2QMI

structure of the octameric penicillin-binding protein homologue from pyrococcus abyssi

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: B-H
  • Int. Res.: 260
  • Norm. En. per Res.: -3.6813
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-28.9206	0.1326	-230.818	-259.606	90	9	4	9224	0	32	20
A-D	-25.6022	-2.6157	-229.314	-257.5319	87	6	4	9234	0	30	20
A-E	-106.9761	-97.4626	-747.52	-951.9587	275	42	10	29442	5	76	48
A-F	-12.4007	-32.4579	-40.7975	-85.6561	57	3	0	1793	2	25	38
B-C	-27.4883	-3.1269	-224.254	-254.8692	87	10	4	9091	1	30	22
B-E	-14.2392	-39.9954	-45.4719	-99.7065	58	5	0	2091	2	26	39
B-H	-111.6883	-110.9371	-734.504	-957.1293	260	40	10	28560	7	75	49
C-D	-32.0943	-26.2766	-233.96	-292.3309	88	11	4	9377	3	30	21
C-G	-85.3478	-57.4184	-700.355	-843.1212	258	32	10	27988	5	76	47
C-H	-13.721	-30.2998	-34.2256	-78.2464	51	4	0	1597	2	23	36
D-F	-82.802	-45.4019	-685.577	-813.7808	258	25	10	27027	7	76	49
D-G	-12.9568	2.0922	-46.78	-57.6446	63	15	0	2252	3	27	39
E-F	-22.79	-9.7123	-225.525	-258.0274	89	7	3	9077	0	30	21
E-H	-32.2394	-3.8308	-226.469	-262.5392	90	4	3	9254	0	32	23
F-G	-22.898	-8.5383	-229.854	-261.2903	92	9	4	9303	0	32	23
G-H	-27.3128	4.021	-219.582	-242.8739	87	7	3	8944	1	30	22

Interface residues

• A-B: ALA119A, ALA141A, ALA143A, ALA15B, ALA45B, ARG144A, ARG17B, ARG221B, ARG41B, ARG46B, ASN129A, ASN328B, ASN42B, ASN89A, ASP122A, ASP128A, ASP145A, ASP2B, GLN225A, GLU12B, GLU137A, GLU138A, GLU16B, GLU202A, GLU205A, GLU219B, GLU351B, GLU44B, GLU7B, GLY123A, GLY126A, GLY127A, GLY21B, GLY220B, GLY230A, GLY37B, GLY39B, GLY4B, ILE10B, ILE121A, ILE140A, ILE215A, ILE22B, ILE231A, LEU131A, LEU216B, LEU222B, LEU344B, LEU47B, LEU6B, LYS13B, LYS18B, LYS201A, LYS36B, LYS5B, MET124A, MET14B, MET212A, MET308A, PHE120A, PHE142A, PHE227A, PHE38B, PHE9B, PRO132A, PRO136A, PRO20B, PRO224A, PRO226A, PRO228A, PRO48B, SER134A, SER49B, SER8B, THR135A, THR139A, THR50B, TRP130A, TYR214B, TYR229A, TYR309A, TYR340B, TYR34B, TYR40B, VAL11B, VAL125A, VAL133A, VAL19B, VAL3B, VAL43B
