2P6A

the structure of the activin:follistatin 315 complex

• Total interactions analyzed: 10
• Total true interactions: 9
• Strongest Interaction:
  • Chains: D-C
  • Int. Res.: 82
  • Norm. En. per Res.: -3.7846
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	-50.7345	-35.003	-241.954	-327.6915	157	28	7	12642	2	46	36
A-B	-27.4237	-12.7609	-215.876	-256.0606	132	33	9	13285	0	26	20
A-C	0.0	-3.0582	-60.1231	-63.1813	32	4	1	2606	0	6	4
D-B	0.0	-3.5834	-56.5491	-60.1325	35	7	3	3202	0	6	4
D-C	-73.8695	-109.8454	-126.626	-310.341	82	35	0	5384	5	30	15
D-E	0.0	0.0	-0.1131	-0.1131	4	0	1	32	0	0	0
B-C	-50.3246	-59.2261	-205.691	-315.2417	165	50	8	12822	2	50	34
B-E	0.0	0.0	-9.7174	-9.7174	16	0	1	760	0	0	0
C-E	0.0	0.0	-38.0016	-38.0016	41	3	4	2162	0	0	0

Interface residues

• A-D: ALA158D, ALA188D, ALA194D, ALA205D, ALA31A, ALA37A, ALA49A, ARG120D, ARG192D, ARG200D, ARG237D, ARG31D, ARG6D, ARG87A, ASN156D, ASN157D, ASN164D, ASN180D, ASN26A, ASN38A, ASN42D, ASN44D, ASN64A, ASN99A, ASN9A, ASP104A, ASP106D, ASP153D, ASP27A, ASP43D, ASP5A, ASP95A, ASP96A, CYS12A, CYS135D, CYS150D, CYS160D, CYS163D, CYS189D, CYS196D, CYS238D, CYS3D, GLN124D, GLN130D, GLN14D, GLN154D, GLN15A, GLN98A, GLU111A, GLU112A, GLU123D, GLU126D, GLU128D, GLU297D, GLU298D, GLU299D, GLU3A, GLY104D, GLY107D, GLY179D, GLY199D, GLY1A, GLY203D, GLY24A, GLY34A, GLY50A, GLY53A, GLY54D, GLY55D, GLY6A, GLY97A, HIS36A, HIS47A, HIS59A, HIS65A, ILE100A, ILE101A, ILE109A, ILE10A, ILE166D, ILE202D, ILE29A, ILE30A, ILE48A, ILE51D, LEU105D, LEU127D, LEU16D, LEU177D, LEU191D, LEU197D, LEU198D, LEU204D, LEU240D, LEU2A, LEU32D, LEU46D, LEU5D, LEU92A, LYS102A, LYS103A, LYS108D, LYS122D, LYS18D, LYS193D, LYS21A, LYS225D, LYS48D, LYS7A, MET108A, MET50D, MET68A, MET89A, MET91A, PHE16A, PHE17A, PHE20A, PHE47D, PHE58A, PRO125D, PRO32A, PRO45A, PRO88A, SER187D, SER19A, SER201D, SER239D, SER33A, SER46A, SER52A, SER54A, SER57A, SER60A, SER90A, THR149D, THR155D, THR162D, THR195D, THR19D, THR29D, THR51A, THR61A, TRP25A, TRP28A, TRP4D, TYR159D, TYR17D, TYR35A, TYR93A, TYR94A, VAL151D, VAL152D, VAL15D, VAL161D, VAL18A, VAL62A, VAL8A
• A-B: ALA37A, ALA37B, ARG67A, ARG69A, ARG69B, ARG87A, ASN107A, ASN107B, ASN38A, ASN38B, ASN64A, ASN76A, ASN76B, ASP22A, ASP22B, CYS113A, CYS115A, CYS115B, CYS40A, CYS40B, CYS44B, CYS80A, CYS80B, CYS81A, CYS81B, GLN106A, GLN106B, GLN15A, GLU111A, GLU112A, GLU41A, GLU41B, GLY114A, GLY114B, GLY24A, GLY24B, GLY34A, GLY42A, GLY42B, GLY50B, GLY53A, GLY53B, HIS36A, HIS36B, HIS59A, HIS59B, HIS65A, HIS65B, HIS71A, HIS71B, ILE105A, ILE105B, ILE109A, ILE109B, ILE23A, ILE23B, ILE29A, ILE29B, ILE63A, ILE63B, LEU56A, LEU56B, LEU77A, LEU77B, LEU86A, LEU86B, LYS14A, LYS14B, LYS21B, LYS78A, LYS78B, LYS85A, LYS85B, MET108A, MET108B, MET68A, MET68B, MET89A, MET89B, MET91A, MET91B, PHE16A, PHE16B, PHE17A, PHE17B, PHE20A, PHE20B, PHE58A, PHE58B, PHE74A, PHE74B, PRO73A, PRO73B, PRO83A, PRO83B, SER116A, SER116B, SER19A, SER19B, SER54A, SER54B, SER55A, SER55B, SER57A, SER57B, SER60A, SER60B, SER72B, SER79A, SER79B, THR61A, THR61B, THR84A, THR84B, TRP25A, TRP25B, TRP28A, TRP28B, TYR35A, TYR35B, TYR39A, TYR39B, TYR66A, TYR66B, VAL110A, VAL110B, VAL18A, VAL18B, VAL62A, VAL62B, VAL82A, VAL82B
