2P1B

crystal structure of human nucleophosmin-core

• Total interactions analyzed: 45
• Total true interactions: 30
• Strongest Interaction:
  • Chains: A-E
  • Int. Res.: 102
  • Norm. En. per Res.: -3.6829
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-8.2295	-13.5859	-268.042	-289.8574	100	22	9	11874	0	14	16
A-C	0.0	0.0	-0.003	-0.003	4	0	0	5	0	0	0
A-D	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
A-E	-70.8583	-11.2977	-293.503	-375.659	102	27	8	12079	0	14	14
A-F	-19.996	-5.457	-19.4858	-44.9388	17	2	0	1097	2	12	10
A-G	0.0	0.0	-0.0545	-0.0545	2	0	0	22	0	2	1
B-C	-40.6644	-7.273	-283.672	-331.6094	104	20	11	12120	0	13	15
B-D	0.0	0.0	-0.0022	-0.0022	4	0	0	2	0	0	0
B-E	0.0	0.0	-0.0019	-0.0019	4	0	0	2	0	0	0
B-G	-28.2229	-16.379	-15.1024	-59.7043	17	4	0	1007	2	12	10
B-H	0.0	0.0	-0.1324	-0.1324	2	0	0	27	0	4	1
C-D	-29.3724	-11.5158	-290.767	-331.6552	105	20	9	12427	0	14	15
C-E	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	0
C-H	-24.6915	-13.2248	-22.8014	-60.7177	20	2	0	1276	3	12	10
C-I	0.0	0.0	-0.1144	-0.1144	2	0	0	27	0	4	1
D-E	-18.4886	-15.4883	-286.293	-320.2698	103	27	10	12289	0	14	16
D-I	-33.719	-14.6255	-18.9623	-67.3068	20	3	0	1225	2	12	10
D-J	0.0	0.0	-0.2003	-0.2003	2	0	0	38	0	4	1
E-F	0.0	0.0	-0.0889	-0.0889	2	0	0	31	0	2	1
E-J	-25.8644	-10.9276	-18.4217	-55.2137	19	2	0	1045	2	12	10
F-G	-63.4647	-5.7765	-288.797	-358.0382	103	23	10	12129	0	12	15
F-H	0.0	0.0	-0.0022	-0.0022	4	0	0	2	0	0	0
F-I	0.0	0.0	-0.0027	-0.0027	4	0	0	2	0	0	0
F-J	-18.5731	-13.5819	-278.154	-310.309	103	22	11	12125	0	14	16
G-H	-58.4029	-5.3257	-288.019	-351.7476	103	24	11	12439	0	13	17
G-I	0.0	0.0	-0.0044	-0.0044	4	0	0	3	0	0	0
G-J	0.0	0.0	-0.0025	-0.0025	4	0	0	2	0	0	0
H-I	-33.6458	-14.5091	-264.94	-313.0949	102	18	8	11742	0	12	15
H-J	0.0	0.0	-0.0041	-0.0041	4	0	0	5	0	0	0
I-J	-32.5488	-13.78	-301.564	-347.8928	106	28	10	12624	0	13	15

Interface residues

• A-B: ALA118A, ALA51A, ALA53A, ALA62B, ALA64B, ALA77B, ARG45A, ARG45B, ASN16A, ASN66B, ASP34A, CYS104B, CYS21A, GLN114A, GLN15A, GLN41B, GLN84A, GLN84B, GLU22A, GLU61B, GLU63B, GLU68B, GLU93B, GLY113A, GLY20A, GLY50A, GLY52A, GLY69B, GLY90A, GLY90B, GLY91A, GLY91B, HIS110A, HIS115A, HIS40A, HIS40B, HIS58B, ILE111A, ILE59B, ILE72B, ILE94B, LEU100B, LEU116A, LEU18A, LEU42B, LEU44A, LEU44B, LEU49A, LEU57B, LEU76B, LEU79A, LEU79B, LEU89A