2QMH

structure of v267f mutant hprk/p

• Total interactions analyzed: 66
• Total true interactions: 34
• Strongest Interaction:
  • Chains: E-J
  • Int. Res.: 27
  • Norm. En. per Res.: -3.4322
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	-6.7499	-208.255	-215.0049	95	5	16	9971	0	18	17
A-C	-8.848	-17.8295	-171.336	-198.0135	89	8	17	9182	1	18	18
A-D	-15.5978	33.7207	-183.256	-165.1331	94	6	2	7489	0	18	31
A-E	0.0	0.0	-6.0159	-6.0159	16	0	0	430	0	3	5
A-F	-13.5789	0.0	-40.2835	-53.8624	24	9	2	1842	0	0	1
B-C	-19.2938	-21.9718	-280.739	-322.0046	115	13	20	13100	3	32	30
B-D	-13.8164	0.0	-49.5812	-63.3976	24	0	2	1734	0	0	0
B-E	-9.2827	44.9593	-182.16	-146.4834	91	6	2	7377	0	16	28
B-F	0.0	0.0	-0.0466	-0.0466	3	0	0	13	0	0	0
C-D	0.0	0.0	-0.0623	-0.0623	4	0	0	17	0	0	0
C-E	-11.9326	0.0	-50.2257	-62.1583	24	1	2	1737	0	0	1
C-F	0.0	45.4618	-176.01	-130.5482	90	6	2	7322	0	17	31
D-E	-6.6069	-10.4715	-190.447	-207.5254	95	6	16	9687	0	18	18
D-F	-23.262	-10.6488	-314.972	-348.8828	117	13	21	14334	5	32	29
D-J	0.0	0.0	-0.7473	-0.7473	4	0	1	133	0	0	1
D-K	0.0	-16.9917	-33.751	-50.7427	25	1	3	2001	1	8	13
E-F	-3.903	-15.0254	-176.756	-195.6844	93	3	16	8975	1	18	18
E-J	0.0	-53.0998	-39.5698	-92.6696	27	4	4	2517	4	11	11
E-K	0.0	0.0	-10.7256	-10.7256	10	0	0	514	0	0	0
G-H	-2.6638	-9.2765	-198.365	-210.3053	96	6	18	10110	1	20	19
G-I	-25.8503	-17.3679	-159.379	-202.5972	90	9	14	8698	1	18	17
G-J	-10.2804	44.9755	-182.667	-147.9719	92	5	2	7329	0	17	29
G-K	0.0	0.0	-6.1974	-6.1974	16	0	0	417	0	1	4
G-L	-10.7962	0.0	-50.4496	-61.2458	23	2	2	1742	0	0	1
H-I	-16.325	-8.1734	-306.921	-331.4195	116	19	22	14716	4	30	32
H-J	-11.0648	0.0	-50.6742	-61.739	24	0	2	1719	0	0	0
H-K	-20.5968	43.349	-190.295	-167.5429	88	7	2	7454	0	17	28
H-L	0.0	0.0	-0.0731	-0.0731	3	0	0	17	0	0	0
I-J	0.0	0.0	-0.0526	-0.0526	4	0	0	22	0	0	0
I-K	-10.1617	0.0	-49.9454	-60.1071	23	1	2	1687	0	0	1
I-L	0.0	43.3947	-184.964	-141.5693	93	6	2	7449	0	16	31
J-K	-14.4742	-25.2427	-205.221	-244.9379	92	4	18	10183	2	21	19
J-L	-18.3014	-10.5416	-304.126	-332.969	117	19	21	14474	4	31	29
K-L	-6.422	-22.0118	-164.325	-192.7588	89	9	15	8921	2	16	14

Interface residues

• A-B: ALA165B, ALA195B, ALA274A, ALA274B, ALA280A, ALA281A, ALA286A, ALA293A, ARG171A, ARG171B, ARG206B, ARG271A, ARG271B, ARG285A, ASN215B, ASN272A, ASN272B, ASN283A, ASN300A, ASN302A, ASN308A, ASP212B, ASP292A, GLN170B, GLU163B, GLU167B, GLU204B, GLU250A, GLU278A, GLU298A, GLY158B, GLY160B, GLY207B, GLY209B, GLY249A, GLY270A, GLY270B, GLY290A, HIS173A, HIS201B, HIS303A, ILE146A, ILE198B, ILE205B, ILE210B, ILE211B, ILE263A, ILE275A, ILE276A, ILE277A, ILE305A, LEU133B, LEU166B, LEU168A, LEU168B, LEU199B, LEU202B, LEU203B, LEU208B, LEU216B, LEU230A, LEU273B, LEU301A, LEU304A, LYS268A, LYS268B, LYS287A, LYS295A, LYS299A, MET214B, MET282A, MET289A, PHE217B, PHE267A, PHE267B, PHE284A, PHE297A, PRO196B, PRO197B, PRO266A, SER162B, SER200B, THR164B, THR264A, THR294A, THR296A, TYR147A, TYR291A, VAL169B, VAL213B, VAL232A, VAL265A, VAL269A, VAL269B, VAL279A
• A-C: ALA165A, ALA274A, ALA274C, ALA280C, ALA281C, ALA286C, ALA293C, ARG171A, ARG171C, ARG180A, ARG206A, ARG271A, ARG271C, ARG285C, ASN215A, ASN272A, ASN272C, ASN283C, ASN300C, ASN302C, ASP212A, ASP292C, GLN170A, GLN251C, GLU163A, GLU167A, GLU204A, GLU278C, GLU298C, GLY158A, GLY160A, GLY207A, GLY209A, GLY270A, GLY270C, GLY290C, HIS173C, ILE198A, ILE205A, ILE210A, ILE211A, ILE263C, ILE275C, ILE276C, ILE277C, ILE305C, LEU166A, LEU168A, LEU199A, LEU202A, LEU203A, LEU208A, LEU216A, LEU230C, LEU273A, LEU273C, LEU301C, LEU304C, LYS268C, LYS287C, LYS295C, MET282C, MET289C, PHE217A, PHE267A, PHE267C, PHE284C, PHE297C, PRO196A, PRO197A, PRO266C, SER157A, SER162A, SER200A, THR164A, THR238C, THR264C, THR294C, THR296C, TYR147C, TYR291C, VAL159A, VAL169A, VAL213A, VAL232C, VAL265C, VAL269A, VAL269C, VAL279C
• A-D: ALA195A, ALA219A, ALA219D, ALA221A, ALA221D, ALA281A, ALA281D, ALA286A, ALA286D, ARG171A, ARG171D, ARG174A, ARG174D, ARG223A, ARG223D, ARG285A, ARG285D, ASN215A, ASN215D, ASN283A, ASN283D, ASP145A, ASP145D, ASP187A, ASP187D, ASP212A, ASP212D, ASP225A, ASP225D, GLN132D, GLN186A, GLN186D, GLN189A, GLU188A, GLU224A, GLU224D, GLU278A, GLU278D, GLY148A, GLY148D, GLY150A, GLY150D, GLY172A, GLY172D, GLY218A, GLY218D, GLY220A, GLY220D, GLY290A, GLY290D, HIS173A, HIS173D, HIS201A, HIS201D, ILE146A, ILE146D, ILE176A, ILE176D, LEU149A, LEU149D, LEU175A, LEU175D, LYS287A, LYS287D, MET214A, MET214D, MET282A, MET282D, MET289A, MET289D, PHE217A, PHE217D, PHE284A, PHE284D, SER200A, SER200D, SER229D, SER288A, SER288D, THR190A, THR190D, THR226A, THR226D, THR227A, THR227D, TYR147A, TYR147D, TYR291A, TYR291D, VAL192A, VAL213A, VAL222A, VAL222D, VAL279D
• A-E: ASN300E, GLU309E, GLY290A, GLY290E, HIS303A, HIS303E, LYS295A, LYS299A, LYS299E, MET289A, MET289E, SER288A, THR296A, THR296E, TYR291A, TYR291E
• A-F: ALA219A, ALA219F, ALA221A, ALA221F, ASN215A, ASN215F, ASP212A, ASP212F, GLN170A, GLN170F, GLY218A, GLY218F, GLY220A, GLY220F, LEU216A, LEU216F, MET214A, MET214F, PHE217A, PHE217F, VAL213A, VAL213F, VAL222A, VAL222F
