2QQ3

crystal structure of enoyl-coa hydrates subunit i (gk_2039) other form from geobacillus kaustophilus hta426

• Total interactions analyzed: 66
• Total true interactions: 34
• Strongest Interaction:
  • Chains: D-G
  • Int. Res.: 171
  • Norm. En. per Res.: -5.0263
• Hub Node: B(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-E	-104.0677	-87.7096	-655.095	-846.8723	171	24	18	26165	7	43	41
A-F	-23.0063	-31.4238	-169.991	-224.4212	91	8	4	7367	2	39	40
A-I	-64.3241	-43.6053	-118.942	-226.8713	55	9	5	5645	7	14	30
A-J	0.0	0.0	-2.4284	-2.4284	11	0	0	359	0	0	2
A-L	-95.4978	-76.9519	-646.28	-818.7297	168	26	18	25932	6	43	41
B-C	-88.892	-91.805	-638.228	-818.9249	167	17	18	25755	7	42	41
B-D	-22.5264	-32.294	-167.143	-221.9634	91	7	2	7167	2	40	41
B-G	-68.9849	-42.7376	-113.644	-225.3666	57	12	5	5542	8	14	30
B-H	0.0	4.2529	-2.7043	1.5486	10	0	0	373	0	0	2
B-K	-108.4184	-79.9289	-665.486	-853.8333	174	29	18	26530	6	43	40
B-L	0.0	1.0607	-0.48	0.5807	5	0	0	110	0	4	3
C-D	-51.3462	-43.3704	-119.276	-213.9926	57	8	5	5616	7	14	30
C-G	0.0	0.0	-2.8003	-2.8003	11	0	1	394	0	0	2
C-H	-19.1896	-0.9022	-188.91	-209.0018	99	7	2	7975	2	41	44
C-K	-95.3212	-97.4524	-655.441	-848.2146	173	25	18	26348	7	42	41
C-L	-11.6995	6.0113	-49.9732	-55.6614	48	9	0	2983	2	33	36
D-E	0.0	-1.2674	-23.5861	-24.8535	27	2	0	1451	0	11	10
D-G	-112.8239	-82.0562	-664.62	-859.5001	171	24	18	26508	7	43	41
D-H	-97.9367	-85.5374	-599.099	-782.5731	165	26	13	24499	7	39	38
D-K	0.0	0.0	-2.2543	-2.2543	12	0	0	353	0	0	3
E-F	-73.9048	-44.2953	-118.388	-236.5882	57	10	5	5684	8	14	30
E-H	0.0	-7.341	-51.7826	-59.1236	39	1	1	2299	1	14	15
E-I	0.0	0.0	-2.562	-2.562	12	0	1	383	0	0	3
E-J	-23.4081	-35.1226	-167.174	-225.7047	94	8	4	7157	2	40	42
E-L	-98.1327	-89.2131	-654.657	-842.0028	173	24	18	26354	6	42	41
F-I	-98.0694	-103.1759	-664.838	-866.0833	174	25	18	26839	7	42	41
F-J	-115.1425	-87.1939	-646.998	-849.3344	174	26	18	26253	6	42	40
F-L	0.0	0.0	-1.9952	-1.9952	10	0	0	336	0	0	2
G-H	-99.7535	-75.8172	-634.242	-809.8126	170	25	18	25521	6	42	41
G-K	-21.4713	-32.8104	-162.4	-216.6817	92	3	2	6932	2	37	36
H-K	-57.8628	-43.0304	-116.441	-217.3342	59	7	5	5543	8	14	30
I-J	-84.4554	-75.0903	-646.27	-805.8157	172	19	18	25836	6	42	41
I-L	-21.25	-32.454	-154.297	-208.001	91	9	2	6729	2	38	41
J-L	-69.9481	-42.9481	-115.535	-228.4312	58	9	5	5721	8	14	30

Interface residues

• A-E: ALA100E, ALA114E, ALA141A, ALA156A, ALA164A, ALA171E, ALA194E, ALA204E, ALA211E, ALA215E, ALA236E, ALA245E, ALA246E, ALA28A, ALA64A, ALA66A, ALA72A, ALA86A, ARG146A, ARG146E, ARG155A, ARG155E, ARG179E, ARG196E, ARG206E, ARG228E, ARG31A, ARG78A, ARG90A, ASN134A, ASN178E, ASN230E, ASN83A, ASP118E, ASP217A, ASP217E, ASP239E, ASP67A, ASP74A, ASP75A, ASP87A, ASP89A, CYS117E, GLN145A, GLN173A, GLN173E, GLN200E, GLN213A, GLN213E, GLN225E, GLN240E, GLN69A, GLN84A, GLU112A, GLU112E, GLU132A, GLU158A, GLU172E, GLU210E, GLU222E, GLU227E, GLU238E, GLU242E, GLU249E, GLU70A, GLU80A, GLY136A, GLY140A, GLY142A, GLY143A, GLY152A, GLY163A, GLY175E, GLY223E, GLY243E, GLY65A, ILE120E, ILE151A, ILE151E, ILE176E, ILE208E, ILE53E, ILE68A, ILE77A, ILE93A, ILE99E, LEU107A, LEU113E, LEU115A, LEU115E, LEU119E, LEU135A, LEU147A, LEU150A, LEU150E, LEU157A, LEU160A, LEU174A, LEU174E, LEU193E, LEU197E, LEU203E, LEU205E, LEU207E, LEU220A, LEU220E, LEU233E, LEU234E, LEU248E, LEU26A, LEU79A, LEU82A, LEU91A, LYS149A, LYS149E, LYS154A, LYS209E, LYS214A, LYS214E, LYS229E, LYS241E, LYS73A, LYS95E, MET138A, MET224E, MET244E, MET71A, MET98E, PHE111E, PHE130A, PHE226E, PHE231E, PHE235E, PHE247E, PHE255E, PHE85A, PRO131A, PRO139A, PRO153A, PRO153E, PRO201E, PRO202E, PRO219A, PRO219E, PRO253E, PRO76A, PRO97E, SER116A, SER116E, SER237E, SER92A, THR144A, THR148A, THR162A, THR96E, TRP159A, TRP161A, TRP81A, TRP88A, TYR218A, TYR218E, TYR221E, TYR232E, VAL121E, VAL133A, VAL137A, VAL177E, VAL212E, VAL216A, VAL216E, VAL52E