, LEU89B, LYS103B, LYS32A, LYS73B, LYS80A, LYS80B, MET65B, MET81A, PHE19A, PHE31A, PHE92B, PRO108A, PRO71B, PRO85A, PRO85B, PRO96B, PRO97B, SER112A, SER43A, SER43B, SER48A, SER82A, SER82B, SER88A, SER88B, THR46A, THR75B, THR78B, THR86A, THR86B, THR95B, TYR17A, TYR29A, TYR67B, VAL109A, VAL117A, VAL33A, VAL47A, VAL47B, VAL60B, VAL74B, VAL83A, VAL83B, VAL87A, VAL87B, VAL98B, VAL99B
• A-C: GLN84A, GLN84C, VAL83A, VAL83C
• A-D: GLN84A, GLN84D
• A-E: ALA118E, ALA51E, ALA53E, ALA62A, ALA64A, ALA77A, ARG45A, ARG45E, ASN16E, ASN66A, ASP34E, ASP55E, CYS104A, CYS21E, GLN114E, GLN15E, GLN41A, GLN84A, GLN84E, GLU22E, GLU39E, GLU61A, GLU63A, GLU68A, GLU93A, GLY105A, GLY113E, GLY20E, GLY50E, GLY52E, GLY69A, GLY90A, GLY90E, GLY91A, GLY91E, HIS110E, HIS115E, HIS40A, HIS40E, HIS58A, ILE111E, ILE59A, ILE72A, ILE94A, LEU100A, LEU116E, LEU18E, LEU42A, LEU44A, LEU44E, LEU49E, LEU57A, LEU76A, LEU79A, LEU79E, LEU89A, LEU89E, LYS103A, LYS73A, LYS80A, LYS80E, MET65A, MET81E, PHE19E, PHE31E, PHE92A, PRO108E, PRO71A, PRO85E, PRO96A, PRO97A, SER112E, SER43A, SER43E, SER48E, SER70A, SER82A, SER82E, SER88A, SER88E, THR46E, THR75A, THR78A, THR86A, THR86E, THR95A, TYR17E, TYR29E, TYR67A, VAL109E, VAL117E, VAL33E, VAL47A, VAL47E, VAL60A, VAL74A, VAL83A, VAL83E, VAL87A, VAL87E, VAL98A, VAL99A
• A-F: ASP55A, ASP55F, GLU56A, GLU56F, LEU57A, LEU57F, LYS54A, LYS54F, LYS80A, LYS80F, MET81A, MET81F, SER106A, SER82A, SER82F, VAL83A, VAL83F
• A-G: SER82A, SER82G
• B-C: ALA118B, ALA51B, ALA53B, ALA62C, ALA64C, ALA77C, ARG45B, ARG45C, ASN16B, ASN66C, ASP34B, CYS104C, CYS21B, GLN114B, GLN15B, GLN41C, GLN84B, GLN84C, GLU22B, GLU39B, GLU61C, GLU63C, GLU68C, GLU93C, GLY105C, GLY113B, GLY20B, GLY50B, GLY52B, GLY69C, GLY90B, GLY90C, GLY91B, GLY91C, HIS110B, HIS115B, HIS40B, HIS40C, HIS58C, ILE111B, ILE59C, ILE72C, ILE94C, LEU100C, LEU116B, LEU116C, LEU18B, LEU42C, LEU44B, LEU44C, LEU49B, LEU57C, LEU76C, LEU79B, LEU79C, LEU89B, LEU89C, LYS103C, LYS32B, LYS73C, LYS80B, LYS80C, MET65C, MET81B, PHE19B, PHE31B, PHE92C, PRO108B, PRO71C, PRO85B, PRO85C, PRO96C, PRO97C, SER112B, SER43B, SER43C, SER48B, SER70C, SER82B, SER82C, SER88B, SER88C, THR46B, THR75C, THR78C, THR86B, THR86C, THR95C, TYR17B, TYR29B, TYR67C, VAL109B, VAL117B, VAL33B, VAL47B, VAL47C, VAL60C, VAL74C, VAL83B, VAL83C, VAL87B, VAL87C, VAL98C, VAL99C