• B-C: ALA165C, ALA195C, ALA274B, ALA274C, ALA280B, ALA281B, ALA286B, ALA293B, ARG136C, ARG137C, ARG171B, ARG171C, ARG180C, ARG206C, ARG245B, ARG271B, ARG271C, ARG285B, ASN215C, ASN236C, ASN272B, ASN272C, ASN283B, ASN300B, ASN302B, ASN308B, ASP179C, ASP182C, ASP212C, ASP244B, ASP292B, ASP312B, GLN170C, GLN251B, GLU163C, GLU167C, GLU204C, GLU278B, GLU298B, GLU306B, GLU309B, GLU310B, GLY158C, GLY160C, GLY207C, GLY209C, GLY247B, GLY249B, GLY270B, GLY270C, GLY290B, HIS173B, HIS201C, HIS303B, HIS307B, ILE198C, ILE205C, ILE210C, ILE211C, ILE263B, ILE275B, ILE276B, ILE277B, ILE305B, LEU166C, LEU168C, LEU199C, LEU202C, LEU203C, LEU208C, LEU216C, LEU230B, LEU246B, LEU273B, LEU273C, LEU301B, LEU304B, LYS268B, LYS268C, LYS287B, LYS295B, LYS299B, MET139C, MET282B, MET289B, PHE217C, PHE243B, PHE267C, PHE284B, PHE297B, PRO196C, PRO197C, PRO266B, SER138C, SER157C, SER162C, SER200C, SER248B, THR164C, THR242B, THR264B, THR294B, THR296B, THR311B, TRP237B, TYR147B, TYR291B, VAL159C, VAL169C, VAL213C, VAL232B, VAL265B, VAL269B, VAL269C, VAL279B
• B-D: ALA219B, ALA219D, ALA221B, ALA221D, ASN215B, ASN215D, ASP212B, ASP212D, GLN170B, GLN170D, GLY218B, GLY218D, GLY220B, GLY220D, LEU216B, LEU216D, MET214B, MET214D, PHE217B, PHE217D, VAL213B, VAL213D, VAL222B, VAL222D
• B-E: ALA195E, ALA219B, ALA219E, ALA221B, ALA221E, ALA281B, ALA281E, ALA286B, ALA286E, ARG171B, ARG174B, ARG174E, ARG223B, ARG223E, ARG285B, ARG285E, ASN215B, ASN215E, ASN283B, ASN283E, ASP145B, ASP145E, ASP187E, ASP212B, ASP212E, ASP225B, ASP225E, GLN132B, GLN186B, GLN186E, GLN189E, GLU188E, GLU224B, GLU224E, GLU278B, GLY148B, GLY148E, GLY150B, GLY150E, GLY172B, GLY172E, GLY218B, GLY218E, GLY220B, GLY220E, GLY290B, GLY290E, HIS173B, HIS173E, HIS201B, HIS201E, ILE146B, ILE146E, ILE176B, ILE176E, LEU149B, LEU149E, LEU175B, LEU175E, LYS287B, LYS287E, MET214B, MET214E, MET282B, MET282E, MET289B, MET289E, PHE217B, PHE217E, PHE284B, PHE284E, SER200B, SER200E, SER229E, SER288B, SER288E, THR190B, THR190E, THR226B, THR226E, THR227B, THR227E, TYR147B, TYR147E, TYR291B, TYR291E, VAL213E, VAL222B, VAL222E, VAL279B, VAL279E
• B-F: THR296B, TYR291B, TYR291F
• C-D: THR296C, THR296D, TYR291C, TYR291D
• C-E: ALA219C, ALA219E, ALA221C, ALA221E, ASN215C, ASN215E, ASP212C, ASP212E, GLN170C, GLN170E, GLY218C, GLY218E, GLY220C, GLY220E, LEU216C, LEU216E, MET214C, MET214E, PHE217C, PHE217E, VAL213C, VAL213E, VAL222C, VAL222E
