2Q5D

crystal structure of human importin beta bound to the snurportin1 ibb-domain second crystal form

• Total interactions analyzed: 6
• Total true interactions: 4
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 201
  • Norm. En. per Res.: -2.8718
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-50.8061	-203.544	-322.891	-577.2411	201	15	3	16034	13	83	51
A-B	-46.3185	-109.3278	-142.351	-297.9972	142	83	1	10898	9	84	54
C-B	0.0	-2.9935	-0.0604	-3.0539	4	0	0	23	0	8	2
B-D	-5.9703	0.0	-59.2821	-65.2524	70	5	2	3297	0	53	27

Interface residues

• A-C: ALA347A, ALA348A, ALA428A, ALA429A, ALA467A, ALA473A, ALA586A, ALA62C, ALA631A, ALA669A, ALA670A, ALA680A, ALA721A, ALA723A, ALA768A, ALA816A, ALA819A, ALA858A, ALA865A, ARG27C, ARG425A, ARG434A, ARG43C, ARG44C, ARG45C, ARG465A, ARG46C, ARG525A, ARG55C, ARG593A, ARG63C, ARG64C, ARG679A, ASN285A, ASN343A, ASN469A, ASN522A, ASN523A, ASN578A, ASN590A, ASN60C, ASN856A, ASP288A, ASP334A, ASP337A, ASP338A, ASP339A, ASP340A, ASP341A, ASP384A, ASP426A, ASP579A, ASP57C, ASP627A, ASP676A, ASP719A, ASP779A, ASP824A, CYS287A, CYS345A, CYS351A, CYS392A, CYS471A, CYS585A, CYS678A, CYS817A, GLN239A, GLN278A, GLN30C, GLN333A, GLN40C, GLN51C, GLN581A, GLN589A, GLN665A, GLN682A, GLN712A, GLN774A, GLU281A, GLU289A, GLU395A, GLU39C, GLU42C, GLU437A, GLU479A, GLU530A, GLU534A, GLU626A, GLU637A, GLU760A, GLU763A, GLU767A, GLU868A, GLY349A, GLY433A, GLY672A, GLY675A, GLY718A, GLY725A, GLY771A, GLY775A, GLY778A, GLY813A, GLY820A, GLY823A, HIS61C, ILE280A, ILE713A, ILE720A, ILE724A, ILE822A, LEU277A, LEU28C, LEU330A, LEU354A, LEU438A, LEU47C, LEU48C, LEU50C, LEU56C, LEU580A, LEU583A, LEU584A, LEU629A, LEU668A, LEU673A, LEU677A, LEU681A, LEU714A, LEU722A, LEU821A, LEU825A, LEU861A, LYS32C, LYS346A, LYS34C, LYS52C, LYS537A, LYS54C, LYS777A, LYS857A, MET291A, MET353A, MET388A, MET533A, MET630A, PHE282A, PHE717A, PRO26C, PRO464A, PRO711A, SER246A, SER284A, SER29C, SER33C, SER41C, SER468A, SER475A, SER476A, SER526A, SER527A, SER53C, SER582A, SER633A, SER683A, SER715A, SER764A, THR357A, THR427A, THR431A, THR634A, THR770A, THR811A, THR827A, THR860A, THR863A, TRP283A, TRP342A, TRP430A, TRP472A, TRP864A, TYR31C, TYR35C, TYR58C, TYR664A, VAL242A, VAL286A, VAL350A, VAL422A, VAL423A, VAL424A, VAL466A, VAL470A, VAL59C, VAL636A, VAL638A, VAL666A, VAL671A, VAL674A, VAL716A, VAL773A
• A-B: ALA193B, ALA276B, ALA347B, ALA53B, ALA56B, ALA742A, ALA805A, ALA839A, ARG105B, ARG15B, ARG232B, ARG305A, ARG574B, ARG793A, ARG840A, ARG851A, ARG852A, ARG870A, ASN188B, ASN189B, ASN196B, ASN336B, ASN343B, ASN737A, ASN782A, ASN874A, ASP14B, ASP160B, ASP230B, ASP271B, ASP273B, ASP334B, ASP337B, ASP338B, ASP339B, ASP340B, ASP341B, ASP573B, ASP779A, ASP802A, GLN111B, GLN159B, GLN239B, GLN278B, GLN303A, GLN51B, GLN576B, GLN740A, GLN741A, GLN744A, GLN746A, GLN780A, GLN791A, GLN875A, GLU148B, GLU152B, GLU17B, GLU274B, GLU281B, GLU302A, GLU335B, GLU733A, GLU781A, GLU795A, GLU838A, GLU845A, GLU868A, GLU8B, GLY304A, GLY48B, GLY623B, GLY701A, GLY778A, GLY806A, HIS784A, HIS803A, HIS844A, ILE272B, ILE280B, ILE575B, ILE843A, LEU16B, LEU18B, LEU192B, LEU199B, LEU277B, LEU59B, LEU732A, LEU736A, LEU739A, LEU798A, LEU836A, LEU846A, LEU869A, LEU872A, LYS346B, LYS62B, LYS68B, LYS710A, LYS729A, LYS730A, LYS777A, LYS835A, LYS867A, LYS871A, LYS873A, LYS9B, MET842A, PHE577B, PHE796A, PHE800A, PRO106B, PRO13B, PRO229B, PRO344B, PRO785A, PRO792A, PRO841A, SER12B, SER572B, SER799A, THR103B, THR10B, THR231B, THR738A, THR848A, THR863A, THR866A, TRP342B, TRP864A, TYR104B, TYR156B, VAL11B, VAL123A, VAL190B, VAL233B, VAL235B, VAL275B, VAL52B, VAL55B, VAL734A, VAL783A
• C-B: ARG64C, ASN336B, ASP338B, GLN521B
• B-D: ALA586B, ALA62D, ALA631B, ALA669B, ALA680B, ALA723B, ALA768B, ARG43D, ARG44D, ARG45D, ARG46D, ARG55D, ARG593B, ARG63D, ARG64D, ARG679B, ASN60D, ASP57D, ASP627B, ASP676B, ASP719B, ASP824B, CYS678B, GLN51D, GLN589B, GLN665B, GLN682B, GLN712B, GLN774B, GLU42D, GLU530B, GLU637B, GLU763B, GLU767B, GLY672B, GLY675B, GLY718B, GLY771B, GLY823B, HIS61D, LEU47D, LEU48D, LEU50D, LEU56D, LEU583B, LEU639B, LEU673B, LEU677B, LEU681B, LEU722B, LEU861B, LYS52D, LYS54D, LYS857B, MET533B, MET630B, SER526B, SER53D, SER582B, SER633B, SER715B, THR634B, THR770B, THR827B, THR860B, TRP864B, TYR58D, VAL59D, VAL638B, VAL716B