2OX4

crystal structure of putative dehydratase from zymomonas mobilis zm4

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: F-H
  • Int. Res.: 183
  • Norm. En. per Res.: -4.243
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-106.2852	-75.4758	-586.959	-768.72	183	17	18	21242	4	34	44
A-C	-41.3665	25.2675	-152.292	-168.391	88	4	1	7127	0	40	42
A-F	-36.3627	20.3948	-132.996	-148.9639	86	5	1	6677	0	40	41
A-H	-71.1881	-49.792	-285.025	-406.0051	119	17	4	13162	10	61	64
B-C	-62.3452	-47.1236	-278.071	-387.5398	118	17	4	13047	8	59	64
B-G	-54.0043	13.2963	-150.154	-190.862	87	5	1	7220	1	39	40
B-H	-59.5555	11.2053	-149.659	-198.0092	87	6	1	7286	1	40	41
C-D	-47.0191	26.835	-147.101	-167.2852	87	6	1	6974	0	38	38
C-G	-103.8207	-73.2955	-589.606	-766.7222	187	17	18	21165	4	38	48
D-E	-93.6409	-72.9364	-589.369	-755.9463	183	17	18	21349	4	38	50
D-F	-51.1023	10.5432	-154.599	-195.1581	89	3	1	7255	2	39	41
D-G	-71.0591	-48.7362	-261.868	-381.6633	115	12	4	12317	9	59	64
E-F	-76.5531	-51.3475	-308.735	-436.6355	123	24	4	13948	9	61	64
E-G	-50.3043	30.1231	-153.383	-173.5641	87	5	1	7277	0	40	43
E-H	-53.2147	13.5252	-156.469	-196.1585	89	6	1	7422	2	40	41
F-H	-103.7552	-72.3146	-600.391	-776.4608	183	18	18	21766	6	35	44

Interface residues

• A-B: ALA317A, ALA317B, ALA41A, ALA41B, ALA48A, ALA48B, ALA49A, ALA49B, ALA50A, ALA50B, ALA57A, ALA57B, ALA58A, ALA58B, ARG176A, ARG176B, ARG20A, ARG20B, ARG248A, ARG248B, ARG266A, ARG266B, ARG270A, ARG270B, ASN214A, ASN214B, ASN242A, ASN242B, ASN246A, ASN246B, ASP219A, ASP219B, ASP288A, ASP288B, ASP386A, ASP386B, ASP55A, ASP55B, GLN130A, GLN130B, GLN83A, GLN83B, GLU177A, GLU177B, GLU182A, GLU182B, GLU213A, GLU213B, GLU239A, GLU239B, GLU240A, GLU240B, GLU265A, GLU265B, GLU278A, GLU278B, GLU73A, GLU73B, GLY178A, GLY178B, GLY216A, GLY216B, GLY264A, GLY264B, GLY272A, GLY272B, GLY39A, GLY39B, GLY43A, GLY43B, GLY45A, GLY45B, GLY46A, GLY46B, GLY51A, GLY51B, GLY82A, GLY82B, GLY84A, GLY84B, GLY85A, GLY85B, GLY86A, GLY86B, GLY92A, GLY92B, HIS10A, HIS10B, HIS12B, HIS215A, HIS215B, HIS217A, HIS217B, HIS315A, HIS315B, ILE22A, ILE22B, ILE241A, ILE241B, ILE267A, ILE267B, ILE390A, ILE40A, ILE40B, ILE52A, ILE52B, ILE89A, ILE89B, LEU181A, LEU181B, LEU245A, LEU245B, LEU249A, LEU249B, LEU274A, LEU274B, LEU53A, LEU53B, LEU59A, LEU59B, LEU60A, LEU60B, LEU75A, LEU75B, LYS344A, LYS54A, LYS54B, LYS74A, LYS74B, LYS77A, LYS77B, LYS78A, LYS78B, PHE180A, PHE180B, PHE76A, PHE76B, PHE80A, PHE80B, PHE90A, PHE90B, PRO244A, PRO244B, PRO247A, PRO247B, PRO275A, PRO275B, SER269A, SER269B, SER47A, SER47B, SER91A, SER91B, THR218A, THR218B, THR243A, THR243B, THR291A, THR291B, THR79A, THR79B, THR87A, THR87B, TRP271A, TRP271B, TRP72A, TRP72B, TRP81A, TRP81B, TYR268A, TYR268B, TYR42A, TYR42B, TYR56A, TYR56B, VAL179A, VAL179B, VAL388A, VAL388B, VAL44A, VAL44B, VAL88A, VAL88B