• C-F: ALA219C, ALA219F, ALA221C, ALA221F, ALA281C, ALA281F, ALA286C, ALA286F, ARG171C, ARG171F, ARG174C, ARG174F, ARG223C, ARG223F, ARG285C, ARG285F, ASN215C, ASN215F, ASN283C, ASN283F, ASP145C, ASP145F, ASP187C, ASP187F, ASP212C, ASP212F, ASP225C, ASP225F, GLN186C, GLN186F, GLU224C, GLU224F, GLU278C, GLU278F, GLY148C, GLY148F, GLY150C, GLY150F, GLY172C, GLY172F, GLY218C, GLY218F, GLY220C, GLY220F, GLY290F, HIS173C, HIS173F, HIS201C, HIS201F, ILE146C, ILE146F, ILE176C, ILE176F, LEU149C, LEU149F, LEU175C, LYS287C, LYS287F, MET214C, MET214F, MET282C, MET282F, MET289C, MET289F, PHE217C, PHE217F, PHE284C, PHE284F, SER200C, SER200F, SER229C, SER229F, SER288C, SER288F, THR190C, THR190F, THR226C, THR226F, THR227C, THR227F, TYR147C, TYR147F, TYR291C, TYR291F, VAL192C, VAL192F, VAL222C, VAL222F, VAL279C, VAL279F
• D-E: ALA165D, ALA274D, ALA274E, ALA280E, ALA281E, ALA286E, ALA293E, ARG171D, ARG171E, ARG206D, ARG271D, ARG271E, ARG285E, ASN215D, ASN272D, ASN272E, ASN283E, ASN300E, ASN302E, ASN308E, ASP212D, ASP292E, GLN170D, GLU163D, GLU167D, GLU204D, GLU250E, GLU278E, GLU298E, GLY158D, GLY160D, GLY207D, GLY209D, GLY249E, GLY270D, GLY270E, GLY290E, HIS173E, HIS201D, HIS303E, ILE146E, ILE198D, ILE205D, ILE210D, ILE211D, ILE263E, ILE275E, ILE276E, ILE277E, ILE305E, LEU166D, LEU168D, LEU168E, LEU199D, LEU202D, LEU203D, LEU208D, LEU216D, LEU230E, LEU273D, LEU301E, LEU304E, LYS268D, LYS268E, LYS287E, LYS295E, LYS299E, MET214D, MET282E, MET289E, PHE217D, PHE267D, PHE267E, PHE284E, PHE297E, PRO196D, PRO197D, PRO266E, SER162D, SER200D, SER248E, THR164D, THR264E, THR294E, THR296E, TYR147E, TYR291E, VAL159D, VAL169D, VAL213D, VAL232E, VAL265E, VAL269D, VAL269E, VAL279E
• D-F: ALA165F, ALA195F, ALA274D, ALA274F, ALA280D, ALA281D, ALA286D, ALA293D, ARG137F, ARG171D, ARG171F, ARG180F, ARG206F, ARG245D, ARG271D, ARG271F, ARG285D, ASN215F, ASN236F, ASN272D, ASN272F, ASN283D, ASN300D, ASN302D, ASN308D, ASP179F, ASP182F, ASP212F, ASP244D, ASP292D, ASP312D, GLN170F, GLN251D, GLU163F, GLU167D, GLU167F, GLU204F, GLU278D, GLU298D, GLU306D, GLU309D, GLU310D, GLY158F, GLY160F, GLY207F, GLY209F, GLY247D, GLY249D, GLY270D, GLY270F, GLY290D, HIS173D, HIS201F, HIS303D, HIS307D, ILE198F, ILE205F, ILE210F, ILE211F, ILE263D, ILE275D, ILE275F, ILE276D, ILE277D, ILE305D, LEU166F, LEU168F, LEU199F, LEU202F, LEU203F, LEU208F, LEU216F, LEU230D, LEU246D, LEU273D, LEU273F, LEU301D, LEU304D, LYS268D, LYS268F, LYS287D, LYS295D, LYS299D, MET214F, MET282D, MET289D, PHE217F, PHE243D, PHE267F, PHE284D, PHE297D, PRO196F, PRO197F, PRO239D, PRO266D, SER138F, SER157F, SER162F, SER200F, SER248D, THR164F, THR242D, THR264D, THR294D, THR296D, THR311D, TRP237D, TYR147D, TYR291D, VAL159F, VAL169F, VAL213F, VAL232D, VAL265D, VAL269D, VAL269F, VAL279D
• D-J: GLU135J, ILE198D, ILE198J, LEU133D
