2QC8

crystal structure of human glutamine synthetase in complex with adp and methionine sulfoximine phosphate

• Total interactions analyzed: 45
• Total true interactions: 30
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 185
  • Norm. En. per Res.: -4.6605
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-166.4948	-101.5807	-556.285	-824.3605	179	26	10	21895	9	59	58
A-C	0.0	0.0	-0.0015	-0.0015	2	0	0	1	0	0	0
A-D	0.0	0.0	-0.0021	-0.0021	2	0	0	1	0	0	0
A-E	-164.387	-97.3944	-554.804	-816.5854	181	32	10	21744	10	58	58
A-F	-12.4238	3.4505	-17.4217	-26.395	16	0	0	469	0	2	2
A-G	-22.5896	0.0	-60.5101	-83.0997	34	2	1	2280	0	0	0
B-C	-167.4325	-100.5313	-583.649	-851.6128	185	28	9	21994	10	58	58
B-D	0.0	0.0	-0.0053	-0.0053	2	0	0	3	0	0	0
B-E	0.0	0.0	-0.0052	-0.0052	2	0	0	3	0	0	0
B-F	-23.9637	0.0	-62.8513	-86.815	35	2	1	2328	0	0	0
B-J	-13.7215	2.4063	-17.6048	-28.92	16	2	0	508	0	2	2
C-D	-180.0215	-102.5975	-579.57	-862.1891	185	27	10	22043	10	58	57
C-E	0.0	0.0	-0.0034	-0.0034	2	0	0	2	0	0	0
C-I	-13.5226	1.3716	-17.3116	-29.4626	16	1	0	506	0	2	2
C-J	-21.4629	0.0	-57.0524	-78.5153	34	4	1	2216	0	0	0
D-E	-168.6503	-98.6467	-578.148	-845.445	183	30	10	22016	9	58	58
D-H	-7.8636	2.4217	-18.0823	-23.5242	16	0	0	492	0	2	2
D-I	-22.8883	0.0	-61.9543	-84.8426	35	2	1	2301	0	0	0
E-G	0.0	3.5482	-18.9466	-15.3984	16	1	0	497	0	2	2
E-H	-24.0327	0.0	-57.863	-81.8957	33	2	1	2228	0	0	0
F-G	-166.8987	-103.2299	-570.583	-840.7116	182	25	9	21886	11	58	58
F-H	0.0	0.0	-0.0014	-0.0014	2	0	0	1	0	0	0
F-I	0.0	0.0	-0.0016	-0.0016	2	0	0	1	0	0	0
F-J	-159.7835	-94.3311	-553.278	-807.3926	180	27	9	21680	10	57	57
G-H	-150.1836	-98.1315	-563.306	-811.6211	184	26	11	21807	10	57	58
G-I	0.0	0.0	-0.003	-0.003	2	0	0	2	0	0	0
G-J	0.0	0.0	-0.0045	-0.0045	2	0	0	3	0	0	0
H-I	-165.9455	-97.9488	-560.466	-824.3604	185	29	10	22087	9	57	58
H-J	0.0	0.0	-0.0035	-0.0035	2	0	0	2	0	0	0
I-J	-169.0924	-94.6836	-560.71	-824.486	181	25	9	21707	10	57	57

Interface residues

• A-B: ALA167B, ALA170B, ALA178B, ALA182B, ALA186B, ALA191B, ALA195B, ALA236A, ALA28A, ALA317B, ALA321B, ARG106A, ARG169B, ARG173B, ARG181B, ARG222A, ARG227A, ARG227B, ARG319B, ARG324B, ARG327B, ARG340B, ARG41A, ARG45A, ARG86B, ARG90A, ARG90B, ASN105A, ASN10A, ASN10B, ASN194B, ASN248B, ASN318B, ASN61A, ASN74A, ASN94A, ASP143A, ASP168B, ASP174B, ASP231A, ASP231B, ASP34A, ASP48A, ASP63A, ASP76A, ASP87A, ASP87B, ASP92A, ASP92B, CYS163B, CYS183B, CYS229A, CYS229B, CYS42A, GLN158B, GLN15A, GLN15B, GLN205B, GLN22A, GLN27A, GLN331B, GLN69A, GLU177B, GLU196B, GLU203B, GLU230A, GLU230