2Q7N

crystal structure of leukemia inhibitory factor in complex with lif receptor (domains 1-5)

• Total interactions analyzed: 171
• Total true interactions: 6
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 93
  • Norm. En. per Res.: -2.7397
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-13.4574	9.4522	-225.51	-229.5152	88	12	5	10076	1	18	14
A-C	0.0	7.9653	-28.3034	-20.3381	30	0	3	1439	0	5	7
A-D	-7.612	-9.0577	-62.2559	-78.9256	55	3	0	2934	0	10	11
B-C	-9.902	-6.1397	-62.227	-78.2687	48	3	0	2917	0	10	13
B-D	0.0	0.7264	-230.166	-229.4396	112	25	9	12421	0	17	28
C-D	-38.6148	15.2692	-231.449	-254.7946	93	10	5	9897	2	17	14

Interface residues

• A-B: ALA108B, ALA47B, ARG317A, ASN105B, ASN201A, ASN205A, ASN236A, ASN261A, ASN265A, ASN318A, ASN54B, ASN55B, ASN63B, ASP154B, ASP210A, ASP271A, ASP272A, ASP273A, ASP57B, CYS60B, GLN101B, GLN157B, GLN164B, GLN209A, GLN233A, GLN48B, GLU203A, GLU260A, GLU338A, GLU50B, GLY152B, GLY235A, GLY263A, GLY276A, GLY315A, GLY339A, GLY49B, GLY61B, ILE103B, ILE234A, ILE266A, ILE267A, ILE269A, ILE337A, LEU104B, LEU109B, LEU238A, LEU313A, LEU59B, LYS102B, LYS153B, LYS158B, LYS159B, LYS160B, LYS211A, LYS58B, PHE101A, PHE156B, PHE207A, PHE268A, PHE280A, PHE52B, PRO106B, PRO208A, PRO316A, PRO51B, PRO53B, SER107B, SER151B, SER259A, SER262A, THR202A, THR204A, THR237A, THR264A, THR270A, THR277A, THR46B, TRP198A, TYR275A, TYR44B, TYR45B, VAL155B, VAL206A, VAL274A, VAL278A, VAL279A, VAL314A
• A-C: ALA425A, ALA425C, ALA456A, ALA456C, ARG479A, ARG479C, ASN426A, ASN426C, ASN452C, GLU484C, HIS480A, HIS480C, LEU481A, LEU481C, LYS424A, LYS424C, LYS478A, LYS478C, PRO453A, PRO453C, THR455A, THR455C, THR482A, THR482C, THR486A, THR486C, TYR454A, TYR454C, TYR457A, TYR457C
• A-D: ALA13D, ALA332A, ARG15D, ARG317A, ARG336A, ARG365A, ASN201A, ASN20D, ASN261A, ASN318A, ASP143D, ASP210A, ASP99A, CYS12D, CYS131D, CYS134D, CYS18D, GLN209A, GLU203A, GLU320A, GLY140D, GLY315A, HIS138D, HIS141D, HIS16D, HIS19D, HIS335A, ILE14D, ILE337A, LEU347A, LYS211A, PHE101A, PHE280A, PHE324A, PHE334A, PRO17D, PRO316A, PRO367A, SER135D, SER262A, SER331A, THR102A, THR11D, THR202A, THR204A, THR319A, THR322A, THR363A, TYR137D, TYR321A, VAL139D, VAL212A, VAL278A, VAL314A, VAL333A
• B-C: ALA13B, ALA332C, ARG15B, ARG317C, ARG336C, ARG365C, ASN201C, ASN20B, ASN318C, ASP143B, ASP210C, ASP99C, CYS12B, CYS18B, GLN209C, GLU203C, GLU320C, GLY140B, GLY315C, HIS138B, HIS141B, HIS16B, HIS19B, HIS335C, ILE14B, ILE337C, LEU130B, LEU22B, LEU323C, PHE101C, PHE280C, PHE324C, PHE334C, PRO17B, PRO316C, PRO367C, SER331C, THR102C, THR11B, THR202C, THR204C, THR319C, THR322C, VAL139B, VAL212C, VAL278C, VAL314C, VAL333C
• B-D: ALA10B, ALA10D, ALA13B, ALA13D, ARG123B, ARG123D, ARG15B, ARG15D, ARG99B, ARG99D, ASN105B, ASN105D, ASN96B, ASN96D, ASN9B, ASN9D, ASP100B, ASP100D, ASP143B, ASP143D, ASP149B, ASP149D, ASP154B, ASP154D, CYS12B, CYS12D, GLN101B, GLN101D, GLY140B, GLY140D, GLY147B, GLY147D, GLY152B, GLY152D, GLY95B, GLY95D, HIS138B, HIS138D, HIS141B, HIS141D, HIS16B, HIS16D, ILE103B, ILE103D, ILE14B, ILE14D, ILE5B, ILE5D, ILE97B, ILE97D, LEU104B, LEU104D, LEU126B, LEU3B, LEU3D, LEU94B, LEU94D, LYS102B, LYS102D, LYS153B, LYS153D, LYS158B, LYS158D, PHE156B, PHE156D, PRO106D, PRO148B, PRO148D, PRO17B, PRO17D, PRO2B, PRO2D, PRO4B, PRO4D, PRO7B, PRO7D, SER127B, SER127D, SER151B, SER151D, SER1B, SER1D, SER93B, SER93D, THR11B, THR11D, THR145B, THR145D, THR150B, THR150D, THR6B, THR6D, THR92B, THR92D, THR98B, THR98D, TYR146B, TYR146D, TYR84B, TYR84D, VAL139B, VAL139D, VAL142B, VAL142D, VAL144B, VAL144D, VAL155B, VAL155D, VAL88B, VAL88D, VAL8B, VAL8D
• C-D: ALA108D, ALA47D, ARG317C, ASN105D, ASN201C, ASN205C, ASN236C, ASN261C, ASN265C, ASN318C, ASN54D, ASN55D, ASN63D, ASP154D, ASP210C, ASP271C, ASP272C, ASP273C, ASP57D, CYS60D, GLN101D, GLN157D, GLN164D, GLN209C, GLN233C, GLN48D, GLU203C, GLU260C, GLU338C, GLU50D, GLY152D, GLY232C, GLY235C, GLY263C, GLY276C, GLY315C, GLY339C, GLY49D, GLY61D, HIS112D, ILE103D, ILE234C, ILE266C, ILE267C, ILE269C, ILE337C, LEU104D, LEU109D, LEU161D, LEU230C, LEU238C, LEU313C, LEU340C, LEU59D, LYS102D, LYS153D, LYS158D, LYS159D, LYS160D, LYS211C, LYS58D, PHE101C, PHE156D, PHE207C, PHE268C, PHE280C, PHE52D, PRO106D, PRO208C, PRO316C, PRO51D, PRO53D, SER107D, SER151D, SER1D, SER259C, SER262C, THR202C, THR204C, THR237C, THR264C, THR270C, THR277C, THR46D, TYR275C, TYR44D, TYR45D, VAL155D, VAL206C, VAL274C, VAL278C, VAL279C, VAL314C