2NX3

structural and mechanistic changes along an engineered path from metallo to non-metallo kdo8p synthase

• Total interactions analyzed: 66
• Total true interactions: 24
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 150
  • Norm. En. per Res.: -4.0561
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-119.02	-33.9262	-443.256	-596.2021	151	14	7	16993	10	39	55
A-C	0.0	0.0	-42.2344	-42.2344	20	1	0	1364	0	0	0
A-D	-56.5903	-16.9632	-362.976	-436.5295	132	9	20	15537	8	28	26
A-G	-7.0072	-7.4087	-64.3828	-78.7988	44	2	1	2418	2	16	21
A-H	0.0	-7.2534	-12.5331	-19.7865	12	0	0	565	0	13	7
B-C	-51.442	-28.0323	-362.913	-442.3873	127	16	21	15678	8	27	28
B-D	0.0	0.0	-44.5415	-44.5415	20	2	0	1365	0	0	0
B-G	-13.7609	-32.4984	-28.165	-74.4243	37	1	0	1386	2	19	19
C-D	-124.3016	-33.745	-435.665	-593.7117	153	19	8	16990	9	38	54
E-F	-97.2431	-33.9987	-428.662	-559.9038	152	23	7	16867	11	38	53
E-G	0.0	0.0	-48.0424	-48.0424	18	0	0	1385	0	0	0
E-H	-51.3709	-20.356	-356.606	-428.3329	131	13	22	15536	8	27	27
F-G	-48.46	-6.9443	-340.385	-395.7893	133	13	21	15319	7	27	26
F-H	0.0	0.0	-44.6496	-44.6496	19	2	0	1394	0	0	0
G-H	-137.5527	-34.5776	-436.28	-608.4103	150	14	8	16850	10	39	55
G-I	0.0	-5.9577	-12.5951	-18.5528	12	0	0	569	0	12	6
G-J	-9.323	9.4956	-56.2698	-56.0972	43	1	1	2218	1	15	20
H-J	-3.2637	-20.7368	-33.4107	-57.4112	36	1	0	1235	1	18	21
I-J	-114.4979	-26.1622	-445.677	-586.3371	152	15	7	16993	9	38	52
I-K	0.0	0.0	-45.97	-45.97	20	1	0	1372	0	0	0
I-L	-67.0715	-26.8714	-359.135	-453.0779	133	10	22	15544	8	28	28
J-K	-39.6495	-17.7183	-347.323	-404.6908	130	19	23	15451	6	26	26
J-L	0.0	0.0	-45.4014	-45.4014	20	1	0	1397	0	0	0
K-L	-107.375	-18.6229	-443.328	-569.326	153	19	8	17155	8	37	51

Interface residues

• A-B: ALA102A, ALA102B, ALA113A, ALA113B, ALA130A, ALA130B, ALA47A, ALA47B, ARG106A, ARG106B, ARG154A, ARG154B, ARG168A, ARG168B, ARG49A, ARG49B, ARG56A, ARG56B, ASN136A, ASN136B, ASN161A, ASN161B, ASN162A, ASN162B, ASN48A, ASN48B, ASP109A, ASP109B, ASP133A, ASP133B, ASP166A, ASP166B, ASP195A, ASP195B, ASP45A, ASP45B, CYS105A, CYS105B, GLN107A, GLN107B, GLN127A, GLN127B, GLN188A, GLN188B, GLN87A, GLN87B, GLU139A, GLU139B, GLU153A, GLU153B, GLU84A, GLU84B, GLY126A, GLY126B, GLY144A, GLY144B, GLY155A, GLY155B, GLY159A, GLY159B, GLY191A, GLY191B, GLY192A, GLY192B, GLY194A, GLY194B, HIS53A, HIS53B, HIS83A, HIS83B, ILE172A, ILE172B, ILE52A, ILE52B, ILE82A, ILE82B, LEU104A, LEU104B, LEU110A, LEU110B, LEU111A, LEU111