2PPB

crystal structure of the t. thermophilus rnap polymerase elongation complex with the ntp substrate analog and antibiotic streptolydigin

• Total interactions analyzed: 120
• Total true interactions: 19
• Strongest Interaction:
  • Chains: M-N
  • Int. Res.: 765
  • Norm. En. per Res.: -3.8752
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-12.3058	2.1069	-385.305	-395.5039	142	48	16	17411	0	28	33
A-C	-73.694	-177.3763	-393.538	-644.6083	195	27	6	19313	13	119	103
A-D	0.0	3.2126	-1.0669	2.1458	8	0	0	140	0	7	5
B-C	-5.9562	-82.1026	-37.2771	-125.3359	34	2	0	1833	5	17	19
B-D	-12.9313	-77.6289	-217.686	-308.2462	126	15	9	10348	8	60	53
C-D	-365.0273	-239.9024	-2390.35	-2995.2798	776	284	77	103178	29	314	268
C-E	0.0	-30.0373	-22.292	-52.3293	29	3	0	967	1	10	8
D-E	-90.9427	-48.3565	-533.394	-672.6931	176	68	21	24831	9	69	57
D-M	-8.3208	10.6587	-50.3093	-47.9714	43	5	2	2495	0	21	14
D-N	-65.383	-30.2487	-493.353	-588.9846	202	123	3	19988	10	131	108
K-L	-5.4852	13.6413	-426.597	-418.4409	149	55	17	18427	0	29	34
K-M	-51.217	-143.956	-414.739	-609.912	196	33	7	20145	14	118	101
K-N	0.0	2.473	-0.7127	1.7603	8	0	0	113	0	7	5
L-M	-8.9467	-63.2513	-36.0526	-108.2507	33	0	0	1747	3	15	18
L-N	-18.0592	-108.7207	-199.264	-326.0439	127	19	8	9809	9	53	45
L-O	0.0	0.0	-0.0148	-0.0148	2	0	0	12	0	0	0
M-N	-323.5895	-310.2166	-2330.73	-2964.5361	765	269	81	102828	35	303	274
M-O	0.0	-23.055	-26.7391	-49.794	30	1	0	1326	0	11	10
N-O	-81.9688	-17.7964	-553.029	-652.7942	179	83	24	26333	3	73	58

Interface residues

• A-B: ALA214A, ALA214B, ALA8A, ALA8B, ARG14A, ARG14B, ARG189A, ARG189B, ARG219A, ARG219B, ARG30A, ARG30B, ARG41A, ARG41B, ARG42A, ARG42B, ASN212A, ASN212B, ASN227A, ASN227B, ASN38A, ASN38B, ASP191A, ASP193A, ASP193B, GLN188B, GLN229A, GLN229B, GLU154B, GLU216A, GLU216B, GLU220A, GLU220B, GLU26A, GLU26B, GLU29A, GLU29B, GLY149A, GLY149B, GLY157B, GLY31A, GLY31B, GLY33A, GLY33B, GLY37A, GLY37B, HIS156B, HIS221A, HIS221B, ILE217A, ILE217B, ILE43A, ILE43B, ILE48A, ILE48B, LEU195A, LEU195B, LEU197A, LEU197B, LEU208A, LEU208B, LEU211A, LEU211B, LEU218A, LEU218B, LEU222A, LEU222B, LEU25A, LEU25B, LEU28A, LEU28B, LEU36A, LEU36B, LEU40A, LEU40B, LEU44A, LEU44B, LEU45B, LEU6A, LEU6B, LYS155A, LYS155B, LYS5A, LYS5B, LYS7A, LYS7B, MET1A, PHE11A, PHE11B, PHE179A, PHE179B, PHE225A, PHE225B, PHE23A, PHE23B, PHE32A, PHE32B, PRO152B, PRO228A, PRO228B, PRO27A, PRO27B, PRO39A, PRO39B, PRO9A, PRO9B, SER226A, SER226B, SER46A, SER46B, SER47A, SER47B, SER4A, SER4B, THR12A, THR12B, THR15B, THR190A, THR196B, THR223A, THR223B, THR35A, THR35B, TYR150A, TYR150B, TYR224A, TYR224B, VAL10A, VAL10B, VAL13A, VAL13B, VAL148A, VAL148B, VAL151B, VAL181A, VAL181B, VAL215A, VAL215B, VAL24A, VAL24B, VAL34A, VAL34B
• A-C: ALA153A, ALA164A, ALA169A, ALA178A, ALA604C, ALA636C, ALA656C, ALA747C, ALA828C, ARG14A, ARG175A, ARG176A, ARG198A, ARG30A, ARG41A, ARG42A, ARG573C, ARG610C, ARG626C, ARG627C, ARG640C, ARG642C, ARG697C, ARG744C, ARG802C, ARG831C, ARG929C, ARG939C, ARG978C, ASN163A, ASN38A, ASN609C, ASN81A, ASP168A, ASP183A, ASP191A, ASP193A, ASP607C, ASP638C, ASP657C, ASP698C, ASP738C, ASP74A, ASP857C, ASP863C, ASP868C, ASP937C, ASP976C, GLN180A, GLN639C, GLN829C, GLU108A, GLU133A, GLU134A, GLU154A, GLU182A, GLU22A, GLU29A, GLU64A, GLU692C, GLU693C, GLU73A, GLU748C, GLU77A, GLU84A, GLU856C, GLU932C, GLU940C, GLU942C, GLU981C, GLY135A, GLY136A, GLY149A, GLY157A, GLY31A, GLY33A, GLY37A, GLY608C, GLY70A, GLY746C, GLY798C, GLY864C, GLY933C, GLY935C, GLY977C, GLY980C, HIS128A, HIS63A, HIS704C, HIS860C, ILE162A, ILE165A, ILE43A, ILE572C, ILE611C, ILE68A, ILE703C, ILE705C, ILE745C, ILE78A, ILE799C, ILE79A, ILE852C, LEU132A, LEU192A, LEU195A, LEU28A, LEU44A, LEU45A, LEU625C, LEU62A, LEU655C, LEU673C, LEU695C, LEU80A, LEU853C, LEU861C, LYS155A, LYS159A, LYS194A, LYS605C, LYS696C, LYS72A, LYS750C, LYS830C, LYS832C, LYS83A, LYS928C, LYS938C, MET858C, PHE171A, PHE179A, PHE23A, PHE32A, PHE628C, PHE65A, PHE896C, PHE926C, PHE934C, PRO106A, PRO152A, PRO166A, PRO39A, PRO641C, PRO69A, PRO854C, PRO859C, PRO862C, PRO866C, PRO982C, SER172A, SER46A, SER47A, SER66A, SER702C, THR131A, THR184A, THR190A, THR196A, THR35A, THR67A, THR701C, THR865C, THR979C, TRP200A, TYR150A, TYR20A, TYR629C, TYR895C, TYR975C, VAL148A, VAL151A, VAL167A, VAL170A, VAL174A, VAL177A, VAL181A, VAL24A, VAL34A, VAL606C, VAL612C, VAL61A, VAL643C, VAL644C, VAL645C, VAL71A, VAL75A, VAL76A, VAL800C, VAL801C, VAL827C, VAL855C, VAL867C, VAL936C, VAL941C
• A-D: ALA854D, ARG30A, GLY31A, GLY856D, HIS855D, ILE857D, LYS155A, LYS646D
• B-C: ARG30B, ARG41B, ARG42B, ARG939C, ARG978C, ASN38B, ASP183B, ASP191B, ASP193B, ASP857C, ASP976C, GLU29B, GLU692C, GLU856C, GLU981C, GLY31B, GLY977C, GLY980C, ILE852C, LEU695C, LEU853C, LYS696C, LYS851C, LYS938C, PHE179B, PHE32B, PRO39B, PRO854C, PRO982C, THR35B, THR979C, VAL181B, VAL34B, VAL855C
• B-D: ALA153B, ALA169B, ALA178B, ALA52B, ALA814D, ALA844D, ALA849D, ALA852D, ALA854D, ALA887D, ARG175B, ARG176B, ARG185B, ARG189B, ARG198B, ARG41B, ARG42B, ARG818D, ARG838D, ARG867D, ARG872D, ARG884D, ASN81B, ASN845D, ASP168B, ASP183B, ASP191B, ASP202B, ASP685D, ASP689D, ASP74B, ASP847D, GLN180B, GLN188B, GLN636D, GLU154B, GLU182B, GLU64B, GLU686D, GLU692D, GLU693D, GLU722D, GLU73B, GLU77B, GLU810D, GLU811D, GLU817D, GLU820D, GLU833D, GLU848D, GLU84B, GLU888D, GLU893D, GLY149B, GLY187B, GLY856D, HIS63B, HIS855D, ILE165B, ILE78B, ILE79B, ILE857D, ILE885D, LEU127B, LEU44B, LEU45B, LEU62B, LEU691D, LEU720D, LEU80B, LEU813D, LEU82B, LEU839D, LEU850D, LEU851D, LEU85B, LEU873D, LEU881D, LYS155B, LYS638D, LYS646D, LYS72B, LYS83B, LYS840D, LYS871D, PHE171B, PHE179B, PHE65B, PHE806D, PHE843D, PHE941D, PRO152B, PRO166B, PRO846D, SER172B, SER46B, SER47B, SER66B, THR190B, THR67B, THR834D, THR865D, TRP200B, TRP688D, TYR150B, TYR841D, TYR868D, TYR936D, TYR937D, VAL148B, VAL151B, VAL167B, VAL170B, VAL174B, VAL177B, VAL181B, VAL721D, VAL75B, VAL76B, VAL821D, VAL836D, VAL842D, VAL853D, VAL858D, VAL864D, VAL866D
• C-D: ALA1007C, ALA1024D, ALA1025C, ALA1028D, ALA1039C, ALA1042C, ALA1045C, ALA1046C, ALA1066C, ALA1069C, ALA1077D, ALA1082D, ALA1085D, ALA1089D, ALA1094C, ALA1096C, ALA1116C, ALA11D, ALA1220D, ALA1225D, ALA1226D, ALA13D, ALA1438D, ALA1450D, ALA1451D, ALA1474D, ALA380C, ALA447C, ALA497C, ALA499C, ALA515C, ALA516D, ALA555C, ALA558C, ALA649D, ALA672D, ALA673D, ALA675C, ALA687C, ALA705D, ALA715D, ALA732C, ALA733C, ALA735D, ALA738D, ALA746D, ALA747C, ALA755D, ALA757D, ALA759D, ALA840C, ALA850C, ALA854D, ALA909C, ALA947C, ALA954D, ARG1008C, ARG1029D, ARG1031C, ARG1036D, ARG1042D, ARG1058D, ARG1062D, ARG1063C, ARG1078D, ARG1086C, ARG1087D, ARG1096D, ARG1119C, ARG1239D, ARG1470D, ARG1482D, ARG189C, ARG19D, ARG331C, ARG350C, ARG353C, ARG35D, ARG388C, ARG422C, ARG428C, ARG432C, ARG437C, ARG48D, ARG512C, ARG516C, ARG525D, ARG534D, ARG557C, ARG601D, ARG613D, ARG615D, ARG622D, ARG628D, ARG647D, ARG65D, ARG674D, ARG675D, ARG679D, ARG681D, ARG6D, ARG704D, ARG710D, ARG713C, ARG735C, ARG744C, ARG760D, ARG783D, ARG791C, ARG796D, ARG831C, ARG86D, ARG879C, ARG87D, ARG89D, ARG939C, ARG945C, ARG946C, ARG978C, ARG9D, ASN1014D, ASN1018D, ASN1031D, ASN1064C, ASN1107C, ASN1465D, ASN448C, ASN500C, ASN507D, ASN556C, ASN617D, ASN669D, ASN683C, ASN703D, ASN737D, ASN768D, ASN845C, ASN872C, ASN881C, ASP1003C, ASP1058C, ASP1075C, ASP1083D, ASP1090D, ASP1098C, ASP1100D, ASP1103C, ASP1106C, ASP1110C, ASP1457D, ASP324C, ASP326C, ASP426C, ASP429C, ASP523D, ASP531D, ASP533C, ASP553C, ASP554C, ASP55D, ASP579D, ASP583D, ASP597D, ASP605D, ASP624D, ASP680C, ASP682D, ASP686C, ASP714C, ASP736C, ASP739D, ASP741D, ASP743D, ASP753C, ASP784D, ASP837C, ASP859D, ASP862D, ASP907C, ASP952D, ASP953D, ASP976C, CYS1039D, CYS439C, CYS58D, CYS733D, GLN1018C