2OM1

structure of human insulin in presence of thiocyanate at ph 6.5

• Total interactions analyzed: 630
• Total true interactions: 140
• Strongest Interaction:
  • Chains: d-h
  • Int. Res.: 55
  • Norm. En. per Res.: -5.5252
• Hub Node: B(14)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-20.2067	-16.8952	496.803	459.7012	48	20	7	6262	1	2	2
A-D	0.0	0.0	-8.2944	-8.2944	11	6	0	344	0	0	1
A-F	0.0	0.0	-34.2325	-34.2325	17	0	2	1265	0	0	0
A-G	0.0	0.0	-3.5378	-3.5378	7	1	1	210	0	0	1
A-H	0.0	0.0	-8.5633	-8.5633	14	0	2	498	0	0	0
B-C	0.0	0.0	-7.6721	-7.6721	13	0	0	319	0	0	1
B-D	-66.1432	-0.9775	-233.73	-300.8507	56	10	6	7200	0	7	5
B-F	0.0	12.3243	-29.1329	-16.8086	23	1	1	1234	0	3	3
B-G	0.0	0.0	-10.0593	-10.0593	15	0	2	530	0	0	0
B-H	0.0	-5.752	-14.8107	-20.5627	17	0	3	1027	0	2	2
B-I	-6.6885	0.0	-45.0839	-51.7724	17	1	1	1571	0	0	0
B-J	0.0	11.8446	-39.7248	-27.8802	24	2	1	1714	0	3	3
C-D	-23.7557	-31.3845	1166.09	1110.9498	49	16	8	5592	2	3	2
C-I	0.0	0.0	-1.8557	-1.8557	7	0	0	196	0	0	0
C-J	0.0	0.0	-11.023	-11.023	14	0	0	571	0	0	0
C-L	0.0	0.0	-36.4106	-36.4106	16	0	1	1366	0	0	0
C-U	0.0	0.0	-53.4398	-53.4398	18	1	0	1278	0	0	2
C-V	0.0	0.0	-3.5608	-3.5608	12	2	0	320	0	0	0
C-X	0.0	44.0533	-42.8371	1.2162	14	1	3	1519	0	0	1
C-Y	0.0	0.0	-3.085	-3.085	6	0	0	239	0	1	1
D-G	0.0	0.0	-45.6882	-45.6882	17	0	1	1538	0	0	0
D-H	0.0	11.6653	-27.0176	-15.3523	23	1	1	1163	0	3	3
D-I	0.0	0.0	-9.9583	-9.9583	16	0	2	486	0	0	0
D-J	0.0	19.9161	-17.9258	1.9903	18	2	3	1021	0	2	2
D-L	0.0	11.4865	-26.2762	-14.7897	23	1	1	1097	0	3	3
D-U	0.0	0.0	-0.0379	-0.0379	2	0	0	13	0	0	0
D-X	0.0	0.0	-2.3844	-2.3844	7	0	0	181	0	1	1
D-Y	0.0	0.0	-0.2016	-0.2016	2	0	0	40	0	2	1
E-F	-24.4598	-37.8043	1224.94	1162.676	49	12	9	6391	2	3	2
E-H	0.0	0.0	-8.1875	-8.1875	12	0	0	302	0	0	1
E-J	-7.5097	0.0	-42.8278	-50.3375	16	0	1	1468	0	0	0
E-K	0.0	0.0	-2.2203	-2.2203	7	0	0	205	0	0	0
E-L	0.0	0.0	-11.392	-11.392	14	1	1	569	0	0	0
F-G	0.0	0.0	-4.6199	-4.6199	9	2	0	222	0	0	1
F-H	-48.519	-0.0706	-224.26	-272.8496	57	7	7	6875	0	7	5
F-J	0.0	11.524	-45.5999	-34.0759	24	2	1	1654	0	3	3
F-K	0.0	0.0	-9.6339	-9.6339	16	0	2	538	0	0	0
F-L	0.0	-6.1855	-16.9152	-23.1007	17	0	3	993	0	2	2
G-H	-14.5209	-27.3474	1373.71	1331.8417	48	12	8	6119	2	2	2
H-K	-9.8357	0.0	-45.5589	-55.3946	17	1	1	1563	0	0	0
H-L	0.0	11.3911	-44.9522	-33.5611	23	2	1	1656	0	3	3
I-J	-19.3866	-31.8012	1309.46	1258.2722	49	15	8	6584	2	3	2
I-L	0.0	0.0	-8.8098	-8.8098	11	1	0	307	0	0	1
I-X	-19.242	0.0	-48.5111	-67.7531	19	3	0	1290	0	0	2
I-Y	0.0	0.0	-0.0283	-0.0283	2	0	0	10	0	0	0
J-K	0.0	0.0	8.4246	8.4246	12	4	0	304	0	0	1
J-L	-48.6506	7.6402	-219.43	-260.4404	58	8	7	6948	0	8	6
J-V	0.0	0.0	-0.0474	-0.0474	2	0	0	4	0	0	1
J-X	0.0	0.0	-4.5168	-4.5168	11	1	0	276	0	0	0
K-L	-17.7821	-42.9434	1356.47	1295.7445	49	16	9	6749	4	3	2
Q-R	-16.4617	-33.7165	1398.52	1348.3418	50	14	9	6742	2	3	2
Q-T	-7.8493	0.0	-40.8771	-48.7264	17	0	1	1465	0	0	0
Q-Y	0.0	0.0	-8.7224	-8.7224	11	1	0	322	0	0	1
Q-1	0.0	0.0	-1.8822	-1.8822	7	0	0	202	0	0	0
Q-2	0.0	0.0	-9.6169	-9.6169	16	0	2	545	0	0	0
R-T	0.0	11.8551	-52.5211	-40.666	24	1	1	1808	0	3	3
R-U	0.0	0.0	-40.7581	-40.7581	17	0	1	1450	0	0	0
R-V	0.0	11.4054	-33.492	-22.0866	23	3	1	1312	0	3	3
R-X	0.0	0.0	-4.652	-4.652	10	0	0	193	0	0	1
R-Y	-63.8654	-0.4674	-221.457	-285.7898	57	8	7	6994	0	8	6
R-1	0.0	0.0	-11.4345	-11.4345	14	1	1	575	0	0	0
R-2	0.0	7.3164	-21.9314	-14.615	19	1	3	1133	0	2	2
S-T	-14.8021	-31.4008	1200.87	1154.6671	49	16	8	6227	2	3	2
S-V	0.0	0.0	-37.8041	-37.8041	16	0	1	1288	0	0	0
S-1	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
S-2	0.0	0.0	-8.47	-8.47	13	2	0	309	0	0	1
S-3	0.0	0.0	-1.8097	-1.8097	7	0	0	186	0	0	0
S-4	0.0	0.0	-11.3326	-11.3326	14	1	0	576	0	0	0
S-e	-9.6324	0.0	-58.6217	-68.2541	18	1	0	1324	0	0	2
S-f	0.0	0.0	-6.7295	-6.7295	11	1	0	366	0	1	0
S-g	0.0	41.2861	-46.11	-4.8239	14	1	3	1571	0	0	1
S-h	0.0	0.0	-4.2097	-4.2097	7	0	0	259	0	1	1
T-V	0.0	11.2578	-40.44	-29.1822	24	2	1	1551	0	3	3
