2Q9Q

the crystal structure of full length human gins complex

• Total interactions analyzed: 28
• Total true interactions: 20
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 165
  • Norm. En. per Res.: -4.5936
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-138.7018	-102.5193	-516.72	-757.9411	165	36	10	20515	10	57	42
A-C	-19.3096	-24.0752	-34.7897	-78.1745	25	1	0	1632	2	9	7
A-D	-10.0896	-8.9426	-407.543	-426.5752	140	14	14	16479	1	34	33
A-G	0.0	58.6427	-83.015	-24.3723	57	1	2	3829	0	27	30
A-H	0.0	0.0	-0.5444	-0.5444	4	0	0	65	0	0	0
B-C	-40.9978	-43.7916	-406.516	-491.3054	158	24	13	18220	2	38	46
B-D	0.0	0.0	-39.8266	-39.8266	38	1	3	2189	0	13	10
B-E	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	1
B-G	-8.5	-27.743	-17.0347	-53.2777	19	2	0	764	2	10	9
B-H	-5.2045	-12.9454	-43.6642	-61.8141	43	3	0	2194	0	16	14
C-D	-47.1297	-38.3908	-425.988	-511.5085	138	29	16	17297	6	46	44
D-E	0.0	0.0	-0.7807	-0.7807	4	0	0	53	0	4	1
D-G	0.0	0.0	-0.716	-0.716	15	0	0	170	0	4	2
D-H	0.0	0.0	-0.0069	-0.0069	2	0	0	4	0	1	0
E-F	-108.0035	-112.9457	-507.319	-728.2682	172	26	10	20242	10	56	43
E-G	-2.687	-20.508	-39.6445	-62.8395	27	0	0	1748	1	9	6
E-H	-29.5574	-17.1798	-439.346	-486.0831	141	17	13	17315	2	35	33
F-G	-21.9334	-47.4499	-426.926	-496.3093	154	11	13	18501	2	40	43
F-H	0.0	-2.1071	-57.2403	-59.3474	45	5	3	2353	0	14	10
G-H	-31.566	-72.9741	-429.75	-534.2901	141	21	15	17717	9	46	41

Interface residues

• A-B: ALA10A, ALA132A, ALA141A, ALA143A, ALA163A, ALA24B, ALA49A, ALA4A, ARG124A, ARG171A, ARG174B, ARG192B, ARG207B, ARG55A, ARG84B, ARG86B, ARG94B, ASN147A, ASN154A, ASN165A, ASN173A, ASN51A, ASN64B, ASP146A, ASP166B, ASP168B, ASP187B, ASP189B, ASP193B, ASP197B, ASP24A, ASP2A, ASP32A, ASP72B, CYS53B, GLN138A, GLN139A, GLN162A, GLN175A, GLN203B, GLN221B, GLN32B, GLN54A, GLN57B, GLN79B, GLU11A, GLU13A, GLU140A, GLU152A, GLU185B, GLU199B, GLU25B, GLU28B, GLU31B, GLU56B, GLU59B, GLU5A, GLU62B, GLU7A, GLU81B, GLU83B, GLY157A, GLY201B, GLY30A, GLY31A, HIS142A, HIS166A, HIS204B, HIS60B, HIS78B, ILE153A, ILE196B, ILE206B, ILE211B, ILE26A, ILE27B, ILE29A, ILE50A, ILE77B, ILE85B, LEU128A, LEU145A, LEU148A, LEU150A, LEU160A, LEU164A, LEU167B, LEU173B, LEU174A, LEU198B, LEU205B, LEU222B, LEU23A, LEU26B, LEU28A, LEU30B, LEU33A, LEU46A, LEU48A, LEU52A, LEU58B, LEU73B, LEU89B, LEU98A, LEU9A, LYS12A, LYS144A, LYS169A, LYS200B, LYS209B, LYS25A, LYS38B, LYS57A, LYS74B, MET167A, MET1A, MET35B, MET61B, MET80B, MET82B, PHE135A, PHE159A, PHE172B, PHE21A, PHE36A, PHE39B, PHE8A, PRO165B, PRO186B, PRO23B, PRO35A, PRO41B, PRO45A, PRO90A, SER156A, SER169B, SER202B, SER22A, SER76B, SER91B, THR149A, THR158A, THR161A, THR172A, THR188B, THR210B, THR22B, TRP34B, TRP47A, TYR168A, TYR170B, TYR194B, TYR208B, TYR27A, TYR87B, TYR91A, VAL136A, VAL171B, VAL175B, VAL184B, VAL44A, VAL54B, VAL6A, VAL75B, VAL88B
• A-C: ALA10A, ALA3A, ALA4A, ARG55A, ASN51A, ASP2A, GLN54A, GLU11A, GLU5A, GLU7A, HIS102A, ILE50A, LEU98A, LEU9A, LYS141C, LYS144C, LYS97A, MET140C, MET1A, PHE8A, PRO142C, PRO143C, SER145C, TRP47A, VAL6A
• A-D: ALA10A, ALA126A, ALA12D, ALA132A, ALA132D, ALA156D, ALA163A, ALA3A, ALA4A, ARG114A, ARG129A, ARG137A, ARG145D, ARG147D, ARG148D, ARG171A, ARG173D, ASN101A, ASN105D, ASN131D, ASN154A, ASN155D, ASN158D, ASN165A, ASN173A, ASN184D, ASP103D, ASP122A, ASP127D, ASP133A, ASP133D, ASP151D, ASP185D, ASP2A, CYS188D, GLN122D, GLN136D, GLN138A, GLN139A, GLN140D, GLN154D, GLN162A, GLN175A, GLN177D, GLN180D, GLN187D, GLN193D, GLU11A, GLU130D, GLU152A, GLU170D, GLU172D, GLU190D, GLU5A, GLU7A, GLU94A, GLU9D, GLY118D, GLY11D, GLY120D, GLY144D, GLY14D, GLY157A, GLY174D, GLY179D, GLY182D, GLY192D, HIS102A, HIS125D, HIS166A, ILE125A, ILE134D, ILE143D, ILE149D, LEU124D, LEU128A, LEU138D, LEU139D, LEU13D, LEU160A, LEU164A, LEU168D, LEU170A, LEU174A, LEU175D, LEU183D, LEU46A, LEU95A, LEU98A, LYS118A, LYS127A, LYS169A, LYS181D, LYS191D, LYS97A, MET150D, MET151A, MET167A, MET171D, MET1A, MET93A, PHE116D, PHE135A, PHE142D, PHE146D, PHE159A, PHE176D, PHE186D, PHE8A, PRO104D, PRO15D, SER10D, SER121D, SER128D, SER131A, SER134A, SER135D, SER137D, SER152D, SER153D, SER156A, THR141D, THR149A, THR155A, THR158A, THR161A, THR172A, THR178D, THR96A, TRP121A, TRP189D, TYR117D, TYR157D, TYR168A, TYR91A, TYR92A, VAL117A, VAL130A, VAL136A, VAL6A
• A-G: ALA101G, ALA107G, ALA132A, ALA141A, ALA143A, ALA16G, ALA23G, ARG103G, ARG11G, ARG129A, ARG137A, ARG15G, ARG171A, ARG30G, ARG83G, ARG86G, ASN100G, ASN25G, ASP133A, ASP146A, ASP27G, GLN138A, GLN139A, GLN20G, GLN31G, GLU12G, GLU140A, GLU18G, GLU26G, GLU81A, GLU82A, GLY19G, GLY28G, HIS105G, HIS142A, HIS77A, LEU102G, LEU21G, LEU90G, LEU98G, LYS127A, LYS144A, LYS80A, MET106G, PHE104G, PHE135A, PHE24G, PRO17G, PRO22G, PRO99G, SER131A, SER134A, THR83A, THR85A, TYR94G, VAL130A, VAL136A
