2O7E

tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant), bound to 2-aminoindan-2-phosphonic acid

• Total interactions analyzed: 28
• Total true interactions: 18
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 379
  • Norm. En. per Res.: -5.0339
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-132.6483	-80.4568	-844.672	-1057.7771	277	30	32	35476	18	50	45
A-C	0.0	7.8881	-21.053	-13.1649	46	1	0	1561	0	10	15
A-D	-324.1487	-155.2621	-1428.45	-1907.8608	379	66	50	55132	15	94	93
A-H	0.0	12.3175	-0.413	11.9045	4	0	0	38	0	0	1
B-C	-322.8379	-143.7221	-1407.1	-1873.6601	378	68	50	54891	12	95	93
B-D	0.0	8.8796	-24.0178	-15.1381	50	2	0	1653	0	10	15
B-F	-4.2015	-12.8137	-62.9909	-80.006	54	0	2	2444	0	26	23
B-G	0.0	14.5751	-0.5046	14.0705	5	0	0	35	0	0	1
C-D	-132.5891	-80.2335	-844.35	-1057.1726	278	36	31	35552	15	52	44
C-F	0.0	15.9245	-0.7603	15.1641	5	0	0	51	0	0	1
D-E	0.0	13.3116	-0.4779	12.8337	5	0	0	41	0	0	1
D-H	-5.4824	-13.0865	-61.2087	-79.7776	47	0	2	2333	0	26	20
E-F	-130.328	-80.5107	-847.249	-1058.0877	278	35	33	35506	17	51	45
E-G	0.0	8.2322	-21.3915	-13.1593	50	1	0	1592	0	10	15
E-H	-320.2719	-149.2092	-1410.31	-1879.7911	381	58	49	54716	12	95	93
F-G	-328.5617	-156.1387	-1416.98	-1901.6803	379	68	50	54961	14	94	93
F-H	0.0	7.9572	-16.187	-8.2298	46	6	0	1670	0	10	15
G-H	-123.5681	-80.9793	-845.097	-1049.6444	278	33	32	35552	17	52	43

Interface residues

• A-B: ALA157A, ALA157B, ALA378A, ALA378B, ALA398A, ALA398B, ALA407A, ALA407B, ALA411A, ALA411B, ALA413A, ALA413B, ALA416A, ALA416B, ALA420A, ALA420B, ALA424A, ALA424B, ALA433A, ALA433B, ALA434A, ALA434B, ALA445A, ALA445B, ALA461A, ALA461B, ALA511A, ALA511B, ALA512A, ALA512B, ALA514A, ALA514B, ALA70A, ALA70B, ALA84A, ALA84B, ALA91A, ALA91B, ARG144A, ARG144B, ARG166A, ARG166B, ARG176A, ARG176B, ARG375A, ARG375B, ARG379A, ARG379B, ARG384A, ARG384B, ARG395A, ARG395B, ARG419A, ARG419B, ARG447A, ARG447B, ARG455A, ARG455B, ARG504A, ARG504B, ARG72A, ARG72B, ARG80A, ARG80B, ASN386A, ASN386B, ASN401A, ASN401B, ASN432A, ASN432B, ASN435A, ASN435B, ASN71A, ASN71B, ASN78A, ASN78B, ASN85A, ASN85B, ASP168A, ASP168B, ASP360A, ASP360B, ASP382A, ASP382B, ASP454A, ASP454B, ASP503A, ASP503B, GLN408A, GLN408B, GLN436A, GLN436B, GLN508A, GLN508B, GLN83A, GLN83B, GLU374A, GLU374B, GLU383A, GLU383B, GLU417A, GLU417B, GLU451A, GLU451B, GLU458A, GLU458B, GLU509A, GLU509B, GLU77A, GLU77B, GLY145A, GLY145B, GLY148A, GLY148B, GLY167A, GLY167B, GLY371A, GLY371B, GLY396A, GLY396B, GLY399A, GLY399B, GLY403A, GLY403B, GLY406A, GLY406B, GLY422A, GLY422B, GLY507A, GLY507B, GLY65A, GLY65B, GLY67A, GLY67B, GLY93A, GLY93B, GLY95A, GLY95B, HIS158A, HIS158B, HIS394A, HIS394B, HIS427A, HIS427B, HIS88A, HIS88B, ILE377A, ILE377B, ILE426A, ILE426B, ILE429A, ILE429B, ILE444A, ILE444B, ILE459A, ILE459B, ILE462A, ILE462B, ILE510A, ILE510B, ILE74A, ILE74B, LEU153A, LEU153B, LEU161A, LEU161B, LEU385A, LEU385B, LEU389A, LEU389B, LEU393A, LEU393B, LEU400A, LEU400B, LEU414A, LEU414B, LEU415A, LEU415B, LEU441A, LEU441B, LEU448A, LEU448B, LEU500A, LEU500B, LEU506A, LEU506B, LEU69A, LEU69B, LEU73A, LEU73B, LEU82A, LEU82B, LEU86A, LEU86B, LEU90A, LEU90B, LYS452A, LYS452B, MET405A, MET405B, MET418A, MET418B, PHE392A, PHE392B, PHE404A, PHE404B, PHE66A, PHE66B, PHE89A, PHE89B, PRO142A, PRO142B, PRO155B, PRO390A, PRO390B, PRO391A, PRO391B, PRO397A, PRO397B, PRO423A, PRO423B, PRO505A, PRO505B, PRO68A, PRO68B, PRO96A, PRO96B, SER143A, SER143B, SER402A, SER402B, SER425A, SER425B, SER428A, SER428B, SER430A, SER430B, SER75A, SER75B, SER92A, SER92B, THR146A, THR146B, THR154A, THR154B, THR381A, THR381B, THR410A, THR410B, THR412A, THR412B, THR421A, THR421B, THR431A, THR431B, THR443A, THR443B, THR502A, THR502B, THR64A, THR64B, THR81A, THR81B, TYR60A, TYR60B, VAL147A, VAL147B, VAL409A, VAL409B, VAL439A, VAL439B, VAL79A, VAL79B, VAL87A, VAL87B, VAL94A, VAL94B