• A-F: ALA204A, ALA204F, ALA236A, ALA236F, ALA86A, ALA86F, ARG206A, ARG206F, ARG46A, ARG46F, ARG51A, ARG51F, ARG78A, ARG78F, ARG90A, ARG90F, ASN230A, ASN230F, ASN83A, ASN83F, ASP239A, ASP239F, ASP45A, ASP45F, ASP75A, ASP75F, ASP89A, ASP89F, GLN240A, GLN240F, GLN256A, GLU210A, GLU210F, GLU238A, GLU238F, GLU42A, GLU42F, GLU48A, GLU48F, GLU80A, GLU80F, GLY257A, GLY257F, ILE77A, ILE77F, ILE93A, ILE93F, LEU203A, LEU203F, LEU205A, LEU205F, LEU207A, LEU207F, LEU233A, LEU233F, LEU234A, LEU234F, LEU79A, LEU79F, LEU82A, LEU82F, LYS229F, LYS258A, LYS258F, LYS95A, LYS95F, MET138A, PHE226A, PHE226F, PHE235A, PHE235F, PRO201A, PRO201F, PRO202A, PRO202F, PRO76A, PRO76F, PRO97A, PRO97F, SER237A, SER237F, THR96A, THR96F, TRP81A, TRP81F, TYR232A, TYR232F, VAL50A, VAL50F, VAL94A, VAL94F
• A-I: ALA211A, ALA211I, ALA236A, ALA236I, ARG206A, ARG206I, ARG228A, ARG228I, ASN230A, ASN230I, ASP217A, ASP217I, GLN213A, GLN213I, GLN225A, GLN225I, GLU210A, GLU210I, GLU222A, GLU222I, GLU227A, GLU227I, GLY223A, GLY223I, ILE93A, ILE93I, LEU203A, LEU207A, LEU207I, LEU233A, LEU233I, LEU234A, LEU234I, LYS214A, LYS214I, LYS229A, LYS229I, LYS95A, LYS95I, MET224A, MET224I, PHE226A, PHE226I, PHE231A, PHE231I, PHE235A, PHE235I, PRO219A, PRO219I, TYR218A, TYR218I, TYR221A, TYR221I, TYR232A, TYR232I
• A-J: ASP75J, GLU222A, GLU222J, ILE77A, ILE77J, PRO219A, PRO219J, PRO76A, PRO76J, TYR221A, TYR221J
• A-L: ALA100A, ALA114A, ALA141L, ALA156L, ALA164L, ALA171A, ALA204A, ALA211A, ALA215A, ALA236A, ALA245A, ALA246A, ALA66L, ALA72L, ALA86L, ARG146A, ARG146L, ARG155A, ARG155L, ARG165L, ARG179A, ARG196A, ARG206A, ARG228A, ARG31L, ARG78L, ARG90L, ASN134L, ASN178A, ASN230A, ASN83L, ASP118A, ASP217A, ASP217L, ASP239A, ASP67L, ASP74L, ASP75L, ASP87L, ASP89L, CYS117A, GLN145L, GLN173A, GLN200A, GLN213A, GLN213L, GLN225A, GLN240A, GLN69L, GLN84L, GLU112A, GLU112L, GLU132L, GLU158L, GLU170A, GLU172A, GLU199A, GLU210A, GLU222A, GLU227A, GLU238A, GLU242A, GLU249A, GLU70L, GLU80L, GLY136L, GLY140L, GLY142L, GLY143L, GLY152L, GLY163L, GLY175A, GLY223A, GLY243A, GLY65L, ILE120A, ILE151A, ILE151L, ILE176A, ILE208A, ILE53A, ILE68L, ILE77L, ILE93L, ILE99A, LEU113A, LEU115A, LEU115L, LEU119A, LEU135L, LEU147L, LEU150A, LEU150L, LEU157L, LEU160L, LEU174A, LEU174L, LEU193A, LEU197A, LEU203A, LEU205A, LEU207A, LEU220A, LEU220L, LEU233A, LEU234A, LEU248A, LEU79L, LEU82L, LEU91L, LYS149A, LYS149L, LYS154L, LYS209A, LYS214A, LYS214L, LYS229A, LYS241A, LYS73L, LYS95A, MET138L, MET224A, MET244A, MET71L, MET98A, PHE111A, PHE130L, PHE226A, PHE231A, PHE235A, PHE247A, PHE255A, PHE85L, PRO131L, PRO139L, PRO153A, PRO153L, PRO201A, PRO202A, PRO219A, PRO219L, PRO253A, PRO76L, PRO97A, SER116A, SER116L, SER237A, SER92L, THR144L, THR148L, THR162L, THR96A, TRP159L, TRP161L, TRP81L, TRP88L, TYR218A, TYR218L, TYR221A, TYR232A, VAL121A, VAL133L, VAL137L, VAL177A, VAL212A, VAL216A, VAL216L, VAL52A
• B-C: ALA100C, ALA114C, ALA141B, ALA156B, ALA164B, ALA171C, ALA204C, ALA211C, ALA215C, ALA236C, ALA245C, ALA246C, ALA64B, ALA66B, ALA72B, ALA86B, ARG146B, ARG146C, ARG155B, ARG155C, ARG179C, ARG196C, ARG206C, ARG228C, ARG31B, ARG78B, ARG90B, ASN134B, ASN178C, ASN230C, ASN83B, ASP118C, ASP217B, ASP217C, ASP239C, ASP67B, ASP74B, ASP75B, ASP87B, ASP89B, CYS117C, GLN145B, GLN173C, GLN200C, GLN213B, GLN213C, GLN225C, GLN240C, GLN69B, GLN84B, GLU112B, GLU132B, GLU158B, GLU172C, GLU199C, GLU210C, GLU222C, GLU227C, GLU238C, GLU242C, GLU249C, GLU70B, GLU80B, GLY136B, GLY140B, GLY142B, GLY143B, GLY152B, GLY163B, GLY175C, GLY223C, GLY243C, GLY65B, ILE120C, ILE151B, ILE151C, ILE176C, ILE208C, ILE53C, ILE68B, ILE77B, ILE93B, ILE99C, LEU107B, LEU113C, LEU115B, LEU115C, LEU119C, LEU135B, LEU147B, LEU150B, LEU150C, LEU157B, LEU160B, LEU174B, LEU174C, LEU193C, LEU197C, LEU203C, LEU205C, LEU207C, LEU220B, LEU220C, LEU233C, LEU234C, LEU248C, LEU79B, LEU82B, LEU91B, LYS149B, LYS149C, LYS154B, LYS209C, LYS214B, LYS214C, LYS229C, LYS241C, LYS73B, LYS95C, MET138B, MET224C, MET244C, MET71B, MET98C, PHE111C, PHE130B, PHE226C, PHE231C, PHE235C, PHE247C, PHE255C, PHE85B, PRO131B, PRO139B, PRO153B, PRO153C, PRO201C, PRO202C, PRO219B, PRO219C, PRO253C, PRO76B, PRO97C, SER116B, SER116C, SER237C, SER92B, THR144B, THR148B, THR162B, THR96C, TRP159B, TRP161B, TRP81B, TRP88B, TYR218B, TYR218C, TYR221C, TYR232C, VAL121C, VAL133B, VAL137B, VAL177C, VAL212C, VAL216B, VAL216C, VAL52C
• B-D: ALA204B, ALA204D, ALA236B, ALA236D, ALA86B, ALA86D, ARG206B, ARG206D, ARG46B, ARG46D, ARG51B, ARG51D, ARG78B, ARG78D, ARG90B, ARG90D, ASN230B, ASN230D, ASN83B, ASN83D, ASP239B, ASP239D, ASP45B, ASP45D, ASP75B, ASP75D, ASP89B, ASP89D, GLN240B, GLN240D, GLN256B, GLN256D, GLU210B, GLU210D, GLU238B, GLU238D, GLU42B, GLU42D, GLU48B, GLU48D, GLU80B, GLU80D, GLY257B, GLY257D, ILE77B, ILE77D, ILE93B, ILE93D, LEU203B, LEU203D, LEU205B, LEU205D, LEU207B, LEU207D, LEU233B, LEU233D, LEU234B, LEU234D, LEU79B, LEU79D, LEU82B, LEU82D, LYS241D, LYS258B, LYS258D, LYS95B, LYS95D, PHE226B, PHE226D, PHE235B, PHE235D, PRO201B, PRO201D, PRO202B, PRO202D, PRO76B, PRO76D, PRO97B, PRO97D, SER237B, SER237D, THR96B, THR96D, TRP81B, TRP81D, TYR232B, TYR232D, VAL50B, VAL50D, VAL94B, VAL94D
• B-G: ALA211B, ALA211G, ALA236B, ALA236G, ARG206B, ARG206G, ARG228B, ARG228G, ASN230B, ASN230G, ASP217B, ASP217G, ASP89B, GLN213B, GLN213G, GLN225B, GLN225G, GLU210B, GLU210G, GLU222B, GLU222G, GLU227B, GLU227G, GLY223B, GLY223G, ILE93B, ILE93G, LEU203B, LEU203G, LEU207B, LEU207G, LEU233B, LEU233G, LEU234B, LEU234G, LYS214B, LYS214G, LYS229B, LYS229G, LYS95B, LYS95G, MET224B, MET224G, PHE226B, PHE226G, PHE231B, PHE231G, PHE235B, PHE235G, PRO219B, PRO219G, TYR218B, TYR218G, TYR221B, TYR221G, TYR232B, TYR232G
• B-H: GLU222B, GLU222H, ILE77B, ILE77H, PRO219B, PRO219H, PRO76B, PRO76H, TYR221B, TYR221H
• B-K: ALA100B, ALA114B, ALA141K, ALA156K, ALA164K, ALA171B, ALA194B, ALA204B, ALA211B, ALA215B, ALA236B, ALA245B, ALA246B, ALA28K, ALA64K, ALA66K, ALA72K, ALA86K, ARG146B, ARG146K, ARG155B, ARG155K, ARG165K, ARG179B, ARG196B, ARG206B, ARG228B, ARG31K, ARG78K, ARG90K, ASN134K, ASN178B, ASN230B, ASN83K, ASP118B, ASP217B, ASP217K, ASP239B, ASP67K, ASP74K, ASP75K, ASP87K, ASP89K, CYS117B, GLN145K, GLN173B, GLN173K, GLN200B, GLN213B, GLN213K, GLN225B, GLN240B, GLN69K, GLN84K, GLU112B, GLU112K, GLU132K, GLU158K, GLU170B, GLU170K, GLU172B, GLU199B, GLU210B, GLU222B, GLU227B, GLU238B, GLU242B, GLU249B, GLU70K, GLU80K, GLY136K, GLY140K, GLY142K, GLY143K, GLY152K, GLY163K, GLY175B, GLY223B, GLY243B, GLY65K, ILE120B, ILE151B, ILE151K, ILE176B, ILE208B, ILE53B, ILE68K, ILE77K, ILE93K, ILE99B, LEU107K, LEU113B, LEU115B, LEU115K, LEU119B, LEU135K, LEU147K, LEU150B, LEU150K, LEU157K, LEU160K, LEU174B, LEU174K, LEU193B, LEU197B, LEU203B, LEU205B, LEU207B, LEU220B, LEU220K, LEU233B, LEU234B, LEU248B, LEU79K, LEU82K, LEU91K, LYS149B, LYS149K, LYS154K, LYS209B, LYS214B, LYS214K, LYS229B, LYS241B, LYS73K, LYS95B, MET138K, MET224B, MET244B, MET71K, MET98B, PHE111B, PHE130K, PHE226B, PHE231B, PHE235B, PHE247B, PHE255B, PHE85K, PRO131K, PRO139K, PRO153B, PRO153K, PRO201B, PRO202B, PRO219B, PRO219K, PRO253B, PRO76K, PRO97B, SER116B, SER116K, SER237B, SER92K, THR144K, THR148K, THR162K, THR96B, TRP159K, TRP161K, TRP81K, TRP88K, TYR218B, TYR218K, TYR221B, TYR232B, VAL121B, VAL133K, VAL137K, VAL177B, VAL212B, VAL216B, VAL216K, VAL52B
• B-L: ARG251L, ASP75B, GLU249L, LYS250L, LYS73B