B, GLU24A, GLU305B, GLU38A, GLU59A, GLU71A, GLY12A, GLY12B, GLY141A, GLY144A, GLY148B, GLY159B, GLY164B, GLY166B, GLY172B, GLY187B, GLY192B, GLY207B, GLY233A, GLY233B, GLY23A, GLY315B, GLY330B, GLY39A, GLY64A, GLY72A, HIS179B, HIS226A, ILE13A, ILE175B, ILE190B, ILE224A, ILE224B, ILE235A, ILE31A, ILE325B, LEU184B, LEU20A, LEU225A, LEU40A, LEU47A, LEU68A, LEU79A, LYS103A, LYS11A, LYS11B, LYS14A, LYS14B, LYS189B, LYS25A, LYS43A, LYS91A, LYS91B, MET140A, MET18A, MET18B, MET198B, MET29A, MET77A, PHE102A, PHE147B, PHE204B, PHE223A, PHE232A, PHE232B, PHE62A, PHE89A, PHE89B, PRO160B, PRO21A, PRO326B, PRO88B, PRO93A, SER19A, SER320B, SER65A, SER66A, SER70A, SER73A, SER75A, THR142A, THR193B, THR237A, THR328B, THR36A, THR44A, THR46A, THR67A, TRP202B, TRP32A, TRP60A, TYR104A, TYR161B, TYR162B, TYR171B, TYR17A, TYR180B, TYR185B, TYR30A, TYR336B, TYR78A, VAL165B, VAL16A, VAL176B, VAL188B, VAL197B, VAL228A, VAL228B, VAL234A, VAL234B, VAL26A, VAL316B, VAL329B
• A-C: ASP174C, ILE13A
• A-D: ASP174A, ILE13D
• A-E: ALA167A, ALA170A, ALA178A, ALA182A, ALA186A, ALA191A, ALA195A, ALA236E, ALA28E, ALA317A, ALA321A, ARG106E, ARG169A, ARG173A, ARG181A, ARG222E, ARG227A, ARG227E, ARG319A, ARG324A, ARG327A, ARG340A, ARG41E, ARG45E, ARG86A, ARG90A, ARG90E, ASN105E, ASN10A, ASN10E, ASN194A, ASN248A, ASN318A, ASN61E, ASN74E, ASN94E, ASP143E, ASP168A, ASP174A, ASP231A, ASP231E, ASP34E, ASP48E, ASP63E, ASP76E, ASP87A, ASP87E, ASP92A, ASP92E, CYS163A, CYS183A, CYS229A, CYS229E, CYS42E, GLN158A, GLN15A, GLN15E, GLN205A, GLN22E, GLN27E, GLN331A, GLN69E, GLU177A, GLU196A, GLU203A, GLU230A, GLU230E, GLU24E, GLU305A, GLU332A, GLU38E, GLU59E, GLU71E, GLY12A, GLY12E, GLY141E, GLY144E, GLY148A, GLY159A, GLY164A, GLY166A, GLY172A, GLY187A, GLY192A, GLY207A, GLY233A, GLY233E, GLY23E, GLY315A, GLY330A, GLY39E, GLY64E, GLY72E, HIS179A, HIS226E, ILE13E, ILE175A, ILE190A, ILE224A, ILE224E, ILE235E, ILE31E, ILE325A, LEU184A, LEU20E, LEU225E, LEU40E, LEU47E, LEU68E, LEU79E, LYS103E, LYS11A, LYS11E, LYS14A, LYS14E, LYS189A, LYS25E, LYS43E, LYS91A, LYS91E, MET140E, MET18A, MET18E, MET198A, MET29E, MET77E, PHE102E, PHE147A, PHE204A, PHE223E, PHE232A, PHE232E, PHE62E, PHE89A, PHE89E, PRO160A, PRO21E, PRO326A, PRO88A, PRO93E, SER19A, SER19E, SER320A, SER65E, SER66E, SER70E, SER73E, SER75E, THR142E, THR193A, THR237E, THR328A, THR36E, THR44E, THR46E, THR67E, TRP202A, TRP32E, TRP60E, TYR104E, TYR161A, TYR162A, TYR171A, TYR17E, TYR180A, TYR185A, TYR30E, TYR336A, TYR78E, VAL165A, VAL16E, VAL176A, VAL188A, VAL197A, VAL228A, VAL228E, VAL234A, VAL234E, VAL26E, VAL316A, VAL329A