B, LEU112A, LEU112B, LEU129A, LEU129B, LEU141A, LEU141B, LEU163A, LEU163B, LEU193A, LEU193B, LYS125A, LYS125B, LYS135A, LYS135B, LYS140A, LYS140B, LYS142A, LYS142B, LYS196A, LYS196B, LYS46A, LYS46B, PHE103A, PHE103B, PHE128A, PHE128B, PHE143A, PHE143B, PHE158A, PHE158B, PHE167A, PHE167B, PRO101A, PRO101B, PRO131A, PRO131B, PRO190A, PRO190B, SER169A, SER169B, SER197A, SER197B, SER50A, SER50B, SER51A, SER51B, SER54A, SER54B, SER85A, SER85B, THR108A, THR108B, THR156A, THR156B, THR157A, THR157B, TRP132A, TRP132B, TRP86A, TRP86B, TYR160A, TYR160B, VAL137A, VAL137B, VAL138B, VAL164A, VAL164B, VAL165A, VAL165B
• A-C: ASN161A, ASN161C, ASN162A, ASN162C, GLY159A, GLY159C, LEU163A, LEU163C, LEU189A, LEU189C, MET200A, MET200C, PHE158A, PHE158C, THR157A, THR157C, TYR160A, TYR160C, VAL164A, VAL164C
• A-D: ALA130A, ALA130D, ALA210A, ALA210D, ALA211A, ALA211D, ALA213A, ALA213D, ALA249A, ALA249D, ALA257A, ALA257D, ARG168A, ARG168D, ARG201D, ARG209A, ARG209D, ARG254A, ARG254D, ASN161A, ASN161D, ASN162A, ASN162D, ASP166A, ASP166D, GLN127A, GLN127D, GLN175A, GLN175D, GLN188A, GLN188D, GLU202A, GLU202D, GLU248A, GLU248D, GLU252A, GLU252D, GLU255A, GLU255D, GLU262A, GLU262D, GLY155A, GLY155D, GLY159A, GLY159D, GLY199A, GLY199D, GLY215A, GLY215D, GLY245A, GLY245D, ILE172A, ILE172D, ILE204A, ILE204D, ILE208A, ILE208D, ILE246A, ILE246D, ILE247D, ILE250A, ILE250D, ILE253A, ILE253D, LEU129A, LEU129D, LEU163A, LEU163D, LEU170A, LEU170D, LEU189A, LEU189D, LEU207A, LEU207D, LEU251A, LEU251D, LYS125A, LYS174D, LYS259A, LYS259D, MET173A, MET173D, MET200A, MET200D, PHE128A, PHE128D, PHE158A, PHE158D, PHE167A, PHE167D, PHE203A, PHE203D, PHE205A, PHE205D, PRO131A, PRO131D, PRO171A, PRO171D, PRO190A, PRO190D, PRO206A, PRO206D, SER169A, SER169D, SER186A, SER186D, SER258A, SER258D, THR156A, THR156D, THR157A, THR157D, THR263D, TRP132A, TRP132D, TYR181A, TYR260A, TYR260D, TYR261A, TYR261D, VAL164A, VAL164D, VAL165A, VAL165D, VAL187A, VAL187D, VAL212A, VAL212D, VAL214A, VAL214D, VAL256A, VAL256D
• A-G: ALA146G, ALA47A, ALA66A, ARG119G, ARG56A, ASN136G, ASP45A, GLN87A, GLU139G, GLU14A, GLU16A, GLU17A, GLU61A, GLY118G, GLY144G, GLY145G, GLY57A, GLY59A, GLY63A, HIS53A, HIS58A, ILE13A, ILE52A, LEU112G, LEU141G, LEU231A, LEU60A, LYS116G, LYS135G, LYS140G, LYS142G, LYS147G, LYS46A, LYS65A, PHE143G, PHE44A, PHE55A, SER15A, SER54A, THR117G, TRP176G, TRP86A, TYR62A, VAL138G
• A-H: ALA66A, ASP195H, GLU16A, GLU61A, GLY63A, HIS53H, HIS58A, ILE52H, LYS65A, LYS69A, SER51H, TYR62A
