2ONM

human mitochondrial aldehyde dehydrogenase asian variant, aldh2*2, complexed with nad+

• Total interactions analyzed: 66
• Total true interactions: 23
• Strongest Interaction:
  • Chains: F-G
  • Int. Res.: 131
  • Norm. En. per Res.: -4.1936
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-176.8288	-25.2826	-672.023	-874.1344	260	43	15	29807	4	45	46
A-C	-46.3073	26.209	-232.485	-252.5833	120	5	0	9556	2	43	38
A-D	-155.0663	32.3274	-419.139	-541.8779	134	25	4	14977	3	46	55
A-F	0.0	0.0	-0.0283	-0.0283	4	0	0	5	0	2	7
B-C	-151.3949	29.6631	-399.229	-520.9609	132	20	4	14617	2	46	55
B-D	-41.0328	27.7627	-245.679	-258.9491	117	5	0	9855	2	44	40
C-D	-200.8656	-31.8196	-714.1	-946.7851	260	54	15	30472	4	46	50
D-F	0.0	21.8783	-11.069	10.8093	23	0	0	710	0	15	19
D-H	-9.0517	-3.7734	-39.2193	-52.0444	47	0	3	2381	0	16	12
E-F	-188.5866	-29.4945	-687.145	-905.2261	256	41	15	30081	4	46	47
E-G	-40.5216	24.3976	-238.378	-254.502	121	5	0	9578	2	43	40
E-H	-168.9564	33.0021	-422.196	-558.1503	135	28	4	15127	2	46	55
E-I	-12.5402	3.9383	-48.5874	-57.1892	52	15	1	3158	2	7	8
F-G	-166.1594	28.979	-412.179	-549.3594	131	29	4	15084	2	46	55
F-H	-36.5178	23.5626	-231.556	-244.5111	121	3	0	9573	2	42	40
G-H	-199.024	-41.1671	-694.884	-935.0751	259	54	15	30450	6	45	48
G-K	-13.6332	-8.5042	-13.2529	-35.3903	15	5	0	644	1	5	4
I-J	-181.5749	-30.102	-670.346	-882.0229	255	53	14	29588	4	44	47
I-K	-11.4107	27.4322	-215.633	-199.6115	119	3	0	9155	2	42	39
I-L	-151.1221	31.5398	-420.091	-539.6733	135	35	4	15206	2	45	56
J-K	-167.7493	31.6405	-425.837	-561.9458	134	25	4	15066	2	47	56
J-L	-30.4938	20.4688	-216.249	-226.274	120	3	0	9340	2	42	37
K-L	-203.6472	-36.2823	-707.41	-947.3395	260	45	15	30338	4	45	47

Interface residues

• A-B: ALA256A, ALA256B, ALA257A, ALA257B, ALA428A, ALA428B, ALA429A, ALA429B, ALA430A, ALA430B, ALA439A, ALA439B, ALA445A, ALA445B, ALA448A, ALA448B, ALA461A, ALA461B, ARG155A, ARG155B, ARG251A, ARG251B, ARG264A, ARG264B, ARG475A, ARG475B, ARG67A, ARG67B, ARG77A, ARG77B, ARG78A, ARG78B, ASN261A, ASN261B, ASN421A, ASN421B, ASN440A, ASN440B, ASN454A, ASN454B, ASP123A, ASP123B, ASP147A, ASP147B, ASP149A, ASP149B, ASP237B, ASP239A, ASP239B, ASP282A, ASP282B, ASP457A, ASP457B, CYS455A, CYS455B, GLN254A, GLN254B, GLN289A, GLN289B, GLN444A, GLN444B, GLN447A, GLN447B, GLN462A, GLN462B, GLN483A, GLN483B, GLN71A, GLN71B, GLU157A, GLU157B, GLU236A, GLU236B, GLU248A, GLU248B, GLU268B, GLU414B, GLU476B, GLU479A, GLU479B, GLY141A, GLY141B, GLY148A, GLY148B, GLY250A, GLY250B, GLY258A, GLY258B, GLY426A, GLY426B, GLY449A, GLY449B, GLY460A, GLY460B, GLY466A, GLY466B, GLY467A, GLY467B, GLY472A, GLY472B, GLY474A, GLY474B, GLY478A, GLY478B, GLY73A, GLY73B, HIS140A, HIS140B, HIS156A, HIS156B, ILE144A, ILE144B, ILE146A, ILE146B, ILE249A, ILE249B, ILE253A, ILE253B, LEU262A, LEU262B, LEU267A, LEU267B, LEU269A, LEU269B, LEU427A, LEU427B, LEU436A, LEU436B, LEU442A, LEU442B, LEU446A, LEU446B, LEU477A, LEU477B, LEU72A, LEU72B, LYS127A, LYS127B, LYS142A, LYS142B, LYS263A, LYS263B, LYS469A, LYS469B, LYS487A, LYS487B, LYS489A, LYS489B, LYS494A, LYS494B, LYS498A, LYS498B, MET124A, MET124B, MET470A, MET470B, PHE150A, PHE150B, PHE151A, PHE151B, PHE243A, PHE243B, PHE432A, PHE432B, PHE459A, PHE459B, PHE465A, PHE465B, PHE70A, PHE70B, PRO145A, PRO145B, PRO158A, PRO158B, PRO464A, PRO464B, SER152A, SER152B, SER246A, SER246B, SER259A, SER259B, SER260A, SER260B, SER443A, SER443B, SER463A, SER463B, SER471A, SER471B, SER473A, SER473B, THR143A, THR143B, THR154A, THR154B, THR247A, THR247B, THR424A, THR424B, THR433A, THR433B, THR450A, THR450B, THR486A, THR486B, THR490A, THR490B, THR492A, THR492B, TRP135A, TRP135B, TRP285A, TRP285B, TRP452A, TRP452B, TYR131A, TYR131B, TYR139A, TYR139B, TYR153A, TYR153B, TYR425A, TYR425B, TYR441A, TYR441B, TYR456A, TYR456B, TYR468A, TYR468B, TYR480A, TYR480B, VAL159A, VAL159B, VAL241A, VAL241B, VAL252A, VAL252B, VAL255A, VAL255B, VAL265A, VAL265B, VAL417A, VAL417B, VAL431A, VAL431B, VAL451A, VAL451B, VAL453A, VAL453B, VAL458A, VAL458B, VAL488A, VAL488B, VAL491A, VAL491B, VAL493A, VAL493B, VAL495A, VAL495B