• D-K: ARG136D, ARG137D, ARG180D, ASN300K, ASN302K, ASP178D, ASP179D, ASP182D, GLU135D, GLU306K, HIS140D, HIS307K, ILE198D, ILE305K, LEU199D, LEU202D, LEU301K, LEU304K, MET139D, PHE256D, PHE297K, PRO196D, PRO197D, SER138D, VAL181D
• E-F: ALA165E, ALA274E, ALA274F, ALA280F, ALA281F, ALA286F, ALA293F, ARG171E, ARG171F, ARG180E, ARG206E, ARG271E, ARG271F, ARG285F, ASN215E, ASN272E, ASN272F, ASN283F, ASN300F, ASN302F, ASP212E, ASP292F, GLN170E, GLN251F, GLU163E, GLU167E, GLU167F, GLU204E, GLU250F, GLU278F, GLU298F, GLY158E, GLY160E, GLY172E, GLY207E, GLY209E, GLY270E, GLY270F, GLY290F, HIS173F, ILE146F, ILE198E, ILE205E, ILE210E, ILE211E, ILE263F, ILE275F, ILE276F, ILE277F, LEU166E, LEU168E, LEU168F, LEU199E, LEU202E, LEU203E, LEU208E, LEU216E, LEU230F, LEU273E, LEU273F, LEU301F, LEU304F, LYS268E, LYS268F, LYS287F, LYS295F, LYS299F, MET282F, MET289F, PHE217E, PHE267E, PHE267F, PHE284F, PHE297F, PRO196E, PRO197E, PRO266F, SER162E, SER200E, THR164E, THR264F, THR294F, THR296F, TYR147F, TYR291F, VAL159E, VAL169E, VAL213E, VAL232F, VAL265F, VAL269E, VAL269F, VAL279F
• E-J: ARG136J, ARG137J, ARG180J, ASN300E, ASN302E, ASN308E, ASP178J, ASP179J, ASP182J, GLU135J, GLU306E, HIS140J, HIS307E, ILE198J, ILE210J, ILE305E, LEU199J, LEU202J, LEU301E, LEU304E, MET139J, PHE297E, PRO196J, PRO197J, SER138J, VAL181J, VAL183J
• E-K: GLU298E, GLU298K, ILE305E, ILE305K, LEU301E, LEU301K, LEU304E, LEU304K, PHE297E, PHE297K
• G-H: ALA165H, ALA274G, ALA274H, ALA280G, ALA281G, ALA286G, ALA293G, ARG136H, ARG171G, ARG171H, ARG206H, ARG271G, ARG271H, ARG285G, ASN215H, ASN272G, ASN272H, ASN283G, ASN300G, ASN302G, ASN308G, ASP212H, ASP292G, GLN170H, GLU163H, GLU167G, GLU167H, GLU250G, GLU278G, GLU298G, GLY158H, GLY160H, GLY207H, GLY209H, GLY270G, GLY270H, GLY290G, HIS173G, HIS201H, HIS303G, ILE146G, ILE198H, ILE205H, ILE210H, ILE211H, ILE263G, ILE275G, ILE276G, ILE277G, ILE305G, LEU166H, LEU168H, LEU199H, LEU202H, LEU203H, LEU208H, LEU216H, LEU230G, LEU273G, LEU273H, LEU301G, LEU304G, LYS161H, LYS268G, LYS268H, LYS287G, LYS295G, LYS299G, MET214H, MET282G, MET289G, PHE217H, PHE267G, PHE267H, PHE284G, PHE297G, PRO196H, PRO197H, PRO266G, SER157H, SER162H, SER200H, THR164H, THR264G, THR294G, THR296G, TYR147G, TYR291G, VAL159H, VAL169H, VAL213H, VAL232G, VAL265G, VAL269G, VAL269H, VAL279G
