2PRG

ligand-binding domain of the human peroxisome proliferator activated receptor gamma

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 50
  • Norm. En. per Res.: -3.5126
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-16.468	-27.9356	-214.751	-259.1546	113	10	5	9677	2	42	37
A-C	-35.0485	-4.4433	-136.137	-175.6288	50	12	7	6718	0	5	7
B-C	-41.5501	-6.9612	-177.75	-226.2613	66	29	5	8176	1	22	22

Interface residues

• A-B: ALA376A, ALA416A, ALA416B, ALA433A, ALA433B, ARG397A, ARG397B, ARG443A, ARG443B, ASN412A, ASN412B, ASP396A, ASP396B, ASP408A, ASP408B, ASP411A, ASP411B, ASP441A, ASP441B, GLN410A, GLN410B, GLN415A, GLN415B, GLN430A, GLN430B, GLN437A, GLN437B, GLN444A, GLN444B, GLN451A, GLN451B, GLN454B, GLU324A, GLU324B, GLU369A, GLU369B, GLU407A, GLU407B, GLU418A, GLU418B, GLU448A, GLU448B, GLY395A, GLY395B, GLY399B, ILE391A, ILE391B, ILE445A, ILE445B, LEU211A, LEU211B, LEU377A, LEU393A, LEU393B, LEU400A, LEU400B, LEU413A, LEU413B, LEU414A, LEU414B, LEU417A, LEU417B, LEU419A, LEU419B, LEU431A, LEU431B, LEU435A, LEU435B, LEU436A, LEU436B, LEU442A, LEU442B, LEU476B, LYS373A, LYS373B, LYS404A, LYS404B, LYS422A, LYS422B, LYS434A, LYS434B, LYS438A, LYS438B, LYS458A, LYS458B, MET439A, MET439B, PHE370A, PHE387B, PHE432A, PHE432B, PRO398A, PRO398B, SER394A, SER394B, SER428A, SER428B, SER429A, SER429B, THR440A, THR440B, THR447A, THR447B, TYR320A, TYR320B, TYR477A, TYR477B, VAL390A, VAL390B, VAL403A, VAL403B, VAL446A, VAL446B
• A-C: ALA292A, ALA300A, ASN312A, ASP310A, ASP313A, ASP475A, GLN294A, GLN314A, GLN470A, GLN628C, GLN635C, GLU291A, GLU295A, GLU298A, GLU471A, HIS466A, HIS631C, ILE296A, ILE392A, ILE472A, LEU309A, LEU311A, LEU317A, LEU318A, LEU468A, LEU469A, LEU633C, LEU636C, LEU637C, LYS301A, LYS319A, LYS474A, LYS632C, PHE306A, PRO467A, SER630C, THR297A, THR316A, THR629C, THR638C, THR639C, THR640C, TYR320A, TYR473A, VAL290A, VAL293A, VAL307A, VAL315A, VAL322A, VAL634C
• B-C: ALA292B, ALA300B, ARG686C, ARG692C, ASN308B, ASN312B, ASP220B, ASP310B, ASP313B, ASP475B, ASP701C, GLN294B, GLN314B, GLN470B, GLN695C, GLU291B, GLU295B, GLU298B, GLU471B, GLU685C, GLU696C, GLY305B, GLY697C, HIS217B, HIS323B, HIS466B, HIS687C, HIS691C, ILE296B, ILE303B, ILE392B, ILE472B, ILE689C, ILE702C, LEU311B, LEU317B, LEU318B, LEU468B, LEU469B, LEU476B, LEU690C, LEU693C, LEU694C, LYS224B, LYS301B, LYS319B, LYS474B, LYS688C, PHE306B, PRO304B, PRO467B, PRO699C, SER221B, SER302B, SER698C, SER700C, THR297B, THR316B, TYR299B, TYR320B, TYR473B, VAL290B, VAL293B, VAL307B, VAL315B, VAL322B