2PZR

crystal strucure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k641r mutation responsible for pfeiffer syndrome

• Total interactions analyzed: 1
• Total true interactions: 1
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 114
  • Norm. En. per Res.: -3.5689
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-102.0642	-35.8823	-268.911	-406.8575	114	16	6	10326	11	68	73

Interface residues

• A-B: ALA523A, ALA523B, ALA628A, ALA628B, ALA674A, ALA674B, ARG478A, ARG478B, ARG573A, ARG573B, ARG630A, ARG630B, ARG664A, ARG664B, ARG678A, ARG678B, ASN662A, ASN662B, ASP521A, ASP521B, ASP522A, ASP522B, ASP527A, ASP527B, ASP557A, ASP557B, ASP626A, ASP626B, CYS554B, GLN556A, GLU467B, GLU525A, GLU525B, GLU710A, GLU710B, GLU711A, GLU711B, GLY558A, GLY558B, GLY663A, GLY663B, GLY701B, GLY706A, GLY706B, ILE707A, ILE707B, LEU468A, LEU468B, LEU519A, LEU519B, LEU528A, LEU528B, LEU531A, LEU531B, LEU560A, LEU560B, LEU647A, LEU647B, LEU665A, LEU665B, LEU675A, LEU675B, LEU712A, LEU712B, LYS520A, LYS520B, LYS526A, LYS526B, LYS659A, LYS659B, LYS668A, LYS668B, LYS714A, MET518A, MET518B, MET670A, MET670B, PHE676B, PHE713A, PHE713B, PRO559A, PRO559B, PRO666A, PRO666B, PRO703A, PRO703B, PRO705A, PRO705B, PRO708A, PRO708B, SER529A, SER529B, SER702A, SER702B, THR524A, THR524B, THR555A, THR555B, THR660A, THR660B, THR661A, THR661B, TRP669A, TRP669B, TYR561A, TYR561B, TYR704A, TYR704B, VAL532A, VAL532B, VAL667A, VAL667B, VAL709A, VAL709B