• G-I: ALA165G, ALA274G, ALA274I, ALA280I, ALA281I, ALA286I, ALA293I, ARG171G, ARG171I, ARG206G, ARG271G, ARG271I, ARG285I, ASN215G, ASN272G, ASN272I, ASN283I, ASN300I, ASN302I, ASP212G, ASP292I, GLN170G, GLU163G, GLU167G, GLU167I, GLU204G, GLU250I, GLU278I, GLU298I, GLY158G, GLY160G, GLY172G, GLY207G, GLY209G, GLY270G, GLY270I, GLY290I, HIS173I, HIS303I, ILE146I, ILE198G, ILE205G, ILE210G, ILE211G, ILE263I, ILE275I, ILE276I, ILE277I, LEU166G, LEU168G, LEU168I, LEU199G, LEU202G, LEU203G, LEU208G, LEU216G, LEU230I, LEU273G, LEU273I, LEU301I, LEU304I, LYS268G, LYS268I, LYS287I, LYS295I, MET282I, MET289I, PHE217G, PHE267G, PHE267I, PHE284I, PHE297I, PRO197G, PRO266I, SER162G, SER200G, THR164G, THR264I, THR294I, THR296I, TYR147I, TYR291I, VAL159G, VAL169G, VAL213G, VAL232I, VAL265I, VAL269G, VAL269I, VAL279I
• G-J: ALA195G, ALA219G, ALA219J, ALA221G, ALA221J, ALA281G, ALA281J, ALA286G, ALA286J, ARG171J, ARG174G, ARG174J, ARG223G, ARG223J, ARG285G, ARG285J, ASN215G, ASN215J, ASN283G, ASN283J, ASP145G, ASP145J, ASP187G, ASP187J, ASP212G, ASP212J, ASP225G, ASP225J, GLN186G, GLN186J, GLU224G, GLU224J, GLU278G, GLU278J, GLY148G, GLY148J, GLY150G, GLY150J, GLY172G, GLY172J, GLY218G, GLY218J, GLY220G, GLY220J, GLY290J, HIS173G, HIS173J, HIS201G, HIS201J, ILE146G, ILE146J, ILE176G, ILE176J, LEU149G, LEU149J, LEU175G, LEU175J, LYS287G, LYS287J, MET214G, MET214J, MET282G, MET282J, MET289G, MET289J, PHE217G, PHE217J, PHE284G, PHE284J, SER200G, SER200J, SER229J, SER288G, SER288J, THR190G, THR190J, THR226G, THR226J, THR227G, THR227J, TYR147G, TYR147J, TYR184G, TYR291G, TYR291J, VAL192G, VAL192J, VAL213G, VAL222G, VAL222J, VAL279G, VAL279J
• G-K: ASN300G, ASN300K, GLY290G, GLY290K, HIS303G, HIS303K, LYS295G, LYS295K, LYS299G, LYS299K, MET289G, MET289K, THR296G, THR296K, TYR291G, TYR291K
• G-L: ALA219G, ALA219L, ALA221G, ALA221L, ASN215G, ASN215L, ASP212G, ASP212L, GLN170L, GLY218G, GLY218L, GLY220G, GLY220L, LEU216G, LEU216L, MET214G, MET214L, PHE217G, PHE217L, VAL213G, VAL213L, VAL222G, VAL222L
• H-I: ALA165I, ALA195I, ALA274H, ALA274I, ALA280H, ALA281H, ALA286H, ALA293H, ARG136I, ARG137I, ARG171H, ARG171I, ARG180I, ARG206I, ARG245H, ARG271H, ARG271I, ARG285H, ASN215I, ASN272H, ASN272I, ASN283H, ASN300H, ASN302H, ASN308H, ASP179I, ASP182I, ASP212I, ASP244H, ASP292H, GLN170I, GLN251H, GLU163I, GLU167H, GLU167I, GLU204I, GLU278H, GLU298H, GLU306H, GLU310H, GLY158I, GLY160I, GLY207I, GLY209I, GLY247H, GLY249H, GLY270H, GLY270I, GLY290H, HIS173H, HIS201I, HIS303H, HIS307H, ILE198I, ILE205I, ILE210I, ILE211I, ILE263H, ILE275H, ILE276H, ILE277H, ILE305H, LEU166I, LEU168I, LEU199I, LEU202I, LEU203I, LEU208I, LEU216I, LEU230H, LEU246H, LEU273H, LEU273I, LEU301H, LEU304H, LYS241H, LYS268H, LYS268I, LYS287H, LYS295H, LYS299H, MET139I, MET282H, MET289H, PHE217I, PHE243H, PHE267I, PHE284H, PHE297H, PRO196I, PRO197I, PRO266H, SER138I, SER157I, SER162I, SER200I, SER248H, THR164I, THR238H, THR242H, THR264H, THR294H, THR296H, THR311H, TRP237H, TYR147H, TYR291H, VAL159I, VAL169I, VAL181I, VAL213I, VAL232H, VAL265H, VAL269H, VAL269I, VAL279H