• A-D: ALA119D, ALA141D, ALA143D, ALA15A, ALA45A, ARG144D, ARG17A, ARG221A, ARG41A, ARG46A, ASN129D, ASN328A, ASN42A, ASN89D, ASP122D, ASP128D, ASP145D, ASP2A, GLN225D, GLU12A, GLU137D, GLU138D, GLU16A, GLU202D, GLU205D, GLU219A, GLU44A, GLU7A, GLY123D, GLY126D, GLY127D, GLY21A, GLY220A, GLY230D, GLY37A, GLY39A, GLY4A, ILE10A, ILE121D, ILE140D, ILE215D, ILE22A, ILE231D, LEU131D, LEU216A, LEU222A, LEU47A, LEU6A, LYS13A, LYS18A, LYS201D, LYS36A, LYS5A, MET124D, MET14A, MET308D, PHE120D, PHE142D, PHE227D, PHE38A, PHE9A, PRO132D, PRO136D, PRO20A, PRO224D, PRO226D, PRO228D, PRO48A, SER134D, SER49A, SER8A, THR135D, THR139D, THR50A, TRP130D, TYR214A, TYR229D, TYR309D, TYR340A, TYR40A, VAL11A, VAL125D, VAL133D, VAL19A, VAL306D, VAL3A, VAL43A
• A-E: ALA117A, ALA117E, ALA119A, ALA119E, ALA141A, ALA141E, ALA143A, ALA143E, ALA150A, ALA150E, ALA152A, ALA152E, ALA392A, ALA392E, ALA396A, ALA396E, ALA426A, ALA426E, ARG144A, ARG144E, ARG157A, ARG157E, ARG359A, ARG359E, ARG369A, ARG391A, ARG395A, ARG395E, ARG422A, ARG422E, ARG441A, ARG441E, ARG443A, ARG443E, ASN129A, ASN129E, ASN162A, ASN162E, ASN293A, ASN293E, ASN420A, ASN420E, ASP122A, ASP122E, ASP128A, ASP128E, ASP145A, ASP145E, ASP217A, ASP217E, ASP384A, ASP384E, ASP386A, ASP386E, ASP436A, ASP436E, CYS415A, CYS415E, GLN225A, GLN225E, GLU118A, GLU118E, GLU147A, GLU147E, GLU219A, GLU277A, GLU277E, GLU282A, GLU282E, GLU406A, GLU406E, GLU427A, GLU427E, GLU440A, GLU440E, GLY110A, GLY110E, GLY115A, GLY115E, GLY123A, GLY123E, GLY126A, GLY126E, GLY127A, GLY127E, GLY280A, GLY280E, GLY281A, GLY281E, GLY307A, GLY307E, GLY372A, GLY372E, GLY375A, GLY375E, GLY385A, GLY385E, GLY394A, GLY394E, GLY421A, GLY421E, HIS107A, HIS107E, HIS302A, HIS302E, ILE111A, ILE111E, ILE121A, ILE121E, ILE140A, ILE140E, ILE215A, ILE215E, ILE278A, ILE278E, ILE289A, ILE289E, ILE357A, ILE357E, ILE377A, ILE377E, ILE401A, ILE401E, ILE438A, ILE438E, ILE445A, ILE445E, ILE90A, ILE90E, LEU114A, LEU114E, LEU131A, LEU131E, LEU161A, LEU161E, LEU216A, LEU216E, LEU354A, LEU363A, LEU363E, LEU393A, LEU393E, LEU403A, LEU403E, LEU408A, LEU408E, LEU418A, LEU418E, LEU437A, LEU437E, LEU444A, LEU444E, LYS148A, LYS148E, LYS218A, LYS218E, LYS273A, LYS374A, LYS374E, LYS378A, LYS378E, LYS414A, LYS423A, LYS423E, LYS62A, LYS62E, MET124E, MET146A, MET146E, MET308E, MET339A, MET339E, MET371A, MET371E, MET424A, MET424E, PHE120A, PHE120E, PHE142A, PHE142E, PHE158A, PHE158E, PHE159A, PHE159E, PHE279A, PHE279E, PHE356A, PHE356E, PHE379A, PHE379E, PHE397A, PHE397E, PHE404A, PHE404E, PHE412A, PHE439A, PHE439E, PHE95A, PHE95E, PRO112A, PRO112E, PRO275A, PRO275E, PRO333A, PRO333E, PRO355A, PRO355E, PRO402A, PRO402E, PRO405A, PRO405E, SER113A, SER113E, SER303A, SER305A, SER