2QRV

structure of dnmt3a-dnmt3l c-terminal domain complex

• Total interactions analyzed: 28
• Total true interactions: 7
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 85
  • Norm. En. per Res.: -4.1161
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-48.0858	-101.4896	-184.407	-333.9824	84	27	1	8406	7	47	54
A-D	-16.224	-9.9175	-218.36	-244.5015	96	24	0	8528	7	35	37
B-F	0.0	0.0	-2.8208	-2.8208	13	0	0	360	0	4	2
C-D	-32.7454	-96.9236	-206.584	-336.253	85	25	1	8600	8	49	53
E-F	-55.2746	-96.1458	-198.446	-349.8663	85	17	1	8416	8	47	54
E-H	-26.5031	-102.2908	-226.028	-354.8219	91	22	0	8743	9	35	40
G-H	-28.5128	-63.0149	-205.014	-296.5417	83	29	1	8760	7	48	53

Interface residues

• A-B: ALA298B, ARG229B, ARG254B, ARG265B, ARG271B, ARG300B, ARG684A, ARG725A, ARG732A, ARG738A, ARG763A, ARG767A, ASN291B, ASP223B, ASP226B, ASP294B, ASP296B, ASP682A, ASP736A, ASP743A, ASP764A, GLN262B, GLN268B, GLN688A, GLU233B, GLU293B, GLU303B, GLU721A, GLU729A, GLU741A, GLU770A, GLY275B, GLY718A, GLY724A, GLY742A, HIS264B, HIS735A, ILE765A, LEU260B, LEU266B, LEU267B, LEU290B, LEU295B, LEU302B, LEU719A, LEU726A, LEU733A, LEU769A, LYS230B, LYS273B, LYS292B, LYS689A, LYS717A, LYS740A, PHE261B, PHE263B, PHE301B, PHE727A, PHE728A, PHE730A, PHE768A, PRO255B, PRO256B, PRO272B, PRO274B, SER257B, SER299B, SER685A, SER760A, SER766A, SER771A, THR225B, THR227B, THR687A, TRP258B, TYR259B, TYR269B, TYR720A, TYR731A, VAL224B, VAL228B, VAL297B, VAL683A, VAL686A
• A-D: ARG672A, ARG672D, ARG819A, ARG819D, ARG862A, ARG862D, ARG878A, ARG878D, ARG881A, ARG881D, ASN849A, ASN849D, ASN875A, ASN875D, ASP664A, ASP664D, ASP853A, ASP853D, ASP872A, ASP872D, CYS857A, CYS857D, GLN674A, GLN674D, GLN882A, GLN882D, GLU663A, GLU663D, GLU816A, GLU816D, GLU859A, GLU859D, GLU861A, GLU861D, GLY669A, GLY669D, GLY675A, GLY675D, GLY818A, GLY818D, HIS673A, HIS673D, HIS817A, HIS817D, HIS869A, HIS869D, ILE666A, ILE666D, ILE677A, ILE677D, ILE854A, ILE854D, LEU815A, LEU815D, LEU855A, LEU855D, LEU879A, LEU879D, LYS676A, LYS676D, LYS851A, LYS851D, MET670A, MET670D, MET848A, MET848D, MET860A, MET860D, MET876A, MET876D, SER874A, SER874D, SER877A, SER877D, THR667A, THR667D, THR858A, THR858D, THR871A, THR871D, TRP856A, TRP856D, TYR679A, TYR679D, TYR870A, TYR870D, VAL668A, VAL668D, VAL671A, VAL671D, VAL846A, VAL846D, VAL868A, VAL868D, VAL873A, VAL873D
• B-F: ASN349B, GLN217F, GLN348B, GLN351B, GLU234F, GLY216F, GLY236F, HIS220F, LEU218F, LYS219F, SER352B, SER353B, TRP235F
