2PG1

structural analysis of a cytoplasmic dynein light chain- intermediate chain complex

• Total interactions analyzed: 66
• Total true interactions: 30
• Strongest Interaction:
  • Chains: F-I
  • Int. Res.: 52
  • Norm. En. per Res.: -6.7554
• Hub Node: E(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-138.7857	6.4996	-349.132	-481.4181	82	28	10	11823	0	8	20
A-I	-71.2934	0.7278	-199.227	-269.7926	46	20	1	7037	0	8	8
A-L	-17.7337	0.041	-41.1517	-58.8443	32	3	0	1501	1	7	7
B-G	0.0	4.1189	-16.1554	-12.0365	24	0	0	923	0	6	10
B-I	-21.1384	-6.7731	-39.4161	-67.3276	32	5	0	1527	2	7	7
B-L	-60.7631	3.8911	-187.184	-244.0559	44	10	1	6465	0	5	8
C-D	-138.8672	5.7562	-358.92	-492.031	82	24	10	11787	0	8	20
C-E	0.0	2.0594	-8.8091	-6.7497	21	0	0	545	0	5	9
C-J	-12.7927	2.79	-30.8712	-40.874	36	1	0	1498	1	8	8
C-K	-90.1719	2.3235	-183.793	-271.6414	46	16	0	6623	0	5	8
D-J	-82.2594	3.103	-210.433	-289.5894	48	21	1	7240	0	9	8
D-K	-26.419	-3.4471	-36.8262	-66.6922	32	2	0	1424	2	7	7
E-G	-46.8407	44.0313	-47.9905	-50.7999	42	5	1	1740	0	14	14
E-H	-232.8395	-22.3249	-470.882	-726.0464	127	40	13	16706	4	10	8
E-J	-14.799	-23.4727	-60.8731	-99.1447	52	5	1	2698	2	5	5
E-K	-113.9945	-11.258	-225.009	-350.2615	55	15	5	7508	1	8	4
E-L	-10.4654	4.928	-30.9251	-36.4625	28	1	0	1012	0	2	4
F-G	-204.3541	-26.1795	-421.502	-652.0356	124	34	14	16066	4	10	8
F-H	0.0	2.0614	-10.3558	-8.2944	20	2	0	705	1	5	3
F-I	-91.7253	-14.7872	-244.768	-351.2805	52	18	5	7867	0	8	4
F-K	0.0	15.2787	-2.1671	13.1116	10	0	0	160	0	0	2
F-L	-3.3911	-10.9624	-59.6165	-73.97	54	1	0	2625	0	5	4
G-H	0.0	0.0	-0.0172	-0.0172	2	0	0	4	0	1	0
G-I	-4.9177	-25.208	-40.9622	-71.0879	51	6	1	2403	2	4	6
G-K	-16.0171	4.5639	-25.3689	-36.8221	26	3	0	1105	1	2	4
G-L	-99.8456	-15.8944	-226.916	-342.6561	59	13	5	7813	1	8	4
H-J	-104.4036	-6.6933	-244.882	-355.9789	55	14	5	8026	2	9	4
H-K	0.0	-15.4062	-52.3817	-67.7879	55	5	2	2680	2	5	4
H-L	0.0	19.3412	-2.1395	17.2017	15	0	0	149	0	0	2
K-L	-57.5401	0.0	-75.8435	-133.3836	24	7	0	3103	0	2	1

Interface residues