305E, SER330E, SER335A, SER335E, SER419A, SER419E, SER59A, SER59E, THR139A, THR139E, THR163A, THR163E, THR376A, THR376E, THR398A, THR398E, THR400A, THR400E, THR417A, THR417E, TRP130A, TRP130E, TRP149A, TRP149E, TRP276A, TRP276E, TYR116A, TYR116E, TYR160A, TYR160E, TYR291E, TYR336A, TYR336E, TYR358A, TYR373A, TYR373E, TYR389A, TYR389E, TYR399A, TYR399E, TYR416A, TYR416E, TYR425A, TYR425E, TYR429A, TYR429E, TYR442A, TYR442E, VAL125A, VAL125E, VAL151A, VAL151E, VAL223E, VAL274A, VAL274E, VAL387A, VAL387E, VAL388A, VAL388E, VAL407A
• A-F: ALA15A, ALA15F, ALA396A, ARG221A, ARG221F, ARG369F, ARG395A, ARG395F, ASN433A, ASN433F, ASP217A, ASP217F, ASP432A, ASP432F, ASP436F, GLU12A, GLU12F, GLU16A, GLU16F, GLU219A, GLU219F, GLU367F, GLY220A, GLY220F, GLY368A, GLY368F, GLY375A, GLY375F, ILE445F, LYS18F, LYS218A, LYS218F, LYS364A, LYS374A, LYS374F, LYS378A, LYS378F, LYS431A, LYS431F, LYS434A, LYS434F, LYS446A, LYS446F, MET371F, PHE9A, SER447A, SER447F, SER8A, SER8F, THR376A, THR376F, TYR373A, TYR373F, VAL11A, VAL11F, VAL435A, VAL435F
• B-C: ALA119B, ALA141B, ALA143B, ALA15C, ALA45C, ARG144B, ARG17C, ARG221C, ARG41C, ARG46C, ASN129B, ASN328C, ASN42C, ASN89B, ASP122B, ASP128B, ASP145B, ASP2C, GLN225B, GLU12C, GLU137B, GLU138B, GLU16C, GLU202B, GLU205B, GLU219C, GLU44C, GLU7C, GLY123B, GLY126B, GLY127B, GLY21C, GLY220C, GLY230B, GLY37C, GLY39C, GLY4C, ILE10C, ILE121B, ILE140B, ILE215B, ILE22C, ILE231B, LEU131B, LEU216C, LEU222C, LEU47C, LEU6C, LYS13C, LYS18C, LYS201B, LYS36C, LYS5C, MET124B, MET14C, MET212B, MET308B, PHE120B, PHE142B, PHE227B, PHE38C, PHE9C, PRO132B, PRO20C, PRO224B, PRO226B, PRO228B, PRO48C, SER134B, SER49C, SER8C, THR135B, THR139B, THR50C, TRP130B, TYR116B, TYR214C, TYR229B, TYR309B, TYR34C, TYR40C, VAL11C, VAL125B, VAL133B, VAL19C, VAL3C, VAL43C
• B-E: ALA15B, ALA15E, ARG221B, ARG221E, ARG369E, ARG395B, ARG395E, ASN433B, ASN433E, ASP217B, ASP217E, ASP432B, ASP432E, ASP436E, GLU12B, GLU12E, GLU16B, GLU16E, GLU219B, GLU219E, GLU367E, GLY220B, GLY220E, GLY368E, GLY375B, GLY375E, ILE445E, LEU216B, LEU216E, LYS18B, LYS18E, LYS218B, LYS218E, LYS364B, LYS374B, LYS374E, LYS378B, LYS378E, LYS431B, LYS431E, LYS434B, LYS434E, LYS446B, LYS446E, MET371E, PHE9B, PHE9E, SER447B, SER8B, SER8E, THR376B, THR376E, TYR373B, TYR373E, VAL11B, VAL11E, VAL435B, VAL435E