• A-C: ALA133A, ALA133C, ALA136A, ALA136C, ALA184A, ALA184C, ALA439A, ALA439C, ALA445A, ALA445C, ALA461A, ALA461C, ALA81A, ALA81C, ALA92A, ALA92C, ARG130A, ARG130C, ARG86A, ARG86C, ASN440A, ASN440C, ASN499A, ASN499C, ASN89A, ASN89C, ASP137A, ASP137C, ASP149A, ASP149C, ASP435A, ASP435C, ASP437A, ASP437C, ASP80A, ASP80C, ASP93A, ASP93C, CYS128A, CYS128C, GLN444A, GLN444C, GLN462A, GLN462C, GLN497A, GLN497C, GLU479A, GLU479C, GLU96A, GLU96C, GLY134A, GLY134C, GLY141C, GLY478A, GLY478C, GLY85A, GLY85C, HIS140A, HIS140C, HIS83A, HIS83C, ILE413A, ILE413C, LEU126A, LEU126C, LEU129A, LEU129C, LEU436A, LEU436C, LEU442A, LEU442C, LEU482A, LEU482C, LYS127A, LYS127C, LYS138A, LYS138C, LYS142C, LYS438A, LYS438C, LYS494A, LYS494C, LYS498A, LYS498C, PHE150A, PHE150C, PHE151A, PHE151C, PRO464A, PRO464C, PRO496A, PRO496C, SER443A, SER443C, SER463A, SER463C, SER500A, SER500C, SER82A, SER82C, THR143A, THR143C, TRP135A, TRP135C, TYR131A, TYR131C, TYR132A, TYR132C, TYR139A, TYR139C, TYR153A, TYR153C, TYR441A, TYR441C, TYR480A, TYR480C, VAL493A, VAL493C, VAL495A, VAL495C
• A-D: ALA136A, ALA136D, ALA184A, ALA184D, ALA439A, ALA439D, ALA81A, ALA81D, ARG155A, ARG155D, ARG77A, ARG77D, ARG78A, ARG78D, ARG84A, ARG84D, ASN187A, ASN187D, ASN440A, ASN440D, ASN454A, ASN454D, ASN499A, ASN499D, ASP137A, ASP137D, ASP147A, ASP147D, ASP149A, ASP149D, ASP280A, ASP280D, ASP282A, ASP282D, ASP435A, ASP435D, ASP437A, ASP437D, ASP80A, ASP80D, GLN497A, GLN497D, GLN71A, GLN71D, GLU157A, GLU157D, GLY141A, GLY141D, GLY148A, GLY148D, GLY186A, GLY186D, GLY73A, GLY73D, HIS140A, HIS140D, HIS156A, HIS156D, HIS83A, HIS83D, ILE144A, ILE144D, ILE146A, ILE146D, LEU436A, LEU436D, LEU72A, LEU72D, LYS138A, LYS138D, LYS142A, LYS142D, LYS434A, LYS434D, LYS438A, LYS438D, LYS489A, LYS489D, LYS498A, LYS498D, MET79A, MET79D, PHE150A, PHE150D, PHE151A, PHE151D, PHE432A, PHE432D, PHE70A, PHE70D, PRO145A, PRO145D, PRO158A, PRO158D, PRO496A, PRO496D, PRO75D, SER152A, SER152D, SER500A, SER500D, SER74A, SER74D, SER82A, SER82D, THR143A, THR143D, THR154A, THR154D, THR185A, THR185D, THR433A, THR433D, THR490A, THR490D, TRP135A, TRP135D, TRP76A, TRP76D, TYR139A, TYR139D, TYR153A, TYR153D, VAL188A, VAL431A, VAL431D, VAL453A, VAL453D, VAL491A, VAL491D, VAL493A, VAL493D, VAL495A, VAL495D
• A-F: ARG377F, ASP313A, ASP316A, GLN14F
• B-C: ALA136B, ALA136C, ALA184C, ALA439B, ALA439C, ALA81B, ALA81C, ARG155B, ARG155C, ARG77B, ARG77C, ARG78B, ARG78C, ARG84B, ARG84C, ASN187B, ASN187C, ASN440B, ASN440C, ASN454B, ASN454C, ASN499B, ASN499C, ASP137B, ASP137C, ASP147B, ASP147C, ASP149B, ASP149C, ASP280B, ASP280C, ASP282B, ASP282C, ASP435B, ASP435C, ASP437B, ASP437C, ASP80B, ASP80C, GLN497B, GLN497C, GLN71B, GLN71C, GLU157B, GLU157C, GLY141B, GLY141C, GLY148B, GLY148C, GLY186B, GLY186C, GLY73B, GLY73C, HIS140B, HIS140C, HIS156B, HIS156C, HIS83B, HIS83C, ILE144B, ILE144C, ILE146B, ILE146C, LEU436B, LEU436C, LEU72B, LEU72C, LYS138B, LYS138C, LYS142B, LYS142C, LYS434B, LYS434C, LYS438B, LYS438C, LYS489B, LYS489C, LYS498B, LYS498C, MET79B, MET79C, PHE150B, PHE150C, PHE151B, PHE151C, PHE432B, PHE432C, PHE70B, PHE70C, PRO145B, PRO145C, PRO158B, PRO158C, PRO496B, PRO496C, SER152B, SER152C, SER500B, SER500C, SER74B, SER74C, SER82B, SER82C, THR143B, THR143C, THR154B, THR154C, THR185B, THR185C, THR433B, THR433C, THR490B, THR490C, TRP135B, TRP135C, TRP76B, TRP76C, TYR139B, TYR139C, TYR153B, TYR153C, VAL188C, VAL431B, VAL431C, VAL453B, VAL453C, VAL491B, VAL491C, VAL493B, VAL493C, VAL495B, VAL495C
