2NN6

structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40

• Total interactions analyzed: 36
• Total true interactions: 21
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 132
  • Norm. En. per Res.: -4.2786
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-66.9354	-149.2248	-348.615	-564.7752	132	65	10	14519	6	52	49
A-C	0.0	0.0	-150.206	-150.206	76	31	0	9258	0	2	2
A-D	-78.0383	-29.1702	-449.296	-556.5045	193	57	5	22106	0	38	46
A-E	0.0	0.0	-0.0226	-0.0226	3	0	0	10	0	0	1
A-G	-4.2684	-29.885	-89.1171	-123.2705	75	11	2	5537	0	20	18
A-H	0.0	0.0	-0.0061	-0.0061	2	0	0	3	0	0	0
B-D	0.0	0.0	-0.0006	-0.0006	2	0	0	2	0	0	0
B-E	-19.9481	-31.9989	-173.044	-224.9909	109	19	4	8458	2	39	20
B-H	-14.4921	-8.9183	-249.055	-272.4653	132	20	6	11866	2	40	39
C-D	-15.6899	-63.9716	-286.245	-365.9065	119	71	4	13423	4	35	36
C-E	0.0	0.0	-0.0021	-0.0021	3	0	0	3	0	1	1
C-F	-31.0651	-103.3339	-258.817	-393.216	114	36	11	12440	6	28	16
C-I	0.0	0.0	-5.2227	-5.2227	17	0	0	607	0	7	1
D-G	-22.4553	-24.1255	-193.442	-240.0229	112	27	2	10013	0	34	33
D-I	0.0	0.0	-4.2953	-4.2953	13	0	0	500	0	2	9
E-F	-84.9578	-78.0093	-352.649	-515.6161	139	60	7	15325	3	34	26
E-H	-23.9367	-9.1012	-238.176	-271.214	91	72	3	10852	4	42	44
F-H	0.0	0.0	-8.0092	-8.0092	12	0	0	425	2	4	2
F-I	0.0	-6.5292	-130.69	-137.2192	73	26	8	7088	0	14	12
G-I	-3.9721	15.1583	-120.726	-109.5398	60	20	1	5583	0	37	28
H-I	0.0	5.5339	-5.0303	0.5036	8	0	0	225	0	2	1

Interface residues

• A-B: ALA108B, ALA109B, ALA178B, ALA179B, ALA185B, ALA187B, ALA196B, ALA202B, ALA217B, ALA224A, ALA254A, ARG103B, ARG104A, ARG108A, ARG111A, ARG133A, ARG153B, ARG203B, ARG211B, ARG221B, ARG229A, ARG249A, ARG63B, ARG70A, ARG93B, ARG94A, ASN103A, ASN112A, ASN226A, ASN69A, ASN79A, ASP201B, ASP207B, ASP245A, ASP92B, ASP97A, CYS109A, CYS115A, CYS232A, CYS250A, CYS96B, GLN101B, GLN104B, GLN183B, GLN194B, GLN201A, GLN235A, GLN246A, GLN95A, GLU107A, GLU107B, GLU199B, GLU206B, GLU210B, GLU214B, GLU230A, GLU84B, GLU97B, GLY180B, GLY181B, GLY193B, GLY219A, GLY238A, GLY239A, GLY255A, GLY99B, HIS188A, HIS189A, HIS205B, HIS208B, HIS228A, ILE195B, ILE223A, ILE231A, ILE234A, ILE240A, ILE253A, LEU100B, LEU102A, LEU105A, LEU184B, LEU186B, LEU188B, LEU189B, LEU197B, LEU198B, LEU204B, LEU209B, LEU213B, LEU220A, LEU221A, LEU242A, LEU243A, LEU248A, LEU68A, LEU80A, LEU98A, LEU99A, LYS101A, LYS114A, LYS244A, LYS252A, LYS67A, LYS86B, LYS94B, MET106A, MET190A, MET200B, MET225A, MET241A, MET98B, PHE198A, PHE77A, PHE78A, PRO182B, PRO191A, SER113A, SER192B, SER236A, SER237A, SER251A, SER95B, SER96A, THR105B, THR233A, TYR134B, VAL100A, VAL212B, VAL222A, VAL247A, VAL256A, VAL258A