• C-D: ALA211C, ALA211D, ALA236C, ALA236D, ARG206C, ARG206D, ARG228C, ARG228D, ASN230C, ASN230D, ASP217C, ASP217D, ASP89C, GLN213D, GLN225C, GLN225D, GLU210C, GLU210D, GLU222C, GLU222D, GLU227C, GLU227D, GLY223C, GLY223D, ILE93C, ILE93D, LEU203C, LEU203D, LEU207C, LEU207D, LEU233C, LEU233D, LEU234C, LEU234D, LYS214C, LYS214D, LYS229C, LYS229D, LYS95C, LYS95D, MET224C, MET224D, PHE226C, PHE226D, PHE231C, PHE231D, PHE235C, PHE235D, PRO219C, PRO219D, SER92C, TYR218C, TYR218D, TYR221C, TYR221D, TYR232C, TYR232D
• C-G: ASP75G, GLU222C, GLU222G, ILE77C, ILE77G, PRO219C, PRO219G, PRO76C, PRO76G, TYR221C, TYR221G
• C-H: ALA204C, ALA204H, ALA236C, ALA236H, ALA86C, ALA86H, ARG206C, ARG206H, ARG46C, ARG46H, ARG51C, ARG51H, ARG78C, ARG78H, ARG90C, ARG90H, ASN230C, ASN230H, ASN47C, ASN47H, ASN83C, ASN83H, ASP239C, ASP239H, ASP45C, ASP45H, ASP75C, ASP75H, ASP87H, ASP89C, ASP89H, GLN240C, GLN240H, GLN256C, GLN256H, GLN84C, GLN84H, GLU210C, GLU210H, GLU238C, GLU238H, GLU42C, GLU42H, GLU48C, GLU48H, GLU80C, GLU80H, GLY257C, GLY257H, ILE77C, ILE77H, ILE93C, ILE93H, LEU203C, LEU203H, LEU205C, LEU205H, LEU207C, LEU207H, LEU233C, LEU233H, LEU234C, LEU234H, LEU79C, LEU79H, LEU82C, LEU82H, LYS229C, LYS241H, LYS258C, LYS258H, LYS95C, LYS95H, MET138H, PHE226C, PHE226H, PHE235C, PHE235H, PRO201C, PRO201H, PRO202C, PRO202H, PRO76C, PRO76H, PRO97C, PRO97H, SER237C, SER237H, THR96C, THR96H, TRP81C, TRP81H, TYR232C, TYR232H, VAL38H, VAL50C, VAL50H, VAL94C, VAL94H
• C-K: ALA100K, ALA114K, ALA141C, ALA156C, ALA164C, ALA171K, ALA194K, ALA204K, ALA211K, ALA215K, ALA236K, ALA245K, ALA246K, ALA28C, ALA64C, ALA66C, ALA72C, ALA86C, ARG146C, ARG146K, ARG155C, ARG155K, ARG165C, ARG179K, ARG196K, ARG206K, ARG228K, ARG31C, ARG78C, ARG90C, ASN134C, ASN178K, ASN230K, ASN83C, ASP118K, ASP217C, ASP217K, ASP239K, ASP67C, ASP74C, ASP75C, ASP87C, ASP89C, CYS117K, GLN145C, GLN173K, GLN200K, GLN213C, GLN213K, GLN225K, GLN240K, GLN69C, GLN84C, GLU112C, GLU132C, GLU158C, GLU172K, GLU199K, GLU210K, GLU222K, GLU227K, GLU238K, GLU242K, GLU249K, GLU70C, GLU80C, GLY136C, GLY140C, GLY142C, GLY143C, GLY152C, GLY163C, GLY175K, GLY223K, GLY243K, GLY65C, ILE120K, ILE151C, ILE151K, ILE176K, ILE208K, ILE53K, ILE68C, ILE77C, ILE93C, ILE99K, LEU107C, LEU113K, LEU115C, LEU115K, LEU119K, LEU135C, LEU147C, LEU150C, LEU150K, LEU157C, LEU160C, LEU174C, LEU174K, LEU193K, LEU197K, LEU203K, LEU205K, LEU207K, LEU220C, LEU220K, LEU233K, LEU234K, LEU248K, LEU26C, LEU79C, LEU82C, LEU91C, LYS149C, LYS149K, LYS154C, LYS154K, LYS209K, LYS214C, LYS214K, LYS229K, LYS241K, LYS252K, LYS73C, LYS95K, MET138C, MET224K, MET244K, MET71C, MET98K, PHE111K, PHE130C, PHE226K, PHE231K, PHE235K, PHE247K, PHE255K, PHE85C, PRO131C, PRO139C, PRO153C, PRO153K, PRO201K, PRO202K, PRO219C, PRO219K, PRO253K, PRO76C, PRO97K, SER116C, SER116K, SER237K, SER92C, THR144C, THR148C, THR162C, THR96K, TRP159C, TRP161C, TRP81C, TRP88C, TYR218C, TYR218K, TYR221K, TYR232K, VAL121K, VAL133C, VAL137C, VAL177K, VAL212K, VAL216C, VAL216K, VAL52K
• C-L: ALA14C, ALA245C, ALA246C, ALA9C, ARG10C, ARG179L, ARG192L, ARG196L, ARG251C, ARG251L, ARG254C, ARG254L, ASN47C, ASP239C, GLN11C, GLN200L, GLN256C, GLU12C, GLU184L, GLU188L, GLU189L, GLU199L, GLU238C, GLU242C, GLU249C, GLY13C, GLY16C, GLY243C, GLY257C, LEU185L, LEU193L, LYS241C, LYS250L, LYS252C, LYS252L, LYS258C, LYS49C, MET191L, PHE255C, PHE44C, PRO183L, PRO253C, PRO253L, SER182L, SER2C, VAL15C, VAL181L, VAL50C
• D-E: ALA125E, ALA245D, ARG251D, ARG58E, ARG60E, ASN103E, GLN240D, GLU184E, GLU188E, GLU238D, GLU242D, GLU249D, GLY57E, GLY59E, LEU185E, LEU186E, LEU248D, LEU26E, LYS241D, LYS250D, MET187E, MET244D, PHE247D, PRO183E, PRO23E, SER123E, SER182E
