ASP132E, ASP228E, ASP260E, ASP290E, ASP350E, ASP356E, ASP408D, ASP433D, ASP433E, ASP79D, ASP79E, CYS276D, CYS276E, CYS291E, CYS313E, CYS360E, CYS362E, CYS50E, CYS62E, GLN129E, GLN135E, GLN179D, GLN226E, GLN227E, GLN249E, GLN261E, GLN271D, GLN277D, GLN277E, GLN279D, GLN279E, GLN398E, GLN421E, GLN437D, GLN437E, GLU133E, GLU178D, GLU220D, GLU229E, GLU236E, GLU243E, GLU255E, GLU314E, GLU354E, GLU358E, GLU363E, GLU374D, GLU374E, GLU397D, GLU402E, GLU412D, GLU417D, GLU417E, GLU420E, GLU80D, GLY177D, GLY213D, GLY214D, GLY216D, GLY218D, GLY235E, GLY245E, GLY263E, GLY265E, GLY269D, GLY269E, GLY372D, GLY372E, GLY401E, GLY429D, GLY432D, GLY435D, GLY436D, GLY436E, GLY439D, GLY443D, GLY53E, HIS74E, ILE209D, ILE225E, ILE246E, ILE259E, ILE282E, ILE306E, ILE380D, ILE400D, ILE404D, ILE419D, ILE419E, ILE434D, ILE442D, ILE446D, LEU136E, LEU231E, LEU258E, LEU262E, LEU281E, LEU349E, LEU352E, LEU375D, LEU375E, LEU389D, LEU405D, LEU405E, LEU414D, LEU430D, LEU431D, LEU440D, LEU440E, LEU447D, LEU450D, LEU49E, LEU55E, LEU57E, LEU58D, LEU58E, LEU60E, LEU78D, LEU78E, LEU96E, LYS134E, LYS212D, LYS247E, LYS355E, LYS373D, LYS373E, LYS379D, LYS379E, LYS383D, LYS387D, LYS391D, LYS392D, LYS77D, LYS77E, MET211D, MET222D, MET364E, MET377D, MET377E, MET438D, PHE101E, PHE174D, PHE175D, PHE242E, PHE264E, PHE270D, PHE270E, PHE273D, PHE351E, PHE410D, PHE411D, PHE441D, PHE51E, PRO232E, PRO268E, PRO365E, PRO381D, PRO73E, SER172D, SER241E, SER275D, SER376D, SER376E, SER382D, SER385D, SER445D, SER54E, THR128E, THR130E, THR210D, THR215D, THR237E, THR240E, THR272D, THR272E, THR307E, THR369E, THR418D, THR418E, THR76D, THR76E, THR84D, TRP234E, TRP47E, TYR192E, TYR230E, TYR283E, TYR359E, TYR371E, TYR388D, TYR393D, TYR399E, TYR416D, TYR425D, TYR68E, VAL233E, VAL248E, VAL266E, VAL274E, VAL353E, VAL361E, VAL368E, VAL378D, VAL406D, VAL46E, VAL61E, VAL75D, VAL75E, VAL81D
• D-F: ALA117D, ALA131D, ALA244D, ALA267D, ALA267F, ALA384F, ALA386F, ALA413F, ALA424D, ALA428F, ALA444D, ALA444F, ALA48D, ALA56D, ALA82F, ALA83F, ARG176F, ARG191D, ARG280D, ARG310D, ARG370D, ARG44D, ARG65D, ARG85F, ASN217F, ASN357D, ASN367D, ASN403D, ASN415F, ASN64D, ASN97D, ASP127D, ASP132D, ASP228D, ASP260D, ASP290D, ASP350D, ASP356D, ASP408F, ASP433D, ASP433F, ASP79D, ASP79F, CYS276D, CYS276F, CYS291D, CYS313D, CYS360D, CYS362D, CYS50D, CYS94D, GLN129D, GLN135D, GLN179F, GLN226D, GLN227D, GLN249D, GLN261D, GLN271F, GLN277D, GLN277F, GLN279D, GLN279F, GLN398D, GLN421D, GLN437D, GLN437F, GLU133D, GLU178F, GLU220F, GLU229D, GLU236D, GLU243D, GLU255D, GLU314D, GLU354D, GLU358D, GLU363D, GLU374D, GLU374F, GLU397F, GLU402D, GLU412F, GLU417D, GLU417F, GLU420D, GLU451D, GLU451F, GLU80F, GLY177F, GLY213F, GLY214F, GLY216F, GLY218F, GLY235D, GLY245D, GLY263D, GLY265D, GLY269D, GLY269F, GLY372D, GLY372F, GLY401D, GLY429F, GLY432F, GLY435D, GLY435F, GLY436D, GLY436F, GLY439D, GLY439F, GLY443D, GLY443F, GLY53D, HIS74D, ILE209F, ILE225D, ILE246D, ILE259D, ILE282D, ILE306D, ILE380F, ILE400F, ILE404F, ILE419D, ILE419F, ILE434D, ILE442D, ILE442F, ILE446D, ILE446F, LEU118D, LEU136D, LEU231D, LEU258D, LEU262D, LEU281D, LEU284D, LEU349D, LEU352D, LEU375D, LEU375F, LEU389F, LEU405D, LEU405F, LEU414F, LEU431F, LEU440D, LEU440F, LEU447D, LEU447F, LEU450D, LEU450F, LEU452F, LEU49D, LEU55D, LEU57D, LEU58D, LEU58F, LEU60D, LEU78D, LEU78F, LEU86F, LEU96D, LYS212F, LYS247D, LYS355D, LYS373D, LYS373F, LYS379D, LYS379F, LYS383F, LYS387F, LYS391F, LYS392F, LYS43D, LYS77D, LYS77F, MET211F, MET222F, MET364D, MET377D, MET377F, MET438D, MET438F, MET52D, PHE101D, PHE174F, PHE175F, PHE242D, PHE264D, PHE270D, PHE270F, PHE273F, PHE351D, PHE410F, PHE411F, PHE441D, PHE441F, PHE453F, PHE51D, PRO232D, PRO268D, PRO365D, PRO381F, PRO73D, SER172F, SER241D, SER275D, SER275F, SER376D, SER376F, SER382F, SER385F, SER396D, SER445D, SER445F, SER54D, SER54F, THR128D, THR130D, THR210F, THR215F, THR240D, THR272D, THR272F, THR307D, THR369D, THR418D, THR418F, THR448D, THR448F, THR76D, THR76F, THR84F, TRP234D, TRP47D, TRP47F, TYR192D, TYR230D, TYR283D, TYR359D, TYR371D, TYR388F, TYR393F, TYR399D, TYR416F, TYR68D, VAL233D, VAL248D, VAL266D, VAL274D, VAL353D, VAL361D, VAL368D, VAL378F, VAL406F, VAL449D, VAL449F, VAL46D, VAL61D, VAL75D, VAL75F, VAL81F
• E-F: ALA117F, ALA131F, ALA244F, ALA267F, ALA384E, ALA386E, ALA390E, ALA413E, ALA424F, ALA428E, ALA444E, ALA444F, ALA48F, ALA56F, ALA59F, ALA82E, ALA83E, ARG176E, ARG191F, ARG310F, ARG370F, ARG44F, ARG65E, ARG65F, ARG85E, ASN217E, ASN357F, ASN367F, ASN403F, ASN415E, ASN64F, ASN97F, ASP127F, ASP132F, ASP228F, ASP260F, ASP290F, ASP350F, ASP356F, ASP408E, ASP433E, ASP454E, ASP79E, ASP79F, CYS276E, CYS276F, CYS291F, CYS313F, CYS360F, CYS362F, CYS50F, CYS94F, GLN129F, GLN135F, GLN179E, GLN227F, GLN249F, GLN261F, GLN271E, GLN277E, GLN277F, GLN279E, GLN279F, GLN398F, GLN421F, GLN437E, GLN437F, GLU133F, GLU178E, GLU220E, GLU229F, GLU236F, GLU243F, GLU255F, GLU314F, GLU354F, GLU358F, GLU363F, GLU374E, GLU374F, GLU397E, GLU402F, GLU412E, GLU417E, GLU417F, GLU420F, GLU451E, GLU451F, GLU80E, GLY177E, GLY213E, GLY214E, GLY216E, GLY218E, GLY235F, GLY245F, GLY263F, GLY265F, GLY269E, GLY269F, GLY372E, GLY372F, GLY401F, GLY429E, GLY432E, GLY435E, GLY436E, GLY436F, GLY439E, GLY443E, GLY443F, GLY53F, HIS74F, ILE209E, ILE225F, ILE246F, ILE259F, ILE282F, ILE306F, ILE380E, ILE400E, ILE404E, ILE419E, ILE419F, ILE434E, ILE442E, ILE446E, LEU118F, LEU136F, LEU231F, LEU258F, LEU262F, LEU281F, LEU349F, LEU352F, LEU375E, LEU375F, LEU389E, LEU405E, LEU405F, LEU414E, LEU42F, LEU430E, LEU431E, LEU440E, LEU440F, LEU447E, LEU447F, LEU450E, LEU49F, LEU55E, LEU55F, LEU57F, LEU58E, LEU58F, LEU60F, LEU78E, LEU78F, LEU86E, LEU96F, LYS212E, LYS247F, LYS355F, LYS373E, LYS373F, LYS379E, LYS383E, LYS387E, LYS391E, LYS392E, LYS43F, LYS77E, LYS77F, MET211E, MET222E, MET364F, MET377E, MET377F, MET438E, MET52F, PHE101F, PHE174E, PHE175E, PHE242F, PHE264F, PHE270E, PHE270F, PHE273E, PHE351F, PHE410E, PHE411E, PHE441E, PHE441F, PHE51E, PHE51F, PRO232F, PRO268F, PRO365F, PRO381E, PRO73F, SER172E, SER241F, SER275E, SER275F, SER376E, SER376F, SER382E, SER385E, SER445E, SER445F, SER54E, SER54F, THR128F, THR130F, THR210E, THR215E, THR237F, THR240F, THR272E, THR272F, THR307F, THR369F, THR418E, THR418F, THR448E, THR448F, THR76E, THR76F, THR84E, TRP234F, TRP47E, TRP47F, TYR192F, TYR230F, TYR283F, TYR359F, TYR371F, TYR388E, TYR393E, TYR399F, TYR416E, TYR425E, TYR68F, VAL233F, VAL248F, VAL266F, VAL274F, VAL353F, VAL361F, VAL368F, VAL378E, VAL406E, VAL45F, VAL46F, VAL61E, VAL61F, VAL75E, VAL75F, VAL81E