• B-D: ALA133B, ALA133D, ALA136B, ALA136D, ALA184B, ALA184D, ALA439B, ALA439D, ALA445B, ALA445D, ALA461B, ALA461D, ALA81B, ALA81D, ALA92B, ALA92D, ARG130B, ARG130D, ARG86B, ARG86D, ASN440B, ASN440D, ASN499B, ASN499D, ASN89B, ASN89D, ASP137B, ASP137D, ASP149B, ASP149D, ASP435B, ASP435D, ASP437B, ASP437D, ASP80B, ASP80D, ASP93B, ASP93D, CYS128B, CYS128D, GLN444B, GLN444D, GLN462B, GLN462D, GLN497B, GLN497D, GLU479B, GLU479D, GLU96B, GLU96D, GLY134B, GLY134D, GLY478B, GLY478D, GLY85B, GLY85D, HIS140B, HIS140D, HIS83B, HIS83D, ILE413B, ILE413D, LEU126B, LEU126D, LEU129B, LEU129D, LEU436B, LEU436D, LEU442B, LEU442D, LEU482B, LEU482D, LYS127B, LYS127D, LYS138B, LYS138D, LYS438B, LYS438D, LYS494B, LYS494D, LYS498B, LYS498D, PHE150B, PHE150D, PHE151B, PHE151D, PRO464B, PRO464D, PRO496B, PRO496D, SER443D, SER463B, SER463D, SER500B, SER500D, SER82B, SER82D, THR143B, THR143D, TRP135B, TRP135D, TYR131B, TYR131D, TYR132B, TYR132D, TYR139B, TYR139D, TYR153B, TYR153D, TYR441B, TYR441D, TYR480B, TYR480D, VAL493B, VAL493D, VAL495B, VAL495D
• C-D: ALA256C, ALA256D, ALA257C, ALA257D, ALA428C, ALA428D, ALA429C, ALA429D, ALA430C, ALA430D, ALA439C, ALA439D, ALA445C, ALA445D, ALA448C, ALA448D, ALA461C, ALA461D, ARG155C, ARG155D, ARG251C, ARG251D, ARG264C, ARG264D, ARG475C, ARG475D, ARG67C, ARG67D, ARG77C, ARG77D, ARG78C, ARG78D, ASN261C, ASN261D, ASN421C, ASN421D, ASN440C, ASN440D, ASN454C, ASN454D, ASP123C, ASP123D, ASP147C, ASP147D, ASP149C, ASP149D, ASP239C, ASP239D, ASP282C, ASP282D, ASP457C, ASP457D, CYS455C, CYS455D, GLN254C, GLN254D, GLN289C, GLN289D, GLN444C, GLN444D, GLN447C, GLN447D, GLN462C, GLN462D, GLN483C, GLN483D, GLN71C, GLN71D, GLU157C, GLU157D, GLU236C, GLU236D, GLU248C, GLU248D, GLU476C, GLU476D, GLU479C, GLU479D, GLY141C, GLY141D, GLY148C, GLY148D, GLY250C, GLY250D, GLY258C, GLY258D, GLY418D, GLY426C, GLY426D, GLY449C, GLY449D, GLY460C, GLY460D, GLY466C, GLY466D, GLY467C, GLY467D, GLY472C, GLY472D, GLY474C, GLY474D, GLY478C, GLY478D, GLY73C, GLY73D, HIS140C, HIS140D, HIS156C, HIS156D, ILE144C, ILE144D, ILE146C, ILE146D, ILE249C, ILE249D, ILE253C, ILE253D, LEU262C, LEU262D, LEU267C, LEU267D, LEU269C, LEU269D, LEU427C, LEU427D, LEU436C, LEU436D, LEU442C, LEU442D, LEU446C, LEU446D, LEU477C, LEU477D, LEU72C, LEU72D, LYS127C, LYS127D, LYS142C, LYS142D, LYS263C, LYS263D, LYS469C, LYS469D, LYS487C, LYS487D, LYS489C, LYS489D, LYS494C, LYS494D, LYS498C, LYS498D, MET124C, MET470C, MET470D, PHE150C, PHE150D, PHE151C, PHE151D, PHE243C, PHE243D, PHE432C, PHE432D, PHE459C, PHE459D, PHE465C, PHE465D, PHE70C, PHE70D, PRO145C, PRO145D, PRO158C, PRO158D, PRO464C, PRO464D, PRO496C, PRO496D, SER152C, SER152D, SER246C, SER246D, SER259C, SER259D, SER260C, SER260D, SER443C, SER443D, SER463C, SER463D, SER471C, SER471D, SER473C, SER473D, THR143C, THR143D, THR154C, THR154D, THR247C, THR247D, THR266C, THR266D, THR424C, THR424D, THR433C, THR433D, THR450C, THR450D, THR486C, THR486D, THR490C, THR490D, THR492C, THR492D, TRP135C, TRP135D, TRP285C, TRP285D, TRP452C, TRP452D, TYR131C, TYR131D, TYR139C, TYR139D, TYR153C, TYR153D, TYR425D, TYR441C, TYR441D, TYR456C, TYR456D, TYR468C, TYR468D, TYR480C, TYR480D, VAL159C, VAL159D, VAL241C, VAL252C, VAL252D, VAL255C, VAL255D, VAL265C, VAL265D, VAL417C, VAL417D, VAL431C, VAL431D, VAL451C, VAL451D, VAL453C, VAL453D, VAL458C, VAL458D, VAL488C, VAL488D, VAL491C, VAL491D, VAL493C, VAL493D, VAL495C, VAL495D
• D-F: ALA10F, ALA324D, ARG321D, ARG90F, ARG97F, ASN12F, ASP313D, ASP316D, ASP93F, ASP98F, GLU16F, GLU210F, GLU317D, GLU320D, GLU96F, LEU207F, LEU94F, LYS434D, MET283D, PHE318D, PRO9F, THR100F, TYR203F
• D-H: ALA10H, ALA365D, ALA374D, ALA375D, ARG90H, ARG97H, ARG99H, ASN12H, ASN358D, ASP376D, ASP388D, ASP98H, CYS369D, GLN13H, GLN14H, GLN362D, GLN382D, GLU16H, GLU210H, GLU363D, GLU96H, GLY364D, GLY370D, GLY371D, GLY372D, GLY387D, ILE373D, LEU354D, LEU367D, LEU368D, LEU94H, LYS327D, LYS361D, LYS366D, PHE18H, PRO11H, PRO15H, PRO9H, THR100H, THR359D, TYR101H, TYR114H, TYR118H, TYR203H, VAL17H, VAL323D, VAL8H