• A-F: ASN152A, ASN152F, ASP143A, ASP143F, GLY141A, GLY141F, GLY144A, GLY144F, HIS145A, HIS145F, ILE235A, ILE235F, SER151A, SER151F, THR142A, THR142F
• A-G: ASN152A, ASN152G, ASN246A, ASN246G, ASP168A, ASP168G, GLY148A, GLY148G, GLY153A, GLY153G, GLY156A, GLY156G, GLY245A, GLY245G, HIS145A, HIS145G, PHE154A, PHE154G, PRO150A, PRO150G, PRO155A, PRO155G, PRO157A, PRO157G, SER151A, SER151G, TRP149A, TRP149G, TRP247A, TRP247G, TYR161A, TYR161G, TYR171A, TYR171G
• B-C: ALA167C, ALA170C, ALA178C, ALA182C, ALA186C, ALA191C, ALA195C, ALA236B, ALA28B, ALA317C, ALA321C, ARG106B, ARG169C, ARG173C, ARG181C, ARG222B, ARG227B, ARG227C, ARG319C, ARG324C, ARG327C, ARG340C, ARG41B, ARG45B, ARG86C, ARG90B, ARG90C, ASN105B, ASN10B, ASN10C, ASN194C, ASN248C, ASN318C, ASN61B, ASN74B, ASN94B, ASP143B, ASP168C, ASP174C, ASP231B, ASP231C, ASP34B, ASP48B, ASP63B, ASP76B, ASP87B, ASP87C, ASP92B, ASP92C, CYS163C, CYS183C, CYS229B, CYS229C, CYS42B, GLN158C, GLN15B, GLN15C, GLN205C, GLN22B, GLN27B, GLN331C, GLN69B, GLU134C, GLU177C, GLU196C, GLU203C, GLU230B, GLU230C, GLU24B, GLU305C, GLU332C, GLU338C, GLU38B, GLU59B, GLU71B, GLY12B, GLY12C, GLY141B, GLY144B, GLY148C, GLY159C, GLY164C, GLY166C, GLY172C, GLY187C, GLY192C, GLY207C, GLY233B, GLY233C, GLY23B, GLY315C, GLY330C, GLY39B, GLY64B, GLY72B, HIS179C, HIS226B, HIS253C, ILE13B, ILE175C, ILE190C, ILE224B, ILE224C, ILE235B, ILE31B, ILE325C, LEU184C, LEU20B, LEU225B, LEU40B, LEU47B, LEU68B, LEU79B, LYS103B, LYS11B, LYS11C, LYS14B, LYS14C, LYS189C, LYS25B, LYS43B, LYS91B, LYS91C, MET140B, MET18B, MET18C, MET198C, MET29B, MET77B, PHE102B, PHE147C, PHE204C, PHE223B, PHE232B, PHE232C, PHE62B, PHE89B, PHE89C, PRO160C, PRO208C, PRO21B, PRO326C, PRO88C, PRO93B, SER19B, SER19C, SER320C, SER65B, SER66B, SER70B, SER73B, SER75B, THR142B, THR193C, THR237B, THR328C, THR36B, THR44B, THR46B, THR67B, TRP202C, TRP32B, TRP60B, TYR104B, TYR161C, TYR162C, TYR171C, TYR17B, TYR180C, TYR185C, TYR30B, TYR336C, TYR78B, VAL165C, VAL16B, VAL176C, VAL188C, VAL197C, VAL228B, VAL228C, VAL234B, VAL234C, VAL26B, VAL316C, VAL329C
• B-D: ASP174D, ILE13B
• B-E: ASP174B, ILE13E
• B-F: ASN152B, ASN152F, ASN246B, ASN246F, ASP168B, ASP168F, GLY148B, GLY148F, GLY153B, GLY153F, GLY156B, GLY156F, GLY245B, GLY245F, HIS145B, HIS145F, PHE154B, PHE154F, PRO150B, PRO150F, PRO155B, PRO155F, PRO157B, PRO157F, PRO244F, SER151B, SER151F, TRP149B, TRP149F, TRP247B, TRP247F, TYR161B, TYR161F, TYR171B, TYR171F