• A-C: ALA295A, ALA295C, ALA299A, ALA299C, ALA398A, ALA398C, ALA416A, ALA416C, ALA434A, ALA434C, ARG375A, ARG375C, ARG379A, ARG379C, ARG384A, ARG384C, ARG387A, ARG387C, ARG419A, ARG419C, ASP382A, ASP382C, GLU294A, GLU294C, GLU383A, GLU383C, GLY399A, HIS427A, HIS427C, ILE426A, ILE426C, ILE429A, ILE429C, LEU385A, LEU385C, PRO293A, PRO293C, PRO391A, PRO423A, PRO423C, SER428A, SER428C, SER430A, SER430C, THR291A, THR291C
• A-D: ALA118A, ALA118D, ALA243A, ALA243D, ALA245A, ALA245D, ALA246A, ALA246D, ALA247A, ALA247D, ALA260A, ALA260D, ALA280A, ALA280D, ALA286A, ALA286D, ALA295A, ALA295D, ALA299A, ALA299D, ALA305A, ALA305D, ALA311A, ALA311D, ALA317A, ALA317D, ALA329A, ALA329D, ALA344A, ALA344D, ALA356A, ALA356D, ALA361A, ALA361D, ALA363A, ALA363D, ALA365A, ALA365D, ALA373A, ALA373D, ALA378A, ALA378D, ALA416A, ALA416D, ALA420A, ALA420D, ALA424A, ALA424D, ALA433A, ALA433D, ALA434A, ALA434D, ALA445A, ALA445D, ALA51A, ALA51D, ALA56A, ALA56D, ALA70A, ALA70D, ARG15A, ARG240A, ARG240D, ARG252A, ARG252D, ARG282A, ARG282D, ARG283A, ARG283D, ARG303A, ARG303D, ARG321A, ARG321D, ARG375A, ARG375D, ARG379A, ARG379D, ARG419A, ARG419D, ARG54A, ARG54D, ARG57A, ARG57D, ARG72A, ARG72D, ASN203A, ASN203D, ASN328A, ASN328D, ASN333A, ASN333D, ASN349A, ASN349D, ASN432A, ASN432D, ASN435A, ASN435D, ASN71A, ASN71D, ASN78A, ASN78D, ASP250A, ASP250D, ASP285A, ASP285D, ASP288A, ASP288D, ASP298A, ASP298D, ASP314A, ASP314D, ASP332A, ASP332D, ASP339A, ASP339D, ASP360A, ASP360D, ASP382A, ASP382D, ASP437A, ASP437D, CYS304A, CYS304D, GLN116A, GLN116D, GLN257A, GLN257D, GLN297A, GLN297D, GLN307A, GLN307D, GLN353A, GLN353D, GLN376A, GLN376D, GLN436A, GLN436D, GLU242A, GLU242D, GLU281A, GLU281D, GLU292A, GLU292D, GLU294A, GLU294D, GLU326A, GLU326D, GLU374A, GLU374D, GLU55A, GLU55D, GLU77A, GLU77D, GLY117A, GLY117D, GLY148A, GLY148D, GLY256A, GLY256D, GLY287A, GLY287D, GLY290A, GLY290D, GLY296A, GLY296D, GLY310A, GLY310D, GLY312A, GLY312D, GLY340A, GLY347A, GLY347D, GLY348A, GLY348D, GLY352A, GLY352D, GLY371A, GLY371D, GLY422A, GLY422D, GLY61A, GLY61D, GLY65A, GLY65D, GLY67A, GLY67D, GLY76A, GLY76D, HIS254A, HIS254D, HIS277D, HIS319A, HIS319D, HIS346A, HIS346D, HIS354A, HIS354D, HIS427A, HIS427D, HIS58A, HIS58D, ILE279A, ILE279D, ILE289A, ILE289D, ILE325A, ILE325D, ILE426A, ILE426D, ILE429A, ILE429D, ILE74A, ILE74D, LEU153A, LEU153D, LEU199A, LEU199D, LEU233A, LEU233D, LEU248A, LEU248D, LEU251A, LEU251D, LEU284A, LEU284D, LEU302A, LEU302D, LEU309A, LEU309D, LEU316A, LEU316D, LEU323A, LEU323D, LEU327A, LEU327D, LEU345A, LEU345D, LEU357A, LEU357D, LEU362A, LEU362D, LEU369A, LEU369D, LEU372A, LEU372D, LEU385A, LEU385D, LEU415A, LEU415D, LEU441A, LEU441D, LEU62A, LEU62D, LEU69A, LEU69D, LEU73A, LEU73D, LYS258A, LYS258D, LYS452A, LYS452D, MET208A, MET208D, MET351A, MET351D, MET418A, MET418D, PHE313A, PHE313D, PHE336A, PHE336D, PHE350A, PHE350D, PHE66A, PHE66D, PRO253A, PRO253D, PRO255A, PRO255D, PRO293A, PRO293D, PRO306A, PRO306D, PRO334A, PRO334D, PRO337A, PRO337D, PRO338A, PRO338D, PRO343A, PRO343D, PRO423A, PRO423D, PRO68A, PRO68D, SER113