2OM0
structure of human insulin in presence of urea at ph 6.5
Total interactions analyzed 630
Total true interactions 139
Strongest Interaction Chains d-h
Int. Res. 55
Norm. En. per Res. -5.2785
Hub Node B(14)
Click on the Nodes or Edges in the network to see the details
Weak Strong
Width of edge <-> No. of inter. res.
All Interactions
Download
Chains Hydro. Bond Ener. (kJ/mol) Elec. Ener. (kJ/mol) VDW. Ener. (kJ/mol) Tot. Stab. Ener. (kJ/mol) #int. res. # Short cont. #Hydr. int. #VDW pairs #salt bridges #Pot. fav. elec. int #Pot. unfav. elec. int int. res.
A-B -25.0848 -32.0991 526.536 469.3522 48 19 8 6163 2 2 2
A-D 0.0 0.0 -8.6003 -8.6003 11 4 0 330 0 0 1
A-F 0.0 0.0 -23.1085 -23.1085 17 9 2 1604 0 0 0
A-G 0.0 0.0 -2.9037 -2.9037 7 0 1 215 0 0 1
A-H 0.0 0.0 -8.8505 -8.8505 14 0 2 483 0 0 0
B-C 0.0 0.0 -9.5699 -9.5699 13 0 0 342 0 0 1
B-D -65.927 2.8291 -231.198 -294.2959 57 8 7 7161 0 7 5
B-F 0.0 12.1858 -29.7512 -17.5654 22 1 1 1278 0 3 3
B-G 0.0 0.0 -6.9852 -6.9852 13 0 0 460 0 0 0
B-H 0.0 17.3637 -21.6907 -4.327 16 0 3 1091 0 2 2
B-I -5.564 0.0 -43.3984 -48.9624 17 2 1 1672 0 0 0
B-J 0.0 11.759 -40.4171 -28.6581 24 4 1 1789 0 3 3
C-D -20.6487 -32.5772 1351.79 1298.5641 49 18 8 5882 2 3 2
C-I 0.0 0.0 -1.6997 -1.6997 7 0 0 174 0 0 0
C-J 0.0 0.0 -11.7189 -11.7189 14 1 0 573 0 0 0
C-L 0.0 0.0 -39.1878 -39.1878 16 0 1 1436 0 0 0
C-U -2.8755 0.0 -54.1761 -57.0516 19 2 0 1275 0 0 2
C-V 0.0 0.0 -4.7149 -4.7149 11 0 0 314 0 0 0
C-X 0.0 43.2147 -42.1324 1.0823 14 1 3 1486 0 0 1
C-Y 0.0 0.0 -3.0408 -3.0408 6 0 0 239 0 1 1
D-G -8.0798 0.0 -46.3436 -54.4234 17 0 1 1541 0 0 0
D-H 0.0 11.4396 -26.2682 -14.8286 23 1 1 1125 0 3 4
D-I 0.0 0.0 -10.6733 -10.6733 16 0 2 529 0 0 0
D-J 0.0 19.9931 2.432 22.425 17 3 3 1075 0 2 2
D-L 0.0 11.7508 -25.3594 -13.6085 23 1 1 1106 0 3 4
D-U 0.0 0.0 -0.0275 -0.0275 2 0 0 11 0 0 0
D-X 0.0 0.0 -6.1269 -6.1269 7 0 0 258 0 1 1
D-Y 0.0 0.0 -0.2446 -0.2446 2 0 0 44 0 2 1
E-F -22.9257 -29.632 1275.44 1222.8822 49 14 8 6180 2 3 2
E-H 0.0 0.0 -8.0617 -8.0617 12 0 0 299 0 0 1
E-J 0.0 0.0 -39.8762 -39.8762 16 0 2 1463 0 0 0
E-K 0.0 0.0 -2.238 -2.238 7 0 0 207 0 0 0
E-L 0.0 0.0 -11.7266 -11.7266 14 2 1 570 0 0 0
F-G 0.0 0.0 7.8507 7.8507 10 3 0 255 0 0 1
F-H -49.4645 -0.5586 -230.937 -280.9601 57 6 8 7111 0 8 6
F-J 0.0 11.3107 -26.1015 -14.7909 22 1 1 1143 0 3 3
F-K 0.0 0.0 -9.9314 -9.9314 16 0 2 549 0 0 0
F-L 0.0 -4.3003 -19.4663 -23.7666 18 0 3 1113 0 2 2
G-H -10.0299 -24.3526 1441.0 1406.6175 48 11 7 5954 2 3 2