• A-H: GLN175A, GLN193H, LEU174A, LYS191H
• B-C: ALA107C, ALA108C, ALA122C, ALA128B, ALA130B, ALA135B, ALA145B, ALA161B, ALA38C, ALA78C, ALA89C, ARG119C, ARG126C, ARG160B, ARG30C, ARG65C, ARG71C, ARG73C, ARG74C, ARG83C, ARG84B, ARG86B, ARG88C, ARG91C, ARG94B, ARG96B, ASN115C, ASN116C, ASN136B, ASN143B, ASN152B, ASN43C, ASN72C, ASP131C, ASP135C, ASP139C, ASP157B, ASP82C, CYS75C, CYS95B, GLN138C, GLN154B, GLN44C, GLN79B, GLU101B, GLU109C, GLU110C, GLU112C, GLU125B, GLU126B, GLU132B, GLU132C, GLU138B, GLU26C, GLU34C, GLU35C, GLU41C, GLU52B, GLU56B, GLU59B, GLU81B, GLU83B, GLY129C, GLY130C, GLY133C, HIS148B, HIS66C, ILE100B, ILE136C, ILE85B, ILE87C, LEU121C, LEU122B, LEU127B, LEU128C, LEU134C, LEU141B, LEU146B, LEU153B, LEU158B, LEU29C, LEU33C, LEU39C, LEU58B, LEU69C, LEU70C, LEU80C, LEU84C, LEU85C, LEU89B, LEU93B, LEU97B, LYS102B, LYS118C, LYS141C, LYS142B, LYS144C, LYS147B, LYS155B, LYS37C, LYS38B, LYS99B, MET106C, MET111C, MET125C, MET134B, MET140C, MET149B, MET36C, MET55B, MET80B, MET82B, MET98B, PHE103B, PHE104B, PHE114C, PHE129B, PHE133B, PHE24C, PRO105B, PRO124B, PRO142C, PRO143C, PRO150B, PRO151B, PRO163B, SER120C, SER123B, SER127C, SER139B, SER145C, SER46B, SER68C, SER90B, SER91B, THR123C, THR137B, THR137C, THR76C, TRP113C, TRP34B, TRP92C, TYR117C, TYR124C, TYR140B, TYR40C, TYR79C, TYR81C, TYR87B, TYR92B, VAL144B, VAL156B, VAL162B, VAL32C, VAL51B, VAL54B, VAL77C, VAL88B
• B-D: ALA161B, ALA4D, ARG160B, ARG192B, ARG7D, ARG94B, ASN18D, ASP157B, ASP166B, CYS95B, GLU101B, GLU16D, GLU17D, GLU3D, GLU9D, GLY11D, GLY14D, LEU139D, LEU141B, LEU146B, LEU158B, LEU20D, LYS102B, LYS164B, MET149B, MET98B, PHE103B, PHE104B, PHE19D, PHE6D, PRO105B, PRO163B, SER10D, SER21D, THR137B, VAL156B, VAL162B, VAL8D
• B-E: ASP2E, GLN191B
• B-G: ALA16G, ARG11G, ARG15G, ARG192B, ASP189B, ASP193B, ASP197B, GLN191B, GLN20G, GLU18G, GLU199B, HIS14G, HIS204B, ILE196B, PRO17G, PRO186B, TYR194B, VAL184B, VAL195B
• B-H: ALA163H, ALA166H, ARG167H, ARG173H, ARG178B, ARG192B, ASN155H, ASN181B, ASN184H, ASP108H, ASP160H, ASP185H, ASP189B, ASP193B, ASP197B, CYS188H, GLN177H, GLN180H, GLN187H, GLN191B, GLU170H, GLU180B, GLU190B, GLY182H, HIS110H, ILE182B, ILE196B, LEU168H, LEU183B, LEU183H, LYS111H, LYS181H, LYS191H, PHE176H, PHE186H, SER153H, SER162H, THR161H, THR178H, THR188B, TYR194B, VAL165H, VAL195B