A, SER113D, SER119A, SER119D, SER249A, SER249D, SER301A, SER301D, SER341A, SER341D, SER425A, SER425D, SER428A, SER428D, SER430A, SER430D, SER440A, SER440D, SER75A, SER75D, THR205A, THR205D, THR209A, THR209D, THR241A, THR241D, THR291A, THR291D, THR315A, THR315D, THR324A, THR324D, THR331A, THR331D, THR358A, THR358D, THR364A, THR364D, THR367A, THR367D, THR421A, THR421D, THR431A, THR431D, THR63A, THR63D, THR64A, THR64D, TRP244A, TRP244D, TRP318A, TRP318D, TYR300A, TYR300D, TYR60A, TYR60D, VAL147A, VAL147D, VAL278A, VAL278D, VAL308A, VAL308D, VAL322A, VAL322D, VAL330A, VAL330D, VAL335A, VAL335D, VAL342A, VAL342D, VAL355A, VAL355D, VAL366A, VAL366D, VAL368A, VAL368D, VAL438A, VAL438D, VAL439A, VAL439D, VAL52A, VAL52D, VAL59A, VAL59D
• A-H: ARG273H, ASP480H, GLU77A, SER75A
• B-C: ALA118B, ALA118C, ALA243B, ALA243C, ALA245B, ALA245C, ALA246B, ALA246C, ALA247B, ALA247C, ALA260B, ALA260C, ALA280B, ALA280C, ALA286B, ALA286C, ALA295B, ALA295C, ALA299B, ALA299C, ALA305B, ALA305C, ALA311B, ALA311C, ALA317B, ALA317C, ALA329B, ALA329C, ALA344B, ALA344C, ALA356B, ALA356C, ALA361B, ALA361C, ALA363B, ALA363C, ALA365B, ALA365C, ALA373B, ALA373C, ALA378B, ALA378C, ALA416B, ALA416C, ALA420B, ALA420C, ALA424B, ALA424C, ALA433B, ALA433C, ALA434B, ALA434C, ALA445B, ALA445C, ALA51B, ALA51C, ALA56B, ALA56C, ALA70B, ALA70C, ARG15B, ARG15C, ARG240B, ARG240C, ARG252B, ARG252C, ARG282B, ARG282C, ARG283B, ARG283C, ARG303B, ARG303C, ARG321B, ARG321C, ARG375B, ARG375C, ARG379B, ARG379C, ARG419B, ARG419C, ARG54B, ARG54C, ARG57B, ARG57C, ARG72B, ARG72C, ASN203B, ASN203C, ASN328B, ASN328C, ASN333B, ASN333C, ASN349B, ASN349C, ASN432B, ASN432C, ASN435B, ASN435C, ASN71B, ASN71C, ASN78B, ASN78C, ASP250B, ASP250C, ASP285B, ASP285C, ASP288B, ASP288C, ASP298B, ASP298C, ASP314B, ASP314C, ASP332B, ASP332C, ASP339B, ASP339C, ASP360B, ASP360C, ASP382B, ASP382C, ASP437B, ASP437C, CYS304B, CYS304C, GLN116B, GLN116C, GLN257B, GLN257C, GLN297B, GLN297C, GLN307B, GLN307C, GLN353B, GLN353C, GLN376B, GLN376C, GLN436B, GLN436C, GLU242B, GLU242C, GLU281B, GLU281C, GLU292B, GLU292C, GLU294B, GLU294C, GLU326B, GLU326C, GLU374B, GLU374C, GLU55B, GLU55C, GLU77B, GLU77C, GLY117B, GLY117C, GLY148B, GLY148C, GLY256B, GLY256C, GLY287B, GLY287C, GLY290B, GLY290C, GLY296B, GLY296C, GLY310B, GLY310C, GLY312B, GLY312C, GLY347B, GLY347C, GLY348B, GLY348C, GLY352B, GLY352C, GLY371B, GLY371C, GLY422B, GLY422C, GLY61B, GLY61C, GLY65B, GLY65C, GLY67B, GLY67C, GLY76B, GLY76C, HIS254B, HIS254C, HIS319B, HIS319C, HIS346B, HIS346C, HIS354B, HIS354C, HIS427B, HIS427C, HIS58B, HIS58C, ILE279B, ILE279C, ILE289B, ILE289C, ILE325B, ILE325C, ILE426B, ILE426C, ILE429B, ILE429C, ILE74B, ILE74C, LEU153B, LEU153C, LEU199B, LEU199C, LEU233B, LEU233C, LEU248B, LEU248C, LEU251B, LEU251C, LEU284B, LEU284C, LEU302B, LEU302C, LEU309B, LEU309C, LEU316B, LEU316C, LEU323B, LEU323C, LEU327B, LEU327C, LEU345B, LEU345C, LEU357B, LEU357C, LEU362B, LEU362C, LEU369B, LEU369C, LEU372B, LEU372C, LEU385B, LEU385C, LEU415B, LEU415C, LEU441B, LEU441C, LEU62B, LEU62C, LEU69B, LEU69C, LEU73B, LEU73C, LYS258B, LYS258C, LYS452B, LYS452C, MET208B, MET208C, MET351B, MET351C, MET418B, MET418C, PHE313B, PHE313C, PHE336B, PHE336C, PHE350B, PHE350C, PHE66B, PHE66C, PRO253B, PRO253C, PRO255B, PRO255C, PRO293B, PRO293C, PRO306B, PRO306C, PRO334B, PRO334C, PRO337B, PRO337C, PRO338B, PRO338C, PRO343B, PRO343C, PRO423B, PRO423C, PRO68B, PRO68C, SER113B, SER113C, SER119B, SER119C, SER249B, SER249C, SER301B, SER301C, SER341B, SER341C, SER425B, SER425C, SER428B, SER428C, SER430B, SER430C, SER440B, SER440C, SER75B, SER75C, THR205B, THR205C, THR209B, THR209C, THR241B, THR241C, THR291B, THR291C, THR315B, THR315C, THR324B, THR324C, THR331B, THR331C, THR358B, THR358C, THR364B, THR364C, THR367B, THR367C, THR421B, THR421C, THR431B, THR431C, THR63B, THR63C, THR64B, THR64C, TRP244B, TRP244C, TRP318B, TRP318C, TYR300B, TYR300C, TYR60B, TYR60C, VAL147B, VAL147C, VAL278B, VAL278C, VAL308B, VAL308C, VAL322B, VAL322C, VAL330B, VAL330C, VAL335B, VAL335C, VAL342B, VAL342C, VAL355B, VAL355C, VAL366B, VAL366C, VAL368B, VAL368C, VAL438B, VAL438C, VAL439B, VAL439C, VAL52B, VAL52C, VAL59B, VAL59C
• B-D: ALA295B, ALA295D, ALA299B, ALA299D, ALA398B, ALA398D, ALA416B, ALA416D, ALA434B, ALA434D, ARG375B, ARG375D, ARG379B, ARG379D, ARG384B, ARG384D, ARG387B, ARG387D, ARG419B, ARG419D, ASN386B, ASN386D, ASP382B, ASP382D, GLU294B, GLU294D, GLU383B, GLU383D, HIS427B, HIS427D, ILE426B, ILE426D, ILE429B, ILE429D, LEU385B, LEU385D, PRO293B, PRO293D, PRO423B, PRO423D, SER428B, SER428D, SER430B, SER430D, THR291B, THR291D, TYR300B, TYR300D, VAL409B, VAL409D
• B-F: ALA272B, ALA272F, ALA286B, ALA286F, ARG238B, ARG238F, ARG273B, ARG273F, ARG276B, ARG276F, ARG282B, ARG282F, ARG283B, ARG283F, ARG474B, ARG474F, ASP285B, ASP285F, ASP288B, ASP288F, ASP480B, ASP480F, CYS475B, CYS475F, GLU235B, GLU235F, GLU292B, GLY287B, GLY287F, GLY290B, GLY290F, GLY481B, GLY481F, HIS277B, HIS277F, ILE289B, ILE289F, LEU284B, LEU284F, LEU479B, LEU479F, LYS487F, PRO293B, PRO293F, SER271B, SER271F, THR291B, THR291F, VAL274B, VAL274F, VAL275B, VAL275F, VAL482B, VAL482F
• B-G: ARG273B, ASP480B, GLU77G, GLY476B, SER75G
• C-D: ALA157C, ALA157D, ALA378C, ALA378D, ALA398C, ALA398D, ALA407C, ALA407D, ALA411C, ALA411D, ALA413C, ALA413D, ALA416C, ALA416D, ALA420C, ALA420D, ALA424C, ALA424D, ALA433C, ALA433D, ALA434C, ALA434D, ALA445C, ALA445D, ALA461C, ALA461D, ALA511C, ALA511D, ALA512C, ALA512D, ALA514C, ALA514D, ALA70C, ALA70D, ALA84C, ALA84D, ALA91C, ALA91D, ARG144C, ARG144D, ARG166C, ARG166D, ARG176C, ARG176D, ARG375C, ARG375D, ARG379C, ARG379D, ARG384C, ARG384D, ARG395C, ARG395D, ARG419C, ARG419D, ARG447C, ARG447D, ARG455C, ARG455D, ARG504C, ARG504D, ARG72C, ARG72D, ARG80C, ARG80D, ASN386C, ASN386D, ASN401C, ASN401D, ASN432C, ASN432D, ASN435C, ASN435D, ASN71C, ASN71D, ASN78C, ASN78D, ASN85C, ASN85D, ASP168C, ASP168D, ASP360C, ASP360D, ASP382C, ASP382D, ASP437D, ASP454C, ASP454D, ASP503C, ASP503D, GLN408C, GLN408D, GLN436C, GLN436D, GLN508C, GLN508D, GLN83C, GLN83D, GLU374C, GLU374D, GLU383C, GLU383D, GLU417C, GLU417D, GLU451C, GLU451D, GLU458C, GLU458D, GLU509C, GLU509D, GLU77C, GLU77D, GLY145C, GLY145D, GLY148C, GLY148D, GLY167C, GLY167D, GLY371C, GLY371D, GLY396C, GLY396D, GLY399C, GLY399D, GLY403C, GLY403D, GLY406C, GLY406D, GLY422C, GLY422D, GLY507C, GLY507D, GLY65C, GLY65D, GLY67C, GLY67D, GLY93C, GLY93D, GLY95C, GLY95D, HIS158C, HIS158D, HIS394C, HIS394D, HIS427C, HIS427D, HIS88C, HIS88D, ILE377C, ILE377D, ILE426C, ILE426D, ILE429C, ILE429D, ILE444C, ILE444D, ILE459C, ILE459D, ILE462C, ILE462D, ILE510C, ILE510D, ILE74C, ILE74D, LEU153C, LEU153D, LEU161C, LEU161D, LEU385C, LEU385D, LEU389C, LEU389D, LEU393C, LEU393D, LEU400C, LEU400D, LEU414C, LEU414D, LEU415C, LEU415D, LEU441C, LEU441D, LEU448C, LEU448D, LEU500C, LEU500D, LEU506C, LEU506D, LEU69C, LEU69D, LEU73C, LEU73D, LEU82C, LEU82D, LEU86C, LEU86D, LEU90C, LEU90D, LYS452C, LYS452D, MET405C, MET405D, MET418C, MET418D, PHE392C, PHE392D, PHE404C, PHE404D, PHE66C, PHE66D, PHE89C, PHE89D, PRO142C, PRO142D, PRO155D, PRO390C, PRO390D, PRO391C, PRO391D, PRO397C, PRO397D, PRO423C, PRO423D, PRO505C, PRO505D, PRO68C, PRO68D, PRO96C, PRO96D, SER143C, SER143D, SER402C, SER402D, SER425C, SER425D, SER428C, SER428D, SER430C, SER430D, SER75C, SER75D, SER92C, SER92D, THR146C, THR146D, THR154C, THR154D, THR381C, THR381D, THR410C, THR410D, THR412C, THR412D, THR421C, THR421D, THR431C, THR431D, THR443C, THR443D, THR502C, THR502D, THR64C, THR64D, THR81C, THR81D, TYR60C, TYR60D, VAL147C, VAL147D, VAL409C, VAL409D, VAL439C, VAL439D, VAL79C, VAL79D, VAL87C, VAL87D, VAL94C, VAL94D
• C-F: ARG273F, ASN78C, ASP480F, GLU77C, SER75C
• D-E: ARG273D, ASN78E, ASP480D, GLU77E, SER75E
• D-H: ALA272D, ALA272H, ALA286D, ALA286H, ARG238D, ARG238H, ARG273D, ARG273H, ARG276D, ARG276H, ARG282D, ARG474D, ARG474H, ASP285D, ASP285H, ASP288D, ASP288H, ASP480D, ASP480H, CYS475D, CYS475H, GLU235H, GLY287D, GLY287H, GLY290D, GLY290H, GLY481D, GLY481H, HIS277D, HIS277H, ILE289D, ILE289H, LEU284D, LEU284H, LEU479D, LEU479H, LYS487D, LYS487H, PRO293D, PRO293H, SER271D, SER271H, THR291H, VAL274D, VAL274H, VAL482D, VAL482H
• E-F: ALA157E, ALA157F, ALA378E, ALA378F, ALA398E, ALA398F, ALA407E, ALA407F, ALA411E, ALA411F, ALA413E, ALA413F, ALA416E, ALA416F, ALA420E, ALA420F, ALA424E, ALA424F, ALA433E, ALA433F, ALA434E, ALA434F, ALA445E, ALA445F, ALA461E, ALA461F, ALA511E, ALA511F, ALA512E, ALA512F, ALA514E, ALA514F, ALA70E, ALA70F, ALA84E, ALA84F, ALA91E, ALA91F, ARG144E, ARG144F, ARG166E, ARG166F, ARG176E, ARG176F, ARG375E, ARG375F, ARG379E, ARG379F, ARG384E, ARG384F, ARG395E, ARG395F, ARG419E, ARG419F, ARG447E, ARG447F, ARG455E, ARG455F, ARG504E, ARG504F, ARG72E, ARG72F, ARG80E, ARG80F, ASN386E, ASN386F, ASN401E, ASN401F, ASN432E, ASN432F, ASN435E, ASN435F, ASN71E, ASN71F, ASN78E, ASN78F, ASN85E, ASN85F, ASP168E, ASP168F, ASP360E, ASP360F, ASP382E, ASP382F, ASP454E, ASP454F, ASP503E, ASP503F, GLN408E, GLN408F, GLN436E, GLN436F, GLN508E, GLN508F, GLN83E, GLN83F, GLU374E, GLU374F, GLU383E, GLU383F, GLU417E, GLU417F, GLU451E, GLU451F, GLU458E, GLU458F, GLU509E, GLU509F, GLU77E, GLU77F, GLY145E, GLY145F, GLY148E, GLY148F, GLY167E, GLY167F, GLY371E, GLY371F, GLY396E, GLY396F, GLY399E, GLY399F, GLY403E, GLY403F, GLY406E, GLY406F, GLY422E, GLY422F, GLY507E, GLY507F, GLY65E, GLY65F, GLY67E, GLY67F, GLY93E, GLY93F, GLY95E, GLY95F, HIS158E, HIS158F, HIS394E, HIS394F, HIS427E, HIS427F, HIS88E, HIS88F, ILE377E, ILE377F, ILE426E, ILE426F, ILE429E, ILE429F, ILE444E, ILE444F, ILE459E, ILE459F, ILE462E, ILE462F, ILE510E, ILE510F, ILE74E, ILE74F, LEU153E, LEU153F, LEU161E, LEU161F, LEU385E, LEU385F, LEU389E, LEU389F, LEU393E, LEU393F, LEU400E, LEU400F, LEU414E, LEU414F, LEU415E, LEU415F, LEU441E, LEU441F, LEU448E, LEU448F, LEU500E, LEU500F, LEU506E, LEU506F, LEU69E, LEU69F, LEU73E, LEU73F, LEU82E, LEU82F, LEU86E, LEU86F, LEU90E, LEU90F, LYS452E, LYS452F, MET405E, MET405F, MET418E, MET418F, PHE392E, PHE392F, PHE404E, PHE404F, PHE66E, PHE66F, PHE89E, PHE89F, PRO142E, PRO142F, PRO155E, PRO390E, PRO390F, PRO391E, PRO391F, PRO397E, PRO397F, PRO423E, PRO423F, PRO505E, PRO505F, PRO68E, PRO68F, PRO96E, PRO96F, SER143E, SER143F, SER402E, SER402F, SER425E, SER425F, SER428E, SER428F, SER430E, SER430F, SER75E, SER75F, SER92E, SER92F, THR146E, THR146F, THR154E, THR154F, THR367F, THR381E, THR381F, THR410E, THR410F, THR412E, THR412F, THR421E, THR421F, THR431E, THR431F, THR443E, THR443F, THR502E, THR502F, THR64E, THR64F, THR81E, THR81F, TYR60E, TYR60F, VAL147E, VAL147F, VAL409E, VAL409F, VAL439E, VAL439F, VAL79E, VAL79F, VAL87E, VAL87F, VAL94E, VAL94F