• A-C: ASN44C, ASN53C, ASN99A, ASP104A, ASP27A, ASP95A, ASP96A, GLN106A, GLN98A, GLY24A, GLY54C, GLY97A, ILE101A, ILE105A, ILE23A, ILE29A, ILE51C, LYS103A, LYS48C, MET108A, MET50C, MET91A, PHE47C, PHE52C, PRO57C, THR45C, TRP25A, TRP28A, TRP49C, TYR35A, TYR93A, TYR94A
• D-B: ARG12D, ASN44D, ASN53D, ASN99B, ASP104B, ASP27B, ASP95B, ASP96B, GLN106B, GLN98B, GLU39D, GLY24B, GLY54D, GLY97B, ILE101B, ILE105B, ILE23B, ILE29B, ILE30B, ILE51D, LEU92B, LYS103B, LYS48D, MET108B, MET50D, MET91B, PHE47D, PHE52D, PRO57D, THR45D, TRP25B, TRP28B, TRP49D, TYR93B, TYR94B
• D-C: ALA56C, ALA56D, ALA8C, ALA8D, ARG12C, ARG12D, ARG192C, ARG192D, ASN10C, ASN10D, ASN44D, ASN53C, ASN53D, ASN58C, ASN58D, ASP242C, ASP242D, ASP247C, ASP247D, ASP40D, CYS13C, CYS13D, CYS241C, CYS241D, CYS245C, CYS245D, CYS266C, CYS266D, CYS59C, CYS59D, GLN7C, GLN7D, GLU207C, GLU243C, GLU243D, GLU265C, GLU38C, GLU38D, GLU39C, GLU39D, GLY11C, GLY11D, GLY223C, GLY223D, GLY224C, GLY224D, GLY54C, GLY54D, GLY55C, GLY55D, ILE60C, ILE60D, LEU240C, LEU240D, LEU244C, LEU244D, LYS225C, LYS225D, LYS226C, LYS269C, LYS269D, LYS48C, LYS48D, LYS82C, LYS82D, LYS84C, LYS84D, LYS9C, LYS9D, PHE52C, PRO246C, PRO246D, PRO57C, PRO57D, PRO61C, PRO61D, SER239D, THR222C, THR222D, THR37D, TRP49C, TRP49D
• D-E: ALA8E, ALA9E, ASN53D, PHE52D
• B-C: ALA158C, ALA188C, ALA194C, ALA205C, ALA31B, ALA37B, ALA49B, ALA56C, ARG120C, ARG165C, ARG192C, ARG200C, ARG237C, ARG31C, ARG69B, ARG6C, ARG87B, ASN156C, ASN157C, ASN164C, ASN180C, ASN26B, ASN2C, ASN38B, ASN42C, ASN44C, ASN64B, ASN99B, ASN9B, ASP104B, ASP106C, ASP153C, ASP27B, ASP43C, ASP5B, ASP70C, ASP95B, ASP96B, CYS113B, CYS12B, CYS13C, CYS160C, CYS163C, CYS167C, CYS189C, CYS196C, CYS238C, CYS3C, CYS4B, CYS71C, GLN124C, GLN130C, GLN14C, GLN154C, GLN15B, GLN98B, GLU111B, GLU112B, GLU123C, GLU126C, GLU128C, GLU3B, GLY107C, GLY179C, GLY199C, GLY1B, GLY203C, GLY223C, GLY24B, GLY34B, GLY50B, GLY53B, GLY54C, GLY55C, GLY6B, GLY72C, GLY97B, HIS190C, HIS36B, HIS47B, HIS59B, HIS65B, ILE100B, ILE101B, ILE109B, ILE10B, ILE166C, ILE202C, ILE29B, ILE30B, ILE48B, ILE51C, ILE63B, LEU105C, LEU127C, LEU16C, LEU177C, LEU191C, LEU197C, LEU204C, LEU240C, LEU2B, LEU46C, LEU5C, LEU92B, LYS102B, LYS103B, LYS108C, LYS122C, LYS18C, LYS193C, LYS21B, LYS225C, LYS48C, LYS7B, MET108B, MET50C, MET68B, MET89B, MET91B, PHE16B, PHE17B, PHE20B, PHE47C, PHE58B, PRO125C, PRO32B, PRO45B, PRO88B, SER187C, SER201C, SER239C, SER33B, SER46B, SER52B, SER54B, SER55B, SER57B, SER60B, SER90B, THR155C, THR162C, THR195C, THR19C, THR29C, THR51B, THR61B, TRP25B, TRP28B, TRP49C, TRP4C, TYR159C, TYR17C, TYR206C, TYR35B, TYR93B, TYR94B, VAL151C, VAL152C, VAL15C, VAL161C, VAL18B, VAL41C, VAL62B, VAL8B
• B-E: ALA10E, ALA5E, ALA6E, ALA7E, ALA8E, ALA9E, ASN99B, ASP95B, ASP96B, GLN98B, GLY97B, ILE100B, ILE101B, LYS102B, LYS103B, TYR93B
• C-E: ALA10E, ALA2E, ALA3E, ALA4E, ALA5E, ALA6E, ALA7E, ALA8E, ALA9E, ARG200C, ARG237C, ASN156C, ASN180C, ASP230C, ASP251C, CYS266C, GLN154C, GLU243C, GLU252C, GLU265C, GLU280C, GLY203C, HIS283C, ILE202C, LEU198C, LEU228C, LEU240C, LEU278C, LEU279C, LYS232C, LYS269C, LYS282C, SER201C, SER239C, SER250C, SER257C, SER264C, THR138C, THR155C, VAL254C, VAL281C