• A-B: ALA39A, ALA39B, ALA40A, ALA40B, ALA82A, ALA82B, ARG60A, ARG60B, ASN61A, ASN61B, ASP37A, ASP37B, ASP47A, ASP47B, CYS56A, CYS56B, GLN80B, GLU35A, GLU35B, GLU45A, GLU45B, GLU69A, GLU69B, GLY59A, GLY59B, GLY63A, GLY63B, GLY89A, GLY89B, HIS55A, HIS55B, HIS68A, HIS68B, ILE34A, ILE34B, ILE38A, ILE38B, ILE42A, ILE42B, ILE57A, ILE57B, ILE83B, LEU84A, LEU84B, LEU85A, LEU85B, LYS36A, LYS36B, LYS43A, LYS43B, LYS44A, LYS44B, LYS87A, LYS87B, PHE62A, PHE62B, PHE86A, PHE86B, PRO52A, PRO52B, SER64A, SER64B, SER88A, SER88B, THR53A, THR53B, THR67A, THR67B, TRP54A, TRP54B, TYR41A, TYR41B, TYR65A, TYR65B, TYR75A, TYR75B, VAL58A, VAL58B, VAL66A, VAL66B, VAL81A, VAL81B
• A-I: ALA11A, ALA82A, ARG60A, ARG71A, ASN10A, ASN61A, ASP12A, GLN135I, GLN80A, GLU126I, GLU133I, GLU69A, GLY59A, GLY63A, GLY89A, HIS68A, HIS72A, ILE127I, ILE57A, ILE74A, ILE83A, LEU84A, LEU85A, LYS132I, LYS87A, LYS9A, PHE62A, PHE73A, PHE76A, PHE86A, PRO137I, SER64A, SER88A, THR129I, THR131I, THR134I, THR136I, THR67A, THR70A, TYR130I, TYR65A, TYR75A, TYR77A, VAL128I, VAL66A, VAL81A
• A-L: ALA39A, ALA40A, ARG60A, ASN33A, ASN61A, ASP37A, ASP47A, CYS56A, GLN135L, GLU133L, GLU35A, GLY59A, GLY89A, HIS55A, ILE127L, ILE34A, ILE38A, ILE57A, LYS132L, LYS36A, LYS43A, LYS44A, PHE62A, PRO52A, THR129L, THR131L, THR134L, THR136L, THR53A, TRP54A, TYR130L, VAL58A
• B-G: ALA31G, ARG71B, ASN30G, ASN51B, ASP35G, GLN33G, GLU69B, GLY29G, HIS72B, LYS36G, LYS48B, LYS49B, LYS70G, LYS87B, LYS98G, MET13B, MET17B, PRO52B, SER14B, THR70B, THR99G, TRP40G, TYR32G, TYR50B
• B-I: ALA39B, ALA40B, ARG60B, ASN33B, ASN61B, ASP37B, ASP47B, CYS56B, GLN135I, GLU133I, GLU35B, GLY59B, GLY89B, HIS55B, ILE127I, ILE34B, ILE38B, ILE57B, LYS132I, LYS36B, LYS43B, LYS44B, PHE62B, PRO52B, THR129I, THR131I, THR134I, THR136I, THR53B, TRP54B, TYR130I, VAL58B
• B-L: ALA11B, ALA82B, ARG60B, ARG71B, ASN10B, ASN61B, ASP12B, GLN135L, GLU133L, GLU69B, GLY59B, GLY63B, HIS68B, HIS72B, ILE127L, ILE57B, ILE74B, ILE83B, LEU84B, LEU85B, LYS132L, LYS9B, PHE62B, PHE73B, PHE76B, PHE86B, PRO137L, SER64B, SER88B, THR129L, THR131L, THR134L, THR136L, THR67B, THR70B, TYR130L, TYR65B, TYR75B, TYR77B, VAL128L, VAL138L, VAL58B, VAL66B, VAL81B
• C-D: ALA39C, ALA39D, ALA40C, ALA40D, ALA82C, ALA82D, ARG60C, ARG60D, ASN61C, ASN61D, ASP37C, ASP37D, ASP47C, ASP47D, CYS56C, CYS56D, GLN80C, GLU35C, GLU35D, GLU45C, GLU45D, GLU69C, GLU69D, GLY59C, GLY59D, GLY63C, GLY63D, GLY89C, GLY89D, HIS55C, HIS55D, HIS68C, HIS68D, ILE34C, ILE34D, ILE38C, ILE38D, ILE42C, ILE42D, ILE57C, ILE57D, ILE83C, ILE83D, LEU84C, LEU84D, LEU85C, LEU85D, LYS36C, LYS36D, LYS43C, LYS43D, LYS44C, LYS44D, LYS87C, LYS87D, PHE62C, PHE62D, PHE86C, PHE86D, PRO52C, PRO52D, SER64C, SER64D, SER88C, SER88D, THR53C, THR53D, THR67C, THR67D, TRP54C, TRP54D, TYR41C, TYR41D, TYR65C, TYR65D, TYR75C, VAL58C, VAL58D, VAL66C, VAL66D, VAL81C, VAL81D