• D-G: ALA100G, ALA114G, ALA141D, ALA156D, ALA164D, ALA171G, ALA204G, ALA211G, ALA215G, ALA236G, ALA245G, ALA246G, ALA28D, ALA64D, ALA66D, ALA72D, ALA86D, ARG146D, ARG146G, ARG155D, ARG155G, ARG165D, ARG179G, ARG196G, ARG206G, ARG228G, ARG31D, ARG78D, ARG90D, ASN134D, ASN178G, ASN230G, ASN83D, ASP118G, ASP217D, ASP217G, ASP239G, ASP67D, ASP74D, ASP75D, ASP87D, ASP89D, CYS117G, GLN145D, GLN173G, GLN200G, GLN213D, GLN213G, GLN225G, GLN240G, GLN69D, GLN84D, GLU112D, GLU112G, GLU132D, GLU158D, GLU172G, GLU199G, GLU210G, GLU222G, GLU227G, GLU238G, GLU242G, GLU249G, GLU70D, GLU80D, GLY136D, GLY140D, GLY142D, GLY143D, GLY152D, GLY163D, GLY175G, GLY223G, GLY243G, GLY65D, ILE120G, ILE151D, ILE151G, ILE176G, ILE208G, ILE53G, ILE68D, ILE77D, ILE93D, ILE99G, LEU107D, LEU113G, LEU115D, LEU115G, LEU119G, LEU135D, LEU147D, LEU150D, LEU150G, LEU157D, LEU160D, LEU174D, LEU174G, LEU193G, LEU197G, LEU203G, LEU205G, LEU207G, LEU220D, LEU220G, LEU233G, LEU234G, LEU248G, LEU26D, LEU79D, LEU82D, LEU91D, LYS149D, LYS149G, LYS154D, LYS209G, LYS214D, LYS214G, LYS229G, LYS241G, LYS73D, LYS95G, MET138D, MET224G, MET244G, MET71D, MET98G, PHE111G, PHE130D, PHE226G, PHE231G, PHE235G, PHE247G, PHE255G, PHE85D, PRO131D, PRO139D, PRO153D, PRO153G, PRO201G, PRO202G, PRO219D, PRO219G, PRO253G, PRO76D, PRO97G, SER116D, SER116G, SER237G, SER92D, THR144D, THR148D, THR162D, THR96G, TRP159D, TRP161D, TRP81D, TRP88D, TYR218D, TYR218G, TYR221G, TYR232G, VAL121G, VAL133D, VAL137D, VAL177G, VAL212G, VAL216D, VAL216G, VAL52G
• D-H: ALA100D, ALA114D, ALA141H, ALA156H, ALA164H, ALA171D, ALA204D, ALA211D, ALA215D, ALA236D, ALA245D, ALA246D, ALA66H, ALA72H, ALA86H, ARG146D, ARG146H, ARG155D, ARG155H, ARG165H, ARG179D, ARG196D, ARG206D, ARG228D, ARG31H, ARG78H, ARG90H, ASN134H, ASN178D, ASN230D, ASN83H, ASP118D, ASP217D, ASP217H, ASP239D, ASP74H, ASP75H, ASP87H, ASP89H, CYS117D, GLN145H, GLN173D, GLN173H, GLN200D, GLN213D, GLN213H, GLN225D, GLN240D, GLN69H, GLN84H, GLU112D, GLU112H, GLU132H, GLU158H, GLU172D, GLU199D, GLU210D, GLU222D, GLU227D, GLU238D, GLU242D, GLU70H, GLU80H, GLY136H, GLY140H, GLY142H, GLY143H, GLY152H, GLY163H, GLY175D, GLY223D, GLY243D, ILE120D, ILE151D, ILE151H, ILE176D, ILE208D, ILE53D, ILE68H, ILE77H, ILE93H, ILE99D, LEU113D, LEU115D, LEU115H, LEU119D, LEU135H, LEU147H, LEU150D, LEU150H, LEU157H, LEU160H, LEU174D, LEU174H, LEU193D, LEU197D, LEU203D, LEU205D, LEU207D, LEU220D, LEU220H, LEU233D, LEU234D, LEU248D, LEU79H, LEU82H, LEU91H, LYS149D, LYS149H, LYS154H, LYS209D, LYS214D, LYS214H, LYS229D, LYS241D, LYS73H, LYS95D, MET138H, MET224D, MET244D, MET71H, MET98D, PHE111D, PHE130H, PHE226D, PHE231D, PHE235D, PHE247D, PHE255D, PHE85H, PRO131H, PRO139H, PRO153D, PRO153H, PRO201D, PRO202D, PRO219D, PRO219H, PRO253D, PRO76H, PRO97D, SER116D, SER116H, SER237D, SER92H, THR144H, THR148H, THR162H, THR96D, TRP159H, TRP161H, TRP81H, TRP88H, TYR218D, TYR218H, TYR221D, TYR232D, VAL121D, VAL133H, VAL137H, VAL177D, VAL212D, VAL216D, VAL216H, VAL52D
• D-K: ASP75D, ASP75K, GLU222D, GLU222K, ILE77D, ILE77K, PRO219D, PRO219K, PRO76D, PRO76K, TYR221D, TYR221K
• E-F: ALA211E, ALA211F, ALA236E, ALA236F, ARG206E, ARG206F, ARG228E, ARG228F, ASN230E, ASN230F, ASP217E, ASP217F, ASP89F, GLN213E, GLN213F, GLN225E, GLN225F, GLU210E, GLU210F, GLU222E, GLU222F, GLU227E, GLU227F, GLY223E, GLY223F, ILE93E, ILE93F, LEU203E, LEU203F, LEU207E, LEU207F, LEU233E, LEU233F, LEU234E, LEU234F, LYS214E, LYS214F, LYS229E, LYS229F, LYS95E, LYS95F, MET224E, MET224F, PHE226E, PHE226F, PHE231E, PHE231F, PHE235E, PHE235F, PRO219E, PRO219F, TYR218E, TYR218F, TYR221E, TYR221F, TYR232E, TYR232F
• E-H: ALA125E, ALA126E, ALA168E, ALA28H, ALA72H, ARG165E, ARG22H, ARG60E, ARG78H, ASN103E, ASP24H, ASP67H, ASP74H, ASP75H, GLN32H, GLN69H, GLU127E, GLU170E, GLU184E, GLU70H, GLY104E, ILE68H, LEU105E, LEU185E, LEU26H, LYS169E, LYS73H, MET166E, MET71H, PHE128E, PRO183E, SER123E, SER124E, SER167E, SER182E, VAL180E, VAL181E, VAL25H, VAL5H