• A-C: ALA223A, ALA229A, ALA253A, ALA253C, ALA262C, ALA305C, ARG121C, ARG125C, ARG201C, ARG248A, ARG280C, ASN234C, ASN242A, ASN246A, ASN335C, ASP161C, ASP207C, ASP209C, ASP219A, ASP258C, ASP279C, ASP283C, CYS337C, GLN225A, GLU182A, GLU188A, GLU231C, GLU232C, GLU252A, GLU278C, GLU309C, GLY183A, GLY205C, GLY216A, HIS306C, ILE190A, ILE211C, ILE224A, ILE235C, ILE241A, ILE257C, ILE259C, ILE282C, ILE307C, ILE338C, LEU185A, LEU220A, LEU245A, LEU249A, LEU250A, LEU261C, LEU274C, LEU277C, LYS191A, LYS228A, LYS251A, LYS251C, LYS254C, LYS255A, LYS255C, LYS256A, LYS256C, MET304C, PHE180A, PHE236C, PHE237C, PHE276C, PHE308C, PHE336C, PRO184A, PRO186A, PRO206C, PRO244A, PRO260C, PRO275C, PRO334C, SER187A, SER222A, SER281C, THR189A, THR218A, THR243A, THR311C, VAL208C, VAL221A, VAL284C, VAL310C, VAL312C
• A-F: ALA223F, ALA229F, ALA253A, ALA253F, ALA262A, ALA305A, ARG121A, ARG125A, ARG201A, ARG248F, ARG280A, ASN234A, ASN242F, ASN246F, ASN335A, ASP161A, ASP207A, ASP209A, ASP219F, ASP258A, ASP279A, ASP283A, CYS337A, GLN225F, GLU182F, GLU188F, GLU231A, GLU232A, GLU252A, GLU252F, GLU278A, GLU309A, GLY183F, GLY205A, GLY216F, HIS306A, ILE190F, ILE211A, ILE224F, ILE235A, ILE241F, ILE257A, ILE259A, ILE282A, ILE307A, ILE338A, LEU185F, LEU220F, LEU245F, LEU249F, LEU250F, LEU261A, LEU277A, LYS191F, LYS228F, LYS251A, LYS251F, LYS254A, LYS255A, LYS255F, LYS256A, LYS256F, MET304A, PHE180F, PHE236A, PHE237A, PHE308A, PHE336A, PRO184F, PRO186F, PRO206A, PRO244F, PRO260A, PRO334A, SER187F, SER222F, SER281A, THR189F, THR218F, THR243F, THR311A, VAL208A, VAL221F, VAL284A, VAL310A, VAL312A
• A-H: ALA107A, ALA107H, ALA302A, ALA302H, ALA305A, ALA305H, ALA332A, ALA332H, ALA70A, ALA70H, ARG121A, ARG121H, ARG270A, ARG270H, ASN109A, ASN109H, ASN120A, ASN120H, ASN335A, ASN335H, ASN67A, ASN67H, ASP303A, ASP303H, ASP64A, ASP64H, GLN83A, GLN83H, GLU122A, GLU122H, GLU278A, GLU278H, GLU297A, GLU297H, GLU309A, GLU309H, GLU69A, GLU69H, GLU73A, GLU73H, GLY105A, GLY105H, GLY117A, GLY117H, GLY118A, GLY118H, GLY272A, HIS306A, HIS306H, ILE301A, ILE301H, ILE307A, ILE307H, ILE331A, ILE331H, ILE333A, ILE333H, ILE71A, ILE71H, LEU108A, LEU108H, LEU110A, LEU110H, LEU115A, LEU115H, LEU116A, LEU116H, LEU1A, LEU1H, LEU274A, LEU274H, LEU277A, LEU277H, LYS104A, LYS104H, LYS114A, LYS114H, LYS119A, LYS119H, LYS299A, LYS299H, LYS300A, LYS300H, LYS74A, LYS74H, LYS77A, LYS77H, MET304A, MET304H, PHE273A, PHE308A, PHE308H, PHE66A, PHE66H, PHE76A, PHE76H, PRO111A, PRO111H, PRO275A, PRO334A, PRO334H, PRO65A, PRO65H, SER0A, SER0H, SER269A, SER269H, THR296A, THR296H, THR68A, THR68H, TRP101A, TRP101H, TRP271A, TRP271H, TRP72A, TRP72H, TYR113A, TYR113H