• C-E: ALA31E, ARG71C, ASN30E, ASN51C, GLN33E, GLU69C, HIS34E, HIS72C, LYS36E, LYS48C, LYS49C, LYS87C, LYS98E, MET17C, PRO52C, SER14C, THR70C, THR99E, TRP40E, TYR32E, TYR50C
• C-J: ALA39C, ALA40C, ARG60C, ASN33C, ASN61C, ASP37C, ASP47C, CYS56C, GLN135J, GLU126J, GLU133J, GLU35C, GLY59C, GLY89C, HIS55C, ILE127J, ILE34C, ILE38C, ILE57C, LYS132J, LYS36C, LYS43C, LYS44C, PHE62C, PRO52C, SER88C, THR129J, THR131J, THR134J, THR136J, THR53C, TRP54C, TYR130J, TYR41C, VAL138J, VAL58C
• C-K: ALA11C, ALA82C, ARG60C, ARG71C, ASN10C, ASN61C, ASP12C, GLN135K, GLU133K, GLU69C, GLY59C, GLY63C, GLY89C, HIS68C, HIS72C, ILE127K, ILE57C, ILE74C, ILE83C, LEU84C, LEU85C, LYS132K, LYS87C, LYS9C, PHE62C, PHE73C, PHE76C, PHE86C, PRO137K, SER64C, SER88C, THR129K, THR131K, THR134K, THR136K, THR67C, THR70C, TYR130K, TYR65C, TYR75C, TYR77C, VAL128K, VAL138K, VAL58C, VAL66C, VAL81C
• D-J: ALA11D, ALA82D, ARG60D, ARG71D, ASN10D, ASN61D, ASP12D, GLN135J, GLN80D, GLU126J, GLU133J, GLU69D, GLY59D, GLY63D, GLY79D, GLY89D, HIS68D, HIS72D, ILE127J, ILE57D, ILE74D, ILE83D, LEU84D, LEU85D, LYS132J, LYS87D, LYS9D, PHE62D, PHE73D, PHE76D, PHE86D, PRO137J, SER64D, SER88D, THR129J, THR131J, THR134J, THR136J, THR67D, THR70D, TYR130J, TYR65D, TYR75D, TYR77D, VAL128J, VAL138J, VAL66D, VAL81D
• D-K: ALA39D, ALA40D, ARG60D, ASN33D, ASN61D, ASP37D, ASP47D, CYS56D, GLN135K, GLU133K, GLU35D, GLY59D, GLY89D, HIS55D, ILE127K, ILE34D, ILE38D, ILE57D, LYS132K, LYS36D, LYS43D, LYS44D, PHE62D, THR129K, THR131K, THR134K, THR136K, THR53D, TRP54D, TYR130K, VAL138K, VAL58D
• E-G: ARG94E, ARG94G, ASN84E, ASN84G, ASN85E, ASN85G, ASP13E, ASP13G, ASP14E, ASP14G, ASP86E, ASP86G, CYS81E, CYS81G, CYS91E, CYS91G, GLN9E, GLN9G, GLU96G, ILE11E, ILE11G, LYS17E, LYS17G, LYS20E, LYS20G, PHE10E, PHE10G, SER16E, SER16G, SER80E, SER80G, SER90E, SER90G, TRP83E, TRP83G, TRP95G, TYR101E, VAL12E, VAL12G, VAL15E, VAL15G, VAL93G
