2PBI

the multifunctional nature of gbeta5/rgs9 revealed from its crystal structure

• Total interactions analyzed: 6
• Total true interactions: 4
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 385
  • Norm. En. per Res.: -3.9328
• Hub Node: B(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-144.4967	-113.3808	-1183.31	-1441.1875	380	32	36	46945	14	113	99
B-C	0.0	10.7036	-15.9535	-5.2499	14	0	0	614	0	2	4
B-D	0.0	-8.1188	-0.2165	-8.3353	5	0	0	63	0	3	0
C-D	-163.8857	-127.3001	-1222.93	-1514.1158	385	39	37	47919	14	117	101

Interface residues

• A-B: ALA13B, ALA15A, ALA196B, ALA19B, ALA204B, ALA221A, ALA22A, ALA232A, ALA234B, ALA253B, ALA259A, ALA261B, ALA270B, ALA275B, ALA282A, ALA31B, ALA339B, ALA353B, ALA387A, ALA42B, ALA70A, ARG11A, ARG13A, ARG207A, ARG223A, ARG227B, ARG235A, ARG264B, ARG269B, ARG272B, ARG292A, ARG295A, ARG296B, ARG305A, ARG30B, ARG317B, ARG327B, ARG332B, ARG382A, ARG44B, ARG56B, ARG57B, ARG62A, ARG76B, ARG77B, ASN127B, ASN154B, ASN163B, ASN198A, ASN199A, ASN210A, ASN210B, ASN243B, ASN257A, ASN268A, ASN281A, ASN299A, ASN303B, ASN308B, ASN326B, ASN64B, ASN67A, ASN72A, ASN75A, ASN9B, ASP126B, ASP165B, ASP174B, ASP181B, ASP197B, ASP202A, ASP206A, ASP218B, ASP225B, ASP241B, ASP252B, ASP258A, ASP259B, ASP260B, ASP267B, ASP271B, ASP273A, ASP274A, ASP279A, ASP304B, ASP334A, ASP336B, ASP339A, ASP346B, ASP35B, ASP386A, ASP74B, ASP91B, CYS217B, CYS231B, CYS264A, CYS341B, GLN112A, GLN167B, GLN186B, GLN189B, GLN18A, GLN217A, GLN230A, GLN230B, GLN231A, GLN233B, GLN253A, GLN276A, GLN340A, GLN389A, GLN40B, GLN50B, GLN71A, GLN83B, GLN8A, GLN9A, GLU10B, GLU183B, GLU18B, GLU207B, GLU20B, GLU21A, GLU225A, GLU236B, GLU239B, GLU252A, GLU273B, GLU27B, GLU280B, GLU28B, GLU29B, GLU302A, GLU325B, GLU333A, GLU37B, GLU43B, GLU46B, GLU69A, GLY124B, GLY173B, GLY175B, GLY185B, GLY193B, GLY195B, GLY204A, GLY209B, GLY216B, GLY229B, GLY245A, GLY246A, GLY24B, GLY251B, GLY263A, GLY285B, GLY295B, GLY323B, GLY337B, GLY338A, GLY376A, GLY49B, GLY74A, GLY7A, HIS192B, HIS194B, HIS324B, HIS34B, HIS381A, HIS39B, ILE20A, ILE226A, ILE247A, ILE260A, ILE271A, ILE282B, ILE283B, ILE304A, ILE307B, ILE320B, ILE372A, ILE59A, ILE65A, ILE77A, ILE78B, LEU125B, LEU12B, LEU156B, LEU15B, LEU169B, LEU179B, LEU17A, LEU187B, LEU188B, LEU199B, LEU201A, LEU203B, LEU205A, LEU22B, LEU233A, LEU23A, LEU244A, LEU265B, LEU268B, LEU26B, LEU280A, LEU293B, LEU297B, LEU313B, LEU321B, LEU331B, LEU335A, LEU33B, LEU385A, LEU38B, LEU48B, LEU59B, LEU63A, LEU67B, LEU68A, LEU73