• C-D: ALA12D, ALA16C, ALA39D, ALA45D, ALA4D, ALA50C, ALA59D, ALA6C, ALA73D, ALA78C, ALA89C, ARG11C, ARG15C, ARG173D, ARG42D, ARG55C, ARG65C, ARG71C, ARG73C, ARG74C, ARG7D, ARG82D, ARG83C, ARG86C, ARG88C, ARG91C, ASN18D, ASN43C, ASN58D, ASN72C, ASP23D, ASP24D, ASP46C, ASP57C, ASP57D, ASP78D, ASP82C, CYS3C, CYS67C, CYS75C, GLN20C, GLN42C, GLU12C, GLU16D, GLU170D, GLU17D, GLU18C, GLU30D, GLU35C, GLU37D, GLU3D, GLU49C, GLU4C, GLU67D, GLU8C, GLU93C, GLU9D, GLY11D, GLY192D, GLY19C, GLY44D, GLY54C, GLY75D, HIS115D, HIS14C, HIS29D, HIS66C, ILE10C, ILE25D, ILE59C, ILE62C, ILE83D, ILE87C, LEU13C, LEU20D, LEU22D, LEU26D, LEU39C, LEU43D, LEU58C, LEU68D, LEU69C, LEU70C, LEU70D, LEU72D, LEU76D, LEU80C, LEU84C, LEU84D, LEU85C, LEU90C, LEU9C, LYS141C, LYS144C, LYS31D, LYS63C, LYS74D, MET140C, MET1C, MET27D, MET40D, MET7C, PHE19D, PHE2C, PHE46D, PHE47D, PHE64C, PHE6D, PHE77D, PRO142C, PRO17C, PRO41D, PRO60C, PRO69D, SER10D, SER21D, SER28D, SER2D, SER45C, SER56C, SER68C, THR36D, THR38D, THR56D, THR61C, THR76C, TRP189D, TRP71D, TRP92C, TYR117C, TYR5D, TYR79C, TYR81C, TYR94C, VAL47C, VAL60D, VAL77C, VAL8D
• D-E: ARG81D, GLN54E, GLN56E, PRO129D
• D-G: ALA101G, ARG147D, ARG148D, ASN100G, GLN136D, GLN140D, GLY144D, ILE143D, LYS141G, PHE104G, PHE146D, PRO129D, PRO99G, SER145G, TYR94G
• D-H: ALA132D, GLN193H
• E-F: ALA10E, ALA132E, ALA141E, ALA143E, ALA163E, ALA24F, ALA49E, ALA4E, ARG124E, ARG171E, ARG174F, ARG192F, ARG207F, ARG55E, ARG84F, ARG86F, ARG94F, ASN147E, ASN154E, ASN165E, ASN173E, ASN51E, ASN64F, ASP146E, ASP166F, ASP168F, ASP187F, ASP189F, ASP193F, ASP197F, ASP24E, ASP2E, ASP32E, ASP72F, CYS53F, CYS58E, CYS95F, GLN138E, GLN139E, GLN162E, GLN175E, GLN203F, GLN221F, GLN32F, GLN54E, GLN57F, GLN79F, GLU11E, GLU13E, GLU140E, GLU152E, GLU185F, GLU199F, GLU25F, GLU28F, GLU31F, GLU56F, GLU59F, GLU5E, GLU62F, GLU7E, GLU81F, GLU83F, GLY157E, GLY201F, GLY30E, GLY31E, GLY34E, HIS142E, HIS166E, HIS204F, HIS60F, HIS78F, ILE153E, ILE182F, ILE196F, ILE206F, ILE211F, ILE26E, ILE27F, ILE29E, ILE50E, ILE77F, ILE85F, LEU128E, LEU145E, LEU148E, LEU150E, LEU160E, LEU164E, LEU167F, LEU173F, LEU174E, LEU183F, LEU198F, LEU205F, LEU222F, LEU23E, LEU26F, LEU28E, LEU30F, LEU33E, LEU46E, LEU48E, LEU52E, LEU58F, LEU65F, LEU73F, LEU89F, LEU9E, LYS12E, LYS144E, LYS169E, LYS200F, LYS209F, LYS25E, LYS38F, LYS57E, LYS74F, MET167E, MET1E, MET35F, MET61F, MET