• A-C: ALA246C, ALA255C, ARG254C, ARG258C, ARG33C, ASN38C, ASP250C, ASP267C, ASP72C, CYS251C, GLN249C, GLU261C, GLU268C, GLU31C, GLY245C, GLY30C, HIS259C, LEU248C, LEU265C, LEU29C, LEU53C, LEU63A, LYS128A, LYS247C, LYS260C, LYS263C, LYS264C, LYS276C, MET252C, MET266C, MET273C, PHE32C, SER253C, SER272C, SER65A, THR244C, THR257C, THR34C, THR35C, THR36C, THR71C, UNK421A, UNK422A, UNK423A, UNK424A, UNK425A, UNK426A, UNK427A, UNK428A, UNK429A, UNK430A, UNK431A, UNK432A, UNK433A, UNK434A, UNK435A, UNK436A, UNK437A, UNK438A, UNK439A, UNK440A, UNK441A, UNK442A, UNK443A, UNK444A, UNK445A, UNK446A, UNK447A, UNK448A, UNK449A, VAL172A, VAL256C, VAL262C, VAL269C, VAL37C, VAL64A
• A-D: ALA126D, ALA140D, ALA211D, ALA212D, ALA213D, ALA215D, ALA216D, ALA285A, ALA289A, ALA295A, ALA301A, ALA32D, ALA45D, ALA56D, ALA62D, ALA86A, ALA87A, ALA89A, ARG133A, ARG212A, ARG215A, ARG222D, ARG230D, ARG231D, ARG292A, ARG29D, ARG40D, ARG54A, ARG81D, ARG94A, ASN140A, ASN290A, ASN36D, ASN79A, ASP125D, ASP135A, ASP142A, ASP143D, ASP168D, ASP203D, ASP42A, ASP42D, ASP51D, CYS209D, CYS26D, CYS33D, CYS45A, CYS46A, CYS61A, GLN121D, GLN207D, GLN208D, GLN214D, GLN218D, GLN229D, GLN291A, GLN35D, GLN49D, GLN58A, GLN84A, GLU205D, GLU211A, GLU226D, GLU286A, GLU299A, GLU34D, GLU3A, GLU49A, GLU63D, GLU77D, GLU81A, GLU91A, GLY143A, GLY25D, GLY283A, GLY40A, GLY43D, GLY44A, GLY50D, GLY51A, GLY57A, GLY57D, GLY60D, GLY85D, GLY93A, HIS137A, HIS141A, HIS219D, HIS30D, ILE116D, ILE288A, ILE293A, ILE47A, ILE79D, ILE84D, LEU120D, LEU136A, LEU138A, LEU139A, LEU165D, LEU167D, LEU206D, LEU210D, LEU228D, LEU28D, LEU37D, LEU38D, LEU48D, LEU55D, LEU56A, LEU76D, LEU80D, LEU82A, LEU86D, LEU99A, LYS234D, LYS281A, LYS297A, LYS2A, LYS300A, LYS52A, LYS65D, LYS83D, LYS92D, MET1A, MET298A, MET85A, PHE160A, PHE223D, PHE282A, PHE284A, PHE296A, PHE31D, PHE47D, PHE77A, PHE90A, PRO302A, PRO41D, PRO61D, PRO82D, PRO87D, PRO88A, PRO92A, SER115D, SER124D, SER227D, SER233D, SER235D, SER27D, SER39D, SER44D, SER46D, SER53D, SER60A, SER83A, THR117D, THR204D, THR294A, THR41A, THR4A, THR52D, THR53A, THR75D, TYR224D, TYR232D, TYR59D, UNK412A, UNK413A, UNK414A, UNK415A, UNK416A, UNK417A, UNK418A, UNK419A, UNK420A, UNK421A, UNK422A, UNK423A, UNK424A, UNK425A, UNK426A, UNK429A, VAL118D, VAL119D, VAL122D, VAL123D, VAL134A, VAL220D, VAL54D, VAL58D, VAL59A, VAL64D, VAL78D