• B-J: ASN152B, ASN152J, ASP143B, ASP143J, GLY141B, GLY141J, GLY144B, GLY144J, HIS145B, HIS145J, ILE235B, ILE235J, SER151B, SER151J, THR142B, THR142J
• C-D: ALA167D, ALA170D, ALA178D, ALA182D, ALA186D, ALA191D, ALA195D, ALA236C, ALA28C, ALA317D, ALA321D, ARG106C, ARG169D, ARG173D, ARG181D, ARG222C, ARG227C, ARG227D, ARG319D, ARG324D, ARG327D, ARG340D, ARG41C, ARG45C, ARG86D, ARG90C, ARG90D, ASN105C, ASN10C, ASN10D, ASN194D, ASN248D, ASN318D, ASN61C, ASN74C, ASN94C, ASP143C, ASP168D, ASP174D, ASP231C, ASP231D, ASP34C, ASP48C, ASP63C, ASP76C, ASP87C, ASP87D, ASP92C, ASP92D, CYS163D, CYS183D, CYS229C, CYS229D, CYS42C, GLN158D, GLN15C, GLN15D, GLN205D, GLN22C, GLN27C, GLN331D, GLN69C, GLU134D, GLU177D, GLU196D, GLU203D, GLU230C, GLU230D, GLU24C, GLU305D, GLU332D, GLU338D, GLU38C, GLU59C, GLU71C, GLY12C, GLY12D, GLY141C, GLY144C, GLY148D, GLY159D, GLY164D, GLY166D, GLY172D, GLY187D, GLY192D, GLY207D, GLY233C, GLY233D, GLY23C, GLY315D, GLY330D, GLY39C, GLY64C, GLY72C, HIS179D, HIS226C, HIS253D, ILE13C, ILE175D, ILE190D, ILE224C, ILE224D, ILE235C, ILE31C, ILE325D, LEU184D, LEU20C, LEU225C, LEU40C, LEU47C, LEU68C, LEU79C, LYS103C, LYS11C, LYS11D, LYS14C, LYS14D, LYS189D, LYS25C, LYS43C, LYS91C, LYS91D, MET140C, MET18C, MET18D, MET198D, MET29C, MET77C, PHE102C, PHE147D, PHE204D, PHE223C, PHE232C, PHE232D, PHE62C, PHE89C, PHE89D, PRO160D, PRO208D, PRO21C, PRO326D, PRO88D, PRO93C, SER19C, SER19D, SER320D, SER65C, SER66C, SER70C, SER73C, SER75C, THR142C, THR193D, THR237C, THR328D, THR36C, THR44C, THR46C, THR67C, TRP202D, TRP32C, TRP60C, TYR104C, TYR161D, TYR162D, TYR171D, TYR17C, TYR180D, TYR185D, TYR30C, TYR336D, TYR78C, VAL165D, VAL16C, VAL176D, VAL188D, VAL197D, VAL228C, VAL228D, VAL234C, VAL234D, VAL26C, VAL316D, VAL329D
• C-E: ASP174E, ILE13C
• C-I: ASN152C, ASN152I, ASP143C, ASP143I, GLY141C, GLY141I, GLY144C, GLY144I, HIS145C, HIS145I, ILE235C, ILE235I, SER151C, SER151I, THR142C, THR142I
• C-J: ASN152C, ASN152J, ASN246C, ASN246J, ASP168C, ASP168J, GLY148C, GLY148J, GLY153C, GLY153J, GLY156C, GLY156J, GLY245C, GLY245J, HIS145C, HIS145J, PHE154C, PHE154J, PRO150C, PRO150J, PRO155C, PRO155J, PRO157C, PRO157J, SER151C, SER151J, TRP149C, TRP149J, TRP247C, TRP247J, TYR161C, TYR161J, TYR171C, TYR171J