• B-C: ALA130B, ALA130C, ALA210B, ALA210C, ALA211B, ALA211C, ALA213B, ALA213C, ALA249B, ALA249C, ALA257B, ALA257C, ARG168B, ARG168C, ARG201B, ARG209B, ARG209C, ARG254B, ARG254C, ASN161B, ASN161C, ASN162B, ASN162C, ASP166B, ASP166C, CYS216B, GLN127B, GLN127C, GLN175B, GLN175C, GLN188B, GLN188C, GLU202B, GLU202C, GLU248B, GLU248C, GLU252B, GLU252C, GLU255B, GLU255C, GLU262B, GLU262C, GLY159B, GLY159C, GLY199B, GLY199C, GLY215B, GLY215C, GLY245B, GLY245C, ILE172B, ILE172C, ILE204B, ILE204C, ILE208B, ILE208C, ILE246B, ILE246C, ILE247C, ILE250B, ILE250C, ILE253B, ILE253C, LEU129B, LEU129C, LEU163B, LEU163C, LEU170B, LEU170C, LEU189B, LEU189C, LEU207B, LEU207C, LEU251B, LEU251C, LYS259B, LYS259C, MET173B, MET173C, MET200B, MET200C, PHE128B, PHE128C, PHE158B, PHE158C, PHE167B, PHE167C, PHE203B, PHE203C, PHE205B, PHE205C, PRO131B, PRO131C, PRO171B, PRO171C, PRO190B, PRO190C, PRO206B, PRO206C, SER169B, SER169C, SER186B, SER186C, SER258B, SER258C, THR156B, THR156C, THR157B, THR157C, TRP132B, TRP132C, TYR260B, TYR260C, TYR261B, TYR261C, VAL164B, VAL164C, VAL165B, VAL165C, VAL187B, VAL187C, VAL212B, VAL212C, VAL214B, VAL214C, VAL256B, VAL256C
• B-D: ASN161B, ASN161D, ASN162B, ASN162D, GLY159B, GLY159D, LEU163B, LEU163D, LEU189B, LEU189D, MET200B, MET200D, PHE158B, PHE158D, THR157B, THR157D, TYR160B, TYR160D, VAL164B, VAL164D
• B-G: ALA115B, ALA120G, ALA92B, ALA92G, ARG119G, ASP109B, ASP96G, GLU148G, GLU35G, GLU37G, GLU72G, GLU89B, GLU93B, GLU93G, GLY118B, GLY118G, GLY144B, GLY145B, GLY75G, ILE97G, LEU112B, LEU5G, LYS116B, LYS116G, LYS140B, LYS142B, LYS147B, LYS147G, LYS178G, LYS3G, LYS71G, LYS77G, PHE143B, THR108B, THR117B, THR117G, TYR150G
• C-D: ALA102C, ALA102D, ALA113C, ALA113D, ALA130C, ALA130D, ALA47C, ALA47D, ARG106C, ARG106D, ARG154C, ARG154D, ARG168C, ARG168D, ARG49C, ARG49D, ARG56C, ARG56D, ASN136C, ASN136D, ASN161C, ASN161D, ASN162C, ASN162D, ASN48C, ASN48D, ASP109C, ASP109D, ASP133C, ASP133D, ASP166C, ASP166D, ASP195C, ASP195D, ASP45C, ASP45D, CYS105C, CYS105D, GLN107C, GLN107D, GLN127C, GLN127D, GLN188C, GLN188D, GLN87C, GLN87D, GLU139C, GLU139D, GLU153C, GLU153D, GLU84C, GLU84D, GLY126C, GLY126D, GLY144C, GLY144D, GLY155C, GLY155D, GLY159C, GLY159D, GLY191C, GLY191D, GLY192C, GLY192D, GLY194C, GLY194D, HIS53C, HIS53D, HIS83C, HIS83D, ILE172C, ILE172D, ILE52C, ILE52D, ILE82C, ILE82D, LEU104C, LEU104D, LEU110C, LEU110D, LEU111C, LEU111D, LEU112C, LEU112D, LEU129C, LEU129