2NYL

crystal structure of protein phosphatase 2a (pp2a) holoenzyme with the catalytic subunit carboxyl terminus truncated

• Total interactions analyzed: 28
• Total true interactions: 11
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 71
  • Norm. En. per Res.: -4.0396
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-19.873	-50.0065	-147.251	-217.1305	90	16	0	6548	4	59	35
A-C	-58.7173	-96.4312	-233.659	-388.8074	99	22	4	9868	8	53	41
B-C	-14.9402	-87.3574	-166.271	-268.5685	73	13	1	6401	3	37	24
B-G	0.0	0.0	-7.5928	-7.5928	7	0	0	265	0	1	0
C-F	0.0	0.0	-0.1353	-0.1353	4	0	0	32	0	8	7
C-G	-7.5194	5.2374	-18.4003	-20.6823	18	1	0	1140	0	3	5
D-E	-12.9485	-43.0149	-131.559	-187.5224	92	17	0	6522	4	57	33
D-F	-52.2929	-85.2065	-211.036	-348.5354	99	13	4	9295	9	51	41
E-F	-26.4453	-87.554	-172.812	-286.8113	71	14	1	6445	4	36	24
E-H	0.0	0.0	-8.0359	-8.0359	6	0	0	256	0	1	0
F-H	-6.5045	5.0871	-17.932	-19.3493	20	2	0	1216	0	2	5