• B-C: ALA107B, ALA107C, ALA302B, ALA302C, ALA305B, ALA305C, ALA332B, ALA332C, ALA70B, ALA70C, ARG121B, ARG121C, ARG270B, ARG270C, ASN109B, ASN109C, ASN120B, ASN120C, ASN335B, ASN335C, ASN67B, ASN67C, ASP303B, ASP303C, ASP64B, ASP64C, GLN83B, GLN83C, GLU122B, GLU122C, GLU278B, GLU278C, GLU297B, GLU297C, GLU309B, GLU309C, GLU69B, GLU69C, GLU73B, GLU73C, GLY105B, GLY117B, GLY117C, GLY118B, GLY118C, GLY272C, HIS306B, HIS306C, ILE301B, ILE301C, ILE307B, ILE307C, ILE331B, ILE331C, ILE333B, ILE333C, ILE71B, ILE71C, LEU108B, LEU108C, LEU110B, LEU110C, LEU115B, LEU115C, LEU116B, LEU116C, LEU1B, LEU1C, LEU274B, LEU274C, LEU277B, LEU277C, LYS104B, LYS104C, LYS114B, LYS114C, LYS119B, LYS119C, LYS299B, LYS299C, LYS300B, LYS300C, LYS74B, LYS74C, LYS77B, LYS77C, MET304B, MET304C, PHE273C, PHE308B, PHE308C, PHE66B, PHE66C, PHE76B, PHE76C, PRO111B, PRO275C, PRO334B, PRO334C, PRO65B, PRO65C, SER0B, SER0C, SER269B, SER269C, THR296B, THR296C, THR311C, THR68B, THR68C, TRP101B, TRP101C, TRP271B, TRP271C, TRP72B, TRP72C, TYR113B, TYR113C
• B-G: ALA223G, ALA229G, ALA253B, ALA253G, ALA262B, ALA305B, ARG121B, ARG125B, ARG201B, ARG248G, ARG280B, ASN234B, ASN242G, ASN246G, ASN335B, ASP161B, ASP207B, ASP209B, ASP219G, ASP258B, ASP279B, ASP283B, CYS337B, GLN225G, GLU182G, GLU188G, GLU231B, GLU252G, GLU278B, GLU309B, GLY183G, GLY205B, GLY216G, HIS306B, ILE190G, ILE211B, ILE224G, ILE235B, ILE241G, ILE257B, ILE259B, ILE282B, ILE307B, ILE338B, LEU185G, LEU220G, LEU245G, LEU249G, LEU250G, LEU261B, LEU274B, LEU277B, LYS191G, LYS228G, LYS251B, LYS251G, LYS254B, LYS255B, LYS255G, LYS256B, LYS256G, MET304B, PHE180G, PHE236B, PHE237B, PHE276B, PHE308B, PHE336B, PRO184G, PRO186G, PRO206B, PRO244G, PRO260B, PRO275B, PRO334B, SER187G, SER222G, SER281B, THR189G, THR218G, THR243G, THR311B, VAL208B, VAL221G, VAL284B, VAL310B, VAL312B
• B-H: ALA223B, ALA229B, ALA253B, ALA253H, ALA262H, ALA305H, ARG121H, ARG125H, ARG201H, ARG248B, ARG280H, ASN234H, ASN242B, ASN246B, ASN335H, ASP161H, ASP207H, ASP209H, ASP219B, ASP258H, ASP279H, ASP283H, CYS337H, GLN225B, GLU182B, GLU188B, GLU231H, GLU252B, GLU278H, GLU309H, GLY183B, GLY205H, GLY216B, HIS306H, ILE190B, ILE211H, ILE224B, ILE235H, ILE241B, ILE257H, ILE259H, ILE282H, ILE307H, ILE338H, LEU185B, LEU220B, LEU245B, LEU249B, LEU250B, LEU261H, LEU274H, LEU277H, LYS191B, LYS228B, LYS251B, LYS251H, LYS254H, LYS255B, LYS255H, LYS256B, LYS256H, MET304H, PHE180B, PHE236H, PHE237H, PHE276H, PHE308H, PHE336H, PRO184B, PRO186B, PRO206H, PRO244B, PRO260H, PRO275H, PRO334H, SER187B, SER222B, SER281H, THR189B, THR218B, THR243B, THR311H, VAL208H, VAL221B, VAL284H, VAL310H, VAL312H