• B-D: GLN84B, GLN84D, SER88B, SER88D
• B-E: GLN84B, GLN84E, VAL83B, VAL83E
• B-G: ASP55B, ASP55G, GLU56B, GLU56G, LEU57B, LEU57G, LYS54B, LYS54G, LYS80B, LYS80G, MET81B, MET81G, SER106G, SER82B, SER82G, VAL83B, VAL83G
• B-H: SER82B, SER82H
• C-D: ALA118C, ALA51C, ALA53C, ALA62D, ALA64D, ALA77D, ARG45C, ARG45D, ASN16C, ASN66D, ASP34C, CYS104D, CYS21C, GLN114C, GLN15C, GLN41D, GLN84C, GLN84D, GLU22C, GLU39C, GLU39D, GLU61D, GLU63D, GLU68D, GLU93D, GLY113C, GLY20C, GLY50C, GLY52C, GLY69D, GLY90C, GLY90D, GLY91C, GLY91D, HIS110C, HIS115C, HIS40C, HIS40D, HIS58D, ILE111C, ILE59D, ILE72D, ILE94D, LEU100D, LEU116C, LEU18C, LEU42D, LEU44C, LEU44D, LEU49C, LEU57D, LEU76D, LEU79C, LEU79D, LEU89C, LEU89D, LYS103D, LYS32C, LYS73D, LYS80C, LYS80D, MET65D, MET81C, MET81D, PHE19C, PHE31C, PHE92D, PRO108C, PRO71D, PRO85C, PRO85D, PRO96D, PRO97D, SER112C, SER43C, SER43D, SER48C, SER70D, SER82C, SER82D, SER88C, SER88D, THR46C, THR46D, THR75D, THR78D, THR86C, THR86D, THR95D, TYR17C, TYR29C, TYR67D, VAL109C, VAL117C, VAL33C, VAL47C, VAL47D, VAL60D, VAL74D, VAL83C, VAL83D, VAL87C, VAL87D, VAL98D, VAL99D
• C-E: GLN84C, GLN84E
• C-H: ASP55C, ASP55H, GLU56C, GLU56H, GLY105C, GLY105H, LEU57C, LEU57H, LYS54C, LYS54H, LYS80C, LYS80H, MET81C, MET81H, SER106C, SER106H, SER82C, SER82H, VAL83C, VAL83H
• C-I: SER82C, SER82I
• D-E: ALA118D, ALA51D, ALA53D, ALA62E, ALA64E, ALA77E, ARG45D, ARG45E, ASN16D, ASN66E, ASP34D, ASP55D, CYS104E, CYS21D, GLN114D, GLN15D, GLN41E, GLN84D, GLN84E, GLU22D, GLU39D, GLU39E, GLU61E, GLU63E, GLU68E, GLU93E, GLY113D, GLY20D, GLY50D, GLY52D, GLY69E, GLY90D, GLY90E, GLY91D, GLY91E, HIS110D, HIS115D, HIS40D, HIS40E, HIS58E, ILE111D, ILE59E, ILE72E, ILE94E, LEU100E, LEU116D, LEU18D, LEU44D, LEU44E, LEU49D, LEU57E, LEU76E, LEU79D, LEU79E, LEU89D, LEU89E, LYS103E, LYS32D, LYS73E, LYS80D, LYS80E, MET65E, MET81D, MET81E, PHE19D, PHE31D, PHE92E, PRO108D, PRO71E, PRO85D, PRO85E, PRO97E, SER112D, SER43D, SER43E, SER48D, SER70E, SER82D, SER82E, SER88D, SER88E, THR46D, THR75E, THR78E, THR86D, THR86E, THR95E, TYR17D, TYR29D, TYR67E, VAL109D, VAL117D, VAL33D, VAL47D, VAL47E, VAL60E, VAL74E, VAL83D, VAL83E, VAL87D, VAL87E, VAL98E, VAL99E
• D-I: ASP55D, ASP55I, CYS104D, GLU56D, GLU56I, GLY105D, GLY105I, LEU57D, LEU57I, LYS54D, LYS54I, LYS80D, LYS80I, MET81D, MET81I, SER106I, SER82D, SER82I, VAL83D, VAL83I
