2PGW

crystal structure of a putative muconate cycloisomerase from sinorhizobium meliloti 1021

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: C-F
  • Int. Res.: 121
  • Norm. En. per Res.: -3.3935
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-49.7062	-47.3708	-317.433	-414.51	123	12	17	11792	4	22	40
A-E	-53.7374	-46.0892	-146.531	-246.3576	74	8	2	6368	6	48	44
A-F	-58.274	-44.9657	-147.398	-250.6377	74	7	2	6380	5	47	45
A-G	-2.1146	4.3754	-495.693	-493.4322	165	11	8	18214	2	30	23
B-C	-51.5908	-47.5878	-151.229	-250.4076	75	7	2	6506	6	49	45
B-F	-2.8454	5.2555	-497.794	-495.3839	158	11	8	18074	2	30	23
B-G	-33.3851	-44.631	-147.07	-225.0861	74	10	2	6583	7	49	44
C-D	-49.1041	-50.259	-147.246	-246.6091	75	8	2	6441	5	48	44
C-F	-46.864	-45.1221	-318.633	-410.6191	121	11	17	11851	4	21	41
C-H	-8.265	9.8749	-490.996	-489.3861	159	7	8	18115	2	30	24
D-E	-2.8063	5.2023	-480.814	-478.4179	158	13	8	17972	2	31	23
D-G	-57.404	-43.1009	-148.678	-249.183	75	9	2	6468	5	47	45
D-H	-53.158	-46.1447	-319.771	-419.0737	124	9	18	11876	4	22	40
E-G	-43.538	-46.0535	-315.233	-404.8246	122	9	17	11876	4	22	41
E-H	-49.4841	-40.8673	-146.769	-237.1204	75	8	2	6461	5	47	44
F-H	-52.2131	-47.0901	-142.002	-241.3052	74	9	2	6362	5	48	44

Interface residues

• A-B: ALA121A, ALA121B, ALA132A, ALA132B, ALA284A, ALA284B, ALA285A, ALA285B, ALA286A, ALA286B, ALA288A, ALA288B, ALA290A, ALA290B, ALA291A, ALA291B, ALA316A, ALA316B, ALA80A, ALA80B, ALA84A, ALA84B, ARG134A, ARG134B, ARG261A, ARG261B, ARG263A, ARG263B, ARG352A, ARG352B, ARG85A, ARG85B, ASN319A, ASN319B, ASP110A, ASP110B, ASP255A, ASP255B, ASP78A, ASP78B, CYS260A, CYS260B, GLN117A, GLN117B, GLN127A, GLN127B, GLN262A, GLN262B, GLN279A, GLN279B, GLU258A, GLU258B, GLU289A, GLU289B, GLY130A, GLY130B, GLY131A, GLY131B, GLY292A, GLY292B, HIS126A, HIS126B, HIS133A, HIS133B, HIS74A, HIS77A, HIS77B, ILE259A, ILE259B, ILE275A, ILE275B, ILE317A, ILE317B, ILE83A, ILE83B, LEU120A, LEU120B, LEU123A, LEU123B, LEU128A, LEU128B, LEU129A, LEU129B, LEU253A, LEU253B, LEU293A, LEU293B, LEU315A, LEU315B, LEU82A, LEU82B, LYS135B, LYS283A, LYS283B, LYS5B, PRO124A, PRO124B, PRO280A, PRO280B, PRO318A, PRO318B, PRO76A, PRO76B, PRO81A, PRO81B, SER75A, SER75B, THR252A, THR252B, TRP114A, TRP114B, TYR254A, TYR254B, TYR257A, TYR257B, VAL256A, VAL256B, VAL287A, VAL287B, VAL4A, VAL4B, VAL79A, VAL79B