• C-D: ALA223C, ALA229C, ALA253C, ALA253D, ALA262D, ALA305D, ARG121D, ARG125D, ARG201D, ARG248C, ARG280D, ASN234D, ASN242C, ASN246C, ASN335D, ASP161D, ASP207D, ASP209D, ASP219C, ASP258D, ASP279D, ASP283D, CYS337D, GLN225C, GLU182C, GLU188C, GLU231D, GLU252C, GLU278D, GLU309D, GLY183C, GLY205D, GLY216C, HIS306D, ILE190C, ILE211D, ILE224C, ILE235D, ILE241C, ILE257D, ILE259D, ILE282D, ILE307D, ILE338D, LEU185C, LEU220C, LEU245C, LEU249C, LEU250C, LEU261D, LEU274D, LEU277D, LYS191C, LYS228C, LYS251C, LYS251D, LYS254D, LYS255C, LYS255D, LYS256C, LYS256D, MET304D, PHE180C, PHE236D, PHE237D, PHE276D, PHE308D, PHE336D, PRO184C, PRO186C, PRO206D, PRO244C, PRO260D, PRO275D, PRO334D, SER187C, SER222C, SER281D, THR189C, THR218C, THR243C, THR311D, VAL208D, VAL221C, VAL284D, VAL310D, VAL312D
• C-G: ALA317C, ALA317G, ALA41C, ALA41G, ALA48C, ALA48G, ALA49C, ALA49G, ALA50C, ALA50G, ALA57C, ALA57G, ALA58C, ALA58G, ARG176C, ARG176G, ARG20C, ARG20G, ARG248C, ARG248G, ARG266C, ARG266G, ARG270C, ARG270G, ASN214C, ASN214G, ASN242C, ASN242G, ASN246C, ASN246G, ASP219C, ASP219G, ASP288C, ASP288G, ASP386C, ASP386G, ASP55C, ASP55G, GLN130C, GLN130G, GLN19G, GLN83C, GLN83G, GLU177C, GLU177G, GLU182C, GLU182G, GLU213C, GLU213G, GLU239C, GLU239G, GLU240C, GLU240G, GLU265C, GLU265G, GLU278C, GLU278G, GLU73C, GLU73G, GLY178C, GLY178G, GLY216C, GLY216G, GLY264C, GLY264G, GLY272C, GLY272G, GLY39C, GLY39G, GLY43C, GLY43G, GLY45C, GLY45G, GLY46C, GLY46G, GLY51C, GLY51G, GLY82C, GLY82G, GLY84C, GLY84G, GLY85C, GLY85G, GLY86C, GLY86G, GLY92C, GLY92G, HIS10C, HIS10G, HIS12C, HIS12G, HIS215C, HIS215G, HIS217C, HIS217G, HIS315C, HIS315G, HIS396C, HIS398C, ILE22C, ILE22G, ILE241C, ILE241G, ILE267C, ILE267G, ILE40C, ILE40G, ILE52C, ILE52G, ILE89C, ILE89G, ILE93C, LEU181C, LEU181G, LEU245C, LEU245G, LEU249C, LEU249G, LEU274C, LEU274G, LEU53C, LEU53G, LEU59C, LEU59G, LEU60C, LEU60G, LEU75C, LEU75G, LYS344C, LYS54C, LYS54G, LYS74C, LYS74G, LYS77C, LYS77G, LYS78C, LYS78G, PHE180C, PHE180G, PHE76C, PHE76G, PHE80C, PHE80G, PHE90C, PHE90G, PRO244C, PRO244G, PRO247C, PRO247G, PRO275C, PRO275G, SER269C, SER269G, SER47C, SER47G, SER91C, SER91G, THR218C, THR218G, THR243C, THR243G, THR291C, THR291G, THR79C, THR79G, THR87C, THR87G, TRP271C, TRP271G, TRP72C, TRP72G, TRP81C, TRP81G, TYR268C, TYR268G, TYR42C, TYR42G, TYR56C, TYR56G, VAL179C, VAL179G, VAL388C, VAL388G, VAL44C, VAL44G, VAL88C, VAL88G