• B-H: ALA117B, ALA117H, ALA119B, ALA119H, ALA141B, ALA141H, ALA143B, ALA143H, ALA150B, ALA150H, ALA152B, ALA152H, ALA392B, ALA392H, ALA396B, ALA396H, ALA426B, ARG144B, ARG144H, ARG157B, ARG157H, ARG359B, ARG359H, ARG395B, ARG395H, ARG422B, ARG422H, ARG441B, ARG441H, ARG443B, ARG443H, ASN129B, ASN129H, ASN162B, ASN162H, ASN293H, ASN420B, ASN420H, ASP122B, ASP122H, ASP128B, ASP128H, ASP145B, ASP145H, ASP217B, ASP217H, ASP384B, ASP384H, ASP386B, ASP386H, ASP436B, ASP436H, CYS415B, CYS415H, GLN225B, GLN225H, GLU118B, GLU118H, GLU147B, GLU147H, GLU219H, GLU277B, GLU277H, GLU282B, GLU282H, GLU406B, GLU406H, GLU427B, GLU427H, GLU440B, GLU440H, GLY110B, GLY110H, GLY115B, GLY115H, GLY123B, GLY123H, GLY126B, GLY126H, GLY127B, GLY127H, GLY280B, GLY280H, GLY281B, GLY281H, GLY372B, GLY372H, GLY375B, GLY375H, GLY385B, GLY385H, GLY394B, GLY394H, GLY421B, GLY421H, HIS107B, HIS107H, HIS302B, HIS302H, ILE111B, ILE111H, ILE121B, ILE121H, ILE140B, ILE140H, ILE215B, ILE215H, ILE278B, ILE278H, ILE377B, ILE377H, ILE401B, ILE401H, ILE438B, ILE438H, ILE445B, ILE445H, ILE90B, ILE90H, LEU114B, LEU114H, LEU131B, LEU131H, LEU161B, LEU161H, LEU216B, LEU216H, LEU363B, LEU363H, LEU393B, LEU393H, LEU403B, LEU403H, LEU408B, LEU408H, LEU418B, LEU418H, LEU437B, LEU437H, LEU444B, LEU444H, LYS148B, LYS148H, LYS218B, LYS218H, LYS273H, LYS374B, LYS374H, LYS378B, LYS378H, LYS414B, LYS423B, LYS423H, LYS446B, LYS62B, LYS62H, MET146B, MET146H, MET371B, MET371H, MET424B, MET424H, PHE120B, PHE120H, PHE142B, PHE142H, PHE158B, PHE158H, PHE159B, PHE159H, PHE279B, PHE279H, PHE356B, PHE356H, PHE379B, PHE379H, PHE397B, PHE397H, PHE404B, PHE404H, PHE412B, PHE439B, PHE439H, PHE95B, PHE95H, PRO112B, PRO112H, PRO275B, PRO275H, PRO333B, PRO355B, PRO355H, PRO402B, PRO402H, PRO405B, PRO405H, SER113B, SER113H, SER303B, SER303H, SER305B, SER305H, SER330H, SER419B, SER419H, SER59B, SER59H, THR139B, THR139H, THR163B, THR163H, THR376B, THR376H, THR398B, THR398H, THR400B, THR400H, THR417B, THR417H, TRP130B, TRP130H, TRP149B, TRP149H, TRP276B, TRP276H, TYR116B, TYR116H, TYR160B, TYR160H, TYR336B, TYR336H, TYR358B, TYR370B, TYR373B, TYR373H, TYR389B, TYR389H, TYR399B, TYR399H, TYR416B, TYR416H, TYR425B, TYR425H, TYR429B, TYR429H, TYR442B, TYR442H, VAL125B, VAL125H, VAL133B, VAL151B, VAL151H, VAL223B, VAL274B, VAL274H, VAL387B, VAL387H, VAL388B, VAL388H, VAL407H