• E-F: ALA256E, ALA256F, ALA257E, ALA257F, ALA428E, ALA428F, ALA429E, ALA429F, ALA430E, ALA430F, ALA439E, ALA439F, ALA445E, ALA445F, ALA448E, ALA448F, ALA461E, ALA461F, ARG155E, ARG155F, ARG251E, ARG251F, ARG264E, ARG264F, ARG475E, ARG475F, ARG67E, ARG67F, ARG77E, ARG77F, ARG78E, ARG78F, ASN261E, ASN261F, ASN421E, ASN421F, ASN440E, ASN440F, ASN454E, ASN454F, ASP123E, ASP123F, ASP147E, ASP147F, ASP149E, ASP149F, ASP239E, ASP239F, ASP282E, ASP282F, ASP457E, ASP457F, CYS455E, CYS455F, GLN254E, GLN254F, GLN289E, GLN289F, GLN444E, GLN444F, GLN447E, GLN447F, GLN462E, GLN462F, GLN483E, GLN483F, GLN71E, GLN71F, GLU157E, GLU157F, GLU236E, GLU236F, GLU248E, GLU248F, GLU476E, GLU479E, GLU479F, GLY141E, GLY141F, GLY148E, GLY148F, GLY250E, GLY250F, GLY258E, GLY258F, GLY426E, GLY426F, GLY449E, GLY449F, GLY460E, GLY460F, GLY466E, GLY466F, GLY467E, GLY467F, GLY472E, GLY472F, GLY474E, GLY474F, GLY478E, GLY478F, GLY73E, GLY73F, HIS140E, HIS140F, HIS156E, HIS156F, ILE144E, ILE144F, ILE146E, ILE146F, ILE249E, ILE249F, ILE253E, ILE253F, LEU262E, LEU262F, LEU267E, LEU267F, LEU269E, LEU269F, LEU427E, LEU427F, LEU436E, LEU436F, LEU442E, LEU442F, LEU446E, LEU446F, LEU477E, LEU477F, LEU72E, LEU72F, LYS127E, LYS127F, LYS142E, LYS142F, LYS263E, LYS263F, LYS469E, LYS469F, LYS487E, LYS487F, LYS489E, LYS489F, LYS494E, LYS494F, LYS498E, LYS498F, MET124E, MET124F, MET470E, MET470F, PHE150E, PHE150F, PHE151E, PHE151F, PHE243F, PHE432E, PHE432F, PHE459E, PHE459F, PHE465E, PHE465F, PHE70E, PHE70F, PRO145E, PRO145F, PRO158E, PRO158F, PRO464E, PRO464F, SER152E, SER152F, SER246E, SER246F, SER259E, SER259F, SER260E, SER260F, SER443E, SER443F, SER463E, SER463F, SER471E, SER471F, SER473E, SER473F, THR143E, THR143F, THR154E, THR154F, THR247E, THR247F, THR266E, THR266F, THR424E, THR424F, THR433E, THR433F, THR450E, THR450F, THR486E, THR486F, THR490E, THR490F, THR492E, THR492F, TRP135E, TRP135F, TRP285E, TRP285F, TRP452E, TRP452F, TYR131E, TYR131F, TYR139E, TYR139F, TYR153E, TYR153F, TYR425E, TYR425F, TYR441E, TYR441F, TYR456E, TYR456F, TYR468E, TYR468F, TYR480E, TYR480F, VAL159E, VAL159F, VAL252E, VAL252F, VAL255E, VAL255F, VAL265E, VAL265F, VAL417E, VAL417F, VAL431E, VAL431F, VAL451E, VAL451F, VAL453E, VAL453F, VAL458E, VAL458F, VAL488E, VAL488F, VAL491E, VAL491F, VAL493E, VAL493F, VAL495E, VAL495F
• E-G: ALA133E, ALA133G, ALA136E, ALA136G, ALA184E, ALA184G, ALA439E, ALA439G, ALA445E, ALA445G, ALA461E, ALA461G, ALA81E, ALA81G, ALA92E, ALA92G, ARG130E, ARG130G, ARG86E, ARG86G, ASN440E, ASN440G, ASN499E, ASN499G, ASN89E, ASN89G, ASP137E, ASP137G, ASP149G, ASP435E, ASP435G, ASP437E, ASP437G, ASP80E, ASP80G, ASP93E, ASP93G, CYS128E, CYS128G, GLN444E, GLN444G, GLN462E, GLN462G, GLN497E, GLN497G, GLU479E, GLU479G, GLU96E, GLU96G, GLY134E, GLY134G, GLY141E, GLY478E, GLY478G, GLY85E, GLY85G, HIS140E, HIS140G, HIS83E, HIS83G, ILE413E, ILE413G, LEU126E, LEU126G, LEU129E, LEU129G, LEU436E, LEU436G, LEU442E, LEU442G, LEU482E, LEU482G, LYS127E, LYS127G, LYS138E, LYS138G, LYS142E, LYS438E, LYS438G, LYS494E, LYS494G, LYS498E, LYS498G, PHE150E, PHE150G, PHE151E, PHE151G, PRO464E, PRO464G, PRO496E, PRO496G, SER443E, SER443G, SER463E, SER463G, SER500E, SER500G, SER82E, SER82G, THR143E, THR143G, TRP135E, TRP135G, TYR131E, TYR131G, TYR132E, TYR132G, TYR139E, TYR139G, TYR153E, TYR153G, TYR441E, TYR441G, TYR468E, TYR480E, TYR480G, VAL491G, VAL493E, VAL493G, VAL495E, VAL495G