• A-E: ALA191E, ALA206A, ALA232A, ALA234A, ALA234E, ALA264E, ALA265E, ALA288E, ALA290E, ALA291E, ARG185E, ARG192E, ARG194E, ARG211A, ARG237E, ARG261E, ARG263E, ASN208A, ASN319E, ASP190E, ASP205A, ASP217E, ASP266E, ASP321E, ASP322E, CYS260E, CYS296E, GLN262A, GLN262E, GLU174A, GLU214E, GLU219E, GLU238A, GLU238E, GLU289E, GLY200A, GLY241E, GLY292E, GLY323E, HIS204A, HIS235A, HIS235E, ILE207A, ILE218E, ILE221E, ILE230A, ILE242E, ILE244E, ILE259E, LEU193E, LEU293E, LEU320E, LYS212A, LYS215E, LYS239A, LYS239E, LYS294E, PHE220E, PRO231A, PRO243E, SER202A, SER229A, THR225A, TRP201A, TRP228A, TYR216E, VAL165E, VAL203A, VAL226A, VAL236A, VAL236E, VAL240A, VAL240E, VAL245E
• A-F: ALA191A, ALA206F, ALA232F, ALA234A, ALA234F, ALA264A, ALA265A, ALA288A, ALA290A, ALA291A, ARG185A, ARG192A, ARG194A, ARG211F, ARG237A, ARG261A, ARG263A, ASN208F, ASN319A, ASP190A, ASP205F, ASP217A, ASP266A, ASP321A, ASP322A, CYS260A, CYS296A, GLN262A, GLU174F, GLU214A, GLU219A, GLU238A, GLU238F, GLU289A, GLY200F, GLY241A, GLY292A, GLY323A, HIS204F, HIS235A, HIS235F, ILE207F, ILE218A, ILE221A, ILE230F, ILE242A, ILE244A, ILE259A, LEU193A, LEU293A, LEU320A, LYS175F, LYS212F, LYS215A, LYS239A, LYS239F, LYS294A, PHE220A, PRO231F, PRO243A, SER202F, SER229F, THR225F, TRP201F, TRP228F, TYR216A, VAL165A, VAL203F, VAL226F, VAL236A, VAL236F, VAL240A, VAL240F, VAL245A
• A-G: ALA101A, ALA101G, ALA102A, ALA102G, ALA232A, ALA232G, ALA234A, ALA234G, ALA249A, ALA249G, ALA250G, ALA264A, ALA264G, ALA33A, ALA33G, ALA54A, ALA54G, ALA61A, ALA61G, ALA62A, ALA62G, ALA84A, ALA84G, ALA96A, ALA96G, ARG100A, ARG100G, ARG261A, ARG261G, ARG273A, ARG273G, ARG29A, ARG29G, ARG66A, ARG66G, ARG85A, ARG85G, ASN103A, ASN103G, ASN198A, ASN198G, ASN97A, ASN97G, ASP247A, ASP247G, ASP255A, ASP255G, ASP56A, ASP56G, GLN104A, GLN104G, GLN223A, GLN223G, GLN248A, GLN248G, GLN262A, GLN262G, GLN57A, GLN57G, GLN89A, GLN89G, GLU199A, GLU199G, GLU258A, GLU258G, GLU274A, GLU274G, GLU90A, GLU90G, GLY200A, GLY200G, GLY27A, GLY27G, GLY59A, GLY59G, GLY93A, GLY93G, GLY95A, GLY95G, HIS298A, HIS298G, HIS70A, HIS70G, HIS88A, HIS88G, HIS94A, HIS94G, ILE105A, ILE105G, ILE230A, ILE230G, ILE63A, ILE63G, ILE83G, ILE86A, ILE86G, ILE98A, ILE98G, LEU253A, LEU253G, LEU64A, LEU64G, LEU67A, LEU67G, LEU82G, LEU92A, LEU92G, LYS169A, PHE106A, PHE106G, PHE251A, PHE251G, PHE301A, PHE301G, PHE32A, PHE32G, PHE87A, PHE87G, PRO231