, GLN1019C, GLN1026C, GLN1030C, GLN1033D, GLN1034D, GLN1037D, GLN1046D, GLN1050C, GLN1093C, GLN1100C, GLN1227D, GLN498C, GLN529D, GLN538C, GLN611D, GLN616D, GLN636D, GLN66D, GLN680D, GLN714D, GLN724D, GLN727D, GLN744D, GLN756D, GLN762D, GLN794D, GLN834C, GLN861D, GLN884C, GLN969C, GLU1002C, GLU1034C, GLU1036C, GLU1041C, GLU1051C, GLU1051D, GLU1054D, GLU1061C, GLU1063D, GLU1068C, GLU1069D, GLU1074C, GLU1078C, GLU1083C, GLU1091C, GLU1104C, GLU1113C, GLU1219D, GLU122D, GLU1449D, GLU1458D, GLU1464D, GLU384C, GLU442C, GLU445C, GLU4D, GLU515D, GLU520C, GLU551C, GLU57D, GLU651D, GLU662D, GLU663D, GLU678D, GLU685C, GLU711C, GLU722D, GLU731C, GLU734D, GLU748C, GLU758D, GLU764C, GLU766C, GLU770C, GLU771C, GLU796C, GLU798D, GLU79D, GLU887C, GLU911C, GLU942C, GLU948C, GLU965C, GLU975D, GLU979D, GLU981C, GLU984C, GLY1011C, GLY1022C, GLY1027D, GLY1028C, GLY1029C, GLY1030D, GLY1033C, GLY1044C, GLY1050D, GLY1062C, GLY1064D, GLY1073C, GLY1076D, GLY1080D, GLY1081D, GLY1092D, GLY1114C, GLY1218D, GLY1222D, GLY1230D, GLY1454D, GLY1461D, GLY1469D, GLY1475D, GLY1477D, GLY24D, GLY424C, GLY436C, GLY446C, GLY450C, GLY519C, GLY51D, GLY532D, GLY533D, GLY595D, GLY612D, GLY620D, GLY627D, GLY634D, GLY681C, GLY70D, GLY712D, GLY723D, GLY742D, GLY752C, GLY763C, GLY77D, GLY788D, GLY795C, GLY797C, GLY818C, GLY836C, GLY844C, GLY847C, GLY856D, GLY875C, GLY883C, GLY91D, GLY938D, GLY946D, GLY950D, GLY951C, GLY956C, GLY970C, GLY985C, HIS1006C, HIS101D, HIS1047C, HIS1075D, HIS1103D, HIS1242D, HIS431C, HIS434C, HIS552C, HIS709D, HIS728C, HIS729D, HIS748D, HIS767D, HIS855D, HIS889C, HIS92D, HIS999C, ILE1016C, ILE102D, ILE1035D, ILE1060C, ILE1070C, ILE1071C, ILE1072D, ILE10D, ILE1111C, ILE1223D, ILE1452D, ILE1467D, ILE1472D, ILE18D, ILE438C, ILE449C, ILE452C, ILE496C, ILE513D, ILE523C, ILE53D, ILE547C, ILE606D, ILE631D, ILE676C, ILE683D, ILE688C, ILE713D, ILE726C, ILE726D, ILE754C, ILE785D, ILE786D, ILE792D, ILE827D, ILE84D, ILE852C, ILE857D, ILE870C, ILE885C, ILE905C, ILE914C, ILE93D, ILE947D, ILE949D, ILE951D, ILE956D, ILE983C, ILE987C, ILE9C, LEU1015C, LEU1020D, LEU1021C, LEU1038D, LEU1040C, LEU1049C, LEU1053C, LEU1055C, LEU1065D, LEU1068D, LEU1086D, LEU1088C, LEU1092C, LEU1094D, LEU1095C, LEU1097C, LEU1098D, LEU1102C, LEU1115C, LEU1209D, LEU12D, LEU1435D, LEU1447D, LEU1459D, LEU1462D, LEU1468D, LEU1471D, LEU328C, LEU37D, LEU451C, LEU514D, LEU520D, LEU524D, LEU540D, LEU550C, LEU559C, LEU581D, LEU582D, LEU603D, LEU607D, LEU618D, LEU619D, LEU637D, LEU644D, LEU650D, LEU652D, LEU657D, LEU658D, LEU677D, LEU701D, LEU702D, LEU708D, LEU711D, LEU728D, LEU729C, LEU731D, LEU734C, LEU737C, LEU751D, LEU755C, LEU764D, LEU774C, LEU787D, LEU790C, LEU823D, LEU839C, LEU860D, LEU871C, LEU874C, LEU882C, LEU886C, LEU890C, LEU918C, LEU950C, LEU952C, LEU966C, LEU968C, LEU971D, LEU972D, LEU974C, LEU997C, LYS1004C, LYS1024C, LYS1047D, LYS1056C, LYS1072C, LYS1079D, LYS1090C, LYS1097D, LYS1105C, LYS1118C, LYS1455D, LYS1456D, LYS1463D, LYS167C, LYS17D, LYS2D, LYS38D, LYS3D, LYS518C, LYS537C, LYS54D, LYS610D, LYS621D, LYS646D, LYS64D, LYS654D, LYS659D, LYS660D, LYS671D, LYS698D, LYS716C, LYS750C, LYS780D, LYS797D, LYS799D, LYS7D, LYS816C, LYS828D, LYS82D, LYS838C, LYS846C, LYS851C, LYS910C, LYS915C, LYS935D, LYS949C, LYS971C, MET1000C, MET1005C, MET1023D, MET1035C, MET1045D, MET1052C, MET1238D, MET512D, MET527D, MET560C, MET648D, MET677C, MET745D, MET763D, MET880C, MET90D, PHE1017D, PHE1027C, PHE1032C, PHE104D, PHE1053D, PHE1061D, PHE1071D, PHE1085C, PHE1112C, PHE1241D, PHE425C, PHE50D, PHE535D, PHE540C, PHE549C, PHE614D, PHE653D, PHE656D, PHE679C, PHE684C, PHE736D, PHE740D, PHE754D, PHE906C, PHE939D, PHE941D, PHE967C, PRO1012C, PRO1016D, PRO1019D, PRO1020C, PRO1048D, PRO1056D, PRO1077C, PRO1079C, PRO1082C, PRO1108C, PRO1473D, PRO15D, PRO440C, PRO444C, PRO518D, PRO521C, PRO521D, PRO522D, PRO526D, PRO52D, PRO536C, PRO594D, PRO635D, PRO645D, PRO655D, PRO678C, PRO706D, PRO730D, PRO750D, PRO751C, PRO767C, PRO769C, PRO772D, PRO781D, PRO793C, PRO794C, PRO817C, PRO826D, PRO859C, PRO873C, PRO877C, PRO877D, PRO912C, PRO955C, PRO982C, PRO986C, SER1009C, SER1014C, SER1026D, SER1049D, SER1057C, SER1059D, SER1060D, SER1073D, SER1074D, SER1080C, SER1084C, SER1091D, SER1117C, SER1210D, SER1439D, SER1478D, SER14D, SER20D, SER22D, SER535C, SER538D, SER596D, SER602D, SER626D, SER629D, SER725D, SER730C, SER752D, SER753D, SER765C, SER765D, SER782D, SER789C, SER83D, SER878C, SER942D, SER945D, THR1010C, THR1017C, THR1048C, THR1054C, THR1066D, THR1084D, THR1088D, THR1095D, THR1101C, THR1443D, THR1444D, THR1448D, THR1476D, THR36D, THR433C, THR443C, THR453C, THR501C, THR544C, THR604D, THR707D, THR715C, THR768C, THR81D, THR888C, THR940D, THR943D, THR944D, THR948D, THR979C, TRP1038C, TRP103D, TRP1434D, TRP21D, TRP511D, TYR1013C, TYR1015D, TYR1021D, TYR1043C, TYR1067C, TYR1070D, TYR1093D, TYR23D, TYR34D, TYR435C, TYR544D, TYR625D, TYR682C, TYR791D, TYR841D, TYR88D, TYR936D, TYR937D, VAL1001C, VAL1022D, VAL1037C, VAL1055D, VAL1057D, VAL1067D, VAL1076C, VAL1081C, VAL1087C, VAL1089C, VAL1099C, VAL1099D, VAL1106D, VAL1109C, VAL1221D, VAL1224D, VAL1466D, VAL427C, VAL430C, VAL441C, VAL514C, VAL517D, VAL519D, VAL522C, VAL528D, VAL530D, VAL539C, VAL578D, VAL5D, VAL623D, VAL630D, VAL632D, VAL633D, VAL670D, VAL689C, VAL694D, VAL700D, VAL721D, VAL72D, VAL732D, VAL743C, VAL747D, VAL749C, VAL749D, VAL78D, VAL792C, VAL80D, VAL819C, VAL835C, VAL848C, VAL849C, VAL853D, VAL858D, VAL85D, VAL863D, VAL876C, VAL8D, VAL943C, VAL955D, VAL972C, VAL988C, VAL989C
• C-E: ALA1042C, ALA1045C, ALA1046C, ALA24E, ALA27E, ALA60E, ARG18E, ARG32E, ASP1075C, GLN28E, GLN29E, GLU1041C, GLU1074C, GLU1078C, GLY1044C, GLY1073C, HIS1047C, LEU1040C, LEU30E, LEU31E, LYS16E, LYS25E, PRO1077C, THR1048C, THR20E, TYR1043C, TYR17E, VAL1076C, VAL21E
• D-E: ALA1212D, ALA1220D, ALA1474D, ALA1494D, ALA1498D, ALA1502D, ALA24E, ALA27E, ALA2E, ALA60E, ALA64E, ALA690D, ALA755D, ALA757D, ALA759D, ALA766D, ALA928D, ARG1213D, ARG1482D, ARG1499D, ARG18E, ARG26E, ARG32E, ARG710D, ARG72E, ARG760D, ARG84E, ARG91E, ARG929D, ASN37E, ASN59E, ASN768D, ASN78E, ASP1479D, ASP1488D, ASP14E, ASP57E, ASP689D, ASP7E, ASP83E, ASP932D, GLN1202D, GLN1485D, GLN1489D, GLN28E, GLN29E, GLN49E, GLN641D, GLN717D, GLN756D, GLN762D, GLN86E, GLU1219D, GLU1496D, GLU1497D, GLU1501D, GLU3E, GLU41E, GLU663D, GLU67E, GLU692D, GLU693D, GLU758D, GLU77E, GLU82E, GLU88E, GLU90E, GLU925D, GLY11E, GLY1218D, GLY1475D, GLY1477D, GLY53E, GLY5E, GLY697D, GLY71E, GLY76E, GLY923D, HIS33E, HIS640D, HIS696D, HIS767D, ILE1217D, ILE1495D, ILE695D, ILE6E, ILE761D, LEU1209D, LEU1492D, LEU19E, LEU30E, LEU31E, LEU40E, LEU51E, LEU54E, LEU639D, LEU68E, LEU69E, LEU73E, LEU764D, LEU769D, LEU79E, LEU85E, LEU922D, LEU92E, LEU931D, LEU9E, LYS1490D, LYS1493D, LYS1500D, LYS16E, LYS25E, LYS36E, LYS47E, LYS638D, LYS660D, LYS664D, LYS66E, LYS698D, LYS87E, LYS8E, LYS926D, MET1211D, MET12E, MET48E, MET65E, MET763D, MET89E, MET924D, PHE10E, PHE1480D, PHE1483D, PHE656D, PHE754D, PHE75E, PHE919D, PRO1214D, PRO46E, PRO4E, PRO58E, PRO81E, SER1210D, SER1216D, SER1478D, SER15E, SER752D, SER753D, SER765D, THR1476D, THR1484D, THR1491D, THR20E, THR38E, THR50E, THR62E, THR927D, TRP63E, TYR17E, TYR93E, VAL1107D, VAL1215D, VAL1221D, VAL1224D, VAL13E, VAL1481D, VAL1486D, VAL1487D, VAL21E, VAL22E, VAL23E, VAL39E, VAL61E, VAL694D, VAL699D, VAL74E, VAL80E
• D-M: ALA1409D, ALA370M, ARG1119M, ARG1282D, ARG1406D, ARG358M, ARG376M, ARG808M, ASN1404D, ASN374M, ASP1315D, ASP1317D, GLU1297D, GLU1405D, GLU1410D, GLU379M, GLU766M, GLY1298D, GLY1316D, GLY1411D, GLY362M, HIS483D, ILE1408D, LEU115M, LEU1403D, LEU1407D, LEU351M, LEU367M, LEU372M, LYS1314D, LYS1412D, LYS371M, MET361M, PHE114M, PRO1414D, PRO369M, PRO377M, SER363M, SER366M, SER375M, THR1413D, VAL113M, VAL373M