Interface residues

• A-B: ALA184A, ALA296A, ARG105A, ARG182A, ARG183A, ARG200B, ARG221A, ARG258A, ARG260A, ARG95B, ASN195B, ASN196B, ASP139A, ASP162B, ASP176A, ASP177A, ASP215A, ASP218A, ASP254A, ASP61A, ASP63A, GLN151B, GLN156B, GLN193B, GLN217A, GLN26A, GLU100A, GLU101A, GLU159B, GLU204B, GLU206B, GLU216A, GLU295A, GLU297A, GLU62A, GLU64A, HIS207B, ILE197B, ILE202B, ILE235B, ILE59A, LEU155B, LEU158B, LEU222A, LEU223A, LEU238B, LEU66A, LEU97B, LYS152B, LYS192B, LYS239B, LYS246B, LYS255A, LYS281B, LYS285B, PHE141A, PHE198B, PHE201B, PHE236B, PHE94B, PRO179A, PRO243B, PRO98B, PRO99B, SER100B, SER219A, SER256A, THR102A, THR142A, THR145A, THR178A, THR205B, THR96B, THR98A, TRP140A, TRP257A, TYR189B, TYR199B, TYR203B, TYR261A, TYR282B, TYR60A, VAL103A, VAL181A, VAL220A, VAL240B, VAL259A, VAL25A, VAL298A, VAL99A
• A-C: ALA292C, ALA415A, ALA457A, ALA534A, ARG106C, ARG108C, ARG110C, ARG294C, ARG418A, ARG420A, ARG459A, ARG498A, ARG49C, ARG537A, ARG70C, ASN494A, ASN535A, ASN539A, ASN79C, ASP11C, ASP279C, ASP280C, ASP290C, ASP453A, ASP492A, ASP531A, ASP572A, ASP574A, ASP64C, ASP77C, CYS50C, GLN26A, GLN272C, GLN288C, GLN571A, GLN580A, GLU109C, GLU277C, GLU379A, GLU3C, GLU460A, GLU581A, GLU67C, GLY138C, GLY72C, GLY73C, HIS454A, HIS497A, ILE111C, ILE275C, ILE458A, ILE71C, LEU278C, LEU287C, LEU382A, LEU421A, LEU496A, LEU68C, LYS283C, LYS416A, LYS4C, LYS542A, LYS576A, LYS74C, LYS8C, MET66C, PHE286C, PHE289C, PHE503A, PHE538A, PHE578A, PHE69C, PRO291C, PRO293C, PRO378A, PRO493A, PRO51C, PRO532A, PRO76C, SER285C, SER75C, THR281C, THR500A, THR53C, THR584A, THR78C, THR7C, TRP417A, TYR107C, TYR456A, TYR495A, TYR577A, TYR80C, VAL455A, VAL52C, VAL533A, VAL536A, VAL573A, VAL575A
• B-C: ALA106B, ALA140C, ARG121C, ARG135C, ARG268C, ARG294C, ARG89C, ASN102B, ASN139C, ASN264C, ASN373B, ASP109B, ASP113B, ASP131C, ASP148C, CYS133C, CYS266C, CYS269C, GLN122C, GLN125C, GLN331B, GLU107B, GLU111B, GLU112B, GLU114B, GLU132C, GLU188C, GLU291B, GLY105B, GLY128C, GLY138C, GLY270C, GLY90C, HIS191C, HIS287B, HIS329B, HIS371B, HIS63C, ILE123C, LEU134C, LYS136C, LYS144C, LYS248B, LYS285B, LYS290B, LYS374B, PHE108B, PHE330B, PRO103B, PRO110B, PRO289B, PRO328B, SER101B, SER120C, SER288B, SER327B, THR104B, THR124C, THR147C, THR286B, THR370B, THR375B, TRP143C, TRP372B, TYR127C, TYR130C, TYR137C, TYR265C, TYR267C, TYR91C, TYR92C, VAL126C, VAL332B
• B-G: ASP109B, ASP113B, GLU111B, GLU112B, GLU114B, LEU2G, PHE108B
• C-F: ARG206C, ARG206F, GLN222C, GLN222F
• C-G: ALA216C, ARG214C, ARG268C, ARG4G, ARG89C, ASN117C, CYS266C, CYS269C, GLY215C, HIS118C, HIS241C, LEU2G, PRO213C, SER212C, TRP200C, TYR127C, TYR265C, TYR267C
• D-E: ALA184D, ALA296D, ARG105D, ARG182D, ARG183D, ARG200E, ARG221D, ARG258D, ARG260D, ARG95E, ASN195E, ASN196E, ASN209E, ASP106D, ASP162E, ASP176D, ASP177D, ASP215D, ASP218D, ASP254D, ASP61D, ASP63D, GLN151E, GLN156E, GLN193E, GLN217D, GLN26D, GLU100D, GLU101D, GLU159E, GLU204E, GLU206E, GLU216D, GLU295D, GLU297D, GLU62D, GLU64D, HIS207E, ILE197E, ILE202E, ILE235E, ILE59D, LEU155E, LEU158E, LEU222D, LEU223D, LEU238E, LEU66D, LEU97E, LYS152E, LYS192E, LYS239E, LYS246E, LYS255D, LYS281E, LYS285E, PHE141D, PHE198E, PHE201E, PHE236E, PHE94E, PRO179D, PRO243E, PRO98E, PRO99E, SER100E, SER219D, SER256D, THR102D, THR142D, THR145D, THR178D, THR205E, THR96E, THR98D, TRP140D, TRP257D, TYR189E, TYR199E, TYR203E, TYR261D, TYR282E, TYR60D, VAL103D, VAL104D, VAL181D, VAL220D, VAL240E, VAL259D, VAL25D, VAL298D, VAL99D
• D-F: ALA292F, ALA415D, ALA457D, ALA534D, ARG106F, ARG108F, ARG110F, ARG294F, ARG418D, ARG420D, ARG459D, ARG498D, ARG49F, ARG537D, ARG70F, ASN494D, ASN535D, ASN539D, ASN79F, ASP11F, ASP279F, ASP280F, ASP290F, ASP453D, ASP492D, ASP531D, ASP572D, ASP574D, ASP64F, ASP77F, CYS50F, GLN26D, GLN272F, GLN288F, GLN571D, GLN580D, GLU109F, GLU277F, GLU379D, GLU3F, GLU460D, GLU581D, GLU67F, GLY138F, GLY72F, GLY73F, HIS454D, HIS497D, ILE111F, ILE275F, ILE458D, ILE71F, LEU278F, LEU287F, LEU382D, LEU421D, LEU496D, LEU68F, LYS283F, LYS416D, LYS4F, LYS542D, LYS576D, LYS74F, LYS8F, MET66F, PHE286F, PHE289F, PHE503D, PHE538D, PHE578D, PHE69F, PRO291F, PRO293F, PRO378D, PRO493D, PRO51F, PRO532D, PRO76F, SER285F, SER75F, THR281F, THR500D, THR53F, THR584D, THR78F, THR7F, TRP417D, TYR107F, TYR456D, TYR495D, TYR577D, TYR80F, VAL455D, VAL52F, VAL533D, VAL536D, VAL573D, VAL575D
• E-F: ALA106E, ALA140F, ARG121F, ARG135F, ARG268F, ARG294F, ARG89F, ASN102E, ASN139F, ASN264F, ASN373E, ASP109E, ASP113E, ASP131F, ASP148F, CYS133F, CYS266F, CYS269F, GLN122F, GLN125F, GLN331E, GLU107E, GLU111E, GLU112E, GLU114E, GLU132F, GLU188F, GLU291E, GLY105E, GLY128F, GLY138F, GLY270F, GLY90F, HIS191F, HIS287E, HIS329E, HIS371E, ILE123F, LEU134F, LYS136F, LYS144F, LYS248E, LYS285E, LYS290E, LYS374E, PHE108E, PHE330E, PRO103E, PRO110E, PRO289E, PRO328E, SER101E, SER120F, SER288E, SER327E, THR104E, THR124F, THR147F, THR286E, THR370E, THR375E, TRP143F, TRP372E, TYR127F, TYR130F, TYR137F, TYR267F, TYR91F, TYR92F, VAL126F, VAL332E
• E-H: ASP109E, ASP113E, GLU111E, GLU112E, GLU114E, LEU2H
• F-H: ALA216F, ARG214F, ARG268F, ARG4H, ARG89F, ASN117F, ASN264F, CYS266F, CYS269F, GLY215F, HIS118F, HIS241F, LEU243F, LEU2H, PRO213F, SER212F, TRP200F, TYR127F, TYR265F, TYR267F