• E-G: ALA295E, ALA295G, ALA299E, ALA299G, ALA398E, ALA398G, ALA416E, ALA416G, ALA434E, ALA434G, ARG375E, ARG375G, ARG379E, ARG379G, ARG384E, ARG384G, ARG387E, ARG387G, ARG419E, ARG419G, ASN386E, ASN386G, ASP382E, ASP382G, GLU294E, GLU294G, GLU383E, GLU383G, HIS427E, HIS427G, ILE426E, ILE426G, ILE429E, ILE429G, LEU385E, LEU385G, PRO293E, PRO293G, PRO423E, PRO423G, SER428E, SER428G, SER430E, SER430G, THR291E, THR291G, TYR300E, TYR300G, VAL409E, VAL409G
• E-H: ALA118E, ALA118H, ALA243E, ALA243H, ALA245E, ALA245H, ALA246E, ALA246H, ALA247E, ALA247H, ALA260E, ALA260H, ALA280E, ALA280H, ALA286E, ALA286H, ALA295E, ALA295H, ALA299E, ALA299H, ALA305E, ALA305H, ALA311E, ALA311H, ALA317E, ALA317H, ALA329E, ALA329H, ALA344E, ALA344H, ALA356E, ALA356H, ALA361E, ALA361H, ALA363E, ALA363H, ALA365E, ALA365H, ALA370H, ALA373E, ALA373H, ALA378E, ALA378H, ALA416E, ALA416H, ALA420E, ALA420H, ALA424E, ALA424H, ALA433E, ALA433H, ALA434E, ALA434H, ALA445E, ALA445H, ALA51E, ALA51H, ALA56E, ALA56H, ALA70E, ALA70H, ARG15E, ARG15H, ARG240E, ARG240H, ARG252E, ARG252H, ARG282E, ARG282H, ARG283E, ARG283H, ARG303E, ARG303H, ARG321E, ARG321H, ARG375E, ARG375H, ARG379E, ARG379H, ARG419E, ARG419H, ARG54E, ARG54H, ARG57E, ARG57H, ARG72E, ARG72H, ASN203E, ASN203H, ASN328E, ASN328H, ASN333E, ASN333H, ASN349E, ASN349H, ASN432E, ASN432H, ASN435E, ASN435H, ASN71E, ASN71H, ASN78E, ASN78H, ASP250E, ASP250H, ASP285E, ASP285H, ASP288E, ASP288H, ASP298E, ASP298H, ASP314E, ASP314H, ASP332E, ASP332H, ASP339E, ASP339H, ASP360E, ASP360H, ASP382E, ASP382H, ASP437E, ASP437H, CYS304E, CYS304H, GLN116E, GLN116H, GLN257E, GLN257H, GLN297E, GLN297H, GLN307E, GLN307H, GLN353E, GLN353H, GLN376E, GLN376H, GLN436E, GLN436H, GLU242E, GLU242H, GLU281E, GLU281H, GLU292E, GLU292H, GLU294E, GLU294H, GLU326E, GLU326H, GLU374E, GLU374H, GLU55E, GLU55H, GLU77E, GLU77H, GLY117E, GLY117H, GLY148E, GLY148H, GLY256E, GLY256H, GLY287E, GLY287H, GLY290E, GLY290H, GLY296E, GLY296H, GLY310E, GLY310H, GLY312E, GLY312H, GLY340E, GLY340H, GLY347E, GLY347H, GLY348E, GLY348H, GLY352E, GLY352H, GLY371E, GLY371H, GLY422E, GLY422H, GLY61E, GLY61H, GLY65E, GLY65H, GLY67E, GLY67H, GLY76E, GLY76H, HIS254E, HIS254H, HIS319E, HIS319H, HIS346E, HIS346H, HIS354E, HIS354H, HIS427E, HIS427H, HIS58E, HIS58H, ILE279E, ILE279H, ILE289E, ILE289H, ILE325E, ILE325H, ILE426E, ILE426H, ILE429E, ILE429H, ILE74E, ILE74H, LEU153E, LEU153H, LEU199E, LEU199H, LEU233E, LEU233H, LEU248E, LEU248H, LEU251E, LEU251H, LEU284E, LEU284H, LEU302E, LEU302H, LEU309E, LEU309H, LEU316E, LEU316H, LEU323E, LEU323H, LEU327E, LEU327H, LEU345E, LEU345H, LEU357E, LEU357H, LEU362E, LEU362H, LEU369E, LEU369H, LEU372E, LEU372H, LEU385E, LEU385H, LEU415E, LEU415H, LEU441E, LEU441H, LEU62E, LEU62H, LEU69E, LEU69H, LEU73E, LEU73H, LYS258E, LYS258H, LYS452E, LYS452H, MET208E, MET208H, MET351E, MET351H, MET418E, MET418H, PHE313E, PHE313H, PHE336E, PHE336H, PHE350E, PHE350H, PHE66E, PHE66H, PRO253E, PRO253H, PRO255E, PRO255H, PRO293E, PRO293H, PRO306E, PRO306H, PRO334E, PRO334H, PRO337E, PRO337H, PRO338E, PRO338H, PRO343E, PRO343H, PRO423E, PRO423H, PRO68E, PRO68H, SER113E, SER113H, SER119E, SER119H, SER249E, SER249H, SER301E, SER301H, SER341E, SER341H, SER425E, SER