• A-E: ARG94A, ARG96E, SER96A
• A-G: ALA17A, ALA240G, ALA250G, ARG107G, ARG11A, ARG12A, ARG16A, ARG212A, ARG235G, ARG23A, ASN140A, ASN251G, ASN8A, ASP131G, ASP160G, ASP195G, ASP25A, CYS9A, GLN157G, GLN194G, GLN244G, GLN245G, GLU10A, GLU136G, GLU19A, GLU20A, GLU254G, GLU3A, GLY118G, GLY133G, GLY134G, GLY159G, GLY193G, GLY196G, GLY26A, HIS258G, ILE117G, ILE119G, ILE162G, ILE18A, ILE192G, ILE243G, ILE293A, LEU14A, LEU15A, LEU161G, LEU197G, LEU198G, LEU247G, LEU24A, LEU6A, LYS106G, LYS200G, LYS21A, LYS22A, LYS239G, LYS241G, LYS2A, LYS52A, PHE13A, PHE199G, PRO137G, PRO5A, SER135G, SER7A, THR121G, THR242G, THR246G, THR4A, TRP237G, TYR108G, VAL120G, VAL132G, VAL158G, VAL238G
• A-H: GLU49H, MET241A
• B-D: ARG93B, LEU86D
• B-E: ALA129B, ALA32B, ALA34B, ALA49B, ALA49E, ALA78B, ALA87E, ALA89E, ARG27B, ARG50E, ARG58B, ARG63B, ARG85B, ARG87B, ARG88B, ARG96E, ASN44B, ASN44E, ASN72B, ASP121B, ASP130B, ASP138E, ASP35B, ASP57E, ASP84E, ASP92B, ASP99E, CYS144E, CYS73B, CYS85E, GLN119B, GLN125B, GLN128B, GLN217E, GLN33B, GLN74B, GLU143E, GLU38E, GLU41B, GLU65E, GLU80E, GLU84B, GLU92E, GLU94E, GLY145E, GLY36B, GLY47E, GLY54E, GLY59B, GLY61E, GLY83B, GLY95E, GLY98E, HIS55B, HIS55E, HIS90B, ILE122B, LEU127B, LEU135E, LEU140E, LEU141E, LEU142E, LEU216E, LEU48B, LEU59E, LYS46B, LYS52E, LYS63E, LYS86B, PHE31B, PHE80B, PHE81E, PHE82E, PHE93E, PRO89B, PRO91E, SER37B, SER43E, SER46E, SER48E, SER76B, SER77B, SER81B, SER86E, SER88E, THR45E, THR56E, THR5E, THR79B, THR82B, THR90E, TYR123B, TYR136E, TYR39B, TYR52B, TYR75B, VAL124B, VAL126B, VAL134E, VAL137E, VAL139E, VAL30B, VAL41E, VAL42E, VAL50B, VAL51B, VAL60E, VAL62E, VAL83E
• B-H: ALA109B, ALA144B, ALA148B, ALA153H, ALA191B, ALA238B, ALA32B, ALA34B, ALA54H, ALA57H, ALA69B, ALA71H, ARG103H, ARG117B, ARG153B, ARG229B, ARG232B, ARG236B, ARG238H, ARG248H, ARG285H, ARG41H, ARG58B, ARG61B, ARG75H, ARG87H, ARG95H, ASN101H, ASP105H, ASP121B, ASP147B, ASP151H, ASP154B, ASP228B, ASP31H, ASP35B, GLN119B, GLN173H, GLN194B, GLN233B, GLN247H, GLN33B, GLN92H, GLU237B, GLU49H, GLU56B, GLU61H, GLU90H, GLU99H, GLY149B, GLY152H, GLY29B, GLY30H, GLY36B, GLY44H, GLY48H, GLY53B, GLY58H, HIS115B, HIS224B, HIS234B, HIS25H, HIS43H, HIS55B, ILE110B, ILE120B, ILE150B, ILE240B, ILE53H, ILE57B, ILE77H