T-1	0.0	0.0	-7.2488	-7.2488	13	3	0	315	0	0	1
T-2	-57.8203	-8.5367	-230.152	-296.509	56	10	6	7354	1	8	6
T-3	0.0	0.0	-10.2353	-10.2353	16	0	2	525	0	0	0
T-4	0.0	-6.316	-16.6616	-22.9776	17	0	3	918	0	2	2
T-e	0.0	0.0	-0.0391	-0.0391	3	0	0	17	0	0	0
T-g	0.0	0.0	-3.3045	-3.3045	6	0	0	234	0	1	0
T-h	0.0	0.0	-0.1164	-0.1164	2	0	0	28	0	0	1
U-V	-24.1294	-41.6162	375.528	309.7824	48	12	8	6227	2	3	2
U-X	0.0	0.0	-1.7883	-1.7883	7	0	0	182	0	0	1
U-Y	0.0	0.0	-10.798	-10.798	16	0	2	534	0	0	0
U-4	0.0	0.0	-4.5421	-4.5421	11	0	0	189	0	0	1
V-X	0.0	0.0	-10.8124	-10.8124	14	0	0	551	0	0	0
V-Y	0.0	7.59	-20.903	-13.313	17	0	3	1039	0	2	2
V-3	0.0	0.0	-6.9168	-6.9168	11	0	0	284	0	0	1
V-4	-47.4912	-6.924	-220.813	-275.2282	53	10	6	7203	0	8	6
X-Y	-12.876	-34.1001	1063.7	1016.7239	48	20	8	6004	2	3	2
X-4	0.0	0.0	-42.939	-42.939	16	0	1	1506	0	0	0
Y-1	0.0	0.0	-39.8223	-39.8223	17	0	1	1428	0	0	0
Y-2	0.0	11.3309	-36.0583	-24.7274	24	6	1	1738	0	3	3
Y-4	0.0	11.2393	-49.4877	-38.2484	25	1	1	1789	0	3	3
1-2	-22.4564	-32.7535	1189.35	1134.1401	48	12	9	6200	2	3	2
2-3	0.0	0.0	-47.5117	-47.5117	17	1	1	1564	0	0	0
2-4	0.0	11.557	-42.4439	-30.8869	24	6	1	1793	0	3	3
3-4	-14.3236	-33.2474	1282.17	1234.599	48	13	9	6506	2	3	2
3-g	0.0	0.0	-52.7705	-52.7705	18	1	0	1228	0	0	2
3-h	0.0	0.0	-0.0368	-0.0368	3	0	0	16	0	0	0
4-f	0.0	0.0	-0.0075	-0.0075	2	0	0	1	0	0	1
4-g	0.0	0.0	-5.4377	-5.4377	11	1	0	311	0	0	0
a-b	-22.5052	-29.5588	1324.7	1272.6361	49	17	8	6109	2	3	2
a-f	0.0	0.0	-38.2081	-38.2081	16	1	1	1439	0	0	0
a-i	0.0	0.0	-1.5666	-1.5666	7	0	0	182	0	0	0
a-j	0.0	0.0	-10.1279	-10.1279	13	0	0	523	0	0	0
a-l	-5.5184	0.0	-7.3186	-12.837	11	2	0	332	0	0	1
b-c	0.0	0.0	-29.0163	-29.0163	17	0	1	1184	0	0	0
b-d	0.0	11.3271	-28.0159	-16.6888	23	1	1	1154	0	3	3
b-f	0.0	11.3922	-23.6886	-12.2964	25	4	1	1604	0	3	3
b-i	0.0	0.0	-9.1335	-9.1335	16	0	1	518	0	0	0
b-j	0.0	17.3811	-23.1838	-5.8027	17	0	3	1089	0	2	2
b-k	0.0	0.0	-4.7309	-4.7309	9	1	0	195	0	0	1
b-l	-47.9599	0.7311	-230.331	-277.5598	56	6	7	6912	0	7	5
c-d	-13.6168	-29.0126	1170.47	1127.8405	48	20	7	5845	2	3	2
c-h	0.0	0.0	-3.2745	-3.2745	11	1	0	215	0	0	1
c-k	0.0	0.0	-2.3557	-2.3557	6	0	1	200	0	0	1
c-l	0.0	0.0	-9.275	-9.275	13	1	0	530	0	0	0
d-e	-4.5057	0.0	-46.0971	-50.6028	17	0	1	1540	0	0	0
d-f	0.0	11.7765	-37.7224	-25.9459	24	3	1	1736	0	3	3
d-g	0.0	0.0	-6.616	-6.616	13	0	0	279	0	0	1
d-h	-59.3248	-6.7148	-237.846	-303.8856	55	11	6	7459	0	8	6
d-k	0.0	0.0	-10.2244	-10.2244	15	0	2	531	0	0	0
d-l	0.0	-6.2796	-17.5062	-23.7858	18	0	3	1008	0	2	2
e-f	-15.2765	-31.6421	418.373	371.4544	48	11	9	6413	2	3	2
e-g	0.0	0.0	-1.7926	-1.7926	7	0	0	186	0	0	0
e-h	0.0	0.0	-10.5996	-10.5996	16	0	2	547	0	0	0
e-j	0.0	0.0	-8.1908	-8.1908	12	0	0	320	0	0	1
f-g	0.0	0.0	-10.5503	-10.5503	14	1	0	530	0	0	0
f-h	0.0	15.8755	-24.2818	-8.4063	18	0	3	1113	0	2	2
f-i	0.0	0.0	11.6523	11.6523	11	6	0	340	0	0	1
f-j	-58.4178	-5.5336	-212.592	-276.5434	56	6	6	6938	1	8	6
g-h	-26.0032	-29.9735	1162.03	1106.0532	48	15	8	6459	2	3	2
g-j	0.0	0.0	-41.4198	-41.4198	17	0	1	1522	0	0	0
h-j	0.0	11.8557	-31.7137	-19.858	25	1	1	1535	0	3	3
h-k	0.0	0.0	-41.2164	-41.2164	18	0	1	1489	0	0	0
h-l	0.0	11.6097	-50.5505	-38.9408	24	3	1	1822	0	3	3
i-j	-16.7717	-33.6792	1258.46	1208.009	48	17	9	6755	2	3	2
i-l	-5.1317	0.0	-39.0519	-44.1836	17	3	1	1569	0	0	0
j-l	0.0	11.1499	-48.5503	-37.4004	24	6	1	1752	0	3	3
k-l	-12.4384	-27.609	1364.1	1324.0527	47	13	8	5721	1	2	2

Interface residues

• A-B: ALA14B, ARG22B, ASN18A, ASN21A, ASN3B, CYS11A, CYS19B, CYS20A, CYS6A, CYS7A, CYS7B, GLN15A, GLN4B, GLN5A, GLU13B, GLU17A, GLU21B, GLU4A, GLY1A, GLY20B, GLY23B, GLY8B, HIS10B, HIS5B, ILE10A, ILE2A, LEU11B, LEU13A, LEU15B, LEU16A, LEU17B, LEU6B, LYS29B, PHE24B, PHE25B, PRO28B, SER12A, SER9A, SER9B, THR27B, THR8A, TYR14A, TYR16B, TYR19A, TYR26B, VAL12B, VAL18B, VAL3A
• A-D: ASN21A, CYS20A, ILE2A, LYS29D, PHE25D, PRO28D, THR27D, TYR16D, TYR19A, TYR26D, VAL3A