• E-H: ALA110E, ALA110H, ALA65E, ALA65H, ALA73E, ALA73H, ALA78E, ALA78H, ASN38E, ASN38H, ASN39E, ASN39H, ASN71E, ASN71H, ASN84E, ASN84H, ASN85E, ASN85H, ASP35E, ASP35H, ASP86E, ASP86H, ASP88E, ASP88H, CYS102E, CYS102H, CYS81E, CYS81H, GLN33E, GLN33H, GLN43E, GLN43H, GLN56E, GLN56H, GLN69E, GLN69H, GLU46E, GLU46H, GLY108E, GLY108H, GLY42E, GLY42H, GLY72E, GLY72H, GLY74E, GLY74H, GLY89E, GLY89H, HIS34E, HIS34H, HIS76E, HIS76H, ILE103E, ILE103H, ILE62E, ILE62H, ILE67E, ILE67H, LEU109E, LEU109H, LEU49E, LEU49H, LEU52E, LEU52H, LEU75E, LEU75H, LYS36E, LYS36H, LYS57E, LYS57H, LYS60E, LYS60H, LYS70E, LYS70H, PHE107E, PHE107H, PRO58E, PRO58H, SER105E, SER105H, SER79E, SER79H, SER80E, SER80H, SER90E, SER90H, THR41E, THR41H, THR50E, THR50H, THR53E, THR53H, THR64E, THR64H, THR77E, THR77H, THR87E, THR87H, THR92H, TRP40E, TRP40H, TRP83E, TRP83H, TYR101E, TYR101H, TYR32E, TYR32H, TYR59E, TYR59H, TYR61E, TYR61H, TYR82E, TYR82H, VAL104E, VAL104H, VAL106E, VAL106H, VAL111E, VAL111H, VAL37E, VAL37H, VAL44E, VAL44H, VAL45E, VAL45H, VAL63E, VAL63H
• E-J: ALA110E, ALA115J, ALA65E, ARG125J, ASN38E, ASN39E, ASN71E, ASP121J, ASP35E, CYS48E, GLN119J, GLN33E, GLN43E, GLN69E, GLU126J, GLU46E, GLY113J, GLY42E, HIS34E, ILE110J, ILE117J, ILE62E, ILE67E, LEU109E, LEU112J, LEU49E, LEU52E, LYS111J, LYS116J, LYS57E, LYS60E, MET114J, PHE122J, PRO123J, PRO124J, PRO58E, THR118J, THR41E, THR50E, THR53E, THR64E, TRP40E, TYR32E, TYR59E, TYR61E, VAL111E, VAL120J, VAL37E, VAL44E, VAL45E, VAL51E, VAL63E
• E-K: ALA115K, ALA73E, ALA78E, ARG125K, ARG94E, ASN71E, ASN84E, ASN85E, ASN97E, ASP121K, ASP86E, ASP88E, CYS102E, CYS81E, CYS91E, GLN119K, GLN69E, GLU126K, GLU96E, GLY113K, GLY72E, GLY74E, GLY89E, HIS76E, ILE103E, ILE110K, ILE117K, ILE127K, LEU109E, LEU112K, LEU75E, LYS111K, LYS116K, LYS70E, MET114K, PHE107E, PHE122K, PRO123K, PRO124K, SER105E, SER79E, SER80E, SER90E, THR118K, THR77E, THR87E, THR92E, TRP83E, TRP95E, TYR101E, TYR82E, VAL104E, VAL120K, VAL12E, VAL93E
• E-L: ALA115L, ALA78E, ARG125L, ARG94E, ASN85E, CYS91E, GLN119L, GLU96E, GLY113L, HIS76E, ILE103E, ILE117L, LYS111L, LYS116L, LYS20E, MET114L, PHE122L, SER105E, SER16E, SER79E, SER80E, THR77E, THR92E, TYR101E, TYR82E, VAL104E, VAL12E, VAL93E