• E-H: ALA136E, ALA136H, ALA184E, ALA184H, ALA439E, ALA439H, ALA81E, ALA81H, ARG155E, ARG155H, ARG77E, ARG77H, ARG78E, ARG78H, ARG84E, ARG84H, ASN187E, ASN187H, ASN440E, ASN440H, ASN454E, ASN454H, ASN499E, ASN499H, ASP137E, ASP137H, ASP147E, ASP147H, ASP149E, ASP149H, ASP280E, ASP280H, ASP282E, ASP282H, ASP435E, ASP435H, ASP437E, ASP437H, ASP80E, ASP80H, GLN497E, GLN497H, GLN71E, GLN71H, GLU157E, GLU157H, GLY141E, GLY141H, GLY148E, GLY148H, GLY186E, GLY186H, GLY73E, GLY73H, HIS140E, HIS140H, HIS156E, HIS156H, HIS83E, HIS83H, ILE144E, ILE144H, ILE146E, ILE146H, LEU436E, LEU436H, LEU72E, LEU72H, LYS138E, LYS138H, LYS142E, LYS142H, LYS434E, LYS434H, LYS438E, LYS438H, LYS489E, LYS489H, LYS498E, LYS498H, MET79E, MET79H, PHE150E, PHE150H, PHE151E, PHE151H, PHE432E, PHE432H, PHE70E, PHE70H, PRO145E, PRO145H, PRO158E, PRO158H, PRO496E, PRO496H, PRO75E, PRO75H, SER152E, SER152H, SER500E, SER500H, SER74E, SER74H, SER82E, SER82H, THR143E, THR143H, THR154E, THR154H, THR185E, THR185H, THR433E, THR433H, THR490E, THR490H, TRP135E, TRP135H, TRP76E, TRP76H, TYR139E, TYR139H, TYR153E, TYR153H, VAL188H, VAL431E, VAL431H, VAL453E, VAL453H, VAL491E, VAL491H, VAL493E, VAL493H, VAL495E, VAL495H
• E-I: ALA10E, ALA31I, ALA7E, ARG34I, ARG377I, ARG97E, ARG99E, ASN12E, ASN12I, ASN20I, ASN333E, ASP30I, ASP336E, ASP98E, CYS19I, CYS49I, GLN13E, GLN14E, GLN14I, GLN21I, GLN50I, GLU16E, GLU16I, GLU46I, GLU96E, ILE48I, LEU199I, LYS338E, PHE18E, PHE18I, PHE335E, PRO11E, PRO15E, PRO15I, PRO38I, PRO9E, SER337E, THR100E, THR339E, THR36I, THR39I, THR44I, TYR101E, TYR114E, TYR118E, TYR203E, VAL17I, VAL32I, VAL330E, VAL47I, VAL51I, VAL8E
• F-G: ALA136F, ALA136G, ALA184F, ALA439F, ALA439G, ALA81F, ALA81G, ARG155F, ARG155G, ARG77F, ARG77G, ARG78F, ARG78G, ARG84F, ARG84G, ASN187F, ASN187G, ASN440F, ASN440G, ASN454F, ASN454G, ASN499F, ASN499G, ASP137F, ASP137G, ASP147F, ASP147G, ASP149F, ASP149G, ASP280G, ASP282F, ASP282G, ASP435F, ASP435G, ASP437F, ASP437G, ASP80F, ASP80G, GLN497F, GLN497G, GLN71F, GLN71G, GLU157F, GLU157G, GLY141F, GLY141G, GLY148F, GLY148G, GLY160F, GLY186F, GLY186G, GLY73F, GLY73G, HIS140F, HIS140G, HIS156F, HIS156G, HIS83F, HIS83G, ILE144F, ILE144G, ILE146F, ILE146G, LEU436F, LEU436G, LEU72F, LEU72G, LYS138F, LYS138G, LYS142F, LYS142G, LYS434F, LYS434G, LYS438F, LYS438G, LYS489F, LYS489G, LYS498F, LYS498G, MET79F, MET79G, PHE150F, PHE150G, PHE151F, PHE151G, PHE432F, PHE432G, PHE70F, PHE70G, PRO145F, PRO145G, PRO158F, PRO158G, PRO496F, PRO496G, SER152F, SER152G, SER500F, SER500G, SER74F, SER74G, SER82F, SER82G, THR143F, THR143G, THR154F, THR154G, THR185F, THR185G, THR433F, THR433G, THR490F, THR490G, TRP135F, TRP135G, TRP76F, TRP76G, TYR139F, TYR139G, TYR153F, TYR153G, VAL431F, VAL431G, VAL453F, VAL453G, VAL491F, VAL491G, VAL493F, VAL493G, VAL495F, VAL495G
• F-H: ALA133F, ALA133H, ALA136F, ALA136H, ALA184F, ALA184H, ALA439F, ALA439H, ALA445F, ALA445H, ALA461F, ALA461H, ALA81F, ALA81H, ALA92F, ALA92H, ARG130F, ARG130H, ARG86F, ARG86H, ASN440F, ASN440H, ASN499F, ASN499H, ASN89F, ASN89H, ASP137F, ASP137H, ASP149F, ASP149H, ASP435F, ASP435H, ASP437F, ASP437H, ASP80F, ASP80H, ASP93F, ASP93H, CYS128F, CYS128H, GLN444F, GLN444H, GLN462F, GLN462H, GLN497F, GLN497H, GLU479F, GLU479H, GLU96F, GLU96H, GLY134F, GLY134H, GLY141H, GLY478F, GLY478H, GLY85F, GLY85H, HIS140F, HIS140H, HIS83F, HIS83H, ILE413F, ILE413H, LEU126F, LEU126H, LEU129F, LEU129H, LEU436F, LEU436H, LEU442F, LEU442H, LEU482F, LEU482H, LYS127F, LYS127H, LYS138F, LYS138H, LYS142H, LYS438F, LYS438H, LYS494F, LYS494H, LYS498F, LYS498H, PHE150F, PHE150H, PHE151F, PHE151H, PRO464F, PRO464H, PRO496F, PRO496H, SER443F, SER443H, SER463F, SER463H, SER500F, SER500H, SER82F, SER82H, THR143F, THR143H, TRP135F, TRP135H, TYR131F, TYR131H, TYR132F, TYR132H, TYR139F, TYR139H, TYR153F, TYR153H, TYR441F, TYR441H, TYR468H, TYR480F, TYR480H, VAL493F, VAL493H, VAL495F, VAL495H