• H-J: ALA219H, ALA219J, ALA221H, ALA221J, ASN215H, ASN215J, ASP212H, ASP212J, GLN170H, GLN170J, GLY218H, GLY218J, GLY220H, GLY220J, LEU216H, LEU216J, MET214H, MET214J, PHE217H, PHE217J, VAL213H, VAL213J, VAL222H, VAL222J
• H-K: ALA195K, ALA219H, ALA219K, ALA221H, ALA221K, ALA281H, ALA281K, ALA286H, ALA286K, ARG171H, ARG174H, ARG174K, ARG223H, ARG223K, ARG285H, ARG285K, ASN215H, ASN215K, ASN283H, ASN283K, ASP145H, ASP145K, ASP187H, ASP212H, ASP212K, ASP225H, ASP225K, GLN186H, GLN186K, GLU224H, GLU224K, GLU278H, GLU278K, GLY148H, GLY148K, GLY150H, GLY150K, GLY172H, GLY172K, GLY218H, GLY218K, GLY220H, GLY220K, GLY290H, GLY290K, HIS173H, HIS173K, HIS201H, HIS201K, ILE146H, ILE146K, ILE176H, ILE176K, LEU149H, LEU149K, LEU175H, LEU175K, LYS287H, LYS287K, MET214H, MET214K, MET282H, MET282K, MET289H, MET289K, PHE217K, PHE284H, PHE284K, SER200H, SER200K, SER229K, SER288H, SER288K, THR190H, THR190K, THR226H, THR226K, THR227H, THR227K, TYR147H, TYR147K, TYR291H, TYR291K, VAL192K, VAL213K, VAL222H, VAL222K, VAL279H
• H-L: THR296H, TYR291H, TYR291L
• I-J: THR296I, THR296J, TYR291I, TYR291J
• I-K: ALA219I, ALA219K, ALA221I, ALA221K, ASN215I, ASN215K, ASP212I, ASP212K, GLN170I, GLY218I, GLY218K, GLY220I, GLY220K, LEU216I, LEU216K, MET214I, MET214K, PHE217I, PHE217K, VAL213I, VAL213K, VAL222I, VAL222K
• I-L: ALA195I, ALA195L, ALA219I, ALA219L, ALA221I, ALA221L, ALA281I, ALA281L, ALA286I, ALA286L, ARG171I, ARG171L, ARG174I, ARG174L, ARG223I, ARG223L, ARG285I, ARG285L, ASN215I, ASN215L, ASN283I, ASN283L, ASP145I, ASP145L, ASP187I, ASP187L, ASP212I, ASP212L, ASP225I, ASP225L, GLN186I, GLN186L, GLU224I, GLU224L, GLU278I, GLU278L, GLY148I, GLY148L, GLY150I, GLY150L, GLY172I, GLY172L, GLY218I, GLY218L, GLY220I, GLY220L, GLY290I, GLY290L, HIS173I, HIS173L, HIS201I, HIS201L, ILE146I, ILE146L, ILE176I, ILE176L, LEU149I, LEU149L, LEU175I, LEU175L, LYS287I, LYS287L, MET214I, MET214L, MET282I, MET282L, MET289I, MET289L, PHE217I, PHE217L, PHE284I, PHE284L, SER200I, SER200L, SER229I, SER288I, SER288L, THR190I, THR190L, THR226I, THR226L, THR227I, THR227L, TYR147I, TYR147L, TYR291I, TYR291L, VAL169I, VAL192L, VAL222I, VAL222L, VAL279I, VAL279L
