2PFF

structural insights of yeast fatty acid synthase

• Total interactions analyzed: 36
• Total true interactions: 12
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 140
  • Norm. En. per Res.: -1.151
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-2.6187	0.0	-158.516	-161.1347	140	8	0	10134	0	0	0
A-D	0.0	0.0	-41.671	-41.671	101	11	0	3383	0	0	0
A-G	-3.3424	0.0			2
B-C	-17.0101	0.0	-116.048	-133.0581	126	23	0	8594	0	0	0
B-E	-18.3203	0.0	-47.3634	-65.6837	71	13	0	3245	0	0	0
B-H	-6.2443	0.0			2
C-E	0.0	0.0	-36.241	-36.241	34	5	0	2296	0	0	0
D-E	0.0	0.0	-153.32	-153.32	134	15	0	10264	0	0	0
D-G	-3.4095	0.0			2
E-F	-35.7149	0.0			8
G-H	-2.8153	0.0			2
H-I	-34.255	0.0			8

Interface residues

• A-B: ALA1091A, ALA1684A, ALA956A, ALA975A, ALA976A, ALA978A, ALA986A, ARG954A, ARG985A, ASN1066A, ASN1690A, ASN969A, ASN971A, ASN987A, ASP1077A, ASP974A, GLN989A, GLU1048A, GLU1681A, GLU949A, GLU952A, GLU960A, GLU964A, GLY1065A, GLY1074A, GLY1691A, GLY970A, HIS1063A, HIS1689A, HIS965A, ILE1693A, ILE988A, LEU1047A, LEU1067A, LEU963A, LEU990A, LEU995A, LYS1090A, LYS1682A, LYS1686A, LYS945A, LYS966A, MET1692A, PHE1687A, PHE1688A, PRO984A, SER1678A, SER1683A, SER951A, SER958A, THR1073A, THR950A, THR961A, TRP1075A, TYR1062A, TYR1685A, TYR1694A, TYR977A, UNK1439B, UNK1440B, UNK1441B, UNK1442B, UNK1443B, UNK1444B, UNK1445B, UNK1446B, UNK1447B, UNK1448B, UNK1449B, UNK1450B, UNK1451B, UNK1482B, UNK1483B, UNK1509B, UNK1511B, UNK1512B, UNK1513B, UNK1514B, UNK1515B, UNK1516B, UNK1517B, UNK1518B, UNK1519B, UNK1520B, UNK1521B, UNK1522B, UNK1523B, UNK1524B, UNK1525B, UNK1526B, UNK890B, UNK891B, UNK892B, UNK893B, UNK894B, UNK896B, UNK927B, UNK928B, UNK929B, UNK930B, UNK931B, UNK932B, UNK933B, UNK934B, UNK935B, UNK936B, UNK937B, UNK938B, UNK939B, UNK940B, UNK941B, UNK942B, UNK943B, UNK944B, UNK962B, UNK963B, UNK964B, UNK965B, UNK966B, UNK967B, UNK968B, UNK969B, UNK970B, UNK971B, UNK972B, UNK973B, UNK974B, UNK975B, UNK976B, UNK977B, UNK978B, UNK979B, UNK981B, UNK982B, UNK983B, VAL948A, VAL953A, VAL957A, VAL967A, VAL968A
• A-D: ALA1141D, ASN1272D, ASP1153D, ASP1203D, ASP1267D, ASP1273D, GLN1143D, GLN1207D, GLN1271D, GLN1276D, GLU1139D, GLU1142D, GLU1159D, GLU1162D, GLU1268D, GLY1161D, HIS1146D, ILE1157D, ILE1274D, LEU1167D, LYS1138D, LYS1166D, PHE1134D, PRO1133D, PRO1158D, PRO1269D, SER1164D, SER1206D, THR1140D, THR1160D, TYR1163D, UNK160A, UNK161A, UNK162A, UNK177A, UNK178A, UNK180A, UNK181A, UNK182A, UNK185A, UNK186A, UNK189A, UNK222A, UNK225A, UNK226A, UNK227A, UNK228A, UNK229A, UNK230A, UNK231A, UNK232A, UNK233A, UNK234A, UNK239A, UNK240A, UNK241A, UNK242A, UNK243A, UNK244A, UNK245A, UNK246A, UNK360A, UNK360D, UNK361A, UNK361D, UNK362D, UNK363A, UNK363D, UNK364A, UNK364D, UNK365A, UNK365D, UNK366A, UNK366D, UNK367A, UNK368A, UNK368D, UNK369A, UNK369D, UNK370D, UNK371A, UNK372A, UNK372D, UNK373A, UNK373D, UNK376A, UNK376D, UNK379A, UNK380D, UNK385A, UNK389A, UNK394A, UNK395A, UNK396A, UNK397A, UNK398A, UNK399A, UNK400A, UNK401A, UNK403A, VAL1165D
• A-G: GLN1143A, UNK229G