• C-D: ALA119C, ALA141C, ALA143C, ALA15D, ALA45D, ARG144C, ARG17D, ARG221D, ARG41D, ARG46D, ASN129C, ASN328D, ASN42D, ASN89C, ASP122C, ASP128C, ASP145C, ASP2D, GLN225C, GLU12D, GLU137C, GLU138C, GLU16D, GLU202C, GLU219D, GLU44D, GLU7D, GLY123C, GLY126C, GLY127C, GLY21D, GLY220D, GLY230C, GLY37D, GLY39D, GLY4D, ILE10D, ILE121C, ILE140C, ILE215C, ILE22D, ILE231C, LEU131C, LEU216D, LEU222D, LEU344D, LEU47D, LEU6D, LYS13D, LYS18D, LYS201C, LYS218C, LYS36D, LYS5D, MET124C, MET14D, MET308C, PHE120C, PHE142C, PHE227C, PHE38D, PHE9D, PRO132C, PRO20D, PRO224C, PRO226C, PRO228C, PRO48D, SER134C, SER49D, SER8D, THR135C, THR139C, THR50D, TRP130C, TYR116C, TYR214D, TYR229C, TYR309C, TYR340D, TYR34D, TYR40D, VAL11D, VAL125C, VAL133C, VAL19D, VAL3D, VAL43D
• C-G: ALA117C, ALA117G, ALA119C, ALA119G, ALA141C, ALA141G, ALA143C, ALA143G, ALA150C, ALA150G, ALA152C, ALA152G, ALA392G, ALA396C, ALA396G, ALA426C, ALA426G, ARG144C, ARG144G, ARG157C, ARG157G, ARG221C, ARG359C, ARG359G, ARG395C, ARG395G, ARG422C, ARG422G, ARG441C, ARG441G, ARG443C, ARG443G, ASN129C, ASN129G, ASN162C, ASN162G, ASN293C, ASN420C, ASN420G, ASP122C, ASP122G, ASP128C, ASP128G, ASP145C, ASP145G, ASP217C, ASP217G, ASP384C, ASP384G, ASP386C, ASP386G, ASP436C, ASP436G, CYS415C, CYS415G, GLN225C, GLN225G, GLU118C, GLU118G, GLU147C, GLU147G, GLU219C, GLU277C, GLU277G, GLU282C, GLU406C, GLU406G, GLU427C, GLU427G, GLU440C, GLU440G, GLY110C, GLY110G, GLY115C, GLY115G, GLY123C, GLY123G, GLY126C, GLY126G, GLY127C, GLY127G, GLY220C, GLY280C, GLY280G, GLY281C, GLY307G, GLY372C, GLY372G, GLY375C, GLY375G, GLY385C, GLY385G, GLY394C, GLY394G, GLY421C, GLY421G, HIS107C, HIS107G, HIS302C, HIS302G, ILE111C, ILE111G, ILE121C, ILE121G, ILE140C, ILE140G, ILE215C, ILE215G, ILE278C, ILE278G, ILE289C, ILE289G, ILE377C, ILE377G, ILE401C, ILE401G, ILE438C, ILE438G, ILE445C, ILE445G, ILE90C, ILE90G, LEU114C, LEU114G, LEU131C, LEU131G, LEU161C, LEU161G, LEU216C, LEU216G, LEU363C, LEU363G, LEU393C, LEU393G, LEU403C, LEU403G, LEU408G, LEU418C, LEU418G, LEU437C, LEU437G, LEU444C, LEU444G, LYS148C, LYS148G, LYS218C, LYS218G, LYS374C, LYS374G, LYS378C, LYS378G, LYS414G, LYS423C, LYS423G, LYS446C, LYS62C, LYS62G, MET124G, MET146C, MET146G, MET371C, MET371G, MET424C, MET424G, PHE120C, PHE120G, PHE142C, PHE142G, PHE158C, PHE158G, PHE159C, PHE159G, PHE279C, PHE279G, PHE356C, PHE356G, PHE379C, PHE379G, PHE397C, PHE397G, PHE404C, PHE404G, PHE412C, PHE439C, PHE439