• J-K: ALA165J, ALA274J, ALA274K, ALA280K, ALA281K, ALA286K, ALA293K, ARG171J, ARG171K, ARG206J, ARG271J, ARG271K, ARG285K, ASN215J, ASN272J, ASN272K, ASN283K, ASN300K, ASN302K, ASN308K, ASP212J, ASP292K, GLN170J, GLU163J, GLU167J, GLU278K, GLU298K, GLY158J, GLY160J, GLY207J, GLY209J, GLY249K, GLY270J, GLY270K, HIS173K, HIS201J, HIS303K, ILE146K, ILE198J, ILE205J, ILE210J, ILE211J, ILE263K, ILE275K, ILE276K, ILE277K, ILE305K, LEU166J, LEU168J, LEU199J, LEU202J, LEU203J, LEU208J, LEU216J, LEU230K, LEU273J, LEU273K, LEU301K, LEU304K, LYS268J, LYS268K, LYS287K, LYS295K, LYS299K, MET214J, MET282K, MET289K, PHE217J, PHE267J, PHE267K, PHE284K, PHE297K, PRO196J, PRO197J, PRO266K, SER157J, SER162J, SER200J, THR164J, THR264K, THR294K, THR296K, TYR147K, TYR291K, VAL159J, VAL169J, VAL213J, VAL232K, VAL265K, VAL269J, VAL269K, VAL279K
• J-L: ALA165L, ALA195L, ALA274J, ALA274L, ALA280J, ALA281J, ALA286J, ALA293J, ARG136L, ARG137L, ARG171J, ARG171L, ARG180L, ARG206L, ARG245J, ARG271J, ARG271L, ARG285J, ASN215L, ASN272J, ASN272L, ASN283J, ASN300J, ASN302J, ASN308J, ASP179L, ASP182L, ASP212L, ASP244J, ASP292J, ASP312J, GLN170L, GLN251J, GLU163L, GLU167J, GLU167L, GLU204L, GLU278J, GLU298J, GLU306J, GLU309J, GLU310J, GLY158L, GLY160L, GLY207L, GLY209L, GLY247J, GLY249J, GLY270J, GLY270L, GLY290J, HIS173J, HIS201L, HIS303J, HIS307J, ILE146J, ILE198L, ILE205L, ILE210L, ILE211L, ILE263J, ILE275J, ILE275L, ILE276J, ILE277J, ILE305J, LEU166L, LEU168L, LEU199L, LEU202L, LEU203L, LEU208L, LEU216L, LEU230J, LEU246J, LEU273J, LEU273L, LEU301J, LEU304J, LYS268J, LYS287J, LYS295J, LYS299J, MET139L, MET214L, MET282J, MET289J, PHE217L, PHE243J, PHE267L, PHE284J, PHE297J, PRO196L, PRO197L, PRO266J, SER138L, SER157L, SER162L, SER200L, SER248J, THR164L, THR242J, THR264J, THR294J, THR296J, THR311J, TRP237J, TYR147J, TYR291J, VAL159L, VAL169L, VAL213L, VAL232J, VAL265J, VAL269J, VAL269L, VAL279J
• K-L: ALA165K, ALA274L, ALA280L, ALA281L, ALA286L, ALA293L, ARG171K, ARG171L, ARG180K, ARG206K, ARG271K, ARG271L, ARG285L, ASN215K, ASN272K, ASN272L, ASN283L, ASN300L, ASP212K, ASP292L, GLN170K, GLU163K, GLU167K, GLU167L, GLU204K, GLU250L, GLU278L, GLU298L, GLY158K, GLY160K, GLY172K, GLY207K, GLY209K, GLY270K, GLY270L, GLY290L, HIS173L, ILE146L, ILE198K, ILE205K, ILE210K, ILE211K, ILE263L, ILE275L, ILE276L, ILE277L, LEU166K, LEU168K, LEU168L, LEU199K, LEU202K, LEU203K, LEU208K, LEU216K, LEU230L, LEU273K, LEU273L, LEU301L, LEU304L, LYS268L, LYS287L, LYS295L, MET282L, MET289L, PHE217K, PHE267K, PHE267L, PHE284L, PHE297L, PRO196K, PRO197K, PRO266L, SER157K, SER162K, SER200K, THR164K, THR264L, THR294L, THR296L, TYR147L, TYR291L, VAL159K, VAL169K, VAL213K, VAL232L, VAL265L, VAL269K, VAL269L, VAL279L