H-K -7.5439 0.0 -44.8704 -52.4143 17 1 1 1566 0 0 0
H-L 0.0 12.1115 -47.6595 -35.548 23 2 1 1685 0 3 3
I-J -15.0107 -34.5072 1381.15 1331.6321 49 16 9 6527 2 3 2
I-L 0.0 0.0 -7.8578 -7.8578 11 2 0 327 0 0 1
I-X -13.8236 0.0 -54.1127 -67.9363 18 1 0 1284 0 0 2
I-Y 0.0 0.0 -0.0227 -0.0227 2 0 0 8 0 0 0
J-K 0.0 0.0 0.4721 0.4721 12 10 0 359 0 0 1
J-L -48.5514 5.136 -196.287 -239.7025 56 10 6 6530 0 8 6
J-V 0.0 0.0 -0.0657 -0.0657 2 0 0 6 0 0 1
J-X 0.0 0.0 -3.9691 -3.9691 11 1 0 268 0 0 0
K-L -12.6777 -31.1361 1289.31 1245.4962 48 19 9 6529 3 3 2
Q-R -15.9848 -37.5159 485.2 431.6993 49 13 8 6299 2 3 2
Q-T 0.0 0.0 -40.9286 -40.9286 17 0 1 1462 0 0 0
Q-Y 0.0 0.0 -6.2277 -6.2277 9 1 0 242 0 0 1
Q-1 0.0 0.0 -1.7029 -1.7029 7 0 0 189 0 0 0
Q-2 0.0 0.0 -10.9137 -10.9137 16 0 2 565 0 0 0
R-T 0.0 11.5945 -49.2858 -37.6913 23 1 1 1784 0 3 3
R-U 0.0 0.0 -39.7423 -39.7423 17 1 1 1463 0 0 0
R-V 0.0 11.1532 -28.317 -17.1638 22 2 1 1208 0 3 3
R-X 0.0 0.0 -7.1388 -7.1388 12 3 0 330 0 0 1
R-Y -64.5708 -1.2468 -210.918 -276.7356 55 9 7 6807 0 8 6
R-1 0.0 0.0 -10.9109 -10.9109 14 0 0 572 0 0 0
R-2 0.0 12.0633 -22.643 -10.5797 19 0 3 1094 0 2 2
S-T -19.9503 -29.9584 1367.13 1317.2213 48 16 8 6162 2 3 2
S-V -2.1449 0.0 -37.2386 -39.3835 15 0 1 1351 0 0 0
S-2 0.0 0.0 -8.8233 -8.8233 13 2 0 324 0 0 1
S-3 0.0 0.0 -1.7988 -1.7988 7 0 0 172 0 0 0
S-4 0.0 0.0 -10.948 -10.948 13 0 0 558 0 0 0
S-e -9.4467 0.0 -56.8012 -66.2479 19 1 0 1309 0 0 2
S-f 0.0 0.0 -6.078 -6.078 11 1 0 361 0 1 0
S-g 0.0 44.2568 -38.6612 5.5956 14 1 3 1550 0 0 1
S-h 0.0 0.0 -4.1339 -4.1339 7 0 0 255 0 1 1
T-V 0.0 11.855 -36.3959 -24.5409 24 1 1 1501 0 3 4
T-1 0.0 0.0 -5.0612 -5.0612 13 3 0 327 0 0 1
T-2 -55.6592 4.3406 -212.102 -263.4206 55 13 7 7149 0 8 6
T-3 0.0 0.0 -9.7522 -9.7522 16 0 2 521 0 0 0
T-4 0.0 -6.7395 -19.5002 -26.2397 18 0 3 1109 0 2 2
T-e 0.0 0.0 -0.0357 -0.0357 3 0 0 17 0 0 0
T-g 0.0 0.0 -3.6535 -3.6535 7 0 0 250 0 1 1
T-h 0.0 0.0 -0.1552 -0.1552 2 0 0 35 0 0 1
U-V -20.6233 -34.8445 1315.32 1259.8522 48 12 8 6245 2 3 2
U-X 0.0 0.0 -2.0185 -2.0185 7 0 0 187 0 0 0
U-Y 0.0 0.0 -10.2094 -10.2094 16 0 2 529 0 0 0
U-4 0.0 0.0 -5.0396 -5.0396 10 0 0 210 0 0 1
V-X 0.0 0.0 -10.6271 -10.6271 13 1 0 548 0 0 0
V-Y 0.0 21.2636 -22.7045 -1.4409 17 0 3 1105 0 2 2
V-3 0.0 0.0 -8.2799 -8.2799 11 1 0 289 0 0 1
V-4 -48.5438 1.5192 -222.219 -269.2436 56 8 6 6865 1 8 6
X-Y -13.5228 -29.0903 1152.44 1109.8269 48 23 8 6158 2 3 2
X-4 -4.7244 0.0 -43.4828 -48.2072 16 1 1 1509 0 0 0
Y-1 -4.8635 0.0 -40.9816 -45.8451 16 1 1 1497 0 0 0