• B-C: ALA1788B, ALA1805B, ALA1813B, ASN1890B, ASN1892B, ASP1791B, GLN1669B, GLN1672B, GLU1673B, GLU1785B, GLU1811B, GLU1887B, GLY1670B, GLY1677B, GLY1796B, GLY1806B, GLY1810B, GLY1883B, HIS1807B, ILE1798B, ILE1888B, LEU1781B, LEU1792B, LEU1797B, LEU1818B, LEU1885B, LYS1786B, LYS1795B, MET1676B, MET1784B, PHE1789B, PHE1804B, PRO1799B, SER1671B, SER1808B, THR1803B, TRP1884B, TYR1891B, UNK10C, UNK11C, UNK12C, UNK13C, UNK14C, UNK1534B, UNK1535B, UNK1536B, UNK1537B, UNK1538B, UNK1539B, UNK1540B, UNK1541B, UNK15C, UNK1629B, UNK1630B, UNK1631B, UNK1632B, UNK1659B, UNK1660B, UNK1661B, UNK1662B, UNK1663B, UNK1664B, UNK1665B, UNK1666B, UNK1667B, UNK1668B, UNK16C, UNK17C, UNK18C, UNK1958B, UNK1988B, UNK1989B, UNK1990B, UNK1991B, UNK1992B, UNK1993B, UNK1994B, UNK1995B, UNK1996B, UNK19C, UNK1C, UNK2047B, UNK2049B, UNK2050B, UNK2051B, UNK20C, UNK21C, UNK22C, UNK23C, UNK24C, UNK25C, UNK26C, UNK27C, UNK28C, UNK29C, UNK2C, UNK31C, UNK32C, UNK33C, UNK34C, UNK35C, UNK3C, UNK44C, UNK45C, UNK46C, UNK47C, UNK48C, UNK4C, UNK50C, UNK55C, UNK56C, UNK57C, UNK58C, UNK59C, UNK5C, UNK60C, UNK61C, UNK62C, UNK64C, UNK65C, UNK6C, UNK7C, UNK8C, UNK9C, VAL1886B, VAL1889B
• B-E: ALA313E, ALA362E, ASN316E, ASP2B, GLN32E, GLN384E, GLN79E, GLU17B, GLU17E, GLU312E, GLY363E, HIS13B, ILE323E, LEU16B, LEU16E, LEU20B, LEU20E, LEU21E, LEU319E, LEU431E, LYS207E, LYS364E, PHE27E, PHE28E, PRO23E, PRO315E, PRO320E, PRO321E, PRO361E, PRO382E, PRO383E, PRO434E, PRO8B, SER15B, SER318E, SER322E, THR210E, THR24E, THR317E, TYR230E, TYR311E, TYR314E, UNK1296B, UNK1297B, UNK1298B, UNK1300B, UNK1301B, UNK1303B, UNK1304B, UNK1305B, UNK1306B, UNK1307B, UNK1308B, UNK1309B, UNK1310B, UNK1311B, UNK1312B, UNK1313B, UNK1314B, UNK1551B, UNK1556B, UNK1560B, UNK1594B, UNK1596B, UNK1597B, UNK1598B, UNK1599B, UNK1600B, UNK1601B, UNK1602B, VAL19B
• B-H: SER318B, UNK1305H
• C-E: ARG394E, ASN357E, ASN390E, ASP326E, GLN384E, GLY388E, HIS359E, ILE323E, LEU360E, LEU386E, LEU389E, LEU391E, LEU393E, LYS355E, LYS364E, LYS395E, PRO320E, PRO361E, SER322E, SER358E, SER385E, THR356E, THR392E, TYR387E, UNK34C, UNK37C, UNK38C, UNK39C, UNK40C, UNK41C, UNK42C, UNK43C, UNK44C, UNK45C
• D-E: ALA1091D, ALA1684D, ALA956D, ALA975D, ALA976D, ALA978D, ALA986D, ARG985D, ASN1066D, ASN1690D, ASN969D, ASN987D, ASP1077D, ASP974D, GLN989D, GLU1048D, GLU1681D, GLU949D, GLU952D, GLU960D, GLU964D, GLY1065D, GLY1074D, GLY1691D, GLY970D, HIS1063D, HIS1689D, HIS965D, ILE1693D, ILE988D, LEU1047D, LEU1067D, LEU963D, LEU990D, LEU995D, LYS1068D, LYS1090D, LYS1682D, LYS1686D, LYS945D, LYS966D, MET1692D, PHE1687D, PHE1688D, PRO984D, SER1046D, SER1678D, SER1683D, THR1073D, THR950D, THR961D, TRP1075D, TYR1062D, TYR1685D, TYR1694D, TYR977D, UNK1439E, UNK1440E, UNK1441E, UNK1442E, UNK1443E, UNK1444E, UNK1445E, UNK1446E, UNK1447E, UNK1448E, UNK1449E, UNK1450E, UNK1483E, UNK1511E, UNK1512E, UNK1513E, UNK1514E, UNK1515E, UNK1516E, UNK1517E, UNK1518E, UNK1519E, UNK1520E, UNK1521E, UNK1522E, UNK1524E, UNK1525E, UNK890E, UNK891E, UNK892E, UNK893E, UNK894E, UNK896E, UNK927E, UNK928E, UNK929E, UNK930E, UNK931E, UNK932E, UNK933E, UNK934E, UNK935E, UNK936E, UNK937E, UNK938E, UNK939E, UNK940E, UNK941E, UNK942E, UNK943E, UNK944E, UNK962E, UNK963E, UNK964E, UNK965E, UNK966E, UNK967E, UNK968E, UNK969E, UNK970E, UNK971E, UNK972E, UNK973E, UNK974E, UNK975E, UNK976E, UNK977E, UNK978E, UNK979E, UNK981E, UNK982E, UNK983E, VAL1076D, VAL948D, VAL953D, VAL957D, VAL967D, VAL968D
• D-G: GLN1143G, UNK229D
• E-F: LEU1885E, UNK1661E, UNK1663E, UNK16F, UNK18F, UNK1F, UNK2051E, UNK3F
• G-H: UNK1514H, VAL968G
• H-I: LEU1885H, UNK1661H, UNK1663H, UNK16I, UNK18I, UNK1I, UNK2051H, UNK3I