• D-E: ALA167E, ALA170E, ALA178E, ALA182E, ALA186E, ALA191E, ALA195E, ALA236D, ALA28D, ALA317E, ALA321E, ARG106D, ARG169E, ARG173E, ARG181E, ARG222D, ARG227D, ARG227E, ARG319E, ARG324E, ARG327E, ARG340E, ARG41D, ARG45D, ARG86E, ARG90D, ARG90E, ASN105D, ASN10D, ASN10E, ASN194E, ASN248E, ASN318E, ASN61D, ASN74D, ASN94D, ASP143D, ASP168E, ASP174E, ASP231D, ASP231E, ASP34D, ASP48D, ASP63D, ASP76D, ASP87D, ASP87E, ASP92D, ASP92E, CYS163E, CYS183E, CYS229D, CYS229E, CYS42D, GLN158E, GLN15D, GLN15E, GLN205E, GLN22D, GLN27D, GLN331E, GLN69D, GLU177E, GLU196E, GLU203E, GLU230D, GLU230E, GLU24D, GLU305E, GLU332E, GLU338E, GLU38D, GLU59D, GLU71D, GLY12D, GLY12E, GLY141D, GLY144D, GLY148E, GLY159E, GLY164E, GLY166E, GLY172E, GLY187E, GLY192E, GLY207E, GLY233D, GLY233E, GLY23D, GLY315E, GLY330E, GLY39D, GLY64D, GLY72D, HIS179E, HIS226D, HIS253E, ILE13D, ILE175E, ILE190E, ILE224D, ILE224E, ILE235D, ILE31D, ILE325E, LEU184E, LEU20D, LEU225D, LEU40D, LEU47D, LEU68D, LEU79D, LYS103D, LYS11D, LYS11E, LYS14D, LYS14E, LYS189E, LYS25D, LYS43D, LYS91D, LYS91E, MET140D, MET18D, MET18E, MET198E, MET29D, MET77D, PHE102D, PHE147E, PHE204E, PHE223D, PHE232D, PHE232E, PHE62D, PHE89D, PHE89E, PRO160E, PRO208E, PRO21D, PRO326E, PRO88E, PRO93D, SER19D, SER320E, SER65D, SER66D, SER70D, SER73D, SER75D, THR142D, THR193E, THR237D, THR328E, THR36D, THR44D, THR46D, THR67D, TRP202E, TRP32D, TRP60D, TYR104D, TYR161E, TYR162E, TYR171E, TYR17D, TYR180E, TYR185E, TYR30D, TYR336E, TYR78D, VAL165E, VAL16D, VAL176E, VAL188E, VAL197E, VAL228D, VAL228E, VAL234D, VAL234E, VAL26D, VAL316E, VAL329E
• D-H: ASN152D, ASN152H, ASP143D, ASP143H, GLY141D, GLY141H, GLY144D, GLY144H, HIS145D, HIS145H, ILE235D, ILE235H, SER151D, SER151H, THR142D, THR142H
• D-I: ASN152D, ASN152I, ASN246D, ASN246I, ASP168D, ASP168I, GLY148D, GLY148I, GLY153D, GLY153I, GLY156D, GLY156I, GLY245D, GLY245I, HIS145D, HIS145I, PHE154D, PHE154I, PRO150D, PRO150I, PRO155D, PRO155I, PRO157D, PRO157I, PRO244D, SER151D, SER151I, TRP149D, TRP149I, TRP247D, TRP247I, TYR161D, TYR161I, TYR171D, TYR171I
• E-G: ASN152E, ASN152G, ASP143E, ASP143G, GLY141E, GLY141G, GLY144E, GLY144G, HIS145E, HIS145G, ILE235E, ILE235G, SER151E, SER151G, THR142E, THR142G
• E-H: ASN152E, ASN152H, ASN246E, ASN246H, ASP168E, ASP168H, GLY148E, GLY148H, GLY153E, GLY153H, GLY156E, GLY156H, GLY245E, GLY245H, HIS145E, HIS145H, PHE154E, PHE154H, PRO150E, PRO150H, PRO155E, PRO155H, PRO157E, PRO157H, SER151E, SER151H, TRP149E, TRP149H, TRP247E, TRP247H, TYR161E, TYR161H, TYR171H
• F-G: ALA167G, ALA170G, ALA178G, ALA182G, ALA186G, ALA191G, ALA195G, ALA236F, ALA28F, ALA317G, ALA321G, ARG106F, ARG169G, ARG173G, ARG181G, ARG222F, ARG227F, ARG227G, ARG319G, ARG324G, ARG327G, ARG340G, ARG41F, ARG45F, ARG86G, ARG90F, ARG90G, ASN105F, ASN10F, ASN10G, ASN194G, ASN248G, ASN318G, ASN61F, ASN74F, ASN94F, ASP143F, ASP168G, ASP174G, ASP231F, ASP231G, ASP34F, ASP48F, ASP63F, ASP76F, ASP87F, ASP87G, ASP92F, ASP92G, CYS163G, CYS183G, CYS229F, CYS229G, CYS42F, GLN158G, GLN15F, GLN15G, GLN205G, GLN22F, GLN27F, GLN331G, GLN69F, GLU177G, GLU196G, GLU203G, GLU230F, GLU230G, GLU24F, GLU305G, GLU332G, GLU38F, GLU59F, GLU71F, GLY12F, GLY12G, GLY141F, GLY144F, GLY159G, GLY164G, GLY166G, GLY172G, GLY187G, GLY192G, GLY207G, GLY233F, GLY233G, GLY23F, GLY315G, GLY330G, GLY39F, GLY64F, GLY72F, HIS179G, HIS226F, HIS226G, ILE13F, ILE175G, ILE190G, ILE206G, ILE224F, ILE224G, ILE235F, ILE31F, ILE325G, LEU184G, LEU20F, LEU225F, LEU225G, LEU40F, LEU47F, LEU68F, LEU79F, LYS103F, LYS11F, LYS11G, LYS14F, LYS14G, LYS189G, LYS25F, LYS43F, LYS91F, LYS91G, MET140F, MET18F, MET18G, MET29F, MET77F, PHE102F, PHE147G, PHE204G, PHE223F, PHE232F, PHE232G, PHE62F, PHE89F, PHE89G, PRO160G, PRO208G, PRO21F, PRO326G, PRO88G, PRO93F, SER19F, SER320G, SER65F, SER66F, SER70F, SER73F, SER75F, THR142F, THR193G, THR237F, THR328G, THR36F, THR44F, THR46F, THR67F, TRP202G, TRP32F, TRP60F, TYR104F, TYR161G, TYR162G, TYR171G, TYR17F, TYR180G, TYR185G, TYR30F, TYR336G, TYR78F, VAL165G, VAL16F, VAL176G, VAL188G, VAL197G, VAL228F, VAL228G, VAL234F, VAL234G, VAL26F, VAL316G, VAL329G
• F-H: ASP174H, ILE13F
• F-I: ASP174F, ILE13I
• F-J: ALA167F, ALA170F, ALA178F, ALA182F, ALA186F, ALA191F, ALA195F, ALA236J, ALA28J, ALA317F, ALA321F, ARG106J, ARG169F, ARG173F, ARG181F, ARG222J, ARG227F, ARG227J, ARG319F, ARG324F, ARG327F, ARG340F, ARG41J, ARG45J, ARG86F, ARG90F, ARG90J, ASN105J, ASN10F, ASN10J, ASN194F, ASN248F, ASN318F, ASN61J, ASN74J, ASN94J, ASP143J, ASP168F, ASP174F, ASP231F, ASP231J, ASP34J, ASP48J, ASP63J, ASP76J, ASP87F, ASP87J, ASP92F, ASP92J, CYS163F, CYS183F, CYS229F, CYS229J, CYS42J, GLN158F, GLN15F, GLN15J, GLN205F, GLN22J, GLN27J, GLN331F, GLN69J, GLU177F, GLU196F, GLU203F, GLU230F, GLU230J, GLU24J, GLU305F, GLU332F, GLU38J, GLU59J, GLU71J, GLY12F, GLY12J, GLY141J, GLY144J, GLY159F, GLY164F, GLY166F, GLY172F, GLY187F, GLY192F, GLY207F, GLY233F, GLY233J, GLY23J, GLY315F, GLY39J, GLY64J, GLY72J, HIS179F, HIS226F, HIS226J, HIS253F, ILE13J, ILE175F, ILE190F, ILE206F, ILE224F, ILE224J, ILE235J, ILE31J, ILE325F, LEU184F, LEU20J, LEU225F, LEU225J, LEU40J, LEU47J, LEU68J, LEU79J, LYS103J, LYS11F, LYS11J, LYS14F, LYS14J, LYS189F, LYS25J, LYS43J, LYS91F, LYS91J, MET140J, MET18F, MET18J, MET29J, MET77J, PHE102J, PHE147F, PHE204F, PHE223J, PHE232F, PHE232J, PHE62J, PHE89F, PHE89J, PRO160F, PRO21J, PRO326F, PRO88F, PRO93J, SER19J, SER320F, SER65J, SER66J, SER70J, SER73J, SER75J, THR142J, THR193F, THR328F, THR36J, THR44J, THR46J, THR67J, TRP202F, TRP32J, TRP60J, TYR104J, TYR161F, TYR162F, TYR171F, TYR17J, TYR180F, TYR185F, TYR30J, TYR336F, TYR78J, VAL165F, VAL16J, VAL176F, VAL188F, VAL197F, VAL228F, VAL228J, VAL234F, VAL234J, VAL26J, VAL316F, VAL329F