D, LEU141C, LEU141D, LEU163C, LEU163D, LEU189C, LEU193C, LEU193D, LYS125C, LYS125D, LYS135C, LYS135D, LYS140C, LYS140D, LYS142C, LYS142D, LYS196C, LYS196D, LYS46C, LYS46D, PHE103C, PHE103D, PHE128C, PHE128D, PHE143C, PHE143D, PHE158C, PHE158D, PHE167C, PHE167D, PRO101C, PRO101D, PRO131C, PRO131D, PRO190C, PRO190D, SER169C, SER169D, SER197C, SER197D, SER50C, SER50D, SER51C, SER51D, SER54C, SER54D, SER85C, SER85D, THR108C, THR108D, THR156C, THR156D, THR157C, THR157D, TRP132C, TRP132D, TRP86C, TRP86D, TYR160C, TYR160D, VAL137C, VAL137D, VAL138C, VAL138D, VAL164C, VAL164D, VAL165C, VAL165D
• E-F: ALA102E, ALA102F, ALA113E, ALA113F, ALA130E, ALA130F, ALA47E, ALA47F, ARG106E, ARG106F, ARG154E, ARG154F, ARG168E, ARG168F, ARG49E, ARG49F, ARG56E, ARG56F, ASN136E, ASN136F, ASN161E, ASN161F, ASN162E, ASN162F, ASN48E, ASN48F, ASP109E, ASP109F, ASP133E, ASP133F, ASP166E, ASP166F, ASP195E, ASP195F, ASP45E, ASP45F, CYS105E, CYS105F, GLN107E, GLN107F, GLN127E, GLN127F, GLN188E, GLN188F, GLN87E, GLN87F, GLU139E, GLU139F, GLU153E, GLU153F, GLU84E, GLU84F, GLY126E, GLY126F, GLY144E, GLY144F, GLY155E, GLY155F, GLY159E, GLY159F, GLY191E, GLY191F, GLY192E, GLY192F, GLY194E, GLY194F, HIS53E, HIS53F, HIS83E, HIS83F, ILE100E, ILE172E, ILE172F, ILE52E, ILE52F, ILE82E, ILE82F, LEU104E, LEU104F, LEU110E, LEU110F, LEU111E, LEU111F, LEU112E, LEU112F, LEU129E, LEU129F, LEU141E, LEU141F, LEU163E, LEU163F, LEU193E, LEU193F, LYS125E, LYS125F, LYS135E, LYS135F, LYS140E, LYS140F, LYS142E, LYS142F, LYS196E, LYS196F, LYS46E, LYS46F, PHE103E, PHE103F, PHE128E, PHE128F, PHE143E, PHE143F, PHE158E, PHE158F, PHE167E, PHE167F, PRO101E, PRO101F, PRO131E, PRO131F, PRO190E, PRO190F, SER169E, SER169F, SER197E, SER197F, SER50E, SER50F, SER51E, SER51F, SER54E, SER54F, SER85E, SER85F, THR108E, THR108F, THR156E, THR156F, THR157E, THR157F, TRP132E, TRP132F, TRP86E, TRP86F, TYR160E, TYR160F, VAL137E, VAL137F, VAL138E, VAL164E, VAL164F, VAL165E, VAL165F
• E-G: ASN161E, ASN161G, ASN162E, ASN162G, GLY159E, GLY159G, LEU163E, LEU163G, LEU189G, MET200G, PHE158E, PHE158G, THR157E, THR157G, TYR160E, TYR160G, VAL164E, VAL164G