• G-H: ALA256G, ALA256H, ALA257G, ALA257H, ALA428G, ALA428H, ALA429G, ALA429H, ALA430G, ALA430H, ALA439G, ALA439H, ALA445G, ALA445H, ALA448G, ALA448H, ALA461G, ALA461H, ARG155G, ARG155H, ARG251G, ARG251H, ARG264G, ARG264H, ARG475G, ARG475H, ARG67G, ARG67H, ARG77G, ARG77H, ARG78G, ARG78H, ASN261G, ASN261H, ASN421G, ASN421H, ASN440G, ASN440H, ASN454G, ASN454H, ASP123G, ASP123H, ASP147G, ASP147H, ASP149G, ASP149H, ASP237H, ASP239G, ASP239H, ASP282G, ASP282H, ASP457G, ASP457H, CYS455G, CYS455H, GLN254G, GLN254H, GLN289G, GLN289H, GLN444G, GLN444H, GLN447G, GLN447H, GLN462G, GLN462H, GLN483G, GLN483H, GLN71G, GLN71H, GLU157G, GLU157H, GLU236G, GLU236H, GLU248G, GLU248H, GLU414G, GLU476G, GLU476H, GLU479G, GLU479H, GLY141G, GLY141H, GLY148G, GLY148H, GLY250G, GLY250H, GLY258G, GLY258H, GLY426G, GLY426H, GLY449G, GLY449H, GLY460G, GLY460H, GLY466G, GLY466H, GLY467G, GLY467H, GLY472G, GLY472H, GLY474G, GLY474H, GLY478G, GLY478H, GLY73G, GLY73H, HIS140G, HIS140H, HIS156G, HIS156H, ILE144G, ILE144H, ILE146G, ILE146H, ILE249G, ILE249H, ILE253G, ILE253H, LEU262G, LEU262H, LEU267G, LEU267H, LEU269G, LEU269H, LEU427G, LEU427H, LEU436G, LEU436H, LEU442G, LEU442H, LEU446G, LEU446H, LEU477G, LEU477H, LEU72G, LEU72H, LYS127G, LYS127H, LYS142G, LYS142H, LYS263G, LYS263H, LYS469G, LYS469H, LYS487G, LYS487H, LYS489G, LYS489H, LYS494G, LYS494H, LYS498G, LYS498H, MET470G, MET470H, PHE150G, PHE150H, PHE151G, PHE151H, PHE243G, PHE243H, PHE432G, PHE432H, PHE459G, PHE459H, PHE465G, PHE465H, PHE70G, PHE70H, PRO145G, PRO145H, PRO158G, PRO158H, PRO464G, PRO464H, SER152G, SER152H, SER246G, SER246H, SER259G, SER259H, SER260G, SER260H, SER443G, SER443H, SER463G, SER463H, SER471G, SER471H, SER473G, SER473H, THR143G, THR143H, THR154G, THR154H, THR247G, THR247H, THR266G, THR266H, THR424G, THR424H, THR433G, THR433H, THR450G, THR450H, THR486G, THR486H, THR490G, THR490H, THR492G, THR492H, TRP135G, TRP135H, TRP285G, TRP285H, TRP452G, TRP452H, TYR131G, TYR131H, TYR139G, TYR139H, TYR153G, TYR153H, TYR425G, TYR425H, TYR441G, TYR441H, TYR456G, TYR456H, TYR468G, TYR468H, TYR480G, TYR480H, VAL159G, VAL159H, VAL241H, VAL252G, VAL252H, VAL255G, VAL255H, VAL265G, VAL265H, VAL417G, VAL417H, VAL431G, VAL431H, VAL451G, VAL451H, VAL453G, VAL453H, VAL458G, VAL458H, VAL488G, VAL488H, VAL491G, VAL491H, VAL493G, VAL493H, VAL495G, VAL495H
• G-K: ALA31G, ARG34G, ASN12K, ASP30G, GLN13K, GLN14K, GLN21G, GLU16K, LEU108K, PHE18K, PRO15K, SER33G, THR36G, TYR101K, VAL17K
• I-J: ALA256I, ALA256J, ALA257I, ALA257J, ALA428I, ALA428J, ALA429I, ALA429J, ALA430I, ALA430J, ALA439I, ALA439J, ALA445I, ALA445J, ALA448I, ALA448J, ALA461I, ALA461J, ARG155I, ARG155J, ARG251I, ARG251J, ARG264I, ARG264J, ARG475I, ARG475J, ARG67I, ARG67J, ARG77I, ARG77J, ARG78I, ARG78J, ASN261I, ASN261J, ASN421I, ASN421J, ASN440I, ASN440J, ASN454I, ASN454J, ASP123I, ASP123J, ASP147I, ASP147J, ASP149I, ASP149J, ASP239I, ASP239J, ASP282I, ASP282J, ASP457I, ASP457J, CYS455I, CYS455J, GLN254I, GLN254J, GLN289I, GLN289J, GLN444I, GLN444J, GLN447I, GLN447J, GLN462I, GLN462J, GLN483I, GLN483J, GLN71I, GLN71J, GLU157I, GLU157J, GLU236I, GLU236J, GLU248I, GLU248J, GLU476I, GLU476J, GLU479I, GLU479J, GLY141I, GLY141J, GLY148I, GLY148J, GLY250I, GLY250J, GLY258I, GLY258J, GLY426I, GLY449I, GLY449J, GLY460I, GLY460J, GLY466I, GLY466J, GLY467I, GLY467J, GLY472I, GLY472J, GLY474I, GLY474J, GLY478I, GLY478J, GLY73I, GLY73J, HIS140I, HIS140J, HIS156I, HIS156J, ILE144I, ILE144J, ILE146I, ILE146J, ILE249I, ILE249J, ILE253I, ILE253J, LEU262I, LEU262J, LEU267I, LEU267J, LEU269I, LEU269J, LEU427I, LEU427J, LEU436I, LEU436J, LEU442I, LEU442J, LEU446I, LEU446J, LEU477I, LEU477J, LEU72I, LEU72J, LYS127I, LYS127J, LYS142I, LYS142J, LYS263I, LYS263J, LYS469I, LYS469J, LYS487I, LYS487J, LYS489I, LYS489J, LYS494I, LYS494J, LYS498J, MET124I, MET124J, MET470I, MET470J, PHE150I, PHE150J, PHE151I, PHE151J, PHE243J, PHE432I, PHE432J, PHE459I, PHE459J, PHE465I, PHE465J, PHE70I, PHE70J, PRO145I, PRO145J, PRO158I, PRO158J, PRO464I, PRO464J, SER152I, SER