• G-H: ALA167H, ALA170H, ALA178H, ALA182H, ALA186H, ALA191H, ALA195H, ALA236G, ALA28G, ALA317H, ALA321H, ARG106G, ARG169H, ARG173H, ARG181H, ARG222G, ARG227G, ARG227H, ARG319H, ARG324H, ARG327H, ARG340H, ARG41G, ARG45G, ARG86H, ARG90G, ARG90H, ASN105G, ASN10G, ASN10H, ASN194H, ASN248H, ASN318H, ASN61G, ASN74G, ASN94G, ASP143G, ASP168H, ASP174H, ASP231G, ASP231H, ASP34G, ASP48G, ASP63G, ASP76G, ASP87G, ASP87H, ASP92G, ASP92H, CYS163H, CYS183H, CYS229G, CYS229H, CYS42G, GLN158H, GLN15G, GLN15H, GLN205H, GLN22G, GLN27G, GLN331H, GLN69G, GLU177H, GLU196H, GLU203H, GLU230G, GLU230H, GLU24G, GLU305H, GLU332H, GLU338H, GLU38G, GLU59G, GLU71G, GLY12G, GLY12H, GLY141G, GLY144G, GLY159H, GLY164H, GLY166H, GLY172H, GLY187H, GLY192H, GLY207H, GLY233G, GLY233H, GLY23G, GLY315H, GLY330H, GLY39G, GLY64G, GLY72G, HIS179H, HIS226G, HIS226H, HIS253H, ILE13G, ILE175H, ILE190H, ILE206H, ILE224G, ILE224H, ILE235G, ILE31G, ILE325H, LEU184H, LEU20G, LEU225G, LEU225H, LEU40G, LEU47G, LEU68G, LEU79G, LYS103G, LYS11G, LYS11H, LYS14G, LYS14H, LYS189H, LYS25G, LYS43G, LYS91G, LYS91H, MET140G, MET18G, MET18H, MET29G, MET77G, PHE102G, PHE147H, PHE204H, PHE223G, PHE232G, PHE232H, PHE62G, PHE89G, PHE89H, PRO160H, PRO208H, PRO21G, PRO326H, PRO88H, PRO93G, SER19G, SER320H, SER65G, SER66G, SER70G, SER73G, SER75G, THR142G, THR193H, THR237G, THR328H, THR36G, THR44G, THR46G, THR67G, TRP202H, TRP32G, TRP60G, TYR104G, TYR161H, TYR162H, TYR171H, TYR17G, TYR180H, TYR185H, TYR30G, TYR336H, TYR78G, VAL165H, VAL16G, VAL176H, VAL188H, VAL197H, VAL228G, VAL228H, VAL234G, VAL234H, VAL26G, VAL316H, VAL329H
• G-I: ASP174I, ILE13G
• G-J: ASP174G, ILE13J
• H-I: ALA167I, ALA170I, ALA178I, ALA182I, ALA186I, ALA191I, ALA195I, ALA236H, ALA28H, ALA317I, ALA321I, ARG106H, ARG169I, ARG173I, ARG181I, ARG222H, ARG227H, ARG227I, ARG319I, ARG324I, ARG327I, ARG340I, ARG41H, ARG45H, ARG86I, ARG90H, ARG90I, ASN105H, ASN10H, ASN10I, ASN194I, ASN248I, ASN318I, ASN61H, ASN74H, ASN94H, ASP143H, ASP168I, ASP174I, ASP231H, ASP231I, ASP34H, ASP48H, ASP63H, ASP76H, ASP87H, ASP87I, ASP92H, ASP92I, CYS163I, CYS183I, CYS229H, CYS229I, CYS42H, GLN158I, GLN15H, GLN15I, GLN205I, GLN22H, GLN27H, GLN331I, GLN69H, GLU177I, GLU196I, GLU203I, GLU230H, GLU230I, GLU24H, GLU305I, GLU332I, GLU338I, GLU38H, GLU59H, GLU71H, GLY12