• A-F: ASN3F, CYS11A, CYS6A, CYS7A, GLN4F, GLN5A, HIS5F, ILE10A, LEU13A, LEU16A, LEU6F, PHE1F, SER12A, SER9A, THR8A, VAL2F, VAL3A
• A-G: GLU17A, GLU17G, LEU13A, LEU13G, LEU16A, LEU16G, TYR14G
• A-H: ALA14H, ARG22H, CYS11A, CYS19H, GLU21H, GLY20H, ILE10A, LEU13A, LEU15H, LEU16A, LEU17H, SER12A, TYR16H, VAL18H
• B-C: ASN21C, CYS20C, GLU21B, ILE2C, LYS29B, PHE24B, PHE25B, PRO28B, THR27B, TYR16B, TYR19C, TYR26B, VAL3C
• B-D: ALA14B, ALA14D, ARG22B, ARG22D, ASN3B, ASN3D, CYS19B, CYS19D, CYS7B, CYS7D, GLN4B, GLN4D, GLU13B, GLU13D, GLU21B, GLU21D, GLY20B, GLY20D, GLY23B, GLY23D, GLY8B, GLY8D, HIS10B, HIS10D, HIS5B, HIS5D, LEU11B, LEU11D, LEU15B, LEU15D, LEU17B, LEU17D, LEU6B, LEU6D, LYS29B, LYS29D, PHE1D, PHE24B, PHE24D, PHE25B, PHE25D, PRO28B, PRO28D, SER9B, SER9D, THR27B, THR27D, TYR16B, TYR16D, TYR26B, TYR26D, VAL12B, VAL12D, VAL18B, VAL18D, VAL2D
• B-F: ALA14B, ASN3B, ASN3F, CYS7B, CYS7F, GLN4B, GLU13B, GLU13F, GLY8B, GLY8F, HIS10B, HIS10F, HIS5B, HIS5F, LEU11B, LEU11F, LEU6B, LEU6F, PHE1B, SER9B, SER9F, VAL2B, VAL2F
• B-G: ALA14B, CYS11G, CYS19B, GLU13B, GLU21B, GLY20B, ILE10G, LEU13G, LEU15B, LEU16G, LEU17B, SER12G, TYR14G, TYR16B, VAL18B
• B-H: ALA14B, ALA14H, GLU13B, GLU13H, HIS10B, HIS10H, LEU11B, LEU11H, LEU15B, LEU15H, LEU17B, LEU17H, TYR16B, TYR16H, VAL12H, VAL18B, VAL18H
• B-I: ASN3B, CYS11I, CYS6I, CYS7I, GLN4B, GLN5I, HIS5B, ILE10I, LEU13I, LEU16I, LEU6B, PHE1B, SER12I, SER9I, THR8I, VAL2B, VAL3I
• B-J: ALA14J, ASN3B, ASN3J, CYS7B, CYS7J, GLN4J, GLU13B, GLU13J, GLY8B, GLY8J, HIS10B, HIS10J, HIS5B, HIS5J, LEU11B, LEU11J, LEU6B, LEU6J, PHE1B, PHE1J, SER9B, SER9J, VAL2B, VAL2J
• C-D: ALA14D, ARG22D, ASN18C, ASN21C, ASN3D, CYS11C, CYS19D, CYS20C, CYS6C, CYS7C, CYS7D, GLN15C, GLN4D, GLN5C, GLU13D, GLU17C, GLU21D, GLU4C, GLY1C, GLY20D, GLY23D, GLY8D, HIS10D, HIS5D, ILE10C, ILE2C, LEU11D, LEU13C, LEU15D, LEU16C, LEU17D, LEU6D, LYS29D, PHE1D, PHE24D, PHE25D, PRO28D, SER12C, SER9C, SER9D, THR27D, THR8C, TYR14C, TYR16D, TYR19C, TYR26D, VAL12D, VAL18D, VAL3C
• C-I: GLU17C, GLU17I, LEU13C, LEU13I, LEU16C, TYR14C, TYR14I
• C-J: ALA14J, ARG22J, CYS11C, CYS19J, GLU21J, GLY20J, ILE10C, LEU13C, LEU15J, LEU16C, LEU17J, SER12C, TYR16J, VAL18J
• C-L: ASN3L, CYS11C, CYS6C, CYS7C, GLN4L, GLN5C, HIS5L, ILE10C, LEU13C, LEU16C, LEU6L, PHE1L, SER9C, THR8C, VAL2L, VAL3C
• C-U: ASN18C, ASN18U, CYS20C, CYS20U, GLN15C, GLN15U, GLN5C, GLU17C, GLU17U, LEU13C, LEU13U, LEU16C, LEU16U, SER12C, SER12U, TYR14C, TYR14U, TYR19C
• C-V: ARG22V, CYS11C, CYS19V, GLN15C, GLN5C, GLY20V, ILE10C, LEU17V, SER12C, SER9C, TYR14C, VAL18V
• C-X: CYS20C, CYS20X, GLN15C, GLN15X, GLU17C, GLU17X, LEU13C, LEU13X, LEU16C, LEU16X, SER12C, SER12X, TYR14C, TYR14X
• C-Y: ARG22Y, CYS19Y, GLU17C, LEU17Y, TYR14C, VAL18Y
• D-G: ASN3D, CYS11G, CYS6G, CYS7G, GLN4D, GLN5G, HIS5D, ILE10G, LEU13G, LEU16G, LEU6D, PHE1D, SER12G, SER9G, THR8G, VAL2D, VAL3G
• D-H: ALA14H, ASN3D, ASN3H, CYS7D, CYS7H, GLN4H, GLU13D, GLU13H, GLY8D, GLY8H, HIS10D, HIS10H, HIS5D, HIS5H, LEU11D, LEU11H, LEU6D, LEU6H, PHE1H, SER9D, SER9H, VAL2D, VAL2H
• D-I: ALA14D, ARG22D, CYS11I, CYS19D, GLU13D, GLU21D, GLY20D, ILE10I, LEU13I, LEU15D, LEU16I, LEU17D, SER12I, TYR14I, TYR16D, VAL18D
• D-J: ALA14D, ALA14J, CYS19D, GLU13D, GLU13J, HIS10D, HIS10J, LEU11D, LEU11J, LEU15D, LEU15J, LEU17D, LEU17J, TYR16D, TYR16J, VAL12J, VAL18D, VAL18J
• D-L: ALA14D, ASN3D, ASN3L, CYS7D, CYS7L, GLN4D, GLU13D, GLU13L, GLY8D, GLY8L, HIS10D, HIS10L, HIS5D, HIS5L, LEU11D, LEU11L, LEU6D, LEU6L, SER9D, SER9L, VAL12L, VAL2D, VAL2L
• D-U: ARG22D, TYR14U
• D-X: ARG22D, CYS19D, GLU17X, GLY20D, LEU17D, TYR14X, VAL18D
• D-Y: ARG22D, ARG22Y
• E-F: ALA14F, ARG22F, ASN18E, ASN21E, ASN3F, CYS11E, CYS19F, CYS20E, CYS6E, CYS7E, CYS7F, GLN15E, GLN4F, GLN5E, GLU13F, GLU17E, GLU21F, GLU4E, GLY1E, GLY20F, GLY23F, GLY8F, HIS10F, HIS5F, ILE10E, ILE2E, LEU11F, LEU13E, LEU15F, LEU16E, LEU17F, LEU6F, LYS29F, PHE1F, PHE24F, PHE25F, PRO28F, SER12E, SER9E, SER9F, THR27F, THR8E, TYR14E, TYR16F, TYR19E, TYR26F, VAL12F, VAL18F, VAL3E