80F, MET82F, MET98F, PHE135E, PHE159E, PHE172F, PHE21E, PHE36E, PHE39F, PHE84E, PHE8E, PRO186F, PRO19E, PRO23F, PRO35E, PRO41F, PRO45E, PRO90E, SER156E, SER169F, SER202F, SER22E, SER76F, SER91F, THR149E, THR158E, THR161E, THR172E, THR188F, THR210F, THR22F, TRP34F, TRP47E, TYR168E, TYR170F, TYR194F, TYR208F, TYR27E, TYR87F, TYR91E, VAL136E, VAL171F, VAL175F, VAL184F, VAL44E, VAL54F, VAL6E, VAL75F, VAL88F
• E-G: ALA10E, ALA3E, ALA4E, ARG55E, ASN51E, ASP2E, GLN54E, GLU11E, GLU5E, GLU7E, HIS102E, ILE50E, LEU48E, LEU52E, LEU98E, LEU9E, LYS141G, LYS144G, LYS97E, MET140G, MET1E, PHE8E, PRO142G, PRO143G, SER145G, TRP47E, VAL6E
• E-H: ALA10E, ALA126E, ALA12H, ALA132E, ALA132H, ALA156H, ALA163E, ALA3E, ALA4E, ARG114E, ARG129E, ARG137E, ARG145H, ARG147H, ARG148H, ARG171E, ARG173H, ASN101E, ASN105H, ASN131H, ASN154E, ASN155H, ASN158H, ASN165E, ASN173E, ASN184H, ASN18H, ASP122E, ASP127H, ASP133E, ASP133H, ASP151H, ASP185H, ASP2E, CYS188H, GLN122H, GLN136H, GLN138E, GLN139E, GLN140H, GLN154H, GLN162E, GLN175E, GLN177H, GLN180H, GLN187H, GLN193H, GLU11E, GLU130H, GLU140E, GLU152E, GLU16H, GLU170H, GLU172H, GLU190H, GLU3H, GLU5E, GLU7E, GLU94E, GLU9H, GLY118H, GLY11H, GLY120H, GLY144H, GLY14H, GLY157E, GLY174H, GLY179H, GLY182H, GLY192H, HIS102E, HIS125H, HIS166E, ILE125E, ILE134H, ILE143H, ILE149H, LEU124H, LEU128E, LEU138H, LEU139H, LEU13H, LEU160E, LEU164E, LEU168H, LEU170E, LEU174E, LEU175H, LEU183H, LEU95E, LEU98E, LYS118E, LYS127E, LYS169E, LYS181H, LYS191H, LYS97E, MET150H, MET151E, MET167E, MET171H, MET1E, MET93E, PHE116H, PHE135E, PHE142H, PHE146H, PHE159E, PHE176H, PHE186H, PHE8E, PRO104H, PRO15H, SER10H, SER121H, SER128H, SER131E, SER134E, SER135H, SER137H, SER152H, SER153H, SER156E, THR141H, THR155E, THR158E, THR161E, THR172E, THR178H, THR96E, TRP121E, TRP189H, TYR117H, TYR157H, TYR168E, TYR91E, TYR92E, VAL117E, VAL130E, VAL136E, VAL6E
• F-G: ALA107G, ALA108G, ALA122G, ALA128F, ALA130F, ALA135F, ALA145F, ALA161F, ALA38G, ALA78G, ALA89G, ARG119G, ARG126G, ARG131F, ARG160F, ARG30G, ARG71G, ARG73G, ARG74G, ARG83G, ARG84F, ARG86F, ARG88G, ARG94F, ARG96F, ASN115G, ASN116G, ASN136F, ASN143F, ASN152F, ASN43G, ASN72G, ASP131G, ASP135G, ASP139G, ASP157F, ASP82G, CYS95F, GLN138G, GLN154F, GLN44G, GLN79F, GLU101F, GLU109G, GLU110G, GLU112G, GLU125F, GLU126F, GLU132F, GLU132G, GLU138F, GLU26G, GLU34G, GLU35G, GLU41G, GLU52F, GLU56F, GLU59F, GLU81F, GLU83F, GLY129G, GLY130G, GLY133G, HIS148F, HIS66G, ILE100F, ILE136G, ILE85F, ILE87G, LEU121G, LEU127F, LEU128G, LEU134G, LEU141F, LEU146F, LEU153F, LEU158F, LEU29G, LEU33G, LEU39G, LEU58F, LEU69G, LEU70G, LEU80G, LEU84G, LEU85G, LEU89F, LEU93F, LEU97F, LYS102F, LYS118G, LYS141G, LYS142F, LYS144G, LYS147F, LYS155F, LYS37G, LYS38F, LYS99F, MET106G, MET111G, MET125G, MET134F, MET140G, MET149F, MET36G, MET55F, MET80F, MET82F, MET98F, PHE103F, PHE104F, PHE114G, PHE129F, PHE133F, PHE24G, PRO105F, PRO124F, PRO142G, PRO143G, PRO150F, PRO151F, PRO163F, SER120G, SER123F, SER127G, SER139F, SER145G, SER90F, SER91F, THR123G, THR137F, THR137G, THR76G, TRP113G, TRP34F, TRP92G, TYR117G, TYR124G, TYR140F, TYR40G, TYR79G, TYR81G, TYR87F, TYR92F, VAL144F, VAL156F, VAL162F, VAL32G, VAL47G, VAL51F, VAL54F, VAL77G, VAL88F
• F-H: ALA161F, ALA4H, ARG160F, ARG7H, ARG94F, ASN18H, ASP157F, ASP187F, CYS95F, GLU101F, GLU16H, GLU17H, GLU3H, GLU9H, GLY11H, HIS106F, ILE100F, LEU139H, LEU141F, LEU146F, LEU158F, LEU20H, LEU97F, LYS102F, LYS164F, LYS99F, MET149F, MET150H, MET98F, PHE103F, PHE104F, PHE129F, PHE133F, PHE172F, PHE19H, PHE6H, PRO105F, PRO163F, SER10H, SER21H, THR137F, TYR5H, VAL156F, VAL162F, VAL8H
• G-H: ALA12H, ALA16G, ALA38G, ALA39H, ALA45H, ALA4H, ALA50G, ALA59H, ALA6G, ALA73H, ALA78G, ALA89G, ARG11G, ARG15G, ARG173H, ARG42H, ARG65G, ARG71G, ARG73G, ARG74G, ARG7H, ARG82H, ARG83G, ARG86G, ARG88G, ARG91G, ASN18H, ASN43G, ASN58H, ASN72G, ASP23H, ASP24H, ASP46G, ASP57G, ASP57H, ASP78H, ASP82G, CYS3G, CYS67G, CYS75G, GLN122H, GLN193H, GLN20G, GLN42G, GLU12G, GLU16H, GLU170H, GLU17H, GLU18G, GLU30H, GLU35G, GLU37H, GLU3H, GLU49G, GLU4G, GLU67H, GLU8G, GLU93G, GLU9H, GLY11H, GLY192H, GLY19G, GLY44H, GLY75H, HIS115H, HIS14G, HIS29H, HIS66G, ILE10G, ILE25H, ILE59G, ILE62G, ILE83H, ILE87G, LEU13G, LEU20H, LEU22H, LEU26H, LEU39G, LEU43H, LEU58G, LEU66H, LEU68H, LEU69G, LEU70G, LEU70H, LEU72H, LEU76H, LEU80G, LEU84G, LEU84H, LEU85G, LEU90G, LEU9G, LYS141G, LYS144G, LYS31H, LYS63G, LYS74H, MET140G, MET1G, MET27H, MET40H, MET7G, PHE19H, PHE2G, PHE46H, PHE47H, PHE64G, PHE6H, PHE77H, PRO142G, PRO17G, PRO41H, PRO60G, PRO69H, SER10H, SER21H, SER28H, SER2H, SER45G, SER56G, SER68G, THR36H, THR38H, THR56H, THR61G, THR76G, TRP189H, TRP71H, TRP92G, TYR117G, TYR5H, TYR79G, TYR81G, TYR94G, VAL34H, VAL47G, VAL60H, VAL77G, VAL8H