G, PHE95C, PHE95G, PRO112C, PRO112G, PRO275C, PRO275G, PRO333C, PRO355C, PRO355G, PRO402C, PRO402G, PRO405C, PRO405G, SER113C, SER113G, SER303C, SER305C, SER305G, SER419C, SER419G, SER59C, SER59G, THR139C, THR139G, THR163C, THR163G, THR376C, THR376G, THR398C, THR398G, THR400C, THR400G, THR417C, THR417G, TRP130C, TRP130G, TRP149C, TRP149G, TRP276C, TRP276G, TYR116C, TYR116G, TYR160C, TYR160G, TYR336C, TYR336G, TYR358C, TYR373C, TYR373G, TYR389C, TYR389G, TYR399C, TYR399G, TYR416C, TYR416G, TYR425C, TYR425G, TYR429C, TYR429G, TYR442C, TYR442G, VAL125C, VAL125G, VAL151C, VAL151G, VAL223C, VAL223G, VAL274C, VAL274G, VAL387C, VAL387G, VAL388C, VAL388G
• C-H: ALA15C, ALA15H, ALA396H, ARG221C, ARG221H, ARG395C, ARG395H, ASN433C, ASN433H, ASP217C, ASP432C, ASP432H, GLU12C, GLU12H, GLU16C, GLU16H, GLU219C, GLU219H, GLY220C, GLY220H, GLY375C, GLY375H, ILE445C, LYS18C, LYS218C, LYS218H, LYS364H, LYS374C, LYS374H, LYS378C, LYS378H, LYS431C, LYS431H, LYS434C, LYS434H, LYS446C, LYS446H, MET371C, MET371H, PHE397H, PHE9H, SER447H, SER8C, SER8H, THR376C, THR376H, TYR373C, TYR373H, VAL11C, VAL11H, VAL435H
• D-F: ALA117D, ALA117F, ALA119D, ALA119F, ALA141D, ALA141F, ALA143D, ALA143F, ALA150D, ALA150F, ALA152D, ALA152F, ALA392F, ALA396D, ALA396F, ALA426D, ALA426F, ARG144D, ARG144F, ARG157D, ARG157F, ARG359D, ARG359F, ARG395D, ARG395F, ARG422D, ARG422F, ARG441D, ARG441F, ARG443D, ARG443F, ASN129D, ASN129F, ASN162D, ASN162F, ASN420D, ASN420F, ASP122D, ASP122F, ASP128D, ASP128F, ASP145D, ASP145F, ASP217D, ASP217F, ASP384D, ASP384F, ASP386D, ASP386F, ASP436D, ASP436F, CYS415D, CYS415F, GLN225D, GLN225F, GLU118D, GLU118F, GLU147D, GLU147F, GLU219D, GLU277D, GLU277F, GLU282D, GLU406D, GLU406F, GLU427D, GLU427F, GLU440D, GLU440F, GLY110D, GLY110F, GLY115D, GLY115F, GLY123D, GLY123F, GLY126D, GLY126F, GLY127D, GLY127F, GLY280D, GLY307D, GLY307F, GLY372D, GLY372F, GLY375D, GLY375F, GLY385D, GLY385F, GLY394D, GLY394F, GLY421D, GLY421F, HIS107D, HIS107F, HIS302D, HIS302F, ILE111D, ILE111F, ILE121D, ILE121F, ILE140D, ILE140F, ILE215D, ILE215F, ILE278D, ILE278F, ILE289D, ILE377D, ILE377F, ILE401D, ILE401F, ILE438D, ILE438F, ILE445D, ILE445F, ILE90D, ILE90F, LEU114D, LEU114F, LEU131D, LEU131F, LEU161D, LEU161F, LEU216D, LEU216F, LEU363D, LEU363F, LEU390F, LEU393D, LEU393F, LEU403D, LEU403F, LEU408D, LEU408F, LEU418D, LEU418F, LEU437D, LEU437