425H, SER428E, SER428H, SER430E, SER430H, SER440E, SER440H, SER75E, SER75H, THR205E, THR205H, THR209E, THR209H, THR241E, THR241H, THR291E, THR291H, THR315E, THR315H, THR324E, THR324H, THR331E, THR331H, THR358E, THR358H, THR364E, THR364H, THR367E, THR367H, THR421E, THR421H, THR431E, THR431H, THR63E, THR63H, THR64E, THR64H, TRP244E, TRP244H, TRP318E, TRP318H, TYR300E, TYR300H, TYR60E, TYR60H, VAL147E, VAL147H, VAL278E, VAL278H, VAL308E, VAL308H, VAL322E, VAL322H, VAL330E, VAL330H, VAL335E, VAL335H, VAL342E, VAL342H, VAL355E, VAL355H, VAL366E, VAL366H, VAL368E, VAL368H, VAL438E, VAL438H, VAL439E, VAL439H, VAL52E, VAL52H, VAL59E, VAL59H
• F-G: ALA118F, ALA118G, ALA243F, ALA243G, ALA245F, ALA245G, ALA246F, ALA246G, ALA247F, ALA247G, ALA260F, ALA260G, ALA280F, ALA280G, ALA286F, ALA286G, ALA295F, ALA295G, ALA299F, ALA299G, ALA305F, ALA305G, ALA311F, ALA311G, ALA317F, ALA317G, ALA329F, ALA329G, ALA344F, ALA344G, ALA356F, ALA356G, ALA361F, ALA361G, ALA363F, ALA363G, ALA365F, ALA365G, ALA373F, ALA373G, ALA378F, ALA378G, ALA416F, ALA416G, ALA420F, ALA420G, ALA424F, ALA424G, ALA433F, ALA433G, ALA434F, ALA434G, ALA445F, ALA445G, ALA51F, ALA51G, ALA56F, ALA56G, ALA70F, ALA70G, ARG15G, ARG240F, ARG240G, ARG252F, ARG252G, ARG282F, ARG282G, ARG283F, ARG283G, ARG303F, ARG303G, ARG321F, ARG321G, ARG375F, ARG375G, ARG379F, ARG379G, ARG419F, ARG419G, ARG54F, ARG54G, ARG57F, ARG57G, ARG72F, ARG72G, ASN203F, ASN203G, ASN328F, ASN328G, ASN333F, ASN333G, ASN349F, ASN349G, ASN432F, ASN432G, ASN435F, ASN435G, ASN71F, ASN71G, ASN78F, ASN78G, ASP250F, ASP250G, ASP285F, ASP285G, ASP288F, ASP288G, ASP298F, ASP298G, ASP314F, ASP314G, ASP332F, ASP332G, ASP339F, ASP339G, ASP360F, ASP360G, ASP382F, ASP382G, ASP437F, ASP437G, CYS304F, CYS304G, GLN116F, GLN116G, GLN257F, GLN257G, GLN297F, GLN297G, GLN307F, GLN307G, GLN353F, GLN353G, GLN376F, GLN376G, GLN436F, GLN436G, GLU242F, GLU242G, GLU281F, GLU281G, GLU292F, GLU292G, GLU294F, GLU294G, GLU326F, GLU326G, GLU374F, GLU374G, GLU55F, GLU55G, GLU77F, GLU77G, GLY117F, GLY117G, GLY148F, GLY148G, GLY256F, GLY256G, GLY287F, GLY287G, GLY290F, GLY290G, GLY296F, GLY296G, GLY310F, GLY310G, GLY312F, GLY312G, GLY340F, GLY340G, GLY347F, GLY347G, GLY348F, GLY348G, GLY352F, GLY352G, GLY371F, GLY371G, GLY422F, GLY422G, GLY61F, GLY61G, GLY65F, GLY65G, GLY67F, GLY67G, GLY76F, GLY76G, HIS254F, HIS254G, HIS319F, HIS319G, HIS346F, HIS346G, HIS354F, HIS354G, HIS427F, HIS427G, HIS58F, HIS58G, ILE279F, ILE279G, ILE289F, ILE289G, ILE325F, ILE325G, ILE426F, ILE426G, ILE429F, ILE429G, ILE74F, ILE74G, LEU153F, LEU153G, LEU199F, LEU199G, LEU233F, LEU233G, LEU248F, LEU248G, LEU251F, LEU251G, LEU284F, LEU284G, LEU302F, LEU302G, LEU309F, LEU309G, LEU316F, LEU316G, LEU323F, LEU323G, LEU327F, LEU327G, LEU345F, LEU345G, LEU357F, LEU357G, LEU362F, LEU362G, LEU369F, LEU369G, LEU372F, LEU372G, LEU385F, LEU385G, LEU415F, LEU415G, LEU441F, LEU441G, LEU62F, LEU62G, LEU69F, LEU69G, LEU73F, LEU73G, LYS258F, LYS258G, LYS452F, LYS452G, MET208F, MET208G, MET351F, MET351G, MET418F, MET418G, PHE313F, PHE313G, PHE336F, PHE336G, PHE350F, PHE350G, PHE66F, PHE66G, PRO253F, PRO253G, PRO255F, PRO255G, PRO293F, PRO293G, PRO306F, PRO306G, PRO334F, PRO334G, PRO337F, PRO337G, PRO338F, PRO338G, PRO343F, PRO343G, PRO423F, PRO423G, PRO68F, PRO68G, SER113F, SER113G, SER119F, SER119G, SER249F, SER249G, SER301F, SER301G, SER341F, SER341G, SER425F, SER425G, SER428F, SER428G, SER430F, SER430G, SER440F, SER440G, SER75F, SER