• E-H: ASN21E, CYS20E, GLU21H, ILE2E, PHE24H, PHE25H, PRO28H, THR27H, TYR16H, TYR19E, TYR26H, VAL3E
• E-J: ASN3J, CYS11E, CYS6E, CYS7E, GLN4J, GLN5E, HIS5J, ILE10E, LEU13E, LEU16E, LEU6J, PHE1J, SER9E, THR8E, VAL2J, VAL3E
• E-K: GLU17E, GLU17K, LEU13E, LEU13K, LEU16E, TYR14E, TYR14K
• E-L: ALA14L, ARG22L, CYS11E, CYS19L, GLU21L, GLY20L, ILE10E, LEU13E, LEU15L, LEU16E, LEU17L, SER12E, TYR16L, VAL18L
• F-G: ASN21G, CYS20G, ILE2G, PHE25F, PRO28F, THR27F, TYR16F, TYR26F, VAL3G
• F-H: ALA14F, ALA14H, ARG22F, ARG22H, ASN3F, ASN3H, CYS19F, CYS19H, CYS7F, CYS7H, GLN4F, GLN4H, GLU13F, GLU13H, GLU21F, GLU21H, GLY20F, GLY20H, GLY23F, GLY23H, GLY8F, GLY8H, HIS10F, HIS10H, HIS5F, HIS5H, LEU11F, LEU11H, LEU15F, LEU15H, LEU17F, LEU17H, LEU6F, LEU6H, LYS29F, LYS29H, PHE1F, PHE24F, PHE24H, PHE25F, PHE25H, PRO28F, PRO28H, SER9F, SER9H, THR27F, THR27H, TYR16F, TYR16H, TYR26F, TYR26H, VAL12F, VAL12H, VAL18F, VAL18H, VAL2F, VAL2H
• F-J: ALA14F, ASN3F, ASN3J, CYS7F, CYS7J, GLN4F, GLU13F, GLU13J, GLY8F, GLY8J, HIS10F, HIS10J, HIS5F, HIS5J, LEU11F, LEU11J, LEU6F, LEU6J, PHE1F, PHE1J, SER9F, SER9J, VAL2F, VAL2J
• F-K: ALA14F, ARG22F, CYS11K, CYS19F, GLU13F, GLU21F, GLY20F, ILE10K, LEU13K, LEU15F, LEU16K, LEU17F, SER12K, TYR14K, TYR16F, VAL18F
• F-L: ALA14F, ALA14L, CYS19F, GLU13F, GLU13L, HIS10F, HIS10L, LEU11F, LEU11L, LEU15F, LEU15L, LEU17F, LEU17L, TYR16F, TYR16L, VAL18F, VAL18L
• G-H: ALA14H, ARG22H, ASN18G, ASN21G, ASN3H, CYS11G, CYS19H, CYS20G, CYS6G, CYS7G, CYS7H, GLN15G, GLN4H, GLN5G, GLU13H, GLU17G, GLU21H, GLU4G, GLY1G, GLY20H, GLY23H, GLY8H, HIS10H, HIS5H, ILE10G, ILE2G, LEU11H, LEU13G, LEU15H, LEU16G, LEU17H, LEU6H, LYS29H, PHE24H, PHE25H, PRO28H, SER12G, SER9G, SER9H, THR27H, THR8G, TYR14G, TYR16H, TYR19G, TYR26H, VAL12H, VAL18H, VAL3G
• H-K: ASN3H, CYS11K, CYS6K, CYS7K, GLN4H, GLN5K, HIS5H, ILE10K, LEU13K, LEU16K, LEU6H, PHE1H, SER12K, SER9K, THR8K, VAL2H, VAL3K
• H-L: ALA14L, ASN3H, ASN3L, CYS7H, CYS7L, GLN4L, GLU13H, GLU13L, GLY8H, GLY8L, HIS10H, HIS10L, HIS5H, HIS5L, LEU11H, LEU11L, LEU6H, LEU6L, PHE1H, SER9H, SER9L, VAL2H, VAL2L
• I-J: ALA14J, ARG22J, ASN18I, ASN21I, ASN3J, CYS11I, CYS19J, CYS20I, CYS6I, CYS7I, CYS7J, GLN15I, GLN4J, GLN5I, GLU13J, GLU17I, GLU21J, GLU4I, GLY1I, GLY20J, GLY23J, GLY8J, HIS10J, HIS5J, ILE10I, ILE2I, LEU11J, LEU13I, LEU15J, LEU16I, LEU17J, LEU6J, LYS29J, PHE24J, PHE25J, PRO28J, SER12I, SER9I, SER9J, THR27J, THR30J, THR8I, TYR14I, TYR16J, TYR19I, TYR26J, VAL12J, VAL18J, VAL3I
• I-L: ASN21I, CYS20I, CYS7I, ILE2I, PHE24L, PHE25L, PRO28L, THR27L, TYR16L, TYR26L, VAL3I
• I-X: ASN18I, ASN18X, CYS11X, CYS20I, CYS20X, GLN15I, GLN15X, GLN5X, GLU17I, GLU17X, LEU13I, LEU13X, LEU16I, LEU16X, SER12I, SER12X, TYR14I, TYR14X, TYR19X
• I-Y: ARG22Y, TYR14I
• J-K: ASN21K, CYS20K, CYS7K, ILE2K, PHE24J, PHE25J, PRO28J, THR27J, TYR16J, TYR19K, TYR26J, VAL3K
• J-L: ALA14J, ALA14L, ARG22J, ARG22L, ASN3J, ASN3L, CYS19J, CYS19L, CYS7J, CYS7L, GLN4J, GLN4L, GLU13J, GLU13L, GLU21J, GLU21L, GLY20J, GLY20L, GLY23J, GLY23L, GLY8J, GLY8L, HIS10J, HIS10L, HIS5J, HIS5L, LEU11J, LEU11L, LEU15J, LEU15L, LEU17J, LEU17L, LEU6J, LEU6L, LYS29J, LYS29L, PHE1L, PHE24J, PHE24L, PHE25J, PHE25L, PRO28J, PRO28L, SER9J, SER9L, THR27J, THR27L, THR30J, TYR16J, TYR16L, TYR26J, TYR26L, VAL12J, VAL12L, VAL18J, VAL18L, VAL2J, VAL2L
• J-V: GLU21J, GLU21V
• J-X: ARG22J, CYS11X, CYS19J, GLN15X, GLN5X, ILE10X, LEU17J, SER12X, SER9X, TYR14X, VAL18J
• K-L: ALA14L, ARG22L, ASN18K, ASN21K, ASN3L, CYS11K, CYS19L, CYS20K, CYS6K, CYS7K, CYS7L, GLN15K, GLN4L, GLN5K, GLU13L, GLU17K, GLU21L, GLU4K, GLY1K, GLY20L, GLY23L, GLY8L, HIS10L, HIS5L, ILE10K, ILE2K, LEU11L, LEU13K, LEU15L, LEU16K, LEU17L, LEU6L, LYS29L, PHE1L, PHE24L, PHE25L, PRO28L, SER12K, SER9K, SER9L, THR27L, THR8K, TYR14K, TYR16L, TYR19K, TYR26L, VAL12L, VAL18L, VAL3K