A, PRO231G, PRO55A, PRO55G, PRO81G, SER227A, SER227G, SER229A, SER229G, SER25A, SER25G, SER299A, SER299G, SER300A, SER300G, SER31A, SER31G, THR252A, THR252G, THR52A, THR52G, THR58A, THR58G, THR60A, THR60G, TRP228A, TRP228G, TRP24A, TRP24G, TYR22A, TYR22G, TYR254A, TYR254G, TYR257A, TYR257G, TYR26A, TYR26G, TYR372A, TYR372G, TYR65A, TYR65G, TYR91A, TYR91G, VAL226A, VAL226G, VAL53A, VAL53G
• B-C: ALA191C, ALA206B, ALA232B, ALA234B, ALA234C, ALA264C, ALA265C, ALA288C, ALA290C, ALA291C, ARG185C, ARG192C, ARG194C, ARG211B, ARG237C, ARG261C, ARG263C, ASN208B, ASN319C, ASP190C, ASP205B, ASP217C, ASP266C, ASP321C, ASP322C, CYS260C, CYS296C, GLN262C, GLU174B, GLU214C, GLU219C, GLU238B, GLU238C, GLU289C, GLY200B, GLY241C, GLY292C, GLY323C, HIS204B, HIS235B, HIS235C, ILE207B, ILE218C, ILE221C, ILE230B, ILE242C, ILE244C, ILE259C, LEU178B, LEU193C, LEU293C, LEU320C, LYS175B, LYS212B, LYS215C, LYS239B, LYS239C, LYS294C, PHE220C, PRO231B, PRO243C, SER202B, SER229B, THR225B, TRP201B, TRP228B, TYR216C, VAL165C, VAL203B, VAL226B, VAL236B, VAL236C, VAL240B, VAL240C, VAL245C
• B-F: ALA101B, ALA101F, ALA102B, ALA102F, ALA232B, ALA232F, ALA234B, ALA249B, ALA249F, ALA264B, ALA33B, ALA54B, ALA54F, ALA61B, ALA61F, ALA62B, ALA62F, ALA84B, ALA84F, ALA96B, ALA96F, ARG100B, ARG100F, ARG261B, ARG261F, ARG273B, ARG273F, ARG29B, ARG29F, ARG66B, ARG66F, ARG85B, ARG85F, ASN103B, ASN103F, ASN198B, ASN198F, ASN97B, ASN97F, ASP247B, ASP255B, ASP255F, ASP56B, ASP56F, GLN104B, GLN104F, GLN223B, GLN223F, GLN248B, GLN248F, GLN262B, GLN262F, GLN57B, GLN57F, GLN89B, GLN89F, GLU199B, GLU199F, GLU258B, GLU258F, GLU274B, GLU274F, GLU90B, GLU90F, GLY200B, GLY27B, GLY27F, GLY59B, GLY59F, GLY93B, GLY93F, GLY95B, GLY95F, HIS298B, HIS298F, HIS70B, HIS70F, HIS88B, HIS88F, HIS94B, HIS94F, ILE105B, ILE105F, ILE230B, ILE230F, ILE63B, ILE63F, ILE86B, ILE86F, ILE98B, ILE98F, LEU253B, LEU253F, LEU64B, LEU64F, LEU67B, LEU67F, LEU92B, LEU92F, LYS69B, LYS69F, PHE106B, PHE106F, PHE251B, PHE251F, PHE301B, PHE301F, PHE32B, PHE32F, PHE87B, PHE87F, PRO231B, PRO231F, PRO55B, PRO55F, PRO81F, SER227B, SER227F, SER229B, SER229F, SER25B, SER25F, SER299B, SER299F, SER300B, SER300F, SER31B, SER31F, SER375B, THR252B, THR252F, THR52B, THR52F, THR58B, THR58F, THR60B, THR60F, TRP228B, TRP228F, TRP24B, TRP24F, TYR22B, TYR22F, TYR254B, TYR254F, TYR257B, TYR257F, TYR26B, TYR26F, TYR372B, TYR372F, TYR65B, TYR91B, TYR91F, VAL226B, VAL226F, VAL53B, VAL53F