• D-N: ALA1150D, ALA1177D, ALA1180D, ALA1321D, ALA1338D, ALA1416D, ALA559N, ALA562N, ALA59N, ARG1151D, ARG1159D, ARG1164D, ARG1282D, ARG159N, ARG162N, ARG206N, ARG35N, ARG414N, ARG41N, ARG434N, ARG441N, ARG48N, ARG553N, ARG75N, ARG832D, ARG838D, ARG86N, ARG872D, ARG89N, ARG921D, ASN33N, ASN442N, ASP1169D, ASP1170D, ASP1278D, ASP1315D, ASP1317D, ASP1383D, ASP181N, ASP405N, ASP406N, ASP413N, ASP423N, ASP42N, ASP46N, ASP55N, ASP903D, CYS58N, CYS60N, CYS73N, CYS76N, GLN1184D, GLN1323D, GLN166N, GLN560N, GLN901D, GLN917D, GLU1152D, GLU1154D, GLU1161D, GLU1179D, GLU1182D, GLU1185D, GLU1276D, GLU1284D, GLU1285D, GLU1287D, GLU1288D, GLU1295D, GLU1297D, GLU1302D, GLU1320D, GLU1337D, GLU25N, GLU27N, GLU30N, GLU404N, GLU40N, GLU436N, GLU47N, GLU564N, GLU57N, GLU74N, GLU79N, GLU833D, GLU874D, GLU898D, GLY1157D, GLY1181D, GLY1279D, GLY1298D, GLY1316D, GLY24N, GLY412N, GLY43N, GLY51N, GLY561N, GLY61N, GLY77N, ILE1118D, ILE1183D, ILE1277D, ILE1283D, ILE49N, ILE53N, ILE565N, ILE566N, ILE567N, ILE84N, LEU1122D, LEU1144D, LEU1149D, LEU1156D, LEU1160D, LEU1173D, LEU1174D, LEU1290D, LEU1305D, LEU1311D, LEU1325D, LEU394N, LEU439N, LEU557N, LEU558N, LEU873D, LEU899D, LEU902D, LEU920D, LYS1176D, LYS1289D, LYS1301D, LYS1304D, LYS1314D, LYS1339D, LYS1418D, LYS28N, LYS38N, LYS54N, LYS555N, LYS556N, LYS62N, LYS71N, LYS82N, LYS871D, LYS894D, PHE1123D, PHE1293D, PHE1299D, PHE207N, PHE403N, PHE45N, PHE50N, PRO1121D, PRO1187D, PRO39N, PRO402N, PRO52N, PRO563N, SER1119D, SER1167D, SER1291D, SER1296D, SER1300D, SER410N, SER83N, THR1286D, THR1382D, THR168N, THR36N, THR411N, THR81N, TRP1417D, TRP897D, TYR1117D, TYR1303D, TYR1318D, TYR158N, TYR163N, TYR205N, TYR23N, TYR34N, TYR63N, VAL1120D, VAL1153D, VAL1155D, VAL1158D, VAL1186D, VAL1188D, VAL1280D, VAL1281D, VAL1292D, VAL1294D, VAL1319D, VAL26N, VAL435N, VAL437N, VAL440N, VAL443N, VAL72N, VAL78N, VAL80N, VAL85N
• K-L: ALA214K, ALA214L, ALA8K, ALA8L, ARG14K, ARG14L, ARG189K, ARG189L, ARG219K, ARG219L, ARG30K, ARG30L, ARG41K, ARG41L, ARG42K, ARG42L, ASN212K, ASN212L, ASN227K, ASN227L, ASN38K, ASN38L, ASP191K, ASP191L, ASP193K, ASP193L, GLN188L, GLN213L, GLN229K, GLN229L, GLU154L, GLU216K, GLU216L, GLU220K, GLU220L, GLU26K, GLU26L, GLU29K, GLU29L, GLY149K, GLY149L, GLY157L, GLY31K, GLY31L, GLY33K, GLY33L, GLY37K, GLY37L, HIS156L, HIS221K, HIS221L, ILE158L, ILE199L, ILE217K, ILE217L, ILE43K, ILE43L, ILE48K, ILE48L, LEU195K, LEU195L, LEU197K, LEU197L, LEU208K, LEU208L, LEU211K, LEU211L, LEU218K, LEU218L, LEU222K, LEU222L, LEU25K, LEU25L, LEU28K, LEU28L, LEU36K, LEU36L, LEU40K, LEU40L, LEU44K, LEU44L, LEU45K, LEU45L, LEU6K, LEU6L, LYS155K, LYS155L, LYS5K, LYS5L, LYS7K, LYS7L, MET1K, PHE11K, PHE11L, PHE179L, PHE225K, PHE225L, PHE23K, PHE23L, PHE32K, PHE32L, PRO152K, PRO152L, PRO228K, PRO228L, PRO27K, PRO27L, PRO39K, PRO39L, PRO9K, PRO9L, SER226K, SER226L, SER46K, SER46L, SER47K, SER47L, SER4K, SER4L, THR12K, THR12L, THR15K, THR15L, THR190K, THR190L, THR196L, THR223K, THR223L, THR35K, THR35L, TYR150K, TYR150L, TYR224K, TYR224L, VAL10K, VAL10L, VAL13K, VAL13L, VAL148K, VAL148L, VAL151K, VAL151L, VAL181L, VAL215K, VAL215L, VAL24K, VAL24L, VAL34K, VAL34L
• K-M: ALA153K, ALA164K, ALA169K, ALA178K, ALA604M, ALA636M, ALA747M, ALA828M, ARG14K, ARG175K, ARG176K, ARG198K, ARG30K, ARG41K, ARG42K, ARG573M, ARG610M, ARG627M, ARG640M, ARG642M, ARG697M, ARG744M, ARG802M, ARG831M, ARG929M, ARG939M, ARG978M, ASN163K, ASN38K, ASN609M, ASN81K, ASP168K, ASP183K, ASP191K, ASP193K, ASP607M, ASP638M, ASP698M, ASP738M, ASP74K, ASP857M, ASP863M, ASP868M, ASP937M, ASP976M, GLN180K, GLN639M, GLN647M, GLN829M, GLU108K, GLU133K, GLU134K, GLU154K, GLU182K, GLU22K, GLU26K, GLU29K, GLU64K, GLU692M, GLU693M, GLU73K, GLU748M, GLU77K, GLU796M, GLU84K, GLU856M, GLU932M, GLU940M, GLU981M, GLY149K, GLY157K, GLY31K, GLY33K, GLY37K, GLY608M, GLY646M, GLY70K, GLY746M