• Q-R: ALA14R, ARG22R, ASN18Q, ASN21Q, ASN3R, CYS11Q, CYS19R, CYS20Q, CYS6Q, CYS7Q, CYS7R, GLN15Q, GLN4R, GLN5Q, GLU13R, GLU17Q, GLU21R, GLU4Q, GLY1Q, GLY20R, GLY23R, GLY8R, HIS10R, HIS5R, ILE10Q, ILE2Q, LEU11R, LEU13Q, LEU15R, LEU16Q, LEU17R, LEU6R, LYS29R, PHE1R, PHE24R, PHE25R, PRO28R, SER12Q, SER9Q, SER9R, THR27R, THR30R, THR8Q, TYR14Q, TYR16R, TYR19Q, TYR26R, VAL12R, VAL18R, VAL3Q
• Q-T: ASN3T, CYS11Q, CYS6Q, CYS7Q, GLN4T, GLN5Q, HIS5T, ILE10Q, LEU13Q, LEU16Q, LEU6T, PHE1T, SER12Q, SER9Q, THR8Q, VAL2T, VAL3Q
• Q-Y: ASN21Q, CYS20Q, ILE2Q, LYS29Y, PHE25Y, PRO28Y, THR27Y, TYR16Y, TYR19Q, TYR26Y, VAL3Q
• Q-1: GLU171, GLU17Q, LEU131, LEU13Q, LEU161, TYR141, TYR14Q
• Q-2: ALA142, ARG222, CYS11Q, CYS192, GLU132, GLU212, GLY202, ILE10Q, LEU13Q, LEU152, LEU16Q, LEU172, SER12Q, TYR14Q, TYR162, VAL182
• R-T: ALA14R, ASN3R, ASN3T, CYS7R, CYS7T, GLN4R, GLU13R, GLU13T, GLY8R, GLY8T, HIS10R, HIS10T, HIS5R, HIS5T, LEU11R, LEU11T, LEU6R, LEU6T, PHE1R, PHE1T, SER9R, SER9T, VAL2R, VAL2T
• R-U: ASN3R, CYS11U, CYS6U, CYS7U, GLN4R, GLN5U, HIS5R, ILE10U, LEU13U, LEU16U, LEU6R, PHE1R, SER12U, SER9U, THR8U, VAL2R, VAL3U
• R-V: ALA14V, ASN3R, ASN3V, CYS7R, CYS7V, GLN4V, GLU13R, GLU13V, GLY8R, GLY8V, HIS10R, HIS10V, HIS5R, HIS5V, LEU11R, LEU11V, LEU6R, LEU6V, PHE1V, SER9R, SER9V, VAL2R, VAL2V
• R-X: ASN21X, CYS20X, GLU21R, ILE2X, PHE25R, PRO28R, THR27R, TYR16R, TYR26R, VAL3X
• R-Y: ALA14R, ALA14Y, ARG22R, ARG22Y, ASN3R, ASN3Y, CYS19R, CYS19Y, CYS7R, CYS7Y, GLN4R, GLN4Y, GLU13R, GLU13Y, GLU21R, GLU21Y, GLY20R, GLY20Y, GLY23R, GLY23Y, GLY8R, GLY8Y, HIS10R, HIS10Y, HIS5R, HIS5Y, LEU11R, LEU11Y, LEU15R, LEU15Y, LEU17R, LEU17Y, LEU6R, LEU6Y, LYS29R, LYS29Y, PHE24R, PHE24Y, PHE25R, PHE25Y, PRO28R, PRO28Y, SER9R, SER9Y, THR27R, THR27Y, THR30R, TYR16R, TYR16Y, TYR26R, TYR26Y, VAL12R, VAL12Y, VAL18R, VAL18Y, VAL2R, VAL2Y
• R-1: ALA14R, ARG22R, CYS111, CYS19R, GLU21R, GLY20R, ILE101, LEU131, LEU15R, LEU161, LEU17R, SER121, TYR16R, VAL18R
• R-2: ALA142, ALA14R, CYS192, GLU132, GLU13R, HIS102, HIS10R, LEU112, LEU11R, LEU152, LEU15R, LEU172, LEU17R, SER92, TYR162, TYR16R, VAL12R, VAL182, VAL18R
• S-T: ALA14T, ARG22T, ASN18S, ASN21S, ASN3T, CYS11S, CYS19T, CYS20S, CYS6S, CYS7S, CYS7T, GLN15S, GLN4T, GLN5S, GLU13T, GLU17S, GLU21T, GLU4S, GLY1S, GLY20T, GLY23T, GLY8T, HIS10T, HIS5T, ILE10S, ILE2S, LEU11T, LEU13S, LEU15T, LEU16S, LEU17T, LEU6T, LYS29T, PHE24T, PHE25T, PRO28T, SER12S, SER9S, SER9T, THR27T, THR30T, THR8S, TYR14S, TYR16T, TYR19S, TYR26T, VAL12T, VAL18T, VAL3S
• S-V: ASN3V, CYS11S, CYS6S, CYS7S, GLN4V, GLN5S, HIS5V, ILE10S, LEU13S, LEU16S, LEU6V, PHE1V, SER9S, THR8S, VAL2V, VAL3S
• S-1: ASN211, ASN21S
• S-2: ASN21S, CYS20S, CYS7S, GLU212, ILE2S, PHE242, PHE252, PRO282, THR272, TYR162, TYR19S, TYR262, VAL3S
• S-3: GLU173, GLU17S, LEU133, LEU13S, LEU16S, TYR143, TYR14S
• S-4: ALA144, ARG224, CYS11S, CYS194, GLU214, GLY204, ILE10S, LEU13S, LEU154, LEU16S, LEU174, SER12S, TYR164, VAL184
• S-e: ASN18S, ASN18e, CYS11S, CYS20S, CYS20e, GLN15S, GLN15e, GLN5S, GLU17S, GLU17e, LEU13S, LEU13e, LEU16S, SER12S, SER12e, TYR14S, TYR14e, TYR19S
• S-f: ARG22f, CYS11S, CYS19f, GLN15S, GLN5S, GLY20f, LEU17f, SER12S, SER9S, TYR14S, VAL18f
• S-g: CYS20S, CYS20g, GLN15S, GLN15g, GLU17S, GLU17g, LEU13S, LEU13g, LEU16S, LEU16g, SER12S, SER12g, TYR14S, TYR14g
• S-h: ARG22h, CYS19h, GLU17S, GLY20h, LEU17h, TYR14S, VAL18h
• T-V: ALA14T, ASN3T, ASN3V, CYS7T, CYS7V, GLN4T, GLU13T, GLU13V, GLY8T, GLY8V, HIS10T, HIS10V, HIS5T, HIS5V, LEU11T, LEU11V, LEU6T, LEU6V, PHE1T, PHE1V, SER9T, SER9V, VAL2T, VAL2V
• T-1: ASN211, CYS201, CYS71, ILE21, LYS29T, PHE24T, PHE25T, PRO28T, THR27T, TYR16T, TYR191, TYR26T, VAL31
• T-2: ALA142, ALA14T, ARG222, ARG22T, ASN32, ASN3T, CYS192, CYS19T, CYS72, CYS7T, GLN42, GLN4T, GLU132, GLU13T, GLU212, GLU21T, GLY202, GLY20T, GLY232, GLY23T, GLY82, GLY8T, HIS102, HIS10T, HIS52, HIS5T, LEU112, LEU11T, LEU152, LEU15T, LEU172, LEU17T, LEU62, LEU6T, LYS292, LYS29T, PHE242, PHE24T, PHE252, PHE25T, PRO282, PRO28T, SER92, SER9T, THR272, THR27T, THR30T, TYR162, TYR16T, TYR262, TYR26T, VAL122, VAL12T, VAL182, VAL18T, VAL22