H, GLY12I, GLY141H, GLY144H, GLY159I, GLY164I, GLY166I, GLY172I, GLY187I, GLY192I, GLY207I, GLY233H, GLY233I, GLY23H, GLY315I, GLY330I, GLY39H, GLY64H, GLY72H, HIS179I, HIS226H, HIS226I, HIS253I, ILE13H, ILE175I, ILE190I, ILE206I, ILE224H, ILE224I, ILE235H, ILE31H, ILE325I, LEU184I, LEU20H, LEU225H, LEU225I, LEU40H, LEU47H, LEU68H, LEU79H, LYS103H, LYS11H, LYS11I, LYS14H, LYS14I, LYS189I, LYS25H, LYS43H, LYS91H, LYS91I, MET140H, MET18H, MET18I, MET198I, MET29H, MET77H, PHE102H, PHE147I, PHE204I, PHE223H, PHE232H, PHE232I, PHE62H, PHE89H, PHE89I, PRO160I, PRO208I, PRO21H, PRO326I, PRO88I, PRO93H, SER19H, SER320I, SER65H, SER66H, SER70H, SER73H, SER75H, THR142H, THR193I, THR237H, THR328I, THR36H, THR44H, THR46H, THR67H, TRP202I, TRP32H, TRP60H, TYR104H, TYR161I, TYR162I, TYR171I, TYR17H, TYR180I, TYR185I, TYR30H, TYR336I, TYR78H, VAL165I, VAL16H, VAL176I, VAL188I, VAL197I, VAL228H, VAL228I, VAL234H, VAL234I, VAL26H, VAL316I, VAL329I
• H-J: ASP174J, ILE13H
• I-J: ALA167J, ALA170J, ALA178J, ALA182J, ALA186J, ALA191J, ALA195J, ALA236I, ALA28I, ALA317J, ALA321J, ARG106I, ARG169J, ARG173J, ARG181J, ARG222I, ARG227I, ARG227J, ARG319J, ARG324J, ARG327J, ARG340J, ARG41I, ARG45I, ARG86J, ARG90I, ARG90J, ASN105I, ASN10I, ASN10J, ASN194J, ASN248J, ASN318J, ASN61I, ASN74I, ASN94I, ASP168J, ASP174J, ASP231I, ASP231J, ASP34I, ASP48I, ASP63I, ASP76I, ASP87I, ASP87J, ASP92I, ASP92J, CYS163J, CYS183J, CYS229I, CYS229J, CYS42I, GLN158J, GLN15I, GLN15J, GLN205J, GLN22I, GLN27I, GLN331J, GLN69I, GLU177J, GLU196J, GLU203J, GLU230I, GLU230J, GLU24I, GLU305J, GLU332J, GLU338J, GLU38I, GLU59I, GLU71I, GLY12I, GLY12J, GLY141I, GLY144I, GLY159J, GLY164J, GLY166J, GLY172J, GLY187J, GLY192J, GLY207J, GLY233I, GLY233J, GLY23I, GLY315J, GLY39I, GLY64I, GLY72I, HIS179J, HIS226I, HIS253J, ILE13I, ILE175J, ILE190J, ILE206J, ILE224I, ILE224J, ILE235I, ILE31I, ILE325J, LEU184J, LEU20I, LEU225I, LEU225J, LEU40I, LEU47I, LEU68I, LEU79I, LYS103I, LYS11I, LYS11J, LYS14I, LYS14J, LYS189J, LYS25I, LYS43I, LYS91I, LYS91J, MET140I, MET18I, MET18J, MET29I, MET77I, PHE102I, PHE147J, PHE204J, PHE223I, PHE232I, PHE232J, PHE62I, PHE89I, PHE89J, PRO160J, PRO208J, PRO21I, PRO326J, PRO88J, PRO93I, SER19I, SER320J, SER65I, SER66I, SER70I, SER73I, SER75I, THR142I, THR193J, THR237I, THR328J, THR36I, THR44I, THR46I, THR67I, TRP202J, TRP32I, TRP60I, TYR104I, TYR161J, TYR162J, TYR171J, TYR17I, TYR180J, TYR185J, TYR30I, TYR336J, TYR78I, VAL165J, VAL16I, VAL176J, VAL188J, VAL197J, VAL228I, VAL228J, VAL234I, VAL234J, VAL26I, VAL316J, VAL329J