152J, SER246I, SER246J, SER259I, SER259J, SER260I, SER260J, SER443I, SER443J, SER463I, SER463J, SER471I, SER471J, SER473I, SER473J, THR143I, THR143J, THR154I, THR154J, THR247I, THR247J, THR266I, THR266J, THR424I, THR424J, THR433I, THR450I, THR450J, THR486I, THR486J, THR490I, THR490J, THR492I, THR492J, TRP135I, TRP135J, TRP285I, TRP285J, TRP452I, TRP452J, TYR131I, TYR131J, TYR139I, TYR139J, TYR153I, TYR153J, TYR425I, TYR425J, TYR441I, TYR441J, TYR456I, TYR456J, TYR468I, TYR468J, TYR480I, TYR480J, VAL159I, VAL159J, VAL241I, VAL252I, VAL252J, VAL255I, VAL255J, VAL265I, VAL265J, VAL417I, VAL417J, VAL431I, VAL431J, VAL451I, VAL451J, VAL453I, VAL453J, VAL458I, VAL458J, VAL488I, VAL488J, VAL491I, VAL491J, VAL493I, VAL493J, VAL495I, VAL495J
• I-K: ALA133I, ALA133K, ALA136I, ALA136K, ALA184I, ALA184K, ALA439I, ALA439K, ALA445I, ALA445K, ALA461I, ALA461K, ALA81I, ALA81K, ALA92I, ALA92K, ARG130I, ARG130K, ARG86I, ARG86K, ASN440I, ASN440K, ASN499I, ASN499K, ASN89I, ASN89K, ASP137I, ASP137K, ASP149K, ASP435I, ASP435K, ASP437I, ASP437K, ASP80I, ASP80K, ASP93I, ASP93K, CYS128I, CYS128K, GLN444I, GLN444K, GLN462I, GLN462K, GLN497I, GLN497K, GLU479I, GLU479K, GLU96I, GLU96K, GLY134I, GLY134K, GLY141K, GLY478I, GLY478K, GLY85I, GLY85K, HIS140I, HIS140K, HIS83I, HIS83K, ILE413I, ILE413K, LEU126I, LEU126K, LEU129I, LEU129K, LEU436I, LEU436K, LEU442I, LEU442K, LEU482I, LEU482K, LYS127I, LYS127K, LYS138I, LYS138K, LYS142K, LYS438I, LYS438K, LYS494I, LYS494K, LYS498I, LYS498K, PHE150I, PHE150K, PHE151I, PHE151K, PRO464I, PRO464K, PRO496I, PRO496K, SER443I, SER443K, SER463I, SER463K, SER500I, SER500K, SER82I, SER82K, THR143I, THR143K, TRP135I, TRP135K, TYR131I, TYR131K, TYR132I, TYR132K, TYR139I, TYR139K, TYR153I, TYR153K, TYR441I, TYR441K, TYR480I, TYR480K, VAL493I, VAL493K, VAL495I, VAL495K
• I-L: ALA136I, ALA136L, ALA184L, ALA439I, ALA439L, ALA81I, ALA81L, ARG155I, ARG155L, ARG77I, ARG77L, ARG78I, ARG78L, ARG84I, ARG84L, ASN187I, ASN187L, ASN440I, ASN440L, ASN454I, ASN454L, ASN499I, ASN499L, ASP137I, ASP137L, ASP147I, ASP147L, ASP149I, ASP149L, ASP280I, ASP280L, ASP282I, ASP282L, ASP435I, ASP435L, ASP437I, ASP437L, ASP80I, ASP80L, CYS455I, GLN497I, GLN497L, GLN71I, GLN71L, GLU157I, GLU157L, GLY141I, GLY141L, GLY148I, GLY148L, GLY160I, GLY186I, GLY186L, GLY73I, GLY73L, HIS140I, HIS140L, HIS156I, HIS156L, HIS83I, HIS83L, ILE144I, ILE144L, ILE146I, ILE146L, LEU436I, LEU436L, LEU72I, LEU72L, LYS138I, LYS138L, LYS142I, LYS142L, LYS434I, LYS434L, LYS438I, LYS438L, LYS489I, LYS489L, LYS498I, LYS498L, MET79I, MET79L, PHE150I, PHE150L, PHE151I, PHE151L, PHE432I, PHE432L, PHE70I, PHE70L, PRO145I, PRO145L, PRO158I, PRO158L, PRO496I, PRO496L, PRO75L, SER152I, SER152L, SER443L, SER500I, SER500L, SER74I, SER74L, SER82I, SER82L, THR143I, THR143L, THR154I, THR154L, THR185I, THR185L, THR433I, THR433L, THR490I, THR490L, TRP135I, TRP135L, TRP76I, TRP76L, TYR139I, TYR139L, TYR153I, TYR153L, VAL431I, VAL431L, VAL453I, VAL453L, VAL491I, VAL491L, VAL493I, VAL493L, VAL495I, VAL495L
• J-K: ALA136J, ALA136K, ALA184J, ALA184K, ALA439J, ALA439K, ALA81J, ALA81K, ARG155J, ARG155K, ARG77J, ARG77K, ARG78J, ARG78K, ARG84J, ARG84K, ASN187J, ASN187K, ASN440J, ASN440K, ASN454J, ASN454K, ASN499J, ASN499K, ASP137J, ASP137K, ASP147J, ASP147K, ASP149J, ASP149K, ASP280J, ASP280K, ASP282J, ASP282K, ASP435J, ASP435K, ASP437J, ASP437K, ASP80J, ASP80K, GLN497J, GLN497K, GLN71J, GLN71K, GLU157J, GLU157K, GLY141J, GLY141K, GLY148J, GLY148K, GLY186J, GLY186K, GLY73J, GLY73K, HIS140J, HIS140K, HIS156J, HIS156K, HIS83J, HIS83K, ILE144J, ILE144K, ILE146J, ILE146K, LEU436J, LEU436K, LEU72J, LEU72K, LYS138J, LYS138K, LYS142J, LYS142K, LYS434J, LYS434K, LYS438J, LYS438K, LYS489J, LYS489K, LYS498J, LYS498K, MET79J, MET79K, PHE150J, PHE150K, PHE151J, PHE151K, PHE432J, PHE432K, PHE70J, PHE70K, PRO145J, PRO145K, PRO158J, PRO158K, PRO496J, PRO496K, PRO75J, SER152J, SER152K, SER500J, SER500K, SER74J, SER74K, SER82J, SER82K, THR143J, THR143K, THR154J, THR154K, THR185J, THR185K, THR433J, THR433K, THR490J, THR490K, TRP135J, TRP135K, TRP76J, TRP76K, TYR139J, TYR139K, TYR153J, TYR153K, VAL188K, VAL431J, VAL431K, VAL453J, VAL453K, VAL491J, VAL491K, VAL493J, VAL493K, VAL495J, VAL495K