• T-3: ALA14T, ARG22T, CYS113, CYS19T, GLU13T, GLU21T, GLY20T, ILE103, LEU133, LEU15T, LEU163, LEU17T, SER123, TYR143, TYR16T, VAL18T
• T-4: ALA144, ALA14T, CYS19T, GLU134, GLU13T, HIS104, HIS10T, LEU114, LEU11T, LEU154, LEU15T, LEU174, LEU17T, TYR164, TYR16T, VAL184, VAL18T
• T-e: ARG22T, TYR14e, VAL18T
• T-g: ARG22T, CYS19T, GLU17g, LEU17T, TYR14g, VAL18T
• T-h: ARG22T, ARG22h
• U-V: ALA14V, ARG22V, ASN18U, ASN21U, ASN3V, CYS11U, CYS19V, CYS20U, CYS6U, CYS7U, CYS7V, GLN15U, GLN4V, GLN5U, GLU13V, GLU17U, GLU21V, GLU4U, GLY1U, GLY20V, GLY23V, GLY8V, HIS10V, HIS5V, ILE10U, ILE2U, LEU11V, LEU13U, LEU15V, LEU16U, LEU17V, LEU6V, LYS29V, PHE24V, PHE25V, PRO28V, SER12U, SER9U, SER9V, THR27V, THR8U, TYR14U, TYR16V, TYR19U, TYR26V, VAL12V, VAL18V, VAL3U
• U-X: GLU17U, GLU17X, LEU13U, LEU13X, LEU16X, TYR14U, TYR14X
• U-Y: ALA14Y, ARG22Y, CYS11U, CYS19Y, GLU13Y, GLU21Y, GLY20Y, ILE10U, LEU13U, LEU15Y, LEU16U, LEU17Y, SER12U, TYR14U, TYR16Y, VAL18Y
• U-4: ASN21U, CYS20U, GLU214, ILE2U, LYS294, PHE254, PRO284, THR274, TYR164, TYR264, VAL3U
• V-X: ALA14V, ARG22V, CYS11X, CYS19V, GLU21V, GLY20V, ILE10X, LEU13X, LEU15V, LEU16X, LEU17V, SER12X, TYR16V, VAL18V
• V-Y: ALA14V, ALA14Y, CYS19Y, GLU13V, GLU13Y, HIS10V, HIS10Y, LEU11V, LEU11Y, LEU15V, LEU15Y, LEU17V, LEU17Y, TYR16V, TYR16Y, VAL18V, VAL18Y
• V-3: ASN213, CYS203, ILE23, PHE24V, PHE25V, PRO28V, THR27V, TYR16V, TYR193, TYR26V, VAL33
• V-4: ALA144, ALA14V, ARG224, ARG22V, ASN34, CYS194, CYS19V, CYS74, CYS7V, GLN44, GLN4V, GLU134, GLU13V, GLU214, GLU21V, GLY204, GLY20V, GLY234, GLY23V, GLY84, GLY8V, HIS104, HIS10V, HIS54, HIS5V, LEU114, LEU11V, LEU154, LEU15V, LEU174, LEU17V, LEU64, LEU6V, LYS294, LYS29V, PHE244, PHE24V, PHE254, PHE25V, PRO284, PRO28V, SER94, SER9V, THR274, THR27V, TYR164, TYR16V, TYR264, TYR26V, VAL124, VAL12V, VAL18V, VAL24
• X-Y: ALA14Y, ARG22Y, ASN18X, ASN21X, ASN3Y, CYS11X, CYS19Y, CYS20X, CYS6X, CYS7X, CYS7Y, GLN15X, GLN4Y, GLN5X, GLU13Y, GLU17X, GLU21Y, GLU4X, GLY1X, GLY20Y, GLY23Y, GLY8Y, HIS10Y, HIS5Y, ILE10X, ILE2X, LEU11Y, LEU13X, LEU15Y, LEU16X, LEU17Y, LEU6Y, LYS29Y, PHE24Y, PHE25Y, PRO28Y, SER12X, SER9X, SER9Y, THR27Y, THR8X, TYR14X, TYR16Y, TYR19X, TYR26Y, VAL12Y, VAL18Y, VAL3X
• X-4: ASN34, CYS11X, CYS6X, CYS7X, GLN44, GLN5X, HIS54, ILE10X, LEU13X, LEU16X, LEU64, PHE14, SER9X, THR8X, VAL24, VAL3X
• Y-1: ASN3Y, CYS111, CYS61, CYS71, GLN4Y, GLN51, HIS5Y, ILE101, LEU131, LEU161, LEU6Y, LYS29Y, PHE1Y, SER91, THR81, VAL2Y, VAL31
• Y-2: ALA142, ASN32, ASN3Y, CYS72, CYS7Y, GLN42, GLU132, GLU13Y, GLY82, GLY8Y, HIS102, HIS10Y, HIS52, HIS5Y, LEU112, LEU11Y, LEU62, LEU6Y, PHE12, PHE1Y, SER92, SER9Y, VAL22, VAL2Y
• Y-4: ALA14Y, ASN34, ASN3Y, CYS74, CYS7Y, GLN4Y, GLU134, GLU13Y, GLY84, GLY8Y, HIS104, HIS10Y, HIS54, HIS5Y, LEU114, LEU11Y, LEU64, LEU6Y, PHE14, PHE1Y, SER94, SER9Y, VAL124, VAL24, VAL2Y
• 1-2: ALA142, ARG222, ASN181, ASN211, ASN32, CYS111, CYS192, CYS201, CYS61, CYS71, CYS72, GLN151, GLN42, GLN51, GLU132, GLU171, GLU212, GLU41, GLY11, GLY202, GLY232, GLY82, HIS102, HIS52, ILE101, ILE21, LEU112, LEU131, LEU152, LEU161, LEU172, LEU62, LYS292, PHE242, PHE252, PRO282, SER121, SER91, SER92, THR272, THR81, TYR141, TYR162, TYR191, TYR262, VAL122, VAL182, VAL31
• 2-3: ASN32, CYS113, CYS63, CYS73, GLN42, GLN53, HIS52, ILE103, LEU133, LEU163, LEU62, PHE12, SER123, SER93, THR83, VAL22, VAL33
• 2-4: ALA144, ASN32, ASN34, CYS72, CYS74, GLN44, GLU132, GLU134, GLY82, GLY84, HIS102, HIS104, HIS52, HIS54, LEU112, LEU114, LEU62, LEU64, PHE12, PHE14, SER92, SER94, VAL22, VAL24
• 3-4: ALA144, ARG224, ASN183, ASN213, ASN34, CYS113, CYS194, CYS203, CYS63, CYS73, CYS74, GLN153, GLN44, GLN53, GLU134, GLU173, GLU214, GLU43, GLY13, GLY204, GLY234, GLY84, HIS104, HIS54, ILE103, ILE23, LEU114, LEU133, LEU154, LEU163, LEU174, LEU64, LYS294, PHE244, PHE254, PRO284, SER123, SER93, SER94, THR274, THR83, TYR143, TYR164, TYR193, TYR264, VAL124, VAL184, VAL33