• E-H: ALA130E, ALA130H, ALA210E, ALA210H, ALA211E, ALA211H, ALA213E, ALA213H, ALA249E, ALA249H, ALA257E, ALA257H, ARG168E, ARG168H, ARG209E, ARG209H, ARG254E, ARG254H, ASN161E, ASN161H, ASN162E, ASN162H, ASP166E, ASP166H, GLN127E, GLN127H, GLN175E, GLN175H, GLN188E, GLN188H, GLU202E, GLU202H, GLU248E, GLU248H, GLU252E, GLU252H, GLU255E, GLU255H, GLU262E, GLU262H, GLY155E, GLY159E, GLY159H, GLY199E, GLY199H, GLY215E, GLY215H, GLY245E, GLY245H, ILE172E, ILE172H, ILE204E, ILE204H, ILE208E, ILE208H, ILE246E, ILE246H, ILE247E, ILE247H, ILE250E, ILE250H, ILE253E, ILE253H, LEU129E, LEU129H, LEU163E, LEU163H, LEU170E, LEU170H, LEU189E, LEU189H, LEU207E, LEU207H, LEU251E, LEU251H, LYS174E, LYS259E, LYS259H, MET173E, MET173H, MET200E, MET200H, PHE128E, PHE128H, PHE158E, PHE158H, PHE167E, PHE167H, PHE203E, PHE203H, PHE205E, PHE205H, PRO131E, PRO131H, PRO171E, PRO171H, PRO190E, PRO190H, PRO206E, PRO206H, SER169E, SER169H, SER186E, SER186H, SER258E, SER258H, THR156E, THR156H, THR157E, THR157H, THR263E, THR263H, TRP132E, TRP132H, TYR181E, TYR260E, TYR260H, TYR261E, TYR261H, VAL164E, VAL164H, VAL165E, VAL165H, VAL187E, VAL187H, VAL212E, VAL212H, VAL214E, VAL214H, VAL256E, VAL256H
• F-G: ALA130F, ALA130G, ALA210F, ALA210G, ALA211F, ALA211G, ALA213F, ALA213G, ALA249F, ALA249G, ALA257F, ALA257G, ARG168F, ARG168G, ARG201F, ARG209F, ARG209G, ARG254F, ARG254G, ASN161F, ASN161G, ASN162F, ASN162G, ASP166F, ASP166G, GLN127F, GLN127G, GLN175F, GLN175G, GLN188F, GLN188G, GLU202F, GLU202G, GLU248F, GLU248G, GLU252F, GLU252G, GLU255F, GLU255G, GLU262F, GLU262G, GLY155F, GLY155G, GLY159F, GLY159G, GLY199F, GLY199G, GLY215F, GLY215G, GLY245F, GLY245G, ILE172F, ILE172G, ILE204F, ILE204G, ILE208F, ILE208G, ILE246F, ILE246G, ILE247F, ILE247G, ILE250F, ILE250G, ILE253F, ILE253G, LEU129F, LEU129G, LEU163F, LEU163G, LEU170F, LEU170G, LEU189F, LEU189G, LEU207F, LEU207G, LEU251F, LEU251G, LYS125G, LYS174F, LYS259F, LYS259G, MET173F, MET173G, MET200F, MET200G, PHE128F, PHE128G, PHE158F, PHE158G, PHE167F, PHE167G, PHE203F, PHE203G, PHE205F, PHE205G, PRO131F, PRO131G, PRO171F, PRO171G, PRO190F, PRO190G, PRO206F, PRO206G, SER169F, SER169G, SER186F, SER186G, SER258F, SER258G, THR156F, THR156G, THR157F, THR157G, THR263G, TRP132F, TRP132G, TYR181F, TYR260F, TYR260G, TYR261F, TYR261G, VAL164F, VAL164G, VAL165F, VAL165G, VAL187F, VAL187G, VAL212F, VAL212G, VAL214F, VAL214G, VAL256F, VAL256G
• F-H: ASN161F, ASN161H, ASN162F, ASN162H, GLY159F, GLY159H, LEU163F, LEU163H, LEU189F, MET200F, MET200H, PHE158F, PHE158H, THR157F, THR157H, TYR160F, TYR160H, VAL164F, VAL164H