Y-2 0.0 11.7008 -41.2903 -29.5895 24 4 1 1671 0 3 3
Y-4 0.0 11.0492 -44.1417 -33.0925 24 3 1 1694 0 3 3
1-2 -23.554 -33.9345 1156.55 1099.0615 48 10 8 6124 2 3 2
2-3 -5.4328 0.0 -48.6744 -54.1072 17 2 1 1645 0 0 0
2-4 0.0 12.07 -43.6851 -31.6151 24 3 1 1773 0 3 3
3-4 -11.4993 -35.783 1449.44 1402.1577 48 13 9 6517 2 3 2
3-g 0.0 0.0 -53.3054 -53.3054 19 1 0 1239 0 0 2
3-h 0.0 0.0 -0.0361 -0.0361 3 0 0 16 0 0 0
4-f 0.0 0.0 -0.0071 -0.0071 2 0 0 1 0 0 1
4-g 0.0 0.0 -5.8111 -5.8111 11 1 0 339 0 0 0
a-b -20.6592 -29.0853 -135.75 -185.4945 49 16 8 6139 2 3 2
a-f -4.9117 0.0 -42.5557 -47.4674 16 1 1 1555 0 0 0
a-i 0.0 0.0 -1.606 -1.606 7 0 0 176 0 0 0
a-j 0.0 0.0 -10.5986 -10.5986 13 1 0 530 0 0 0
a-l 0.0 0.0 -8.6831 -8.6831 12 2 0 339 0 0 1
b-c 0.0 0.0 -32.8168 -32.8168 17 0 1 1284 0 0 0
b-d 0.0 12.2874 -26.8263 -14.5389 23 2 1 1177 0 3 3
b-f 0.0 10.9996 -41.8748 -30.8752 24 2 1 1641 0 3 3
b-i 0.0 0.0 -9.7139 -9.7139 16 0 2 532 0 0 0
b-j 0.0 20.1755 -25.016 -4.8406 18 0 3 1123 0 2 2
b-k 0.0 0.0 -4.0499 -4.0499 10 0 0 189 0 0 1
b-l -45.0551 -12.2038 -227.224 -284.4829 58 5 7 7248 0 8 6
c-d -11.4025 -28.4673 1123.69 1083.8202 48 17 8 5768 2 3 2
c-h 0.0 0.0 -7.6581 -7.6581 12 0 0 260 0 0 1
c-k 0.0 0.0 -2.7182 -2.7182 6 0 1 204 0 0 1
c-l 0.0 0.0 -9.7161 -9.7161 13 1 0 545 0 0 0
d-e -4.5315 0.0 -45.9974 -50.5289 17 1 1 1554 0 0 0
d-f 0.0 11.7143 -37.4405 -25.7262 24 3 1 1708 0 3 3
d-g 0.0 0.0 -9.6055 -9.6055 12 0 0 302 0 0 1
d-h -60.0747 -4.4646 -225.778 -290.3173 55 12 6 7258 0 8 6
d-k 0.0 0.0 -10.139 -10.139 15 0 2 532 0 0 0
d-l 0.0 19.9576 -25.5497 -5.5921 18 0 3 1135 0 2 2
e-f -19.5905 -32.5524 1192.92 1140.7771 48 10 9 6524 2 3 2
e-g 0.0 0.0 -1.9248 -1.9248 7 0 0 175 0 0 0
e-h 0.0 0.0 -9.8391 -9.8391 16 0 2 538 0 0 0
e-j 0.0 0.0 -8.5339 -8.5339 12 0 0 323 0 0 1
f-g 0.0 0.0 -10.4136 -10.4136 14 0 0 525 0 0 0
f-h 0.0 12.2907 -23.4729 -11.1822 19 1 3 1126 0 2 2
f-i 0.0 0.0 -8.1684 -8.1684 10 4 0 335 0 0 1
f-j -56.2998 -1.791 -211.383 -269.4738 55 8 6 6898 1 8 6
g-h -25.8031 -29.2672 1165.45 1110.3796 48 18 8 6238 2 3 2
g-j 0.0 0.0 -32.2741 -32.2741 16 2 1 1277 0 0 0
h-j 0.0 11.6704 -26.8638 -15.1934 24 3 1 1271 0 3 4
h-k 0.0 0.0 -40.7488 -40.7488 18 0 1 1483 0 0 0
h-l 0.0 11.5972 -46.9142 -35.317 23 1 1 1708 0 3 3
i-j -9.7733 -31.034 1465.81 1425.0027 49 18 9 6770 1 3 2
i-l 0.0 0.0 -46.5791 -46.5791 18 1 2 1689 0 0 0
j-l 0.0 11.6241 -27.2833 -15.6592 22 1 1 1205 0 3 3
k-l -9.3314 -20.2932 1301.55 1271.9254 48 11 8 5882 0 3 2