2NPP

structure of the protein phosphatase 2a holoenzyme

• Total interactions analyzed: 28
• Total true interactions: 12
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 106
  • Norm. En. per Res.: -4.6168
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-3.1059	-38.9237	-175.483	-217.5126	100	12	1	7752	2	63	34
A-C	-88.2281	-104.6874	-298.492	-491.4075	129	21	4	12738	15	68	52
A-E	0.0	0.0	-0.0121	-0.0121	3	0	0	13	0	2	4
B-C	-66.4429	-125.3838	-284.34	-476.1666	105	21	2	11026	6	53	37
B-X	0.0	0.0	-8.2365	-8.2365	5	0	0	250	0	1	0
C-F	0.0	0.0	-0.0065	-0.0065	4	0	0	5	0	2	2
C-X	-3.7024	7.8979	-29.8021	-25.6066	23	0	0	1370	0	3	5
D-E	-8.9641	-45.2384	-166.65	-220.8525	100	19	1	7861	3	64	36
D-F	-94.4334	-110.32	-289.668	-494.4214	131	24	4	12706	15	70	51
E-F	-63.4978	-123.0224	-302.863	-489.3832	106	16	2	11285	6	56	39
E-Y	0.0	0.0	-5.6085	-5.6085	5	0	0	199	0	1	0
F-Y	-3.5182	8.4507	-31.1983	-26.2659	23	3	0	1415	0	3	5

Interface residues

• A-B: ALA184A, ALA296A, ARG105A, ARG144A, ARG182A, ARG183A, ARG200B, ARG221A, ARG258A, ARG260A, ARG319B, ARG95B, ASN195B, ASN196B, ASN209B, ASP106A, ASP139A, ASP162B, ASP176A, ASP177A, ASP215A, ASP218A, ASP24A, ASP254A, ASP61A, ASP63A, GLN151B, GLN156B, GLN193B, GLN217A, GLN26A, GLU100A, GLU101A, GLU159B, GLU204B, GLU206B, GLU216A, GLU23A, GLU295A, GLU297A, GLU62A, GLU64A, HIS207B, ILE194B, ILE197B, ILE202B, ILE235B, LEU155B, LEU158B, LEU222A, LEU223A, LEU238B, LEU66A, LEU97B, LYS152B, LYS192B, LYS239B, LYS246B, LYS248B, LYS255A, LYS281B, LYS285B, LYS323B, MET180A, PHE141A, PHE198B, PHE201B, PHE236B, PHE94B, PRO179A, PRO243B, PRO98B, PRO99B, SER100B, SER219A, SER256A, THR102A, THR142A, THR145A, THR178A, THR205B, THR96B, THR98A, TRP140A, TRP257A, TYR189B, TYR199B, TYR203B, TYR261A, TYR282B, TYR60A, VAL103A, VAL104A, VAL181A, VAL220A, VAL240B, VAL259A, VAL25A, VAL298A, VAL99A
• A-C: ALA292C, ALA457A, ALA534A, ALA68A, ARG105A, ARG106C, ARG108C, ARG110C, ARG295C, ARG302C, ARG303C, ARG418A, ARG420A, ARG459A, ARG498A, ARG49C, ARG537A, ARG70C, ASN139C, ASN383A, ASN494A, ASN535A, ASN539A, ASN79C, ASP106A, ASP11C, ASP279C, ASP280C, ASP290C, ASP453A, ASP492A, ASP531A, ASP572A, ASP574A, ASP61A, ASP63A, ASP64C, ASP77C, CYS50C, GLN26A, GLN272C, GLN288C, GLN571A, GLN580A, GLU100A, GLU101A, GLU109C, GLU277C, GLU379A, GLU3C, GLU460A, GLU581A, GLU62A, GLU64A, GLU67C, GLY138C, GLY72C, GLY73C, HIS454A, HIS497A, HIS63C, ILE111C, ILE275C, ILE458A, ILE71C, LEU278C, LEU287C, LEU29A, LEU309C, LEU382A, LEU421A, LEU496A, LEU66A, LEU67A, LEU68C, LYS283C, LYS33A, LYS416A, LYS4C, LYS542A, LYS576A, LYS74C, LYS8C, MET499A, MET66C, PHE286C, PHE289C, PHE308C, PHE503A, PHE538A, PHE578A, PHE69C, PRO291C, PRO293C, PRO305C, PRO378A, PRO493A, PRO51C, PRO532A, PRO76C, SER285C, SER75C, THR102A, THR281C, THR301C, THR304C, THR53C, THR584A, THR78C, THR7C, TRP417A, TYR107C, TYR284C, TYR307C, TYR456A, TYR495A, TYR577A, TYR80C, VAL103A, VAL104A, VAL25A, VAL455A, VAL52C, VAL533A, VAL536A, VAL573A, VAL575A, VAL65A, VAL99A
• A-E: LYS442A, LYS54E, LYS56E
• B-C: ALA106B, ALA140C, ALA333B, ARG121C, ARG135C, ARG200B, ARG268C, ARG294C, ARG302C, ARG303C, ARG89C, ASN102B, ASN139C, ASN141C, ASN264C, ASN373B, ASP109B, ASP113B, ASP131C, ASP148C, ASP306C, CYS133C, CYS266C, CYS269C, GLN122C, GLN125C, GLN331B, GLU107B, GLU111B, GLU112B, GLU114B, GLU132C, GLU188C, GLU204B, GLU206B, GLU291B, GLY105B, GLY128C, GLY138C, GLY270C, GLY90C, HIS191C, HIS245B, HIS287B, HIS329B, HIS371B, ILE123C, ILE202B, LEU134C, LEU250B, LEU279B, LEU280B, LEU309C, LYS136C, LYS144C, LYS246B, LYS248B, LYS281B, LYS285B, LYS290B, LYS374B, PHE108B, PHE201B, PHE294B, PHE308C, PHE330B, PRO103B, PRO110B, PRO115B, PRO243B, PRO284B, PRO289B, PRO305C, PRO328B, SER101B, SER120C, SER288B, SER327B, THR104B, THR124C, THR147C, THR205B, THR286B, THR301C, THR304C, THR370B, THR375B, TRP143C, TRP283B, TRP372B, TYR127C, TYR130C, TYR137C, TYR199B, TYR203B, TYR267C, TYR282B, TYR307C, TYR91C, TYR92C, VAL126C, VAL189C, VAL247B, VAL300C, VAL332B
• B-X: ASP109B, ASP113B, GLU111B, GLU112B, LEU2X
• C-F: ARG206C, ARG206F, ASP205C, ASP205F
• C-X: ALA216C, ARG214C, ARG268C, ARG4X, ARG89C, ASN117C, ASN264C, ASP202C, CYS266C, CYS269C, GLN242C, GLY215C, HIS118C, HIS241C, LEU243C, LEU2X, PRO213C, SER212C, THR219C, TRP200C, TYR127C, TYR265C, TYR267C
• D-E: ALA184D, ALA296D, ARG105D, ARG144D, ARG182D, ARG183D, ARG200E, ARG221D, ARG258D, ARG260D, ARG319E, ARG95E, ASN195E, ASN196E, ASN209E, ASP106D, ASP139D, ASP162E, ASP176D, ASP177D, ASP215D, ASP218D, ASP24D, ASP254D, ASP61D, ASP63D, GLN151E, GLN156E, GLN193E, GLN217D, GLN26D, GLU100D, GLU101D, GLU159E, GLU204E, GLU206E, GLU216D, GLU23D, GLU295D, GLU297D, GLU62D, GLU64D, HIS207E, ILE194E, ILE197E, ILE202E, ILE235E, LEU155E, LEU158E, LEU222D, LEU223D, LEU238E, LEU66D, LEU97E, LYS152E, LYS192E, LYS239E, LYS246E, LYS248E, LYS255D, LYS281E, LYS285E, LYS323E, MET180D, PHE141D, PHE198E, PHE201E, PHE236E, PHE94E, PRO179D, PRO243E, PRO98E, PRO99E, SER100E, SER219D, SER256D, THR102D, THR142D, THR145D, THR178D, THR205E, THR96E, THR98D, TRP140D, TRP257D, TYR189E, TYR199E, TYR203E, TYR261D, TYR282E, TYR60D, VAL103D, VAL104D, VAL181D, VAL220D, VAL240E, VAL259D, VAL25D, VAL298D, VAL99D