• G-H: ALA102G, ALA102H, ALA113G, ALA113H, ALA130G, ALA130H, ALA47G, ALA47H, ARG106G, ARG106H, ARG154G, ARG154H, ARG168G, ARG168H, ARG49G, ARG49H, ARG56G, ARG56H, ASN136G, ASN136H, ASN161G, ASN161H, ASN162G, ASN162H, ASN48G, ASN48H, ASP109G, ASP109H, ASP133G, ASP133H, ASP166G, ASP166H, ASP195G, ASP195H, ASP45G, ASP45H, CYS105G, CYS105H, GLN107G, GLN107H, GLN127G, GLN127H, GLN188G, GLN188H, GLN87G, GLN87H, GLU139G, GLU139H, GLU153G, GLU153H, GLU84G, GLU84H, GLY126G, GLY126H, GLY144G, GLY144H, GLY155G, GLY155H, GLY159G, GLY159H, GLY191G, GLY191H, GLY192G, GLY192H, GLY194G, GLY194H, HIS53G, HIS53H, HIS83G, HIS83H, ILE172G, ILE172H, ILE52G, ILE52H, ILE82G, ILE82H, LEU104G, LEU104H, LEU110G, LEU110H, LEU111G, LEU111H, LEU112G, LEU112H, LEU129G, LEU129H, LEU141G, LEU141H, LEU163G, LEU163H, LEU193G, LEU193H, LYS125G, LYS125H, LYS135G, LYS135H, LYS140G, LYS140H, LYS142G, LYS142H, LYS196G, LYS196H, LYS46G, LYS46H, PHE103G, PHE103H, PHE128G, PHE128H, PHE143G, PHE143H, PHE158G, PHE158H, PHE167G, PHE167H, PRO101G, PRO101H, PRO131G, PRO131H, PRO190G, PRO190H, SER169G, SER169H, SER197G, SER197H, SER50G, SER50H, SER51G, SER51H, SER54G, SER54H, SER85G, SER85H, THR108G, THR108H, THR156G, THR156H, THR157G, THR157H, TRP132G, TRP132H, TRP86G, TRP86H, TYR160G, TYR160H, VAL137G, VAL137H, VAL164G, VAL164H, VAL165G, VAL165H
• G-I: ALA66G, ASP195I, GLU16G, GLU61G, GLY63G, HIS53I, HIS58G, ILE52I, LYS65G, LYS69G, SER51I, TYR62G
• G-J: ALA146J, ALA47G, ALA66G, ARG119J, ARG56G, ASN136J, ASP45G, GLN87G, GLU139J, GLU14G, GLU16G, GLU17G, GLU61G, GLY118J, GLY144J, GLY145J, GLY57G, GLY59G, GLY63G, HIS53G, HIS58G, ILE13G, ILE52G, LEU112J, LEU141J, LEU60G, LYS116J, LYS135J, LYS140J, LYS142J, LYS147J, LYS46G, LYS65G, PHE143J, PHE44G, PHE55G, SER15G, SER54G, THR117J, TRP176J, TRP86G, TYR62G, VAL138J
• H-J: ALA115J, ALA120J, ALA92J, ARG119J, ASP109H, ASP96J, GLU148J, GLU37J, GLU72J, GLU89H, GLU93H, GLU93J, GLY118J, GLY144H, GLY145H, GLY75J, ILE97J, ILE98J, LEU112H, LEU5J, LYS116H, LYS116J, LYS140H, LYS142H, LYS147H, LYS147J, LYS178J, LYS3J, LYS71J, LYS77J, PHE143H, THR108H, THR117H, THR117J, TYR150J, VAL39J
• I-J: ALA102I, ALA102J, ALA113I, ALA113J, ALA130I, ALA130J, ALA47I, ALA47J, ARG106I, ARG106J, ARG154I, ARG154J, ARG168I, ARG168J, ARG49I, ARG49J, ARG56I, ARG56J, ASN136I, ASN136J, ASN161I, ASN161J, ASN162I, ASN162J, ASN48I, ASN48J, ASP109I, ASP109J, ASP133I, ASP133J, ASP166I, ASP166J, ASP195I, ASP195J, ASP233J, ASP45I, ASP45J, CYS105I, CYS105J, GLN107I, GLN107J, GLN127I, GLN127J, GLN188I, GLN188J, GLN87I, GLN87J, GLU139I, GLU139J, GLU153I, GLU153J, GLU84I, GLU84J, GLY126I, GLY126J, GLY144I, GLY144J, GLY155I, GLY155J, GLY159I, GLY159J, GLY191I, GLY