2QPF

crystal structure of mouse transthyretin

• Total interactions analyzed: 28
• Total true interactions: 10
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 90
  • Norm. En. per Res.: -4.1272
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-99.3187	4.2843	-265.418	-360.4524	88	12	8	9771	0	24	24
A-C	-25.1692	0.0	-72.8201	-97.9893	55	3	2	3548	0	4	6
A-D	-21.1349	0.0	-95.9833	-117.1182	42	4	6	3616	0	0	2
B-C	-21.5313	0.0	-101.446	-122.9773	42	5	6	3687	0	0	2
B-D	-25.5115	0.0	-75.1072	-100.6187	57	3	2	3605	0	4	6
B-E	-10.2737	10.1304	-28.9254	-29.0687	38	1	0	1500	0	10	14
B-G	0.0	7.0701	-1.3723	5.6978	14	0	0	234	0	8	10
C-D	-107.0735	8.4789	-272.851	-371.4456	90	15	8	9865	0	24	23
E-F	-24.269	0.0	-70.4652	-94.7342	53	2	2	3400	0	4	6
G-H	-27.0565	6.5816	-82.1174	-102.5923	57	7	2	3912	0	4	6

Interface residues

• A-B: ALA108A, ALA108B, ALA109A, ALA109B, ALA120A, ALA120B, ALA91A, ALA91B, ALA97A, ALA97B, ARG103A, ARG103B, ARG70A, ARG70B, ASN98A, ASN98B, ASP92A, ASP92B, ASP99A, ASP99B, GLU72A, GLU72B, GLU89A, GLU89B, GLY67A, HIS104A, HIS104B, HIS88A, HIS88B, ILE107A, ILE107B, LEU110A, LEU110B, LEU12A, LEU12B, LYS35A, LYS35B, LYS76A, LYS76B, PHE64A, PHE64B, PHE87A, PHE87B, PHE90A, PHE90B, PHE95A, PHE95B, PRO113A, PRO113B, PRO86A, PRO86B, SER112A, SER112B, SER115A, SER115B, SER117A, SER117B, THR106A, THR106B, THR118A, THR118B, THR119A, THR119B, THR75A, THR96A, THR96B, TRP41A, TRP41B, TYR105A, TYR105B, TYR114A, TYR114B, TYR116A, TYR116B, TYR69A, TYR69B, VAL121A, VAL121B, VAL122A, VAL122B, VAL68A, VAL68B, VAL71A, VAL71B, VAL93A, VAL93B, VAL94A, VAL94B
• A-C: ALA108A, ALA108C, ALA109A, ALA109C, ALA120A, ALA120C, ALA19A, ALA19C, ALA25A, ALA25C, ARG103C, ARG21A, ARG21C, ASP18A, ASP18C, GLU54A, GLU54C, GLY22A, GLY22C, GLY53A, LEU110A, LEU110C, LEU111A, LEU111C, LEU17A, LEU17C, LYS15A, LYS15C, PRO24A, PRO24C, SER112A, SER117A, SER117C, SER123A, SER123C, SER23A, SER23C, SER52A, SER52C, THR106A, THR106C, THR118A, THR118C, THR119A, THR119C, TYR105A, TYR105C, VAL121A, VAL121C, VAL122A, VAL122C, VAL16A, VAL16C, VAL20A, VAL20C
• A-D: ALA19A, ALA19D, ARG21A, ARG21D, ASP18A, ASP18D, GLY22A, GLY22D, HIS88A, HIS88D, ILE84A, ILE84D, LEU110A, LEU110D, LEU111A, LEU111D, LEU17A, LEU17D, PHE87A, PHE87D, PRO113A, PRO113D, PRO86A, PRO86D, SER112A, SER112D, SER115A, SER115D, SER117A, SER117D, SER23A, SER23D, SER85A, SER85D, TRP79A, TRP79D, TYR114A, TYR114D, TYR116A, TYR116D, VAL20A, VAL20D
• B-C: ALA19B, ALA19C, ARG21B, ARG21C, ASP18B, ASP18C, GLY22B, GLY22C, HIS88B, HIS88C, ILE84B, ILE84C, LEU110B, LEU110C, LEU111B, LEU111C, LEU17B, LEU17C, PHE87B, PHE87C, PRO113B, PRO113C, PRO86B, PRO86C, SER112B, SER112C, SER115B, SER115C, SER117B, SER117C, SER23B, SER23C, SER85B, SER85C, TRP79B, TRP79C, TYR114B, TYR114C, TYR116B, TYR116C, VAL20B, VAL20C