, ILE88H, LEU104H, LEU111B, LEU114B, LEU143B, LEU146B, LEU189B, LEU227B, LEU26H, LEU72H, LYS273H, LYS70H, LYS73H, LYS97H, MET152B, MET249H, MET250H, MET28B, PHE155B, PHE31B, PRO116B, PRO151B, PRO176H, PRO190B, PRO29H, PRO54B, SER102H, SER106H, SER118B, SER150H, SER175H, SER192B, SER239B, SER37B, SER55H, SER59H, THR100H, THR142B, THR225B, THR246H, THR32H, THR45H, THR74H, THR89H, TYR46H, TYR52B, TYR76H, VAL107H, VAL145B, VAL156B, VAL230B, VAL231B, VAL235B, VAL27H, VAL28H, VAL30B, VAL51B, VAL56H, VAL60H, VAL69H, VAL98H
• C-D: ALA102C, ALA104D, ALA105C, ALA110C, ALA179D, ALA184D, ALA211D, ALA246C, ALA90D, ARG149D, ARG178D, ARG190D, ARG94C, ARG94D, ARG96D, ARG99D, ASN100D, ASN115C, ASN72D, ASP111C, ASP186D, ASP202C, ASP203C, ASP203D, ASP227C, CYS102D, CYS233C, CYS234C, CYS251C, GLN103C, GLN107C, GLN117C, GLN207D, GLN214D, GLN249C, GLU100C, GLU101C, GLU103D, GLU114C, GLU189D, GLU205D, GLU229C, GLU77D, GLU91D, GLU95D, GLY199D, GLY220C, GLY230C, GLY239C, GLY240C, GLY242C, GLY245C, GLY88D, GLY99C, HIS236C, ILE148C, ILE224C, ILE98D, LEU149C, LEU181D, LEU185D, LEU192D, LEU193D, LEU200D, LEU205C, LEU206D, LEU210D, LEU222C, LEU232C, LEU235C, LEU243C, LEU248C, LEU97D, LYS191D, LYS198D, LYS231C, LYS237C, LYS247C, LYS73D, LYS92D, MET194D, MET226C, MET252C, PHE108C, PHE183D, PHE201C, PHE93C, PRO238C, PRO98C, SER106C, SER116C, SER195D, SER196D, SER202D, SER241C, SER253C, SER93D, THR101D, THR182D, THR191C, THR197D, THR204C, THR204D, THR219C, THR221C, THR223C, THR244C, TYR144C, TYR201D, VAL104C, VAL105D, VAL112C, VAL180D, VAL200C, VAL225C, VAL256C, VAL78D, VAL89D, VAL8C
• C-E: GLU65C, LEU71E, PHE66C
• C-F: ALA103F, ALA106F, ALA112F, ALA148F, ALA45C, ALA49F, ALA53F, ALA64C, ALA65F, ALA67C, ARG101F, ARG102F, ARG108F, ARG109F, ARG110F, ARG111F, ARG201F, ARG33C, ARG42F, ARG70F, ARG92C, ARG94C, ASN55C, ASN82C, ASP138C, ASP143C, ASP145C, ASP153F, ASP46C, ASP84C, ASP99F, CYS137C, CYS141C, CYS60C, CYS64F, CYS89C, GLN143F, GLN48F, GLU145F, GLU152F, GLU213C, GLU65C, GLY107F, GLY146C, GLY154F, GLY155F, GLY212C, GLY44F, GLY47C, GLY51F, GLY54C, GLY58F, GLY59F, GLY61C, GLY68F, GLY96C, ILE140C, ILE42C, ILE59C, LEU135C, LEU139C, LEU142C, LEU149F, LEU150F, LEU151F, LEU165C, LEU45F, LEU46F, LEU50C, LEU63F, LEU85C, LEU88C, LEU97F, LYS50F, LYS52C, LYS61F, LYS63C, PHE105F, PHE66C, PHE93C, PRO104F, PRO113F, PRO114F, PRO81C, PRO86C, PRO87C, PRO97C, PRO98C, SER147F, SER41C, SER43C, SER47F, SER48C, SER52F, SER67F, SER90C, SER91C, SER95C, THR44C, THR56C, THR57C, THR60F, TRP133C, TYR136C, TYR144C, TYR54F, VAL134C, VAL146F, VAL58C, VAL62C, VAL62F, VAL66F, VAL80C, VAL83C