F, LEU444D, LEU444F, LYS148D, LYS148F, LYS218D, LYS218F, LYS273F, LYS374D, LYS374F, LYS378D, LYS378F, LYS414D, LYS414F, LYS423D, LYS423F, LYS62D, LYS62F, MET124D, MET146D, MET146F, MET308D, MET371D, MET371F, MET424D, MET424F, PHE120D, PHE120F, PHE142D, PHE142F, PHE158D, PHE158F, PHE159D, PHE159F, PHE279D, PHE356D, PHE356F, PHE379D, PHE379F, PHE397D, PHE397F, PHE404D, PHE404F, PHE412D, PHE412F, PHE439D, PHE439F, PHE95D, PHE95F, PRO112D, PRO112F, PRO275D, PRO275F, PRO333F, PRO355D, PRO355F, PRO402D, PRO402F, PRO405D, PRO405F, SER113D, SER113F, SER303D, SER305D, SER305F, SER330D, SER330F, SER419D, SER419F, SER59D, SER59F, THR139D, THR139F, THR163D, THR163F, THR376D, THR376F, THR398F, THR400D, THR400F, THR417D, THR417F, TRP130D, TRP130F, TRP149D, TRP149F, TRP276D, TRP276F, TYR116D, TYR116F, TYR160D, TYR160F, TYR291D, TYR336D, TYR336F, TYR358D, TYR373D, TYR373F, TYR389D, TYR389F, TYR399D, TYR399F, TYR416D, TYR416F, TYR425D, TYR425F, TYR429D, TYR429F, TYR442D, TYR442F, VAL125D, VAL125F, VAL151D, VAL151F, VAL223D, VAL274D, VAL274F, VAL387D, VAL387F, VAL388D, VAL388F
• D-G: ALA15D, ALA15G, ALA396G, ARG221D, ARG221G, ARG369D, ARG369G, ARG395D, ARG395G, ASN433D, ASN433G, ASP217D, ASP217G, ASP432D, ASP432G, GLU12D, GLU12G, GLU16D, GLU16G, GLU219D, GLU219G, GLU367D, GLU367G, GLU380D, GLY220D, GLY220G, GLY368D, GLY368G, GLY375D, GLY375G, GLY394G, ILE445G, LEU216D, LEU222D, LYS18D, LYS18G, LYS218D, LYS218G, LYS364D, LYS364G, LYS374D, LYS374G, LYS378G, LYS382G, LYS431D, LYS431G, LYS434D, LYS434G, LYS446D, LYS446G, MET371G, PHE397G, PHE9D, SER447G, SER8D, SER8G, THR376D, THR376G, TYR373D, TYR373G, VAL11D, VAL11G, VAL435D
• E-F: ALA119E, ALA141E, ALA143E, ALA15F, ALA45F, ARG144E, ARG17F, ARG221F, ARG41F, ARG46F, ASN129E, ASN328F, ASN42F, ASN89E, ASP122E, ASP128E, ASP145E, ASP2F, GLN225E, GLU12F, GLU137E, GLU138E, GLU16F, GLU202E, GLU205E, GLU219F, GLU351F, GLU44F, GLU7F, GLY123E, GLY126E, GLY127E, GLY213E, GLY21F, GLY220F, GLY230E, GLY37F, GLY39F, GLY4F, ILE10F, ILE121E, ILE140E, ILE215E, ILE22F, ILE231E, LEU131E, LEU216F, LEU222F, LEU47F, LEU6F, LYS13F, LYS18F, LYS201E, LYS36F, LYS5F, MET124E, MET14F, MET212E, MET308E, PHE120E, PHE142E, PHE227E, PHE38F, PHE9F, PRO132E, PRO20F, PRO224E, PRO226E, PRO228E, PRO48F, SER134E, SER329F, SER49F, SER8F, THR135E, THR139E, THR50F, TRP130E, TYR214F, TYR229E, TYR309E, TYR340F, TYR40F, VAL11F, VAL125E, VAL133E, VAL19F, VAL3F, VAL43F