• E-I: ASP75E, ASP75I, GLU222E, GLU222I, ILE77E, ILE77I, PRO219E, PRO219I, PRO76E, PRO76I, TYR221E, TYR221I
• E-J: ALA204E, ALA204J, ALA236E, ALA236J, ALA86E, ALA86J, ARG206E, ARG206J, ARG46E, ARG46J, ARG51E, ARG51J, ARG78E, ARG78J, ARG90E, ARG90J, ASN230E, ASN230J, ASN83E, ASN83J, ASP239E, ASP239J, ASP45E, ASP45J, ASP75E, ASP75J, ASP87J, ASP89E, ASP89J, GLN240E, GLN240J, GLN256E, GLN256J, GLN84E, GLU210E, GLU210J, GLU238E, GLU238J, GLU42E, GLU42J, GLU48E, GLU48J, GLU80E, GLU80J, GLY257E, GLY257J, ILE77E, ILE77J, ILE93E, ILE93J, LEU203E, LEU203J, LEU205E, LEU205J, LEU207E, LEU207J, LEU233E, LEU233J, LEU234E, LEU234J, LEU79E, LEU79J, LEU82E, LEU82J, LYS229E, LYS258E, LYS258J, LYS95E, LYS95J, MET138J, PHE226E, PHE226J, PHE235E, PHE235J, PRO201E, PRO201J, PRO202E, PRO202J, PRO76E, PRO76J, PRO97E, PRO97J, SER237E, SER237J, THR96E, THR96J, TRP81E, TRP81J, TYR232E, TYR232J, VAL50E, VAL50J, VAL94E, VAL94J
• E-L: ALA100L, ALA114L, ALA141E, ALA156E, ALA164E, ALA171L, ALA204L, ALA211L, ALA215L, ALA236L, ALA245L, ALA246L, ALA28E, ALA64E, ALA66E, ALA72E, ALA86E, ARG146E, ARG146L, ARG155E, ARG155L, ARG165E, ARG179L, ARG192L, ARG196L, ARG206L, ARG228L, ARG31E, ARG78E, ARG90E, ASN134E, ASN178L, ASN230L, ASN83E, ASP118L, ASP217E, ASP217L, ASP239L, ASP67E, ASP74E, ASP75E, ASP87E, ASP89E, CYS117L, GLN145E, GLN173L, GLN200L, GLN213E, GLN213L, GLN225L, GLN240L, GLN69E, GLN84E, GLU112E, GLU112L, GLU132E, GLU158E, GLU170E, GLU170L, GLU172L, GLU210L, GLU222L, GLU227L, GLU238L, GLU242L, GLU249L, GLU70E, GLU80E, GLY136E, GLY140E, GLY142E, GLY143E, GLY152E, GLY163E, GLY175L, GLY223L, GLY243L, GLY65E, ILE120L, ILE151E, ILE151L, ILE176L, ILE208L, ILE53L, ILE68E, ILE77E, ILE93E, ILE99L, LEU107E, LEU113L, LEU115E, LEU115L, LEU119L, LEU135E, LEU147E, LEU150E, LEU150L, LEU157E, LEU160E, LEU174E, LEU174L, LEU193L, LEU197L, LEU203L, LEU205L, LEU207L, LEU220E, LEU220L, LEU233L, LEU234L, LEU248L, LEU26E, LEU79E, LEU82E, LEU91E, LYS149E, LYS149L, LYS154E, LYS209L, LYS214E, LYS214L, LYS229L, LYS241L, LYS73E, LYS95L, MET138E, MET224L, MET244L, MET71E, MET98L, PHE111L, PHE130E, PHE226L, PHE231L, PHE235L, PHE247L, PHE255L, PHE85E, PRO131E, PRO139E, PRO153E, PRO153L, PRO201L, PRO202L, PRO219E, PRO219L, PRO253L, PRO76E, PRO97L, SER116E, SER116L, SER237L, SER92E, THR144E, THR148E, THR162E, THR96L, TRP159E, TRP161E, TRP81E, TRP88E, TYR218E, TYR218L, TYR221L, TYR232L, VAL121L, VAL133E, VAL137E, VAL177L, VAL212L, VAL216E, VAL216L, VAL52L
• F-I: ALA100I, ALA114I, ALA141F, ALA156F, ALA164F, ALA171I, ALA204I, ALA211I, ALA215I, ALA236I, ALA245I, ALA246I, ALA28F, ALA64F, ALA66F, ALA72F, ALA86F, ARG146F, ARG146I, ARG155F, ARG155I, ARG165F, ARG179I, ARG196I, ARG206I, ARG228I, ARG31F, ARG78F, ARG90F, ASN134F, ASN178I, ASN230I, ASN83F, ASP118I, ASP217F, ASP217I, ASP239I, ASP67F, ASP74F, ASP75F, ASP87F, ASP89F, CYS117I, GLN145F, GLN173F, GLN173I, GLN200I, GLN213F, GLN213I, GLN225I, GLN240I, GLN69F, GLN84F, GLU112F, GLU112I, GLU132F, GLU158F, GLU170F, GLU172I, GLU199I, GLU210I, GLU222I, GLU227I, GLU238I, GLU242I, GLU249I, GLU70F, GLU80F, GLY136F, GLY140F, GLY142F, GLY143F, GLY152F, GLY163F, GLY175I, GLY223I, GLY243I, GLY65F, ILE120I, ILE151F, ILE151I, ILE176I, ILE208I, ILE53I, ILE68F, ILE77F, ILE93F, ILE99I, LEU107F, LEU113I, LEU115F, LEU115I, LEU119I, LEU135F, LEU147F, LEU150F, LEU150I, LEU157F, LEU160F, LEU174F, LEU174I, LEU193I, LEU197I, LEU203I, LEU205I, LEU207I, LEU220F, LEU220I, LEU233I, LEU234I, LEU248I, LEU26F, LEU79F, LEU82F, LEU91F, LYS149F, LYS149I, LYS154F, LYS209I, LYS214F, LYS214I, LYS229I, LYS241I, LYS250I, LYS73F, LYS95I, MET138F, MET224I, MET244I, MET71F, MET98I, PHE111I, PHE130F, PHE226I, PHE231I, PHE235I, PHE247I, PHE255I, PHE85F, PRO131F, PRO139F, PRO153F, PRO153I, PRO201I, PRO202I, PRO219F, PRO219I, PRO253I, PRO76F, PRO97I, SER116F, SER116I, SER237I, SER92F, THR144F, THR148F, THR162F, THR96I, TRP159F, TRP161F, TRP81F, TRP88F, TYR218F, TYR218I, TYR221I, TYR232I, VAL121I, VAL133F, VAL137F, VAL177I, VAL212I, VAL216F, VAL216I, VAL52I