• D-E: ALA317D, ALA317E, ALA41D, ALA41E, ALA48D, ALA48E, ALA49D, ALA49E, ALA50D, ALA50E, ALA57D, ALA57E, ALA58D, ALA58E, ARG176D, ARG176E, ARG20D, ARG20E, ARG248D, ARG248E, ARG266D, ARG266E, ARG270D, ARG270E, ASN214D, ASN214E, ASN242D, ASN242E, ASN246D, ASN246E, ASP219D, ASP219E, ASP288D, ASP288E, ASP386D, ASP386E, ASP55D, ASP55E, GLN130D, GLN130E, GLN83D, GLN83E, GLU177D, GLU177E, GLU182D, GLU182E, GLU213D, GLU213E, GLU239D, GLU239E, GLU240D, GLU240E, GLU265D, GLU265E, GLU278D, GLU278E, GLU73D, GLU73E, GLY178D, GLY178E, GLY216D, GLY216E, GLY264D, GLY264E, GLY272D, GLY272E, GLY39D, GLY39E, GLY43D, GLY43E, GLY45D, GLY45E, GLY46D, GLY46E, GLY51D, GLY51E, GLY82D, GLY82E, GLY84D, GLY84E, GLY85D, GLY85E, GLY86D, GLY86E, GLY92D, GLY92E, HIS10D, HIS10E, HIS215D, HIS215E, HIS217D, HIS217E, HIS315D, HIS315E, HIS396D, HIS398D, ILE22D, ILE22E, ILE241D, ILE241E, ILE267D, ILE267E, ILE40D, ILE40E, ILE52D, ILE52E, ILE89D, ILE89E, LEU181D, LEU181E, LEU245D, LEU245E, LEU249D, LEU249E, LEU274D, LEU274E, LEU53D, LEU53E, LEU59D, LEU59E, LEU60D, LEU60E, LEU75D, LEU75E, LYS344D, LYS54D, LYS54E, LYS74D, LYS74E, LYS77D, LYS77E, LYS78D, LYS78E, PHE180D, PHE180E, PHE76D, PHE76E, PHE80D, PHE80E, PHE90D, PHE90E, PRO244D, PRO244E, PRO247D, PRO247E, PRO275D, PRO275E, SER269D, SER269E, SER47D, SER47E, SER91D, SER91E, THR218D, THR218E, THR243D, THR243E, THR291D, THR291E, THR79D, THR79E, THR87D, THR87E, TRP271D, TRP271E, TRP72D, TRP72E, TRP81D, TRP81E, TYR268D, TYR268E, TYR42D, TYR42E, TYR56D, TYR56E, VAL179D, VAL179E, VAL388D, VAL388E, VAL44D, VAL44E, VAL88D, VAL88E
• D-F: ALA223D, ALA229D, ALA253D, ALA253F, ALA262F, ALA305F, ARG121F, ARG125F, ARG201F, ARG248D, ARG280F, ASN120F, ASN234F, ASN242D, ASN246D, ASN335F, ASP161F, ASP207F, ASP209F, ASP219D, ASP258F, ASP279F, ASP283F, CYS337F, GLN225D, GLU182D, GLU188D, GLU231F, GLU252D, GLU252F, GLU278F, GLU309F, GLY183D, GLY205F, GLY216D, HIS306F, ILE190D, ILE211F, ILE224D, ILE235F, ILE241D, ILE257F, ILE259F, ILE282F, ILE307F, ILE338F, LEU185D, LEU220D, LEU245D, LEU249D, LEU250D, LEU261F, LEU274F, LEU277F, LYS191D, LYS228D, LYS251D, LYS251F, LYS254F, LYS255D, LYS255F, LYS256D, LYS256F, MET304F, PHE180D, PHE236F, PHE237F, PHE276F, PHE308F, PHE336F, PRO184D, PRO186D, PRO206F, PRO244D, PRO260F, PRO275F, PRO334F, SER187D, SER222D, SER281F, THR189D, THR218D, THR243D, THR311F, VAL208F, VAL221D, VAL284F, VAL310F, VAL312F