• 3-g: ASN183, ASN18g, CYS11g, CYS203, CYS20g, GLN153, GLN15g, GLN5g, GLU173, GLU17g, LEU133, LEU13g, LEU16g, SER123, SER12g, TYR143, TYR14g, TYR19g
• 3-h: ARG22h, TYR143, VAL18h
• 4-f: GLU214, GLU21f
• 4-g: ARG224, CYS11g, CYS194, GLN15g, GLN5g, GLY204, LEU174, SER12g, SER9g, TYR14g, VAL184
• a-b: ALA14b, ARG22b, ASN18a, ASN21a, ASN3b, CYS11a, CYS19b, CYS20a, CYS6a, CYS7a, CYS7b, GLN15a, GLN4b, GLN5a, GLU13b, GLU17a, GLU21b, GLU4a, GLY1a, GLY20b, GLY23b, GLY8b, HIS10b, HIS5b, ILE10a, ILE2a, LEU11b, LEU13a, LEU15b, LEU16a, LEU17b, LEU6b, LYS29b, PHE1b, PHE24b, PHE25b, PRO28b, SER12a, SER9a, SER9b, THR27b, THR8a, TYR14a, TYR16b, TYR19a, TYR26b, VAL12b, VAL18b, VAL3a
• a-f: ASN3f, CYS11a, CYS6a, CYS7a, GLN4f, GLN5a, HIS5f, ILE10a, LEU13a, LEU16a, LEU6f, PHE1f, SER9a, THR8a, VAL2f, VAL3a
• a-i: GLU17a, GLU17i, LEU13a, LEU13i, LEU16a, TYR14a, TYR14i
• a-j: ALA14j, ARG22j, CYS11a, CYS19j, GLU21j, GLY20j, ILE10a, LEU13a, LEU16a, LEU17j, SER12a, TYR16j, VAL18j
• a-l: ASN21a, CYS20a, ILE2a, PHE24l, PHE25l, PRO28l, THR27l, TYR16l, TYR19a, TYR26l, VAL3a
• b-c: ASN3b, CYS11c, CYS6c, CYS7c, GLN4b, GLN5c, GLU4c, HIS5b, ILE10c, LEU13c, LEU16c, LEU6b, PHE1b, SER9c, THR8c, VAL2b, VAL3c
• b-d: ALA14d, ASN3b, ASN3d, CYS7b, CYS7d, GLN4d, GLU13b, GLU13d, GLY8b, GLY8d, HIS10b, HIS10d, HIS5b, HIS5d, LEU11b, LEU11d, LEU6b, LEU6d, PHE1d, SER9b, SER9d, VAL12b, VAL2b
• b-f: ALA14b, ASN3b, ASN3f, CYS7b, CYS7f, GLN4b, GLU13b, GLU13f, GLY8b, GLY8f, HIS10b, HIS10f, HIS5b, HIS5f, LEU11b, LEU11f, LEU6b, LEU6f, PHE1b, PHE1f, SER9b, SER9f, VAL12f, VAL2b, VAL2f
• b-i: ALA14b, ARG22b, CYS11i, CYS19b, GLU13b, GLU21b, GLY20b, ILE10i, LEU13i, LEU15b, LEU16i, LEU17b, SER12i, TYR14i, TYR16b, VAL18b
• b-j: ALA14b, ALA14j, CYS19b, GLU13b, GLU13j, HIS10b, HIS10j, LEU11b, LEU11j, LEU15b, LEU15j, LEU17b, LEU17j, TYR16b, TYR16j, VAL18b, VAL18j
• b-k: ASN21k, CYS20k, LYS29b, PHE25b, PRO28b, THR27b, TYR16b, TYR26b, VAL3k
• b-l: ALA14b, ALA14l, ARG22b, ARG22l, ASN3b, ASN3l, CYS19b, CYS19l, CYS7b, CYS7l, GLN4b, GLN4l, GLU13b, GLU13l, GLU21b, GLU21l, GLY20b, GLY20l, GLY23b, GLY23l, GLY8b, GLY8l, HIS10b, HIS10l, HIS5b, HIS5l, LEU11b, LEU11l, LEU15b, LEU15l, LEU17b, LEU17l, LEU6b, LEU6l, LYS29b, PHE1b, PHE24b, PHE24l, PHE25b, PHE25l, PRO28b, PRO28l, SER9b, SER9l, THR27b, THR27l, TYR16b, TYR16l, TYR26b, TYR26l, VAL12b, VAL12l, VAL18b, VAL18l, VAL2b, VAL2l
• c-d: ALA14d, ARG22d, ASN18c, ASN21c, ASN3d, CYS11c, CYS19d, CYS20c, CYS6c, CYS7c, CYS7d, GLN15c, GLN4d, GLN5c, GLU13d, GLU17c, GLU21d, GLU4c, GLY1c, GLY20d, GLY23d, GLY8d, HIS10d, HIS5d, ILE10c, ILE2c, LEU11d, LEU13c, LEU15d, LEU16c, LEU17d, LEU6d, LYS29d, PHE24d, PHE25d, PRO28d, SER12c, SER9c, SER9d, THR27d, THR8c, TYR14c, TYR16d, TYR19c, TYR26d, VAL12d, VAL18d, VAL3c
• c-h: ASN21c, CYS20c, CYS7c, ILE2c, LYS29h, PHE25h, PRO28h, THR27h, TYR16h, TYR26h, VAL3c
• c-k: GLU17c, GLU17k, LEU13c, LEU13k, LEU16c, TYR14k
• c-l: ALA14l, ARG22l, CYS11c, CYS19l, GLU21l, GLY20l, ILE10c, LEU13c, LEU16c, LEU17l, SER12c, TYR16l, VAL18l
• d-e: ASN3d, CYS11e, CYS6e, CYS7e, GLN4d, GLN5e, HIS5d, ILE10e, LEU13e, LEU16e, LEU6d, PHE1d, SER12e, SER9e, THR8e, VAL2d, VAL3e
• d-f: ALA14f, ASN3d, ASN3f, CYS7d, CYS7f, GLN4f, GLU13d, GLU13f, GLY8d, GLY8f, HIS10d, HIS10f, HIS5d, HIS5f, LEU11d, LEU11f, LEU6d, LEU6f, PHE1d, PHE1f, SER9d, SER9f, VAL2d, VAL2f
• d-g: ASN21g, CYS20g, CYS7g, GLU21d, ILE2g, PHE24d, PHE25d, PRO28d, THR27d, TYR16d, TYR19g, TYR26d, VAL3g
• d-h: ALA14d, ALA14h, ARG22d, ARG22h, ASN3d, ASN3h, CYS19d, CYS19h, CYS7d, CYS7h, GLN4d, GLN4h, GLU13d, GLU13h, GLU21d, GLU21h, GLY20d, GLY20h, GLY23d, GLY23h, GLY8d, GLY8h, HIS10d, HIS10h, HIS5d, HIS5h, LEU11d, LEU11h, LEU15d, LEU15h, LEU17d, LEU17h, LEU6d, LEU6h, LYS29d, LYS29h, PHE24d, PHE24h, PHE25d, PHE25h, PRO28d, PRO28h, SER9d, SER9h, THR27d, THR27h, TYR16d, TYR16h, TYR26d, TYR26h, VAL12d, VAL12h, VAL18d, VAL18h, VAL2h