• F-J: ALA100F, ALA114F, ALA141J, ALA156J, ALA164J, ALA171F, ALA194F, ALA204F, ALA211F, ALA215F, ALA236F, ALA245F, ALA246F, ALA28J, ALA64J, ALA66J, ALA72J, ALA86J, ARG146F, ARG146J, ARG155F, ARG155J, ARG165J, ARG179F, ARG196F, ARG206F, ARG228F, ARG31J, ARG78J, ARG90J, ASN134J, ASN178F, ASN230F, ASN83J, ASP118F, ASP217F, ASP217J, ASP239F, ASP67J, ASP74J, ASP75J, ASP87J, ASP89J, CYS117F, GLN145J, GLN173F, GLN200F, GLN213F, GLN213J, GLN225F, GLN240F, GLN69J, GLN84J, GLU112F, GLU112J, GLU132J, GLU158J, GLU172F, GLU199F, GLU210F, GLU222F, GLU227F, GLU238F, GLU242F, GLU249F, GLU70J, GLU80J, GLY136J, GLY140J, GLY142J, GLY143J, GLY152J, GLY163J, GLY175F, GLY223F, GLY243F, GLY65J, ILE120F, ILE151F, ILE151J, ILE176F, ILE208F, ILE53F, ILE68J, ILE77J, ILE93J, ILE99F, LEU107J, LEU113F, LEU115F, LEU115J, LEU119F, LEU135J, LEU147J, LEU150F, LEU150J, LEU157J, LEU160J, LEU174F, LEU174J, LEU193F, LEU197F, LEU203F, LEU205F, LEU207F, LEU220F, LEU220J, LEU233F, LEU234F, LEU248F, LEU26J, LEU79J, LEU82J, LEU91J, LYS149F, LYS149J, LYS154J, LYS209F, LYS214F, LYS214J, LYS229F, LYS241F, LYS250F, LYS252F, LYS73J, LYS95F, MET138J, MET224F, MET244F, MET71J, MET98F, PHE111F, PHE130J, PHE226F, PHE231F, PHE235F, PHE247F, PHE255F, PHE85J, PRO131J, PRO139J, PRO153F, PRO153J, PRO201F, PRO202F, PRO219F, PRO219J, PRO253F, PRO76J, PRO97F, SER116F, SER116J, SER237F, SER92J, THR144J, THR148J, THR162J, THR96F, TRP159J, TRP161J, TRP81J, TRP88J, TYR218F, TYR218J, TYR221F, TYR232F, VAL121F, VAL133J, VAL137J, VAL177F, VAL212F, VAL216F, VAL216J, VAL52F
• F-L: GLU222F, GLU222L, ILE77F, ILE77L, PRO219F, PRO219L, PRO76F, PRO76L, TYR221F, TYR221L
• G-H: ALA100H, ALA114H, ALA141G, ALA156G, ALA164G, ALA171H, ALA204H, ALA211H, ALA215H, ALA236H, ALA245H, ALA246H, ALA28G, ALA64G, ALA66G, ALA72G, ALA86G, ARG146G, ARG146H, ARG155G, ARG155H, ARG165G, ARG179H, ARG196H, ARG206H, ARG228H, ARG31G, ARG78G, ARG90G, ASN134G, ASN178H, ASN230H, ASN83G, ASP118H, ASP217G, ASP217H, ASP239H, ASP67G, ASP74G, ASP75G, ASP87G, ASP89G, CYS117H, GLN145G, GLN173H, GLN200H, GLN213G, GLN213H, GLN225H, GLN240H, GLN69G, GLN84G, GLU112G, GLU112H, GLU132G, GLU158G, GLU172H, GLU199H, GLU210H, GLU222H, GLU227H, GLU238H, GLU242H, GLU249H, GLU70G, GLU80G, GLY136G, GLY140G, GLY142G, GLY143G, GLY152G, GLY163G, GLY175H, GLY223H, GLY243H, GLY65G, ILE120H, ILE151G, ILE151H, ILE176H, ILE208H, ILE53H, ILE68G, ILE77G, ILE93G, ILE99H, LEU107G, LEU113H, LEU115G, LEU115H, LEU119H, LEU135G, LEU147G, LEU150G, LEU150H, LEU157G, LEU160G, LEU174G, LEU174H, LEU193H, LEU197H, LEU203H, LEU205H, LEU207H, LEU220G, LEU220H, LEU233H, LEU234H, LEU248H, LEU79G, LEU82G, LEU91G, LYS149G, LYS149H, LYS154G, LYS209H, LYS214G, LYS214H, LYS229H, LYS241H, LYS73G, LYS95H, MET138G, MET224H, MET244H, MET71G, MET98H, PHE111H, PHE130G, PHE226H, PHE231H, PHE235H, PHE247H, PHE255H, PHE85G, PRO131G, PRO139G, PRO153G, PRO153H, PRO201H, PRO202H, PRO219G, PRO219H, PRO253H, PRO76G, PRO97H, SER116G, SER116H, SER237H, SER92G, THR144G, THR148G, THR162G, THR96H, TRP159G, TRP161G, TRP81G, TRP88G, TYR218G, TYR218H, TYR221H, TYR232H, VAL121H, VAL133G, VAL137G, VAL177H, VAL212H, VAL216G, VAL216H, VAL52H