• B-G: ALA191B, ALA206G, ALA232G, ALA234B, ALA234G, ALA264B, ALA265B, ALA288B, ALA290B, ALA291B, ARG185B, ARG192B, ARG194B, ARG211G, ARG237B, ARG261B, ARG263B, ASN208G, ASN319B, ASP190B, ASP205G, ASP217B, ASP266B, ASP321B, ASP322B, CYS260B, CYS296B, GLN262B, GLU174G, GLU214B, GLU219B, GLU238B, GLU238G, GLU289B, GLY200G, GLY241B, GLY292B, GLY323B, HIS204G, HIS235G, ILE207G, ILE218B, ILE221B, ILE230G, ILE242B, ILE244B, ILE259B, LEU178G, LEU193B, LEU293B, LEU320B, LYS175G, LYS212G, LYS215B, LYS239B, LYS239G, LYS294B, PHE220B, PRO231G, PRO243B, SER202G, SER229G, THR225G, TRP201G, TRP228G, TYR216B, VAL165B, VAL203G, VAL226G, VAL236B, VAL236G, VAL240B, VAL240G, VAL245B
• C-D: ALA191D, ALA206C, ALA232C, ALA234C, ALA234D, ALA264D, ALA265D, ALA288D, ALA290D, ALA291D, ARG185D, ARG192D, ARG194D, ARG211C, ARG237D, ARG261D, ARG263D, ASN208C, ASN319D, ASP190D, ASP205C, ASP217D, ASP266D, ASP321D, ASP322D, CYS260D, CYS296D, GLN262D, GLU174C, GLU214D, GLU219D, GLU238C, GLU238D, GLU289D, GLY200C, GLY241D, GLY292D, GLY323D, HIS204C, HIS235C, HIS235D, ILE207C, ILE218D, ILE221D, ILE230C, ILE242D, ILE244D, ILE259D, LEU178C, LEU193D, LEU293D, LEU320D, LYS175C, LYS212C, LYS215D, LYS239C, LYS239D, LYS294D, PHE220D, PRO231C, PRO243D, SER202C, SER229C, THR225C, TRP201C, TRP228C, TYR216D, VAL165D, VAL203C, VAL226C, VAL236C, VAL236D, VAL240C, VAL240D, VAL245D
• C-F: ALA121C, ALA121F, ALA132C, ALA132F, ALA284C, ALA284F, ALA285C, ALA285F, ALA286C, ALA286F, ALA288C, ALA288F, ALA290C, ALA290F, ALA291C, ALA291F, ALA316C, ALA316F, ALA80C, ALA80F, ALA84C, ALA84F, ARG134C, ARG134F, ARG261C, ARG261F, ARG263C, ARG263F, ARG352F, ARG85C, ARG85F, ASN319C, ASN319F, ASP110C, ASP110F, ASP255C, ASP255F, ASP78C, ASP78F, CYS260C, CYS260F, GLN117C, GLN117F, GLN127C, GLN127F, GLN262C, GLN262F, GLN279C, GLN279F, GLU258C, GLU258F, GLU289C, GLU289F, GLY122F, GLY130C, GLY130F, GLY131C, GLY131F, GLY292C, GLY292F, HIS126C, HIS126F, HIS133C, HIS133F, HIS77C, HIS77F, ILE259C, ILE259F, ILE275C, ILE275F, ILE317C, ILE317F, ILE83C, ILE83F, LEU120C, LEU120F, LEU123C, LEU123F, LEU128C, LEU128F, LEU129C, LEU129F, LEU253C, LEU253F, LEU293C, LEU293F, LEU315C, LEU315F, LEU82C, LEU82F, LYS283C, LYS283F, LYS5C, PRO124C, PRO124F, PRO280C, PRO280F, PRO318C, PRO318F, PRO76C, PRO76F, PRO81C, PRO81F, SER75C, SER75F, THR252C, THR252F, TRP114C, TRP114F, TYR254C, TYR254F, TYR257C, TYR257F, VAL256C, VAL256F, VAL287C, VAL287F, VAL4C, VAL4F, VAL79C, VAL79F