• E-H: ALA119H, ALA141H, ALA143H, ALA15E, ALA45E, ARG144H, ARG17E, ARG221E, ARG41E, ARG46E, ASN129H, ASN328E, ASN42E, ASN89H, ASP122H, ASP128H, ASP145H, ASP2E, GLN225H, GLU12E, GLU137H, GLU138H, GLU16E, GLU202H, GLU205H, GLU219E, GLU351E, GLU44E, GLU7E, GLY123H, GLY126H, GLY127H, GLY213H, GLY21E, GLY220E, GLY230H, GLY37E, GLY39E, GLY4E, ILE10E, ILE121H, ILE140H, ILE215H, ILE22E, ILE231H, LEU131H, LEU216E, LEU222E, LEU344E, LEU47E, LEU6E, LYS13E, LYS18E, LYS201H, LYS36E, LYS5E, MET124H, MET14E, MET308H, PHE120H, PHE142H, PHE227H, PHE38E, PHE9E, PRO132H, PRO20E, PRO224H, PRO226H, PRO228H, PRO48E, SER134H, SER329E, SER49E, SER8E, THR135H, THR139H, THR50E, TRP130H, TYR214E, TYR229H, TYR309H, TYR340E, TYR40E, VAL11E, VAL125H, VAL133H, VAL19E, VAL306H, VAL3E, VAL43E
• F-G: ALA119F, ALA141F, ALA143F, ALA15G, ALA45G, ARG144F, ARG17G, ARG221G, ARG41G, ARG46G, ASN129F, ASN328G, ASN42G, ASN89F, ASP122F, ASP128F, ASP145F, ASP2G, GLN225F, GLU12G, GLU137F, GLU138F, GLU16G, GLU202F, GLU205F, GLU219G, GLU351G, GLU44G, GLU7G, GLY123F, GLY126F, GLY127F, GLY213F, GLY21G, GLY220G, GLY230F, GLY37G, GLY39G, GLY4G, ILE10G, ILE121F, ILE140F, ILE215F, ILE22G, ILE231F, LEU131F, LEU216G, LEU222G, LEU344G, LEU47G, LEU6G, LYS13G, LYS18G, LYS201F, LYS218F, LYS36G, LYS5G, MET124F, MET14G, MET212F, MET308F, PHE120F, PHE142F, PHE227F, PHE38G, PHE9G, PRO132F, PRO20G, PRO224F, PRO226F, PRO228F, PRO48G, SER134F, SER49G, SER8G, THR135F, THR139F, THR50G, TRP130F, TYR214G, TYR229F, TYR309F, TYR340G, TYR34G, TYR40G, VAL11G, VAL125F, VAL133F, VAL19G, VAL306F, VAL3G, VAL43G
• G-H: ALA119G, ALA141G, ALA143G, ALA15H, ALA45H, ARG144G, ARG17H, ARG221H, ARG41H, ARG46H, ASN129G, ASN328H, ASN42H, ASN89G, ASP122G, ASP128G, ASP145G, ASP2H, GLN225G, GLU12H, GLU137G, GLU138G, GLU16H, GLU202G, GLU205G, GLU219H, GLU44H, GLU7H, GLY123G, GLY126G, GLY127G, GLY21H, GLY220H, GLY230G, GLY37H, GLY39H, GLY4H, ILE10H, ILE121G, ILE140G, ILE215G, ILE22H, ILE231G, LEU131G, LEU216H, LEU222H, LEU344H, LEU47H, LEU6H, LYS13H, LYS18H, LYS201G, LYS218G, LYS36H, LYS5H, MET124G, MET14H, MET308G, PHE120G, PHE142G, PHE227G, PHE38H, PHE9H, PRO132G, PRO20H, PRO224G, PRO226G, PRO228G, PRO48H, SER134G, SER49H, SER8H, THR135G, THR139G, THR50H, TRP130G, TYR214H, TYR229G, TYR309G, TYR340H, TYR40H, VAL11H, VAL125G, VAL133G, VAL19H, VAL3H, VAL43H