• D-J: SER82D, SER82J
• E-F: SER82E, SER82F
• E-J: ASP55E, ASP55J, GLU56E, GLU56J, GLY105J, LEU57E, LEU57J, LYS54E, LYS54J, LYS80E, LYS80J, MET81E, MET81J, SER106E, SER106J, SER82E, SER82J, VAL83E, VAL83J
• F-G: ALA118G, ALA51G, ALA53G, ALA62F, ALA64F, ALA77F, ARG45F, ARG45G, ASN16G, ASN66F, ASP34G, CYS104F, CYS21G, GLN114G, GLN15G, GLN41F, GLN84F, GLN84G, GLU22G, GLU39F, GLU39G, GLU61F, GLU63F, GLU68F, GLU93F, GLY113G, GLY20G, GLY50G, GLY52G, GLY69F, GLY90F, GLY90G, GLY91F, GLY91G, HIS110G, HIS115G, HIS40F, HIS40G, HIS58F, ILE111G, ILE59F, ILE72F, ILE94F, LEU100F, LEU116G, LEU18G, LEU42F, LEU44F, LEU44G, LEU49G, LEU57F, LEU76F, LEU79F, LEU79G, LEU89F, LEU89G, LYS103F, LYS32G, LYS73F, LYS80F, LYS80G, MET65F, MET81G, PHE19G, PHE31G, PHE92F, PRO108G, PRO71F, PRO85F, PRO85G, PRO96F, PRO97F, SER112G, SER43F, SER43G, SER48G, SER70F, SER82F, SER82G, SER88F, SER88G, THR46G, THR75F, THR78F, THR86F, THR86G, THR95F, TYR17G, TYR29G, TYR67F, VAL109G, VAL117G, VAL33G, VAL47F, VAL47G, VAL60F, VAL74F, VAL83F, VAL83G, VAL87F, VAL87G, VAL98F, VAL99F
• F-H: GLN84F, GLN84H, VAL83F, VAL83H
• F-I: GLN84F, GLN84I, VAL83F, VAL83I
• F-J: ALA118F, ALA51F, ALA53F, ALA62J, ALA64J, ALA77J, ARG45F, ARG45J, ASN16F, ASN66J, ASP34F, ASP55F, CYS104J, CYS21F, GLN114F, GLN15F, GLN41J, GLN84F, GLN84J, GLU22F, GLU39J, GLU61J, GLU63J, GLU68J, GLU93J, GLY113F, GLY20F, GLY50F, GLY52F, GLY69J, GLY90F, GLY90J, GLY91F, GLY91J, HIS110F, HIS115F, HIS40F, HIS40J, HIS58J, ILE111F, ILE59J, ILE72J, ILE94J, LEU100J, LEU116F, LEU18F, LEU42J, LEU44F, LEU44J, LEU49F, LEU57J, LEU76J, LEU79F, LEU79J, LEU89F, LEU89J, LYS103J, LYS32F, LYS73J, LYS80F, LYS80J, MET65J, MET81F, PHE19F, PHE31F, PHE92J, PRO108F, PRO71J, PRO85F, PRO85J, PRO96J, PRO97J, SER112F, SER43F, SER43J, SER48F, SER70J, SER82F, SER82J, SER88F, SER88J, THR46F, THR75J, THR78J, THR86F, THR86J, THR95J, TYR17F, TYR29F, TYR67J, VAL109F, VAL117F, VAL33F, VAL47F, VAL47J, VAL60J, VAL74J, VAL83F, VAL83J, VAL87F, VAL87J, VAL98J, VAL99J
• G-H: ALA118H, ALA51H, ALA53H, ALA62G, ALA64G, ALA77G, ARG45G, ARG45H, ASN16H, ASN66G, ASP34H, CYS104G, CYS21H, GLN114H, GLN15H, GLN41G, GLN84G, GLN84H, GLU22H, GLU39G, GLU39H, GLU61G, GLU63G, GLU68G, GLU93G, GLY113H, GLY20H, GLY50H, GLY52H, GLY69G, GLY90G, GLY90H, GLY91G, GLY91H, HIS110H, HIS115H, HIS40G, HIS40H, HIS58G, ILE111H, ILE59G, ILE72G, ILE94G, LEU100G, LEU116H, LEU18H, LEU42G, LEU44G, LEU44H, LEU49H, LEU57G, LEU76G, LEU79G, LEU79H, LEU89G, LEU89H, LYS103G, LYS32H, LYS73G, LYS80G, LYS80H, MET65G, MET81H, PHE19H, PHE31H, PHE92G, PRO108H, PRO71G, PRO85G, PRO85H, PRO96G, PRO97G, SER112H, SER43G, SER43H, SER48H, SER70G, SER82G, SER82H, SER88G, SER88H, THR46H, THR75G, THR78G, THR86G, THR86H, THR95G, TYR17H, TYR29H, TYR67G, VAL109H, VAL117H, VAL33H, VAL47G, VAL47H, VAL60G, VAL74G, VAL83G, VAL83H, VAL87G, VAL87H, VAL98G, VAL99G
• G-I: GLN84G, GLN84I, VAL83G, VAL83I
• G-J: GLN84G, GLN84J, VAL83G, VAL83J
• H-I: ALA118I, ALA51I, ALA53I, ALA62H, ALA64H, ALA77H, ARG45H, ARG45I, ASN16I, ASN66H, ASP34I, CYS104H, CYS21I, GLN114I, GLN15I, GLN41H, GLN84H, GLN84I, GLU22I, GLU61H, GLU63H, GLU68H, GLU93H, GLY113I, GLY20I, GLY50I, GLY52I, GLY69H, GLY90H, GLY90I, GLY91H, GLY91I, HIS110I, HIS115I, HIS40H, HIS40I, HIS58H, ILE111I, ILE59H, ILE72H, ILE94H, LEU100H, LEU116I, LEU18I, LEU42H, LEU44H, LEU44I, LEU49I, LEU57H, LEU76H, LEU79H, LEU79I, LEU89H, LEU89I, LYS103H, LYS32I, LYS73H, LYS80H, LYS80I, MET65H, MET81I, PHE19I, PHE31I, PHE92H, PRO108I, PRO71H, PRO85H, PRO85I, PRO96H, PRO97H, SER112I, SER43H, SER43I, SER48I, SER70H, SER82H, SER82I, SER88H, SER88I, THR46H, THR46I, THR75H, THR78H, THR86H, THR86I, THR95H, TYR17I, TYR29I, TYR67H, VAL109I, VAL117I, VAL33I, VAL47H, VAL47I, VAL60H, VAL74H, VAL83H, VAL83I, VAL87H, VAL87I, VAL98H, VAL99H
• H-J: GLN84H, GLN84J, VAL83H, VAL83J
• I-J: ALA118J, ALA51J, ALA53J, ALA62I, ALA64I, ALA77I, ARG45I, ARG45J, ASN16J, ASN66I, ASP34J, CYS104I, CYS21J, GLN114J, GLN15J, GLN41I, GLN84I, GLN84J, GLU22J, GLU39I, GLU39J, GLU61I, GLU63I, GLU68I, GLU93I, GLY105I, GLY113J, GLY20J, GLY50J, GLY52J, GLY69I, GLY90I, GLY90J, GLY91I, GLY91J, HIS110J, HIS115J, HIS40I, HIS40J, HIS58I, ILE111J, ILE59I, ILE72I, ILE94I, LEU100I, LEU116I, LEU116J, LEU18J, LEU42I, LEU44I, LEU44J, LEU49J, LEU57I, LEU76I, LEU79I, LEU79J, LEU89I, LEU89J, LYS103I, LYS32J, LYS73I, LYS80I, LYS80J, MET65I, MET81I, MET81J, PHE19J, PHE31J, PHE92I, PRO108J, PRO71I, PRO85I, PRO85J, PRO96I, PRO97I, SER112J, SER43I, SER43J, SER48J, SER70I, SER82I, SER82J, SER88I, SER88J, THR46J, THR75I, THR78I, THR86I, THR86J, THR95I, TYR17J, TYR29J, TYR67I, VAL109J, VAL117J, VAL33J, VAL47I, VAL47J, VAL60I, VAL74I, VAL83I, VAL83J, VAL87I, VAL87J, VAL98I, VAL99I