• D-G: ALA107D, ALA107G, ALA302D, ALA302G, ALA305D, ALA305G, ALA332D, ALA332G, ALA70D, ALA70G, ARG121D, ARG121G, ARG270D, ARG270G, ASN109D, ASN109G, ASN120D, ASN120G, ASN335D, ASN335G, ASN67D, ASN67G, ASP303D, ASP303G, ASP64D, ASP64G, GLN83D, GLN83G, GLU122D, GLU122G, GLU278D, GLU278G, GLU297D, GLU297G, GLU309D, GLU309G, GLU69D, GLU69G, GLU73D, GLU73G, GLY105G, GLY117D, GLY117G, GLY118D, GLY118G, GLY272G, HIS306D, HIS306G, ILE301D, ILE301G, ILE307D, ILE307G, ILE331D, ILE331G, ILE333D, ILE333G, ILE71D, ILE71G, LEU108D, LEU108G, LEU110D, LEU110G, LEU115D, LEU115G, LEU116D, LEU116G, LEU1D, LEU1G, LEU274D, LEU274G, LEU277D, LEU277G, LYS104D, LYS104G, LYS114D, LYS114G, LYS119D, LYS119G, LYS299D, LYS299G, LYS300D, LYS300G, LYS74D, LYS74G, LYS77D, LYS77G, MET304D, MET304G, PHE308D, PHE308G, PHE66D, PHE66G, PHE76D, PHE76G, PRO111D, PRO111G, PRO334D, PRO334G, PRO65D, PRO65G, SER0D, SER0G, SER269G, THR296D, THR296G, THR68D, THR68G, TRP101D, TRP101G, TRP271D, TRP271G, TRP72D, TRP72G, TYR113D, TYR113G
• E-F: ALA107E, ALA107F, ALA302E, ALA302F, ALA305E, ALA305F, ALA332E, ALA332F, ALA70E, ALA70F, ARG121E, ARG121F, ARG270E, ARG270F, ASN109E, ASN109F, ASN120E, ASN120F, ASN335E, ASN335F, ASN67E, ASN67F, ASP279F, ASP303E, ASP303F, ASP64E, ASP64F, GLN83E, GLN83F, GLU122E, GLU122F, GLU278E, GLU278F, GLU297E, GLU297F, GLU309E, GLU309F, GLU69E, GLU69F, GLU73E, GLU73F, GLY105E, GLY105F, GLY117E, GLY117F, GLY118E, GLY118F, GLY272E, GLY272F, HIS306E, HIS306F, ILE301E, ILE301F, ILE307E, ILE307F, ILE331E, ILE331F, ILE333E, ILE333F, ILE71E, ILE71F, LEU108E, LEU108F, LEU110E, LEU110F, LEU115E, LEU115F, LEU116E, LEU116F, LEU1E, LEU1F, LEU274E, LEU274F, LEU277E, LEU277F, LYS104E, LYS104F, LYS114E, LYS114F, LYS119E, LYS119F, LYS299E, LYS299F, LYS300E, LYS300F, LYS74E, LYS74F, LYS77E, LYS77F, MET304E, MET304F, PHE273E, PHE273F, PHE308E, PHE308F, PHE66E, PHE66F, PHE76E, PHE76F, PRO111E, PRO111F, PRO275E, PRO275F, PRO334E, PRO334F, PRO65E, PRO65F, SER0E, SER0F, SER269E, SER269F, THR296E, THR296F, THR68E, THR68F, TRP101E, TRP101F, TRP271E, TRP271F, TRP72E, TRP72F, TYR113E, TYR113F
• E-G: ALA223E, ALA229E, ALA253E, ALA253G, ALA262G, ALA305G, ARG121G, ARG125G, ARG201G, ARG248E, ARG280G, ASN234G, ASN242E, ASN246E, ASN335G, ASP161G, ASP207G, ASP209G, ASP219E, ASP258G, ASP279G, ASP283G, CYS337G, GLN225E, GLU182E, GLU188E, GLU231G, GLU252E, GLU278G, GLU309G, GLY183E, GLY205G, GLY216E, HIS306G, ILE190E, ILE211G, ILE224E, ILE235G, ILE241E, ILE257G, ILE259G, ILE282G, ILE307G, ILE338G, LEU185E, LEU220E, LEU245E, LEU249E, LEU250E, LEU261G, LEU274G, LEU277G, LYS191E, LYS228E, LYS251E, LYS251G, LYS254G, LYS255E, LYS255G, LYS256E, LYS256G, MET304G, PHE180E, PHE236G, PHE237G, PHE276G, PHE308G, PHE336G, PRO184E, PRO186E, PRO206G, PRO244E, PRO260G, PRO275G, PRO334G, SER187E, SER222E, SER281G, THR189E, THR218E, THR243E, THR311G, VAL208G, VAL221E, VAL284G, VAL310G, VAL312G