75G, THR205F, THR205G, THR209F, THR209G, THR241F, THR241G, THR291F, THR291G, THR315F, THR315G, THR324F, THR324G, THR331F, THR331G, THR358F, THR358G, THR364F, THR364G, THR367F, THR367G, THR421F, THR421G, THR431F, THR431G, THR63F, THR63G, THR64F, THR64G, TRP244F, TRP244G, TRP318F, TRP318G, TYR300F, TYR300G, TYR60F, TYR60G, VAL147F, VAL147G, VAL278F, VAL278G, VAL308F, VAL308G, VAL322F, VAL322G, VAL330F, VAL330G, VAL335F, VAL335G, VAL342F, VAL342G, VAL355F, VAL355G, VAL366F, VAL366G, VAL368F, VAL368G, VAL438F, VAL438G, VAL439F, VAL439G, VAL52F, VAL52G, VAL59F, VAL59G
• F-H: ALA295F, ALA295H, ALA299F, ALA299H, ALA398F, ALA398H, ALA416F, ALA416H, ALA434F, ALA434H, ARG375F, ARG375H, ARG379F, ARG379H, ARG384F, ARG384H, ARG387F, ARG387H, ARG419F, ARG419H, ASN386F, ASN386H, ASP382F, ASP382H, GLU294F, GLU294H, GLU383F, GLU383H, GLY399H, HIS427F, HIS427H, ILE426F, ILE426H, ILE429F, ILE429H, LEU385F, LEU385H, PRO293F, PRO293H, PRO423H, SER428F, SER428H, SER430F, SER430H, THR291F, THR291H
• G-H: ALA157G, ALA157H, ALA378G, ALA378H, ALA398G, ALA398H, ALA407G, ALA407H, ALA411G, ALA411H, ALA413G, ALA413H, ALA416G, ALA416H, ALA420G, ALA420H, ALA424G, ALA424H, ALA433G, ALA433H, ALA434G, ALA434H, ALA445G, ALA445H, ALA461G, ALA461H, ALA511G, ALA511H, ALA512G, ALA512H, ALA514G, ALA514H, ALA70G, ALA70H, ALA84G, ALA84H, ALA91G, ALA91H, ARG144G, ARG144H, ARG166G, ARG166H, ARG176G, ARG176H, ARG375G, ARG375H, ARG379G, ARG379H, ARG384G, ARG384H, ARG395G, ARG395H, ARG419G, ARG419H, ARG447G, ARG447H, ARG455G, ARG455H, ARG504G, ARG504H, ARG72G, ARG72H, ARG80G, ARG80H, ASN386G, ASN386H, ASN401G, ASN401H, ASN432G, ASN432H, ASN435G, ASN435H, ASN71G, ASN71H, ASN78G, ASN78H, ASN85G, ASN85H, ASP168G, ASP168H, ASP360G, ASP360H, ASP382G, ASP382H, ASP454G, ASP454H, ASP503G, ASP503H, GLN408G, GLN408H, GLN436G, GLN436H, GLN508G, GLN508H, GLN83G, GLN83H, GLU374G, GLU374H, GLU383G, GLU383H, GLU417G, GLU417H, GLU451G, GLU451H, GLU458G, GLU458H, GLU509G, GLU509H, GLU77G, GLU77H, GLY145G, GLY145H, GLY148G, GLY148H, GLY167G, GLY167H, GLY371G, GLY371H, GLY396G, GLY396H, GLY399G, GLY399H, GLY403G, GLY403H, GLY406G, GLY406H, GLY422G, GLY422H, GLY507G, GLY507H, GLY65G, GLY65H, GLY67G, GLY67H, GLY93G, GLY93H, GLY95G, GLY95H, HIS158G, HIS158H, HIS394G, HIS394H, HIS427G, HIS427H, HIS88G, HIS88H, ILE377G, ILE377H, ILE426G, ILE426H, ILE429G, ILE429H, ILE444G, ILE444H, ILE459G, ILE459H, ILE462G, ILE462H, ILE510G, ILE510H, ILE74G, ILE74H, LEU153G, LEU153H, LEU161G, LEU161H, LEU385G, LEU385H, LEU389G, LEU389H, LEU393G, LEU393H, LEU400G, LEU400H, LEU414G, LEU414H, LEU415G, LEU415H, LEU441G, LEU441H, LEU448G, LEU448H, LEU500G, LEU500H, LEU506G, LEU506H, LEU69G, LEU69H, LEU73G, LEU73H, LEU82G, LEU82H, LEU86G, LEU86H, LEU90G, LEU90H, LYS452G, LYS452H, MET405G, MET405H, MET418G, MET418H, PHE392G, PHE392H, PHE404G, PHE404H, PHE66G, PHE66H, PHE89G, PHE89H, PRO142G, PRO142H, PRO155G, PRO390G, PRO390H, PRO391G, PRO391H, PRO397G, PRO397H, PRO423G, PRO423H, PRO505G, PRO505H, PRO68G, PRO68H, PRO96G, PRO96H, SER143G, SER143H, SER402G, SER402H, SER425G, SER425H, SER428G, SER428H, SER430G, SER430H, SER75G, SER75H, SER92G, SER92H, THR146G, THR146H, THR154G, THR154H, THR367H, THR381G, THR381H, THR410G, THR410H, THR412G, THR412H, THR421G, THR421H, THR431G, THR431H, THR443G, THR443H, THR502G, THR502H, THR64G, THR64H, THR81G, THR81H, TYR60G, TYR60H, VAL147G, VAL147H, VAL409G, VAL409H, VAL439G, VAL439H, VAL79G, VAL79H, VAL87G, VAL87H, VAL94G, VAL94H