• C-H: ALA101C, ALA101H, ALA102C, ALA102H, ALA232C, ALA232H, ALA234C, ALA234H, ALA249C, ALA249H, ALA264C, ALA33C, ALA33H, ALA54C, ALA54H, ALA61C, ALA61H, ALA62C, ALA62H, ALA84C, ALA84H, ALA96C, ALA96H, ARG100C, ARG100H, ARG261C, ARG261H, ARG273C, ARG273H, ARG29C, ARG29H, ARG376C, ARG66C, ARG66H, ARG85C, ARG85H, ASN103C, ASN103H, ASN198C, ASN198H, ASN97C, ASN97H, ASP255C, ASP255H, ASP56C, ASP56H, GLN104C, GLN104H, GLN223C, GLN223H, GLN248C, GLN248H, GLN262C, GLN262H, GLN57C, GLN57H, GLN89C, GLN89H, GLU199C, GLU199H, GLU258C, GLU258H, GLU274C, GLU274H, GLU90C, GLU90H, GLY27C, GLY27H, GLY59C, GLY59H, GLY93C, GLY93H, GLY95C, GLY95H, HIS298C, HIS298H, HIS70C, HIS70H, HIS88C, HIS88H, HIS94C, HIS94H, ILE105C, ILE105H, ILE230C, ILE230H, ILE63C, ILE63H, ILE86C, ILE86H, ILE98C, ILE98H, LEU253C, LEU253H, LEU64C, LEU64H, LEU67C, LEU67H, LEU82H, LEU92C, LEU92H, LYS169C, LYS169H, LYS69C, PHE106C, PHE106H, PHE251C, PHE251H, PHE301C, PHE301H, PHE32C, PHE32H, PHE87C, PHE87H, PRO231C, PRO231H, PRO55C, PRO55H, PRO81H, SER227C, SER227H, SER229C, SER229H, SER25C, SER25H, SER299C, SER299H, SER300C, SER300H, SER31C, SER31H, THR252C, THR252H, THR52C, THR52H, THR58C, THR58H, THR60C, THR60H, TRP228C, TRP228H, TRP24C, TRP24H, TYR22C, TYR22H, TYR254C, TYR254H, TYR257C, TYR257H, TYR26C, TYR26H, TYR372C, TYR65H, TYR91C, TYR91H, VAL226C, VAL226H, VAL53C, VAL53H
• D-E: ALA101D, ALA101E, ALA102D, ALA102E, ALA232D, ALA232E, ALA234D, ALA234E, ALA249D, ALA249E, ALA250E, ALA264E, ALA33D, ALA33E, ALA54D, ALA54E, ALA61D, ALA61E, ALA62D, ALA62E, ALA84D, ALA84E, ALA96D, ALA96E, ARG100D, ARG100E, ARG261D, ARG261E, ARG273D, ARG273E, ARG29D, ARG29E, ARG66D, ARG66E, ARG85D, ARG85E, ASN103D, ASN103E, ASN198D, ASN198E, ASN97D, ASN97E, ASP247E, ASP255D, ASP255E, ASP56D, ASP56E, GLN104D, GLN104E, GLN223D, GLN223E, GLN248D, GLN248E, GLN262D, GLN262E, GLN57D, GLN57E, GLN89D, GLN89E, GLU199D, GLU199E, GLU258D, GLU258E, GLU274D, GLU274E, GLU90D, GLU90E, GLY200D, GLY200E, GLY27D, GLY27E, GLY59D, GLY59E, GLY93D, GLY93E, GLY95D, GLY95E, HIS298D, HIS298E, HIS70D, HIS70E, HIS88D, HIS88E, HIS94D, HIS94E, ILE105D, ILE105E, ILE230D, ILE230E, ILE63D, ILE63E, ILE86D, ILE86E, ILE98D, ILE98E, LEU253D, LEU253E, LEU64D, LEU64E, LEU67D, LEU67E, LEU82E, LEU92D, LEU92E, PHE106D, PHE106E, PHE251D, PHE251E, PHE301D, PHE301E, PHE32E, PHE87D, PHE87E, PRO231D, PRO231E, PRO55D, PRO55E, PRO81E, SER227D, SER227E, SER229D, SER229E, SER25D, SER25E, SER299D, SER299E, SER300D, SER300E, SER31D, SER31E, THR252D, THR252E, THR52D, THR52E, THR58D, THR58E, THR60D, THR60E, TRP228D, TRP228E, TRP24D, TRP24E, TYR22D, TYR22E, TYR254D, TYR254E, TYR257D, TYR257E, TYR26D, TYR26E, TYR372E, TYR65D, TYR91D, TYR91E, VAL226D, VAL226E, VAL53D, VAL53E
• D-G: ALA191G, ALA206D, ALA232D, ALA234D, ALA234G, ALA264G, ALA265G, ALA288G, ALA290G, ALA291G, ARG185G, ARG192G, ARG194G, ARG211D, ARG237G, ARG261G, ARG263G, ASN208D, ASN319G, ASP190G, ASP205D, ASP217G, ASP266G, ASP321G, ASP322G, CYS260G, CYS296G, GLN262D, GLN262G, GLU174D, GLU214G, GLU219G, GLU238D, GLU238G, GLU289G, GLY200D, GLY241G, GLY292G, HIS204D, HIS235D, HIS235G, ILE207D, ILE218G, ILE221G, ILE230D, ILE242G, ILE244G, ILE259G, LEU178D, LEU193G, LEU293G, LEU320G, LYS175D, LYS212D, LYS215G, LYS239D, LYS239G, LYS294G, PHE220G, PRO231D, PRO243G, SER202D, SER229D, THR225D, TRP201D, TRP228D, TYR216G, VAL165G, VAL203D, VAL226D, VAL236D, VAL236G, VAL240D, VAL240G, VAL245G
• D-H: ALA121D, ALA121H, ALA132D, ALA132H, ALA284D, ALA284H, ALA285D, ALA285H, ALA286D, ALA286H, ALA288D, ALA288H, ALA290D, ALA290H, ALA291D, ALA291H, ALA316D, ALA316H, ALA80D, ALA80H, ALA84D, ALA84H, ARG134D, ARG134H, ARG261D, ARG261H, ARG263D, ARG263H, ARG352D, ARG352H, ARG85D, ARG85H, ASN319D, ASN319H, ASP110D, ASP110H, ASP255D, ASP255H, ASP78D, ASP78H, CYS260D, CYS260H, GLN117D, GLN117H, GLN127D, GLN127H, GLN262D, GLN262H, GLN279D, GLN279H, GLU258D, GLU258H, GLU289D, GLU289H, GLY122H, GLY130D, GLY130H, GLY131D, GLY131H, GLY292D, GLY292H, HIS126D, HIS126H, HIS133D, HIS133H, HIS74H, HIS77D, HIS77H, ILE259D, ILE259H, ILE275D, ILE275H, ILE317D, ILE317H, ILE83D, ILE83H, LEU120D, LEU120H, LEU123D, LEU123H, LEU128D, LEU128H, LEU129D, LEU129H, LEU253D, LEU253H, LEU293D, LEU293H, LEU315D, LEU315H, LEU82D, LEU82H, LYS135H, LYS283D, LYS283H, LYS5D, PRO124D, PRO124H, PRO280D, PRO280H, PRO318D, PRO318H, PRO76D, PRO76H, PRO81D, PRO81H, SER75D, SER75H, THR252D, THR252H, TRP114D, TRP114H, TYR254D, TYR254H, TYR257D, TYR257H, VAL256D, VAL256H, VAL287D, VAL287H, VAL4D, VAL4H, VAL79D, VAL79H