• E-H: ALA223H, ALA229H, ALA253E, ALA253H, ALA262E, ALA305E, ARG121E, ARG125E, ARG201E, ARG248H, ARG280E, ASN120E, ASN234E, ASN242H, ASN246H, ASN335E, ASP161E, ASP207E, ASP209E, ASP219H, ASP258E, ASP279E, ASP283E, CYS337E, GLN225H, GLU182H, GLU188H, GLU231E, GLU232E, GLU252H, GLU278E, GLU309E, GLY183H, GLY205E, GLY216H, HIS306E, ILE190H, ILE211E, ILE224H, ILE235E, ILE241H, ILE257E, ILE259E, ILE282E, ILE307E, ILE338E, LEU185H, LEU220H, LEU245H, LEU249H, LEU250H, LEU261E, LEU274E, LEU277E, LYS191H, LYS228H, LYS251E, LYS251H, LYS254E, LYS255E, LYS255H, LYS256E, LYS256H, MET304E, PHE180H, PHE236E, PHE237E, PHE276E, PHE308E, PHE336E, PRO184H, PRO186H, PRO206E, PRO244H, PRO260E, PRO275E, PRO334E, SER187H, SER222H, SER281E, THR189H, THR218H, THR243H, THR311E, VAL208E, VAL221H, VAL284E, VAL310E, VAL312E
• F-H: ALA317F, ALA317H, ALA41F, ALA41H, ALA48F, ALA48H, ALA49F, ALA49H, ALA50F, ALA50H, ALA57F, ALA57H, ALA58F, ALA58H, ARG176F, ARG176H, ARG20F, ARG20H, ARG248F, ARG248H, ARG266F, ARG266H, ARG270F, ARG270H, ASN214F, ASN214H, ASN242F, ASN242H, ASN246F, ASN246H, ASP219F, ASP219H, ASP279H, ASP288F, ASP288H, ASP386F, ASP386H, ASP55F, ASP55H, GLN130F, GLN130H, GLN83F, GLN83H, GLU177F, GLU177H, GLU182F, GLU182H, GLU213F, GLU213H, GLU239F, GLU239H, GLU240F, GLU240H, GLU265F, GLU265H, GLU278F, GLU278H, GLU73F, GLU73H, GLY178F, GLY178H, GLY216F, GLY216H, GLY264F, GLY264H, GLY272F, GLY272H, GLY39F, GLY39H, GLY43F, GLY43H, GLY45F, GLY45H, GLY46F, GLY46H, GLY51F, GLY51H, GLY82F, GLY82H, GLY84F, GLY84H, GLY85F, GLY85H, GLY86F, GLY86H, GLY92F, GLY92H, HIS10F, HIS10H, HIS12F, HIS12H, HIS215F, HIS215H, HIS217F, HIS217H, HIS315F, HIS315H, ILE241F, ILE241H, ILE267F, ILE267H, ILE40F, ILE40H, ILE52F, ILE52H, ILE89F, ILE89H, LEU181F, LEU181H, LEU245F, LEU245H, LEU249F, LEU249H, LEU274F, LEU274H, LEU53F, LEU53H, LEU59F, LEU59H, LEU60F, LEU60H, LEU75F, LEU75H, LYS344F, LYS344H, LYS54F, LYS54H, LYS74F, LYS74H, LYS77F, LYS77H, LYS78F, LYS78H, PHE180F, PHE180H, PHE76F, PHE76H, PHE80F, PHE80H, PHE90F, PHE90H, PRO244F, PRO244H, PRO247F, PRO247H, PRO275F, PRO275H, SER269F, SER269H, SER47F, SER47H, SER91F, SER91H, THR218F, THR218H, THR243F, THR243H, THR291F, THR291H, THR79F, THR79H, THR87F, THR87H, TRP271F, TRP271H, TRP72F, TRP72H, TRP81F, TRP81H, TYR268F, TYR268H, TYR42F, TYR42H, TYR56F, TYR56H, VAL179F, VAL179H, VAL388F, VAL388H, VAL44F, VAL44H, VAL88F, VAL88H