• d-k: ALA14d, ARG22d, CYS11k, CYS19d, GLU13d, GLU21d, GLY20d, ILE10k, LEU13k, LEU15d, LEU16k, LEU17d, SER12k, TYR16d, VAL18d
• d-l: ALA14d, ALA14l, CYS19d, GLU13d, GLU13l, HIS10d, HIS10l, LEU11d, LEU11l, LEU15d, LEU15l, LEU17d, LEU17l, TYR16d, TYR16l, VAL12l, VAL18d, VAL18l
• e-f: ALA14f, ARG22f, ASN18e, ASN21e, ASN3f, CYS11e, CYS19f, CYS20e, CYS6e, CYS7e, CYS7f, GLN15e, GLN4f, GLN5e, GLU13f, GLU17e, GLU21f, GLU4e, GLY1e, GLY20f, GLY23f, GLY8f, HIS10f, HIS5f, ILE10e, ILE2e, LEU11f, LEU13e, LEU15f, LEU16e, LEU17f, LEU6f, LYS29f, PHE24f, PHE25f, PRO28f, SER12e, SER9e, SER9f, THR27f, THR8e, TYR14e, TYR16f, TYR19e, TYR26f, VAL12f, VAL18f, VAL3e
• e-g: GLU17e, GLU17g, LEU13e, LEU13g, LEU16g, TYR14e, TYR14g
• e-h: ALA14h, ARG22h, CYS11e, CYS19h, GLU13h, GLU21h, GLY20h, ILE10e, LEU13e, LEU15h, LEU16e, LEU17h, SER12e, TYR14e, TYR16h, VAL18h
• e-j: ASN21e, CYS20e, ILE2e, LYS29j, PHE24j, PHE25j, PRO28j, THR27j, TYR16j, TYR19e, TYR26j, VAL3e
• f-g: ALA14f, ARG22f, CYS11g, CYS19f, GLU21f, GLY20f, ILE10g, LEU13g, LEU15f, LEU16g, LEU17f, SER12g, TYR16f, VAL18f
• f-h: ALA14f, ALA14h, CYS19h, GLU13f, GLU13h, HIS10f, HIS10h, LEU11f, LEU11h, LEU15f, LEU15h, LEU17f, LEU17h, TYR16f, TYR16h, VAL12f, VAL18f, VAL18h
• f-i: ASN21i, CYS20i, GLU21f, ILE2i, PHE24f, PHE25f, PRO28f, THR27f, TYR16f, TYR26f, VAL3i
• f-j: ALA14f, ALA14j, ARG22f, ARG22j, ASN3f, ASN3j, CYS19f, CYS19j, CYS7f, CYS7j, GLN4f, GLN4j, GLU13f, GLU13j, GLU21f, GLU21j, GLY20f, GLY20j, GLY23f, GLY23j, GLY8f, GLY8j, HIS10f, HIS10j, HIS5f, HIS5j, LEU11f, LEU11j, LEU15f, LEU15j, LEU17f, LEU17j, LEU6f, LEU6j, LYS29f, LYS29j, PHE24f, PHE24j, PHE25f, PHE25j, PRO28f, PRO28j, SER9f, SER9j, THR27f, THR27j, TYR16f, TYR16j, TYR26f, TYR26j, VAL12f, VAL12j, VAL18f, VAL18j, VAL2f, VAL2j
• g-h: ALA14h, ARG22h, ASN18g, ASN21g, ASN3h, CYS11g, CYS19h, CYS20g, CYS6g, CYS7g, CYS7h, GLN15g, GLN4h, GLN5g, GLU13h, GLU17g, GLU21h, GLU4g, GLY1g, GLY20h, GLY23h, GLY8h, HIS10h, HIS5h, ILE10g, ILE2g, LEU11h, LEU13g, LEU15h, LEU16g, LEU17h, LEU6h, LYS29h, PHE24h, PHE25h, PRO28h, SER12g, SER9g, SER9h, THR27h, THR8g, TYR14g, TYR16h, TYR19g, TYR26h, VAL12h, VAL18h, VAL3g
• g-j: ASN3j, CYS11g, CYS6g, CYS7g, GLN4j, GLN5g, GLU4g, HIS5j, ILE10g, LEU13g, LEU16g, LEU6j, PHE1j, SER9g, THR8g, VAL2j, VAL3g
• h-j: ALA14h, ASN3h, ASN3j, CYS7h, CYS7j, GLN4h, GLU13h, GLU13j, GLY8h, GLY8j, HIS10h, HIS10j, HIS5h, HIS5j, LEU11h, LEU11j, LEU6h, LEU6j, PHE1h, PHE1j, SER9h, SER9j, VAL12j, VAL2h, VAL2j
• h-k: ASN3h, CYS11k, CYS6k, CYS7k, GLN4h, GLN5k, HIS5h, ILE10k, LEU13k, LEU16k, LEU6h, LYS29h, PHE1h, SER12k, SER9k, THR8k, VAL2h, VAL3k
• h-l: ALA14l, ASN3h, ASN3l, CYS7h, CYS7l, GLN4l, GLU13h, GLU13l, GLY8h, GLY8l, HIS10h, HIS10l, HIS5h, HIS5l, LEU11h, LEU11l, LEU6h, LEU6l, PHE1h, PHE1l, SER9h, SER9l, VAL2h, VAL2l
• i-j: ALA14j, ARG22j, ASN18i, ASN21i, ASN3j, CYS11i, CYS19j, CYS20i, CYS6i, CYS7i, CYS7j, GLN15i, GLN4j, GLN5i, GLU13j, GLU17i, GLU21j, GLU4i, GLY1i, GLY20j, GLY23j, GLY8j, HIS10j, HIS5j, ILE10i, ILE2i, LEU11j, LEU13i, LEU15j, LEU16i, LEU17j, LEU6j, LYS29j, PHE24j, PHE25j, PRO28j, SER12i, SER9i, SER9j, THR27j, THR8i, TYR14i, TYR16j, TYR19i, TYR26j, VAL12j, VAL18j, VAL3i
• i-l: ASN3l, CYS11i, CYS6i, CYS7i, GLN4l, GLN5i, HIS5l, ILE10i, LEU13i, LEU16i, LEU6l, PHE1l, SER12i, SER9i, THR8i, VAL2l, VAL3i
• j-l: ALA14j, ASN3j, ASN3l, CYS7j, CYS7l, GLN4j, GLU13j, GLU13l, GLY8j, GLY8l, HIS10j, HIS10l, HIS5j, HIS5l, LEU11j, LEU11l, LEU6j, LEU6l, PHE1j, PHE1l, SER9j, SER9l, VAL2j, VAL2l
• k-l: ALA14l, ARG22l, ASN18k, ASN21k, ASN3l, CYS11k, CYS19l, CYS20k, CYS6k, CYS7k, CYS7l, GLN15k, GLN4l, GLN5k, GLU13l, GLU17k, GLU21l, GLU4k, GLY1k, GLY20l, GLY23l, GLY8l, HIS10l, HIS5l, ILE10k, ILE2k, LEU11l, LEU13k, LEU15l, LEU16k, LEU17l, LEU6l, PHE24l, PHE25l, PRO28l, SER12k, SER9k, SER9l, THR27l, THR8k, TYR14k, TYR16l, TYR19k, TYR26l, VAL12l, VAL18l, VAL3k