• G-K: ALA204G, ALA204K, ALA236G, ALA236K, ALA86G, ALA86K, ARG206G, ARG206K, ARG46G, ARG46K, ARG51G, ARG51K, ARG78G, ARG78K, ARG90G, ARG90K, ASN230G, ASN230K, ASN47K, ASN83G, ASN83K, ASP239G, ASP239K, ASP45G, ASP45K, ASP75G, ASP75K, ASP89G, ASP89K, GLN240G, GLN240K, GLN256G, GLU210G, GLU210K, GLU238G, GLU238K, GLU42G, GLU42K, GLU48G, GLU48K, GLU80G, GLU80K, GLY257G, GLY257K, ILE77G, ILE77K, ILE93G, ILE93K, LEU203G, LEU203K, LEU205G, LEU205K, LEU207G, LEU207K, LEU233G, LEU233K, LEU234G, LEU234K, LEU79G, LEU79K, LEU82G, LEU82K, LYS229K, LYS258G, LYS258K, LYS95G, LYS95K, MET138G, PHE226G, PHE226K, PHE235G, PHE235K, PRO201G, PRO201K, PRO202G, PRO202K, PRO76G, PRO76K, PRO97G, PRO97K, SER237G, SER237K, THR96G, THR96K, TRP81G, TRP81K, TYR232G, TYR232K, VAL50G, VAL50K, VAL94G, VAL94K
• H-K: ALA211H, ALA211K, ALA236H, ALA236K, ARG206H, ARG206K, ARG228H, ARG228K, ARG90K, ASN230H, ASN230K, ASP217H, ASP217K, ASP89K, GLN213H, GLN213K, GLN225H, GLN225K, GLU210H, GLU210K, GLU222H, GLU222K, GLU227H, GLU227K, GLY223H, GLY223K, ILE93H, ILE93K, LEU203H, LEU203K, LEU207H, LEU207K, LEU233H, LEU233K, LEU234H, LEU234K, LYS214H, LYS214K, LYS229H, LYS229K, LYS95H, LYS95K, MET224H, MET224K, PHE226H, PHE226K, PHE231H, PHE231K, PHE235H, PHE235K, PRO219H, PRO219K, SER92K, TYR218H, TYR218K, TYR221H, TYR221K, TYR232H, TYR232K
• I-J: ALA100J, ALA114J, ALA141I, ALA156I, ALA164I, ALA171J, ALA194J, ALA204J, ALA211J, ALA215J, ALA236J, ALA245J, ALA246J, ALA28I, ALA64I, ALA66I, ALA72I, ALA86I, ARG146I, ARG146J, ARG155I, ARG155J, ARG179J, ARG196J, ARG206J, ARG228J, ARG31I, ARG78I, ARG90I, ASN134I, ASN178J, ASN230J, ASN83I, ASP118J, ASP217I, ASP217J, ASP239J, ASP67I, ASP74I, ASP75I, ASP87I, ASP89I, CYS117J, GLN145I, GLN173I, GLN173J, GLN200J, GLN213I, GLN213J, GLN225J, GLN240J, GLN69I, GLN84I, GLU112I, GLU112J, GLU132I, GLU158I, GLU172J, GLU199J, GLU210J, GLU222J, GLU227J, GLU238J, GLU242J, GLU249J, GLU70I, GLU80I, GLY136I, GLY140I, GLY142I, GLY143I, GLY152I, GLY163I, GLY175J, GLY223J, GLY243J, GLY65I, ILE120J, ILE151I, ILE151J, ILE176J, ILE208J, ILE53J, ILE68I, ILE77I, ILE93I, ILE99J, LEU107I, LEU113J, LEU115I, LEU115J, LEU119J, LEU135I, LEU147I, LEU150I, LEU150J, LEU157I, LEU160I, LEU174I, LEU174J, LEU193J, LEU197J, LEU203J, LEU205J, LEU207J, LEU220I, LEU220J, LEU233J, LEU234J, LEU248J, LEU26I, LEU79I, LEU82I, LEU91I, LYS149I, LYS149J, LYS154I, LYS209J, LYS214I, LYS214J, LYS229J, LYS241J, LYS73I, LYS95J, MET138I, MET224J, MET244J, MET71I, MET98J, PHE111J, PHE130I, PHE226J, PHE231J, PHE235J, PHE247J, PHE255J, PHE85I, PRO131I, PRO139I, PRO153I, PRO153J, PRO201J, PRO202J, PRO219I, PRO219J, PRO253J, PRO76I, PRO97J, SER116I, SER116J, SER237J, SER92I, THR144I, THR148I, THR162I, THR96J, TRP159I, TRP161I, TRP81I, TRP88I, TYR218I, TYR218J, TYR221J, TYR232J, VAL121J, VAL133I, VAL137I, VAL177J, VAL212J, VAL216I, VAL216J, VAL52J
• I-L: ALA204I, ALA204L, ALA236I, ALA236L, ALA86I, ALA86L, ARG206I, ARG206L, ARG46I, ARG46L, ARG51I, ARG51L, ARG78I, ARG78L, ARG90I, ARG90L, ASN230I, ASN230L, ASN83I, ASN83L, ASP239I, ASP239L, ASP45I, ASP45L, ASP75I, ASP75L, ASP89I, ASP89L, GLN240I, GLN240L, GLN256I, GLU210I, GLU210L, GLU238I, GLU238L, GLU42I, GLU42L, GLU48I, GLU48L, GLU80I, GLU80L, GLY257I, GLY257L, ILE77I, ILE77L, ILE93I, ILE93L, LEU203I, LEU203L, LEU205I, LEU205L, LEU207I, LEU207L, LEU233I, LEU233L, LEU234I, LEU234L, LEU79I, LEU79L, LEU82I, LEU82L, LYS229I, LYS258I, LYS258L, LYS95I, LYS95L, MET138L, PHE226I, PHE226L, PHE235I, PHE235L, PRO201I, PRO201L, PRO202I, PRO202L, PRO76I, PRO76L, PRO97I, PRO97L, SER237I, SER237L, THR96I, THR96L, TRP81I, TRP81L, TYR232I, TYR232L, VAL50I, VAL50L, VAL94I, VAL94L
• J-L: ALA211J, ALA211L, ALA236J, ALA236L, ARG206J, ARG206L, ARG228J, ARG228L, ASN230J, ASN230L, ASP217J, ASP217L, ASP89J, GLN213J, GLN213L, GLN225J, GLN225L, GLU210J, GLU210L, GLU222J, GLU222L, GLU227J, GLU227L, GLY223J, GLY223L, ILE93J, ILE93L, LEU203J, LEU203L, LEU207J, LEU207L, LEU233J, LEU233L, LEU234J, LEU234L, LYS214J, LYS214L, LYS229J, LYS229L, LYS95J, LYS95L, MET224J, MET224L, PHE226J, PHE226L, PHE231J, PHE231L, PHE235J, PHE235L, PRO219J, PRO219L, SER92J, TYR218J, TYR218L, TYR221J, TYR221L, TYR232J, TYR232L