• C-I: ARG100I, ASN97I, GLN163I, GLU12C, GLU9C, GLY101I, HIS86I, ILE127I, LEU88I, LEU95I, LYS74I, LYS96I, PRO10C, THR7C, TYR89I, VAL155I, VAL8C
• D-G: ALA144D, ALA150D, ALA16G, ALA47G, ALA62D, ARG107G, ARG113D, ARG149D, ARG207G, ARG222D, ARG225D, ARG230D, ARG231D, ARG40D, ARG84G, ARG86G, ASN170G, ASN36D, ASP102G, ASP143D, ASP172G, ASP42D, CYS138D, CYS82G, GLN104G, GLN105G, GLN229D, GLN25G, GLN35D, GLU136G, GLU174G, GLU189D, GLU226D, GLU257G, GLU31G, GLU32G, GLU42G, GLU63D, GLY108D, GLY133G, GLY134G, GLY145D, GLY204G, GLY30G, GLY43D, GLY45G, GLY46G, GLY60D, GLY83G, HIS111D, HIS258G, ILE116D, LEU107D, LEU110D, LEU141D, LEU151D, LEU203G, LEU228D, LEU23G, LEU28G, LEU37D, LEU38D, LEU78G, LYS106G, LYS129G, LYS171G, LYS200G, LYS208G, LYS234D, LYS65D, LYS81G, MET139D, MET148D, MET173G, PHE152D, PHE221D, PRO112D, PRO137G, PRO147D, PRO175G, PRO29G, PRO41D, PRO44G, PRO61D, SER103G, SER115D, SER135G, SER187D, SER227D, SER233D, SER235D, SER39D, SER44D, THR114D, THR121G, THR202G, THR80G, TYR108G, TYR224D, TYR232D, TYR59D, VAL101G, VAL105D, VAL109G, VAL142D, VAL146D, VAL188D, VAL26G, VAL27G, VAL58D, VAL64D, VAL79G
• D-I: ARG100I, ARG113D, ASN72D, ASN79I, GLY125I, HIS111D, HIS86I, ILE78I, LYS84I, PRO112D, PRO124I, SER76I, SER77I
• E-F: ALA106E, ALA123F, ALA125F, ALA129F, ALA133F, ALA207F, ALA208F, ALA209F, ALA214F, ALA223F, ALA224E, ALA238F, ALA240F, ARG102F, ARG109F, ARG111E, ARG120F, ARG240E, ARG242F, ARG261E, ARG93F, ARG95F, ARG96E, ASN107E, ASN114E, ASN115E, ASN220F, ASP100E, ASP178F, ASP248E, ASP99E, CYS117F, CYS238E, CYS248F, GLN127F, GLN221F, GLN249F, GLU104E, GLU118F, GLU119F, GLU121F, GLU128F, GLU131F, GLU204F, GLU205F, GLU230F, GLU235F, GLU239F, GLU250E, GLU254E, GLU257E, GLU72E, GLU8E, GLY102E, GLY116F, GLY210F, GLY224F, GLY227F, GLY229F, GLY231F, GLY232F, GLY234E, GLY243E, GLY244F, GLY245E, GLY259E, GLY97E, GLY98E, ILE105E, ILE112E, ILE252E, LEU101E, LEU122F, LEU124F, LEU126F, LEU130F, LEU136F, LEU158F, LEU162F, LEU211F, LEU215F, LEU219F, LEU223E, LEU225F, LEU226E, LEU226F, LEU227E, LEU233F, LEU243F, LEU245F, LEU247E, LEU6E, LEU71E, LEU92F, LEU96F, LYS116E, LYS233E, LYS241E, LYS244E, LYS260E, LYS73E, MET216F, MET239E, MET255E, MET256E, PHE113E, PHE253E, PHE93E, PRO132F, PRO198E, PRO249E, SER117E, SER118E, SER225E, SER228F, SER229E, SER236F, SER246E, SER251E, THR103E, THR108E, THR212F, THR231E, THR234F, THR237E, THR258E, TRP237F, TYR110E, VAL134F, VAL180F, VAL213F, VAL222F, VAL228E, VAL230E, VAL235E, VAL236E, VAL241F, VAL242E, VAL262E