191J, GLY192I, GLY192J, GLY194I, GLY194J, HIS53I, HIS53J, HIS83I, HIS83J, ILE172I, ILE172J, ILE52I, ILE52J, ILE82I, ILE82J, LEU104I, LEU104J, LEU110I, LEU110J, LEU111I, LEU111J, LEU112I, LEU112J, LEU129I, LEU129J, LEU141I, LEU141J, LEU163I, LEU163J, LEU189J, LEU193I, LEU193J, LYS125I, LYS125J, LYS135I, LYS135J, LYS140I, LYS140J, LYS142I, LYS142J, LYS196I, LYS196J, LYS46I, LYS46J, PHE103I, PHE103J, PHE128I, PHE128J, PHE143I, PHE143J, PHE158I, PHE158J, PHE167I, PHE167J, PRO101I, PRO101J, PRO131I, PRO131J, PRO190I, PRO190J, SER169I, SER169J, SER197I, SER197J, SER50I, SER50J, SER51I, SER51J, SER54I, SER54J, SER85I, SER85J, THR108I, THR108J, THR156I, THR156J, THR157I, THR157J, TRP132I, TRP132J, TRP86I, TRP86J, TYR160I, TYR160J, VAL137I, VAL137J, VAL164I, VAL164J, VAL165I, VAL165J
• I-K: ASN161I, ASN161K, ASN162I, ASN162K, GLY159I, GLY159K, LEU163I, LEU163K, LEU189I, LEU189K, MET200I, MET200K, PHE158I, PHE158K, THR157I, THR157K, TYR160I, TYR160K, VAL164I, VAL164K
• I-L: ALA130I, ALA130L, ALA210I, ALA210L, ALA211I, ALA211L, ALA213I, ALA213L, ALA249I, ALA249L, ALA257I, ALA257L, ARG168I, ARG168L, ARG209I, ARG209L, ARG254I, ARG254L, ASN161I, ASN161L, ASN162I, ASN162L, ASP166I, ASP166L, CYS216L, GLN127I, GLN127L, GLN175I, GLN175L, GLN188I, GLN188L, GLU202I, GLU202L, GLU248I, GLU248L, GLU252I, GLU252L, GLU255I, GLU255L, GLU262I, GLU262L, GLY155I, GLY155L, GLY159I, GLY159L, GLY199I, GLY199L, GLY215I, GLY215L, GLY245I, GLY245L, HIS185L, ILE172I, ILE172L, ILE204I, ILE204L, ILE208I, ILE208L, ILE246I, ILE246L, ILE247L, ILE250I, ILE250L, ILE253I, ILE253L, ILE264I, LEU129I, LEU129L, LEU163I, LEU163L, LEU170I, LEU170L, LEU189I, LEU189L, LEU207I, LEU207L, LEU251I, LEU251L, LYS125I, LYS125L, LYS259I, LYS259L, MET173I, MET173L, MET200I, MET200L, PHE128I, PHE128L, PHE158I, PHE158L, PHE167I, PHE167L, PHE203I, PHE203L, PHE205I, PHE205L, PRO131I, PRO131L, PRO171I, PRO171L, PRO190I, PRO190L, PRO206I, PRO206L, SER169I, SER169L, SER186I, SER186L, SER258I, SER258L, THR156I, THR156L, THR157I, THR157L, TRP132I, TRP132L, TYR181I, TYR260I, TYR260L, TYR261I, TYR261L, VAL164I, VAL164L, VAL165I, VAL165L, VAL187I, VAL187L, VAL212I, VAL212L, VAL214I, VAL214L, VAL256I, VAL256L