, GLY798M, GLY864M, GLY931M, GLY933M, GLY935M, GLY977M, GLY980M, HIS156K, HIS63K, HIS704M, HIS860M, ILE162K, ILE165K, ILE199K, ILE43K, ILE572M, ILE611M, ILE68K, ILE703M, ILE705M, ILE745M, ILE78K, ILE799M, ILE79K, ILE852M, LEU132K, LEU192K, LEU195K, LEU28K, LEU44K, LEU45K, LEU625M, LEU62K, LEU655M, LEU673M, LEU694M, LEU695M, LEU80K, LEU833M, LEU853M, LEU861M, LYS155K, LYS159K, LYS194K, LYS605M, LYS696M, LYS72K, LYS750M, LYS830M, LYS832M, LYS83K, LYS928M, LYS930M, LYS938M, MET858M, PHE171K, PHE179K, PHE23K, PHE32K, PHE628M, PHE65K, PHE699M, PHE896M, PHE926M, PHE934M, PRO106K, PRO152K, PRO166K, PRO39K, PRO641M, PRO69K, PRO854M, PRO862M, PRO866M, PRO982M, SER172K, SER46K, SER47K, SER66K, THR131K, THR184K, THR190K, THR196K, THR35K, THR67K, THR701M, THR865M, THR979M, TRP200K, TYR150K, TYR20K, TYR895M, TYR925M, TYR975M, VAL151K, VAL167K, VAL170K, VAL174K, VAL177K, VAL181K, VAL24K, VAL34K, VAL603M, VAL606M, VAL612M, VAL61K, VAL643M, VAL644M, VAL645M, VAL71K, VAL75K, VAL76K, VAL800M, VAL801M, VAL827M, VAL855M, VAL936M, VAL941M
• K-N: ARG30K, GLU722N, GLY31K, GLY856N, HIS855N, ILE857N, LYS155K, PHE32K
• L-M: ARG30L, ARG41L, ARG42L, ARG939M, ARG978M, ASN38L, ASP183L, ASP191L, ASP193L, ASP857M, ASP976M, GLU29L, GLU692M, GLU856M, GLU981M, GLY31L, GLY977M, GLY980M, ILE852M, LEU695M, LEU853M, LYS696M, LYS851M, PHE179L, PHE32L, PRO39L, PRO854M, THR35L, THR979M, TYR682M, VAL181L, VAL34L, VAL855M
• L-N: ALA153L, ALA169L, ALA178L, ALA690N, ALA844N, ALA849N, ALA852N, ALA854N, ALA887N, ARG175L, ARG176L, ARG185L, ARG189L, ARG198L, ARG41L, ARG42L, ARG838N, ARG867N, ARG872N, ARG884N, ASN81L, ASN845N, ASP168L, ASP183L, ASP191L, ASP202L, ASP685N, ASP689N, ASP74L, ASP847N, GLN180L, GLN188L, GLN636N, GLU154L, GLU182L, GLU64L, GLU686N, GLU692N, GLU693N, GLU722N, GLU73L, GLU77L, GLU810N, GLU817N, GLU820N, GLU833N, GLU848N, GLU84L, GLU888N, GLU891N, GLY149L, GLY187L, GLY856N, GLY870N, HIS128L, HIS63L, HIS855N, ILE43L, ILE78L, ILE79L, ILE857N, ILE885N, LEU127L, LEU44L, LEU45L, LEU62L, LEU691N, LEU720N, LEU80L, LEU813N, LEU82L, LEU839N, LEU850N, LEU851N, LEU85L, LEU873N, LEU881N, LYS155L, LYS194L, LYS638N, LYS646N, LYS72L, LYS83L, LYS840N, LYS871N, PHE171L, PHE179L, PHE65L, PHE806N, PHE843N, PRO152L, PRO846N, SER172L, SER46L, SER47L, SER66L, THR190L, THR196L, THR67L, THR834N, THR865N, THR944N, TRP200L, TRP688N, TYR150L, TYR841N, TYR868N, TYR936N, TYR937N, VAL148L, VAL151L, VAL167L, VAL170L, VAL174L, VAL177L, VAL181L, VAL687N, VAL719N, VAL721N, VAL75L, VAL76L, VAL821N, VAL836N, VAL842N, VAL853N, VAL858N, VAL866N
• L-O: ARG185L, THR50O
• M-N: ALA1007M, ALA1024N, ALA1025M, ALA1028N, ALA1039M, ALA1042M, ALA1045M, ALA1046M, ALA1066M, ALA1069M, ALA1077N, ALA1082N, ALA1085N, ALA1089N, ALA1094M, ALA1096M, ALA1116M, ALA11N, ALA1220N, ALA1225N, ALA1226N, ALA13N, ALA1438N, ALA1450N, ALA1451N, ALA1474N, ALA380M, ALA447M, ALA456M, ALA497M, ALA499M, ALA515M, ALA516N, ALA555M, ALA558M, ALA59N, ALA649N, ALA673N, ALA675M, ALA687M, ALA705N, ALA715N, ALA732M, ALA733M, ALA735N, ALA738N, ALA746N, ALA747M, ALA755N, ALA757N, ALA759N, ALA840M, ALA850M, ALA854N, ALA909M, ALA947M, ALA954N, ARG1008M, ARG1029N, ARG1031M, ARG1036N, ARG1042N, ARG1058N, ARG1062N, ARG1063M, ARG1078N, ARG1086M, ARG1087N, ARG1096N, ARG1119M, ARG1470N, ARG1482N, ARG19N, ARG350M, ARG353M, ARG35N, ARG383M, ARG388M, ARG422M, ARG428M, ARG432M, ARG437M, ARG512M, ARG516M, ARG525N, ARG534N, ARG557M, ARG601N, ARG613N, ARG615N, ARG622N, ARG628N, ARG647N, ARG65N, ARG674N, ARG675N, ARG679N, ARG681N, ARG6N, ARG704N, ARG710N, ARG713M, ARG735M, ARG744M, ARG760N, ARG783N, ARG791M, ARG796N, ARG831M, ARG86N, ARG879M, ARG87N, ARG89N, ARG945M, ARG946M, ARG978M, ARG9N, ASN1014N, ASN1018N, ASN1031N, ASN1064M, ASN1107M, ASN130M, ASN1465N, ASN500M, ASN507N, ASN556M, ASN617N, ASN669N, ASN683M, ASN703N, ASN737N, ASN768N, ASN845M, ASN872M, ASN881M, ASP1003M, ASP1058