• C-D: ALA298C, ARG229C, ARG254C, ARG265C, ARG271C, ARG300C, ARG684D, ARG725D, ARG732D, ARG738D, ARG763D, ARG767D, ASN291C, ASP223C, ASP226C, ASP294C, ASP296C, ASP682D, ASP736D, ASP743D, ASP764D, GLN262C, GLN268C, GLN688D, GLU233C, GLU293C, GLU303C, GLU721D, GLU729D, GLU741D, GLU770D, GLY275C, GLY718D, GLY724D, GLY742D, HIS264C, HIS735D, ILE765D, LEU260C, LEU266C, LEU267C, LEU290C, LEU295C, LEU302C, LEU719D, LEU726D, LEU733D, LEU769D, LYS230C, LYS273C, LYS292C, LYS689D, LYS717D, LYS740D, PHE196C, PHE261C, PHE263C, PHE301C, PHE727D, PHE728D, PHE730D, PHE768D, PRO255C, PRO256C, PRO272C, PRO274C, SER257C, SER299C, SER685D, SER760D, SER766D, SER771D, THR225C, THR227C, THR687D, TRP258C, TYR259C, TYR269C, TYR720D, TYR731D, VAL224C, VAL228C, VAL297C, VAL683D, VAL686D
• E-F: ALA298F, ARG229F, ARG254F, ARG265F, ARG271F, ARG300F, ARG684E, ARG725E, ARG732E, ARG738E, ARG763E, ARG767E, ASN291F, ASP223F, ASP226F, ASP294F, ASP296F, ASP682E, ASP736E, ASP743E, ASP764E, GLN262F, GLN268F, GLN688E, GLU233F, GLU293F, GLU303F, GLU721E, GLU729E, GLU741E, GLU770E, GLY275F, GLY718E, GLY724E, GLY742E, HIS264F, HIS690E, HIS735E, ILE765E, LEU260F, LEU266F, LEU267F, LEU290F, LEU295F, LEU302F, LEU719E, LEU726E, LEU733E, LEU769E, LYS230F, LYS273F, LYS292F, LYS689E, LYS717E, LYS740E, PHE261F, PHE263F, PHE301F, PHE727E, PHE728E, PHE730E, PHE768E, PRO255F, PRO256F, PRO272F, PRO274F, SER257F, SER299F, SER685E, SER760E, SER766E, SER771E, THR225F, THR227F, THR687E, TRP258F, TYR259F, TYR269F, TYR720E, TYR731E, VAL224F, VAL228F, VAL297F, VAL683E, VAL686E
• E-H: ARG672E, ARG672H, ARG819E, ARG819H, ARG862E, ARG862H, ARG878E, ARG878H, ARG881E, ARG881H, ASN849E, ASN849H, ASN875E, ASN875H, ASP664E, ASP853E, ASP853H, ASP872E, ASP872H, CYS857E, CYS857H, GLN674E, GLN674H, GLN882E, GLN882H, GLU663E, GLU663H, GLU816E, GLU816H, GLU859E, GLU859H, GLU861E, GLU861H, GLY669E, GLY675E, GLY675H, GLY818E, GLY818H, HIS673E, HIS673H, HIS817E, HIS817H, HIS869E, HIS869H, ILE666E, ILE666H, ILE854E, ILE854H, LEU815E, LEU815H, LEU855E, LEU855H, LEU879E, LEU879H, LYS676E, LYS676H, LYS851E, LYS851H, MET670E, MET670H, MET848E, MET848H, MET860E, MET860H, MET876E, MET876H, SER874E, SER874H, SER877E, SER877H, THR667E, THR667H, THR858E, THR858H, THR871E, THR871H, TRP856E, TRP856H, TYR679E, TYR679H, TYR870E, TYR870H, VAL668E, VAL668H, VAL671E, VAL671H, VAL846H, VAL868E, VAL868H, VAL873E, VAL873H
• G-H: ALA298G, ARG229G, ARG254G, ARG265G, ARG271G, ARG300G, ARG684H, ARG725H, ARG732H, ARG738H, ARG763H, ARG767H, ASN291G, ASP223G, ASP226G, ASP294G, ASP296G, ASP682H, ASP736H, ASP743H, ASP764H, GLN262G, GLN268G, GLN688H, GLU293G, GLU303G, GLU721H, GLU729H, GLU741H, GLU770H, GLY275G, GLY718H, GLY722H, GLY724H, GLY742H, HIS264G, HIS735H, ILE765H, LEU260G, LEU266G, LEU267G, LEU290G, LEU295G, LEU302G, LEU719H, LEU726H, LEU733H, LEU769H, LYS230G, LYS273G, LYS689H, LYS717H, LYS740H, PHE261G, PHE263G, PHE301G, PHE727H, PHE728H, PHE730H, PHE768H, PRO255G, PRO256G, PRO272G, PRO274G, SER257G, SER299G, SER685H, SER760H, SER766H, SER771H, THR225G, THR227G, THR687H, TRP258G, TYR259G, TYR269G, TYR720H, TYR731H, VAL224G, VAL228G, VAL297G, VAL683H, VAL686H