• B-D: ALA108B, ALA108D, ALA109B, ALA109D, ALA120B, ALA120D, ALA19B, ALA19D, ALA25B, ALA25D, ARG103D, ARG21B, ARG21D, ASP18B, ASP18D, GLU54B, GLU54D, GLY22B, GLY22D, GLY53B, GLY53D, LEU110B, LEU110D, LEU111B, LEU111D, LEU17B, LEU17D, LYS15B, LYS15D, MET13B, PRO24B, PRO24D, SER112D, SER117B, SER117D, SER123B, SER123D, SER23B, SER23D, SER52B, SER52D, THR106B, THR106D, THR118B, THR118D, THR119B, THR119D, TYR105B, TYR105D, VAL121B, VAL121D, VAL122B, VAL122D, VAL16B, VAL16D, VAL20B, VAL20D
• B-E: ALA29E, ALA45B, ALA50B, ASP27B, ASP27E, ASP74E, GLU51B, GLU54B, GLY47B, GLY57B, GLY83E, HIS56B, ILE84E, LEU55B, LEU58B, LEU82E, LYS31E, LYS48B, LYS48E, LYS63B, LYS80E, LYS9B, MET13B, PRO86E, SER46B, SER52B, SER77E, SER85E, THR49B, THR49E, THR59B, THR60B, THR81E, TRP79E, TYR78E, VAL26B, VAL26E, VAL28E
• B-G: ALA50G, ARG103B, GLU51G, GLU62B, GLY101B, GLY47G, GLY57G, HIS102B, HIS56G, LYS48G, LYS9B, SER52G, THR49G, THR60G
• C-D: ALA108C, ALA108D, ALA109C, ALA109D, ALA120C, ALA120D, ALA91C, ALA91D, ALA97C, ALA97D, ARG103C, ARG103D, ARG70C, ARG70D, ASN98C, ASN98D, ASP92C, ASP92D, ASP99C, ASP99D, GLU72C, GLU72D, GLU89C, GLU89D, GLY67D, HIS104C, HIS104D, HIS88C, HIS88D, ILE107C, ILE107D, LEU110C, LEU110D, LEU12C, LEU12D, LYS35C, LYS35D, LYS76C, LYS76D, PHE64C, PHE64D, PHE87C, PHE87D, PHE90C, PHE90D, PHE95C, PHE95D, PRO113C, PRO113D, PRO86C, PRO86D, SER100C, SER112C, SER112D, SER115C, SER115D, SER117C, SER117D, SER85D, THR106C, THR106D, THR118C, THR118D, THR119C, THR119D, THR75D, THR96C, THR96D, TRP41C, TRP41D, TYR105C, TYR105D, TYR114C, TYR114D, TYR116C, TYR116D, TYR69C, TYR69D, VAL121C, VAL121D, VAL122C, VAL122D, VAL68C, VAL68D, VAL71C, VAL71D, VAL93C, VAL93D, VAL94C, VAL94D
• E-F: ALA108E, ALA108F, ALA109E, ALA109F, ALA120E, ALA120F, ALA19E, ALA19F, ALA25E, ALA25F, ARG21E, ARG21F, ASP18E, ASP18F, GLU54E, GLU54F, GLY22E, GLY22F, GLY53E, LEU110E, LEU110F, LEU111E, LEU111F, LEU17E, LEU17F, LYS15E, LYS15F, PRO24E, PRO24F, SER112E, SER117E, SER117F, SER123E, SER123F, SER23E, SER23F, SER52E, SER52F, THR106E, THR106F, THR118E, THR118F, THR119E, THR119F, TYR105F, VAL121E, VAL121F, VAL122E, VAL122F, VAL16E, VAL16F, VAL20E, VAL20F
• G-H: ALA108G, ALA108H, ALA109G, ALA109H, ALA120G, ALA120H, ALA19G, ALA19H, ALA25G, ALA25H, ARG21G, ARG21H, ASP18G, ASP18H, GLU54G, GLU54H, GLY22G, GLY22H, GLY53G, GLY53H, ILE107G, LEU110G, LEU110H, LEU111G, LEU111H, LEU17G, LEU17H, LYS15G, LYS15H, MET13H, PRO24G, PRO24H, SER112H, SER117G, SER117H, SER123G, SER123H, SER23G, SER23H, SER52G, SER52H, THR106G, THR106H, THR118G, THR118H, THR119G, THR119H, TYR105G, TYR105H, VAL121G, VAL121H, VAL122G, VAL122H, VAL16G, VAL16H, VAL20G, VAL20H