• F-G: ALA110F, ALA110G, ALA65F, ALA65G, ALA73F, ALA73G, ALA78F, ALA78G, ASN38F, ASN38G, ASN39F, ASN39G, ASN71F, ASN71G, ASN84F, ASN84G, ASN85F, ASN85G, ASP35F, ASP86G, ASP88F, ASP88G, CYS102F, CYS102G, CYS81F, CYS81G, GLN33F, GLN43F, GLN43G, GLN56F, GLN56G, GLN69F, GLN69G, GLU46F, GLU46G, GLY108F, GLY108G, GLY42F, GLY42G, GLY72F, GLY72G, GLY74F, GLY74G, GLY89F, GLY89G, HIS34F, HIS34G, HIS76F, HIS76G, ILE103F, ILE103G, ILE62F, ILE62G, ILE67F, ILE67G, LEU109F, LEU109G, LEU49F, LEU49G, LEU52F, LEU52G, LEU75F, LEU75G, LYS36F, LYS54F, LYS57F, LYS57G, LYS60F, LYS60G, LYS70F, LYS70G, PHE107F, PHE107G, PRO58F, PRO58G, SER105F, SER105G, SER79F, SER79G, SER80F, SER80G, SER90F, SER90G, THR41F, THR41G, THR50F, THR50G, THR53F, THR53G, THR64F, THR64G, THR77F, THR77G, THR87F, THR87G, THR92G, TRP40F, TRP40G, TRP83F, TRP83G, TYR101F, TYR101G, TYR32F, TYR32G, TYR59F, TYR59G, TYR61F, TYR61G, TYR82F, TYR82G, VAL104F, VAL104G, VAL106F, VAL106G, VAL111F, VAL111G, VAL37F, VAL37G, VAL44F, VAL44G, VAL45F, VAL45G, VAL63F, VAL63G
• F-H: ASN38F, ASN38H, ASN39F, ASN39H, ASP35F, ASP35H, GLN43F, GLN43H, GLU46F, GLU46H, GLY42F, GLY42H, HIS34F, HIS34H, LYS36F, LYS36H, THR50F, THR50H, TRP40F, TRP40H
• F-I: ALA115I, ALA73F, ALA78F, ARG125I, ARG94F, ASN71F, ASN84F, ASN85F, ASP121I, ASP86F, ASP88F, CYS102F, CYS81F, CYS91F, GLN119I, GLU126I, GLU96F, GLY113I, GLY72F, GLY74F, GLY89F, HIS76F, ILE103F, ILE117I, ILE67F, LEU109F, LEU112I, LEU75F, LYS111I, LYS116I, LYS70F, MET114I, PHE107F, PHE122I, PRO123I, PRO124I, SER105F, SER79F, SER80F, SER90F, THR118I, THR77F, THR87F, THR92F, TRP83F, TRP95F, TYR101F, TYR82F, VAL104F, VAL111F, VAL120I, VAL93F
• F-K: ASN38F, ASN39F, ASP121K, GLN119K, GLU46F, GLY42F, ILE117K, PRO123K, THR41F, THR50F
• F-L: ALA110F, ALA115L, ALA65F, ARG125L, ASN38F, ASN39F, ASN71F, ASP121L, ASP35F, CYS48F, GLN119L, GLN33F, GLN43F, GLN56F, GLN69F, GLU126L, GLU46F, GLY113L, GLY42F, HIS34F, ILE110L, ILE117L, ILE127L, ILE62F, ILE67F, LEU109F, LEU112L, LEU49F, LEU52F, LYS111L, LYS116L, LYS57F, LYS60F, MET114L, PHE122L, PRO123L, PRO124L, PRO58F, THR118L, THR41F, THR50F, THR53F, THR64F, TRP40F, TYR32F, TYR59F, TYR61F, VAL111F, VAL120L, VAL37F, VAL44F, VAL45F, VAL51F, VAL63F
• G-H: GLU46H, HIS76G