• D-F: ALA292F, ALA457D, ALA534D, ALA68D, ARG105D, ARG106F, ARG108F, ARG110F, ARG295F, ARG302F, ARG303F, ARG418D, ARG420D, ARG459D, ARG498D, ARG49F, ARG537D, ARG70F, ASN139F, ASN383D, ASN494D, ASN535D, ASN539D, ASN79F, ASP106D, ASP11F, ASP279F, ASP280F, ASP290F, ASP453D, ASP492D, ASP531D, ASP572D, ASP574D, ASP61D, ASP63D, ASP64F, ASP77F, CYS50F, GLN26D, GLN272F, GLN288F, GLN571D, GLN580D, GLU100D, GLU101D, GLU109F, GLU277F, GLU379D, GLU3F, GLU460D, GLU581D, GLU62D, GLU64D, GLU67F, GLY138F, GLY72F, GLY73F, HIS299F, HIS454D, HIS497D, HIS63F, ILE111F, ILE275F, ILE458D, ILE71F, LEU278F, LEU287F, LEU29D, LEU309F, LEU382D, LEU421D, LEU496D, LEU66D, LEU67D, LEU68F, LYS266D, LYS283F, LYS33D, LYS416D, LYS4F, LYS542D, LYS576D, LYS74F, LYS8F, MET499D, MET66F, PHE286F, PHE289F, PHE308F, PHE503D, PHE538D, PHE578D, PHE69F, PRO291F, PRO293F, PRO305F, PRO378D, PRO493D, PRO51F, PRO532D, PRO76F, SER285F, SER75F, THR102D, THR281F, THR301F, THR304F, THR53F, THR584D, THR78F, THR7F, TRP417D, TYR107F, TYR284F, TYR307F, TYR456D, TYR495D, TYR577D, TYR80F, VAL103D, VAL104D, VAL25D, VAL455D, VAL52F, VAL533D, VAL536D, VAL573D, VAL575D, VAL65D, VAL99D
• E-F: ALA106E, ALA140F, ALA333E, ARG121F, ARG135F, ARG200E, ARG268F, ARG294F, ARG302F, ARG303F, ARG89F, ASN102E, ASN139F, ASN141F, ASN264F, ASN373E, ASP109E, ASP113E, ASP131F, ASP148F, ASP306F, CYS133F, CYS266F, CYS269F, GLN122F, GLN125F, GLN331E, GLU107E, GLU111E, GLU112E, GLU114E, GLU132F, GLU188F, GLU204E, GLU206E, GLU291E, GLY105E, GLY128F, GLY138F, GLY90F, HIS191F, HIS207E, HIS245E, HIS287E, HIS329E, HIS371E, ILE123F, ILE202E, LEU134F, LEU250E, LEU279E, LEU280E, LEU309F, LYS136F, LYS144F, LYS246E, LYS248E, LYS281E, LYS285E, LYS290E, LYS374E, PHE108E, PHE201E, PHE294E, PHE308F, PHE330E, PRO103E, PRO110E, PRO115E, PRO243E, PRO284E, PRO289E, PRO305F, PRO328E, SER101E, SER120F, SER249E, SER288E, SER327E, THR104E, THR124F, THR147F, THR205E, THR286E, THR301F, THR304F, THR370E, THR375E, TRP143F, TRP283E, TRP372E, TYR127F, TYR130F, TYR137F, TYR199E, TYR203E, TYR267F, TYR282E, TYR307F, TYR91F, TYR92F, VAL126F, VAL189F, VAL247E, VAL300F, VAL332E
• E-Y: ASP109E, ASP113E, GLU111E, GLU112E, LEU2Y
• F-Y: ALA216F, ARG214F, ARG268F, ARG4Y, ARG89F, ASN117F, ASN264F, ASP202F, CYS266F, CYS269F, GLN242F, GLY215F, HIS118F, HIS241F, LEU243F, LEU2Y, PRO213F, SER212F, THR219F, TRP200F, TYR127F, TYR265F, TYR267F