M, ASP1059M, ASP1075M, ASP1083N, ASP1098M, ASP1100N, ASP1103M, ASP1106M, ASP1110M, ASP1457N, ASP324M, ASP326M, ASP426M, ASP429M, ASP523N, ASP531N, ASP533M, ASP553M, ASP554M, ASP55N, ASP583N, ASP624N, ASP680M, ASP682N, ASP686M, ASP714M, ASP736M, ASP739N, ASP741N, ASP743N, ASP753M, ASP784N, ASP787M, ASP837M, ASP859N, ASP862N, ASP907M, ASP952N, ASP953N, ASP976M, CYS1039N, CYS439M, CYS58N, CYS733N, GLN1018M, GLN1019M, GLN1026M, GLN1030M, GLN1033N, GLN1034N, GLN1037N, GLN1046N, GLN1050M, GLN1093M, GLN1100M, GLN1227N, GLN498M, GLN529N, GLN538M, GLN611N, GLN616N, GLN636N, GLN680N, GLN714N, GLN724N, GLN727N, GLN744N, GLN756N, GLN762N, GLN834M, GLN861N, GLN884M, GLN969M, GLU1002M, GLU1034M, GLU1036M, GLU1041M, GLU1051M, GLU1051N, GLU1054N, GLU1061M, GLU1063N, GLU1068M, GLU1069N, GLU1074M, GLU1078M, GLU1083M, GLU1091M, GLU1104M, GLU1113M, GLU1219N, GLU1449N, GLU1458N, GLU384M, GLU442M, GLU445M, GLU4N, GLU515N, GLU520M, GLU551M, GLU57N, GLU651N, GLU662N, GLU663N, GLU678N, GLU685M, GLU711M, GLU722N, GLU734N, GLU748M, GLU758N, GLU764M, GLU766M, GLU770M, GLU771M, GLU796M, GLU798N, GLU79N, GLU820N, GLU887M, GLU911M, GLU942M, GLU948M, GLU965M, GLU975N, GLU981M, GLU984M, GLY1011M, GLY1022M, GLY1027N, GLY1028M, GLY1029M, GLY1030N, GLY1033M, GLY1044M, GLY1050N, GLY1062M, GLY1064N, GLY1073M, GLY1076N, GLY1080N, GLY1081N, GLY1092N, GLY1114M, GLY1218N, GLY1222N, GLY1230N, GLY1454N, GLY1461N, GLY1469N, GLY1475N, GLY1477N, GLY24N, GLY424M, GLY436M, GLY446M, GLY450M, GLY519M, GLY532N, GLY533N, GLY595N, GLY612N, GLY61N, GLY620N, GLY627N, GLY634N, GLY681M, GLY70N, GLY712N, GLY723N, GLY742N, GLY752M, GLY763M, GLY77N, GLY788N, GLY795M, GLY797M, GLY818M, GLY836M, GLY844M, GLY847M, GLY856N, GLY875M, GLY883M, GLY91N, GLY938N, GLY946N, GLY950N, GLY951M, GLY956M, GLY970M, GLY985M, HIS1006M, HIS101N, HIS1047M, HIS1075N, HIS1103N, HIS431M, HIS434M, HIS552M, HIS709N, HIS728M, HIS729N, HIS748N, HIS767N, HIS855N, HIS889M, HIS92N, HIS999M, ILE1016M, ILE102N, ILE1035N, ILE1060M, ILE1070M, ILE1071M, ILE1072N, ILE10N, ILE1111M, ILE1223N, ILE1452N, ILE1467N, ILE1472N, ILE18N, ILE438M, ILE449M, ILE452M, ILE496M, ILE513N, ILE523M, ILE53N, ILE547M, ILE606N, ILE631N, ILE676M, ILE683N, ILE688M, ILE713N, ILE726M, ILE726N, ILE754M, ILE761N, ILE785N, ILE786N, ILE792N, ILE827N, ILE84N, ILE852M, ILE857N, ILE870M, ILE885M, ILE905M, ILE914M, ILE947N, ILE949N, ILE951N, ILE956N, ILE983M, ILE987M, ILE9M, LEU1015M, LEU1020N, LEU1021M, LEU1038N, LEU1040M, LEU1049M, LEU1053M, LEU1055M, LEU1065N, LEU1068N, LEU1086N, LEU1088M, LEU1092M, LEU1094N, LEU1095M, LEU1097M, LEU1098N, LEU1102M, LEU1115M, LEU1209N, LEU12N, LEU1435N, LEU1447N, LEU1459N, LEU1462N, LEU1468N, LEU1471N, LEU328M, LEU37N, LEU451M, LEU514N, LEU520N, LEU524N, LEU540N, LEU550M, LEU559M, LEU581N, LEU582N, LEU603N, LEU607N, LEU618N, LEU619N, LEU637N, LEU644N, LEU650N, LEU652N, LEU657N, LEU658N, LEU677N, LEU701N, LEU702N, LEU708N, LEU711N, LEU728N, LEU729M, LEU731N, LEU734M, LEU751N, LEU755M, LEU764N, LEU769N, LEU774M, LEU787N, LEU823N, LEU839M, LEU860N, LEU871M, LEU874M, LEU882M, LEU886M, LEU890M, LEU918M, LEU950M, LEU952M, LEU966M, LEU968M, LEU972N, LEU974M, LEU997M, LYS1004M, LYS1047N, LYS1056M, LYS1072M, LYS1079N, LYS1090M, LYS1097N, LYS1105M, LYS1118M, LYS1455N, LYS1456N, LYS1463N, LYS17N, LYS2N, LYS38N, LYS3N, LYS518M, LYS537M, LYS54N, LYS610N, LYS621N, LYS646N, LYS64N, LYS654N, LYS659N, LYS660N, LYS671N, LYS698N, LYS716M, LYS71N, LYS750M, LYS780N, LYS797N, LYS799N, LYS7N, LYS816M, LYS828N, LYS82N, LYS838M, LYS840N, LYS846M, LYS851M, LYS910M, LYS915M, LYS935N, LYS949M, LYS971M, MET1000M, MET1005M, MET1023N, MET1035M, MET1045N, MET1052M, MET512N, MET527N, MET560M, MET648N, MET676N, MET677M, MET745N, MET763N, MET880M, MET90N, PHE1017N, PHE1027M, PHE1032M, PHE104N, PHE1053N, PHE1061N, PHE1071N, PHE1085M, PHE1112M, PHE1241N, PHE1440N, PHE425M, PHE535N, PHE540M, PHE549M, PHE614N, PHE653N, PHE656N, PHE679M, PHE684M, PHE736N, PHE740N, PHE754N, PHE906M, PHE939N, PHE941N, PRO1012M, PRO1016N, PRO1019N, PRO1020M, PRO1048N, PRO1056N, PRO1077M, PRO1079M, PRO1082M, PRO1108M, PRO1473N, PRO15N, PRO440M, PRO444M, PRO518N, PRO521M, PRO521N, PRO522N, PRO526N, PRO52N, PRO536M, PRO594N, PRO635N, PRO645N, PRO655N, PRO678M, PRO706N, PRO730N, PRO750N, PRO751M, PRO767M, PRO769M, PRO772N, PRO781N, PRO793M, PRO794M, PRO817M, PRO826N, PRO859M, PRO873M, PRO877M, PRO912M, PRO955M, PRO982M, PRO986M, SER1009M, SER1014M, SER1026N, SER1049N, SER1057M, SER1059N, SER1060N, SER1073N, SER1074N, SER1080M, SER1084M, SER1091N, SER1117M, SER1210N, SER1216N, SER1228N, SER1439N, SER1478N, SER14N, SER20N, SER22N, SER454M, SER535M, SER538N, SER596N, SER602N, SER626N, SER629N, SER725N, SER730M, SER752N, SER753N, SER765M, SER765N, SER782N, SER789M, SER83N, SER878M, SER942N, SER945N, THR1010M, THR1017M, THR1048M, THR1052N, THR1054M, THR1066N, THR1084N, THR1088N, THR1095N, THR1101M, THR1234N, THR1443N, THR1444N, THR1448N, THR1476N, THR36N, THR433M, THR443M, THR453M, THR501M, THR544M, THR604N, THR707N, THR715M, THR768M, THR81N, THR888M, THR940N, THR943N, THR944N, THR948N, THR979M, TRP1038M, TRP103N, TRP1434N, TRP21N, TRP511N, TYR1013M, TYR1015N, TYR1021N, TYR1043M, TYR1067M, TYR1070N, TYR1093N, TYR23N, TYR34N, TYR435M, TYR471M, TYR544N, TYR625N, TYR682M, TYR791N, TYR841N, TYR88N, TYR936N, TYR937N, TYR989N, VAL1001M, VAL1022N, VAL1037M, VAL1055N, VAL1057N, VAL1067N, VAL1076M, VAL1081M, VAL1087M, VAL1089M, VAL1099M, VAL1099N, VAL1106N, VAL1109M, VAL1221N, VAL1224N, VAL1466N, VAL1481N, VAL427M, VAL430M, VAL441M, VAL514M, VAL517N, VAL519N, VAL522M, VAL528N, VAL530N, VAL539M, VAL5N, VAL623N, VAL630N, VAL632N, VAL633N, VAL670N, VAL689M, VAL694N, VAL721N, VAL72N, VAL732N, VAL747N, VAL749M, VAL749N, VAL78N, VAL792M, VAL80N, VAL819M, VAL835M, VAL848M, VAL849M, VAL853N, VAL858N, VAL85N, VAL876M, VAL8N, VAL943M, VAL955N, VAL972M, VAL988M, VAL989M
• M-O: ALA1042M, ALA1045M, ALA1046M, ALA24O, ALA27O, ALA60O, ARG18O, ARG32O, ASP1075M, GLN28O, GLN29O, GLU1041M, GLU1074M, GLU1078M, GLY1044M, GLY1073M, HIS1047M, LEU30O, LEU31O, LYS1072M, LYS16O, LYS25O, PHE35O, PRO1077M, THR1048M, THR20O, TYR1043M, TYR17O, VAL1076M, VAL21O
• N-O: ALA1212N, ALA1220N, ALA1474N, ALA1494N, ALA1498N, ALA1502N, ALA24O, ALA27O, ALA2O, ALA60O, ALA64O, ALA690N, ALA755N, ALA757N, ALA759N, ALA766N, ALA928N, ARG1213N, ARG1482N, ARG1499N, ARG18O, ARG26O, ARG710N, ARG72O, ARG760N, ARG84O, ARG91O, ARG929N, ASN37O, ASN59O, ASN768N, ASN78O, ASP1479N, ASP1488N, ASP14O, ASP56O, ASP57O, ASP689N, ASP7O, ASP83O, ASP932N, GLN1202N, GLN1485N, GLN1489N, GLN28O, GLN29O, GLN49O, GLN641N, GLN717N, GLN756N, GLN762N, GLN86O, GLU1219N, GLU1496N, GLU1497N, GLU1501N, GLU3O, GLU41O, GLU663N, GLU67O, GLU692N, GLU693N, GLU758N, GLU77O, GLU82O, GLU88O, GLU90O, GLU925N, GLY11O, GLY1218N, GLY1475N, GLY1477N, GLY53O, GLY5O, GLY697N, GLY71O, GLY76O, GLY923N, HIS33O, HIS640N, HIS696N, HIS767N, ILE1217N, ILE1495N, ILE695N, ILE6O, ILE761N, LEU1209N, LEU1471N, LEU1492N, LEU19O, LEU30O, LEU31O, LEU40O, LEU51O, LEU54O, LEU639N, LEU68O, LEU691N, LEU69O, LEU73O, LEU764N, LEU769N, LEU79O, LEU85O, LEU922N, LEU92O, LEU931N, LEU9O, LYS1490N, LYS1493N, LYS1500N, LYS16O, LYS25O, LYS36O, LYS47O, LYS638N, LYS660N, LYS664N, LYS698N, LYS87O, LYS8O, LYS926N, MET1211N, MET12O, MET48O, MET65O, MET763N, MET89O, MET924N, PHE10O, PHE1480N, PHE1483N, PHE35O, PHE656N, PHE754N, PHE75O, PHE919N, PRO1214N, PRO46O, PRO4O, PRO58O, PRO81O, SER1210N, SER1216N, SER1478N, SER15O, SER752N, SER753N, SER765N, THR1476N, THR1484N, THR1491N, THR20O, THR38O, THR50O, THR62O, THR927N, TRP63O, TYR17O, TYR93O, VAL1106N, VAL1107N, VAL1215N, VAL1221N, VAL1224N, VAL13O, VAL1481N, VAL1486N, VAL1487N, VAL21O, VAL22O, VAL23O, VAL39O, VAL61O, VAL694N, VAL699N, VAL74O, VAL80O