• J-L: ALA133J, ALA133L, ALA136J, ALA136L, ALA184J, ALA184L, ALA439J, ALA439L, ALA445J, ALA445L, ALA461J, ALA461L, ALA81J, ALA81L, ALA92J, ALA92L, ARG130J, ARG130L, ARG86J, ARG86L, ASN440J, ASN440L, ASN499J, ASN499L, ASN89J, ASN89L, ASP137J, ASP137L, ASP149J, ASP149L, ASP435J, ASP435L, ASP437J, ASP437L, ASP80J, ASP80L, ASP93J, ASP93L, CYS128J, CYS128L, GLN444J, GLN444L, GLN462J, GLN462L, GLN497J, GLN497L, GLU479J, GLU479L, GLU96J, GLU96L, GLY134J, GLY134L, GLY478J, GLY478L, GLY85J, GLY85L, HIS140J, HIS140L, HIS83J, HIS83L, ILE413J, ILE413L, LEU126J, LEU126L, LEU129J, LEU129L, LEU436J, LEU436L, LEU442J, LEU442L, LEU482J, LEU482L, LYS127J, LYS127L, LYS138J, LYS138L, LYS438J, LYS438L, LYS494J, LYS494L, LYS498J, LYS498L, PHE150J, PHE150L, PHE151J, PHE151L, PRO464J, PRO464L, PRO496J, PRO496L, SER443J, SER443L, SER463J, SER463L, SER500J, SER500L, SER82J, SER82L, THR143J, THR143L, TRP135J, TRP135L, TYR131J, TYR131L, TYR132J, TYR132L, TYR139J, TYR139L, TYR153J, TYR153L, TYR441J, TYR441L, TYR480J, TYR480L, VAL491J, VAL491L, VAL493J, VAL493L, VAL495J, VAL495L
• K-L: ALA256K, ALA256L, ALA257K, ALA257L, ALA428K, ALA428L, ALA429K, ALA429L, ALA430K, ALA430L, ALA439K, ALA439L, ALA445K, ALA445L, ALA448K, ALA448L, ALA461K, ALA461L, ALA484L, ARG155K, ARG155L, ARG251K, ARG251L, ARG264K, ARG264L, ARG475K, ARG475L, ARG67K, ARG67L, ARG77K, ARG77L, ARG78K, ARG78L, ASN261K, ASN261L, ASN421K, ASN421L, ASN440K, ASN440L, ASN454K, ASN454L, ASP123K, ASP123L, ASP147K, ASP147L, ASP149K, ASP149L, ASP239K, ASP239L, ASP282K, ASP282L, ASP457K, ASP457L, CYS455K, CYS455L, GLN254K, GLN254L, GLN289K, GLN289L, GLN444K, GLN444L, GLN447K, GLN447L, GLN462K, GLN462L, GLN483K, GLN483L, GLN71K, GLN71L, GLU157K, GLU157L, GLU236K, GLU236L, GLU248K, GLU248L, GLU476K, GLU476L, GLU479K, GLU479L, GLY141K, GLY141L, GLY148K, GLY148L, GLY250K, GLY250L, GLY258K, GLY258L, GLY418K, GLY426K, GLY426L, GLY449K, GLY449L, GLY460K, GLY460L, GLY466K, GLY466L, GLY467K, GLY467L, GLY472K, GLY472L, GLY474K, GLY474L, GLY478K, GLY478L, GLY73K, GLY73L, HIS140K, HIS140L, HIS156K, HIS156L, ILE144K, ILE144L, ILE146K, ILE146L, ILE249K, ILE249L, ILE253K, ILE253L, LEU262K, LEU262L, LEU267K, LEU267L, LEU269K, LEU269L, LEU427K, LEU427L, LEU436K, LEU436L, LEU442K, LEU442L, LEU446K, LEU446L, LEU477K, LEU477L, LEU72K, LEU72L, LYS127K, LYS127L, LYS142K, LYS142L, LYS263K, LYS263L, LYS469K, LYS469L, LYS487K, LYS487L, LYS489K, LYS489L, LYS494K, LYS494L, LYS498K, LYS498L, MET124L, MET470K, MET470L, PHE150K, PHE150L, PHE151K, PHE151L, PHE243K, PHE432K, PHE432L, PHE459K, PHE459L, PHE465K, PHE465L, PHE70K, PHE70L, PRO145K, PRO145L, PRO158K, PRO158L, PRO464K, PRO464L, SER152K, SER152L, SER246K, SER246L, SER259K, SER259L, SER260K, SER260L, SER443K, SER443L, SER463K, SER463L, SER471K, SER471L, SER473K, SER473L, THR143K, THR143L, THR154K, THR154L, THR247K, THR247L, THR266K, THR266L, THR424K, THR424L, THR433K, THR433L, THR450K, THR450L, THR486K, THR486L, THR490K, THR490L, THR492K, THR492L, TRP135K, TRP135L, TRP285K, TRP285L, TRP452K, TRP452L, TYR131K, TYR131L, TYR139K, TYR139L, TYR153K, TYR153L, TYR425K, TYR425L, TYR441K, TYR441L, TYR456K, TYR456L, TYR468K, TYR468L, TYR480K, TYR480L, VAL159K, VAL159L, VAL241K, VAL241L, VAL252K, VAL252L, VAL255K, VAL255L, VAL265K, VAL265L, VAL417K, VAL417L, VAL431K, VAL431L, VAL451K, VAL451L, VAL453K, VAL453L, VAL458K, VAL458L, VAL488K, VAL488L, VAL491K, VAL491L, VAL493K, VAL493L, VAL495K, VAL495L