• G-I: ALA110G, ALA115I, ALA65G, ARG125I, ASN38G, ASN39G, ASN71G, ASP121I, ASP35G, CYS48G, GLN119I, GLN33G, GLN43G, GLN69G, GLU126I, GLU46G, GLY113I, GLY42G, HIS34G, ILE117I, ILE62G, ILE67G, LEU109G, LEU112I, LEU49G, LEU52G, LYS111I, LYS116I, LYS54G, LYS57G, LYS60G, MET114I, PHE122I, PRO123I, PRO124I, PRO58G, THR118I, THR41G, THR50G, THR53G, THR64G, TRP40G, TYR32G, TYR59G, TYR61G, VAL111G, VAL120I, VAL37G, VAL45G, VAL51G, VAL63G
• G-K: ALA115K, ALA78G, ARG94G, ASN97G, ASP121K, CYS91G, GLN119K, GLU96G, GLY113K, HIS76G, ILE103G, ILE117K, LYS111K, LYS116K, LYS20G, LYS70G, MET114K, SER105G, SER79G, SER80G, THR77G, THR92G, TRP95G, TYR101G, VAL104G, VAL93G
• G-L: ALA110G, ALA115L, ALA73G, ALA78G, ARG125L, ARG94G, ASN71G, ASN84G, ASN85G, ASP121L, ASP86G, ASP88G, CYS102G, CYS81G, CYS91G, GLN119L, GLU126L, GLU96G, GLY113L, GLY72G, GLY74G, GLY89G, HIS76G, ILE103G, ILE110L, ILE117L, ILE127L, ILE67G, LEU109G, LEU112L, LEU75G, LYS111L, LYS116L, LYS70G, LYS98G, MET114L, PHE107G, PHE122L, PRO123L, PRO124L, SER105G, SER79G, SER80G, SER90G, THR118L, THR77G, THR87G, THR92G, THR99G, TRP83G, TRP95G, TYR101G, TYR82G, VAL104G, VAL111G, VAL120L, VAL128L, VAL12G, VAL93G
• H-J: ALA115J, ALA73H, ALA78H, ARG125J, ARG94H, ASN71H, ASN84H, ASN85H, ASN97H, ASP121J, ASP86H, ASP88H, CYS102H, CYS81H, CYS91H, GLN119J, GLU126J, GLU96H, GLY113J, GLY72H, GLY74H, GLY89H, HIS76H, ILE103H, ILE110J, ILE117J, ILE67H, LEU109H, LEU112J, LEU75H, LYS111J, LYS116J, LYS70H, LYS98H, MET114J, PHE107H, PHE122J, PRO123J, PRO124J, SER105H, SER79H, SER80H, SER90H, THR118J, THR77H, THR87H, THR92H, THR99H, TRP83H, TRP95H, TYR101H, TYR82H, VAL104H, VAL120J, VAL93H
• H-K: ALA110H, ALA115K, ALA65H, ALA73H, ARG125K, ASN38H, ASN39H, ASN71H, ASP121K, ASP35H, CYS48H, GLN119K, GLN33H, GLN43H, GLN56H, GLN69H, GLU126K, GLU46H, GLY113K, GLY42H, HIS34H, ILE110K, ILE117K, ILE127K, ILE62H, ILE67H, LEU109H, LEU112K, LEU49H, LEU52H, LYS111K, LYS116K, LYS54H, LYS57H, LYS60H, MET114K, PHE122K, PRO123K, PRO124K, PRO58H, THR118K, THR41H, THR50H, THR53H, THR64H, TRP40H, TYR32H, TYR59H, TYR61H, VAL111H, VAL120K, VAL37H, VAL45H, VAL51H, VAL63H
• H-L: ARG125L, ASN38H, ASN39H, ASP121L, GLN119L, GLN56H, GLU46H, GLY42H, HIS34H, ILE117L, LYS54H, MET114L, PRO123L, THR50H, THR53H
• K-L: ALA115K, ALA115L, ARG125K, ARG125L, ASP121K, ASP121L, GLN119K, GLN119L, GLY113K, GLY113L, ILE117K, ILE117L, LYS116K, LYS116L, MET114K, MET114L, PHE122K, PHE122L, PRO123K, PRO123L, THR118K, THR118L, VAL120K, VAL120L