• E-H: ALA220E, ALA229H, ALA9E, ARG231H, ARG236H, ARG238H, ARG23E, ARG27E, ARG33E, ARG87H, ASN222H, ASN239H, ASP139H, ASP21E, ASP230H, ASP25E, ASP270H, ASP31E, CYS240H, CYS34E, GLN136H, GLN168H, GLN173H, GLN19E, GLN217E, GLN267H, GLU10E, GLU137H, GLU20E, GLU218E, GLU224H, GLU232H, GLU275H, GLU36E, GLU8E, GLU99H, GLY138H, GLY167H, GLY169H, GLY17E, GLY26E, GLY28E, GLY54E, GLY86H, HIS16E, HIS55E, ILE141H, ILE14E, ILE234H, ILE242H, ILE268H, ILE271H, ILE88H, LEU135H, LEU140H, LEU166H, LEU171H, LEU216E, LEU223H, LEU228H, LEU22E, LEU237H, LEU272H, LEU6E, LYS11E, LYS165H, LYS269H, LYS273H, LYS52E, PHE202H, PHE219H, PRO207H, PRO225H, PRO274H, SER227H, SER235H, SER7E, THR215E, THR5E, THR89H, TRP204H, TYR13E, TYR32E, VAL12E, VAL15E, VAL170H, VAL18E, VAL226H, VAL233H, VAL24E, VAL35E
• F-H: ARG132H, ARG141F, ARG93F, GLN136H, GLN92H, GLN93H, GLU137H, GLU90H, GLY138H, LEU129H, LEU92F, VAL91H
• F-I: ALA133F, ALA166F, ALA170F, ALA172F, ALA262F, ALA263F, ALA268F, ALA269F, ALA270F, ALA38I, ARG135F, ARG138F, ARG13I, ARG261F, ARG264F, ARG265F, ARG266F, ARG29I, ARG57I, ARG6I, ASP171F, ASP178F, CYS40I, CYS8I, GLN221F, GLN256F, GLN257F, GLN71F, GLU12I, GLU175F, GLU58I, GLY11I, GLY173F, GLY23I, GLY25I, GLY267F, GLY39I, HIS30I, ILE9I, LEU167F, LEU169F, LEU179F, LEU219F, LEU255F, LEU259F, LEU37I, LEU41I, MET176F, MET216F, PHE34I, PRO10I, PRO132F, PRO217F, PRO253F, SER140I, SER24I, SER258F, SER35I, SER36I, THR26I, THR28I, TYR139F, TYR177F, TYR252F, TYR27I, TYR7I, VAL134F, VAL174F, VAL180F, VAL218F, VAL260F, VAL55I, VAL56I
• G-I: ALA169G, ALA41G, ALA47G, ARG123I, ARG185G, ARG50G, ARG76G, ARG81I, ASN170G, ASN79I, ASP126G, ASP172G, ASP40G, ASP75G, CYS174I, GLN173I, GLN38G, GLU117I, GLU159I, GLU174G, GLU176G, GLU37G, GLU39G, GLU42G, GLU49G, GLY125G, GLY125I, GLY161I, GLY74G, HIS178I, ILE118I, ILE127G, ILE162I, ILE78I, LEU143G, LEU77G, LYS120I, LYS129G, LYS171G, LYS176I, LYS180I, MET173G, PHE82I, PRO124I, PRO175G, PRO175I, SER124G, SER139G, SER141G, SER158I, SER160I, SER76I, SER77I, SER80I, THR177I, THR179I, TYR119I, VAL167G, VAL168G, VAL48G
• H-I: ALA138I, ARG132H, ASP137I, GLN139I, GLN93H, GLU128H, GLY136I, LYS94H