• J-K: ALA130J, ALA130K, ALA210J, ALA210K, ALA211J, ALA211K, ALA213J, ALA213K, ALA249J, ALA249K, ALA257J, ALA257K, ARG168J, ARG168K, ARG209J, ARG209K, ARG254J, ARG254K, ASN161J, ASN161K, ASN162J, ASN162K, ASP166J, ASP166K, CYS216J, GLN127J, GLN127K, GLN175J, GLN175K, GLN188J, GLN188K, GLU202J, GLU202K, GLU248J, GLU248K, GLU252J, GLU252K, GLU255J, GLU255K, GLU262J, GLU262K, GLY159J, GLY159K, GLY199J, GLY199K, GLY215J, GLY215K, GLY245J, GLY245K, ILE172J, ILE172K, ILE204J, ILE204K, ILE208J, ILE208K, ILE246J, ILE246K, ILE247K, ILE250J, ILE250K, ILE253J, ILE253K, LEU129J, LEU129K, LEU163J, LEU163K, LEU170J, LEU170K, LEU189J, LEU189K, LEU207J, LEU207K, LEU251J, LEU251K, LYS125J, LYS125K, LYS174K, LYS259J, LYS259K, MET173J, MET173K, MET200J, MET200K, PHE128J, PHE128K, PHE158J, PHE158K, PHE167J, PHE167K, PHE203J, PHE203K, PHE205J, PHE205K, PRO131J, PRO131K, PRO171J, PRO171K, PRO190J, PRO190K, PRO206J, PRO206K, SER169J, SER169K, SER186J, SER186K, SER258J, SER258K, THR156J, THR156K, THR157J, THR157K, TRP132J, TRP132K, TYR181J, TYR260J, TYR260K, TYR261J, TYR261K, VAL164J, VAL164K, VAL165J, VAL165K, VAL187J, VAL187K, VAL212J, VAL212K, VAL214J, VAL214K, VAL256J, VAL256K
• J-L: ASN161J, ASN161L, ASN162J, ASN162L, GLY159J, GLY159L, LEU163J, LEU163L, LEU189J, LEU189L, MET200J, MET200L, PHE158J, PHE158L, THR157J, THR157L, TYR160J, TYR160L, VAL164J, VAL164L
• K-L: ALA102K, ALA102L, ALA113K, ALA113L, ALA130K, ALA130L, ALA47K, ALA47L, ARG106K, ARG106L, ARG154K, ARG154L, ARG168K, ARG168L, ARG49K, ARG49L, ARG56K, ARG56L, ASN136K, ASN136L, ASN161K, ASN161L, ASN162K, ASN162L, ASN48K, ASN48L, ASP109K, ASP109L, ASP133K, ASP133L, ASP166K, ASP166L, ASP195K, ASP195L, ASP45K, ASP45L, CYS105K, CYS105L, GLN107K, GLN107L, GLN127K, GLN127L, GLN188K, GLN188L, GLN87K, GLN87L, GLU139K, GLU139L, GLU153K, GLU153L, GLU84K, GLU84L, GLY126K, GLY126L, GLY144K, GLY144L, GLY155K, GLY155L, GLY159K, GLY159L, GLY191K, GLY191L, GLY192K, GLY192L, GLY194K, GLY194L, HIS53K, HIS53L, HIS83K, HIS83L, ILE172K, ILE172L, ILE52K, ILE52L, ILE82K, ILE82L, LEU104K, LEU104L, LEU110K, LEU110L, LEU111K, LEU111L, LEU112K, LEU112L, LEU129K, LEU129L, LEU141K, LEU141L, LEU163K, LEU163L, LEU193K, LEU193L, LYS125K, LYS125L, LYS135K, LYS135L, LYS140K, LYS140L, LYS142K, LYS142L, LYS196K, LYS196L, LYS46K, LYS46L, PHE103K, PHE103L, PHE128K, PHE128L, PHE143K, PHE143L, PHE158K, PHE158L, PHE167K, PHE167L, PRO101K, PRO101L, PRO131K, PRO131L, PRO190K, PRO190L, SER169K, SER169L, SER197K, SER197L, SER50K, SER50L, SER51K, SER51L, SER54K, SER54L, SER85K, SER85L, THR108K, THR108L, THR134L, THR156K, THR156L, THR157K, THR157L, TRP132K, TRP132L, TRP86K, TRP86L, TYR160K, TYR160L, VAL137K, VAL137L, VAL138K, VAL138L, VAL164K, VAL164L, VAL165K, VAL165L