• E-G: ALA121E, ALA121G, ALA132E, ALA132G, ALA284E, ALA284G, ALA285E, ALA285G, ALA286E, ALA286G, ALA288E, ALA288G, ALA290E, ALA290G, ALA291E, ALA291G, ALA316E, ALA316G, ALA80E, ALA80G, ALA84E, ALA84G, ARG134E, ARG134G, ARG261E, ARG261G, ARG263E, ARG263G, ARG352E, ARG85E, ARG85G, ASN319E, ASN319G, ASP110E, ASP110G, ASP255E, ASP255G, ASP78E, ASP78G, CYS260E, CYS260G, GLN117E, GLN117G, GLN127E, GLN127G, GLN262E, GLN262G, GLN279E, GLN279G, GLU258E, GLU258G, GLU289E, GLU289G, GLY130E, GLY130G, GLY131E, GLY131G, GLY292E, GLY292G, HIS126E, HIS126G, HIS133E, HIS133G, HIS74E, HIS77E, HIS77G, ILE259E, ILE259G, ILE268G, ILE317E, ILE317G, ILE83E, ILE83G, LEU120E, LEU120G, LEU123E, LEU123G, LEU128E, LEU128G, LEU129E, LEU129G, LEU253E, LEU253G, LEU293E, LEU293G, LEU315E, LEU315G, LEU82E, LEU82G, LYS135E, LYS283E, LYS283G, LYS5E, LYS5G, PRO124E, PRO124G, PRO280E, PRO280G, PRO318E, PRO318G, PRO76E, PRO76G, PRO81E, PRO81G, SER75E, SER75G, THR252E, THR252G, TRP114E, TRP114G, TYR254E, TYR254G, TYR257E, TYR257G, VAL256E, VAL256G, VAL287E, VAL287G, VAL4E, VAL4G, VAL79E, VAL79G
• E-H: ALA191H, ALA206E, ALA232E, ALA234E, ALA234H, ALA264H, ALA265H, ALA288H, ALA290H, ALA291H, ARG185H, ARG192H, ARG194H, ARG211E, ARG237H, ARG261H, ARG263H, ASN208E, ASN319H, ASP190H, ASP205E, ASP217H, ASP266H, ASP321H, ASP322H, CYS260H, CYS296H, GLN262H, GLU174E, GLU214H, GLU219H, GLU238E, GLU238H, GLU289H, GLY200E, GLY241H, GLY292H, GLY323H, HIS204E, HIS235E, HIS235H, ILE207E, ILE218H, ILE221H, ILE230E, ILE242H, ILE244H, ILE259H, LEU178E, LEU193H, LEU293H, LEU320H, LYS175E, LYS212E, LYS215H, LYS239E, LYS239H, LYS294H, PHE220H, PRO231E, PRO243H, SER202E, SER229E, THR225E, TRP201E, TRP228E, TYR216H, VAL165H, VAL203E, VAL226E, VAL236E, VAL236H, VAL240E, VAL240H, VAL245H
• F-H: ALA191F, ALA206H, ALA232H, ALA234F, ALA234H, ALA264F, ALA265F, ALA288F, ALA290F, ALA291F, ARG185F, ARG192F, ARG194F, ARG211H, ARG237F, ARG261F, ARG263F, ASN208H, ASN319F, ASP190F, ASP205H, ASP217F, ASP266F, ASP321F, ASP322F, CYS260F, CYS296F, GLN262F, GLU174H, GLU214F, GLU219F, GLU238F, GLU238H, GLU289F, GLY200H, GLY241F, GLY292F, GLY323F, HIS204H, HIS235F, HIS235H, ILE207H, ILE218F, ILE221F, ILE230H, ILE242F, ILE244F, ILE259F, LEU193F, LEU293F, LEU320F, LYS175H, LYS212H, LYS215F, LYS239F, LYS239H, LYS294F, PHE220F, PRO231H, PRO243F, SER202H, SER229H, THR225H, TRP201H, TRP228H, TYR216F, VAL165F, VAL203H, VAL226H, VAL236F, VAL236H, VAL240F, VAL240H, VAL245F