A, LYS16B, LYS19A, LYS215A, LYS216A, LYS219B, LYS220B, LYS224A, LYS239A, LYS23B, LYS249A, LYS25B, LYS279B, LYS283A, LYS314B, LYS32B, LYS336A, LYS342A, LYS346A, LYS397A, LYS54B, LYS65B, LYS73B, LYS75B, LYS79A, MET109B, MET14A, MET166B, MET222B, MET226B, MET227A, MET234A, MET261A, MET394A, MET53B, PHE16A, PHE191B, PHE235B, PHE254A, PHE254B, PHE277A, PHE284B, PHE291B, PHE298A, PHE299B, PHE300A, PHE322B, PHE340B, PHE51B, PHE76A, PHE93B, PRO115B, PRO12A, PRO205B, PRO211A, PRO249B, PRO269A, PRO335B, SER116B, SER14B, SER157B, SER164B, SER172B, SER17B, SER184B, SER190B, SER206B, SER21B, SER228B, SER236A, SER240A, SER240B, SER241A, SER243A, SER250B, SER251A, SER255A, SER256A, SER258B, SER262A, SER267A, SER278B, SER281B, SER292B, SER294B, SER301A, SER334B, SER341A, SER66A, SER92B, THR106B, THR11B, THR153B, THR162B, THR208B, THR209A, THR211B, THR218A, THR220A, THR237A, THR262B, THR272A, THR275A, THR306B, THR338B, THR390A, THR55B, THR60A, THR94B, THR95B, TRP107B, TRP180B, TRP224B, TRP270A, TRP278A, TRP329A, TRP345B, TRP352B, TRP64A, TRP71B, TYR10A, TYR155B, TYR203A, TYR228A, TYR229A, TYR248B, TYR250A, TYR266B, TYR277B, TYR302B, TYR305B, TYR337A, TYR383A, TYR393A, TYR80A, TYR82A, VAL182B, VAL198B, VAL200A, VAL208A, VAL219A, VAL222A, VAL223B, VAL232B, VAL238A, VAL242A, VAL242B, VAL248A, VAL24A, VAL274B, VAL309B, VAL312B, VAL318B, VAL333B, VAL343A, VAL351B, VAL36B, VAL384A, VAL41B, VAL45B, VAL52B
• B-C: ALA13B, ASN9B, ASP273C, ASP274C, GLU10B, ILE271C, LEU12B, PRO269C, SER14B, SER267C, THR11B, THR272C, THR275C, TRP270C
• B-D: ARG56D, ARG57D, GLU10B, PHE93D, THR11B
• C-D: ALA13D, ALA15C, ALA196D, ALA19D, ALA204D, ALA221C, ALA22C, ALA232C, ALA234D, ALA253D, ALA259C, ALA261D, ALA270D, ALA275D, ALA282C, ALA31D, ALA339D, ALA353D, ALA387C, ALA42D, ALA70C, ARG11C, ARG13C, ARG207C, ARG223C, ARG227D, ARG235C, ARG264D, ARG269D, ARG272D, ARG292C, ARG295C, ARG296D, ARG305C, ARG30D, ARG317D, ARG327D, ARG332D, ARG382C, ARG44D, ARG56D, ARG57D, ARG62C, ARG76D, ARG77D, ASN127D, ASN154D, ASN163D, ASN198C, ASN199C, ASN210C, ASN210D, ASN243D, ASN257C, ASN268C, ASN281C, ASN299C, ASN303D, ASN308D, ASN326D, ASN64D, ASN67C, ASN72C, ASN75C, ASP126D, ASP165D, ASP174D, ASP181D, ASP197D, ASP202C, ASP206C, ASP218D, ASP225D, ASP241D, ASP252D, ASP258C, ASP259D, ASP260D, ASP267D, ASP271D, ASP273C, ASP274C, ASP279C, ASP304D, ASP311D, ASP334C, ASP336D, ASP339C, ASP346D, ASP35D, ASP386C, ASP74D, ASP91D, CYS217D, CYS231D, CYS264C, CYS341D, GLN112C, GLN167D, GLN186D, GLN189D, GLN18C, GLN217C, GLN230C, GLN230D, GLN231C, GLN233D, GLN253C, GLN276C, GLN340C, GLN389C, GLN40D, GLN71C, GLN83D, GLN8C, GLN9C, GLU10D, GLU183D, GLU18D, GLU207D, GLU20D, GLU213C, GLU21C, GLU225C, GLU236D, GLU239D, GLU252C, GLU273D, GLU27D, GLU280D, GLU28D, GLU29D, GLU302C, GLU325D, GLU333C, GLU37D, GLU43D, GLU46D, GLU69C, GLY124D, GLY173D, GLY175D, GLY193D, GLY195D, GLY204C, GLY209D, GLY216D, GLY229D, GLY245C, GLY246C, GLY24D, GLY251D, GLY263C, GLY285D, GLY295D, GLY323D, GLY337D, GLY338C, GLY376C, GLY49D, GLY74C, GLY7C, HIS192D, HIS194D, HIS324D, HIS347D, HIS34D, HIS379C, HIS381C, HIS391C, HIS39D, ILE20C, ILE226C, ILE247C, ILE260C, ILE271C, ILE282D, ILE283D, ILE304C, ILE307D, ILE320D, ILE372C, ILE59C, ILE65C, ILE77C, ILE78D, LEU125D, LEU12D, LEU156D, LEU15D, LEU169D, LEU179D, LEU17C, LEU187D, LEU188D, LEU199D, LEU201C, LEU203D, LEU205C, LEU22D, LEU233C, LEU23C, LEU244C, LEU265D, LEU268D, LEU26D, LEU280C, LEU293D, LEU297D, LEU313D, LEU321D, LEU331D, LEU335C, LEU33D, LEU385C, LEU38D, LEU48D, LEU59D, LEU63C, LEU67D, LEU68C, LEU73C, LYS16D, LYS19C, LYS215C, LYS216C, LYS219D, LYS220D, LYS224C, LYS239C, LYS23D, LYS249C, LYS25D, LYS279D, LYS283C, LYS314D, LYS32D, LYS336C, LYS342C, LYS346C, LYS397C, LYS54D, LYS65D, LYS73D, LYS75D, LYS79C, MET109D, MET14C, MET166D, MET222D, MET226D, MET227C, MET234C, MET261C, MET291C, MET394C, MET53D, PHE16C, PHE191D, PHE212D, PHE235D, PHE254C, PHE254D, PHE277C, PHE284D, PHE291D, PHE298C, PHE299D, PHE300C, PHE322D, PHE340D, PHE51D, PHE76C, PHE93D, PRO115D, PRO12C, PRO205D, PRO211C, PRO249D, PRO269C, PRO335D, SER116D, SER14D, SER157D, SER164D, SER172D, SER17D, SER184D, SER190D, SER206D, SER21D, SER228D, SER236C, SER240C, SER240D, SER241C, SER243C, SER250D, SER251C, SER255C, SER256C, SER258D, SER262C, SER267C, SER278D, SER281D, SER292D, SER294D, SER301C, SER334D, SER341C, SER66C, SER92D, THR106D, THR11D, THR153D, THR162D, THR208D, THR209C, THR211D, THR218C, THR220C, THR237C, THR262D, THR272C, THR275C, THR306D, THR338D, THR390C, THR55D, THR60C, THR94D, THR95D, TRP107D, TRP180D, TRP224D, TRP270C, TRP278C, TRP329C, TRP345D, TRP352D, TRP64C, TRP71D, TYR10C, TYR155D, TYR203C, TYR228C, TYR229C, TYR248D, TYR250C, TYR266D, TYR277D, TYR302D, TYR305D, TYR337C, TYR383C, TYR393C, TYR80C, TYR82C, VAL108D, VAL182D, VAL198D, VAL200C, VAL208C, VAL219C, VAL222C, VAL223D, VAL232D, VAL238C, VAL242C, VAL242D, VAL248C, VAL24C, VAL274D, VAL309D, VAL312D, VAL318D, VAL333D, VAL343C, VAL351D, VAL36D, VAL384C, VAL41D, VAL45D, VAL52D